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Perspectives on additive manufacturing for warhead applications 认领 引用 被引量：3
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作者 Hao Xue Qiang Zhou +1 位作者 Chuan Xiao Guangyan Huang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第1期225-251,共27页
According to different damage modes,warheads are roughly divided into three types:fragmentation warheads,shaped charge warheads,and penetrating warheads.Due to limitations in material and structural manufacturing,trad... According to different damage modes,warheads are roughly divided into three types:fragmentation warheads,shaped charge warheads,and penetrating warheads.Due to limitations in material and structural manufacturing,traditional manufacturing methods make it difficult to fully utilize the damage ability of the warhead.Additive manufacturing(AM)technology can fabricate complex structures,with classified materials composition and customized components,while achieving low cost,high accuracy,and rapid production of the parts.The maturity of AM technology has brought about a new round of revolution in the field of warheads.In this paper,we first review the principles,classifications,and characteristics of different AM technologies.The development trends of AM technologies are pointed out,including multi-material AM technology,hybrid AM technology,and smart AM technology.From our survey,PBF,DED,and EBM technologies are mainly used to manufacture warhead damage elements.FDM and DIW technologies are mainly used to manufacture warhead charges.Then,the research on the application of AM technology in three types of warhead and warhead charges was reviewed and the existing problems and progress of AM technologies in each warhead were analyzed.Finally,we summarized the typical applications and look forward to the application prospects of AM technology in the field of warheads. 展开更多
关键词 Additive manufacturing Fragmentation warhead Shaped charge warhead Penetrating warhead Warhead charge
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Research on multi-scale simulation and dynamic verification of high dynamic MEMS components in additive manufacturing 认领 引用 被引量：1
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作者 Sining Lv Hengzhen Feng +2 位作者 Wenzhong Lou Chuan Xiao Shiyi Li 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第5期275-291,共17页
Metal Additive Manufacturing(MAM) technology has become an important means of rapid prototyping precision manufacturing of special high dynamic heterogeneous complex parts. In response to the micromechanical defects s... Metal Additive Manufacturing(MAM) technology has become an important means of rapid prototyping precision manufacturing of special high dynamic heterogeneous complex parts. In response to the micromechanical defects such as porosity issues, significant deformation, surface cracks, and challenging control of surface morphology encountered during the selective laser melting(SLM) additive manufacturing(AM) process of specialized Micro Electromechanical System(MEMS) components, multiparameter optimization and micro powder melt pool/macro-scale mechanical properties control simulation of specialized components are conducted. The optimal parameters obtained through highprecision preparation and machining of components and static/high dynamic verification are: laser power of 110 W, laser speed of 600 mm/s, laser diameter of 75 μm, and scanning spacing of 50 μm. The density of the subordinate components under this reference can reach 99.15%, the surface hardness can reach 51.9 HRA, the yield strength can reach 550 MPa, the maximum machining error of the components is 4.73%, and the average surface roughness is 0.45 μm. Through dynamic hammering and high dynamic firing verification, SLM components meet the requirements for overload resistance. The results have proven that MEM technology can provide a new means for the processing of MEMS components applied in high dynamic environments. The parameters obtained in the conclusion can provide a design basis for the additive preparation of MEMS components. 展开更多
关键词 Additive manufacturing High dynamic MEMS components Multiscale control Process optimization High dynamic verification
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Four-inch high quality crack-free AlN layer grown on a hightemperature annealed AlN template by MOCVD 认领 引用 被引量：7
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作者 Shangfeng Liu Ye Yuan +13 位作者 Shanshan Sheng Tao Wang Jin Zhang Lijie Huang Xiaohu Zhang Junjie Kang Wei Luo Yongde Li Houjin Wang Weiyun Wang Chuan Xiao Yaoping Liu Qi Wang Xinqiang Wang 《Journal of Semiconductors》 EI CAS CSCD 2021年第12期57-61,共5页
In this work,based on physical vapor deposition and high-temperature annealing(HTA),the 4-inch crack-free high-quality AlN template is initialized.Benefiting from the crystal recrystallization during the HTA process,t... In this work,based on physical vapor deposition and high-temperature annealing(HTA),the 4-inch crack-free high-quality AlN template is initialized.Benefiting from the crystal recrystallization during the HTA process,the FWHMs of X-ray rocking curves for(002)and(102)planes are encouragingly decreased to 62 and 282 arcsec,respectively.On such an AlN template,an ultra-thin AlN with a thickness of~700 nm grown by MOCVD shows good quality,thus avoiding the epitaxial lateral over-growth(ELOG)process in which 3-4μm AlN is essential to obtain the flat surface and high crystalline quality.The 4-inch scaled wafer provides an avenue to match UVC-LED with the fabrication process of traditional GaN-based blue LED,therefore significantly improving yields and decreasing cost. 展开更多
关键词 AlN high temperature annealing MOCVD
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Cocrystallisation of high-energy oxidant ammonium dinitramide with triaminoguanidine nitrate for reduced hygroscopicity 认领 引用 被引量：1
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作者 Shuai Zheng Yinglei Wang +4 位作者 Dongdong Hu Zhiyong Zhou Chuan Xiao Shichao Tian Zhongqi Ren 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第10期249-258,共10页
In this work,we utilize a cocrystallization technique to solve the problem of high hygroscopicity of the high-energy oxidant ammonium dinitramide(ADN).For this purpose,a non-hygroscopic oxidant,triaminoguanidine nitra... In this work,we utilize a cocrystallization technique to solve the problem of high hygroscopicity of the high-energy oxidant ammonium dinitramide(ADN).For this purpose,a non-hygroscopic oxidant,triaminoguanidine nitrate(TAGN),is selected as the cocrystallization ligand.The ADN/TAGN system is simulated by using Material Studio 5.5 software,and the DFT of ADN and TAGN molecules are calculated by Gaussian09 software.The most stable molar ratio of the ADN/TAGN cocrystallization is determined to be 1:1,and the hydrogen bonding between the H atom of ADN and the O atom in the TAGN is the driving force for the formation of cocrystals in this system.Moreover,the electrostatic potential interaction pairing energy difference(ΔEpair)<0 kJ·mol-1(-12.71 kJ·mol-1)for nADN:nTAGN=1:1 again indicates cocrystallization at this molar ratio.The crystal structure and crystal morphology is predicted.And the hygroscopicity of ADN/TAGN cocrystal at 20℃and 40%relative humidity is calculated to be only 0.45%.The mechanism of hygroscopicity is investigated by examining the roughness of each crystal surface.Overall,the more hygroscopic it is in terms of surface roughness,with the roughest crystal surface(012)having a hygroscopicity of 1.78,which corresponds to a saturated hygroscopicity of 0.61%.The results show that the(001)crystal surface has the smallest band gap(1.06 eV)and the largest sensitivity.Finally,the oxygen equilibrium value for the ADN/TAGN system is calculated to be-8.2%. 展开更多
关键词 Ammonium dinitramide Triaminoguanidine nitrate Cocrystallization Hygroscopicity
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Research on the quasi-isentropic driving model of aluminized explosives in the detonation wave propagation direction 认领 引用
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作者 Hongfu Wang Yan Liu +5 位作者 Fan Bai Chao He Yingliang Xu Qiang Zhou Chuan Xiao Fenglei Huang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2024年第2期596-618,共23页
Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive f... Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive formulations when driving metal flyer plates in the denotation wave propagation direction.The research results showed that the formulations with 43 μm aluminum(Al) powder particles(The particle sizes of Al powder were in the range of 2~43 μm) exhibited the optimal performance in driving flyer plates along the denotation wave propagation direction. Compared to the formulations with Al powder 13 μm, the formulations with Al powder 2 μm delivered better performance in accelerating metal flyer plates in the early stage, which, however, turned to be poor in the later stage. The CL-20-based explosives containing 25% Al far under-performed those containing 15% Al. Based on the proposed quasi-isentropic hypothesis, relevant isentropy theories, and the functional relationship between detonation parameters and entropy as well as Al reaction degree, the characteristic lines of aluminized explosives in accelerating flyer plates were theoretically studied, a quasi-isentropic theoretical model for the aluminized explosive driving the flyer plate was built and the calculation methods for the variations of flyer plate velocity, Al reaction degree, and detonation product parameters with time and axial positions were developed. The theoretical model built is verified by the experimental results of the CL-20-based aluminized explosive driving flyer plate. It was found that the model built could accurately calculate the variations of flyer plate velocity and Al reaction degree over time. In addition, how physical parameters including detonation product pressure and temperature varied with time and axial positions was identified. The action time of the positive pressure after the detonation of aluminized explosives was found prolonged and the downtrend of the temperature was slowed down and even reversed to a slight rise due to the aftereffect reaction between the Al powder and the detonation products. 展开更多
关键词 Aluminized explosive Flyer plate experiment Quasi-isentropic theoretical model Al reaction Driving characteristics
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Fracture behavior and mechanism of highly fragmented steel cylindrical shell under explosive loading 认领 引用 被引量：5
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作者 Kang Wang Peng Chen +5 位作者 Xingyun Sun Yufeng Liu Jiayu Meng Xiaoyuan Li Xiongwei Zheng Chuan Xiao 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2024年第6期122-132,共11页
An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of th... An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments formed.This study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery experiments.Compared with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution model.The fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high fragmentation.On the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell fragmentation.Although the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical assessment.These results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation. 展开更多
关键词 Projectile fragmentation Fragment mass distribution Fracture mode Metallographic structure Damage power
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Laparoscopic treatment of bilateral duplex kidney and ectopic ureter: A case report 认领 引用 被引量：4
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作者 Shu-Bin Wang Li Wan +6 位作者 Yong Wang Zheng-Jin Yi Chuan Xiao Jing-Zhao Cao Xiang-Yu Liu Rui-Peng Tang Yun Luo 《World Journal of Clinical Cases》 SCIE 2022年第23期8344-8351,共8页
BACKGROUND Duplication of the renal pelvis is a common congenital malformation of the urinary system.About one-third of cases are complete unilateral duplication of the renal pelvis,while bilateral duplication is extr... BACKGROUND Duplication of the renal pelvis is a common congenital malformation of the urinary system.About one-third of cases are complete unilateral duplication of the renal pelvis,while bilateral duplication is extremely rare.Herein,we described a single case of bilateral renal duplication with double ureteral orifice ectopic vaginal fistula treated with laparoscopy.CASE SUMMARY A 6-year-old girl suffering from long-term vaginal leakage was admitted on June 10,2018.She was diagnosed with complete duplication of both kidneys and ureters and ectopic opening of both ureters combined with ureterovaginal fistula.The patient received laparoscopic ectopic ureteral bladder replantation and was followed up for 2 years.No renal function damage and vaginal leakage were found.CONCLUSION Laparoscopic bladder-ureter reimplantation could effectively determine the location and number of ectopic ureters by imaging and cystoscopy. 展开更多
关键词 Complete duplex kidney Ureteral orifice ectopic Vaginal fistula Laparoscopic Rare urinary malformation Case report
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Studies on ammonium dinitramide and 3,4-diaminofurazan cocrystal for tuning the hygroscopicity 认领 引用 被引量：1
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作者 Dongdong Hu Yinglei Wang +3 位作者 Chuan Xiao Yifei Hu Zhiyong Zhou Zhongqi Ren 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第9期157-164,共8页
Ammonium dinitramide(ADN)is a promising oxidizer with high energy characteristic,which is a relatively new environmentally friendly oxidizer without halogens and carbon elements.However,ADN has high hygroscopicity whe... Ammonium dinitramide(ADN)is a promising oxidizer with high energy characteristic,which is a relatively new environmentally friendly oxidizer without halogens and carbon elements.However,ADN has high hygroscopicity when exposed to high humidity air,restricting its applications on the solid propellants.In this paper,a novel energetic cocrystal composed of ammonium dinitramide and 3,4-diaminofurazan(DAF)was proposed and successfully synthesized by antisolvent crystallization method,and the properties of the cocrystal were systematically investigated by analytical characterization and theoretical simulation calculations.The formation of the cocrystal was confirmed by powder X-ray diffraction,differential scanning calorimetry,scanning electron microscopy,infrared spectroscopy and Raman spectroscopy,indicating that the synthesized product was a cocrystal.Through theoretical studies,the ADN/DAF cocrystal structure was predicted,and the powder X-ray diffraction,morphology,water sorption capacity of ADN/DAF cocrystal were calculated,which was consistent with experimental phenomena.The results showed that newly prepared cocrystal of ADN/DAF had lower hygroscopicity compared to pure ADN,and the water sorption capacity was reduced from 15.35%to 7.90%.This may be due to the formation of N-H…O medium-strength hydrogen bonds between the ammonium ion of ADN and the O atom of DAF in the cocrystal,which prevents the binding of water molecules in the air and ammonium ions and reduces the probability of ADN binding to water molecules,leading to the reduction of cocrystal hygroscopicity.The newly prepared energetic cocrystal can provide theoretical and technical guidance for the study of the anti-hygroscopicity of ADN and advance the practical application of ADN. 展开更多
关键词 Ammonium dinitramide 3,4-Diaminofurazan Hygroscopicity Cocrystallization Adsorption Kinetics
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Coupling Vibration of Simply-Supported Damping Beam Carrying a Moving Mass 认领 引用 被引量：1
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作者 Jingjing Hu Weipeng Hu +1 位作者 Chuan Xiao Zichen Deng 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2022年第6期972-978,共7页
The coupling dynamic problems,such as the vehicle-bridge interaction problem,are difficult to be analyzed.In this paper,the generalized multi-symplectic approach is employed to investigate the coupling dynamic behavio... The coupling dynamic problems,such as the vehicle-bridge interaction problem,are difficult to be analyzed.In this paper,the generalized multi-symplectic approach is employed to investigate the coupling dynamic behaviors in the vehicle-bridge interaction system.A simply-supported damping beam model carrying a moving mass is considered and the generalized multi-symplectic form with the dynamical symmetry breaking factors is deduced firstly.And then,Preissmann’s scheme is employed to discretize the generalized multi-symplectic form,and the discrete structure-preserving condition for the numerical scheme is presented.According to the discrete structure-preserving condition,the permitted moving speed of the mass with different damping factors and different time step lengths is obtained to ensure the structure-preserving properties of the numerical scheme.Finally,the effects of the damping factor of the beam and the moving speed of the mass on the vibration of the beam are investigated by Preissmann’s scheme.The main contribution of this work is to provide a structure-preserving analysis approach for the vehicle-bridge interaction problem. 展开更多
关键词 Vehicle-bridge interaction Dynamical symmetry breaking Generalized multi-symplectic Hamiltonian Moving mass
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Optimization of technical measures for improving high-temperature performance of asphalt-rubber mixture 认领 引用 被引量：2
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作者 Chuan Xiao Tianqing Ling Yanjun Qiu 《Journal of Modern Transportation》 2013年第4期273-280,共8页
Asphalt-rubber pavements often become dam-aged in high-temperature regions and appear rutted or wavy, and experience slippage. To improve the high-temperature performance of the asphalt-rubber mixture, technical measu... Asphalt-rubber pavements often become dam-aged in high-temperature regions and appear rutted or wavy, and experience slippage. To improve the high-temperature performance of the asphalt-rubber mixture, technical measurements, such as, the optimal adjustment of gradation, technique of composite modification, and control of compaction were investigated. An optimal adjustment of aggregate gradation based on stone matrix asphalt improves the high-temperature stability of the asphaltrubber mixture significantly. Through composite modifi- cation, the effect of asphalt-rubber modification was enhanced, and the dynamic stability and relative defor- mation indices of the asphalt-rubber mixture were improved significantly. Furthermore, compaction parame- ters had a significant influence on the high-temperature stability of the asphalt-rubber mixture. The rolling times for compacting the asphalt-rubber mixture should be controlled to within 18-20 round-trips at a molding temperature at 180℃; if the rolling time is a 12 round-trip, the compaction temperature of the asphalt-rubber mixture should be controlled between 180 and 190℃. 展开更多
关键词 Road engineering test Asphalt-rubber mixture performance Optimization Laboratory High-temperature
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Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis 认领 引用 被引量：1
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作者 Yaqi Yuan Peng Jiang +4 位作者 Chuan Xiao Jiapeng Lei Bo Cheng Hankun Hu Wei Li 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2026年第1期458-469,共12页
Psoriasis is a prevalent chronic inflammatory skin disorder,characterized by epidermal thickening and an inflammatory hypoxic microenvironment,which significantly hinder drug penetration through the thickened skin and... Psoriasis is a prevalent chronic inflammatory skin disorder,characterized by epidermal thickening and an inflammatory hypoxic microenvironment,which significantly hinder drug penetration through the thickened skin and limit the efficacy of photodynamic therapy(PDT).Here,we introduce a dual-section microneedle(MN)patch(termed S-PTP MN patch)to enhance the therapeutic efficacy of psoriasis treatment.The needle section contains PTP nanoparticles(NPs)loaded with triamcinolone acetonide(TA)and coated with a reactive oxygen species(ROS)-responsive layer,while the base section of the patch encapsulates sodium percarbonate(SPC)particles that serve as oxygen generators to facilitate deep penetration of the PTP NPs into inflammatory sites and improve PDT efficacy.Moreover,the PTP NPs enable sustained release of TA drug over 6 days,demonstrating potent anti-inflammatory activity.In an imiquimod-induced psoriatic mouse model,a single application of the S-PTP MN patch demonstrated superior therapeutic efficacy compared to the conventional topical TA cream,with significantly alleviated clinical symptoms,reduced epidermal thickness,and lowered inflammatory cytokine levels,highlighting the potential of the S-PTP MN patch as a clinically translatable strategy for effective psoriasis therapy. 展开更多
关键词 Psoriasis Microneedle Responsive release Drug delivery Oxygen Reactive oxygen species Sustained release Triamcinolone acetonide
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Study on Thermodynamics and Kinetics for the Reaction of Magnesium Diboride and Water by Microcalorimetry 认领 引用
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作者 Fengqi Zhao Xiaoling Xing +5 位作者 Chuan Xiao Rongzu Hu Liang Xue Hongxu Gao Libai Xiao Ting An 《American Journal of Analytical Chemistry》 CAS 2011年第2期270-275,共6页
An exothermic reaction between MgB2 and water was observed in our laboratory at high temperature, although no obvious reaction occurred at room temperature. The reaction process of MgB2 and water was therefore studied... An exothermic reaction between MgB2 and water was observed in our laboratory at high temperature, although no obvious reaction occurred at room temperature. The reaction process of MgB2 and water was therefore studied by using microcalorimetry. The results showed that the reaction enthalpies of MgB2 with water and the formation enthalpies of MgB2 at T = (323.15, 328.15, 333.15 and 338.15) K are (–313.15, –317.85, –322.09, –329.27) kJ?mol–1, and (–238.96, –237.73, –236.50, –234.30) kJ●mol–1, respectively. The standard enthalpy of formation and standard molar heat capacity of MgB2 obtained by extrapolation method are –245.11 kJ●mol–1 and 246 J●mol–1●K–1, respectively. The values of activation energy E, pre-exponential factor A and the reaction order for the reaction of MgB2 and water over the temperature range from 323.15 K to 338.15 K are 50.80 kJ●mol–1, 104.78 s–1 and about 1.346, respectively. The positive values of ΔG≠ and ΔH≠ and negative value of ΔS≠ indicate that the reaction can take place easily above 314.45 K. 展开更多
关键词 Magnesium Diboride Water Microcalorimetry Thermodynamics Kinetics
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Early Identification and Diagnosis of Adrenal Crisis after Retroperitoneal Laparoscopic Unilateral Adrenalectomy 认领 引用
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作者 Li Wan Yong Wang +6 位作者 Shubin Wang Jingzhao Cao Zhengjin Yi Xiangyu Liu Chuan Xiao Yun Luo Xupan Wei 《Journal of Endocrinology Research》 CAS 2020年第2期22-26,共5页
The occurrence of adrenal crisis after retroperitoneal laparoscopic unilateral adrenalectomy is usually concealed.If not timely diagnosis and treatment,it may cause shock,and even lead to death.It is very difficult to... The occurrence of adrenal crisis after retroperitoneal laparoscopic unilateral adrenalectomy is usually concealed.If not timely diagnosis and treatment,it may cause shock,and even lead to death.It is very difficult to distinguish the clinical manifestations of adrenal crisis from nausea,vomiting,fatigue,gas separation from the lower diaphragm,abdominal pain,hypotension,hypertension,fever and hypothermia after operation.This makes it very difficult to identify and diagnose adrenal crisis early.This article mainly discusses the early recognition,diagnosis and treatment of adrenal crisis after unilateral adrenalectomy by retroperitoneoscope. 展开更多
关键词 Retroperitoneoscope Unilateral adrenalectomy Adrenal crisis Adrenal insufficiency Shock Early recognition
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Correlation between Prostatic Calculi and Benign Prostatic Hyperplasia 认领 引用
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作者 Ruipeng Tang Chuan Xiao 《Journal of Endocrinology Research》 CAS 2020年第1期44-46,共3页
Prostatic calculus is a common disease of the urinary system,Prostate stones are more common in middle-aged and elderly men,With the development of ultrasonic diagnosis,more and more patients with prostate stone were ... Prostatic calculus is a common disease of the urinary system,Prostate stones are more common in middle-aged and elderly men,With the development of ultrasonic diagnosis,more and more patients with prostate stone were found in physical examination,According to research shows,The vast majority of patients with benign prostatic hyperplasia in the pathogenesis of examination was found to have prostate stones,but so far the correlation between prostate stones and benign prostatic hyperplasia is still not very clear,Benign prostatic hyperplasia is an important factor affecting the physical and mental health and quality of life of the elderly male,With an increasing trend of population aging in China more quickly,this problem is more and more outstanding,but also allows us to further study the relationship between prostate stones and benign prostatic hyperplasia. 展开更多
关键词 Prostatic calculus Benign prostatic hyperplasia Correlation
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Generalization of negative memories drives the development of psychological distress-related behaviors 认领 引用
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作者 Xin Cheng Yubo Hu +14 位作者 Yan Zhao Panwu Zhao Jiale Chen Xiaomeng Bai Yi Chen Deshan Kong Chuan Xiao Youhua Xu Shuyu Zheng Yuena Zheng Yumeng Wang Hu Zhao Yanni Zeng Wei-Jye Lin Xiaojing Ye 《The Innovation》 EI 2026年第7期48-62,共15页
Individuals with depression and anxiety often exhibit intensified and overgeneralized negative memories.However,the causal contribution of memory features,especially the relative roles of memory strengthening versus g... Individuals with depression and anxiety often exhibit intensified and overgeneralized negative memories.However,the causal contribution of memory features,especially the relative roles of memory strengthening versus generalization in shaping subsequent affective disturbances,remains poorly understood.Here,we developed behavioral paradigms to dissociate memory generalization from strengthening and found that negative experiences leading to memory overgeneralization,but not those enhancing memory strength alone,triggered stress-related behaviors in mice.We identified the projection from medial prefrontal cortex(mPFC)to the bed nucleus of the stria terminalis(BNST)as a key circuit linking generalized memory to stress-related phenotypes.Single-cell calcium imaging revealed a significant overlap between the BNST-projecting mPFC(mPFCBNST)neuronal ensemble encoding stress-related behaviors and that encoding generalized memory,but not memory strength.Circuit-specific transcriptomic profiling,chromophore-assisted light inactivation,and short hairpin RNA-mediated gene knockdown further demonstrated that actin cytoskeleton remodeling within the mPFCBNSTneurons,a molecular event underlying the formation of memory generalization,is essential for the emergence of stress-related behaviors.Collectively,these findings identify the generalization of negative memories as a principal driver of stress-related behaviors.More broadly,they provide mechanistic insight into how overgeneralized negative memories,a cognitive feature commonly observed in psychological disorders,may contribute to vulnerability to psychological distress,thereby offering a conceptual framework relevant to early identification and intervention in affective disorders. 展开更多
关键词 negative experiences Bed Nucleus Stria Terminalis behavioral paradigms Negative Memories Medial Prefrontal Cortex Memory Generalization Cognitive Feature Stress Related Behaviors
Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer’s disease 认领 引用 被引量：6
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作者 Min Zhang Zhan Zhang +10 位作者 Honghong Li Yuting Xia Mengdan Xing Chuan Xiao Wenbao Cai Lulu Bu Yi Li Tae-Eun Park Yamei Tang Xiaojing Ye Wei-Jye Lin 《Translational Neurodegeneration》 SCIE CSCD 2024年第1期1107-1129,共23页
Background Alzheimer’s disease(AD)is a neurodegenerative disorder and the predominant type of dementia worldwide.It is characterized by the progressive and irreversible decline of cognitive functions.In addition to t... Background Alzheimer’s disease(AD)is a neurodegenerative disorder and the predominant type of dementia worldwide.It is characterized by the progressive and irreversible decline of cognitive functions.In addition to the pathological beta-amyloid(Aβ)deposition,glial activation,and neuronal injury in the postmortem brains of AD patients,increasing evidence suggests that the often overlooked vascular dysfunction is an important early event in AD pathophysiology.Vascular endothelial growth factor(VEGF)plays a critical role in regulating physiological functions and pathological changes in blood vessels,but whether VEGF is involved in the early stage of vascular pathology in AD remains unclear.Methods We used an antiangiogenic agent for clinical cancer treatment,the humanized monoclonal anti-VEGF antibody bevacizumab,to block VEGF binding to its receptors in the 5×FAD mouse model at an early age.After treatment,memory performance was evaluated by a novel object recognition test,and cerebral vascular permeability and perfusion were examined by an Evans blue assay and blood flow scanning imaging analysis.Immunofluorescence staining was used to measure glial activation and Aβdeposits.VEGF and its receptors were analyzed by enzyme-linked immunosorbent assay and immunoblotting.RNA sequencing was performed to elucidate bevacizumab-associated transcriptional signatures in the hippocampus of 5×FAD mice.Results Bevacizumab treatment administered from 4 months of age dramatically improved cerebrovascular functions,reduced glial activation,and restored long-term memory in both sexes of 5×FAD mice.Notably,a sex-specific change in different VEGF receptors was identified in the cortex and hippocampus of 5×FAD mice.Soluble VEGFR1 was decreased in female mice,while full-length VEGFR2 was increased in male mice.Bevacizumab treatment reversed the altered expression of receptors to be comparable to the level in the wild-type mice.Gene Set Enrichment Analysis of transcriptomic changes revealed that bevacizumab effectively reversed the changes in the gene sets associated with blood-brain barrier integrity and vascular smooth muscle contraction in 5×FAD mice.Conclusions Our study demonstrated the mechanistic roles of VEGF at the early stage of amyloidopathy and the protective effects of bevacizumab on cerebrovascular function and memory performance in 5×FAD mice.These findings also suggest the therapeutic potential of bevacizumab for the early intervention of AD. 展开更多
关键词 Alzheimer’s disease Bevacizumab Vascular endothelial growth factor Cerebrovascular function
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A facile route to synthesize cubic gauche polymeric nitrogen 认领 引用
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作者 Runteng Chen Jun Zhang +8 位作者 Zelong Wang Ke Lu Yi Peng Jianfa Zhao Xiaodong Liu Shaomin Feng Ruibin Liu Chuan Xiao Changqing Jin 《Science Bulletin》 SCIE EI CAS CSCD 2024年第24期3812-3814,共3页
The polymerized nitrogen material with single bonds is considered one of the candidates for storing huge chemical energy due to the significant energy difference between triply bonded di-nitrogen and singly bonded nit... The polymerized nitrogen material with single bonds is considered one of the candidates for storing huge chemical energy due to the significant energy difference between triply bonded di-nitrogen and singly bonded nitrogen[1].It was anticipated that the greatest utility of fully single-bonded nitrogen would yield a tenfold improvement in detonation pressure over HMX(one of the more powerful high explosives)[2]and therefore polymerized nitrogen is of great interest to physical sciences.It was predicted in 1985 that molecule nitrogen would polymerize to atomic solid at high pressure[3]. 展开更多
关键词 bonded polymer cubic
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FPGA-based edge computing: Task modeling for cloud-edge collaboration 认领 引用
18
作者 Chuan Xiao Chun Zhao 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2022年第2期148-167,共20页
With the development of the Internet of Things and devices continuing to scale,using cloud computing resources to process data in real-time is challenging.Edge computing technologies can improve real-time performance ... With the development of the Internet of Things and devices continuing to scale,using cloud computing resources to process data in real-time is challenging.Edge computing technologies can improve real-time performance in processing data.By introducing the FPGA into the computing node and using the dynamic reconfigurability of the FPGA,the FPGA-based edge node can increase the edge node capability.In this paper,a task-based collaborative method for an FPGA-based edge computing system is proposed in order to meet the collaboration among FPGA-based edge nodes,edge nodes,and the cloud.The modeling of the task includes two parts,task information and task-dependent file.Task information is used to describe the running information and dependency infor-mation required for the task execution.Task-dependent file contains the configuration bit-stream of FPGA in running of the task.By analyzing the task behavior,this paper builds four basic behaviors,analyzes the critical attributes of each behavior,and summa-rizes the task model suitable for FPGA-based edge nodes.Tasks with specific functions can be created by modifying different attributes of model nodes.Finally,the availability of the model and the task-based collaborative method are verified by simulation exper-iments.The experimental results that the task model proposed in this paper can meet cloud-edge collaboration in the FPGA-based edge computing environment. 展开更多
关键词 Task modeling edge computing cloud-edge collaboration
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