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Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways 认领 引用
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作者 Siva Sundara Kumar Durairajan Abhay Kumar Singh +6 位作者 Shahitha M Sulaiman Supriti Patnaik Senthilkumar Krishnamoorthi Ashok Iyaswamy Balachandar Vellingiri Chuan-Bin Yang Leonard L Williams 《World Journal of Gastroenterology》 SCIE CAS 2025年第48期26-49,共24页
Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD),has been increasingly associated with the progression of neurodegenerative disorders,particularly Alzheimer’s disease(AD).Emerg... Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD),has been increasingly associated with the progression of neurodegenerative disorders,particularly Alzheimer’s disease(AD).Emerging data from population-based meta-analyses and in vivo experimental models demonstrate that systemic inflammation associated with IBD exacerbates disruption of the gut-brain axis(GBA).This disruption promotes the deposition of amyloid-β(Aβ)plaques,and cognitive decline.Together,these effects contribute to the progression of AD.Chronic colitis,a hallmark of IBD,accelerates Aβpathology and induces cognitive impairment in transgenic mouse models,providing direct evidence of the detrimental effects of gut inflammation on neurodegeneration.Although numerous clinical and meta-analytical studies have examined the prevalence of AD in IBD patients,the molecular mechanisms underlying this association remain inadequately understood.In particular,the roles of immune regulation and GBA interactions require further investigation.This review aims to critically compile current evidence that elucidates the shared pathophysiological mechanisms underlying this association,such as chronic systemic inflammation,gut dysbiosis,and dysregulated immune responses.Although anti-inflammatory therapies,probiotics,and modulation of the gut microbiota have the potential to reduce the risk of AD and slow its progression,age-related gut inflammation and dysbiosis can aggravate AD pathology.This underscores the necessity for treatments that specifically target IBD-associated inflammation to limit AD progression.In addition,this review also meticulously examines how immune signaling and regulatory pathways in IBD,such as triggering receptor expression via myeloid cell receptor activation;NLRP3 inflammasome-driven inflammation;disrupted interleukin(IL)-1β,IL-6,and tumor necrosis factor-alpha(TNF-α)signaling;and elevated C-reactive protein levels,contribute to increased amyloidogenesis.This paper proposes a comprehensive framework for therapeutic strategies targeting IBD-related inflammation and elucidates their potential to attenuate the progression of AD. 展开更多
关键词 Inflammatory bowel disease Alzheimer’s disease Amyloidogenesis Inflammatory pathways Immune signaling Gut-brain axis Therapeutics
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Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies 认领 引用 被引量：9
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作者 Abhay Kumar Singh Siva Sundara Kumar Durairajan +1 位作者 Ashok Iyaswamy Leonard L Williams 《World Journal of Gastroenterology》 SCIE CAS 2024年第40期4404-4410,共7页
Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly ... Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people.This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder.Some studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis.Therefore,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory responses.We examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways involved.Additionally,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and prebiotics.We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis. 展开更多
关键词 Gut microbiota Dysbiosis Gout Hyperuricemia Inflammation Intestinal barrier Probiotics Prebiotics Fecal microbiota transplantation
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Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease 认领 引用 被引量：1
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作者 Supriti Patnaik Siva Sundara Kumar Durairajan +5 位作者 Abhay Kumar Singh Senthilkumar Krishnamoorthi Ashok Iyaswamy Shiva Prasad Mandavi Rajesh Jeewon Leonard L Williams 《World Journal of Gastroenterology》 SCIE CAS 2024年第48期5212-5220,共9页
The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease(IBD).While research has focused on the bacterial microbiome,recent studies have shifted towards host genetics ... The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease(IBD).While research has focused on the bacterial microbiome,recent studies have shifted towards host genetics and host-fungal interactions.The mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune regulation.Among fungi,Candida species,particularly Candida albicans(C.albicans),have been extensively studied due to their dual role as gut commensals and invasive pathogens.Recent findings indicate that various strains of C.albicans exhibit consid-erable differences in virulence factors,impacting IBD's pathophysiology.Intestinal fungal dysbiosis and antifungal mucosal immunity may be associated to IBD,especially Crohn's disease(CD).This article discusses intestinal fungal dysbiosis and antifungal immunity in healthy individuals and CD patients.It discusses factors influencing the mycobiome's role in IBD pathogenesis and highlights significant contributions from the scientific community aimed at enhancing understanding of the mycobiome and encouraging further research and targeted intervention studies on specific fungal populations.Our article also provided insights into a recent study by Wu et al in the World Journal of Gastroenterology regarding the role of the gut microbiota in the pathogenesis of CD. 展开更多
关键词 Inflammatory bowel disease Ulcerative colitis Crohn's disease Gut mycobiome dysbiosis Candida species Immune regulation Gut inflammation Fecal mycobiota transplantation
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Signature of the 27-day variation in hemispheric sunspot activity and asymmetry during 2010-2015 认领 引用
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作者 Prithvi Raj Singh Ahmad Islam Saad Farid +1 位作者 Tarun Kumar Pant Abhay Kumar Singh 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第4期331-340,共10页
In the present work,we study the time evolution,significance of the N-S asymmetry excesses presented as a function of the solar cycle and prominent rotational periods(~27 d)separately for the northern and southern hem... In the present work,we study the time evolution,significance of the N-S asymmetry excesses presented as a function of the solar cycle and prominent rotational periods(~27 d)separately for the northern and southern hemispheres.We have investigated short-term variations of the hemispheric solar activity(sunspot numbers and sunspot areas)during the time period 2010-2015,which covers the ascending and the maximum phase of solar cycle 24.We have implemented the Lomb-Scargle periodogram and continuous wavelet transform power spectrum techniques to study the time evolution and dominant rotational periods separately for the northern and southern hemispheres,and whole solar disk.Our results showed that the northern hemisphere exhibited longer solar synodic periods than the southern hemisphere,indicating that the northern hemisphere has a lower rotation rate.Moreover,the northern hemisphere was found to be dominant before transferring to the southern hemisphere during mid-2013.Also,the sunspot areas clearly demonstrated a two-peak structure of solar activity in the northern and southern hemispheres respectively during 2012 and 2014.The statistical significance of the southern hemisphere affirmed enhanced excess during the maximum phase of solar cycle 24. 展开更多
关键词 Sunspots Sunspot Area Asymmetry Solar Cycle
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Peroxisome proliferator-activated receptor agonists:A new hope towards the management of alcoholic liver disease 认领 引用
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作者 Siva Sundara Kumar Durairajan Abhay Kumar Singh Ashok Iyaswamy 《World Journal of Gastroenterology》 SCIE CAS 2024年第35期3965-3971,共7页
In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the inte... In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of ALD.The study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by ALD.Effective therapies are necessary for ALD because it is a critical health issue that affects people worldwide.This editorial analyzes the possibility of PPAR agonists as treatments for ALD.As key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of ALD.We assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver diseases.Recent research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver disease.This editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for ALD.Further research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD. 展开更多
关键词 Alcoholic liver disease Peroxisome proliferator-activated receptors Peroxisome proliferator-activated receptors agonists Liver fibrosis Inflammation Metabolic regulation Hepatoprotection
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Amorphous and nanophase microstructures of bulk Se-based chalcogenide alloys 认领 引用
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作者 Abhay Kumar Singh 《Optoelectronics Letters》 EI 2012年第3期165-167,共3页
The composition-dependent microstructural morphology variations of Se89Zn2Te5In4 and Se87Zn2Te5In6 chalcogenide alloys are investigated. Glassy and nanophase surfaces and structural morphologies of these alloys have b... The composition-dependent microstructural morphology variations of Se89Zn2Te5In4 and Se87Zn2Te5In6 chalcogenide alloys are investigated. Glassy and nanophase surfaces and structural morphologies of these alloys have been described with help of scanning electron microscope (SEM) and transmission electron microscope (TEM), and their elemental concentrations are confirmed from the energy dispersive X-ray spectroscopy (EDX). Experimental results demonstrate that the microstructure of Se89Zn2Te5In4 alloy belongs to pure glassy state, while the Se87Zn2Te5In6 alloy is with nanophase structure. 展开更多
关键词 纳米结构 微观结构 合金 硫系 透射电子显微镜 扫描电子显微镜 非晶 散装
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Enhancement of Phase Matching Ability in One-Dimensional Photonic Crystal through Plasma Materials 认领 引用
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作者 Surendra Prasad Vivek Singh Abhay Kumar Singh 《Journal of Electromagnetic Analysis and Applications》 2011年第7期255-260,共6页
We have theoretically studied the modal dispersion equation and effective refractive index of one-dimensional plasma photonic crystals (1-D PPCs) having different materials in one unit cell. The dispersion relations r... We have theoretically studied the modal dispersion equation and effective refractive index of one-dimensional plasma photonic crystals (1-D PPCs) having different materials in one unit cell. The dispersion relations related for such structure is derived by solving Maxwell’s equation using the transfer matrix method. It is found that the presence of plasma in a unit cell enhanced the phase matching ability and provides additional degree of freedom to control phase matching condition compared to the conventional one-dimensional photonic crystals (1-D PCs). 展开更多
关键词 One Dimensional Photonic Crystal Plasma Photonic Crystal Transfer Matrix Method Dispersion Relation Phase Matching
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DNA cyclic codes over the ring F2[u, v]/ (u^2 - 1, v^3 - v, uv - vu) 认领 引用
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作者 Hai Q. Dinh Abhay Kumar Singh +1 位作者 Sukhamoy Pattanayak Songsak Sriboonchitta 《International Journal of Biomathematics》 SCIE 2018年第3期247-265,共19页
In this paper, our main objective is to find out the necessary and sufficient conditions for a cyclic code of arbitrary length over the ring of four elements R1 = F2 ＋ u2 （u^2 = 1） to be a reversible cyclic code. W... In this paper, our main objective is to find out the necessary and sufficient conditions for a cyclic code of arbitrary length over the ring of four elements R1 = F2 ＋ u2 （u^2 = 1） to be a reversible cyclic code. We also obtain the structure of cyclic DNA codes of odd length over the ring R = F2 [u, v]/（u^2 -1, v^3 -v, uv- vu）, which plays an important role in Computational Biology. Furthermore, we establish a direct link between the elements of ring /{ and 64 codons used in the amino acids of living organisms by introducing a Gray map from R to R1. Among others, binary images of cyclic codes over R are also investigated. As applications, some cyclic DNA codes over R using the Gray map are provided. 展开更多
关键词 Cyclic DNA codes reversible cyclic codes reversible-complement cyclic codes gray map.
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DNA computing over the ring Z4[v]/(v^2-v) 认领 引用
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作者 Narendra Kumar Abhay Kumar Singh 《International Journal of Biomathematics》 SCIE 2018年第7期149-166,共18页
In this paper,we discuss the DNA construction of general length over the finite ring =Z4+vZ4,with v2=v,which plays a very significant role in DNA computing.We discuss the GC weight of DNA codes over R.Several examples... In this paper,we discuss the DNA construction of general length over the finite ring =Z4+vZ4,with v2=v,which plays a very significant role in DNA computing.We discuss the GC weight of DNA codes over R.Several examples of reversible cyclic codes over R are provided,whose Z4-images are Z4-1inear codes with good parameters. 展开更多
关键词 Cyclic codes DNA codes GC weight
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