期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到1,009篇文章
< 1 2 … 51 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Construction of through-space charge transfer donor-acceptor coordination polymers through the combination of planar electron-deficient/rich ligands 认领 引用
1
作者 Zhen-Wei Zhang Da-Shuai Zhang +10 位作者 Wei Wang Xiao-Ting Liu Hui Hu Yong-Zheng Zhang Longlong Geng Bin Li Yuchen Deng Rongmin Wei Xiuling Zhang Yuexing Zhang Ze Chang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期762-766,共5页
In this paper,a new series of donor-acceptor coordination polymers(DACPs),[Cd(dppz)(R-ndc)(H2O)]n(R=none,DZU-400;R=F,DZU-400-F;R=Br,DZU-400-Br;DZU is short for Dezhou University),[Cd(dppz)(adc)(H2O)]n(DZU-... In this paper,a new series of donor-acceptor coordination polymers(DACPs),[Cd(dppz)(R-ndc)(H2O)]n(R=none,DZU-400;R=F,DZU-400-F;R=Br,DZU-400-Br;DZU is short for Dezhou University),[Cd(dppz)(adc)(H2O)]n(DZU-401),and{[Cd(dppz)(adb)0.5(HCOO)(H2O)]}n(DZU-402),have been successfully constructed through the combination of electron-deficient dipyrido[3,2-a:2',3'-c]phenazine(dppz)as an acceptor and various dicarboxylic ligands(H2ndc=2,3-naphthalenedicarboxylic acid,F-H2ndc=6,7-difluorona phthalene-2,3-dicarboxylic acid,Br-H2ndc=6,7-dibromonaphthalene-2,3-dicarboxylic acid,H2adc=9,10-anthracenedicarboxylic acid,and H2adb=4,4'-(anthracene-9,10-diyl)dibenzoic acid)with electron-rich planar aromatic rings as donors.Structural analyses reveal closely parallel arrangement of the planar acceptor and donor units in these DACPs,which could facilitate the through-space charge transfer(TSCT)interactions of the D-A systems and the corresponding luminescent properties.Interestingly,the DACPs show highly regulable donor dependent photoluminescence from blue to orange.Based on the TSCT based luminescence and the high thermal stability of the DACPs,their thermal-stimuli responsive emission properties were further studied.Photoluminescence intensity of the DACPs all present good linearity with temperature(298-473K),as proved by variable temperature fluorescence spectra.Importantly,the temperature sensing process is reversible and recyclable,suggesting the promising applications of the DACPs as thermal-stimuli responsive materials. 展开更多
关键词 Donor-acceptor Coordination polymers Through-space charge transfer Tunable luminescence Temperature sensing
暂未订购 下载PDF
Coupled FEM-DEM modeling of permeability evolution in rough fractured shale during shearing under varying confining pressures 认领 引用 被引量：2
2
作者 Bin Li Qi Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第3期1736-1754,共19页
The dynamic evolution of fracture permeability presents a critical scientific challenge in rock masses.Understanding the mechanisms of rock mass permeability evolution is vital for engineering project design and opera... The dynamic evolution of fracture permeability presents a critical scientific challenge in rock masses.Understanding the mechanisms of rock mass permeability evolution is vital for engineering project design and operations.By integrating the discrete element method(DEM)with the finite element method(FEM),a numerical simulation framework for shear seepage in rough fractured shale has been developed to investigate the dynamic mechanisms of permeability evolution under varying confining pressures and during the shearing process.Numerical simulations were conducted on rough fractured samples under effective confining pressures ranging from 5 MPa to 20 MPa to monitor the aperture and permeability evolution of the fracture.The results of the numerical simulation are consistent with the experimental observations,indicating that both the shearing process and confining pressure significantly influence permeability.Moreover,the magnitude of the confining pressure is a crucial factor influencing the trend in permeability changes.Under a confining pressure of 5 MPa,fracture permeability initially increases significantly but decreases post-shearing.In contrast,a continuous decrease in fracture permeability is observed when the confining pressure exceeds 10 MPa.The results of the shear numerical simulation indicate that the confining pressure restricts fracture dilation during shearing,promotes the generation of rock debris,and decreases both the permeability and transmissivity of the fracture.The wear results obtained from numerical simulations are consistent with the experimental patterns and correlate with the joint roughness coefficient(JRC).This study proposed an effective numerical simulation method to reveal the evolution mechanism of fracture flow capacity,taking into account the wear of the fracture surface in shear simulations and the initial stress state of the rock in seepage simulations.This research explains the permeability evolution mechanism of fractured shale from a microscopic perspective,and the proposed numerical simulation method for shear seepage provides a powerful means to uncover the dynamic evolution mechanisms governing fracture permeability. 展开更多
关键词 Discrete element method(DEM) Finite element method(FEM) Fracture Permeability Shear stress Joint roughness coefficient(JRC) Dynamic evolution
暂未订购 下载PDF
Long-term real-world PM2.5 exposure induces depression-like behaviors in mice by disrupting nuclear factor erythroid 2-related factor 2-mediated astrocyte-to-microglia communication 认领 引用
3
作者 Nannan Huang Weiqing Shi +4 位作者 Cuishuang Dong Bin Li Yaohan Wang Hanqing Chen Xiaobo Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3238-3248,共11页
Long-term exposure to ambient fine particulate matter(PM2.5)may increase the risk of neurotoxicity in human populations.However,research studies on the underlying mechanisms of chronic PM2.5-induced depression-like be... Long-term exposure to ambient fine particulate matter(PM2.5)may increase the risk of neurotoxicity in human populations.However,research studies on the underlying mechanisms of chronic PM2.5-induced depression-like behaviors,and potential therapeutical strategies,remain scarce.In the present study,after long-term exposure to real-world PM2.5 for 15 weeks,male mice displayed depression-like behaviors,which were revealed using the open field and sucrose preference tests.Mechanistically,chronic PM2.5 exposure promoted astrocytic A1 polarization and disrupted reduction-oxidation balance in the mouse hippocampus.Furthermore,PM2.5-exposed mice displayed pathological damage to hippocampal neurons as well as the inhibition of nuclear factor erythroid 2-related factor 2 signaling.Astrocytic ablation of nuclear factor erythroid 2-related factor 2 exacerbated PM2.5-induced hippocampal neuronal injury in mice via the disruption of astrocyte-to-microglia communication;this finding was confirmed in mice with bilateral and unilateral hippocampal astrocytic Nfe2l2 knockdown.Importantly,the upregulation of nuclear factor erythroid 2-related factor 2 activation by procyanidin significantly ameliorated PM2.5-induced depression-like behaviors through the remodeling of astrocyte-to-microglia communication.Together,our findings shed light on the important role of hippocampal astrocytic nuclear factor erythroid 2-related factor 2 activation for maintaining astrocyte-to-microglia communication,and indicate potential research avenues for therapeutic strategies against PM2.5-induced depresson-like behaviors. 展开更多
关键词 air pollution astrocyte-to-microglia communication depression-like behaviors fine particulate matter(PM2.5) neurotoxicity nuclear factor erythroid 2-related factor 2 oxidative stress procyanidins
暂未订购 下载PDF
Cropping alfalfa for 18 years increases importance of fungi in multi-kingdom networks in saline-alkali soils 认领 引用
4
作者 Dan ZHU Bin LI +5 位作者 Lun AO Xiaoqian LIU Mengmeng ZHANG Guangyu SUN Junnan DING Xin LI 《Pedosphere》 SCIE CAS CSCD 2026年第3期802-817,共16页
Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricu... Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricultural ecosystems.In this study,an 18-year-old alfalfa cultivation area within the saline-alkali Songnen Plain in Northeast China was selected to determine the contribution of the microbial network to the improvement of saline-alkali soils after alfalfa cropping.Our findings indicated that the multi-kingdom microbial network,comprising fungi,bacteria,and archaea,was more complex and stable than the single-kingdom networks.Specifically,the multi-kingdom network exhibited an increased number of nodes and connections,demonstrating higher complexity.By cultivating alfalfa in saline-alkali soils,fungal nodes in the multi-kingdom network demonstrated significantly higher degree and betweenness compared to bacterial nodes and archaeal nodes.Additionally,fungi had a higher natural connectivity,which contributed to the overall network stability.In contrast,the bacterial subset in the multi-kingdom network in bare land exhibited a higher degree,betweenness,and natural connectivity.Furthermore,changes in the topological properties of the microbial network,including its complexity and stability,were significantly correlated with environmental factors,such as soil electrical conductivity and pH.In conclusion,cultivating alfalfa stabilized the self-organization in the multi-kingdom network in saline-alkaline soils and increased the complexity and stability of the fungal network.These findings provide a foundation for further research into the role of multi-kingdom microbial communities in soil ecosystems. 展开更多
关键词 microbial community microbial co-occurrence network network stability phytoremediation single-kingdom network soil salinization Songnen Plain topological property
暂未订购 下载PDF
Sedimentary heterogeneity-constrained differential diagenesis in fluvial tight sandstones:Implications for reservoir quality heterogeneity in sandbody architectural elements 认领 引用
5
作者 Pan-Ke Sun Shi-Yi Jiang +7 位作者 Rui-Feng Yan Li Liu Gang Tian Zeng Sheng Bin Li Rui-Feng Zhou Si-Cheng Zhu Lin Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2026年第3期1105-1137,共33页
Fluvial tight sandstones,as unconventional reservoirs,feature complex sedimentary,diagenetic,and reservoir quality heterogeneities that fundamentally control their exploration and development.This study focuses on typ... Fluvial tight sandstones,as unconventional reservoirs,feature complex sedimentary,diagenetic,and reservoir quality heterogeneities that fundamentally control their exploration and development.This study focuses on typical fluvial tight sandstones of the Shanxi Formation in northern Sulige Gas Field(Ordos Basin),using core samples,field sections,logging data,and analytical tests to investigate the coupling relationships among sedimentary,diagenetic,and reservoir quality heterogeneities.Results demonstrate that:the target layer in the study area develops six lithofacies,three braided river sandbody architectural elements,two meandering river sandbody architectural elements,and five diagenetic facies.Different architectural elements and their internal lithofacies exhibit differences and coupling relationships in the strengths of sedimentary heterogeneity and diagenetic heterogeneity.Specifically:strong compaction diagenetic facies primarily occurs in siltstone lithofacies of sand-dominated,weakly sedimentary heterogeneous architectural elements;strong dissolution+microfracture development diagenetic facies is mainly distributed in coarser-grained sandstones of sand-dominated architectural elements with low sedimentary heterogeneity;clay mineral intercrystalline pore-dominated diagenetic facies is primarily located near interbeds within all architectural elements;strong carbonate cementation diagenetic facies predominates in thick mudstones at the top/bottom of architectural elements,and at contacts with pure mudstone interbeds;strong clay mineral cementation diagenetic facies concentrates in medium-heterogeneity architectural elements near pure mudstone interbeds and at contacts with silty mudstone interbeds.Sedimentary and diagenetic heterogeneities jointly control reservoir quality distribution in all architectural elements(excluding basal conglomerates):porosity and permeability decrease in positive rhythm as lithofacies grain size fines,while irreducible water saturation increases in inverse rhythm.The findings of this study can provide a robust basis for the exploration and development deployment of fluvial tight sandstone reservoirs. 展开更多
关键词 Fluvial tight sandstone Reservoir quality Sedimentary heterogeneity Diagenetic heterogeneity Ordos Basin
暂未订购 下载PDF
Eu3+/Mn4+co-doped GdGeSbO6dual-emitting phosphor for multifunctional applications 认领 引用
6
作者 Chong Yang Bin Li +3 位作者 Rongbo Ma Bin Cao Chaoyong Deng Weichao Huang 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第4期1023-1034,I0002,共12页
Multifunctional phosphors have gained significant attention for their extensive application potential.In this work,novel Eu3+/Mn4+co-doped GdGeSbO6dual-emission phosphors were synthesized by high temperature ... Multifunctional phosphors have gained significant attention for their extensive application potential.In this work,novel Eu3+/Mn4+co-doped GdGeSbO6dual-emission phosphors were synthesized by high temperature solid-phase method.The crystal structure,optical properties,and temperature-sensing performance of these phosphors were systematically investigated.Under 463 nm excitation,GdGeSbO6:Eu3+,Mn4+phosphors have multiple emission peaks in the range of 500-800 nm,corresponding to the5D0→7FJ transition for Eu3+and the2E→4A2 transition for Mn4+,respectively.The optical temperature properties of GdGeSbO6:Eu3+,Mn4+were analyzed using fluorescence intensity ratio(FIR)analysis,and the maximum relative sensitivity at 423 K is found to be 2.73%/K.By integrating GdGeSbO6:Eu3+,Mn4+phosphors with near-UV light-emitting diode(LED)chips,a prototype LED device was successfully fabricated with a spectrum that significantly overlaps with the absorption curve of phytochrome.In addition,the anti-counterfeiting ink was prepared using GdGeSbO6:Eu3+,Mn4+phosphors,and they show tunable emission under different light stimulation.These results indicate that GdGeSbO6:Eu3+,Mn4+multifunctional phosphors have promising applications in optical thermometry,promoting plant growth and anti-counterfeiting. 展开更多
关键词 GdGeSbO6:Eu3+ Mn4+ Anti-counterfeiting inks Optical temperature measurement Plant growth Rare earths
暂未订购 下载PDF
The comparison of AICAR and exercise on mitochondrial quality control in hippocampus and cognitive function of aged mice 认领 引用
7
作者 Bo Liao Yuanyuan Qin +11 位作者 Shanyao Pan Guiping Wang Zhi Jiang Bin Li Yao Wang Yulong Wang Mingchao Zhou Yong Zhang Gang Liu Zhenghong Qin Xuefeng Xi Li Luo 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期164-176,共13页
Growing evidence suggests that exercise can provide neuroprotection by improving mitochondrial quality control(MQC)on the aged brain.Adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)signaling responsiven... Growing evidence suggests that exercise can provide neuroprotection by improving mitochondrial quality control(MQC)on the aged brain.Adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)signaling responsiveness declines with aging.However,whether AMPK plays a role in the exercise-mediated improvement of memory and MQC in the aged hippocampus remains to be established.5-Aminoimidazole 4-carboxamide ribonucleoside(AICAR),a pharmacological agonist of AMPK,has been proposed to be an exercise mimetic recently.However,it has not been clarified whether AICAR could mimic the effects of exercise on the aged hippocampus through improvement of MQC.In this study,AICAR(AMPK agonist)and Compound C(AMPK inhibitor)were used to investigate if AMPK plays a key role in exercise-induced improvement of MQC and if AICAR could act as an exercise mimetic through improvement of MQC in aged hippocampus.Both exercise and AICAR improved the memory of aged mice and increased AMPK phosphorylation in the aged hippocampus.Exercise,but not AICAR,improved mitochondrial respiratory function in the aged hippocampus and increased the microtubule associated protein 1 light chain 3(LC3)-II/LC3-I ratio and the protein expression of LC3-II and autophagy related protein 7(ATG7)in the lysate of whole hippocampal tissue.Both exercise and AICAR increased the ratio of LC3-II/LC3-I and the protein expression of LC3-II in the mitochondrial fractions of the hippocampus.Regarding mitochondrial dynamics,neither exercise training nor AICAR changed the protein level of mitofusin 2(Mfn2).Exercise,but not AICAR,increased the protein level of dynamin-related protein 1(Drp1).Furthermore,both exercise training and AICAR increased the protein level of peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α),a modulator of mitochondrial biogenesis.Compound C abolished the exercise-induced effects on memory in aged mice,AMPK phosphorylation,autophagy,mitophagy,and mitochondrial fission in the aged hippocampus.However,Compound C did not reverse the exercise-induced increase in PGC-1α protein levels in the aged hippocampus.Our data provide evidence that AMPK plays an important role in the exercise-induced improvement of memory and MQC in the hippocampus of aged mice.Importantly,we demonstrated for the first time that AICAR could partially mimetic the beneficial effects of endurance exercise on memory and MQC in the hippocampus of aged mice,and thus may be a promising exercise mimetic for counteracting brain aging. 展开更多
关键词 5-Aminoimidazole 4-carboxamide ribonucleoside Adenosine 5′-monophosphate-activated protein kinase(AMPK) Exercise Memory Mitochondrial quality control Hippocampus Aging
暂未订购 下载PDF
Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development 认领 引用
8
作者 Nan Han Ran Tao +12 位作者 Xi Cheng Hui Deng Jianxin Wang Xianyu Bian Jinzhu Zhou Xuejiao Zhu Min Sun Xuehan Zhang Mi Hu Rongli Guo Wei Wang Siyuan Ding Bin Li 《Virologica Sinica》 SCIE CAS CSCD 2026年第2期439-454,共16页
Group A rotaviruses(RVs)continue to be one of the most important pathogens causing severe acute gastroenteritis in infants and young animals worldwide.Recently,the prevalence of porcine RV(PoRV)from pig farms has stri... Group A rotaviruses(RVs)continue to be one of the most important pathogens causing severe acute gastroenteritis in infants and young animals worldwide.Recently,the prevalence of porcine RV(PoRV)from pig farms has strikingly increased,adversely affecting the swine industry,particularly with the G9 genotype of PoRV VP7 emerging as the predominant genotype spreading in China.Current vaccines against PoRV fail to provide sufficient protective immunity,necessitating urgent development of effective vaccines and antiviral drugs against PoRV.Here,we successfully established and improved the entirely plasmid-based reverse genetics(RG)system to rescue a G9 genotype of recombinant PoRV AHFY2022 strain(G9P[23]).Using the improved RG system,we rescued recombinant AHFY2022 harboring the fluorescent UnaG protein or nano-luciferase(NLuc)reporter within gene segment 7 that encodes non-structural protein 3(NSP3).Furthermore,we adopted the UnaG reporter virus to screen anti-PoRV drugs and identified two promising antiviral drugs,C8 and C9.Moreover,we generated the recombinant PoRV(rAHFY2022-G5-VP7)containing G5 genotype of VP7 from PoRV-positive samples in the backbone of AHFY2022 strain.The reassortant strain exhibited efficient replication and genetic stability.Mouse models were utilized to evaluate the immune responses elicited by rAHFY2022-G5-VP7 strain in vivo,revealing similar neutralizing antibodies and cellular immune response compared to the parental AHFY2022 strain in mice.Together,this study provides an important tool for screening potential anti-PoRV drugs and developing novel vaccines against prevalent PoRV strains. 展开更多
关键词 Reverse genetics Reporter virus Porcine rotavirus(PoRV) Antivirals Vaccine development
暂未订购 下载PDF
Enterococcus hirae QT4713 alleviated DSS-induced colitis by modulating gut microbiota and tryptophan metabolism in mice 认领 引用
9
作者 Xueni Fan Zhenjiang Liu +7 位作者 Wei Liu Diantong Li Tingting Zhao Dongxu Wen Xin Li Qi Wang Bin Li Xiaodan Huang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1905-1919,共15页
Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibit... Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibited high anti-inflammatory activity in vitro.After confirming its tolerance to gastrointestinal fluids and safety,we evaluated the effect of E.hirae QT4713 on IBD using a dextran sulfate sodium(DSS)-induced colitis mouse model and analyzed the microbial response through metagenomic and metabolomics.The results indicated that E.hirae QT4713 alleviated colitis symptoms by reducing oxidative stress in the serum and inflammatory cytokine levels in colonic tissue,particularly IL-1β(P<0.05).It also reduced structural damage,inflammatory infiltration,and epithelial cell apoptosis in the colon.Additionally,the strain increased the expression of MUC-2 and occludin in colonic tissue,which helped to protect the colonic barrier.Furthermore,intervention with E.hirae QT4713 enriched beneficial bacteria such as Bifidobacteria and Lactobacillus,increased the levels of butyric acid and propionic acid in the gut(P<0.05),regulated tryptophan metabolism,and promoted the production of its indole derivatives,including 3-indoleacetonitrile,3-indoleacrylic acid,and indole-3-lactic acid(P<0.05),thus alleviating colitis.These findings provide new insights into how probiotics,such as E.hirae QT4713,alleviated colitis in a gut microbiotaryptophan metabolism-dependent manner. 展开更多
关键词 Probiotic Anti-inflammatory Colitis Gut microbiota Tryptophan metabolism
暂未订购 下载PDF
Diffusion of polymer permeation grouting in water-rich sand layers:Mathematical model and experimental validation 认领 引用
10
作者 Jiasen Liang Xueming Du +5 位作者 Lei Wang Hongyuan Fang Xiaohua Zhao Bin Li Kejie Zhai Shanyong Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第5期3703-3721,共19页
Water-rich sand layers are frequently encountered as adverse geological conditions during underground construction.Polymer slurry grouting has been widely recognized as an effective technique for reducing permeability... Water-rich sand layers are frequently encountered as adverse geological conditions during underground construction.Polymer slurry grouting has been widely recognized as an effective technique for reducing permeability and enhancing the stability of such strata.In this study,a mathematical model is established to describe the diffusion behavior of polymer slurry in porous media under dynamic water conditions and is further validated through laboratory experiments.The theoretical formulation of the slurry permeation process is developed based on Darcy's law,the Hagen–Poiseuille flow principle,and the physicochemical characteristics of the slurry.The derivation primarily focuses on analyzing the dynamic response of the slurry under the influence of water flow,considering the effects of flow velocity,grouting pressure,and sand-layer porosity on diffusion behavior.To verify the proposed model,a visualized grouting simulation system was designed to observe the diffusion process of polymer slurry in water-rich sand layers.The results demonstrate that slurry diffusion is significantly affected by grouting pressure,porosity,and water flow velocity.The observed staged diffusion characteristics,dynamic evolution patterns,and directional effects are in good agreement with theoretical predictions.Furthermore,the average relative deviations between the theoretical and experimental results for diffusion pressure and diffusion distance are both less than 25%,confirming the reliability of the proposed model.Additionally,this study identifies distinct differences in slurry diffusion between porous and void media.In porous media,slurry propagation encounters greater hydraulic resistance,leading to rapid pressure attenuation and a limited diffusion range.Conversely,diffusion in void media occurs more smoothly due to the continuous cavity structure,resulting in slower pressure decay and a substantially larger diffusion radius.These findings elucidate the mechanisms governing slurry diffusion under dynamic water conditions and provide a theoretical basis for optimizing grouting parameters and improving construction efficiency in water-bearing strata. 展开更多
关键词 Water-rich sand layer Model derivation Permeation grouting Polymer slurry Diffusion mechanism
暂未订购 下载PDF
PARP9 Modulates Sunitinib Resistance in Clear Cell Renal Cell Carcinoma via STAT1/IRF1 Signaling Pathway 认领 引用
11
作者 Lei Luo Fengju Guan +4 位作者 Zhankun Wang Bin Li Xuemei Ding Leilei Song Lijiang Sun 《Oncology Research》 SCIE 2026年第7期666-687,共22页
Background:Resistance to sunitinib represents a major clinical obstacle in the management of clear cell renal cell carcinoma(ccRCC).This investigation aims to identify genes associated with sunitinib resistance and el... Background:Resistance to sunitinib represents a major clinical obstacle in the management of clear cell renal cell carcinoma(ccRCC).This investigation aims to identify genes associated with sunitinib resistance and elucidate potential molecular pathways in ccRCC.Methods:To identify differentially expressed genes(DEGs)in sunitinib-resistant ccRCC cells and their parental cells,bioinformatic analysis was performed on the GSE216494 dataset.Protein-protein interaction(PPI)network and topological analyses pinpointed a hub gene.Sunitinib-resistant A498 and 786-O cell lines were employed for in vitro validation.Sunitinib sensitivity and cell proliferation were evaluated using functional assays,such as colony formation and Cell Counting Kit-8(CCK-8).Protein interactions and signaling pathway activity are investigated using co-immunoprecipitation(Co-IP),dual-luciferase reporter assays,and immunofluorescence.In resistant cells and patient-derived organoids(PDOs),the therapeutic potential of olaparib,either by itself or in conjunction with sunitinib,was assessed.Results:Sunitinib-resistant cells and patient tissues were shown to exhibit consistent upregulation of poly(ADP-ribose)polymerase 9(PARP9).PARP9 knockdown sensitized resistant cells to sunitinib,suppressing proliferation.Conversely,its overexpression induced resistance in parental cells.Additionally,STAT1 and PARP9 interact to promote nuclear translocation and STAT1 phosphorylation.Activation of the STAT1/IRF1 axis further enhanced the expression of ISG15 and IFIT1.Olaparib treatment can increase sunitinib-resistant ccRCC cells.Olaparib can weaken the STAT1/IRF1 signaling pathway and prevent sunitinib-resistant ccRCC cells from proliferating.Importantly,combination treatment with olaparib and sunitinib showed superior antitumor efficacy in ccRCC PDOs.Conclusion:This study demonstrates that PARP9 promotes sunitinib resistance in ccRCC by activating the STAT1/IRF1 pathway and upregulating ISG15/IFIT1. 展开更多
关键词 Clear cell renal cell carcinoma PARP9 STAT1/IRF1 signaling pathway sunitinib resistance ISG15
暂未订购 下载PDF
Hydraulic Fracture Conductivity Loss Mechanisms for Unconsolidated Sands Considering Fine Migrations and Proppant Embedments 认领 引用
12
作者 Xian Shi Botao Zhang +5 位作者 Weidong Zhang Zenghua Ma Bo Zhang Ahmad Ramezanzadeh Bin Li Jian Mao 《Energy Engineering》 EI 2026年第5期416-433,共18页
To investigate the mechanism governing the continuous decline in fracture conductivity of unconsolidated sandstone reservoirs post-hydraulic fracturing,this study centers on the synergistic effects of two key mechani... To investigate the mechanism governing the continuous decline in fracture conductivity of unconsolidated sandstone reservoirs post-hydraulic fracturing,this study centers on the synergistic effects of two key mechanisms—particle migration and proppant embedment.Through the integration of laboratory experiments and computational fluid dynamics-discrete element method(CFD-DEM)coupled numerical simulations,this study systematically examines the influence patterns of varying closure pressures,particle concentrations,fluid properties,and proppant parameters on fracture conductivity.The experimental results demonstrate that particle migration induces pore blockage within the proppant packing layer.When the fines mass concentration reaches 10%,fracture conductivity is almost entirely lost.Furthermore,the embedment depth of proppants increases with increasing closure pressure,and the embedment depth of proppants with a high elastic modulus is twice that of those with a low elastic modulus under a closure pressure of 35 MPa.Numerical simulations further reveal that fluid viscosity and displacement rate significantly govern the migration range and blockage pattern of particles.When the fluid viscosity is 10 mPa·s and the displacement rate is 200 mL/min,a balance between fracturing construction efficiency and fracture damage can be attained.The coupled model developed in this study accurately predicts the attenuation law of fracture conductivity under the synergistic effect of these two mechanisms.This model addresses the gap in understanding the coupled effects of mechanisms in unconsolidated sandstone reservoirs in existing literature and provides a theoretical foundation and engineering guidance for parameter optimization in the fracturing design of such reservoirs. 展开更多
关键词 Fine migration proppant embedment fracture conductivity loss unconsolidated sandstone reservoir
暂未订购 下载PDF
Microglial metabolic reprogramming:Aucubin inhibits aldose reductase to reverse diabetic neuropathic pain 认领 引用 被引量：1
13
作者 Bin Li 《World Journal of Diabetes》 SCIE 2025年第8期339-344,共6页
This letter critically comments on the article by Zheng et al investigating the role of aucubin in alleviating diabetic neuropathic pain(DNP).DNP arises from hyperglycaemia-induced nerve injury and microglial reprogra... This letter critically comments on the article by Zheng et al investigating the role of aucubin in alleviating diabetic neuropathic pain(DNP).DNP arises from hyperglycaemia-induced nerve injury and microglial reprogramming toward aerobic glycolysis.Aldose reductase(also known as AKR1B1)redirects excess glucose flux through the polyol pathway,thus increasing oxidative stress and inflammation.Zheng et al show that aucubin,a plant iridoid glycoside,reverses streptozotocin-induced mechanical and thermal hypersensitivity and anxiety-like behaviour in mice.Mechanistically,aucubin restores microglial morphology,reduces glycolytic flux,enhances oxidative phosphorylation and lowers tumour necrosis factor-α,interleukin(IL)-1βand IL-6 levels in spinal tissue and cultures of the BV-2 microglial cell line.Network pharmacology and molecular docking analyses identify AKR1B1 as a key target,confirmed by the fact that short hairpin RNA knockdown of AKR1B1 eliminates the effects of aucubin.Contrary to the other studies,this study uniquely implicates the polyol pathway in microglial immunometabolism. 展开更多
关键词 Diabetic neuropathic pain Microglia Metabolism Aldose reductase Neuroinflammation
暂未订购 下载PDF
Efficient modulation of 5-AT/Sr(NO3)2 gas generator with a CuC2O4/CuO binary composite coolant for regulating the pyrolysis and combustion performances 认领 引用
14
作者 Siyuan Zhou Xuan Li +7 位作者 Yi Li Pengcheng Xi Haotian Zhou Dan Zhang Bin Li Lifeng Xie Mi Li Andrei Rotaru 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第7期299-316,共18页
Gas generators are systems that in certain emergency situations generate functional gases that are used for power sources,safety engineering,fire applications,and various other types of important gases,such as oxygen ... Gas generators are systems that in certain emergency situations generate functional gases that are used for power sources,safety engineering,fire applications,and various other types of important gases,such as oxygen or gaseous fuels.Green gas-producing agents in fire extinguishers,such as the 5-Amino Tetrazole(5-AT)exhibit low combustion stability.The regulation of temperature,rate,and stability of combustion is a key part of the combustion performance of the gas-producing agents;however,pre-vious studies found in the literature have focused mainly on one single modifier for isolated perfor-mance enhancement,whereas these three indexes are often trade-offs constraining each other.To regulate the overall performance of the gas-producing agent,copper oxalate(CuC2O4)and copper oxide(CuO)were selected as binary composite coolants.The obtained results indicate that the addition of coolant effectively promotes pyrolysis towards lower temperatures,accompanied by a decrease in the apparent activation energy corresponding to the pyrolysis process.Through a precise adjustment of the composition ratio of CuC2O4/CuO,the reduction of the combustion temperature exceeds 340°C,the adjustable burning rates span a range of 1.420.45 cm/s,and the controllable pressure exponent modulation is between 0.61 and 0.97.Also,the presence of CuC2O4/CuO induces a decrease in the average particle size of the condensed combustion products.The results of this study may provide a basis for the performance tuning and formulation design of gas-producing agents based on 5-AT for critical defence applications. 展开更多
关键词 5-Aminotetrazole Gas generator Combustion performance Coolant Kinetic study Pyrolysis Thermal analysis and calorimetry
暂未订购 下载PDF
PenCards:a global and community-contributed public archive of variant penetrance 认领 引用
15
作者 Zhaopo Zhu Ling Shang +7 位作者 Chuhan Shao Zheng Wang Xinxin Mao Yuanfeng Huang Pei Yu Bin Li Jinchen Li Guihu Zhao 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第2期332-342,共11页
Penetrance is a crucial indicator for accurately assessing disease risk and plays a vital role in disease research,gene therapy,and genetic counseling.However,with penetrance data dispersed across various sources,effi... Penetrance is a crucial indicator for accurately assessing disease risk and plays a vital role in disease research,gene therapy,and genetic counseling.However,with penetrance data dispersed across various sources,efficiently accessing and consolidating this information becomes a challenge.A comprehensive platform that integrates penetrance is urgently needed.Here,we present PenCards,a global,community-contributed public archive of variant penetrance,by first collecting penetrance data from all published literature and then using large international cohorts to specifically calculate the penetrance of autism-related variants.PenCards contains a total of 244,531 variants,including 239,244 single nucleotide variants,4994 insertions and deletions,and 293 copy number variants,covering approximately 300 phenotypes.We also provide a submission portal for the dynamic updating of penetrance.Additionally,to help users efficiently access genetic information,we comprehensively integrate over 150 variant-and gene-level resources.In summary,PenCards is a powerful platform designed to advance genetic research and diagnostics.PenCards is publicly available at http://gffzz423c9aaee4fd4edbs6fn5uw5qunnf6pvw.ffgz.tsg.suse.edu.cn/pencards/. 展开更多
关键词 Penetrance Disease risk Genetic research and diagnostics Secondary findings Human genomics
暂未订购 下载PDF
Review of short-to-ultrashort pulsed laser shock peening research:mechanisms,processes,and applications 认领 引用
16
作者 Wenhe Wang Xinlei Pan +10 位作者 Peng He Lei Xie Baosheng Tian Bin Li Hongwei Yang Yu Fu Yun He Qingyang Shen Hailong Cui Liucheng Zhou Yinghong Li 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第3期501-548,共48页
Laser shock peening(LSP)is an advanced surface strengthening technique crucial for enhancing the performance of critical components operating in extreme service environments.By generating gradient residual compressive... Laser shock peening(LSP)is an advanced surface strengthening technique crucial for enhancing the performance of critical components operating in extreme service environments.By generating gradient residual compressive stress and refining the microstructure via the interaction between the laser and metallic materials,LSP achieves multiscale modulation of the surface properties of metal components and considerably improves the fatigue,wear,and corrosion resistance of the material under demanding conditions.Owing to its noncontact surface modification process and properties,LSP has garnered considerable interest across fields such as aerospace,rail transit,biomedicine,and the nuclear industry.The pulse duration of the laser used in LSP considerably influences its interaction with metallic materials.Ultrashort-pulsed LSP exhibits extreme nonlinear,nonequilibrium,and multiscale time/space properties during its interaction with metallic materials,distinguishing it from short-pulsed LSP.However,existing reviews have predominantly analyzed LSP based on various factors,equipment,single performance,and applications.The pulse duration,which inevitably influences the application of LSP,has not been investigated yet.This review analyzes about 180 short-pulsed LSP and approximately 100 ultrashort-pulsed LSP papers published between 1963 and 2025 and focuses on the laser pulse duration to elucidate the existing status and prospective application value of short-and ultrashort-pulsed LSP from the viewpoints of mechanisms,processes,and applications.The associated challenges and prospects are examined and summarized using strengthening mechanisms,high-fidelity prediction models,process coupling innovations,and intelligent and efficient strengthening equipment.This work offers valuable insights for advancing laser manufacturing processes towards meeting the rigorous demands of extreme applications. 展开更多
关键词 short/ultrashort pulse duration laser-metal interaction laser shock peening process optimization
暂未订购 下载PDF
Synthesis,function,and application of plant-derived natural products in food 认领 引用
17
作者 Linshan Li Chi Shu +5 位作者 Jinlong Tian Wenwen Zeng Liang Wang Zhenyu Wang Qiuwei Zhao Bin Li 《Food Innovation and Advances》 2026年第1期13-25,共13页
Natural products are widely distributed across various organisms,and exhibit potent physiological activities.Among these,plant-derived natural products are extensively utilized in the food,pharmaceutical,and healthcar... Natural products are widely distributed across various organisms,and exhibit potent physiological activities.Among these,plant-derived natural products are extensively utilized in the food,pharmaceutical,and healthcare industries.Traditional extraction methods primarily rely on plant extraction but suffer from drawbacks such as low yield,long growth cycles,and high resource consumption.Consequently,microbial fermentation technology has emerged as an alternative solution,offering advantages including the ability to utilize abundant raw materials and its environmentally friendly and sustainable characteristics.This review summarizes recent advances in the biosynthesis and functional mechanisms of four classes of plant-derived natural products—alkaloids,terpenoids,phenylpropanoids,and polysaccharides—while also examining the challenges and future prospects for their practical applications. 展开更多
关键词 biosynthesis natural products plant extraction alkaloids terpenoids plant derived natural products microbial fermentation fermentation technology
暂未订购 下载PDF
Prospects and applications of efficient physical fields in enhancing quality stability of berries during processing:a review 认领 引用
18
作者 Chunting Qu Yuxi Lang +8 位作者 Hui Tan Yao Ma Xinwei Wang Honglin Jiang Maofan Yue Ziqi Song Ahmed Adel Ashour Bin Li Xu Si 《Food Innovation and Advances》 2026年第2期195-206,共12页
Berries are characterized by their high nutrient content and the presence of bioactive compounds.However,their thin skin and high moisture content render them highly susceptible to postharvest spoilage.Conventional pr... Berries are characterized by their high nutrient content and the presence of bioactive compounds.However,their thin skin and high moisture content render them highly susceptible to postharvest spoilage.Conventional processing methods can extend shelf life to a certain degree;however,they frequently result in nutrient loss,sensory quality deterioration,and increased energy consumption.In recent years,high-efficiency physical field technologies(such as acoustic field,electromagnetic fields,pressure field,and plasma)have provided new technological pathways for addressing the aforementioned challenges.The utilization of non-thermal or low-temperature processing characteristics enables the effective preservation of berry nutrients and flavor during critical stages,such as sterilization,drying,freezing,thawing,and refrigeration.Furthermore,these physical fields enhance processing efficiency,reduce energy consumption,and delay the deterioration of quality during storage.This paper systematically reviews the research progress in various physical fields of berry processing and quality enhancement,summarizing their fundamental concepts,mechanisms of action,and effects on berry quality across different processing stages,and discusses their prospects for industrial application in the food processing industry. 展开更多
关键词 physical field technologies such bioactive compoundshowevertheir postharvest spoilage acoustic fieldelectromagnetic fieldspressure berry processing processing methods efficient physical fields bioactive compounds
暂未订购 下载PDF
Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy 认领 引用
19
作者 Yi Wu Wei-Yi Wang +4 位作者 Jing-Qi Zhang Sai Wang Zhi Zeng Lu Fu Bin Li 《World Journal of Diabetes》 SCIE 2026年第1期147-163,共17页
BACKGROUND The incidence of diabetic cardiomyopathy(DCM)is increasing significantly as the population ages.DCM is one of the main causes of heart failure and mortality among patients with diabetes.Impaired mitophagy l... BACKGROUND The incidence of diabetic cardiomyopathy(DCM)is increasing significantly as the population ages.DCM is one of the main causes of heart failure and mortality among patients with diabetes.Impaired mitophagy leads to mitochondrial dysfunction,which in turn aggravates DCM progression.Microtubule affinityregulating kinase 4(MARK4)is a key regulator of autophagy in adipocytes.AIM To investigate the role of MARK4 in mitophagy in DCM.METHODS A mouse model of type 2 DCM was developed by administration of low-dose streptozotocin(50 mg/kg)combined with a high-fat diet.After 12 weeks MARK4 expression was knocked down in the mice by injection of the adeno-associated virus AAV9 into the tail vein.Four weeks later,cardiac function and structure were evaluated by echocardiography,and blood glucose levels and body weights were recorded.Mitochondrial ultrastructure and autophagosomes were assessed using electron microscopy.Mitochondrial membrane potentials were examined using fluorescence microscopy while the MARK4 and mitophagy-associated protein levels were investigated using western blotting.The downstream factors of MARK4 were identified using RNA-seq sequencing and bioinformatics with empirical confirmation.RESULTS MARK4 levels were markedly increased in the DCM animal and cardiomyocyte models.Downregulation of MARK4 in DCM mice reduced myocardial tissue injury,increased mitophagy,and mitigated damage to cardiac function.RNA-seq indicated that MARK4 downregulation promoted mitophagy via upregulation of UNC-51-like kinase 1,alleviating myocardial injury in mice.This was confirmed in cell rescue experiments.Bioinformatics predicted interaction between MARK4 and the autophagy marker protein microtubule-associated protein 1 light chain 3B.This was verified using co-immunoprecipitation.CONCLUSION Downregulation of MARK4 in DCM mice can reduce myocardial injury,protect mitochondrial function,and promote mitophagy by upregulating UNC-51-like kinase 1,protecting against cardiac damage. 展开更多
关键词 Microtubule affinity-regulating kinase 4 Diabetic cardiomyopathy Mitochondrial autophagy UNC-51-like kinase 1 Microtubule-associated protein 1 light chain 3B
暂未订购 下载PDF
Synthesis of hydrophilic magnetic molecularly imprinted polymers for selective recognition of laminarin in seaweeds 认领 引用
20
作者 Wang-Bin Zhang Tao-An Li +9 位作者 Chao Ma Xue-Ning Yang Qian-Yu Zhao Xiao-Qin Zhou Jie Chen Yong Liu Jian-Xin Min Hong-Dong Liu Bin Li Xin Yang 《Traditional Medicine Research》 2026年第10期11-19,共9页
Background:Laminarin,aβ-1,3-glucan derived from brown algae,possesses various bioactive properties.However,its conventional purification process is laborious and technically challenging.This study aimed to develop a ... Background:Laminarin,aβ-1,3-glucan derived from brown algae,possesses various bioactive properties.However,its conventional purification process is laborious and technically challenging.This study aimed to develop a novel method for the rapid and selective extraction of laminarin from seaweeds using magnetic molecularly imprinted polymers(MIPs).Methods:The magnetic MIPs were synthesized in an aqueous medium via surface radical polymerization.The synthesis employed laminarin as the template molecule,water-soluble VBTAC(4-vinylbenzyltrimethylammonium chloride)as the functional monomer,and MBA(N,N’-methylenebisacrylamide)as the crosslinker.The adsorption behavior of the polymers was evaluated,and the data were fitted to kinetic and isotherm models.Results:The adsorption process of laminarin onto the MIPs was best described by the pseudo-second-order kinetic model and the Langmuir isotherm model.Under optimized conditions,the polymers achieved a maximum adsorption capacity of 204.08μg·mg-1 with an imprinting factor of 1.33.Conclusion:The synthesized magnetic molecularly imprinted polymers demonstrated the ability to selectively and efficiently adsorb laminarin in empirical trials,offering a promising alternative to conventional purification methods. 展开更多
关键词 hydrophilic magnetic molecularly imprinted polymers laminarin specific selectivity extraction
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 51 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈