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Gut microbiota:a potential target for hyperuricemia and gout 认领 引用
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作者 Feiyan Zhao Shuying Yang +3 位作者 Lai-Yu Kwok Hongbin Li Heping Zhang Zhihong Sun 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第9期3333-3345,共13页
Modern lifestyle and diet have increased the incidence rate of uric acid(UA)metabolism-related diseases like hyperuricemia(HUA)and gout,posing heavy economic burden to individual patients and their families and the so... Modern lifestyle and diet have increased the incidence rate of uric acid(UA)metabolism-related diseases like hyperuricemia(HUA)and gout,posing heavy economic burden to individual patients and their families and the society.UA metabolism is a complex physiological process involving the kidney,intestine,and other organs.A number of factors together regulate UA metabolism,including genetics,diet,hormones,and the gut microbiota.This review summaries the gut microbiota features in subjects with HUA and gout,and the therapeutic effects of implementing microecological therapies(probiotics,prebiotics,or fecal microbiota transplant)that target modulate the gut microbiota and its downstream metabolism on the disease.Current evidence shows that these strategies are safe and promising in alleviate inflammation,reduce UA,and restoring a healthy gut microbiota in subjects with UA metabolism-related diseases.However,most clinical data are generated by animal studies.Therefore,we propose that vigorous human intervention trials should be conducted in the future to evaluate the therapeutic effects of microecological therapies in managing HUA and gout. 展开更多
关键词 Hyperuricemia Gout Uric acid Gut microbiota Probiotic Prebiotic
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益生菌Lactobacillus paracasei subsp. paracasei Zhang对海南地区部分青年人肠道菌群的影响 认领 引用 被引量：2
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作者 沈玲玲 徐海燕 +5 位作者 侯强川 赵飞燕 刘亚华 王佼 孙志宏 张和平 《微生物学报》 CAS CSCD 北大核心 2020年第10期2184-2197,共14页
【目的】以海南地区征集的29名健康青年志愿者为研究对象,分析该地区青年人肠道菌群多样性,并探究益生菌Lactobacillus paracasei subsp. paracasei Zhang (LCZ)对其肠道菌群的影响。【方法】29名健康青年志愿者每日补充2 g益生菌LCZ (0... 【目的】以海南地区征集的29名健康青年志愿者为研究对象,分析该地区青年人肠道菌群多样性,并探究益生菌Lactobacillus paracasei subsp. paracasei Zhang (LCZ)对其肠道菌群的影响。【方法】29名健康青年志愿者每日补充2 g益生菌LCZ (0.5×10^10CFU/g),为期14 d。采集摄入益生菌LCZ第0、14、28天的志愿者粪便样品,采用Pac Bio SMRT测序技术基于16S rRNA基因全长测序分析志愿者粪便微生物组成和结构,评估益生菌LCZ对其肠道菌群的影响。【结果】在门水平上,Firmicutes (54.46%)和Bacteroidetes (33.79%)在志愿者粪便微生物中含量最高;在属水平上,Bacteroides (23.13%)的相对含量最高;在种水平上,优势菌种为Faecalibacterium prausnitzii (9.72%)、Eubacterium rectale (7.00%)和Prevotella copri (6.07%)等。摄入益生菌LCZ 14 d后,肠道中的优势菌属变化不显著,低丰度菌属如Oscillospira和Parabacteroides等显著增加,Aeromonas和Fusicatenibacter等显著减少(P<0.05)。此外根据志愿者粪便中Lactobacillus含量的变化情况,将所有志愿者分为两组。其中一组志愿者在摄入LCZ后粪便中Lactobacillus菌属相对含量显著增加,同时该组志愿者肠道中其他菌种如Butyricicoccus pullicaecorum、Lactococcus raffinolactis和Parabacteroides distasoni亦显著增加;而另一组志愿者,Lactobacillus及上述菌种均未发生显著变化。【结论】连续2周摄入益生菌LCZ对志愿者肠道菌群中优势菌属的相对丰度影响不显著,但对低丰度菌属的相对丰度影响显著。 展开更多
关键词 海南地区青年人群 肠道菌群 细菌多样性 Lactobacillus paracasei subsp.paracasei Zhang
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Lentiviral vectors for gene therapy of α-thalassemia 认领 引用 被引量：3
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作者 Saijuan Xu Dan Liang +7 位作者 Yan Cheng Gongrui Sun Feiyan Zhao Yang Yang Haokun Zhang Yongrong Lai Bin Fu Yuxuan Wu 《Science China(Life Sciences)》 SCIE CAS CSCD 2025年第7期2177-2179,共3页
Dear Editor,Alpha-thalassemia(α-tha) is an inherited hemolytic disease with an increasing prevalence worldwide that is caused by a complete or partial absence of α-globin chain synthesis due to α-globin chain synth... Dear Editor,Alpha-thalassemia(α-tha) is an inherited hemolytic disease with an increasing prevalence worldwide that is caused by a complete or partial absence of α-globin chain synthesis due to α-globin chain synthesis disorders(Farashi and Harteveld,2018).Mild α-tha is generally considered untreatable,whereas transfusion-dependent and severe forms require lifelong transfusions,which can lead to chronic iron overload necessitating chelation therapy(Horvei et al.,2021;Baird et al.,2022). 展开更多
关键词 iron overload hemolytic disease chelation therapy horvei lentiviral vectors gene therapy inherited hemolytic disease alpha globin chain synthesis disorders alpha thalassemia
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肠道微生物间互作及其代谢物发挥作用的研究进展 认领 引用 被引量：7
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作者 赵飞燕 赵佳 +1 位作者 马蕊 孙志宏 《科学通报》 EI CAS CSCD 北大核心 2025年第1期83-95,共13页
肠道是一个完整的生态系统,不同微生物间通过中立、共生、竞争和捕食等方式形成了复杂的微生态关系网络,进而影响宿主的健康.正常情况下,肠道微生物间处于动态平衡的状态,当受到内部和/或外界因素影响后,肠道微生态也会发生相应的变化.... 肠道是一个完整的生态系统,不同微生物间通过中立、共生、竞争和捕食等方式形成了复杂的微生态关系网络,进而影响宿主的健康.正常情况下,肠道微生物间处于动态平衡的状态,当受到内部和/或外界因素影响后,肠道微生态也会发生相应的变化.值得注意的是,该变化不仅是单个微生物丰度的改变,更多的是该微生物互作关系网络内微生物群的变化,进而导致肠道微生物整体多样性、结构、功能和代谢物水平的改变.此外,菌群代谢物是肠道微生物与宿主互作的主要媒介,短链脂肪酸和胆汁酸等关键的菌群代谢物可与宿主直接对话,并在机体营养吸收、代谢、免疫系统发育和病原体防御等方面发挥着重要作用.因此,本文总结了肠道微生物间的互作关系,并讨论了肠道微生物通过产生关键代谢物与宿主互作的方式,为深入了解微生物间互作及其代谢物对宿主健康的潜在作用提供参考. 展开更多
关键词 肠道微生物 代谢物 互作关系 宿主健康
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Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study 认领 引用 被引量：4
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作者 Wan Tu Dongdong Ni +15 位作者 Hua Yang Feiyan Zhao Chen Yang Xuehan Zhao Zhiyuan Guo Kunyuan Yu Jingzi Wang Zhaoshan Hu Zixuan Chen Yan Zhao Zhenbo Wang Fei Gao Long Yan Xiaokui Yang Lan Zhu Hongmei Wang 《Science Bulletin》 SCIE EI CAS CSCD 2022年第18期1854-1859,M0003,共6页
Female reproduction and health are highly dependent on ovarian function.Ovarian reserve is a critical indicator of ovarian function[1].The ovarian reserve refers to the stock of dormant primordial follicles(primordial... Female reproduction and health are highly dependent on ovarian function.Ovarian reserve is a critical indicator of ovarian function[1].The ovarian reserve refers to the stock of dormant primordial follicles(primordial follicle pool)residing in the ovarian cortex[2].The primordial germ cells(PGCs)are enclosed by the basal lamina to form cyst at the beginning of ovarian development[3]. 展开更多
关键词 卵巢储备 雌激素缺乏 形态计量学 女性卵巢 心血管疾病 全生命周期 骨质疏松症 非人灵长类
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Changes in gut microbiota structure and function in gout patients 认领 引用 被引量：4
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作者 Feiyan Zhao Zhixin Zhao +4 位作者 Dafu Man Zhihong Sun Ning Tie Hongbin Li Heping Zhang 《Food Bioscience》 SCIE 2023年第4期640-648,共9页
Gout is a metabolic disease caused by hyperuricemia resulting from purine metabolism disorder.It mainly manifests as joint pain or inflammation caused by urate crystal deposition in joints.Some recent studies have rev... Gout is a metabolic disease caused by hyperuricemia resulting from purine metabolism disorder.It mainly manifests as joint pain or inflammation caused by urate crystal deposition in joints.Some recent studies have revealed the potential of gut microbiota in regulation of purine metabolism and body inflammation,suggesting gut microbiota can become the target for gout prevention and treatment.This study is a preliminary trial investigating the role of probiotics in the adjuvant treatment of gout and providing reference data for the selection of probiotics for use in further clinical trials.In total,40 male participants were recruited(gout=20,healthy controls=20).The characteristics of gut microbiota in gout patients and the relationship between gut microbiota and gout-related clinical indices were explored.The results showed(1)lower microbiota diversity and microecological disturbance in the gut of gout patients(P<0.001)(2)changes in gut microbiota(e.g.,Faecalibacterium prausnitzil,Bacteroides uniformis,Lachnospira eligens);affected several metabolic pathways,such as uric acid metabolism and purine metabolism,which may modify the levels of active metabolites such as cholate and cholesterol in the body;(3)strong correlations between key differential species and the uric acid level,and key differential species may be used as probes for detecting uric acid metabolism to treat and prevent gout.Overall,our research proved the crucial relationship between gut microbiota and gout,thereby providing direction and scientific guidance for next clinical trials. 展开更多
关键词 Gout Gut microbiota Uric acid Purine metabolism
The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows 认领 引用 被引量：36
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作者 Haiyan Xu Weiqiang Huang +6 位作者 Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang 《Science Bulletin》 SCIE EI CAS CSCD 2017年第11期767-774,共8页
Probiotics administration can improve host health. This study aims to determine the effects of probiotics （Lactobacillus casei Zhang and Lactobacillus plantarum P-8） administration on milk production, milk func- tio... Probiotics administration can improve host health. This study aims to determine the effects of probiotics （Lactobacillus casei Zhang and Lactobacillus plantarum P-8） administration on milk production, milk func- tional components, milk composition, and fecal microbiota of dairy cows. Variations in the fecal bacteria microbiota between treatments were assessed based on 16S rRNA profiles determined by PacBio single molecule real-time sequencing technology. The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin C （IgG）, lactoferrin （LTF）, lysozyme （LYS） and lactoperoxidase （LP）, while the somatic cell counts （SCC） significantly decreased （P〈0.01）. However, no significant difference was found in the milk fat, protein and lactose contents （P 〉 0.05）. Although the probiotics supplementation did not change the fecal bacteria richness and diversity, significantly more rumen fermentative bacteria （ Bacteroides, Roseburia, Ruminococcus, CIostridium, Coprococcus and Dorea） and beneficial bacteria （Faecalibacterium prausnitzii） were found in the probiotics treatment group. Meanwhile, some opportunistic pathogens e.g. Bacillus cereus, Cronobacter sakazakii and Alkaliphilus oremlandii, were suppressed. Additionally, we found some correlations between the milk production, milk components and fecal bacteria. To sum up, our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. 展开更多
关键词 Milk production Milk components Fecal bacteria Prnbintics Dairy cow PacBio single molecule real-time sequencing technology
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Spraying compound probiotics improves growth performance and immunity and modulates gut microbiota and blood metabolites of suckling piglets 认领 引用 被引量：17
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作者 Weiqiang Huang Teng Ma +8 位作者 Yiqun Liu Lai-Yu Kwok Yalin Li Hao Jin Feiyan Zhao Xin Shen Xuan Shi Zhihong Sun Heping Zhang 《Science China(Life Sciences)》 SCIE CAS CSCD 2023年第5期1092-1107,共16页
One factor that shapes the establishment of early neonatal intestinal microbiota is environmental microbial exposure,and probiotic application has been shown to promote health and growth of piglets.Thus,this study hyp... One factor that shapes the establishment of early neonatal intestinal microbiota is environmental microbial exposure,and probiotic application has been shown to promote health and growth of piglets.Thus,this study hypothesized that environmental probiotic application in early days of life would be beneficial to newborn piglets.This study aimed to investigate the effect of spraying a compound probiotic fermented liquid(CPFL)into the living environment of piglets on their early growth performance and immunity.This work included 68 piglets,which were randomized into probiotic and control groups.Blood and fecal samples were collected at 0,3,7,14,and 21 days of age.Spraying CPFL significantly reshaped the microbiota composition of the delivery room environment,increased piglets’daily weight gain and weaning weight(P<0.001),and modulated piglets’serum cytokine levels(increases in Ig A,Ig G,and IL-10;decrease in IFN-γ;P<0.05 in each case)in piglets.Additionally,spraying CPFL during early days of life modified piglets’gut microbiota structure and diversity,increased the abundance of some potentially beneficial bacteria(such as Bacteroides uniformis,Butyricimonas virosa,Parabacteroides distasonis,and Phascolarctobacterium succinatutens)and decreased the abundance of Escherichia coli(P<0.05).Interestingly,CPFL application also significantly enhanced the gut microbial bioactive potential and levels of several serum metabolites involved in the metabolism of vitamins(B2,B3,B6,and E),medium/long-chain fatty acids(caproic,tetradecanoic,and peptadecanoic acids),and dicarboxylic acids(azelaic and sebacic acids).Our study demonstrated that spraying CPFL significantly could improve piglets’growth performance and immunity,and the beneficial effects are associated with changes in the gut microbiota and host metabolism.Our study has provided novel data for future development of probiotic-based health-promoting strategies and expanded our knowledge of probiotic application in animal husbandry. 展开更多
关键词 compound probiotic fermented liquid gut microbiota immunity piglets serum metabolites
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Changes in chemical composition,structural and functional microbiome during alfalfa(Medicago sativa)ensilage with Lactobacillus plantarum PS-8 认领 引用 被引量：10
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作者 Lijun You Weichen Bao +6 位作者 Caiqing Yao Feiyan Zhao Hao Jin Weiqiang Huang Bohai Li Lai-Yu Kwok Wenjun Liu 《Animal Nutrition》 SCIE CAS CSCD 2022年第2期100-109,共10页
Improving silage production by adding exogenous microorganisms not only maximizes nutrient preservation,but also extends product shelf life.Herein,changes in the quality and quantity of Lactobacillus plantarum PS-8(PS... Improving silage production by adding exogenous microorganisms not only maximizes nutrient preservation,but also extends product shelf life.Herein,changes in the quality and quantity of Lactobacillus plantarum PS-8(PS-8)-inoculated alfalfa(Medicago sativa)during silage fermentation were monitored at d 0,7,14,and 28(inoculum dose of PS-8 was 1105 colony forming units[cfu]/g fresh weight;50 kg per bag;10 bags for each time point)by reconstructing metagenomic-assembled genomes(MAG)and Growth Rate InDex(GRiD).Our results showed that the exogenous starter bacterium,PS-8 inoculation,became the most dominating strain by d 7,and possibly played a highly active role throughout the fermentation process.The pH value of the silage decreased greatly,accompanied by the growth of acidproducing microorganisms namely PS-8,which inhibited the growth of harmful microorganisms like molds(4.18 vs.1.42 log cfu/g)and coliforms(4.95 vs.0.66 log most probable number[MPN]/g).The content of neutral detergent fiber(NDF)decreased significantly(41.6%vs.37.6%;dry matter basis).In addition,the abundance and diversity of genes coding microbial carbohydrate-active enzymes(CAZymes)increased significantly and desirably throughout the fermentation,particularly the genes responsible for degrading starch,arabino-xylan,and cellulose.Overall,our results showed that PS-8 was replicating rapidly and consistently during early-and mid-fermentation phases,promoting the growth of beneficial lactic acid bacteria and inhibiting undesirable microbes,ultimately improving the quality of silage. 展开更多
关键词 Lactobacillus plantarum PS-8 Alfalfa silage Lactic acid bacteria Microbiota community Metagenomic-assembled genome
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Biodiversity of intestinal Lactobacillus in relation to dietary habits and health status in Mongolians of China 认领 引用 被引量：2
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作者 Wen Fang Xin Su +7 位作者 Zhixin Zhao Haiting Duan Shuying Yang Feiyan Zhao Munkhtsetseg Ochirdanzan Enkhtsetseg Tserenkhuue Ganmaa Davaasambuu Bilige Menghe 《Food Bioscience》 SCIE 2024年第1期1126-1135,共10页
Diet and health status directly or indirectly affect the gut microbiota.Mongolians have a varied intestinal Lactobacillus.However,how the diet regulates intestinal Lactobacillus and affects health has not been fully d... Diet and health status directly or indirectly affect the gut microbiota.Mongolians have a varied intestinal Lactobacillus.However,how the diet regulates intestinal Lactobacillus and affects health has not been fully discussed.In this research,we engaged 72 adult Mongolian participants.Conducting a physical examination and Dietary assessments to understood their dietary habits and health status.Then,Designed a pair of Lactobacillus-specific primers to seeking correlations between their diet,health,and intestinal Lactobacillus.The results show that the Lactobacillus-specific primer(Lac16s)used was highly effective in amplifying Lactobacillus sequences.The amplified fragment effectively differentiated various Lactobacillus species.We deciphered the Lactobacillus diversity in Mongolian participants,discovering notable differences between the normal and overweight individuals.Specifically,the overweight group exhibited higher abundances of Ligilactobacillus salivarius,Limosilactobacillus mucosae,Ligilactobacillus ruminis,and Limosilactobacillus reuteri,whereas the normal weight group had a pronounced presence of Lacticaseibacillus paracasei.A deeper analysis established that vitamin intake profoundly influences the Lactobacillus composition in Mongolian intestines.Additionally,the health of the participants was closely tied to the presence of Lacticaseibacillus paracasei and Limosilactobacillus mucosae.Scrutinizing the relationships between Lactobacillus strains and metabolic function revealed a significant link between most metabolic pathways,such as ascorbate and aldarate metabolism,fructose and mannose metabolism,and histidine metabolism,especially with Lacticaseibacillus paracasei.This strain may be influenced by dietary habits.In conclusion,we infer that the Lactobacillus composition in Mongolian intestines is intertwined with their diet and health. 展开更多
关键词 Intestinal Lactobacillus Mongolian population Dietary habits Health status Primers
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