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Efficacy and safety of integrated Chinese and Western medicine in advanced pancreatic cancer:A double-center retrospective cohort study 认领 引用
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作者 Ying-Rui Wang Jin-Qiu Wang +7 位作者 Xue-Jiao Chen Yu Yan Peng-Fei Jiao Yu Zhang Meng-Yi Li Wei Wang Tian-Yu Fan Chao-Feng Zhou 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期79-88,共10页
BACKGROUND Advanced pancreatic cancer(PC)is associated with a poor prognosis.The integration of Chinese and Western medicine(ICWM)has shown promising clinical efficacy.Nonetheless,the existing body of research assessi... BACKGROUND Advanced pancreatic cancer(PC)is associated with a poor prognosis.The integration of Chinese and Western medicine(ICWM)has shown promising clinical efficacy.Nonetheless,the existing body of research assessing the efficacy and safety of this integrative approach is limited,hindering the provision of robust evidence-based support for clinical decision-making.AIM To assess the short-term and long-term efficacy and safety of ICWM compared with Western medicine(WM)as a standalone treatment for advanced PC.METHODS We enrolled 136 patients with advanced PC admitted to Henan Provincial Hospital of Traditional Chinese Medicine and Henan Provincial People’s Hospital from 2019 to 2024.Patients were randomly assigned to the ICWM or WM group(n=66 or n=70,respectively)according to treatment modality.The long-term efficacy was evaluated using survival analyses.Short-term efficacy was assessed by analyzing the tumor response,serum tumor markers,and immune function before and after treatment.Treatment safety was assessed by monitoring bone marrow suppression and hepatic and renal function impairment.RESULTS The median overall survival was 12.91 months and 10.64 months in the ICWM and WM groups,while the median progression-free survival was 5.12 months and 3.55 months,respectively.The disease control rate was significantly higher in the ICWM group than that in the the WM group,while the myelosuppression was significantly milder.The serum tumor markers carbohydrate antigen(CA)19-9 and CA125 showed a significant downward trend before and after treatment in the ICWM group,whereas only CA19-9 showed a significant decrease in the WM group.Post-treatment,both groups showed an upward trend in natural killer cells and CD3+,CD4+,and CD4+/CD8+lymphocytes compared with pre-treatment,with the ICWM group exhibiting a more pronounced increase.The two groups showed no significant differences in hepatic and renal function impairment.CONCLUSION ICWM extended survival in patients with advanced PC,improved long-term efficacy,controlled local lesions,reduced serum tumor markers,enhanced immune function,and improved short-term outcomes,with a favorable safety profile. 展开更多
关键词 Advanced pancreatic cancer Integrated Chinese and Western medicine Retrospective cohort study Survival duration Short-term outcomes Long-term outcomes Safety
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Radiofrequency ablation of liver metastases in a patient with pancreatic cancer and long-term survival:A case report 认领 引用
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作者 Jin-Peng Yong Xiao-Yan Mu +5 位作者 Chao-Feng Zhou Ke-Ke Zhang Jie-Qiong Gao Zhi-Zhong Guo Shi-Fan Zhou Zhen Ma 《World Journal of Clinical Cases》 2025年第20期27-34,共8页
BACKGROUND According to the GLOBCAN2022 database,pancreatic cancer has become the 6th leading cause of cancer-related death worldwide.The latest statistics suggest that the incidence of pancreatic cancer is increasing... BACKGROUND According to the GLOBCAN2022 database,pancreatic cancer has become the 6th leading cause of cancer-related death worldwide.The latest statistics suggest that the incidence of pancreatic cancer is increasing at a rate of 0.5%to 1.0%per year,and it is expected to become the 2nd leading cause of tumor-related deaths in the United States by 2030.More than 50%of pancreatic cancer patients have already developed distant metastases at the time of diagnosis,with the liver being the most common site.Patients with pancreatic cancer with liver metastasis(PCLM)have a worse prognosis than those with locally progressed pancreatic cancer,with a median survival of less than six months.Therefore,the outcome of liver metastases is often a vital determinant of the prognosis of patients with PCLM.There are few successful cases of localized treatment for PCLM patients.Our department recently performed local radiofrequency ablation(RFA)treatment for a PCLM patient through an evidence-based medicine approach,with remarkable therapeutic effects.CASE SUMMARY The patient was admitted to the hospital on May 03,2018,3 weeks after pancreatic cancer surgery.In October 2017,the patient presented with lower back pain.No abnormalities were detected via computed tomography(CT),colonoscopy,or gastroscopy.However,on March 18,2018,the patient was investigated in a foreign hospital via CT,which suggested occupational lesions in the descending part of the duodenum,and magnetic resonance imaging suggested pancreatic occupancy.He was considered to be suffering from pancreatic cancer.He underwent laparoscopic-assisted pancreatic+duodenum+superior mesenteric vein partial resection and reconstruction under general anesthesia on March 26,2018 at The Affiliated Hospital of Xuzhou Medical University.The pancreas and duodenum were partially resected.Postoperative pathology showed adenocarcinoma of the pancreas(moderately differentiated),partly mucinous carcinoma,invading the mucosal layer of the duodenum;the tumor size was 4.5 cm×4 cm×4 cm.There was no apparent nerve or vascular invasion.There was no cancer or involvement of the pancreas section or expected hepatic duct margins.There was no cancer involvement in the gastric and duodenal sections.There was no cancer metastasis to the peripheral lymph nodes of the pancreas(0/9).No metastasis to the gastric lesser curvature or more significant curvature lymph nodes(0/1,0/5)was detected,and the peri-intestinal lymph nodes showed no cancer metastasis(0/4).Although the gallbladder showed signs of chronic cholecystitis,there was no cancer involvement,and the lymph nodes in Groups 12 and 13 also showed no cancer metastasis(0/6,0/1).His postoperative recovery was acceptable.CT was performed on May 2018 at our hospital and found the following:(1)Double lung bronchial vascular bundles slightly heavier than normal;(2)Postoperative changes in the pancreas and a retention tube shadow in front of the head of the pancreas;(3)Small cysts in the right lobe of the liver;(4)Abdominopelvic effusion;and(5)Para splenic enlargement.pTNM stage:PT3N0M0.The patient was in the second stage of postoperative pancreatic cancer,with a potential risk of recurrence considering the patient's postoperative body quality deviation.The patient was unable to tolerate the standard multidrug combination and underwent six cycles of single-agent gemcitabine chemotherapy from May 10,2018 to August 31,2018(the specific drug dosage was 1.4 g/d1/d8 gemcitabine injection,which was repeated every 21 days).Efficacy was determined to be stable disease after 2,4,and 6 cycles.The side effects during treatment were tolerable.CONCLUSION This case suggests that RFA can serve as a viable local treatment modality for selected patients with PCLM,offering a chance for long-term survival.Such localized interventions,when carefully tailored,may complement systemic therapies in controlling metastatic pancreatic cancer. 展开更多
关键词 Radiofrequency ablation Pancreatic cancer Liver metastasis Case report
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