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Roadmap on sustainable materials and technologies 认领 引用
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作者 Jing Guo Chunhui Luo +49 位作者 Peng Li Mao Ye Zhihua Qiao Yubo Wu Huiqin Hu Xubiao Luo Liming Yang Yulin Cai Pengwei Li Kai Zhu Cheng Fu Bing Yu Yueying Chen Shichang Wang Ting Wang Chongchong Qi Zirou Liu Dongmei Huang Zengxi Wei Fangxin Mao Yi Wei Caining Wen Chao Han Bo Weng Han Feng Junming Hong Jing Wu Yu Xiao Guang Liu Linlin Song Rongzheng Ren Zhenhua Wang Long Kong Huaifang Shang Lihua Wang Yongzhi Chen Changjie Ou Huijun Yang Xiaoyu Liu Jin Yi Siwu Li Chuang Yu Yanhui Cao Zhong Wu Yida Deng Wenbin Hu Jianjian Zhong Xiong Zhang Yanwei Ma Jianmin Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期19-56,共38页
Sustainable development for our life is important task,which is driven by key materials and technologies.In this roadmap,we discuss three main aspects in addressing environmental questions,green chemical processes and... Sustainable development for our life is important task,which is driven by key materials and technologies.In this roadmap,we discuss three main aspects in addressing environmental questions,green chemical processes and energy challenges.They are included,such as gas treatment and separation,wastewater treatment,waste gas treatment,solid waste treatment,lithium extraction,hydrogen production,water splitting,CO2 reduction,photocatalytic clean technologies,plastic degradation,fuel cells,lithium batteries,sodium batteries,aqueous batteries,solid state batteries,metal air batteries and supercapacitors.Their status,challenges,progress and future perspectives are also discussed.We hope that this paper can give clear views on sustainable development in materials and technologies. 展开更多
关键词 Gas treatment and separation Waste treatment Lithium extraction Catalytic clean technologies Plastic degradation Batteries Supercapacitors
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Lactate alleviates intestinal barrier injury in weaned piglets via activation of the Wnt/β-catenin pathway and promotion of intestinal epithelial cell proliferation 认领 引用
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作者 Mingyu Wang Yifan Chen +10 位作者 Jiaojiao Chen Aimin Wu Daiwen Chen Bing Yu Jun He Jie Yu Xiangbing Mao Zhiqing Huang Yuheng Luo Junqiu Luo Ping Zheng 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期443-456,共14页
Background Inflammatory bowel disease causes intestinal structural damage,impairs gut function,hinders animal growth and development,and reduces farming efficiency.Previous studies demonstrated that lactate alleviates... Background Inflammatory bowel disease causes intestinal structural damage,impairs gut function,hinders animal growth and development,and reduces farming efficiency.Previous studies demonstrated that lactate alleviates dextran sulfate sodium(DSS)-induced inflammation and mitigates weight loss by enhancing intestinal barrier functions.However,the mechanisms underlying lactate-mediated protection of the intestinal epithelial barrier remain unclear.This study aimed to explore the protective effect of lactate on intestinal barrier damage in colitis piglets and the possible underlying mechanisms through in vivo and in vitro experiments.Methods A total of 6021-day-old weaned female piglets were randomly assigned into three groups based on weight:the control group(basal diet with physiological saline gavage),the DSS group(basal diet with 5%DSS gavage),and the DSS+LA group(2%lactate diet with 5%DSS gavage).There were 10 replicates per treatment,with 2 piglets per replicate.Jejunal morphology was assessed via hematoxylin and eosin staining,while Western blotting quantified the protein levels of proliferation markers,including cluster of differentiation 24(CD24),cyclin D1,and wingless/integrated(Wnt)/β-catenin signaling components.In vitro,0.08%DSS and 2–32 mmol/L sodium lactate-treated intestinal porcine epithelial cell line-J2(IPEC-J2)cells(n=4)were assessed for viability(Cell Counting Kit-8 assay),apoptosis(flow cytometry),and proliferation parameters,including cell cycle analysis and Leucine-rich repeat-containing G-protein coupled receptor 5(Lgr5+)stem cell quantification.Results In vivo,DSS administration induced jejunal villus shortening(P<0.05),downregulated protein levels of CD24,cyclin D1,casein kinase 1(CK1),and dishevelled-2(DVL2)(P<0.05).In vitro,DSS promoted apoptosis,inhibited proliferation,diminished the Lgr5+cell populations(P<0.05),and reduced S-phase cell proportions(P<0.05).Conversely,lactate supplementation ameliorated DSS-induced villus atrophy(P<0.05),restored CD24,cyclin D1,CK1,and DVL2 protein levels(P<0.05).Furthermore,in vitro,sodium lactate attenuated DSS-induced apoptosis(P<0.05),enhanced IPEC-J2 proliferation(P<0.05),expanded Lgr5+cells(P<0.05),and increased S-phase progression(P<0.05).Conclusions In summary,lactate ameliorated intestinal barrier damage in DSS-induced colitis by activating the Wnt/β-catenin pathway and restoring the balance between epithelial cell proliferation and apoptosis.This study provides novel mechanistic evidence supporting lactate's therapeutic potential for IBD management. 展开更多
关键词 Apoptosis Intestinal inflammation Lactate Lgr5 Piglets Proliferation Wnt/β-catenin pathway
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Oxygen Vacancy Engineering of Ultrafine ZnAl2O4 Nanoparticles as a Robust Protective Layer for Dendrite-Free and Long-Lifespan Aqueous Zn Metal Anodes 认领 引用
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作者 Yilun Ren Haifeng Bian +7 位作者 Qing Zhou Biao Wang Hao Wu Chunrong Zhao Bing Yu Rong Yang Jiantao Wang Xiangkang Meng 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期246-255,共10页
Aqueous zinc-ion batteries(AZIBs)hold great promise for safe and sustainable energy storage,but their commercialization is impeded by severe Zn dendrite growth and interfacial instability.To address these challenges,w... Aqueous zinc-ion batteries(AZIBs)hold great promise for safe and sustainable energy storage,but their commercialization is impeded by severe Zn dendrite growth and interfacial instability.To address these challenges,we propose a defect engineering strategy employing ultrafine ZnAl2O4(ZAO)nanoparticles(~5 nm)with oxygen vacancy defects as an artificial protective layer for Zn anodes.Synthesized via a scalable coprecipitation approach,the ZAO layer demonstrates exceptional Zn2+affinity and rapid ion diffusion,enabling uniform Zn deposition and suppressing parasitic reactions.Remarkably,the ZAO@Zn symmetric cell achieves an unprecedented cycling stability of 3600 h at 20 mA cm-2,outperforming most reported Zn anodes modified with metal oxyacid compounds.Moreover,the assembled ZAO@Zn//MnO2full cell retains a capacity of 166.5 mAh g-1after 1000 cycles at 2 A g-1.This work highlights that engineering oxygen vacancies in the ZAO layer is an effective strategy to enhance the performance and longevity of Zn anodes in AZIBs,paving the way for more reliable and efficient energy storage solutions. 展开更多
关键词 aqueous zinc-ion batteries dendrite growth oxygen vacancy defects side reactions ZnAl2O4
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Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid–AHR–NRF2 pathway activation 认领 引用
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作者 Cong Lan Wen Ren +4 位作者 Aimin Wu Bing Yu Jun He Yuheng Luo Daiwen Chen 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期279-298,共20页
Background Diarrhea remains a major health concern in both young animals and humans.Prevotella spp.,a dominant commensal genus in the healthy porcine gut,becomes increasingly abundant following weaning,suggesting a po... Background Diarrhea remains a major health concern in both young animals and humans.Prevotella spp.,a dominant commensal genus in the healthy porcine gut,becomes increasingly abundant following weaning,suggesting a potential role during this critical transitional period.However,its involvement in post-weaning diarrhea remains poorly understood.Here,we aim to elucidate the role and underlying mechanisms of Prevotella in alleviating diarrhea in weaned piglets.Results To model unsanitary housing conditions,piglets were housed in uncleaned pens containing residual fecal matter from previous occupants and exposed to cold stress by maintaining the ambient temperature at 19℃,below the optimal 28℃.Under these conditions,piglets were orally administered either a blank medium(CON,n=10×2)or Prevotella copri at 1×108CFU(Pc,n=10×2)on d 1,3,and 5.After 28 d,cold stress induced a diarrhea incidence of 33.45%in the CON group,while P.copri supplementation significantly reduced the diarrhea rate to 19.73%.Treatment with P.copri markedly improved intestinal morphology in the small intestine,decreased serum levels of lipopolysaccharide(LPS)and intestinal fatty acid-binding protein(i-FABP),and enhanced total antioxidant capacity(T-AOC)and catalase(CAT)activity.Quantitative PCR and 16S rRNA gene sequencing revealed that P.copri significantly increased the colonic abundance of Prevotella,reshaping both the composition and functional profile of the gut microbiota.Moreover,P.copri enhanced the modularity and robustness of microbial ecological networks.Untargeted metabolomic profiling of colonic contents revealed a significant enrichment of metabolites involved in the arachidonic acid pathway following P.copri supplementation.In parallel,untargeted metabolomics of P.copri culture supernatants identified differential metabolic pathways including metabolic pathways,biosynthesis of secondary metabolites,and biosynthesis of antibiotics.In vitro assays demonstrated that P.copri-derived metabolites inhibited the growth of three common porcine intestinal pathogens.Furthermore,both P.copri metabolites and arachidonic acid enhanced intestinal barrier integrity and suppressed TNF-α-induced inflammation and apoptosis in Caco-2 cells through activation of the AHR–Nrf2 signaling pathway.Conclusions These findings highlight the role of P.copri in maintaining gut homeostasis and provide new insights into microbiota-based interventions for early-life intestinal disorders. 展开更多
关键词 Arachidonic acid metabolism Diarrhea Microbial ecological network Prevotella copri
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Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m6A RNA methylation 认领 引用 被引量：1
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作者 Chan Liang Runqi Fu +6 位作者 Daiwen Chen Gang Tian Jun He Ping Zheng Jie Yu Junning Pu Bing Yu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期899-914,共16页
Background Low dietary energy levels can disrupt energy balance,causing metabolic disorders,particularly those involving in hepatic lipid metabolism.Betaine(BET),an important methyl donor,has demonstrated protective e... Background Low dietary energy levels can disrupt energy balance,causing metabolic disorders,particularly those involving in hepatic lipid metabolism.Betaine(BET),an important methyl donor,has demonstrated protective effects against liver diseases.However,its effects on hepatic lipid metabolism in pigs fed a low-net energy(NE)diet and the underlying mechanisms remain unclear.Thirty-two pigs(85.52±2.27 kg)were randomly assigned to four treatments:N-NE group(normal NE diet,2,475 kcal/kg NE),N-NEB group(normal NE diet+1,500 mg/kg BET,2,475 kcal/kg NE),R100-NE group(low-NE diet,2,375 kcal/kg NE),and R100-NEB group(low-NE diet+1,500 mg/kg BET,2,375 kcal/kg NE).The experiment lasted 35 d.Results There was no significant difference in growth performance among the groups(P>0.05).Reducing dietary NE levels caused liver dysfunction and increased total glyceride concentration,accompanied by lipid metabolism disorders.BET supplementation in a low-NE diet exhibited hepatoprotective roles,as evidenced by increased TP concentration and reduced ALT level in serum(P<0.05),as well as decreased fat content,adipocyte size,and total glyceride concentration in the liver(P<0.05).Meanwhile,dietary BET alleviated low-NE diet-induced hepatic lipid metabolism disorder by downregulating mRNA expressions of genes related to fatty acid transport(FABP3 and CD36)and lipogenesis(SREBP1c and FASN),while upregulating mRNA expressions involved in lipolysis(CPT1 and HSL)(P<0.05).Furthermore,dietary BET increased serum SAM concentration and the SAM/SAH ratio in pigs fed low-NE diets(P<0.05),thereby providing sufficient methyl groups through regulating the activities of enzymes participated in BET metabolism.Mechanistically,BET increased m6A modification level and regulated mRNA and protein expressions of m6A modified proteins including METTL3,METTL14,WTAP,YTHDF1,and ALKBH5.Correlation analysis showed a significant association between m6A RNA methylation and hepatic lipid metabolism,suggesting that m6A RNA methylation may play a critical role in mediating hepatic lipid metabolism.Conclusions Dietary BET supplementation in low-NE diets alleviated hepatic lipid metabolism disorders by regulating m6A RNA methylation,ultimately reducing hepatic lipid accumulation in finishing pigs. 展开更多
关键词 Betaine Finishing pig Lipid metabolism Liver Low energy diet m6A
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Dietary supplementation with Bacillus-based probiotic improves gut health in the weaned piglets challenged by rotavirus 认领 引用
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作者 Fengyu Xiang Heng Yang +15 位作者 Xiangqi Fan Dayan Tan Bing Huang Bing Yu Jun He Yuheng Luo Junqiu Luo Hui Yan Junning Pu Jianping Wang Quyuan Wang Huifen Wang John Kyaw Htoo Santa Maria Mendoza Guiling Yan Xiangbing Mao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期951-961,共11页
Background As probiotics,Bacillus strains may regulate some physiological functions in animals.This study aimed to evaluate whether dietary supplementation with a Bacillus-based probiotic could alleviate gut damage in... Background As probiotics,Bacillus strains may regulate some physiological functions in animals.This study aimed to evaluate whether dietary supplementation with a Bacillus-based probiotic could alleviate gut damage induced by rotavirus(RV)infection in piglets.Twenty-four piglets were randomly assigned into 2 groups fed with the basal diet(n=16)and the diet containing 109 colony-forming unit Bacillus spores/kg(n=8).On d 8,8 piglets fed with the diet supplemented with Bacillus-based probiotic and 8 piglets fed with basal diet were orally infused with RV,while the residue piglets had oral gavage of sterile essential medium.The trial duration was 12 d.Results RV challenge induced diarrhea,significantly destroyed the morphology of jejunal mucosa(P<0.05),significantly increased RV-antibody and RV non-structural protein 4 of jejunal mucosa(P<0.05),significantly impaired antioxidant capacity(including malondialdehyde level,total antioxidant capacity and catalase activity),immunity(such as interleukin 2,interleukin 4 and secreted immunoglobulin A levels),mucins and the m RNA expression of tightjunction-related(such as Zonula occludens 1,occludin)and apoptotic-related(including B-cell lymphoma/leukaemia-2-associated X protein,B cell lymphoma/leukaemia-2,cysteinyl aspartate specific proteinases)genes of jejunal mucosa(P<0.05),and,to some extents,affected the bacteria community structure and abundance of ileal digesta in piglets.However,Bacillus-based probiotic administration could significantly attenuate the negative effects of RV infection on gut health of piglets(P<0.05).Conclusions These findings suggested that supplementing Bacillus-based probiotic in the diet could decrease diarrhea rate,and improve gut health in weaned piglets,which was associated with regulating intestinal antioxidant capacity,apoptosis,and microbiota. 展开更多
关键词 Apoptosis Antioxidant capacity Bacillus strains Intestinal health Microbiota Rotavirus Weaned piglets
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Polyurethane-polysiloxane Copolymer Compatibilized SiR/TPU TPV with Comfortable Human Touch Toward Wearable Devices 认领 引用 被引量：5
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作者 Hong-Fang Zhang Qian Hao +6 位作者 Hong-Chi Tian Peng-Jun Yao Xue-Ying Liu Bing Yu Nan-Ying Ning Ming Tian Li-Qun Zhang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2023年第2期258-266,共9页
Because of its softness,wear resistance,biocompatibility,extremely comfortable human touch,thermoplastic vulcanizate(TPV)comprised of silicone rubber(SiR)and thermoplastic polyurethane(TPU)(SiR/TPU TPV)is especially s... Because of its softness,wear resistance,biocompatibility,extremely comfortable human touch,thermoplastic vulcanizate(TPV)comprised of silicone rubber(SiR)and thermoplastic polyurethane(TPU)(SiR/TPU TPV)is especially suitable for wearable intelligent devices.Nevertheless,developing good compatibilizer is still required to prepare high performance SiR/TPU TPV.In this study,three kinds of polyurethane-polysiloxane copolymer(PU-co-PSi)with different contents of polysiloxane segment were selected,and their compatibilization effect on SiR/TPU blends was studied using nanomechanical mapping technique of AFM.The results show that using PU-co-PSi with the highest content of polysiloxane segment(PU-co-HPSi),the interface thickness largely increases,and the average size of SiR dispersed phase largely decreases,indicating its good compatibilization effect.By using PU-co-HPSi as compatibilizer,SiR/TPU TPV with a fine SiR dispersed phase and good mechanical performance were successfully prepared.The mechanism on the compatibilization effect of these PU-co-PSi on SiR/TPU TPVs was revealed. 展开更多
关键词 Silicone rubber(SiR) Thermoplastic polyurethane(TPU) Compatibilization Thermoplastic vulcanizate(TPV)
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2014—2023年潍坊市日均气温与水痘发病关系:基于分布滞后非线性模型分析 认领 引用
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作者 李梓菡 彭鹏 +6 位作者 赵文嘉 邴瑜 殷大鹏 徐成东 胡跃华 栾桂杰 王园园 《医学新知》 CAS 2026年第2期132-137,共6页
目的 基于分布滞后非线性模型(DLNM)系统评估潍坊地区日均气温对水痘发病的非线性影响及其滞后效应。方法 收集2014年1月至2023年12月潍坊地区水痘病例监测数据和同期气象数据,运用DLNM模型分析日均气温与潍坊地区水痘发病的暴露-反应... 目的 基于分布滞后非线性模型(DLNM)系统评估潍坊地区日均气温对水痘发病的非线性影响及其滞后效应。方法 收集2014年1月至2023年12月潍坊地区水痘病例监测数据和同期气象数据,运用DLNM模型分析日均气温与潍坊地区水痘发病的暴露-反应关系。结果 研究期间潍坊市共报告水痘病例7 871例。日均气温与水痘日病例数呈负相关(rs=-0.235,P<0.001)。以日均温度的中位数15.69℃为参考值,低温情况下RR值较高。低温影响出现于滞后早期(滞后0~9 d),而高温影响则呈双阶段特征,在滞后早期(0~7 d)表现为较弱的危险因素,但在滞后后期(如14 d)则可能转变为保护因素。亚组分析发现水痘发病呈显著的季节异质性和年龄差异,3~6岁组冬季发病风险为夏季的1.9倍,表现出明显的季节性波动模式。敏感性分析表明模型结果稳健。结论 气温与潍坊市水痘就诊量之间呈非线性关系,低温对水痘发病影响显著且存在滞后效应;高温影响较为温和且呈现出双阶段特征。提示在冬春低温季节需重视预防水痘发病,特别是在学校和托幼机构等人群密集场所应加强防控措施。 展开更多
关键词 水痘 气象因素 气温 分布滞后非线性模型
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Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets 认领 引用 被引量：3
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作者 Junqiu Luo Xiu Wu +2 位作者 Daiwen Chen Bing Yu Jun He 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第1期377-387,共11页
Background Oxidative stress significantly impacts growth performance and liver function in piglets.Ferulic acid(FA)works as an antioxidant,however,the role and mechanism of FA in the regulation of diquat-induced oxida... Background Oxidative stress significantly impacts growth performance and liver function in piglets.Ferulic acid(FA)works as an antioxidant,however,the role and mechanism of FA in the regulation of diquat-induced oxidative stress in piglets are less known.This study was designed to investigate the effects of FA on growth performance and antioxi-dant capacity in piglets with diquat challenge.Methods Thirty-two healthy DLY(Duroc×Landrace×Yorkshire)piglets(13.24±0.19 kg)were randomly divided into one of two diets including 0 or 4 g/kg FA for 14 d.On d 15,all pigs were intraperitoneally injected diquat or sterile saline.Results Dietary supplementation with ferulic acid(FA)significantly improved the average daily gain(ADG)and decreased feed-gain ratio(F/G)of piglets.Here,dietary FA supplementation reduced serum aspartate aminotrans-ferase(AST),alanine aminotransferase(ALT)activities in diquat challenged piglets.Furthermore,diquat infusion increased reactive oxygen radicals(ROS)level in liver,decreased the activities of total superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC)and increased malondialdehyde(MDA)con-tent in the liver and serum.Supplementation with FA significantly increased T-AOC and T-SOD activities and decreased MDA and ROS levels.FA down-regulated gene and protein expression of Keap1,and up-regulated protein expression of Nrf2 and HO-1 in the liver of piglets with diquat challenge.Importantly,diquat challenge increased the ratio of late apoptosis,increased serum levels of IL-1β,IL-18 and lactate dehydrogenase(LDH),and up-regulated pyroptosis-related genes in the liver.FA supplementation reduced the ratio of late apoptosis and down-regulated mRNA expression of Caspase-1.Accordingly,FA addition reduced concentration of IL-1β,IL-18,and LDH under diquat challenge.Conclusions Diquat-induced oxidative stress reduced growth performance and impaired liver function in piglets.Dietary FA supplementation enhanced the antioxidant capacity and reduced the degree of hepatocyte pyroptosis,thereby alleviating the oxidative damage in the liver and mitigating the impact of diquat on growth performance of piglets. 展开更多
关键词 Antioxidant capacity Ferulic acid Hepatic pyroptosis Piglets
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Homogeneous catalysis and heterogeneous separation:Ionic liquids as recyclable photocatalysts for hydroacylation of olefins 认领 引用 被引量：2
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作者 Hao-Cong Li Ming Zhang +4 位作者 Qiyan Lv Kai Sun Xiao-Lan Chen Lingbo Qu Bing Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第2期389-393,共5页
The photoinduced ligand-to-metal charge transfer(LMCT)process has been extensively investigated,however,the recovery of photocatalysts has remained a persistent challenge in the field.In light of this issue,a novel ap... The photoinduced ligand-to-metal charge transfer(LMCT)process has been extensively investigated,however,the recovery of photocatalysts has remained a persistent challenge in the field.In light of this issue,a novel approach involving the development of iron-based ionic liquids as photocatalysts has been pursued for the first time,with the goal of simultaneously facilitating the LMCT process and addressing the issue of photocatalyst recovery.Remarkably,the iron-based ionic liquid 1-butyl-3-methylimidazolium tetrachloroferrate(C4mim-Fe Cl4)demonstrates exceptional recyclability and stability for the photocatalytic hydroacylation of olefins.This study will pave the way for new approaches to photocatalytic organic synthesis using ionic liquids as recyclable photocatalysts. 展开更多
关键词 LMCT Ionic liquids Homogeneous catalysis Heterogeneous separation Recyclable photocatalysts
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The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy 认领 引用 被引量：1
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作者 Han Wu Yumei Wang +3 位作者 Zekai Ren Hailin Cong Youqing Shen Bing Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第4期9-19,共11页
Glioma is the most common malignant tumor of the brain. The postoperative recurrence rate was high,and the 2-year survival rate only increased by 20%–25%. The reason is the blood-brain barrier(BBB). BBB is a physical... Glioma is the most common malignant tumor of the brain. The postoperative recurrence rate was high,and the 2-year survival rate only increased by 20%–25%. The reason is the blood-brain barrier(BBB). BBB is a physical barrier that stabilizes the physiological environment of brain tissue and protects the central nervous system from the invasion of harmful substances. Drug delivery based on nanotechnology and nanocarriers has attracted much attention due to its biological safety, continuous drug release time,increasing solubility, biological drug activity, and enhanced BBB permeability. By modifying different substances on the surface of nanocarriers, the BBB is bypassed by receptor-mediated and cell endocytosis and exocytosis. In addition, the purpose of bypassing BBB-targeted drug delivery can also be achieved by intranasal administration and local administration. This paper reviews different target transport mechanisms, mainly in invasive and non-invasive strategies, the nanocarriers that have made progress and the nanocarrier strategy of bypassing BBB are listed. 展开更多
关键词 Glioma Blood-brain barrier Nanocarriers Drug delivery Adsorption-mediated transport Receptor-mediated transport
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Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy 认领 引用
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作者 Min Zhang Ye Chen +5 位作者 Yanan Li Yifan Zhao Bai Lv Jie Cao Bing Yu Hailin Cong 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第12期41-50,共10页
Photothermal therapy(PTT),characterized by its minimally invasive nature and highly selective tumorkilling ability,holds great potential for tumor therapy.Due to the outstanding photothermal performance and tumor targ... Photothermal therapy(PTT),characterized by its minimally invasive nature and highly selective tumorkilling ability,holds great potential for tumor therapy.Due to the outstanding photothermal performance and tumor targeting ability,nanomaterial-based photothermal agents(nano-PTAs)have further expanded the therapeutic horizons of PTT.However,the dense and complicated network of the tumor extracellular matrix(ECM)severely restricts the penetration of nano-PTAs into deep tumor tissues.Since elevated temperatures are only generated in the vicinity of nano-PTAs upon laser irradiation,the uneven distribution of these agents leads to incomplete tumor coverage across the tumor.Consequently,overcoming ECM barriers and enhancing tumor permeability are critical for the success of tumor PTT.To address this challenge,researchers have explored strategies that combine tumor ECM regulation with PTT to facilitate the deep diffusion of nano-PTAs.This review summarizes the latest advancements in designing nanoPTAs with ECM-remodeling capabilities,aiming to enable their uniform penetration throughout tumors.Additionally,we discuss the remaining obstacles and challenges in elucidating the mechanisms of ECM manipulation and understanding the interactions between nano-PTAs and ECM components during the penetration process. 展开更多
关键词 ECM remodeling Tumor PTT Enlarged tumor permeability Uniform PTA distribution Improved PTA delivery efficiency
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Potassium-modified carbon nitride photocatalyzed-aminoacylation of N-sulfonyl ketimines 认领 引用
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作者 Cailing Wu Shaojie Wu +4 位作者 Qifei Huang Kai Sun Xianqiang Huang Jianji Wang Bing Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第2期378-383,共6页
The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical engineering.This research presents a new catalytic method for the... The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical engineering.This research presents a new catalytic method for the aminoacylation of N-sulfonyl ketimines by utilizing a potassium-doped graphite-like carbon nitride(g-C3N4)framework.This method not only enhances the catalytic efficiency and broadens the light absorption spectrum of g-C3N4but also significantly reduces the recombination rate of electronhole pairs,thereby increasing the reaction yield and selectivity.Importantly,our approach facilitates the synthesis of aminoacylated N-heterocycles,expanding the applicability of potassium-modified g-C3N4in photocatalytic organic synthesis.A notable accomplishment of this study is the unprecedented generation of carbamoyl radicals via heterogeneous photocatalysis,which can be easily recycled after reaction.This advancement highlights the capability of potassium-doped g-C3N4(namely K-CN)as an advanced heterogeneous photocatalyst for the formation of complex organic compounds. 展开更多
关键词 Photocatalysis Amides Oxamic acids Aminoacylation K+-modified carbon nitride
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Controlling the extent of nanoparticle occlusion within calcite crystals via surface chemistry engineering 认领 引用
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作者 Xia Sun Zixian Liang +6 位作者 Jiahao Zhang Boxiang Peng Bing Yu Pei Liu Biao Xiong Jizhuang Wang Yin Ning 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第9期367-371,共5页
Directly occluding polymer nanoparticles into growing host crystals provides a versatile pathway for synthe sizing polymer-inorganic composite crystals,where guest nanoparticles are distributed within the crystal matr... Directly occluding polymer nanoparticles into growing host crystals provides a versatile pathway for synthe sizing polymer-inorganic composite crystals,where guest nanoparticles are distributed within the crystal matrix.However,systematically controlling the extent of nanoparticle occlusion within a host crystal remains a significant challenge.In this study,we employ a one-step,soap-free emulsion polymerization method to synthesize polyethyleneimine-functionalized poly(tert-butyl methacrylate)(PtBMA/PEI)nanoparticles.These cationic nanoparticles are subsequently modified using formaldehyde to systematically tune the content of surface amine group via the Eschweiler-Clarke reaction.This approach yields a series of model nanoparticles that allow us to investigate how surface chemistry influences the extent of nanoparticle occlusion within calcite crystals.Our findings reveal that the extent of nanoparticle occlusion within calcite crystals is proportional to the surface amine group content.This study offers a new design rule for creating composite crystals with tailored compositions through a nanoparticle occlusion strategy. 展开更多
关键词 Nanoparticle occlusion Composite crystal Cationic nanoparticle Surface chemistry Nanocomposite
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用于输送带修补胶的室温固化聚氨酯的制备与性能研究 认领 引用
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作者 赵彤 冯桐伟 +3 位作者 孟阳 赵成哲 于冰 田明 《高分子学报》 SCIE CAS CSCD 北大核心 2026年第1期157-167,共11页
橡胶输送带常受到磨损而影响正常使用,通常使用浇注型聚氨酯等材料作为修补胶对磨损处进行现场修补,但现有聚氨酯修补胶对橡胶的粘接强度难以满足实际需求,且浇注型聚氨酯的结构组成与粘接强度间关系的研究尚不完善.基于此,本工作利用... 橡胶输送带常受到磨损而影响正常使用,通常使用浇注型聚氨酯等材料作为修补胶对磨损处进行现场修补,但现有聚氨酯修补胶对橡胶的粘接强度难以满足实际需求,且浇注型聚氨酯的结构组成与粘接强度间关系的研究尚不完善.基于此,本工作利用预聚体法成功制备了可室温固化的聚氨酯涂层,并同时从分子内聚力、润湿能力、粘接界面微观结构等角度对涂层与橡胶间的粘接性能展开研究.研究结果显示:硬段含量越高,分子内聚力越强,浇注型聚氨酯固化后形成的涂层对橡胶基体越容易形成更好的附着,T型剥离强度最高可达11.73 N/mm;低黏度浇注型聚氨酯有利于形成良好附着,适合的附着层厚度是良好粘接的关键.除此之外,本工作还研究了软硬段含量对浇注型聚氨酯涂层的拉伸性能、耐磨性能及硬度的影响,为浇注型聚氨酯涂层的制备与性能调控提供了理论支持.该聚氨酯涂层预期可作为橡胶修补胶,实现对橡胶输送带的室温快速修补. 展开更多
关键词 浇注型聚氨酯 室温固化 软硬段含量 黏度 内聚力
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Guideline of precisional testing in intrahepatic cholangiocarcinoma:an international expert consensus 认领 引用
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作者 Xin Zhang Jing Han +13 位作者 Ruoyu Shi Bing Yu Xuchen Zhang Bin Li Xia Sheng Zengshan Li Yining Zou Huichuan Sun Guoming Shi Hanlin LWang Jian Zhou Jia Fan Wenming Cong Yuan Ji 《Clinical Cancer Bulletin》 2025年第1期80-93,共14页
Intrahepatic cholangiocarcinoma(ICC)is a highly heterogeneous tumor.Molecular profiling serves as the foundation for personalized treatment of ICC.Comprehensive molecular testing is needed to identify more patients th... Intrahepatic cholangiocarcinoma(ICC)is a highly heterogeneous tumor.Molecular profiling serves as the foundation for personalized treatment of ICC.Comprehensive molecular testing is needed to identify more patients that are suitable for specific targeted therapies.This consensus is based on clinical data from both domestic and international sources,tailored to the Chinese context,and focuses on key targets for ICC.We present 15 recommendations aimed at guiding the precision detection of ICC. 展开更多
关键词 Intrahepatic cholangiocarcinoma Precision detection Biomarkers Personalized treatment
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A Wideband High-Gain Antenna for Low-Altitude UAV Airspace Control 认领 引用
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作者 Bing Yu Xiaoxin Yang +2 位作者 Fei Liu Jiang Shang Yan Li 《Instrumentation》 2025年第3期88-96,共9页
This paper proposes a portable broadband high-gain antenna for unmanned aerial vehicle(UAV)low-altitude control,operating within the dedicated remotely piloted aircraft system(RPAS)band(5.03–5.91 GHz).The total size ... This paper proposes a portable broadband high-gain antenna for unmanned aerial vehicle(UAV)low-altitude control,operating within the dedicated remotely piloted aircraft system(RPAS)band(5.03–5.91 GHz).The total size of the antenna is 240×240×187 mm3.It uses a printed log-periodic dipole antenna(PLPDA)as feed,and a four-layer frequency selective surface(FSS)cascaded as radome to enhance gain.Experimental results demonstrate that the antenna gain ranges from 10.1 to 15.9 dB and the half-power beam width(HPBW,2θ0.5)<23°within the operation band.Compared to existing portable UAV low-altitude control systems,the proposed antenna achieves an average gain enhancement of 4.7 dB. 展开更多
关键词 unmanned aerial vehicle(UAV) low-altitude control antenna frequency selective surface(FSS)
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Dynamic chiral Eu(Ⅲ) complex emitters with molecular rotor-regulated aggregation-enhanced antenna effects for high-resolution bioimaging 认领 引用 被引量：2
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作者 Wen-Wen Qin Bing Yu +4 位作者 Guan-Huang Zhang Meng-Juan Tang Hua-Hong Zou Fu-Pei Liang Zhong-Hong Zhu 《Rare Metals》 SCIE EI CAS CSCD 2025年第12期10390-10403,共14页
In this study,the arrangement,configuration,and distance of molecular rotors in the chiral Eu(Ⅲ)complex structure were regulated to achieve an aggregation-enhanced antenna effect,substantially improving the luminesce... In this study,the arrangement,configuration,and distance of molecular rotors in the chiral Eu(Ⅲ)complex structure were regulated to achieve an aggregation-enhanced antenna effect,substantially improving the luminescence intensity,circularly polarized luminescence(CPL),and bioimaging performance of Eu(Ⅲ) complexes.In the aggregated state,the rotor structure of R/S-Eu-YZZ-1 was anchored inside the structure and could not rotate due to the combined effects of strong hydrogen bonding,π-π interactions,and steric effects,which promoted intersystem crossing and enhanced the "antenna effect," thereby improving their emission intensity,luminescence asymmetry factor(glum),and CPL brightness(BCPL).The glum and BCPL of R/S-Eu-YZZ-1 were simultaneously improved,reaching values as high as 0.011/0.047 and 82.10/342.92 M-1 cm-1,respectively.The optical imaging performance of the monolayer chiral isomer R/S-Eu-YZZ-1 was considerably better than that of the bilayer R/S-Eu-YZZ-2 in both in vitro cellular and zebrafish in vivo experiments,indicating that the aggregation-enhanced antenna effect could enhance the bioimaging applications of chiral Eu(Ⅲ) complexes. 展开更多
关键词 Chiral Eu(III)complex emitters Circularly polarized luminescence Aggregation-enhanced antenna effect Molecular rotor Solvothermal synthesis
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Unlocking the power of swine gut bacteria:newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS‑induced colitis in mice 认领 引用 被引量：1
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作者 Jiatong Wei Yang Liu +20 位作者 Hua Li Ze Lu Yanjiao Liu Yifan Zhang Cong Lan Aimin Wu Jun He Jingyi Cai Gang Tian Daiwen Chen Bing Yu Zhiqing Huang Ping Zheng Xiangbing Mao Jie Yu Junqiu Luo Hui Yan Jiayong Tang Huifen Wang Quyuan Wang Yuheng Luo 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第5期2213-2233,共21页
Background Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals.In the quest for effective alternatives to antibiotics,next-generation probiotics(NGPs)have emerged as... Background Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals.In the quest for effective alternatives to antibiotics,next-generation probiotics(NGPs)have emerged as a promising option.The genus Blautia presents a rich source of potential NGP strains.Here we successfully isolated Blautia hominis LYH1 strain from the intestines of healthy weaned piglets and characterized its biological traits.Its antiinflammatory activity was then assessed using macrophages,while its protective effects against colitis and gut barrier damage were validated in a DSS-induced mouse colitis model.Results B.hominis LYH1 displayed typical characteristics of an obligate anaerobe,including non-hemolytic and nonmotile features,and a genome enriched with carbohydrate-active enzyme genes.It produced metabolites with antibiotic-like compounds,demonstrating antimicrobial activity against Escherichia coli.In vitro,B.hominis LYH1 effectively inhibited pathogen replication in macrophages,reducing cellular infections and alleviating inflammatory damage.In vivo,oral administration of B.hominis LYH1 or its metabolites significantly mitigated DSS-induced colitis in mice by suppressing pro-inflammatory cytokines,inhibiting T-lymphocyte activation,and enhancing short-chain fatty acid production.Conclusions Our findings underscore B.hominis LYH1’s potential as a NGP for maintaining gut health and combating intestinal inflammation.These findings offer valuable insights into the development of antibiotic alternatives and innovative strategies for preventing and treating enteritis in both agricultural and medical settings. 展开更多
关键词 Blautia hominis Colitis Inflammation Macrophage
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Designing a portable and accessible diffuse reflectance spectroscopy system for real-time detection of cervical intraepithelial neoplasia 认领 引用
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作者 Allison Scarbrough Diana Moses +1 位作者 Tongtong Lu Bing Yu 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第4期145-157,共13页
Significance:Over 80%of cervical cancer cases occur in lower-to-middle income countries(LMIC’s).This is partly because current screening techniques lack affordability,accessibility,and/or reliability for use in LMIC... Significance:Over 80%of cervical cancer cases occur in lower-to-middle income countries(LMIC’s).This is partly because current screening techniques lack affordability,accessibility,and/or reliability for use in LMIC’s.Aim:To develop an optical technique for cervical cancer screening that is affordable,accessible,and reliable for use in LMIC’s.Approach:We developed a portable diffuse reflectance spectroscopy(DRS)system,which costs$<2500 USD to manufacture,and employs a Raspberry Pi to extract the absorption(μα)and reduced scattering(μ′s)coefficients of biological tissue.The system was subject to travel and intentional rough handling.It was further used to capture 320 DRS spectra taken from 64 tissue-mimicking phantoms.Two users collected phantom data,one“expert”,and one“novice”in biomedical optics.The system was also used to collect 335 spectra from colon,small intestine,and rectal tissue of a fresh ex vivo porcine specimen.A previously described artificial intelligence model was used to extract optical properties,and a GradientBoostingClassifier identified the organ of origin for ex vivo spectra.Results:System alignment was robust to intentional rough handling and travel.Phantomμαandμ′s were predicted with average root-mean square error of<10%,regardless of user.Regarding ex vivo data,the system predicted the organ of origin with 80–90%accuracy.Statistical differences between predicted wereμαobserved in all three organs(P<0.001–0.03),and betweenμ′s in two organs(P<0.001–0.07).Conclusions:The DRS system has the potential to be affordable,reliable,and accessible for cervical screening in LMIC’s. 展开更多
关键词 Cervical cancer global health Raspberry Pi arti¯cial intelligence cancer screening
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