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Assessment of transplant pharmacy services in medical clinics:a national survey 认领 引用
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作者 Hui Yang Xin Yu +9 位作者 Xiaopeng Hu Kuifen Ma Pan Chen Xiangduan Liu Qing Qian Wenjing Hou Fang Zeng Guangzhao Wang Rongrong Wang Zhuoling An 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2025年第7期674-681,共8页
Pharmacy clinics,staffed by clinical pharmacists who interact directly with patients,encompass services such as medication reconciliation,education,follow-up visits,and lifestyle guidance.Their primary goal is to enha... Pharmacy clinics,staffed by clinical pharmacists who interact directly with patients,encompass services such as medication reconciliation,education,follow-up visits,and lifestyle guidance.Their primary goal is to enhance patients’quality of life.Numerous studies,both domestic and international,have highlighted the benefits of pharmacy clinics in optimizing drug therapy quality and reducing treatment costs,particularly for long-term medication management in organ transplant recipients and similar patient groups.Despite these benefits,pharmacy clinics are still in the early stages of development in China.There remains a lack of clarity regarding the specific development and service content of pharmacy clinics tailored for transplant patients.Therefore,this study aimed to assess the current status of pharmacy clinic development for transplant patients in China and provide insights to hospitals for advancing and strengthening transplant pharmacy clinic initiatives. 展开更多
关键词 Transplant Pharmacy services Pharmacist-managed clinics Survey China
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Cerebral mechanism of puncturing at He-Mu point combination for functional dyspepsia: study protocol for a randomized controlled parallel trial 认领 引用 被引量：13
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作者 Shuai Yin Yuan Chen +13 位作者 Du Lei Rui-rui Sun Ting-ting Ma Pei-min Feng Zhao-xuan He Xue-ling Suo Pei-hong Ma Yu-zhu Qu Ke Qiu Miao-miao Jing Qi-yong Gong Fan-rong Liang Jiao Chen Fang Zeng 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第5期831-840,共10页
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlyin... Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging. A total of 105 patients with functional dyspepsia will be allocated into 3 groups： the low-He point group（puncturing at Zusanli（ST36））, Mu point group（puncturing at Zhongwan（CV12））, and He-Mu point combination group（puncturing at ST36 and CV12）. Every participant will receive 20 sessions of manual acupuncture for 4 weeks. The needles will be inserted perpendicularly to a depth of 1 to 2 cun. The angle of rotation and twisting will range from 90 to 180 degrees, while lifting and thrusting will range from 0.3 to 0.5 cm. The various manipulations will be performed 60 to 90 times per minute. The needles will remain in place for 30 minutes, during which manipulation will be applied every 10 minutes. Magnetic resonance imaging will be performed before and after 20 sessions of acupuncture. The primary outcome is symptom improvement according to the Chinese version of the Nepean Dyspepsia Index. Secondary outcomes include the Leeds dyspepsia questionnaire, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Beck Anxiety Inventory, Beck Depression Inventory, and visual analogue scale scores before and after 10 and 20 sessions of acupuncture. Needle sensation and adverse events will be used to assess the therapeutic effects. This study will promote more widespread awareness of the benefits of acupoint combination in the clinical setting and provide a further explanation of the neuromechanism by which acupuncture at the He-Mu point combination for functional dyspepsia. Registration： Chinese Clinical Trial Registry, Chi CTR-IOR-15006402. 展开更多
关键词 nerve regeneration dyspepsia acupoint combination acupuncture traditional Chinese medicine neuromechanism functional magnetic resonance imaging clinical trial protocol neural regeneration
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Changes of resting cerebral activities in subacute ischemic stroke patients 认领 引用 被引量：11
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作者 Ping Wu Fang Zeng +6 位作者 Yong-xin Li Bai-li Yu Li-hua Qiu Wei Qin Ji Li Yu-mei Zhou Fan-rong Liang 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第5期760-765,共6页
This study aimed to detect the difference in resting cerebral activities between ischemic stroke pa- tients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, cli... This study aimed to detect the difference in resting cerebral activities between ischemic stroke pa- tients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunc- tion and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage （15 days to 11.5 weeks） and 15 age-matched healthy participants. A rest- ing-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely po- tential targets for the neural regeneration of subacute ischemic stroke patients. 展开更多
关键词 nerve regeneration brain injury neuroimaging functional magnetic resonance imaging regional homogeneity apoplexy subacute ischemia participants healthy volunteers brain activity NSFC grants neural regeneration
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Changed ACC-DMN functional connectivity after acupuncture with deqi for functional dyspepsia treatment 认领 引用 被引量：9
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作者 Rui-rui SUN Pei-hong MA +12 位作者 Zhao-xuan HE Tao YIN Yu-zhu QU Shuai YIN Xiao-yan LIU Jin LU Ting-ting ZHANG Liu-yang HUANG Xue-ling SUO Du LEI Qi-yong GONG Fan-rong LIANG Fang ZENG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2021年第1期6-15,共10页
Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD... Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD.Methods:Thirty-two FD patients and 35 healthy subjects(HS)were firstly scanned by the resting-state blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)to compare differences of ACC-based functional connectivity(FC).Then 32 FD patients were randomized to receive 20 sessions’acupuncture treatment with(n=16)and without deqi(n=16),as well as underwent functional magnetic resonance imaging(fMRI)scans after treatment.After group re-division according to deqi response,changes of ACC subregions-based resting-state FC(rsFC)were compared between the actual with and without deqi group.Two seeds with bilateral of each were selected as regions of interest(ROIs)of the ACC,including two from the dorsal ACC:S2(BA24)(x=±5,y=2,z=46,r=3.5 mm)and two from the pregenual ACC:17(BA24)(x=±5,y=38,z=6,r=3.5 mm).The clinical changes of the Nepean Dyspepsia Index(NDI)that measuring symptoms and quality of life(QOL)were also used to further assess the correlation with ACC subregions rsFC in FD patients.Results:Compared to HS,FD patients showed significantly increased ACC subregions rsFC with left fusiform gyrus,temporal cortex,hippocampus(HIPP)/amygdala,temporal pole,and right INS,superior occipital gyrus,and bilateral precuneus,superior parietal lobule(SPL),and decreased rsFC with left postcentral/precentral gyrus(PoG/PrG),supplementary motor area(SMA)and right cerebellum.32 FD patients which were then re-divided into the actual deqi group(n=16)and actual without deqi group(n=16).The decrease of the NDI symptom score(pre-pos)in the actual deqi group was significantly greater than that in the actual without deqi group(P0.05).Conclusion:The results tested the hypothesis that the advantage of deqi on efficacy is related to affecting the ACC subregions rsFC.It suggested that deqi might participate in the adaptive modulation of disrupted relationship between the ACC subregions and the default mode network(DMN). 展开更多
关键词 Deqi Functional dyspepsia ACC subregions Resting-state Functional connectivity
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Regional brain structural abnormality in ischemic stroke patients:a voxel-based morphometry study 认领 引用 被引量：3
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作者 Ping Wu Yu-mei Zhou +14 位作者 Fang Zeng Zheng-jie Li Lu Luo Yong-xin Li Wei Fan Li-hua Qiu Wei Qin Lin Chen Lin Bai Juan Nie San Zhang Yan Xiong Yu Bai Can-xin Yin Fan-rong Liang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1424-1430,共7页
Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these b... Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients. 展开更多
关键词 nerve regeneration ischemic stroke brain structure abnormality Junctional magnetic resonance imaging gray matter density voxel-based morphometry Fugl-Meyer Motor Assessment nervous fi^nctional deficiency scale functional deficiency neuroplasticity neuralreorganization neural regeneration
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The meridian distribution on the lacquer figure unearthed in the Han dynasty tomb in Chengdu Laoguan mountain 认领 引用 被引量：4
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作者 Shi-rui CHENG Xing-lan ZHOU +10 位作者 Ke QIU Rui-rui SUN Yi WANG Shuai YIN Tao XIE Yin-ke LU Jiao CHEN Yu-lan REN Zhong-jun HE Fang ZENG Fan-rong LIANG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2022年第1期40-48,共9页
In 2012,a lacquer figure was unearthed from the Han dynasty tomb(188 BC-87 BC) at Chengdu Laoguanshan.The lines intaglioed on the Laoguan mountain lacquer figure were similar to the meridians.Objective:To investigate ... In 2012,a lacquer figure was unearthed from the Han dynasty tomb(188 BC-87 BC) at Chengdu Laoguanshan.The lines intaglioed on the Laoguan mountain lacquer figure were similar to the meridians.Objective:To investigate the relationship between the lines on this Laoguanshan lacquer figure and the regular meridians so as to explore the development of meridian system in ancient China.Methods:Based on collecting the photos of the Laoguan mountain lacquer figure and the representative acupuncture classics,the double evidence method(combining the unearthed relics/literature and extant literature) was performed to investigate the relationship between the lines on this Laoguanshan lacquer figure and the regular meridians.Furthermore,the development of regular meridians theory was analyzed from the number,distribution,direction and branches.Results:The routes of the 28 longitudinal white lines on the Laoguan mountain lacquer figure are similar to the regular meridians in the ancient literature including Huángdì Nèijīng 《黄帝内经》 Yellow Emperor’s Inner Classic).The number,distribution and branches of the meridians intaglioed on the Laoguanshan lacquer figure suggested the evolution of the regular-meridian system from the eleven-meridian system to the twelve-meridian system.Conclusions:The meridian system of Laoguanshan lacquer figure was a link connecting the preceding and the following.The Laoguanshan lacquer figure played an important role in the development of the early meridian theory. 展开更多
关键词 Meridian theory Lacquer figure Acupuncture Han dynasty tomb in Laoguanshan
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Case-based learning in education of Traditional Chinese Medicine: a systematic review 认领 引用 被引量：33
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作者 Ji Chen Ying Li +3 位作者 Yong Tang Fang Zeng Xi Wu Fanrong Liang 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2013年第5期692-697,共6页
OBJECTIVE:To assess the effect of case-based learning(CBL)in the education of Traditional Chinese Medicine(TCM).METHODS:The studies concerning TCM courses designed with CBL were included by searching the databases of ... OBJECTIVE:To assess the effect of case-based learning(CBL)in the education of Traditional Chinese Medicine(TCM).METHODS:The studies concerning TCM courses designed with CBL were included by searching the databases of EBSCO,Pubmed,Science Citation Index,China National Knowledge Infrastructure,Chongqing VIP database.The valid data was extracted in accordance with the included criteria.The quality of the studies was assessed with Gemma Flores-Masteo.RESULTS:A total of 22 articles were retrieved that met the selection criteria:one was of high quality;two were of low quality;the rest were categorized as moderate quality.The majority of the studiesdemonstrated the better effect produced by CBL,while a few studies showed no difference,compared with the didactic format.All included studies confirmed the favorable effect on learners'attitude,skills and ability.CONCLUSION:CBL showed the desirable results in achieving the goal of learning.Compared to didactic approach,it played a more active role in promoting students'competency.Since the quality of the articles on which the study was based was not so high,the findings still need further research to become substantiated. 展开更多
关键词 Medicine Chinese traditional Complementary therapies Case-based learning Teaching format Systematic review
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Temperature-responsive Behavior of Polymer Fluorescent System via Electrostatic Interaction Mediated Aggregation/Deaggregation 认领 引用
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作者 si-hua guo fang-yuan zheng +1 位作者 fang zeng 吴水珠 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2016年第7期830-837,共8页
A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction betwe... A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction between polyelectrolyte and charged fluorophore. As for the system, the excimer-monomer conversion, thermosensitive behavior and thermo-responsive reversibility were investigated experimentally. Temperature variation and temperature-distribution induced fluorescence changes can be observed directly by naked eyes. Thus, this polymer system holds promise for serving as a fluorescent thermometer. 展开更多
关键词 Polymer fluorescent thermometer Temperature-responsive Electrostatic interaction Aggregation Deaggregation
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Evaluation of Pre-Harvest Sprouting(PHS)Resistance and Screening of High-Quality Varieties from Thirty-Seven Quinoa(Chenopodium quinoa Willd.)Resources in Chengdu Plain 认领 引用
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作者 Xin Pan Ya Gao +5 位作者 Fang Zeng Chunmei Zheng Wenxuan Ge Yan Wan Yanxia Sun Xiaoyong Wu 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第10期2921-2936,共16页
Pre-harvest sprouting(PHS)will have a serious effect both on the yield and quality of quinoa(Chenopodium quinoaWilld.).It is crucial to select and breed quinoa varieties with PHS resistance and excellent agronomic tra... Pre-harvest sprouting(PHS)will have a serious effect both on the yield and quality of quinoa(Chenopodium quinoaWilld.).It is crucial to select and breed quinoa varieties with PHS resistance and excellent agronomic traits for guidance production and utilization of quinoa.A comprehensive evaluation of the PHS resistance and agronomic traits of 37 species of quinoa resources was conducted in Chengdu Plain.The evaluation used various methods,including grain germination rate(GR),grain germination index(GI),total spike germination rate(SR),total grain germination index(SI),grey correlation analysis(GCA),cluster analysis and correlation analysis.Results showed significant differences in PHS resistance and agronomic traits amongst the 37 quinoa resources.CDU-23 was most resistant to PHS within 24 h,with a germination rate of 2.67%and 0%according to the GR and SR results,respectively.However,in the same time,CDU-31 showed the maximum susceptibility to PHS based on the SR of 31.07%,while CDU-34 was the most sensitive to PHS according to the GR of 100%.The comprehensive evaluation identified one and nine kinds of high resistance species for grain and whole spike germination,respectively.In both cases,the coefficients of variation(CV)for these parameters were 34.78%and 82.13%,respectively.GCA results showed that the magnitude of the association between each trait and yield in the thirty-seven quinoa resources was in the following order:thousand grain weight>seed length>seed area>seed width.Although the seed weight of CDU-18 reached 3.7010 g,the seed weight of CDU-5 was only 1.6030 g.However,the size of the seeds,their width and area did not correlate with their 1000-grain weight.There was a complex correlation between PHS resistance index and agronomic traits.Based on clustering analysis,thirty-seven quinoa resources were classified into three taxa.It was found that various taxa differed in PHS resistance and agronomic traits.Several comparisons of the aggregated data led to the selection of five varieties of quinoa,of which CDU-2 presented excellent agronomic qualities and strong PHS resistance.This study has provided a reference for breeding excellent quinoa varieties with PHS resistance. 展开更多
关键词 Quinoa pre-harvest sprouting(PHS) agronomic traits cluster analysis
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A central analgesic mechanism of acupuncture for migraine An ongoing functional MRI study 认领 引用 被引量：4
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作者 Lei Lan Yujie Gao +5 位作者 Fang Zeng Wei Qin Mingkai Dong Mailan Liu Taipin Guo Fanrong Liang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第28期2649-2655,共7页
Shaoyang acupoints are the most frequently used in migraine treatment. However, the central anal- gesic mechanism remains poorly understood. Studies have demonstrated that single stimulus of the verum acupuncture in h... Shaoyang acupoints are the most frequently used in migraine treatment. However, the central anal- gesic mechanism remains poorly understood. Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in pain- related central networks compared with sham acupuncture. However, these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints. Thus, we recruited 100 migraine sufferers and randomly assigned them into five groups： Shaoyang uncommon acupoint, Shaoyang common acupoint, Yangming uncommon acupoint, non-acupoint control, and blank control groups. Subjects were subjected to evaluation of curative effects and functional MRI prior to and after 10 and 20 acupuncture treatments. All subjects were diagnosed by physicians and enrolled following clinical physical examination. Subjects were observed during 1-4 weeks after inclusion. At the fifth week, the first clinical evaluation and resting functional MRI were conducted. The Shaoyang uncom- mon acupoint, Shaoyang common acupoint, Yangming uncommon acupoint, and non-acupoint control grousp then were treated with acupuncture, five times per week, 20 times in total over 4 weeks. The second and third clinical evaluations and resting functional MRI screenings were conducted following 10 and 20 acupuncture treatments. The blank control group was observed during the 5 to 8 week pe- riod, followed by clinical evaluation and resting functional MRI. The aim of this study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acu- puncture at Shaoyang uncommon acupoints. This study provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine, 展开更多
关键词 neural regeneration acupuncture and moxibustion migraine acupuncture analgesia central re-sponse functional MRI sessions of acupuncture continuous central activity study design grants-supported paper neuroregeneration
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单中心和多中心型Castleman病的诊疗对比体会 认领 引用
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作者 周芳 覃宝珍 +3 位作者 贾浩 方锃 苏曦 李朋 《罕少疾病杂志》 2025年第4期139-141,共3页
目的对比单中心型与多中心型Castleman病在临床诊断、治疗及预后方面的差异,以实现临床精准诊疗。方法回顾性分析1例单中心型和1例多中心型Castleman病患者的诊疗流程及预后情况。结果单中心型Castleman病患者主要临床表现为颈部肿块,... 目的对比单中心型与多中心型Castleman病在临床诊断、治疗及预后方面的差异,以实现临床精准诊疗。方法回顾性分析1例单中心型和1例多中心型Castleman病患者的诊疗流程及预后情况。结果单中心型Castleman病患者主要临床表现为颈部肿块,经手术完整切除后,定期随访4年未见复发;多中心型Castleman病患者以副肿瘤性天疱疮起病,全身症状及器官损害症状显著,且合并阻塞性细支气管炎,在化疗过程中因发生呼吸衰竭而中断治疗,预计预后较差。结论单中心型Castleman病通常表现为单个区域淋巴结肿大,通过完整手术切除可获得良好预后。多中心型Castleman病则累及全身多个区域淋巴结,其治疗原则为激素联合生物治疗及化疗的综合性全身治疗,手术仅用于诊断性活检。此外,多中心型患者可合并闭塞性细支气管炎,预后相对较差。 展开更多
关键词 单中心型Castleman病 多中心型Castleman病 诊疗 预后
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An acupuncture meta-analysis for optic atrophy Seven randomized,controlled trials 认领 引用 被引量：2
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作者 Mailan Liu Lei Lan +4 位作者 Yong Tang Fang Zeng Haiyan Yin Mei Huang Fanrong Liang 《Neural Regeneration Research》 SCIE CAS 2009年第12期994-1001,共8页
OBJECTIVE:To evaluate the efficacy and safety of acupuncture for optic atrophy.DATA SOURCES:A computer-based online search was conducted in Medline(1966-2008),Embase(1986-2008),the Cochrane Library(up to 2008),Chinese... OBJECTIVE:To evaluate the efficacy and safety of acupuncture for optic atrophy.DATA SOURCES:A computer-based online search was conducted in Medline(1966-2008),Embase(1986-2008),the Cochrane Library(up to 2008),Chinese Biomedical Literature Database(1975-2008),China National Knowledge Infrastructure(1994-2008),VIP Database(1989-2008),Wanfang Database(1980-2008)and the National Research Register for ongoing trials.DATA SELECTION:Randomized,controlled trials addressing acupuncture treatment for patients with optic atrophy were included in this review.Inclusion criteria evaluated all forms of acupuncture therapy,such as filiform needle,electro-acupuncture,laser-acupuncture,acupressure,and auricular-acupuncture.Comparisons between acupuncture therapy and no treatment(blank)or placebo or Chinese medicine or Western medicine,as well as between acupuncture as an adjuvant and other treatments,were included.Exclusion criteria included studies comparing different forms of acupuncture therapy,different manipulations of acupuncture,and different acupuncture prescriptions,as well as non-randomized,controlled trials and animal studies.The domain-based evaluation criteria recommended by the guidelines in Chapter 8 of the Cochrane Handbook for Systematic Reviews of Interventions 5.0.1 was used to assess quality of the included studies.According to the type of outcome index,measurement data as assessed by weighted mean difference or standardized mean difference and 95%confidence interval;numeration data was estimated by relative risk and 95%confidence interval.Heterogeneity was analyzed by Meta-analysis using RevMan 5.0 software.MAIN OUTCOME MEASURES:Improved visual acuity and visual field was sought between treatment and control groups in the included articles.RESULTS:Seven randomized,controlled trials were included after screening and application of inclusion and exclusion criteria.However,the studies were of low methodological quality and lacked comparisons between acupuncture and no treatment or placebo.Applying visual acuity as the outcome index,meta-analysis indicated:the effect of medicine combined with acupuncture was superior to the medicine alone(relative risk=1.41,95%confidence interval 1.14-1.70,P〈0.01),the efficacy of acupuncture was better than medicine alone(relative risk=1.42,95%confidence interval 1.14-1.77,P〈0.01).Using visual field as the other outcome index,meta-analysis revealed:effectiveness of acupuncture or acupuncture in combination with medicine was superior to medicine alone(relative risk=1.47,95%confidence interval 1.27-1.69,P〈0.01).The 7 included articles were incorporated in a sensitivity analysis,and the overall effect showed a significant difference(relative risk=1.35,95%confidence interval 1.16-1.56,P〈0.01).Acupuncture was not associated with any adverse events in any of the studies.CONCLUSION:Acupuncture therapy was determined to be superior to medicine in terms of improved visual acuity and visual field.However,well-designed,randomized,controlled trials with adequate controls and scientific rigor are urgently needed. 展开更多
关键词 acupuncture therapy optic atrophy effectiveness Meta-analysis
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聚集诱导发光 认领 引用 被引量：42
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作者 韩鹏博 徐赫 +73 位作者 安众福 蔡哲毅 蔡政旭 巢晖 陈彪 陈明 陈禹 池振国 代淑婷 丁丹 董宇平 高志远 管伟江 何自开 胡晶晶 胡蓉 胡毅雄 黄秋忆 康苗苗 李丹霞 李济森 李树珍 李文朗 李振 林新霖 刘骅莹 刘佩颖 娄筱叮 吕超 马东阁 欧翰林 欧阳娟 彭谦 钱骏 秦安军 屈佳敏 石建兵 帅志刚 孙立和 田锐 田文晶 佟斌 汪辉亮 王东 王鹤 王涛 王晓 王誉澄 吴水珠 夏帆 谢育俊 熊凯 徐斌 闫东鹏 杨海波 杨清正 杨志涌 袁丽珍 袁望章 臧双全 曾钫 曾嘉杰 曾卓 张国庆 张晓燕 张学鹏 张艺 张宇凡 张志军 赵娟 赵征 赵子豪 赵祖金 唐本忠 《化学进展》 SCIE CAS CSCD 北大核心 2022年第1期1-130,共130页
聚集诱导发光(AIE)是唐本忠院士于2001年提出的一个科学概念,是指一类在溶液中不发光或者发光微弱的分子聚集后发光显著增强的现象。高效固态发光的AIE材料有望从根本上解决有机发光材料面临的聚集导致发光猝灭难题,具有重大的实际应用... 聚集诱导发光(AIE)是唐本忠院士于2001年提出的一个科学概念,是指一类在溶液中不发光或者发光微弱的分子聚集后发光显著增强的现象。高效固态发光的AIE材料有望从根本上解决有机发光材料面临的聚集导致发光猝灭难题,具有重大的实际应用价值。从分子内旋转受限到分子内运动受限,从聚集诱导发光到聚集体科学,AIE领域已经取得了许多原创性的成果。在本综述中,我们从AIE材料的分类、机理、概念衍生、性能、应用和挑战等方面讨论了AIE领域最近取得的显著进展。希望本综述能激发更多关于分子聚集体的研究,并推动材料、化学和生物医学等学科的进一步交叉融合和更大发展。 展开更多
关键词 聚集诱导发光 聚集体科学 分子内运动受限
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醌氧化还原酶响应型光声探针的合成及其对乳腺癌的成像 认领 引用 被引量：5
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作者 黄靖 王超 +2 位作者 林敏刚 曾钫 吴水珠 《化学学报》 SCIE CAS CSCD 北大核心 2021年第3期331-337,共7页
醌氧化还原酶(NQO1)是生物体内的一种双电子还原反应的专性催化还原酶.在一些疾病如乳腺癌中NQO1过度表达,因此NQO1可作为生物标志物以观察乳腺癌肿瘤的产生和发展.目前已有一些文献报导用于NQO1检测和荧光成像的荧光探针,但大部分这些... 醌氧化还原酶(NQO1)是生物体内的一种双电子还原反应的专性催化还原酶.在一些疾病如乳腺癌中NQO1过度表达,因此NQO1可作为生物标志物以观察乳腺癌肿瘤的产生和发展.目前已有一些文献报导用于NQO1检测和荧光成像的荧光探针,但大部分这些探针具有吸收波长较短、背景干扰较强、组织穿透深度较低等不足.为克服荧光探针成像的上述缺陷,我们构建出一种具有推拉电子结构的可对NQO1响应的新型近红外光声探针TPA-X-Q.实验结果表明,该探针可在生物体内和体外对NQO1进行专一性的增强型光声检测和成像,并可提供高分辨率的实时光声信号图像.此外,这种新型的光声探针能够成功应用于乳腺癌小鼠模型,对乳腺癌肿瘤中过量表达的NQO1进行灵敏准确的光声检测与成像,借助多光谱光声断层扫描技术(MSOT)的三维光声图像重建功能,可实现肿瘤病灶区域的定位. 展开更多
关键词 醌氧化还原酶 探针 近红外 乳腺癌 多光谱光声断层扫描
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奥卡西平联合拉莫三嗪对癫痫患儿NSE、GFAP水平的影响 认领 引用 被引量：16
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作者 曾芳 任晓幸 黎玉环 《中国现代医学杂志》 CAS 2019年第10期91-95,共5页
目的探究奥卡西平联合拉莫三嗪治疗癫痫患儿的疗效,以及对神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)水平的影响。方法选取2015年1月—2017年12月郑州大学附属郑州中心医院收治的94例癫痫患儿,随机分为观察组和对照组,对照组... 目的探究奥卡西平联合拉莫三嗪治疗癫痫患儿的疗效,以及对神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)水平的影响。方法选取2015年1月—2017年12月郑州大学附属郑州中心医院收治的94例癫痫患儿,随机分为观察组和对照组,对照组口服奥卡西平,观察组在对照组的基础上口服拉莫三嗪,治疗6个月后,对两组患儿临床疗效、不良反应发生率、治疗前后脑电图变化情况进行比较,同时检测NSE、GFAP等指标的水平。结果观察组的治疗总有效率为91.49%,对照组为74.47%,经χ~2检验,差异有统计学意义(P <0.05),观察组不良反应发生率仅为8.51%,对照组为21.28%,经χ~2检验,差异有统计学意义(P<0.05)。观察组患儿治疗后θ频段功率低于对照组(P<0.05)。结论奥卡西平联合拉莫三嗪可有效提高癫痫的治疗效果,减少服药期间不良反应发生率,值得在临床中推广应用。 展开更多
关键词 癫痫 奥卡西平/处方药 拉莫三嗪/处方药 神经元特异性烯醇化酶/磷酸丙酮酸水合酶
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我国人群血清PLA2R抗体诊断IMN的最佳截断值探讨 认领 引用 被引量：2
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作者 黄其鹏 徐高四 +2 位作者 王芳 曾芳 方卫东 《中国现代医学杂志》 CAS 2019年第2期97-100,共4页
目的血清磷脂酶A2受体(PLA2R)抗体对特发性膜性肾病(IMN)的诊断价值已经得到广泛认同,但国外血清PLA2R抗体对IMN的诊断截断值不一定适合我国,因此笔者拟探讨我国血清PLA2R抗体诊断IMN的最佳截断值。方法选取2016年1月—2018年1月于江西... 目的血清磷脂酶A2受体(PLA2R)抗体对特发性膜性肾病(IMN)的诊断价值已经得到广泛认同,但国外血清PLA2R抗体对IMN的诊断截断值不一定适合我国,因此笔者拟探讨我国血清PLA2R抗体诊断IMN的最佳截断值。方法选取2016年1月—2018年1月于江西省赣州市人民医院肾内科住院行肾穿刺活检的患者,采用酶联免疫吸附法检测血清PLA2R抗体,其诊断价值行ROC曲线分析,探讨血清PLA2R抗体诊断IMN的敏感性和特异性,取约登指数最大时的检测值作为阳性截断值。结果血清PLA2R抗体诊断IMN的曲线下面积(AUC)为0.924(95%CI:0.844,1.000),与机会一致性诊断AUC=0.5比较,差异有统计学意义(P <0.05)。当截断值取2.92 Ru/ml时,敏感性为0.818(95%CI:0.750,0.876),特异性为0.935(95%CI:0.888,0.966),阳性预测值为0.900,阴性预测值为0.879,约登指数为0.753。结论目前被广泛采用的血清PLA2R抗体对诊断IMN的临界值仍需要通过多中心大样本量的研究来进一步探讨和修正。 展开更多
关键词 抗磷脂酶A2受体抗体/抗体 特发性膜性肾病/肾病 ROC曲线 曲线下面积 穿刺术
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Computer Assisted Pathway Generation for Atrazine Degradation in Advanced Oxidation Processes 认领 引用
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作者 Xiang Li Fang Zeng Ke Li 《Journal of Environmental Protection》 2013年第1期62-69,共8页
A model was developed to generate the complex degradation pathway of contaminants initiated by hydroxyl radical in the advanced oxidation processes. The model abstracts chemical structures into mathematic graphs. The ... A model was developed to generate the complex degradation pathway of contaminants initiated by hydroxyl radical in the advanced oxidation processes. The model abstracts chemical structures into mathematic graphs. The manipulation of the graphs enumerates the reactions among the large number of molecules, radicals, and other intermediates in the advanced oxidation processes. Using Canonical Simplified Molecular Input Line Entry Specification (Canonical SMILE) representation, the algorithm was able to simulate the reaction of contaminants containing both chain and ring structures. The input chemicals, reaction pattern, and the reaction rules could be specified by users through a graphical user interface. The degradation pathway of Atrazine was used as an example to demonstrate the capability of the algorithm. The generated reaction pathways were compared with those reported in literatures. 展开更多
关键词 Advanced Oxidation Processes Modeling Atrazine Mechanism Study
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数智循证医学:AI时代循证研究与实践新方向 认领 引用 被引量：8
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作者 赖鸿皓 马宁 +23 位作者 赵威龙 刘嘉艺 潘蓓 田金徽 陈耀龙 马彬 商洪才 刘建平 卞兆祥 吴大嵘 孙鑫 杜亮 张俊华 刘新灿 曾芳 孙凤 张博恒 靳英辉 夏君 史楠楠 刘琴 杨克虎 葛龙 黄璐琦 《科学通报》 EI CAS CSCD 北大核心 2026年第2期449-463,共15页
人工智能技术的快速发展,特别是其在处理复杂医学数据方面的突破性能力,正在重塑医学证据的生成、整合与应用模式.传统循证医学(evidence-based medicine,EBM)虽然在过去30年中显著提升了医学决策的科学性,但其固有的时滞性、证据孤岛... 人工智能技术的快速发展,特别是其在处理复杂医学数据方面的突破性能力,正在重塑医学证据的生成、整合与应用模式.传统循证医学(evidence-based medicine,EBM)虽然在过去30年中显著提升了医学决策的科学性,但其固有的时滞性、证据孤岛化以及个体化不足等局限性,在当前医学复杂性急剧增加的背景下愈发凸显.团队提出“数智循证医学”(digital intelligent evidence-based medicine,i-EBM)这一新型现代医学范式构想,其核心特征体现在三个维度:整合性(integrated)的多源数据融合、智能化(intelligent)的证据分析与生成、个体化(individualized)的精准决策支持.i-EBM并非对传统EBM的颠覆,而是其在人工智能时代的必然演化,旨在通过机器智能与人类专业知识的深度协同,构建一个动态、精准、高效的新一代医学证据体系.同时,对于中医药复杂干预特征与辨证论治规律的量化研究等问题,i-EBM可在数据整合、模式识别与因果推断等方面提供支持,为揭示中医药证据内在规律与优化循证评价体系提供潜在的工具与思路. 展开更多
关键词 数智循证医学 人工智能 大数据 中医药 个体化医学
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中国23家肾移植中心抗菌药物管理现状调查 认领 引用
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作者 杨波 温爱萍 +8 位作者 马葵芬 刘相端 杨辉 钱卿 陈攀 曾芳 王融溶 王广钊 侯文婧 《中华移植杂志（电子版）》 CAS 2026年第2期91-95,共5页
目的调查肾移植中心抗菌药物管理(AMS)现状,为进一步规范抗菌药物合理用药提供参考。方法2023年4月4日至5月12日,面向全国移植药师联盟成员中来自50家医院的肾移植专科临床药师开展在线调查,收集其所在医院及肾移植中心AMS相关情况。通... 目的调查肾移植中心抗菌药物管理(AMS)现状,为进一步规范抗菌药物合理用药提供参考。方法2023年4月4日至5月12日,面向全国移植药师联盟成员中来自50家医院的肾移植专科临床药师开展在线调查,收集其所在医院及肾移植中心AMS相关情况。通过问卷星平台设计并发布肾移植中心AMS现状调查问卷,内容包括受访药师及其所在医院的基本信息、抗菌药物临床应用管理评价指标及完成情况、药师采取的干预措施与成效、药师对肾移植围手术期感染预防方案的合理性评价与建议等。结果共23位来自23家三级甲等教学医院的移植药师参与调查。21家(91.3%)医院开展AMS,仅10家(43.5%)涉及肾移植中心。各中心抗菌药物使用强度目标值存在较大差异,5家(21.7%)未达标。22位药师采取过干预措施以改善抗菌药物合理使用,具体措施包括:开展培训(19位、86.4%),行政干预(12位、54.5%),利用合理用药软件辅助AMS管理(6位、27.3%)。干预效果主要体现为:疗程缩短(18位、81.8%),用药品种调整(12位、54.5%),联合用药品种数减少(11位、50.0%),给药剂量减少(6位、27.3%)。12位(52.2%)药师认可所在肾移植中心目前的肾移植手术常规感染预防方案,但不同药师对同一方案的评价结果并不统一。结论我国肾移植中心AMS开展率较低,在AMS目标及执行情况等方面存在较大差异,尚需开展高质量研究探索同质化管理策略,以规范抗菌药物合理使用。 展开更多
关键词 肾移植 抗菌药物管理 药师干预 调查问卷
Highly dispersed Ni/MgO-mSiO2catalysts with excellent activity and stability for dry reforming of methane 认领 引用 被引量：8
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作者 Fang Zeng Juan Zhang +2 位作者 Run Xu Rongjun Zhang Jianping Ge 《Nano Research》 SCIE EI CSCD 2022年第6期5004-5013,共10页
Highly dispersed Ni catalyst and alkaline promoters supported by mesoporous SiO2nanospheres were synthesized and applied as an active and stable catalyst for dry reforming of methane(DRM).The as-prepared Ni/MgO-mSi... Highly dispersed Ni catalyst and alkaline promoters supported by mesoporous SiO2nanospheres were synthesized and applied as an active and stable catalyst for dry reforming of methane(DRM).The as-prepared Ni/MgO-mSiO2catalyst showed stable conversions of CH4 and CO2around 82%and 85%in 120 h of DRM reaction,which was superior in performance compared to similar catalysts in literatures.Based on the transmission electron microscope(TEM)images,energy-dispersive spectroscopy(EDS),CO-pulse adsorption,temperature programmed reduction of the oxidized catalysts by hydrogen(H2-TPR),X-ray photoelectron spectroscopy(XPS),temperature-programmed desorption of CO2(CO2-TPD),and thermal gravitational analysis(TGA),the promotion effect of MgO on the Ni catalyst was systematically studied.The introduction of Mg2+in synthesis enhanced the interaction between Ni2+and mSiO2,which led to a high dispersion of active centers and a strong“metal–support”interactions to inhibit the sintering and deactivation of Ni at reaction temperatures.On the other hand,Ni and MgO nanoparticles formed adjacently on mSiO2,where the“Ni-MgO”interface not only improved the Ni0 distribution and promoted the cracking of CH4but also promoted the activation of CO2and the elimination of carbon deposits.A high and stable conversion of CH4 and CO2were then achieved through the synergistic effect of Ni catalyst,MgO promoter,and mSiO2support. 展开更多
关键词 Ni-based catalyst dry reforming of methane mesoporous SiO2 MgO alkaline
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