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Electrospray self-healing porous polymer microspheres for multimode imaging and combined photothermal/chemodynamic therapy of nasopharyngeal carcinoma 认领 引用
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作者 Yifan Huang Aiyu Li +7 位作者 Meijuan He Huxiao Sun Zhuo Li Jiahui Liu Jiansong Xing Han Wang Mingwu Shen Xiangyang Shi 《Science China Materials》 SCIE EI CAS CSCD 2026年第8期5157-5170,共14页
Minimally invasive yet effective treatment of nasopharyngeal carcinoma(NPC)is a major challenge,particularly because of the anatomical complexity of the nasopharynx and the limitations of conventional therapies in ach... Minimally invasive yet effective treatment of nasopharyngeal carcinoma(NPC)is a major challenge,particularly because of the anatomical complexity of the nasopharynx and the limitations of conventional therapies in achieving precise targeting and sufficient therapeutic efficacy.Here,we present a multifunctional platform derived from heat-triggered electrospray self-healing porous poly(lactic-coglycolic acid)(PLGA)microspheres encapsulated with indocyanine green(ICG),sequentially coated with tannic acidFe3+(TAF)metal-phenolic network and fibronectin(FN)for targeted photothermal/chemodynamic combined therapy of NPC.The prepared functional microspheres(PI-TAF@FN)with an average size of 1.9μm demonstrate excellent colloidal stability,heat-induced self-healing performance,and high photothermal conversion efficiency(51.4%).These microspheres can target NPC cells through FN-mediated integrin recognition and can exert ICG/TAF-mediated photothermal therapy under an 808-nm laser irradiation and TAF-mediated chemodynamic therapy for enhanced cancer cell apoptosis induction in vitro.The functional PI-TAF@FN microspheremediated combined photothermo-chemodynamic therapy enables effective treatment of a mouse NPC model with minimal systemic toxicity.Furthermore,the PI-TAF@FN microspheres with dual components of TAF and ICG enable multi-mode FN-targeted T1-weighted magnetic resonance/fluorescencehermal imaging of tumors for precision NPC treatment.The developed electrospray self-healing porous microspheres may be developed as a unique theranostic platform that can integrate different therapeutic and diagnostic components for precision theranostics of different types of tumors.Author contributions Huang Y,Li A,He M,Sun H,Li Z,Liu J and Xing J contributed to methodology,investigation,and data curation.Huang Y and Li A were additionally responsible for validation and formal analysis,and Huang Y drafted the original manuscript.Wang H provided resources and funding acquisition.Shen M and Shi X supervised the work,contributed to conceptualization,resources,funding acquisition,and project administration,with Shi X also responsible for writing,reviewing,and editing. 展开更多
关键词 self-healing microspheres metal-phenolic network fibronectin nasopharyngeal carcinoma photothermal therapy chemodynamic therapy
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Formation Energies of the Lithium Intercalations in MoS_2 认领 引用
2
作者 Aiyu LI Huiying LIU +2 位作者 Zizhong ZHU Meichun HUANG Yong YANG 《Journal of Materials Science & Technology》 SCIE EI CAS 2006年第1期40-44,共5页
First-principles calculations have been performed to study the lithium intercalations in MoS2. The formation energies, changes of volumes, electronic structures and charge densities of the lithium intercalations in Mo... First-principles calculations have been performed to study the lithium intercalations in MoS2. The formation energies, changes of volumes, electronic structures and charge densities of the lithium intercalations in MoS2 are presented. Our calculations show that during lithium intercalations in MoS2, the lithium intercalation formation energies per lithium atom are between 2.5 eV to 3.0 eV. The volume expansions of MoS2 due to lithium intercalations are relatively small 展开更多
关键词 Formation energies MoS2 Li intercalation ab initio calculation
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Smart dendrimer nanogels boost mRNA-based cancer therapy via synergistic glycolysis inhibition and immune activation 认领 引用
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作者 Xianghao Xiao Yue Gao +7 位作者 Aiyu Li Yiyang Jia Jingjing Li Mengjiao Zhang Ruiqi Ji Mingwu Shen Andrij Pich Xiangyang Shi 《Bioactive Materials》 SCIE CSCD 2026年第2期3-14,共12页
Cancer mRNA vaccine has emerged as a promising immunotherapy approach.However,development of functional vehicles for safe and efficient mRNA delivery into immune cells(e.g.,dendritic cells,DCs)remains to be challengin... Cancer mRNA vaccine has emerged as a promising immunotherapy approach.However,development of functional vehicles for safe and efficient mRNA delivery into immune cells(e.g.,dendritic cells,DCs)remains to be challenging,and most of the mRNA-based vaccines just act on immune cells for improved anticancer immunity without additional input to tackle cancer cells,ultimately limiting the anticancer efficacy.Herein,we report the development of pH-responsive dual-action dendrimer nanogels(DNGs)to deliver gp100 mRNA as a potential nanovaccine.Mannose-conjugated generation 3 poly(amidoamine)dendrimers were crosslinked through dual functional polyethylene glycol with both ends of aldehyde groups to form pH-responsive DNGs.The DNGs with a size of 45.7 nm show excellent colloidal stability and cytocompatibility and allow dual-actions for DC-targeted mRNA delivery and cancer cell glycolysis inhibition.In a subcutaneous mouse melanoma model,the DNG/mRNA vaccine exerted glycolytic inhibition effect and triggered robust antitumor immune responses to suppress the tumor growth,especially in combination with anti-PD-L1 antibody-mediated immune checkpoint blockade.Meanwhile,the local vaccination of the vaccine enabled effective tumor occurrence prevention.Such a DNGbased mRNA vaccine with dual actions on both DCs and cancer cells may be applied for improved immunotherapy of other cancer types. 展开更多
关键词 Dendrimers Nanogels Cancer immunotherapy mRNA vaccine Mannose Glycolysis inhibition
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