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Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes:A clinical practice guideline from the Chinese Society of Endocrinology 认领 引用 被引量：1
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作者 Fang Zhang Jiajun Zhao +9 位作者 Yuwei Zhang Zhenjun Tian Jing Li Qingguo Lv Weiqing Wang Tianpei Hong Zhongyan Shan Li Yan Yongde Peng Nanwei Tong 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第5期44-76,共33页
Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of End... Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of Endocrinology,synthesizes the latest evidence and expert insights to provide evidence-based recommendations for physical activity and exercise therapy in adults with type 2 diabetes(T2D).It is generally recommended that all adult patients with T2D engage in at least 150—300 min of moderate-intensity aerobic exercise per week,or a minimum of75—150 min of vigorous-intensity exercise,or an equivalent combination of moderate-and vigorous-intensity exercise(with a total exercise volume of at least 450 metabolic equivalent-min per week).For patients with T2D who are capable,moderate over-exercise and a combination of different forms of exercise(aerobic,resistance,flexibility,and/or balance training)are encouraged.The guideline also underscores the necessity of targeting specific subgroups of patients with T2D,including the elderly,individuals with obesity or pre-obesity,cardiovascular disease,hypertension,chronic kidney disease,metabolic dysfunction-associated steatotic liver disease,and/or diabetic foot and its high-risk populations.The guideline provides a scientific basis for clinicians to develop personalized exercise guidance and recommendations,with the goal of improving the disease prognosis of the relevant population. 展开更多
关键词 Adult Exercise Physical activity Type 2 diabetes Therapy principle
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Spatial variability of groundwater nitrate in the loess area of Tongchuan City,China:New insights from farmland leaching quantification 认领 引用
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作者 Wei Zhao Peiyue Li +5 位作者 Tiantian Wang Fangqiang Sun Fang Zhang Jia Yang Jing Ning Misbah Fida 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期512-521,共10页
High groundwater nitrate associated with agricultural activity is a global environmental problem.However,linking spatial variability of groundwater nitrate and agricultural activity quantification needs to be elucidat... High groundwater nitrate associated with agricultural activity is a global environmental problem.However,linking spatial variability of groundwater nitrate and agricultural activity quantification needs to be elucidated.This paper seeks to explain the spatial variability of groundwater nitrate in the loess area of Tongchuan City,China,identify the contributing factors using hydrogeochemical and statistical methods,and analyze the connection between farmland leaching and groundwater nitrate quantitatively.Results indicate that the nitrate of the Quaternary alluvial pore water(QAP)is significantly higher during the wet season(3.60 to 68.24 mg/L)compared to the dry season(3.53 to 37.20 mg/L).QAP nitrate is significantly higher than that in loess fissure-pore water(LFP),which ranges from 0.66 to 5.47 mg/L during the wet season and 0.82 to 5.01 mg/L during the dry season.The thin and loose vadose zone of QAP makes the aquifer particularly susceptible to anthropogenic influences.Following recharge from LFP,the hydrochemical parameters in QAP increased by 1.22 to 3.12 times(except Na+and pH),the change of average nitrate concentration in QAP(10.11 mg/L)was considerably higher than that in LFP(0.03 mg/L)due to farmland leaching.A significant correlation(R2=0.70 exists between groundwater nitrate and farmland leaching in river valleys and on slopes where farmland is prevalent.Fertilizer accumulation in river valleys enhances downward leaching,thereby further exacerbating groundwater nitrate.These findings highlight that river valleys with extensive farmland in the Loess Plateau should be prioritized for preventing and controlling groundwater nitrate pollution from agricultural activities. 展开更多
关键词 Spatial variability Hydrogeochemistry Statistical analysis Quantitative analysis Farmland leaching
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Resilience of Dehalococcoides enables complete reductive dechlorination of trichloroethene to ethene under high PFOS stress 认领 引用
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作者 Fang Zhang Runlei Ge +4 位作者 Chongwen Shi Tao Long Kun Yang Guanghe Li Lifeng Cao 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第6期105-117,共13页
Perfluorooctane sulfonate(PFOS)is a dominant per-and polyfluoroalkyl substance(PFAS)at aqueous film-forming foam-impacted sites,yet its specific inhibitory effect on reductive dechlorination of trichloroethene(TCE)rem... Perfluorooctane sulfonate(PFOS)is a dominant per-and polyfluoroalkyl substance(PFAS)at aqueous film-forming foam-impacted sites,yet its specific inhibitory effect on reductive dechlorination of trichloroethene(TCE)remains poorly understood.We investigated TCE dechlorination in a Dehalococcoides(Dhc)and Dehalogenimonas(Dhg)-containing consortium under PFOS stress(20-100 mg/L).While the initial TCE dechlorination rates decreased with increasing PFOS concentrations,the final step of vinyl chloride dechlorination to ethene remained largely unaffected.Microbial community analysis revealed that Dhc and Acetobacterium exhibited greater resilience to 100 mg/L PFOS than Dhg and Clostridium_sensu_stricto_7,with alpha diversity significantly reduced at 100 mg/L PFOS.PFOS,but not perfluorooctanoic acid,was identified as the primary inhibitor of TCE dechlorination.Metagenomic sequencing identified two PFOS-tolerant Dhc strains(THU3 and THU4)that harbored specific reductive dehalogenase genes(vcrA and tceA).Our findings demonstrate the functional resilience of Dhc and its potential as a key agent for bioremediation at PFAS-co-contaminated sites. 展开更多
关键词 PFOS inhibition Reductive dechlorination Dehalococcoides Resilience
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Role of physical therapy in irritable bowel syndrome:Current strategies and prospective options 认领 引用
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作者 Jing Chai Zhen-Yi Wang +7 位作者 Zhi-Jun Weng Zi-Jun Zhang Lu-Yi Wu Fang Zhang Lu-Lu Cao Zi-Yi Chen Huan-Gan Wu Hui-Rong Liu 《World Journal of Gastroenterology》 SCIE CAS 2026年第29期27-43,共17页
Irritable bowel syndrome(IBS)is a chronic functional gastrointestinal disorder characterized by dysregulation of the gut-brain interaction.It has a high global prevalence,significantly impairs quality of life,and impo... Irritable bowel syndrome(IBS)is a chronic functional gastrointestinal disorder characterized by dysregulation of the gut-brain interaction.It has a high global prevalence,significantly impairs quality of life,and imposes a substantial socioeconomic burden.The pathophysiology of IBS is complex and not yet fully elucidated,with its heterogeneity reflecting the interplay of multiple factors,including abnormal gastrointestinal motility,visceral hypersensitivity,gut microbiota dysbiosis,low-grade inflammation,and central nervous system dysfunction.This mechanistic complexity not only accounts for the highly individualized symptom profile of IBS but also highlights the limitations of monotherapy in addressing the long-term management needs of patients.Given the limited efficacy,frequent adverse effects,and insufficient adaptability of pharmacological treatments to the heterogeneity of IBS,non-pharmacological interventions have increasingly attracted attention.Among these,physical therapies-using electrical,magnetic,thermal,photic,or mechanical stimulation-can modulate neural activity at central,peripheral,and autonomic levels and have shown promising potential in alleviating IBS symptoms.The underlying mechanisms of physical therapies for IBS are proposed to involve neural modulation,visceral sensory regulation,immunoinflammatory control,and optimization of gut-brain axis function,representing a multi-system,synergistic mode of action.This narrative review synthesizes and contextualizes recent advances in emerging physical therapies for IBS,with a focus on clinical efficacy,safety,and feasibility,while discussing their potential mechanisms within a unified theoretical framework.The current limitations of the evidence,including small sample sizes,inconsistent intervention parameters,and insufficient mechanistic validation,are also addressed.Finally,future research directions are proposed,encom-passing mechanism-driven clinical studies,standardization of intervention parameters,and high-quality rando-mized controlled trials.Overall,physical therapy offers a non-pharmacological,multi-mechanistic intervention capable of modulating multiple physiological systems. 展开更多
关键词 Irritable bowel syndrome Physical therapy Non-pharmacological treatment Exercise therapy Acupuncture
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Health effects of PFASs on five major human cancers:A network toxicology perspective on molecular pathogenesis 认领 引用
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作者 Zhen Qi Xuefei Yang +5 位作者 Zhuning Geng Lina Zhang Ziqing Huang Chongwen Shi Qianli Xie Fang Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期307-321,共15页
Cohort studies and animal experiments showing the burgeoning human cancer risks associated with per-and polyfluoroalkyl substances(PFASs)have garnered increasing concern.However,research detailing the carcinogenic mec... Cohort studies and animal experiments showing the burgeoning human cancer risks associated with per-and polyfluoroalkyl substances(PFASs)have garnered increasing concern.However,research detailing the carcinogenic mechanisms of PFASs specifically remains limited.Based on network toxicology,and high-throughput sequencing data,we analyzed the carcinogenic effects of perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS)in the top five major human cancer types(over 1 million new cases per year):gastric,colorectal,liver,kidney,and breast cancer.A total of 24 pathways associated with PFOS carcinogenesis were enriched,of which 9 pathways were found in different cancers.Notably,Ribosome pathways are enriched in rectal cancer,liver cancer,and kidney cancer.As for PFOA,32 pathways associated with PFOS carcinogenesis were enriched,of which 10 pathways were found in different cancers,notably the peroxisome proliferator-activated receptor(PPAR)signaling pathway is enriched in all five major human cancers.PFOA-induced cancer mainly through the PPAR pathway,while PFOS-induced cancer by disturbing reactive oxygen species and ribosomes.These results indicated that although PFOA and PFOS have analogous structures,they have different mechanisms.This work provides a solid basis for health assessment of PFASs and determining potential pathways before verifying the mechanism of PFASs-induced cancer. 展开更多
关键词 PFASs Network toxicology Carcinogenicity Reactive oxygen species Peroxisome proliferator-activated receptor Ribosome
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A Dual-Function Mitochondria-Targeted Polyoxometalate Nanomicelle Boosts Pyroptosis-Dependent Antitumor Immune Response in Triple-Negative Breast Cancer 认领 引用
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作者 Qingqing Dou Peixiao Jiang +4 位作者 Fang Zhang Kun Yang Zhichao Li Mo Zhang Jing Wang 《Rare Metals》 SCIE EI CAS CSCD 2026年第5期513-526,共14页
The efficacy of immunotherapy in triple-negative breast cancer(TNBC)is often limited,whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy.To address this ... The efficacy of immunotherapy in triple-negative breast cancer(TNBC)is often limited,whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy.To address this challenge,this study developed a reactive oxygen species(ROS)-responsive and mitochondria-targeted nanomicelle(POM@CTT).Upon encountering high ROS within mitochondria,POM@CTT could rapidly release the polyoxometalate(POM)component and generate singlet oxygen.Beyond inducing pyroptosis via the NLRP3/Caspase-1/GSDMD axis,POM disrupted both the cellular and mitochondrial membranes based on the GSDMD N-terminal fragment.This disruption further promoted mitochondrial DNA(mtDNA)release into the cytosol to activate the cGAS-STING pathway.POM concurrently disrupted lysosomal function to block autophagic flux effectively.This blockade prevented pyroptosis-induced compensatory mitophagy,which sustained and amplified the mtDNAcGAS-STING axis-mediated immune activation signal.In vivo,POM@CTT significantly promoted T-cell infiltration into tumors.Its combined use withαPD-L1 remarkably suppressed both primary and distant tumors and effectively prolonged the survival of tumor-bearing mice.This study provides a novel strategy for overcoming TNBC immunotherapy resistance by inducing pyroptosis and blocking autophagic flux synergistically to remodel the tumor immune microenvironment. 展开更多
关键词 autophagic flux blockade cGAS-STING pathway immunotherapy polyoxometalate pyroptosis
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High-performance micron-sized porous Si/C anodes from natural graphite tailings for lithium-ion batteries 认领 引用
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作者 Yuxuan Zhang Chen Wang +4 位作者 Fang Zhang Yan Xin Bijiao He Shiguo Zhang Huajun Tian 《Metals Advances》 SCIE EI CAS CSCD 2026年第6期88-98,共11页
With the growing demand for high-energy-density and long-lifespan lithium-ion batteries(LIBs),silicon/graphite composites have emerged as promising anode materials,as they synergize the ultrahigh capacity of silicon(S... With the growing demand for high-energy-density and long-lifespan lithium-ion batteries(LIBs),silicon/graphite composites have emerged as promising anode materials,as they synergize the ultrahigh capacity of silicon(Si)and the structural stability of carbon.To address the intrinsic volume variation issue of silicon,this work demonstrates a scalable and environmentally benign synthesis of micron-sized porous silicon/graphite composites(NGT-pSi/C)via the integration of FeCl3-etched spherical porous silicon(pSi)and waste-derived natural graphite tailings(NGT).The as-prepared NGT-pSi/C features a watermelon-like multi-core—shell architecture.The pores in pSi effectively accommodate the large volume expansion during cycling.Meanwhile,the upcycled NGT form a conductive layer to disperse mechanical stress,and the glucose-derived carbon layer constructs a conductive network.This waste-to-wealth approach enables the conversion of industrial byproducts into highperformance LIB anode materials.Comprehensive physicochemical and electrochemical characterizations reveal that abundant pores and continuous conductive networks in NGT-pSi/C synergistically mitigate Si pulverization,suppress interfacial degradation and enhance charge transfer kinetics.The NGT-pSi/C anode delivers exceptional cycling stability(591.2 mAh g-1after 400 cycles at 0.5 A g-1)and superior rate capability.Furthermore,full cells paired with NCA90(LiNi0.9Co0.05Al0.05O2)cathodes maintain 72.6%of their initial capacity after 800 cycles.The corresponding pouch cell exhibits a high discharge capacity of 0.7 Ah and retains 74.43%capacity after 500 cycles.This practical strategy achieves a cost-performance synergy.Overall,by using near-zero-cost graphite waste and adopting a non-acidic etching process,this work establishes a sustainable and economically viable pathway for the scalable production of high-performance Si-based anodes. 展开更多
关键词 Silicon/graphite anode Natural graphite tailing Porous silicon anode Pouch cell Lithium-ion batteries
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Circadian rhythm disruption alters gray and white matter microstructure:Higher-order diffusion analysis coupled with hormonal/inflammatory biomarkers 认领 引用
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作者 Fang Zhang Wei-Yuan Huang +3 位作者 Lei Zhang Zhuo-Ran Huang Wei Zhao Yong-Qiang Yu 《World Journal of Psychiatry》 SCIE 2026年第6期368-378,共11页
BACKGROUND The hypothalamic suprachiasmatic nucleus,as the master circadian pacemaker,coordinates circadian homeostasis via neuroendocrine signaling networks.Circadian rhythm disruption(CRD)denotes functional impairme... BACKGROUND The hypothalamic suprachiasmatic nucleus,as the master circadian pacemaker,coordinates circadian homeostasis via neuroendocrine signaling networks.Circadian rhythm disruption(CRD)denotes functional impairment of this system,driven by etiologies ranging from environmental stressors to intrinsic insults,triggering pathophysiological cascades.AIM To delineate neuroendocrine-immune circuits in female textile workers with CRD by integrating diffusion spectrum imaging(DSI)-based neurite orientation dispersion and density imaging(NODDI)with biochemical indices,in order to identify specific biomarkers linked to circadian-hormonal-inflammatory crosstalk.METHODS This prospective observational study included 55 female patients with CRD(≥10 annual night-shift cycles)and 41 age-,sex-,and education-matched controls.A comprehensive multimodal assessment was performed,including quantitative DSI-based NODDI analysis of gray and white matter regions,serum biomarker profiling,standardized neuropsychological evaluations,and statistical analysis of group differences.Within the CRD group,interrelations among multimodal variables were explored using correlation analyses.RESULTS Compared with controls,the CRD group showed significantly higher volume fraction of the isotropically diffusing water and intracellular volume fraction(ICVF)values in seven gray matter regions(P<0.05),primarily within the default mode network and visual network(VN);white matter ICVF was also elevated in three fiber tracts associated with the VN.The CRD group had poorer neurofunctional performance compared to controls.The CRD group also demonstrated increased triiodothyronine(T3;2.33 nmol/L vs 2.02 nmol/L),prolactin(303.20μIU/mL vs 249.60μIU/mL),neutrophil-to-lymphocyte ratio(2.02 vs 1.80);and decreased thyrotropin receptor antibody(0.75 IU/L vs 0.98 IU/L)and luteinizing hormone(14.77 mIU/mL vs 24.29 mIU/mL)compared with the control group.Correlation analysis showed that ICVF in the left middle occipital gyrus and pontine crossing tract correlated positively with T3(r=0.268 and 0.321 respectively),while ICVF in the left cuneus and left superior occipital gyrus correlated with cortisol(r=0.278 and 0.268 respectively).CONCLUSION Prolonged night-shift causes CRD via neurostructural remodeling,endocrine dysregulation,neuroinflammation;hypothalamic-pituitary-thyroid/hypothalamic-pituitary-gonadal axis dysfunction mediates neuroimmune crosstalk.Multimodal biomarkers enable precise diagnosis/intervention. 展开更多
关键词 Inflammatory factors Endocrine Neuroimaging Diffusion spectrum imaging Circadian rhythm disruption
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Acidic Lycium barbarum polysaccharide as a promising candidate for preventing osteosarcopenia 认领 引用
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作者 Anni Yao Xiaofei Liang +10 位作者 Zhengfei Wang Daoping Sha Xinlan Zhang Mengqiu Liu Liqiang Zhao Yanan Liu Sheng Guo Fang Zhang Chunjie Bao Jialun Duan Jin'ao Duan 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第6期2759-2775,共17页
As the global population ages,the prevalence of osteosarcopenia—a combined condition of osteoporosis and sarcopenia—poses significant health challenges,leading to increased frailty,falls,and chronic disability in th... As the global population ages,the prevalence of osteosarcopenia—a combined condition of osteoporosis and sarcopenia—poses significant health challenges,leading to increased frailty,falls,and chronic disability in the elderly,especially for postmenopausal women.Nutritional interventions targeting age-associated physiological decline present promising strategies for managing these conditions.In this study,the preventive effects of total Lycium barbarum polysaccharide(LBP),acidic LBP(ALBP),and neutral LBP(NLBP)on osteosarcopenia were systematically evaluated using an ovariectomized(OVX)mouse model.Our findings showed that ALBP significantly improved physical performance,bone strength,and bone density,while enhancing muscle mass and fiber size,thereby effectively alleviating osteosarcopenia.Mechanistic investigations revealed that ALBP elevated the expression levels of osteoblast-associated genes such as Alp,Col1a1,Runx2,Opn,upregulated key myogenic genes,including Myh2,Myh4,Myh7,while activating the phosphoinositide 3 kinase-protein kinase B(PI3K-AKT)signaling pathway.Dose-response relationship studies confirmed the efficacy of ALBP in preventing osteosarcopenia.Further analysis using gut microbiota sequencing,depletion models,and correlation analysis demonstrated that the preventive effects of ALBP are strongly correlated with the gut microbiota,including Bacteroidota,Firmicutes,Desulfobacterota,and Patescibacteria.These results highlight the potential of ALBP as a promising candidate for preventing osteosarcopenia and improving the well-being of the elderly. 展开更多
关键词 Acidic Lycium barbarum polysaccharide Osteosarcopenia Functional food Aging related chronic diseases Ovariectomized(OVX)mice model
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1990~2021年中国心肌炎的疾病负担、趋势及性别差异 认领 引用
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作者 方章 罗晓钫 +1 位作者 张宇辉 张健 《中国循环杂志》 CSCD 北大核心 2026年第1期48-54,共7页
目的:分析1990~2021年中国心肌炎的疾病负担、趋势和性别差异。方法:基于全球疾病负担研究2021,收集1990~2021年中国(不包含台湾地区)的心肌炎数据,按照年龄和性别分析患病、发病、死亡例数和伤残调整寿命年(DALY)的疾病负担及其估计年... 目的:分析1990~2021年中国心肌炎的疾病负担、趋势和性别差异。方法:基于全球疾病负担研究2021,收集1990~2021年中国(不包含台湾地区)的心肌炎数据,按照年龄和性别分析患病、发病、死亡例数和伤残调整寿命年(DALY)的疾病负担及其估计年度百分比变化(EAPC)。应用Joinpoint回归分析1990~2021年心肌炎疾病负担的分段时间趋势并得出疾病负担的平均年度百分比变化(AAPC)。应用分解分析解释疾病负担变化的因素构成。采用贝叶斯年龄-时期-队列(BAPC)模型描述至2035年的心肌炎疾病负担趋势。结果:1990~2021年中国心肌炎的患病率、发病率、死亡率和DALY率的EAPC分别为1.22%(95%CI:1.13%~1.30%)、0.62%(95%CI:0.57%~0.67%)、1.09%(95%CI:0.89%~1.30%)、-1.72%(95%CI:-1.82%~-1.61%)。心肌炎的患病率、发病率及死亡率逐渐上升,DALY率呈下降趋势,其中男性和女性疾病负担变化趋势与总人群相同。2021年中国心肌炎的患病率、发病率及死亡率较1990年增幅分别为38.5%、23.4%和40.8%,DALY率降幅达39.1%。Joinpoint回归分析将1990~2021年中国心肌炎疾病负担指标的变化分为各自的4个时间段,结果显示,患病率、发病率、死亡率和DALY率的AAPC分别为1.078%(95%CI:0.993%~1.163%)、0.676%(95%CI:0.661%~0.691%)、1.127%(95%CI:0.848%~1.405%)和-1.532%(95%CI:-1.733%~-1.332%)。1990年和2021年,整体和大部分年龄段人群中男性心肌炎的患病、发病、死亡和DALY数量和率均高于女性。与1990年比,2021年<5岁年龄段人群患病、死亡和DALY数量明显减小但疾病负担仍高。各疾病负担数量的主体人群均向高年龄段移动,在65岁以上人群中显著增加。患病和DALY数量的变化主要由流行病学因素导致,而发病和死亡数量的变化主要由老龄化引起。基于BAPC模型预测,至2035年,中国心肌炎的年龄标准化患病率将持续上升,而其余疾病负担指标将下降。结论:中国(不包含台湾地区)心肌炎疾病负担总体控制有效。男性的心肌炎疾病负担高于女性。未来疾病负担的预防和管理需要更关注男性及老年人群。 展开更多
关键词 心肌炎 负担 趋势 性别差异
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心力衰竭患者应用袢利尿剂的不良反应与临床管理 认领 引用
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作者 方章 张健 《中国循环杂志》 CSCD 北大核心 2026年第3期291-296,共6页
袢利尿剂是治疗心力衰竭最基本的药物之一,但在应用时可能引起一系列不良反应,如电解质紊乱、肾功能恶化、神经内分泌系统的激活、延时指南指导的药物治疗等,大剂量袢利尿剂还具有潜在不良预后作用,这些均给袢利尿剂的临床应用带来了担... 袢利尿剂是治疗心力衰竭最基本的药物之一,但在应用时可能引起一系列不良反应,如电解质紊乱、肾功能恶化、神经内分泌系统的激活、延时指南指导的药物治疗等,大剂量袢利尿剂还具有潜在不良预后作用,这些均给袢利尿剂的临床应用带来了担忧与挑战。本文就袢利尿剂的常见不良反应以及其在心力衰竭患者中的管理进行了综述和讨论,以期为临床心力衰竭患者袢利尿剂的使用策略提供见解。 展开更多
关键词 心力衰竭 袢利尿剂 不良反应 临床管理
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Characteristics of the anti-dementia drug system of Zisu Fang preparations based on pharmacokinetic and pharmacodynamic analysis 认领 引用
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作者 Jianye Quan Shujuan Yang +5 位作者 Fang Zhang Li Tan Jing Kong Yanyan Jiang Rendi Sun Renbing Shi 《Journal of Traditional Chinese Medical Sciences》 CAS 2017年第2期207-215,共9页
Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu Fang preparations and additionally analysis the anti-dementia drug system characteristics.Methods:A PK-PD-drug i... Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu Fang preparations and additionally analysis the anti-dementia drug system characteristics.Methods:A PK-PD-drug interaction (DI) method was applied to determine the characteristics of index components of Zisu Fong preparations in vivo.Results:In the PK study,maximum plasma concentration,area under the plasma concentration-time curve,and mean residence time of index components of Zisu Fang preparations were higher in the memory-deficit model group than in the control group.This suggested that the index components of Zisu Fang preparations had an affinity for the state of dementia in this model.In the PD study,at the peak time points of anti-dementia efficacy (0.17 h and 1 h),the plasma concentrations of index components of Zisu Fang preparations reached the first or second largest plasma concentration peak or were close to the plasma concentration peak,and showed positive correlation between these two peaks,indicating that the index components of Zisu Fang synergistically exerted an anti-dementia effect.According to the association analysis of PK-PD-DI,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA were the main active ingredients of the anti-dementia drug system of Zisu Fang preparations in vivo,but were only efficacious against dementia when all five components were present at a specific concentration and proportion.Conclusions:Based on the PK and PD correlation analysis,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA are the main active ingredients of Zisu Fang preparations with regard to its anti-dementia effects,and represent the basic characteristics of drug system:natures,synergy,and affinity. 展开更多
关键词 Index components Pharmacokinetics Pharmacodynamics Characteristics of anti-dementia drug system
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Reproductive cycle of Ophiopholis mirabilis (Echinodermata: Ophiuroidea) in Zhangzi Island area, northern Yellow Sea 认领 引用
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作者 Nan YU Song SUN +1 位作者 Guangtao ZHANG Fang ZHANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2021年第1期173-184,共12页
Ophiopholis mirabilis is a common species with a high population density on the western coasts of the northern Pacifi c Ocean.The number of O.mirabilis has been increasing recently in the scallop aquaculture zone(the ... Ophiopholis mirabilis is a common species with a high population density on the western coasts of the northern Pacifi c Ocean.The number of O.mirabilis has been increasing recently in the scallop aquaculture zone(the Zhangzi Island area,northern Yellow Sea)in China.To explore the mechanism of its population variation,the reproductive cycle of O.mirabilis was investigated in this area(39°04′N;122°51′E)from February 2017 through January 2018 and determined by the monthly gonad index(GI),histological examinations of the gonads and the oocyte size-frequency distribution.O.mirabilis had a clear annual reproductive cycle that was synchronous between males and females.Sea temperature and food availability played important roles in O.mirabilis reproduction.The GI value was less reliable for determining reproductive activity in O.mirabilis because the nutritive tissues within the gonads may be utilized to synthesize gametes,leading to a decrease in GI during maturation.The histological results also show that abundant nutritive phagocytes were present in the gonads of O.mirabilis,which,together with the germ cells,aff ected the weight of the gonads.In addition,the mature oocytes of O.mirabilis were relatively small(75–150μm),indicating that the larval development was planktotrophic.This study provided insights into the reproductive patterns and biology of O.mirabilis and is an essential basis for the quantity control of this species in aquaculture areas. 展开更多
关键词 reproductive biology Ophiuroidea the northern Pacifi c Ocean Ophiopholis mirabilis
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Latent profilesof ambivalence over emotional expression in young breast cancer patients:A cross-sectional study 认领 引用 被引量：2
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作者 Xiaocen Chen Zhao Wang +3 位作者 Sibo Wang Fang Zhang Xueyu Li Jing Zhao 《International Journal of Nursing Sciences》 CSCD 2025年第4期379-385,I0004,I0005,共7页
Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods... Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods:A total of 217 young breast cancer patients were enrolled from a tertiary Grade A oncology hospital in Tianjin,China,using the convenience sampling method.All participants completed the general questionnaire,Ambivalence over Emotion Expression Questionnaire(AEQ),and Family Adapt-Ability and Cohesion Evaluation Scales-Chinese Version(FACES-CV).We employed exploratory latent profileanalysis for ambivalence over emotional expression profilingand logistic regression analysis to identify the influentialfactors Results:The results of the latent profileanalysis supported the models of four latent profiles,which were definedas“low conflict-lowexpression reflection”(19.2%),“high conflict-high inhibition expression”(43.9%),“moderate conflict-highregret expression”(18.1%),and“moderate conflict-desire understand”(18.8%).Logistic regression revealed that family cohesion,marital status,residence,per capita monthly income,and cancer stage were the influencingfactors of ambivalence over emotional expression in young breast cancer patients(P<0.05)Conclusions:Levels of ambivalence over emotional expression ameast cancer patients with breast cancer were highly heterogeneous.Medical staff should provide psychological counseling and health education tailored to the unique characteristics of emotional expression ambivalence in different patient groups to promote healthy emotional expression among patients. 展开更多
关键词 Ambivalence Breast neoplasms Cross-sectional studies Emotions Nursing Young adult
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A new strategy of molecular breeding for optimal heading date and grain yield in rice by modulating elite allelic combinations of Ghd7,Hd3a,RFT1 and Gn1a 认领 引用 被引量：1
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作者 Qingmei Su Rongsheng Wang +9 位作者 Xiaomin Feng Mengyue Zhao Guanlin Zhu Qing Wang Fang Zhang Shaoyang Lin Yuhang Zhang Li Zhu Qian Qian Fan Chen 《The Crop Journal》 SCIE CAS CSCD 2025年第2期490-500,共11页
A later heading date generally leads to higher grain yield in favorable ecological regions;however,grain yield reaches a limit as the heading date exceeds a certain threshold.Ghd7 is the first cloned major gene that r... A later heading date generally leads to higher grain yield in favorable ecological regions;however,grain yield reaches a limit as the heading date exceeds a certain threshold.Ghd7 is the first cloned major gene that regulates heading date,plant height and grain number.Here,we investigated the relationship between Ghd7 and florigen genes Hd3a and RFT1,to determine their roles in regulating heading date and grain number under different photoperiods.Our results revealed that under long-day(LD)conditions,Hd3a acts prior to RFT1 to promote heading while negatively regulating plant height and grain number.In contrast,Ghd7 positively regulates heading date,plant height,and grain number by inhibiting both Hd3a and RFT1.Under short-day(SD)conditions,the functions of Hd3a and RFT1 remain consistent with those under LD conditions,but Ghd7 does not inhibit their expression,resulting in a weaker phenotypic effect compared to Hd3a.Additionally,under both LD and SD conditions,increased Ghd7 expression enhances its inhibitory effect on Hd3a and RFT1,leading to later heading and increased grain number;however,once the heading date exceeds 94 d,grain number no longer increases.Moreover,the gn1a allele increased grain number by 16.5%to 42.5%,while combinations of the elite alleles from Ghd7,Hd3a,RFT1,and Gn1a significantly increased grain number by up to 240.9%.Therefore,we propose a new breeding strategy to optimize the heading date and grain number using the Ghd7Hd3aRFT1gn1a combination of Ghd7,Hd3a,RFT1,and Gn1a under LD conditions,and the Ghd7hd3aRFT1gn1a combination under SD conditions.This strategy improved the yield of the high-quality Northeast variety Kongyu 131(KY131)by 69.1%in Beijing and 93.7%in Hainan.This strategy will greatly improve the efficiency of north-to-south adaptation in rice,providing theoretical guidance for expanding the geographical adaptability of rice varieties. 展开更多
关键词 Adaptation Elite gene combinations Oryza sativa Photoperiod response
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Elucidating the therapeutic potential of Maimendong decoction in pulmonary fibrosis:A molecular perspective 认领 引用 被引量：1
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作者 Shuangshuang He Lan Zhang +7 位作者 Fang Zhang Yuanrong Wang Kai Wang Shanshan Guo Yuqi Wang Wenqing Dong Min Fu Yu Li 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第2期231-245,共15页
Objective:To identify the active components in Maimendong decoction(MMDD)against pulmonary fibrosis(PF)and validate their molecular effects in vitro,while focusing on the role of methyl-ophiopogonanone B in regulating... Objective:To identify the active components in Maimendong decoction(MMDD)against pulmonary fibrosis(PF)and validate their molecular effects in vitro,while focusing on the role of methyl-ophiopogonanone B in regulating fibrosis.Methods:Data on MMDD components and targets were gathered from databases including BATMAN-TCM and PubMed,whereas the PF gene data were sourced from GeneCards,OMIM,and TTD.Shared targets were determined using the STRING database,and molecular docking was used to analyze the essential molecules associated with fibrosis.To simulate PF conditions,human embryonic lung fibro-blasts(HPF)and A549 cells were exposed to transforming growth factor-β1(TGF-β1).Various assays were used to determine the effects of MMDD and methylophiopogonanone B on signaling pathways,apoptosis,and epithelialemesenchymal transition.Results:We identified 11 active components from MMDD extracts that targeted 511 shared proteins associated with PF,revealing 10 key targets in network analysis.Gene ontology analysis indicated that processes and pathways such as apoptosis regulation and PI3K/Akt signaling were involved.In vitro experiments revealed that MMDD downregulated the expression ofα-smooth muscle actin(a-SMA),collagen typeⅠ(COL-Ⅰ),and collagen typeⅢand regulated Bcl-2/Bax signaling pathways to promote apoptosis.The flow cytometry apoptosis assay revealed that MMDD promoted the TGF-β1-induced apoptosis of myofibroblasts.The primary active ingredient in MMDD,methylophiopogonanone B,reducedα-SMA,COL-Ⅰ,and PI3K/Akt/mTOR-related protein levels in TGF-β1-treated HPF cells,decreased Bcl-2 and cleaved caspase 3,and increased Bax.Moreover,methylophiopogonanone B increased E-cadherin levels and reducedα-SMA,fibronectin,N-cadherin,vimentin,and snail in TGF-b1-treated A549 cells.Conclusion:Methylophiopogonanone B demonstrated the potential to treat PF by inducing myofibroblast apoptosis and inhibiting EMT.However,despite encouraging initial results,further clinical research is warranted to verify the safety and efficacy of methylophiopogonanone B in the management of PF. 展开更多
关键词 Pulmonary fibrosis Methylophiopogonanone B HPF cell A549 cell EMT Apoptosis
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Effect of moxibustion on P2X7R/NF-κB pathway in ulcerative colitis rats with repeated induction of DSS 认领 引用
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作者 Zhe Ma Lingjie Li +11 位作者 Huangan Wu Jianhua Zhou Yaying Lin Yu Qiao Shiyu Zheng Ling Yang Yan Huang Yanan Liu Fang Zhang Lu Zhu Qin Qi Luyi Wu 《Acupuncture and Herbal Medicine》 CAS CSCD 2025年第2期205-216,共12页
Objective:To investigate the mechanism by which moxibustion regulates the expression of inflammatory cytokines in ulcerative colitis(UC)rats through the P2X7 receptor(P2X7R)uclear factor-kappa B(NF-κB)pathway.Methods... Objective:To investigate the mechanism by which moxibustion regulates the expression of inflammatory cytokines in ulcerative colitis(UC)rats through the P2X7 receptor(P2X7R)uclear factor-kappa B(NF-κB)pathway.Methods:UC was induced using dextran sulfate sodium(DSS)in both wild-type(WT)and P2X7R knockout(KO)mice.General health conditions,pathological changes,and periodic acid-Schiff(PAS)staining of the colonic tissues were analyzed.Immunohistochemistry was used to detect NF-κB p65 protein expression in colonic tissues.Male Sprague-Dawley(SD)rats were randomly assigned to four groups:normal,model,normal+herb-partitioned moxibustion,and model+herb-partitioned moxibustion.UC was induced in rats by cyclic DSS administration.Rats in the herb-partitioned moxibustion group received moxibustion at the bilateral Tianshu(ST25)and Qihai(RN6)acupoints.The effects of herb-partitioned moxibustion were evaluated regarding general health conditions and histopathological alterations in colon tissue.The protein expression of P2X7R and NF-κB p65 in colonic tissues was determined by immunohistochemistry,whereas interleukin(IL)-10 mRNA levels were quantified using real-time quantitative polymerase chain reaction(RT-qPCR).Furthermore,enzyme-linked immunosorbent assay(ELISA)was used to measure serum concentrations of tumor necrosis factor-alpha(TNF-α)and IL-6.Results:Colonic epithelial damage and inflammatory cell infiltration were significantly reduced in P2X7R KO mice compared to WT mice,along with reduced expression of NF-κB p65 protein in colonic tissues(P<0.05).Moxibustion improves histopathological damage,goblet cell number,and intestinal mucus secretion in rats with UC.Compared to the normal group,the model group exhibited increased histopathological scores,serum TNF-α,and IL-6 levels,as well as elevated P2X7R and NF-κB p65 protein expression in colonic tissues(P<0.05).In comparison to the model group,the model+herb-partitioned moxibustion group demonstrated significantly lower histopathological scores,reduced serum TNF-αand IL-6 levels,and decreased P2X7R and NF-κB p65 protein expression(P<0.05).Conclusions:Moxibustion at“Tianshu”and“Qihai”acupoints may inhibit the levels of IL-6 and TNF-αinflammatory factors and reduce inflammation in the UC colonic mucosa by regulating the P2X7R/NF-κB p65 pathway in UC colonic tissues. 展开更多
关键词 Immunomodulation Moxibustion NF-κB p65 P2X7R Ulcerative colitis
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Evaluation of MgO on hematite swelling dynamics during CO-driven stepwise reduction 认领 引用
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作者 Fang Zhang Jun Peng +2 位作者 Shuang Liu Yong-bin Wang Fan Yang 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第3期564-577,共14页
The significant effect of MgO in inhibiting the reduction swelling of iron ore pellets has been widely recognized.The swelling behaviors of pellets during the stepwise reduction by CO were assessed.The linear expansio... The significant effect of MgO in inhibiting the reduction swelling of iron ore pellets has been widely recognized.The swelling behaviors of pellets during the stepwise reduction by CO were assessed.The linear expansion of strip samples was measured using a linear dilatometer during the staged reduction process at a temperature of 900℃.The existence states of MgO in hematite,magnetite,and wüstite were investigated through thermodynamic calculations.The magnetite strip samples were subjected to oxidizing roasting at 1250℃ for 30 min to produce hematite strip samples.The strip samples with 0.49,1.49,2.49,and 3.49 wt.%MgO were analyzed for length change.It was observed that the sample with 2.49 wt.%MgO exhibited the least significant length change.The lengths of the samples with the initial length being 20 mm before reduction changed during the reduction stages of Fe2O3→Fe3O4,Fe3O4→FeO,and FeO→Fe were 615,−25,and−378μm,respectively.The volume expansion of hematite to magnetite was primarily attributed to the crystal transformation.During the reduction stage from wüstite to metallic iron,a substantial contraction occurred,while the slag phase was able to retain its original basic shape.The enclosed areas,as indicated by the expansion change curves of the samples with 0.49,1.49,2.49,and 3.49 wt.%MgO,were measured at 3.76×106,3.23×106,3.05×106,and 3.17×106μm s,respectively. 展开更多
关键词 MgO Hematite Reduction swelling Step-by-step reduction
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Longitudinal velocity control of autonomous driving based on extended state observer 认领 引用
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作者 Hongbo Gao Hanqing Yang +11 位作者 Xiaoyu Zhang Xiangyun Ren Fenghua Liang Ruidong Yan Qingchao Liu Mingmao Hu Fang Zhang Jiabing Gao Siyu Bao Keqiang Li Deyi Li Danwei Wang 《CAAI Transactions on Intelligence Technology》 SCIE EI CSCD 2025年第1期36-46,共11页
Active Disturbance Rejection Control(ADRC)possesses robust disturbance rejection capabilities,making it well-suited for longitudinal velocity control.However,the conventional Extended State Observer(ESO)in ADRC fails ... Active Disturbance Rejection Control(ADRC)possesses robust disturbance rejection capabilities,making it well-suited for longitudinal velocity control.However,the conventional Extended State Observer(ESO)in ADRC fails to fully exploit feedback from first-order and higher-order estimation errors and tracking error simultaneously,thereby diminishing the control performance of ADRC.To address this limitation,an enhanced car-following algorithm utilising ADRC is proposed,which integrates the improved ESO with a feedback controller.In comparison to the conventional ESO,the enhanced version effectively utilises multi-order estimation and tracking errors.Specifically,it enhances convergence rates by incorporating feedback from higher-order estimation errors and ensures the estimated value converges to the reference value by utilising tracking error feedback.The improved ESO significantly enhances the disturbance rejection performance of ADRC.Finally,the effectiveness of the proposed algorithm is validated through the Lyapunov approach and experiments. 展开更多
关键词 active disturbance rejection control(ADRC) autonomous vehicle extended state observer(ESO) intelligent control longitudinal velocity control
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Zooplankton community composition in summers of 2021and 2022 in the northern East China Sea and Yellow Sea,and their linkage with abiotic and biotic factors 认领 引用
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作者 Dongjie GUO Fang ZHANG +1 位作者 Shuangyan ZHANG Song SUN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2025年第1期159-176,共18页
The northern East China Sea and Yellow Sea are highly dynamic marginal seas,serving as important fishing grounds and primary areas for aquaculture.The zooplankton community structure,including abundance,biovolume,and ... The northern East China Sea and Yellow Sea are highly dynamic marginal seas,serving as important fishing grounds and primary areas for aquaculture.The zooplankton community structure,including abundance,biovolume,and normalized biovolume size spectra(NBSS)within this ecosystem in summers 2021 and 2022 was assessed through ZooScan digital imaging system.The abundances of zooplankton in summers 2021 and 2022 were 3364.22±2190.53 and 4435.52±2520.06 inds./m3,respectively,whereas the corresponding biovolumes were 649.10±519.63 and 1064.86±1254.87 mm3/m3,respectively.Small copepods as the dominant zooplankton functional group in terms of abundance in both years,while chaetognath and medusae were the dominant groups in terms of biovolume.The dominance of medusae and chaetognath in terms of biovolume,along with the flatter slopes of NBSS compared to a stable community,indicated that more energy accumulated in gelatinous organisms within the study area.There were significant positive relationships between temperature and tunicates or medusae,with a significantly higher population size observed in summer 2022 than in 2021.The lower abundance and biovolume of zooplankton,mainly of small copepods,in summer 2021 may be related to the larger population size of the large jellyfish and the proliferation of green tides.The investigation provided basic data and fundamental insights for achieving a comprehensive understanding of zooplankton community structure and their long-term dynamics. 展开更多
关键词 zooplankton community spatial distribution global warming Nemopilema nomurai Ulva prolifera
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