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Adaptive weight strategy for frequency-decomposed seismic attribute fusion in predicting of complex sand body distributions 认领 引用 被引量：1
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作者 Hong-Li Wu Sheng-He Wu +7 位作者 Zhen-Hua Xu Ming-Cheng Liu Bo Yang De-GangWu Zi-Shi Xie Yu Tang Xiao-Long Wan Xin-Ping Zhou 《Petroleum Science》 SCIE EI CAS CSCD 2026年第5期2367-2389,共23页
High-precision sand prediction is fundamental to improving the efficiency of oil and gas exploration and development.To address the limitations of traditional fixed-weight fusion strategies,particularly under conditio... High-precision sand prediction is fundamental to improving the efficiency of oil and gas exploration and development.To address the limitations of traditional fixed-weight fusion strategies,particularly under conditions of significant lateral variation in sand body distribution,this study proposesa dynamic weightingdeep neural network(DW-DNN)for adaptive frequency-decomposed attribute fusion.The approach integrates physical constraints with deep learning and introduces two innovations:(i)a priori weight matrices derived from the amplitudefrequency and tuning thickness relationship(amplitude variation with frequency,AvF)are embeddedintothe attention mechanism to adaptivelyallocate multiband seismic attributes,emphasizing high-frequency features for thin sands and low-frequency features for thick sands;and(ii)a deep neural network with a composite loss function combining mean squared error(MSE)and AVF-based constraints is designed to jointly optimize weight allocation and prediction accuracy.The method was applied to the Xi 233 area of theQingcheng Oilfield in the Ordos Basin and compared with conventional approaches.DW-DNN achieved high accuracy and generalizability,with an R2 of 0.92 in the 30%blind-well test,24.3%higher than conventional methods.In addition,91%of well-point errors were within 03 m,while prediction accuracies for thin(≤3 m)and thick(>3 m)sands reached 88%and 91%,respectively.The model also maintained stable performance under low well-control conditions(training-test ratio 5:5).Predicted sand distributions exhibited improved continuity and geologically plausible geometries,clearly delineating channels,lobes,and estuary bars.The results demonstrate that DW-DNN enhances frequency-decomposed attribute fusion through adaptive weight allocation,providing a robust tool for predicting sand body distributions in complex reservoirs. 展开更多
关键词 Reservoir heterogeneity Sand thickness prediction Frequency-decomposed attribute intelligent fusion Adaptive weighting Deep neural network
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Self-propelled biomotors co-deliver doxorubicin liposomes and aPD-1 antibody to fight breast cancer 认领 引用
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作者 Jia Wang Yunxiu Fan +9 位作者 Shilin Xu Zhouxue Wu Tian Hu Yun Lu Yue Li Kang Xiong Hongjun Deng Jingrong Huang Bo Yang Shaozhi Fu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期375-378,共4页
Although the combination of chemotherapy and immunotherapy can improve the treatment of breast cancer,traditional drugs are highly toxic because they do not specifically target tumors.In this study,we developed a self... Although the combination of chemotherapy and immunotherapy can improve the treatment of breast cancer,traditional drugs are highly toxic because they do not specifically target tumors.In this study,we developed a self-driving bacteriaanoparticle biohybrid called Bif@PDA-aPD1/DOX-Lip by attaching polydopamine(PDA)coated doxorubicin(DOX)liposomes and the immune checkpoint inhibitor anti-programmed cell death protein 1 antibody(aPD-1)to Bifidobacterium infantis(B.infantis,Bif).Using the homing abilities of bacteria,Bif@PDA-aPD1/DOX-Lip could actively accumulate in tumor tissue,releasing DOX and aPD-1 in the acidic environment to have a synergistic anti-tumor effect.Results show that the concentration of DOX in tumors of the Bif@PDA-aPD1/DOX-Lip group was 6.31 times higher than in the free DOX group.The combination of DOX and aPD-1 not only killed tumor cells but also promoted immune normalization by maturing dendritic cells(DCs),increasing M1 macrophage ratio,and enhancing infiltration of CD8+ and CD4+T cells in tumors and spleen.Therefore,Bif@PDA-aPD1/DOX-Lip therapy significantly inhibited tumor growth and increased the average survival time of mice to over 80 days.The Bif@PDA-aPD1/DOX-Lip biomotors offer a highly effective method for enhancing chemo-immunotherapy in solid tumors. 展开更多
关键词 Anaerobic bacteria Liposome Doxorubicin Anti-PD-1 antibody Chemo-immunotherapy Breast cancer
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Microstructural evolution and mechanical properties of the niobium alloy/GH4099 diffusion-bonded joints 认领 引用
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作者 Runjie Wang Bo Yang +6 位作者 Chun Li Hao Yuan Lei Chen Haoran Yang Xiaoqing Si Junlei Qi Jian Cao 《China Welding》 CAS 2026年第2期26-33,共8页
Niobium alloy and nickel-based superalloy exhibit high strength and remarkable corrosion resistance,joining them to fabricate composite structures could help to realize their potential.Nevertheless,research attention ... Niobium alloy and nickel-based superalloy exhibit high strength and remarkable corrosion resistance,joining them to fabricate composite structures could help to realize their potential.Nevertheless,research attention devoted to the joining of niobium alloy with nickel-based superalloy remains scarce.This study investigates direct diffusion bonding of these two materials.The microstructure of the joint is characterized in detail,with the typical joint microstructure being identified as GH4099/(Ni,Cr)ss+Ni3Nb+Cr2Nb/Ni3Nb/Ni6Nb7/Nb alloy.With holding time fixed at 60 min and diffusion pressure maintained at 15 MPa,the effects of diffusion bonding temperature on the microstructure and mechanical properties of joints are examined within the range of 900–1150℃.An increase in bonding temperature results in the formation of different intermetallic compounds within the joint.The primary cause of joint fracture is the presence of Cr2Nb and Ni6Nb7.The tensile strength of the joint initially increases and then decreases with increasing temperature,reaching a maximum value of 204 MPa.This work expands the range of methods for joining niobium alloys to nickel-based superalloys,enabling bonding without the introduction of additional elements. 展开更多
关键词 Diffusion bonding Niobium alloy Nickel-based superalloys Microstructure Tensile strength Intermetallic
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A novel single-port robotic system in urology:A prospective multicenter single-arm clinical trial evaluating feasibility and efficacy of first 50 cases 认领 引用 被引量：4
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作者 Zheng Wang Chao Zhang +16 位作者 Taile Jing Yong Wei Chengwu Xiao Yang Wang Yu Fang Xiaofeng Wu Shouyan Tang Hong Xu Yi Liu Bo Yang Shuo Wang Bin Xu Qingyi Zhu Dan Xia Zhenjie Wu Xiaofeng Gao Linhui Wang 《Asian Journal of Urology》 CAS CSCD 2025年第2期152-161,共10页
Objective:This study aimed to assess the feasibility and safety of the SHURUI single-port robotic surgical system for a range of major urological surgeries.Methods:In this prospective,multicenter clinical trial,we exa... Objective:This study aimed to assess the feasibility and safety of the SHURUI single-port robotic surgical system for a range of major urological surgeries.Methods:In this prospective,multicenter clinical trial,we examined the effectiveness of the SHURUI single-port robotic surgical system in urological interventions.The first 50 patients from four centers in China underwent single-port surgeries including partial nephrectomy,radical prostatectomy,partial adrenalectomy,and pyeloureteroplasty,exclusively by the SHURUI single-port robotic surgical system.The study's primary endpoints focused on the success of surgeries,defined as no deviations from planned procedures,no need for more than one port,and no re-operations within 24 h after surgery.Secondary endpoints encompassed a range of surgical metrics,functional outcomes,and patient demographic data.Clinical assessments were conducted before surgery,before discharge,and 1 month after discharge.Results:The surgical procedures were executed successfully without requiring intraoperative conversions or transfusions.Both estimated blood loss and operation durations were maintained within satisfactory limits.For each type of surgery,the mean console times and estimated blood loss were 179.8(standard deviation[SD]39.4)min and 125.6(SD 126.0)mL for radical prostatectomy,126.7(SD 47.8)min and 39.2(SD 54.4)mL for partial nephrectomy,112.6(SD 37.4)min and 20.0(SD 13.2)mL for partial adrenalectomy,and 148.0(SD 18.2)min and 18.0(SD 17.9)mL for pyeloureteroplasty,respectively.Across the cohort,17 patients experienced a total of 25 adverse events,while 10 postoperative complications,all rated as Clavien-Dindo grade I,were encountered by eight patients.All patients had shown recovery or improvement from these events before the end of this trial.Conclusion:The SHURUI single-port robotic surgical system demonstrated feasibility and safety in the performance of major urological surgeries.These initial findings highlight the system's potential,though further research and longer follow-up are required to assess long-term outcomes. 展开更多
关键词 Laparoendoscopic single-site surgery Single-port Robotic surgery Prostatectomy Nephrectomy Adrenalectomy Pyeloureteroplasty Clinical trial
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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption 认领 引用 被引量：3
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作者 Bowen Li Mengfan Ding +7 位作者 Xiaoming Liu Haiqin Chen Jianxin Zhao RPaul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第1期307-331,共25页
This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice.Newborn BALB/c mice were assigned to the control group(administration s... This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice.Newborn BALB/c mice were assigned to the control group(administration saline)and the CCFM1078 group(administration B.breve CCFM1078,3×109 CFU/day)in 3-,4-,and 5-week tests.All the groups have male and female distinctions.Our findings demonstrate that B.breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites(hexadecanamide,linoleoyl ethanolamide,and palmitoyl ethanolamide),the genes and proteins expression related to the growth hormone(GH)/insulin-like growth factors-1(IGF-1)axis and Gs/PKA/CREB signaling pathways,as well as downstream osteogenic and osteoclastic differentiation factors.The effects of B.breve CCFM1078 were different with age and gender dependent.This finding suggests B.breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population. 展开更多
关键词 Bifidobacterium breve Bone development Gut microbiota GH/IGF-1 axis Gs/PKA/CREB signaling pathway
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AI-Driven Interaction and Collaborative Optimization of Vehicle,Charging Station and Grid:Challenges and Prospects 认领 引用
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作者 Bo Yang Zhe Jiang +3 位作者 Jianfeng Wen Ning Yang Kaiping Qu Shuai Zhou 《Energy Engineering》 EI 2025年第6期2187-2195,共9页
1 Introduction Amid escalating global climate change,the“dual carbon”goals of carbon peak and carbon neutrality have become a focal point of global attention and an important strategy for sustainable development[1].... 1 Introduction Amid escalating global climate change,the“dual carbon”goals of carbon peak and carbon neutrality have become a focal point of global attention and an important strategy for sustainable development[1].With the rapid development of renewable energy technologies and the increasing public demand for environmental protection and low-carbon living,the adoption of new energy vehicles,particularly electric vehicles(EVs). 展开更多
关键词 Vehicle-to-grid(V2G)interaction artificial intelligence collaborative optimization electric vehicles grid scheduling
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Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical“hot”herbs on hypothyroidism 认领 引用
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作者 YangYang Wang Yizhou Rong +3 位作者 Liangce Chen Qi Cui Haixue Kuang Bo Yang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第4期876-878,共3页
That herbs with the"hot"property used to treat"cold"syndromes is a guiding principle of clinical prescription and medication in traditional Chinese medicine(TCM).However,this theory of TCM is still... That herbs with the"hot"property used to treat"cold"syndromes is a guiding principle of clinical prescription and medication in traditional Chinese medicine(TCM).However,this theory of TCM is still in the‘black box'stage,and few in-depth studies have examined the biological mechanisms underpinning the hot properties of herbs. 展开更多
关键词 biological mechanisms hypothalamic lipidomics AMPK hypothyroidism hot herbs traditional chinese medicine tcm howeverthis traditional Chinese medicine energy balancing effect
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A Directional Locomotion Control of Cyborg Locusts for Complex Outdoor Environments 认领 引用
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作者 Xin Huang Tiancheng Li +2 位作者 Kaixuan Sun Meisong Yuan Bo Yang 《Journal of Bionic Engineering》 SCIE EI CSCD 2025年第2期596-607,共12页
The ability of cyborg locusts to achieve directional movement in complex outdoor environments is critical for search and rescue missions.Currently,there is a lack of research on motion control for cyborg locusts in ou... The ability of cyborg locusts to achieve directional movement in complex outdoor environments is critical for search and rescue missions.Currently,there is a lack of research on motion control for cyborg locusts in outdoor settings.In this study,we developed cyborg locusts capable of performing directional locomotion in intricate outdoor environments,including jumping over obstacles,climbing slopes,traversing narrow pipelines,and accurately reaching predetermined targets along specified routes.We designed a miniature electrical backpack(10 mm×10 mm,0.75 g)capable of receiving stimulus parameters(frequency,duty ratio,and stimulation time)via Bluetooth commands from mobile phones.Electrical stimulation of locust sensory organs,such as the antennae and cercus,induced turning and jumping behaviors.Experi-mental testing of locust movement control was conducted under outdoor conditions with a short electrical stimulation interval.Results showed a positive correlation between locust turning angles and electrical stimulation parameters within a specified range,with an average jumping height exceeding 10 cm.Additionally,the success rate of locust turning and jumping behaviors correlated positively with the interval time between electrical stimulations.Adjusting these intervals during forward crawling phases increased the likelihood of the locusts jumping again.In conclusion,this study success-fully achieved directional locomotion control of cyborg locusts outdoors,providing insights and references for advancing search and rescue capabilities. 展开更多
关键词 Cyborg locusts Turning and jumping control Directional locomotion Search and rescue
Second post-Newtonian motion in Simpson–Visser black-bounce spacetime 认领 引用
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作者 Bo Yang Chunhua Jiang Wenbin Lin 《Communications in Theoretical Physics》 SCIE CAS CSCD 2025年第9期72-80,共9页
In this paper,we present the second post-Newtonian solution for the quasi-Keplerian motion of a test particle in the regular Simpson–Visser black-bounce spacetime which has a bounce parameter a.The obtained solution ... In this paper,we present the second post-Newtonian solution for the quasi-Keplerian motion of a test particle in the regular Simpson–Visser black-bounce spacetime which has a bounce parameter a.The obtained solution is formulated in terms of orbital energy,angular momentum,and the bounce parameter of the black hole.We explicitly analyze the leading effects of the bounce parameter which has dimensions of length,on the test particle’s orbit,including the periastron advance and orbital period.Then,we apply this model to the precessing motion of OJ 287 and determine the upper limits of the dimensionless bounce parameter as a/m=3.45±0.01,where m is the mass of the regular black hole.Compared with the bound given by the periastron advance of star S2,our bound on a/m is reduced by one order of magnitude,although our upper limit of a still needs further improvement. 展开更多
关键词 Black holes Regular Simpson-Visser black-bounce spacetime Periastron advance
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Climate physical risks:catalyst or constraint for the convergence of the digital and low-carbon economies? 认领 引用
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作者 Ya Cui Bo Yang 《Data Science and Management》 EI CSCD 2025年第4期500-518,共19页
The digital economy and the low-carbon economy are crucial catalysts of global economic change and sustainable development.This research focuses on China and thoroughly examines the coupling and coordination mechanism... The digital economy and the low-carbon economy are crucial catalysts of global economic change and sustainable development.This research focuses on China and thoroughly examines the coupling and coordination mechanisms between the digital and low-carbon economies.This study employs the coupling coordination degree model to assess the development level of the coupling and coordination between the two economies.It also investigates the influence of climate-related physical threats on their coupled and coordinated development and presents the following findings.First,the integration and synchronized advancement of China's digital and low-carbon economies exhibit a general upward trend,though the average development level remains relatively low,characterized by considerable regional variations.Moreover,the dynamic distribution of coupling and coordination development levels among locations reveals notable disparities.Second,the coupling coordination degree between China's digital and low-carbon economies exhibits distinct spatial correlation,following a“high-high,lowlow”distribution pattern,with transfer channels exhibiting spatial dependence.Third,Tobit model analysis reveals that climate-related physical dangers substantially impede the integration and synchronized advancement of digital and low-carbon economies.The underlying mechanism is the inhibition of green low-carbon technological innovation,with extremely low temperatures exerting the most significant suppressive influence.This suppression varies based on geographic location,data development,and resource endowment. 展开更多
关键词 Digital economy Low-carbon economy Coupling coordination degree model Tobit model Climate physical risks
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Single-cell RNA sequencing of the post-spinal cord injury dorsal root ganglia in cynomolgus monkeys:Elucidation of the cellular immune microenvironment of the central nervous system 认领 引用
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作者 Yiming Ren Bo Li +6 位作者 Bo Yang Baoyou Fan Shenghui Huang Guidong Shi Liang Liu Zhijian Wei Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2506-2513,共8页
Few studies have investigated alterations in the immune cell microenvironment of the dorsal root ganglia following spinal cord injury and whether these modifications facilitate axonal regeneration.In this study,we use... Few studies have investigated alterations in the immune cell microenvironment of the dorsal root ganglia following spinal cord injury and whether these modifications facilitate axonal regeneration.In this study,we used a single-cell RNA sequencing dataset to create a comprehensive profile of the diverse cell types in the dorsal root ganglia and spinal cord of a mid-thoracic contusion injury model in cynomolgus monkeys.Cell communication analysis indicated that specific signaling events among various dorsal root ganglia cell types occur in response to spinal cord injury.Single-cell analysis using dimensionality reduction clustering identified distinct molecular signatures for nine cell types,including macrophage subpopulations,and differential gene expression profiles between dorsal root ganglia cells and spinal cord cells following spinal cord injury.The macrophage subpopulations were categorized into 11 clusters(MC0-MC10)based on differentially expressed genes,with the top 10 genes being ABCA6,RBMS3,EBF1,LAMA4,ANTXR2,LAMA2,SOX5,FOXP2,GHR,and APOD.MC0,MC1,and MC2 constituted the predominant macrophage populations.MC4,MC6,and MC9 were nearly absent in the spinal cord,but exhibited significant increases in the dorsal root ganglia post-spinal cord injury.Notably,these subpopulations possess a strong capacity for regulating axonal regeneration.The developmental progression of dorsal root ganglia macrophages after spinal cord injury was elucidated using cell trajectory and pseudo-time analyses.Genes such as EBF1(MC6 and MC9 marker),RBMS3(MC6 and MC9 marker),and ABCA6(MC6 marker)showed high expression levels in the critical pathways of macrophage function.Through ligand-receptor pair analysis,we determined that the effects of macrophages on microglia are predominantly mediated through interaction pairs(e.g.,SPP1-CD44,LAMC1-CD44,and FN1-CD44),potentially facilitating specific cellular communications within the immune microenvironment.The single-cell RNA sequencing dataset used in this study represents the first comprehensive transcriptional analysis of the dorsal root ganglia after spinal cord injury in cynomolgus monkeys,encompassing nearly all cell types within the dorsal root ganglia region.Using this dataset,we evaluated diverse subtypes of macrophages in the post-spinal cord injury dorsal root ganglia area and examined the signaling pathways that facilitate interactions among immune response-related macrophages in the dorsal root ganglia.Findings from this study provide a theoretical basis for understanding how the immune microenvironment influences the regenerative capacity of dorsal root ganglia neurons after spinal cord injury and offer novel insights into the complex processes underlying the pathobiology of spinal cord injury. 展开更多
关键词 cellular communication cellular microenvironment differentially expressed genes dorsal root ganglia immune cells macrophage microglia neurons single-cell sequence spinal cord injury
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Compact InAs Quantum Dot Multilayers Realizing High-Power Lasers 认领 引用
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作者 Zhi-jiang Chen Bo Yang +5 位作者 Ze-chang Yin Jia Chen Wen-qi Wei Zi-hao Wang Ting Wang Jian-jun Zhang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第4期99-104,共6页
Utilizing quantum dots(QDs)as a gain medium to achieve ultra-high optical output at telecommunication wavelengths remains a persistent goal.In this work,we present an approach to enhance optical gain while maintaining... Utilizing quantum dots(QDs)as a gain medium to achieve ultra-high optical output at telecommunication wavelengths remains a persistent goal.In this work,we present an approach to enhance optical gain while maintaining a compact active region,suitable for high-power QD lasers operating at a wavelength of 1.31µm.By reducing the growth temperature of In As QDs in the latter layers,compact 12-layer QDs with high density and photoluminescence intensity are achieved. 展开更多
关键词 quantum dots gain medium high power lasers quantum dots qds optical gain reducing growth temperature enhance optical gain qd lasers
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The tensile strain effect on multi-coverage structures of hydrogen adsorption at Pt(111)electrocatalyst surfaces:DFT calculation study 认领 引用
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作者 Qibo Deng Rui Huang +5 位作者 Longhui Wang Cuihua An Bo Yang Jun Xu Junsheng Li Ning Hu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第6期182-210,共29页
Understanding the adsorption behavior of hydrogen on catalyst surfaces is critical to a comprehensive analysis of the kinetics of the hydrogen evolution reaction(HER).While strain engineering to enhance single hydroge... Understanding the adsorption behavior of hydrogen on catalyst surfaces is critical to a comprehensive analysis of the kinetics of the hydrogen evolution reaction(HER).While strain engineering to enhance single hydrogen adsorption on catalysts is well-established,the mechanisms governing multiple hydrogen adsorption under strain remain unclear.In this study,we systematically investigate different adsorption structures of multi-coverage hydrogen on the Pt(111)catalyst’s surface by first-principles calculations.We propose two dimensions,“ke”and“kε”,to quantitatively describe the relationship between adsorption energy and d-band center with stress under different coverage levels.The results indicate that the above two values undergo dynamic changes under different coverage levels,proving that there are differences in the effect of stress under different H coverage conditions.Especially under high coverage,stress has a significant enhancement effect on H adsorption.Although the enhancement effect slightly decreases when hydrogen molecules are produced,there is still a significant overall enhancement,effectively suppressing the weakening of the original Pt-H adsorption caused by high coverage.We conducted theoretical verification from the perspectives of changes in adsorption energy and d-band center using these two dimensions,confirming that stress can effectively alter the d-band structure of Pt,optimize its interaction with adsorbed hydrogen,and provide a theoretical basis for further improving the HER performance of Pt catalysts under high current density by applying external stress. 展开更多
关键词 Multi-hydrogen adsorption Electrocapillary coupling Strain engineering First-principles calculation d-band center
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ZmCals12 impacts maize growth and development by regulating symplastic transport 认领 引用
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作者 Ziwen Shi Sheng Zhang +6 位作者 Qing He Xiaoyuan Wang Bo Yang Tao Yu Hongyang Yi Tingzhao Rong Moju Cao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期42-55,共14页
Carbohydrate partitioning from source to sink tissues is essential for plant growth and development.However,in maize(Zea mays L.),the molecular mechanisms by which callose synthase genes regulate this process remain l... Carbohydrate partitioning from source to sink tissues is essential for plant growth and development.However,in maize(Zea mays L.),the molecular mechanisms by which callose synthase genes regulate this process remain largely unexplored.This study demonstrates that mutation of maize callose synthase12(Zm Cals12)results in increased carbohydrate accumulation in photosynthetic leaves but decreased carbohydrate content in sink tissues,leading to plant dwarfing and male sterility.Histochemical β-glucuronidase(GUS)activity assay and m RNA in situ hybridization(ISH)revealed that Zm Cals12 expression mainly occurs in the vascular transport system.Zm Cals12 loss-of-function decreased callose synthase activity and callose deposition in plasmodesmatas(PDs)and surrounding phloem cells(PCs)of the vascular bundle.The drop-and-see(DANS)assay indicated reduced PD permeability in photosynthetic cells and diminished transport competence of leaf veins in Zmcals12 mutants,resulting in decreased symplastic transport.Paraffin section analysis revealed that less-developed vascular cells(VCs)in Zmcals12 mutants likely disrupted sugar transport,contributing to the pleiotropic phenotype.Furthermore,impaired sugar transport inhibited internode development by suppressing auxin(IAA)biosynthesis and signaling in Zmcals12 mutant.These findings elucidate the mechanism by which Zm Cals12-mediated callose deposition and symplastic transport regulate maize growth and development. 展开更多
关键词 maize ZmCals12 plasmodesmata(PD)permeability symplastic transport less-developed vascular cells(VCs) auxin(IAA)biosynthesis and signaling
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Unveiling the safe dose range of the conjugated linolenic acid cis9,trans11,cis15-CLNA from Bifidobacterium breve 认领 引用
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作者 Zihuan Wu Haiqin Chen +2 位作者 Bo Yang Jianxin Zhao Wei Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1745-1756,共12页
Previous studies have demonstrated that cis9,trans11,cis15-CLNA(c9,t11,c15-CLNA),a metabolite of Bifidobacterium breve CCFM683,possesses anti-inflammatory properties in the intestine.However,its safety profile remains... Previous studies have demonstrated that cis9,trans11,cis15-CLNA(c9,t11,c15-CLNA),a metabolite of Bifidobacterium breve CCFM683,possesses anti-inflammatory properties in the intestine.However,its safety profile remains unexplored.This study establishes the safe dose range for c9,t11,c15-CLNA and investigates the potential damage pathways.The results indicate that the maximum safe dose for mice is lower than 625 mg/kg,primarily due to hepatocyte damage.In cellular experiments revealed that an overdose of c9,t11,c15-CLNA activates peroxisome proliferator-activated receptor gamma(PPAR-γ),leading to hepatic lipid accumulation.The addition of the PPAR-γinhibitor partially mitigated this effect.In summary,this study established that the maximum tolerated dose of c9,t11,c15-CLNA in healthy adult C57BL/6N mice is 625 mg/kg.For human application,the estimated safe dose is below 50.62 mg/kg.Additionally,c9,t11,c15-CLNA was found to activate the PPAR-γprotein in the liver,leading to lipid accumulation within hepatic tissue. 展开更多
关键词 cis9 trans11 cis15-CLNA Acute toxicity Subchronic toxicity Peroxisome proliferator-activated receptor gamma
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Infant feces-derived Bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway 认领 引用
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作者 Bowen Li Mengfan Ding +7 位作者 Chen Chi Guoxun Shi Xiaoming Liu Jianxin Zhao Paul Ross Catherine Stanton Wei Chen Bo Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期136-153,共18页
This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia(RC).Twenty-four female Wistar rats were assigned to 3 groups:CON group(normal saline by gavage)... This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia(RC).Twenty-four female Wistar rats were assigned to 3 groups:CON group(normal saline by gavage),CIA group(collagen-induced arthritis(CIA),normal saline by gavage),and CCFM1078 group(CIA,3×109CFU/(rat·day)B.breve CCFM1078 gavage).The results demonstrated that B.breve CCFM1078 not only improved skeletal muscle function in CIA rats,but also modulated the gut microbiota,skeletal muscle metabolism and hormone levels,reduced inflammation in the knee joint and skeletal muscles,decreased activity of the nuclear factor κB(NF-κB)inflammatory signaling pathway,enhanced the insulin receptor substrate 1(IRS1)/phosphatidylinositol 3-kinase/protein kinase(PI3K/Akt)signaling pathway,promoted skeletal muscle differentiation,and maintained skeletal muscle fiber diameter,consequently slowing down the progression of RC.These findings suggested that B.breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC,enhancing overall therapeutic effects. 展开更多
关键词 Bifidobacterium breve Rheumatoid cachexia Skeletal muscle NF-κB pathway IRS1/PI3K/Akt pathway Gut microbiota
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Evolution of multistage dolomitization fluids in the Upper Ediacaran Qigebrak Formation,northern Tarim Basin,China:Effects on reservoir formation 认领 引用
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作者 Pan Tang Xiang-Rong Yang +5 位作者 Feng Guo You-Jun Tang Yuan-Zheng Wang Bo Yang Wen-Yang Wang Dai-Zhao Chen 《Petroleum Science》 SCIE EI CAS CSCD 2026年第5期2452-2466,共15页
The deep-buried dolomites of the UpperEdiacaran Qigebrak Formation in the Tarim Basin possess substantial hydrocarbon potential.Although diageneticprocesses,particularlydolomitization,are recognized as critical for re... The deep-buried dolomites of the UpperEdiacaran Qigebrak Formation in the Tarim Basin possess substantial hydrocarbon potential.Although diageneticprocesses,particularlydolomitization,are recognized as critical for reservoir evolution in this formation,their specific impacts on reservoir quality remain poorly understood.This study utilizes newly acquired petrographic,stable isotope,and radiogenic isotope data,integrated with carbonate U-Pb ages and temperature data,to elucidate the relationship between dolomitization processesand reservoir evolution in the Qigebrak Formation.Seven distinct dolomite phases were identified:dolomicrite(D1),very fine crystalline dolomite(D2),fine crystalline dolomite(D3),fibrous dolomite cement(D4),bladed dolomite cement(D5),fine to medium crystalline dolomite cement(D6),and coarse crystalline saddle dolomite cement(D7).D1 and D2 exhibitδ13C and87Sr/86Sr ratios consistent with coeval Ediacaran seawater,indicating an initial syngenetic dolomitization event in restricted lagoonidal flat environments.This event formed via nearsurface dolomitization driven by the reflux of slightly evaporative seawater.D4 and D5 also precipitated in near-surface settings under seawater dolomitization conditions,but their depletedδ13C andδ18O values with elevated87Sr/86Sr ratios suggest the involvement of meteoric water in the precipitation process.In contrast,most D3 and D6 were formed through burial dolomitization at elevated temperatures.D7 originated from hydrothermaldolomitization at 135150°C,characterized by progressively depletedδ18O ratios with increasing burial depth and the mixing of 87Sr-enriched hydrothermal fluids.Notably,early syngenetic dolomitization preservedprimary poresin the Qigebrak Formation despite long-term burial,whereas later burial and hydrothermal dolomitization primarily adjusted the preexisting pore systems.This study enhances our understanding of multistage dolomitization processes in the Qigebrak Formation and provides insights for future exploration of Precambrian successions. 展开更多
关键词 Multistage dolomitization Deep-buried Upper Ediacaran Reservoir evolution
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Measurement and calculation of neutron transmission spectra through 238U irradiated by a broad-spectrum neutron field 认领 引用
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作者 Hui Sun Xin Zhang +10 位作者 Zhi‑Qiang Chen Rui Han Bo Yang Shakhboz Khasanov Pei‑Yan Zhang Guo‑Yu Tian Bing‑Yan Liu Fu‑Dong Shi Ze‑Kun Zhang Qin Li Peng Luo 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2026年第8期243-251,共9页
The neutron transmission spectrum through a high-purity238 U slab(dimensions:100 mm×100 mm×20 mm)irradiated by a broad-spectrum neutron field was measured at 0°using the time-of-flight(TOF)method.The... The neutron transmission spectrum through a high-purity238 U slab(dimensions:100 mm×100 mm×20 mm)irradiated by a broad-spectrum neutron field was measured at 0°using the time-of-flight(TOF)method.The experiment was carried out at the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics,Chinese Academy of Sciences.Broad-spectrum neutrons were generated by bombarding a tungsten target with 80.5 MeV/u12 C ions.GEANT4 calculations were performed under the same experimental conditions by combining the INCL++,BIC,and BERT physics models with the evaluated nuclear data libraries ENDF/B-VIII.0,JEFF-3.3,and JENDL-4.0.The calculations reproduce the measured spectrum reasonably well over most of the investigated energy range;however,they overestimate the data below 10 MeV and tend to underestimate the measured yield above 70 MeV.The present results provide benchmark information for validating neutron-transport simulations relevant to accelerator-driven systems. 展开更多
关键词 Neutron transmission spectrum 238U Broad-spectrum neutrons GEANT4
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Single-Cell Sequencing Reveals the Heterogeneity of Glioma and Identifies IGFBP2 as A Potential Therapeutic Target 认领 引用
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作者 Jian-Lei Kang Yu-Jie Xu +3 位作者 Qi-Tai Zhao Bing Zhang Xin Xu Bo Yang 《Oncology Research》 SCIE 2026年第7期543-566,共24页
Background:Glioma is among the most malignant brain tumors,and its heterogeneity contributes significantly to treatment failure.Comprehensive profiling of cellular and molecular heterogeneity across different glioma s... Background:Glioma is among the most malignant brain tumors,and its heterogeneity contributes significantly to treatment failure.Comprehensive profiling of cellular and molecular heterogeneity across different glioma stages and recurrence states is crucial for understanding therapeutic resistance and identifying novel targets.Accordingly,this study sought to systematically characterize the cellular and molecular heterogeneity of glioma across different stages and recurrence states using single-cell RNA sequencing,and to identify prognostic subtypes and potential therapeutic targets.Methods:We integrated public single-cell RNA sequencing data from glioma specimens,including lower-grade glioma(LGG),glioblastoma(GBM),and paired primary and recurrent tumors.Using these datasets,we identified distinct cellular subpopulations and their molecular signatures.Based on these glioma cell subpopulations,we reclassified gliomas from The Cancer Genome Atlas(TCGA)database into molecular subtypes and constructed a prognostic model.The functional role of a key candidate gene,insulin-like growth factor binding protein 2(IGFBP2),was validated using in vitro knockdown experiments in mouse and human tumor cells and in vivo therapeutic studies in murine models,including combination therapy with anti-programmed cell death protein 1(anti-PD-1)immune checkpoint blockade.Results:This analysis revealed that T cells in GBM and recurrent samples were predominantly exhausted,characterized by upregulation of PD-1 and T-cell immunoglobulin and mucin-domain containing−3(Tim3),while myeloid cells exhibited an immunosuppressive phenotype with elevated expression of macrophage migration inhibitory factor(MIF)and cluster of differentiation(CD)276.We identified 12 distinct glioma cell subpopulations with varying proliferative and hypoxic signatures.Based on these subpopulations,TCGA gliomas were reclassified into two major subtypes.One subtype,enriched with myeloid-derived suppressor cells(MDSCs)and regulatory T cells(Tregs),was associated with poorer patient prognosis.A prognostic model was successfully established using differentially expressed genes between the subtypes.Furthermore,IGFBP2 was highly expressed in glioma cells,and its expression negatively correlated with T cell infiltration.In vitro knockdown of IGFBP2 downregulated programmed death-ligand 1(PD-L1)expression on tumor cells.In vivo,IGFBP2 knockdown significantly suppressed tumor growth(p<0.01)and extended survival in tumor-bearing mice(p<0.05),and its combination with anti-PD-1 therapy markedly enhanced antitumor efficacy.Conclusions:This study provides deeper insights into the cellular ecosystem and heterogeneity of glioma,linking specific cellular features to patient prognosis.We identify IGFBP2 may play a role in regulating immunosuppressive tumor microenvironment and a potential therapeutic target. 展开更多
关键词 Glioma heterogeneity immunosuppressive tumor microenvironment insulin-like growth factor binding protein 2
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Introduction to the Special Issue on Recent Advances in Signal Processing and Computer Vision 认领 引用
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作者 Bo Yang Chao Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第5期33-36,共4页
Over the past decade, artificial intelligence, particularly deep learning, has fundamentally reshaped the fields of signal processing and computer vision. As mentioned in the introduction to this special issue, we are... Over the past decade, artificial intelligence, particularly deep learning, has fundamentally reshaped the fields of signal processing and computer vision. As mentioned in the introduction to this special issue, we are witnessing a significant paradigm shift. AI has evolved from recognizing the world through classification and detection to simulating it through generative models and synthesis. Most recently, AI has begun to impact the real world through embodied intelligence and robotic interaction. This special issue reflects this trajectory, presenting original research articles, reviews and methodological advances in areas such as multimodal learning, 3D vision, generative modelling, medical image analysis and autonomous systems.The 12 contributions included here reflect the current frontiers of AI, shedding light on the challenges and opportunities involved in bridging the gap between virtual intelligence and physical reality.Reliable and interpretable AI is of paramount importance in medical applications. This issue contains several papers that address various aspects of this challenge, ranging from signal-enhanced diagnosis to surgical perception and 3D reconstruction. 展开更多
关键词 deep learning robotic interaction signal processing computer vision generative models embodied intelligence recognizing world simulating
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