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Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level:what to expect in the Chinese population? 认领 引用 被引量:4
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作者 Jeremy YC Teoh Steffi KK Yuen +6 位作者 James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu 《Asian Journal of Andrology》 SCIE CAS CSCD 2015年第5期821-825,I0010,共5页
We investigated the prostate cancer detection rates upon transrectal ultrasound(TRUS)-guided biopsy in relation to digital rectal examination(DRE)and prostate-specific antigen(PSA),and risk factors of prostate cancer ... We investigated the prostate cancer detection rates upon transrectal ultrasound(TRUS)-guided biopsy in relation to digital rectal examination(DRE)and prostate-specific antigen(PSA),and risk factors of prostate cancer detection in the Chinese population.Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database.The prostate cancer detection rates with reference to DRE finding and PSA level of〈4,4-10,10.1-20,20.1-50 and〉50 ng ml^-1 were investigated.Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection.A total of 2606 Chinese men were included.In patients with normal DRE,the cancer detection rates were 8.6%,13.4%,21.8%,41.7%and 85.2%in patients with PSA〈4,4-10,10.1-20,20.1-50 and〉50 ng ml^-1 respectively.In patients with abnormal DRE,the cancer detection rates were 12.4%,30.2%,52.7%,80.6%and 96.4%in patients with PSA〈4,4-10,10.1-20,20.1-50 and〉50 ng m1-1 respectively.Older age,smaller prostate volume,larger number of biopsy cores,presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses(P〈0.001).Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population.Taking the different risk factors into account,an individualized approach to the decision of TRUS-guided biopsy can be adopted. 展开更多
关键词 Chinese digital rectal examination prostate biopsy prostate cancer prostate-specific antigen
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The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men 认领 引用 被引量:18
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作者 Jeremv YC Teoh Steffi KK Yuen +6 位作者 James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu 《Asian Journal of Andrology》 SCIE CAS CSCD 2017年第1期113-116,共4页
We investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) fro... We investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) from year 2000 to 2013 were included. The receiver operating characteristic (ROC) curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA (P〈 0.001) and 0.823 for PSAD (P〈 0.001). PSA of 4.5 ng ml^-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml^-1cc^-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml^-1 (OR 1.61, 95% CI 1.05-2.45, P = 0.029) and PSAD cut-off at 0.12 ng ml^-1 cc^-1 (OR 6.22, 95% CI 4.20-9.22, P 〈 0.001) were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml^-1 and PSAD of O. 12 ng ml^-1 cc^-1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men. 展开更多
关键词 Chinese prostate cancer transrectal ultrasound-guided prostate biopsy prostate-specific antigen prostate-specific antigen density
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Multiparametric magnetic resonance imaging/transrectal ultrasound fusion prostate biopsy with semi-robotic navigation in the Chinese population: initial results 认领 引用
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作者 Wai Kit Ma Brian SH HO +6 位作者 Andrew SH Lai Ka Cheong Lam Yun Sang Chan Lawrance KC Yip Ada TL Ng James HL Tsu Ming Kwong Yiu 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第1期93-94,共2页
Dear Editor, The current standard 12-core systematic transrectal ultrasound (TRUS)-guided biopsy in prostate cancer diagnosis has the disadvantages of overdetecting indolent tumors, while failing to identify clinica... Dear Editor, The current standard 12-core systematic transrectal ultrasound (TRUS)-guided biopsy in prostate cancer diagnosis has the disadvantages of overdetecting indolent tumors, while failing to identify clinically significant cancers in up to 35%.1 Advances in imaging techniques, notably the multiparametric magnetic resonance imaging (mpMRI), allow clinically significant prostate cancers to be detected with more precise localization) Fusion of MRI and real-time TRUS enables targeted biopsy of suspicious lesions, overcoming human error, and inability of biopsy site tracking in cognitive fusion? Multiple Western series have suggested a higher detection rate, higher specificity, and better risk stratification with fusion biopsy. 展开更多
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