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A telomere-to-telomere genome assembly of radish(Raphanus sativus L.)provides insights into QTL mapping of bolting traits 认领 引用 被引量：1
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作者 Feng Yang Sihan Peng +13 位作者 Shuai Yuan Maolin Ran Xiaomei Li Yuejian Li Bin Liu Ming Li Chuibao Kong Xiao Yang Guohui Pan Xiaoping Yong Ke Ran Na Kuang Dawei Zhang Honghui Lin 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第2期305-320,共16页
Radish(Raphanus sativus L.)is an important cruciferous root vegetable,with bolting regulated by multiple genes.However,the genetic mechanisms underlying bolting regulation remain unclear.Here,the genome of the cultiva... Radish(Raphanus sativus L.)is an important cruciferous root vegetable,with bolting regulated by multiple genes.However,the genetic mechanisms underlying bolting regulation remain unclear.Here,the genome of the cultivar C60213 is assembled into a high-quality,gap-free telomere-to-telomere structure,spanning nine chromosomes and totaling 472.71 Mb,using a combination of Oxford Nanopore,PacBio,and Hi-C sequencing technologies.It identifies 49,768 protein-coding genes,97.38%of which are functionally annotated.Repetitive sequences constitute 59.72%of the genome,primarily comprising long terminal repeats.A high-density genetic linkage map is constructed using an F2 population derived from a cross between early-and late-bolting radishes,identifying seven major quantitative trait loci associated with bolting and flowering.RNA-seq and quantitative real-time PCR analysis reveal that the RsMIPS3 gene is found to be associated with bolting,with its expression decreasing during this process.Notably,RsMIPS3 overexpression in Arabidopsis delays bolting,confirming its role in regulating bolting time.These findings advance radish genome research and provide a valuable target for breeding late-bolting varieties. 展开更多
关键词 Raphanus sativus L. Telomere-to-telomere Genome QTL Late-bolting RsMIPS3
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Optimizing nitrogen application increases strip-intercropped maize yields by reshaping root morphology and physiology 认领 引用
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作者 Liang Feng Xuyang Zhao +10 位作者 Xin Liu Sumaira Manzoor Zhenying Tao Shaorun Zhang Guangxi Li Tian Pu Yushan Wu Taiwen Yong Feng Yang Xiaochun Wang Wenyu Yang 《The Crop Journal》 SCIE CSCD 2026年第2期639-649,共11页
The objective of this study was to identify a combination of N application site and application rate that maximized maize yield and nutrient efficiency in soybean-maize strip intercropping systems in southwest China.A... The objective of this study was to identify a combination of N application site and application rate that maximized maize yield and nutrient efficiency in soybean-maize strip intercropping systems in southwest China.A two-year,two-factor split-plot experiment was performed,with the N application site(S)and N application rate(N)as the primary factor and the sub-factor,respectively.S1 represents narrow row N application site,while S2,S3,and S4 represent wide row N application site at distances of 10 cm,20 cm,and 30 cm from the maize plants,respectively.N0 represents 0 kg N ha-1,while N1,N2,and N3 represent 225 kg N ha-1,300 kg N ha-1,and 375 kg N ha-1,respectively.Results indicated that S3N2 significantly increased maize yield by 19.77%and system yield by 16.92%relative to S1N2.This yield advantage was mainly attributed to increased biomass allocation to ears rather than stems or leaves.Compared with S1N2,S3N2 significantly increased the root dry weight(RDW)in 020 cm layer by 95.02%,and root length(RL),root volume(RV),and root surface area(RSA)in 3050 cm layer by 42.76%,28.82%,and 26.67%,respectively.Additionally,compared with S1N2,S3N2 significantly increased root sap rate,ammonium N,nitrate N,and root N metabolism enzymes activity,ultimately increasing N harvest index.Interactions between N application site and N application rate significantly increased RDW,RL,RV,RSA,root physiological activity,and improved nutrient use efficiency and strip-intercropped maize yield.In summary,S3N2 is recommended as the N management strategy for soybean-maize strip intercropping systems,as it can achieve the win-win goals of increasing maize yield and improving nutrient efficiency. 展开更多
关键词 Nitrogen Maize Intercropping system Root Nutrient use efficiency
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A review on the biomedical Ti-Cu alloys:Design,preparation,microstructure and properties 认领 引用
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作者 Kunmao Li Shengfeng Zhou +2 位作者 Jing Liu Feng Yang Chengliang Yang 《Metals Advances》 SCIE EI CAS CSCD 2026年第1期47-67,共21页
In clinical fields with a high risk of infection,such as orthopedics and dentistry,stringent requirements are imposed on the mechanical properties,biocompatibility,and antibacterial performance of biomedical materials... In clinical fields with a high risk of infection,such as orthopedics and dentistry,stringent requirements are imposed on the mechanical properties,biocompatibility,and antibacterial performance of biomedical materials.As an emerging functional biomedical alloy,Titanium-copper(Ti-Cu)alloys have received increasing attention due to their unique composition and microstructure,which endow these materials with favorable mechanical strength,biological activity,and long-lasting antibacterial functionality.However,a systematic summary of the existing research findings remains lacking.In this review,the classification and fundamental properties of Ti-Cu alloys are first outlined.Recent progress in design strategies,fabrication techniques,microstructural characteristics,mechanical behavior,wear resistance,corrosion performance,and biological properties is comprehensively reviewed.Special emphasis is placed on the dual forms of Cu(solid solution Cu and Ti2Cu phase)and their synergistic effects on both mechanical and biological performance.The antibacterial mechanisms and biosafety of Cu are specifically summarized,and its antibacterial efficacy and tissue compatibility are evaluated based on in vitro studies and animal models.Based on these findings,the key challenges associated with the practical application of Ti-Cu alloys are analyzed,and potential directions for optimization and future development are proposed.The review concludes with a concise summary and several forward-looking perspectives. 展开更多
关键词 Biomedical material Ti-Cu alloys Microstructure Processing Antibacterial properties
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Diphtheria toxin-derived short peptide enables dual targeted delivery of vorinostat for glioma treatment 认领 引用
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作者 Tianheng Chen Yanyu Zhang +5 位作者 Zhen Fang Anze Liu Yingxin Dong Xiying Wu Feng Yang Huan Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期614-618,共5页
Glioma,a highly aggressive brain tumor with a dismal prognosis,faces significant treatment hurdles due to the blood-brain barrier,which limits the efficient delivery of most medications.Diphtheria toxin receptor(DTR)i... Glioma,a highly aggressive brain tumor with a dismal prognosis,faces significant treatment hurdles due to the blood-brain barrier,which limits the efficient delivery of most medications.Diphtheria toxin receptor(DTR)is a specific receptor expressed both on brain microvascular endothelial cells and glioma,emerging as a potentially valuable target for targeted drug delivery system for glioma treatment.In this work,a short peptide(designated DTX)derived from diphtheria toxin,was rational designed and chemical synthesized based on the binding domain to DTR.The function of DTX as a ligand of DTR and the brain/glioma dual targeting efficacy were evaluated in vitro and in vivo.Furthermore,DTX was conjugated to vorinostat(SAHA)to enable its anti-glioma efficacy.The results demonstrated that DTX-SAHA can effectively cross the blood-brain barrier,exhibiting promising anti-glioma efficacy with good biocompatibility.This research confirmed the potential of DTX as the ligand for DTR-mediated intracranial drug delivery. 展开更多
关键词 Blood-brain barrier Diphtheria toxin receptor Glioma Vorinostat Peptide-drug conjugates
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Construction of Magnetic Microbes for Oriented Self-healing of Mortar Cracks 认领 引用
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作者 FENG Yang ZHU Yakun +5 位作者 AI Fengquan RONG Hui JIN Kan WU Honggang CHEN Xiaoxaio DENG Kun 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第2期463-471,共9页
Sporosarcina pasteurii was employed as the strain,with an in-situ magnetization construction,to obtain magnetic microorganisms and oriented self-healing mortar specimens based on them.The magnetic field was used to ac... Sporosarcina pasteurii was employed as the strain,with an in-situ magnetization construction,to obtain magnetic microorganisms and oriented self-healing mortar specimens based on them.The magnetic field was used to achieve the directional migration of magnetic microorganisms during the oriented selfhealing of mortar cracks,improving the rate of self-healing of cracks.The experimental results demonstrate that the magnetic microorganisms are composed of Fe3O4nanosheets attached to the surface of Sporosarcina pasteurii,whose mineralization products are comprised of vaterite primarily.Compared with the pure microbial group,the magnetic microbial group exhibits a faster repair rate,shortening the repair time required to achieve an area repair efficiency of over 90%from 28 days to 14 days,thereby doubling the repair rate.Meanwhile,the area repair efficiency of the magnetic microbial group at 7,14,and 28 days are increased by 50.3%,11.2%,and 4.6%,respectively,compared to the pure microbial group,which are due to the magnetic microorganisms'superior directional migration and mineralization ability,exceeding that of the ordinary microorganisms. 展开更多
关键词 Sporosarcina pasteurii magnetic microorganisms oriented self-healing mortar self-healing rate directional migration
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Piezoelectric scaffold for tissue engineering:material,structure,fabrication and function 认领 引用
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作者 Jiye Jia Junwei Shen +3 位作者 Feng Yang Jing Zhang Cijun Shuai Pei Feng 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期451-490,共40页
The scaffold for tissue engineering not only requires good biocompatibility,mechanical properties,and appropriate structure,but also should actively participate in biophysical and biochemical processes to accelerate t... The scaffold for tissue engineering not only requires good biocompatibility,mechanical properties,and appropriate structure,but also should actively participate in biophysical and biochemical processes to accelerate tissue repair.A piezoelectric scaffold can generate electrical activity when deformed,which constructs an electrochemical microenvironment for inducing cell signaling pathways and facilitating tissue regeneration,attracting extensive attention in tissue engineering.Herein,piezoelectric materials used in tissue engineering,including piezoelectric ceramics,synthetic piezoelectric polymers,and natural biological piezoelectric materials are systematically summarized,and their advantages and limitations are analyzed.As for the piezoelectric scaffold,the piezoelectric properties mainly stem from the asymmetric crystal structure of materials and the directional arrangement of internal dipoles,which is highly dependent on the fabrication and post-treatment strategies.Therefore,the fabrication techniques of piezoelectric scaffold are detailly introduced,covering both traditional fabrication techniques and additive manufacturing techniques.Besides,rational structural design of the piezoelectric scaffold can alter strain transmission pathways and charge distribution,or add new operational modes to regulate piezoelectric properties.Thereby,the piezoelectric metamaterials,microanostructures,porous structures,heterogeneous structures,and biomimetic structures are comprehensively summarized.Additionally,the functions of piezoelectric scaffold for tissue engineering application in terms of bone regeneration,neural regeneration,antibacterial activity,and intelligent sensing are reviewed.Finally,the challenges and future research directions of the piezoelectric scaffold are discussed. 展开更多
关键词 piezoelectric scaffold fabrication techniques structural design piezoelectric properties tissue engineering
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Electronic structure and superconducting gap of HgBa2Ca2Cu3O8+δrevealed by laserbased angle-resolved photoemission spectroscopy 认领 引用
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作者 Taimin Miao Wenshan Hong +18 位作者 Qinghong Wang Shanshan Zhang Bo Liang Wenpei Zhu Neng Cai Mingkai Xu Shenjin Zhang FengFeng Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Hanqing Mao Zhihai Zhu Xintong Li Guodong Liu Lin Zhao Yuan Li X.J.Zhou 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第2期257-263,共7页
The spatially-resolved laser-based high resolution angle resolved photoemission spectroscopy(ARPES)measurements have been performed on the optimally-doped HgBa2Ca2Cu3O8+δ(Hg1223)superconductor with a T_(c... The spatially-resolved laser-based high resolution angle resolved photoemission spectroscopy(ARPES)measurements have been performed on the optimally-doped HgBa2Ca2Cu3O8+δ(Hg1223)superconductor with a Tc of 133 K.Two distinct regions are identified on the cleaved surface:the single Fermi surface region where only one Fermi surface is observed,and the double Fermi surface region where two Fermi surface sheets are resolved coming from both the inner(IP)and outer(OP)CuO2 planes.The electronic structure and superconducting gap are measured on both of these two regions.In both cases,the observed electronic states are mainly concentrated near the nodal region.The momentum dependence of the superconducting gap deviates from the standard d-wave form.These results indicate that the surface electronic structure of Hg1223 behaves more like that of underdoped cuprates. 展开更多
关键词 cuprate angle resolved photoemission spectroscopy(ARPES)
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Delayed photosynthesis response causes carbon assimilation reduction in soybean under fluctuating light 认领 引用
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作者 Jing Gao Shenglan Li +7 位作者 Yi Lei Qi Wang Zili Ning Zhaohong Lu Xianming Tan Mei Xu Feng Yang Wenyu Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期648-658,共11页
Plants encounter dynamic light environments in natural field conditions,and species differ in their physiological and biochemical mechanisms for acclimating to fluctuating light(FL).The manner in which soybean(Glycine... Plants encounter dynamic light environments in natural field conditions,and species differ in their physiological and biochemical mechanisms for acclimating to fluctuating light(FL).The manner in which soybean(Glycine max(L.) Merr.) coordinates multiple physiological adjustments to FL remains poorly understood.This study assessed the effects of FL on soybean morphology and photosynthetic traits by examining changes in photosynthetic gas exchange parameters and chlorophyll(Chl) a fluorescence under alternating high-and low-light conditions.Results indicated that soybeans exposed to FL exhibited reduced dry matter accumulation,smaller and thinner leaves,and a lower Chl a/Chl b levels-characteristics typically associated with plants grown under continuous low-light.Despite these morphological similarities,their photosynthetic gas exchange rates and photosynthetic capacity were maintained at levels comparable to those under steady high light,unlike plants grown under constant low-light.Thus,acclimation to FL is distinct from adaptation to sustained low-light conditions.Correlation analyses revealed that the decline in carbon assimilation under FL primarily stemmed from two factors:the slow recovery of stomatal conductance upon transition to high light and the delayed relaxation of nonphotochemical quenching when light intensity decreased.Therefore,the reduction in carbon assimilation under FL cannot be attributed to low-light phase adjustments but rather reflects a lag in photosynthetic responsiveness to changing light conditions. 展开更多
关键词 soybean fluctuating light CO2assimilation dynamic photosynthesis photosynthetic limitation stomatal opening non-photochemical quenching
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A Mechanically Robust and Low Heat Build-up Rubber Formed by Isoprene Rubber Assembled with Eucommia Ulmoides Gum via Hydrogen Bonding 认领 引用
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作者 Xin-Yuan Wang Chao-Fan Li +4 位作者 Hai-Lan Kang Dong-Han Li Qing-Hong Fang Long Li Feng Yang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第3期845-856,I0017,共12页
To combine the high elasticity and good mechanical performance of isoprene rubber(IR)with excellent fatigue resistance and low heat build-up of Eucommia ulmoides gum(EUG),the present study employed a chemical method t... To combine the high elasticity and good mechanical performance of isoprene rubber(IR)with excellent fatigue resistance and low heat build-up of Eucommia ulmoides gum(EUG),the present study employed a chemical method to graft 4-amino pyridine(AP)onto epoxidized IR and EUG,thereby creating a chemical assembly rubber of amino-pyridine-grafted epoxidized IR(AP-EIR)and amino pyridine-grafted epoxidized EUG(AP-EEUG)via a dynamic hydrogen bonding network.The presence of hydrogen bonds between AP-EIR and AP-EEUG was confirmed by variable temperature infrared spectroscopy,whereas scanning electron microscopy-energy dispersive spectroscopy revealed a uniform dispersion of zinc oxide and nano-fillers.Hydrogen bonds significantly facilitate strain-induced crystallization between the AP-EIR and AP-EEUG molecules,thereby strengthening their intermolecular interactions.During mechanical deformation,the material primarily dissipates energy through the breaking of hydrogen bonds,which effectively improves the mechanical strength of the material,and the introduction of amino groups in this chemical assembly rubber improves the uniform dispersion of nano-fillers,as well as the interface interaction between rubber and nano-fillers.Consequently,the chemically assembled rubber exhibited superior modulus,tensile strength,and tear strength compared to IR and its physical blend,while also demonstrating reduced heat build-up during dynamic loading. 展开更多
关键词 Isoprene rubber Eucommia ulmoides gum Hydrogen bond Chemically assemble
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Value of inflammatory markers in predicting psychotic complications of postoperative depression after cerebrovascular intervention 认领 引用
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作者 Feng Yang Ru-Juan Zhou +3 位作者 Wu Xu Yan Li Dong-Heng Luan Ming-Yang Xu 《World Journal of Psychiatry》 SCIE 2026年第6期219-228,共10页
BACKGROUND Post-intervention depression with psychotic features represents a severe complication in cerebrovascular intervention that substantially impedes recovery and quality of life.Growing evidence implicates neur... BACKGROUND Post-intervention depression with psychotic features represents a severe complication in cerebrovascular intervention that substantially impedes recovery and quality of life.Growing evidence implicates neuroinflammation as a key pathophysiological mechanism linking procedural stress,ischemia-reperfusion injury,and the development of post-procedural neuropsychiatric sequelae.Identifying reliable biomarkers for early risk stratification is crucial for preemptive management.AIM To investigate the value of human chitinase-3-like protein 1(YKL-40/CHI3L1),high-sensitivity C-reactive protein,and interleukin-6 in predicting psychotic complications of postoperative depression following cerebrovascular intervention.METHODS General patient data from 94 patients who underwent cerebrovascular intervention and serum levels of YKL-40,high-sensitivity C-reactive protein,and interleukin-6 measured preoperatively and on postoperative day 1,days 3,and days 7 were collected and compared between the two groups.Multivariate logistic regression identified independent risk factors for psychotic complications.Receiver operating characteristic curve analysis evaluated the predictive efficacy of each inflammatory marker,and the correlation between inflammatory marker levels and psychiatric assessment scale scores was analyzed.RESULTS Univariate and multivariate logistic regression analyses identified YKL-40 levels on postoperative day 3,National Institute of Health Stroke Scale scores on postoperative day 7,and intraoperative complications as independent risk factors for postoperative depressive disorder with psychotic complications(P<0.05).Receiver operating characteristic curve analysis indicated that the inflammatory markers measured on postoperative day 3 had the highest predictive value.Among them,YKL-40 had the largest area under the curve of 0.892(95%confidence interval:0.821-0.963),with an optimal cut-off value of 156.4 ng/mL,yielding a sensitivity of 85.7%and a specificity of 84.8%.Spearman correlation analysis revealed that YKL-40 levels on postoperative day 3 in the complication group were significantly positively correlated with both Hamilton Depression Rating Scale-17 scores(r=0.612,P<0.001)and Positive and Negative Syndrome Scale positive subscale scores(r=0.584,P<0.001).CONCLUSION YKL-40 demonstrated good predictive efficacy for psychotic complications of depression following cerebrovascular intervention.Dynamic monitoring of YKL-40 can facilitate early identification of high-risk patients and enable timely,effective interventions. 展开更多
关键词 Inflammatory markers Cerebrovascular intervention Postoperative depression Psychotic complications Predictive value
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基于在体单向肠灌流和Caco-2细胞模型的金振口服液肠吸收特性研究 认领 引用
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作者 常榕蓉 尹兴斌 +10 位作者 冯洋 孙宇菲 荆霄鸿 尹东阁 董晓旭 曲昌海 王振中 王团结 雷海民 倪健 肖伟 《中草药》 CAS CSCD 北大核心 2026年第4期1391-1401,共11页
目的 采用大鼠在体单向肠灌流与Caco-2细胞模型系统探究金振口服液中黄芩苷、甘草酸、芦荟大黄素、汉黄芩素、大黄素、大黄酚6种成分的肠吸收特性。方法 体外实验借助Caco-2单层细胞模型,通过表观渗透系数(apparent permeability coeffi... 目的 采用大鼠在体单向肠灌流与Caco-2细胞模型系统探究金振口服液中黄芩苷、甘草酸、芦荟大黄素、汉黄芩素、大黄素、大黄酚6种成分的肠吸收特性。方法 体外实验借助Caco-2单层细胞模型,通过表观渗透系数(apparent permeability coefficient,Papp)初步评价6种成分的吸收能力;体内实验借助大鼠在体肠灌流,通过吸收速率常数(Ka)和有效渗透系数(effective permeability coefficient,Peff)进一步验证6种成分在大鼠肠段(十二指肠、空肠、回肠以及结肠)的吸收情况;对比分析体内外吸收规律并解析金振口服液中6种成分吸收规律。结果 体内外实验结果呈现较好的一致性。在低、中、高3种浓度灌流条件下,6种成分在大鼠的各个肠段均具有可吸收性。其中Peff值在十二指肠、空肠、结肠中均大于1.2×10−3 cm/min,表明6种成分在该3肠段均吸收良好;在回肠段,黄芩苷、甘草酸、汉黄芩素Peff值为1.8×10−4~1.2×10−3 cm/min,表明该3种成分在回肠段吸收情况适中;芦荟大黄素、大黄素、大黄酚Peff值大于1.2×10−3 cm/min,表明该3种成分在回肠肠段吸收良好。另外,该6种成分的吸收机制存在差异,且多数成分存在主动转运、促进扩散等需载体参与的吸收特征(部分呈浓度相关性或饱和性),同时也有成分以被动扩散为主或主动与被动转运共同参与。结论 体内外肠吸收实验揭示了金振口服液中6种主要成分的肠段特异性吸收规律,其整体吸收情况良好,符合口服制剂的要求。 展开更多
关键词 金振口服液 肠吸收特性 在体单向肠灌流 Caco-2细胞模型 黄芩苷 甘草酸 芦荟大黄素 汉黄芩素 大黄素 大黄酚
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支链结构对流延和双向拉伸聚丙烯薄膜介电储能特性的影响 认领 引用
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作者 于是乎 刘培焱 +4 位作者 彭向阳 周彬 李银格 冯阳 李盛涛 《高电压技术》 EI CAS CSCD 北大核心 2026年第6期2545-2553,共9页
聚丙烯(PP)作为薄膜电容器中的核心材料,接枝改性将对其性能产生显著影响。为了研究支链结构对PP结晶和介电储能特性的影响,采用固相接枝法接枝了马来酸酐(MAH)和聚醚酰亚胺(PEI),并基于电容器薄膜生产工艺制备了流延膜和双向拉伸薄膜... 聚丙烯(PP)作为薄膜电容器中的核心材料,接枝改性将对其性能产生显著影响。为了研究支链结构对PP结晶和介电储能特性的影响,采用固相接枝法接枝了马来酸酐(MAH)和聚醚酰亚胺(PEI),并基于电容器薄膜生产工艺制备了流延膜和双向拉伸薄膜。结果表明,极性基团的引入能够充分提高PP的极性,使相对介电常数增加。同时,接枝改性引入的支链结构能够降低流延膜的晶面间距,而接枝PEI后的长支链结构则使PP分子缠结更加紧密,晶面间距保持最小。双向拉伸后,PP分子链将解缠且排布更加有序,引起结晶度的上升,表现为直流击穿场强的增加。在拉伸应力下,接枝PEI后的长支链结构导致PP分子链缠结位点始终存在,引起分子链断裂,排布更加松散,因而晶面间距增大,直流击穿场强提升幅度较小。综合相对介电常数和直流击穿场强的变化情况,接枝MAH的双向拉伸薄膜表现出最优的储能特性,放电能量密度相较于PP提升了29.8%,充放电效率始终保持在90%以上。研究结果为PP接枝改性基团的选择提供了一定的指导。 展开更多
关键词 支链结构 接枝改性 双向拉伸 晶面间距 直流击穿强度 储能特性
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假禾谷镰孢菌生物学特性与亚磷酸钾诱导小麦茎基腐病抗性 认领 引用
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作者 王鹤 张永超 +4 位作者 肖恒博 冯阳 梁鑫艳 熊芹 韩彦卿 《核农学报》 CAS CSCD 北大核心 2026年第8期1653-1662,共10页
茎基腐病(Fusarium crown rot)是严重威胁小麦生产的重要病害之一。为明确山西省小麦茎基腐病的优势致病菌假禾谷镰孢菌(Fusarium pseudograminearum)的生物学特性,并评估亚磷酸钾对其的抑制作用,本研究系统测定了该病原菌在不同培养基... 茎基腐病(Fusarium crown rot)是严重威胁小麦生产的重要病害之一。为明确山西省小麦茎基腐病的优势致病菌假禾谷镰孢菌(Fusarium pseudograminearum)的生物学特性,并评估亚磷酸钾对其的抑制作用,本研究系统测定了该病原菌在不同培养基、光照、温度和pH值条件下的菌落形态及产孢量,分析了亚磷酸钾在室内平板中对菌丝生长和产孢数量的抑制效应,并通过盆栽试验探究其对小麦茎基腐病的防控效果及对植株防御酶活性的影响。结果表明,假禾谷镰孢菌在PSA培养基上产孢量最高,光暗交替(12 h/12 h)条件可促进其产孢,在pH值9的碱性环境下产孢能力最强,最适产孢温度为25℃。室内抑制试验表明,亚磷酸钾可有效抑制菌丝生长,并引起菌丝和孢子形态异常,其中0.02 mol·L-1亚磷酸钾处理抑制效果最佳,且导致孢子数量急剧下降。盆栽试验进一步表明,经亚磷酸钾溶液处理后,小麦植株中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化物酶(POD)的活性较未接菌和接菌处理发病小麦的酶活性均明显升高,并于24 h时达到峰值。同时,该处理有效减轻了茎基腐病的发病程度,表现为病茎长度缩短、病斑颜色变浅。综上,假禾谷镰孢菌的产孢能力受培养基类型、光周期和pH值调控,而亚磷酸钾可通过快速激活小麦防御酶系统增强其抗病性。本研究结果为山西省小麦茎基腐病的绿色防控提供了理论依据和潜在防治策略。 展开更多
关键词 假禾谷镰孢菌 生物学特性 亚磷酸钾 抑制效果 小麦茎基腐病
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基于风险指引的核电厂CLRT周期延长研究 认领 引用
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作者 刘宇 王聪 +4 位作者 喻新利 余蕴 魏玮 封杨 李文静 《核动力工程》 EI CAS CSCD 北大核心 2026年第2期285-291,共7页
核电厂安全壳密封性试验(CLRT)包括整体密封性试验(ILRT)和局部密封性试验(LLRT),频繁的试验会降低核电厂可利用率,尤其是ILRT极大地占用换料大修的关键路径,严重影响核电经济性。目前美国已有多台核电机组基于良好的安全壳性能试验记录... 核电厂安全壳密封性试验(CLRT)包括整体密封性试验(ILRT)和局部密封性试验(LLRT),频繁的试验会降低核电厂可利用率,尤其是ILRT极大地占用换料大修的关键路径,严重影响核电经济性。目前美国已有多台核电机组基于良好的安全壳性能试验记录将ILRT周期延长至15 a,LLRT周期也相应延长,但国内相关周期延长方案尚未实施。本文整合确定论与概率论方法,研究了基于风险指引的核电厂CLRT周期延长方法,识别了重要风险指标、评价了周期延长后的风险影响并探究了风险接受准则。以国内某压水堆核电机组(预应力混凝土安全壳)为例论证了CLRT周期延长的可行性,并建立了概率论评估模型、计算了周期延长后的风险增量。结果表明,CLRT周期延长带来的风险增量可接受。 展开更多
关键词 风险指引 确定论与概率论 安全壳密封性试验(CLRT) 定期试验周期延长
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基于文献计量学的重楼皂苷研究现状及热点分析 认领 引用
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作者 林舒婷 尹东阁 +8 位作者 陈红月 孙宇菲 荆霄鸿 常榕蓉 冯洋 董晓旭 曲昌海 尹兴斌 倪健 《药物评价研究》 CAS 北大核心 2026年第1期286-304,共19页
目的 基于文献计量学总结分析重楼皂苷研究现状及热点,为今后该领域的研究和理论发展提供参考。方法 检索中国学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普生物医学数据库(VIP)和Web of Science核心数据库自建库以来—202... 目的 基于文献计量学总结分析重楼皂苷研究现状及热点,为今后该领域的研究和理论发展提供参考。方法 检索中国学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普生物医学数据库(VIP)和Web of Science核心数据库自建库以来—2024年12月31日发表的重楼皂苷相关文献,应用R语言和CiteSpace软件对整体产出和主题、研究热点分布及趋势,以及英文文献引文情况进行可视化分析。结果 分别纳入1 033和415篇与重楼皂苷相关的中、英文文献,发文量总体呈逐年上升趋势,中国在该研究领域占据核心地位。关于重楼皂苷的国内外研究主要集中在抗肿瘤相关的药理机制、协同给药、逆转耐药,并且靶向抗癌纳米粒成为新兴研究领域。结论 重楼皂苷近年来研究热度不断上升,抗肿瘤是重楼皂苷的主要研究热点,生物工程合成、靶向纳米制剂、毒性研究等可能是重楼皂苷未来新的研究方向。 展开更多
关键词 重楼皂苷 CiteSpace R语言 文献计量学 可视化分析 抗肿瘤
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电缆附件绝缘界面放电故障气体诊断方法 认领 引用
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作者 刘凤莲 薛志航 +3 位作者 张宗喜 苟杨 冯阳 孙韬 《绝缘材料》 CAS 北大核心 2026年第2期77-86,共10页
本文探究了电缆附件交联聚乙烯-硅橡胶绝缘界面在不同放电故障类型下的特征气体生成规律,并以此提出了电缆附件界面放电类型的气体诊断判据。首先搭建电缆附件绝缘界面放电产气实验平台,通过高频电流互感器法区分不同放电故障类型,进一... 本文探究了电缆附件交联聚乙烯-硅橡胶绝缘界面在不同放电故障类型下的特征气体生成规律,并以此提出了电缆附件界面放电类型的气体诊断判据。首先搭建电缆附件绝缘界面放电产气实验平台,通过高频电流互感器法区分不同放电故障类型,进一步通过气相色谱法分析绝缘界面放电故障的逸出气体特性。然后搭建真型电缆附件放电故障产气平台,对界面放电故障下的特征气体生成规律进行实验验证。最后,基于特征气体生成规律提出电缆附件放电故障的诊断判据。结果表明:电缆附件绝缘界面在低能放电(局部放电)下主要生成H2、CO2、CO、CH4和C2H6,在高能放电(电弧放电)下则额外产生C2H4和C2H2。基于此提出了综合性气体诊断判据:当CO和CO2浓度比为0.10~0.69时为低能放电,大于0.70时为高能放电;气体组分中仅含前5种气体对应低能放电,同时检出C2H4和C2H2则对应高能放电。量化指标显示,高能放电中不饱和烃占比为0.07~0.16,不饱和烃与H2的浓度比为0.08~0.30。 展开更多
关键词 电缆附件 绝缘界面 放电故障 气体判据
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长江流域高温事件识别中两类阈值方法对比研究 认领 引用
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作者 胡一阳 秦鹏程 +3 位作者 夏智宏 冯扬 牛自耕 方思达 《人民长江》 北大核心 2026年第5期28-36,47,共9页
全球气候变化背景下,极端高温事件频发加剧了长江流域水资源供需矛盾。为客观揭示长江流域高温事件时空分布特征及其演变趋势,利用流域735个国家气象观测站1961~2022年逐日最高气温资料,分别采用绝对阈值法和相对阈值法识别长江上游、... 全球气候变化背景下,极端高温事件频发加剧了长江流域水资源供需矛盾。为客观揭示长江流域高温事件时空分布特征及其演变趋势,利用流域735个国家气象观测站1961~2022年逐日最高气温资料,分别采用绝对阈值法和相对阈值法识别长江上游、中下游暖季区域性高温事件,并从发生频次、时空分布、综合强度等多个维度对比分析两类阈值方法的适用性与敏感性。结果表明:(1)绝对阈值法在长江上游和中下游分别识别出299次和383次高温事件,相对阈值法在长江上游和中下游分别识别出423次和410次高温事件,相对阈值法对长江上游高温事件更敏感。(2)绝对阈值法识别出的高温事件集中于7~8月,相对阈值法识别出的高温事件在5~9月分布较均匀,绝对阈值法对极端高温时段响应更灵敏。(3)绝对阈值法识别的高温事件持续时间在7.1~8.7 d之间,相对阈值法识别的高温事件平均持续时间仅5.4 d,绝对阈值法对高温过程持续时间识别更稳定。(4)两种方法识别出的典型高温年一致率为60%,均揭示出近60年来区域性高温事件频次和强度呈显著上升趋势,21世纪以来高温事件极端性显著增强。相对阈值法对气候变化响应更敏感,而绝对阈值法对高强度极端高温事件刻画更突出。研究成果可为长江流域高温事件研究和应对提供参考。 展开更多
关键词 区域性高温事件 相对阈值法 绝对阈值法 长江流域
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基于网络药理学与实验验证探讨参叶消癥颗粒改善慢性萎缩性胃炎的作用机制 认领 引用
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作者 孙宇菲 尹东阁 +9 位作者 常榕蓉 荆霄鸿 林舒婷 陈红月 冯洋 邓兮玺 杨洋 倪健 魏玮 尹兴斌 《中南药学》 CAS 2026年第5期119-125,共7页
目的探讨参叶消癥颗粒对于慢性萎缩性胃炎(CAG)的治疗作用及其可能的作用机制。方法通过网络药理学方法,包括建立蛋白-蛋白相互作用网络、GO/KEGG富集分析以及分子对接等方法,预测参叶消癥颗粒在CAG治疗过程中的潜在靶点和机制。随后采... 目的探讨参叶消癥颗粒对于慢性萎缩性胃炎(CAG)的治疗作用及其可能的作用机制。方法通过网络药理学方法,包括建立蛋白-蛋白相互作用网络、GO/KEGG富集分析以及分子对接等方法,预测参叶消癥颗粒在CAG治疗过程中的潜在靶点和机制。随后采用N-甲基-N'-硝基-N-亚硝基胍(MNNG)诱导建立人胃黏膜上皮细胞(GES-1)细胞模型。利用CCK8法及TUNEL染色法分析细胞凋亡情况,利用酶联免疫吸附测定法(ELISA)、逆转录实时荧光定量聚合酶链式反应法(RT-qPCR)、蛋白质印迹法(Western blot)等分析细胞中炎症因子以及靶点蛋白等相关指标,进一步验证网络药理学结果。结果网络药理学结果显示,参叶消癥颗粒与CAG之间有106个重叠靶点,与细胞凋亡、炎症和PI3K/AKT通路相关。分子对接结果显示核心靶点AKT1、TNF、CASP3、Bcl2、HIF1A与参叶消癥颗粒活性成分之间具有很强的亲和力。体外细胞实验结果显示,参叶消癥颗粒在700μg/mL时对GES-1细胞无毒性,并且选择40μmol/L作为MNNG诱导GES-1细胞模拟CAG的造模浓度。参叶消癥颗粒在100μg/mL以上时能够抑制MNNG诱导的细胞凋亡,在300μg/mL及以上时能够显著抑制PI3K/AKT磷酸化,抑制PI3K、AKT、BAX和Caspase-3的表达,同时促进Bcl-2的表达。结论参叶消癥颗粒能够抑制MNNG诱导的GES-1细胞炎症和凋亡,可能是通过调节PI3K/AKT通路和凋亡相关蛋白发挥作用。 展开更多
关键词 慢性萎缩性胃炎 参叶消癥颗粒 网络药理学 分子对接 PI3K/AKT通路
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反浮选磷尾矿基地聚物的制备及其水化机制研究 认领 引用
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作者 张远永 张随雨 +2 位作者 刘远 冯洋 杨林 《无机盐工业》 CAS CSCD 北大核心 2026年第4期114-120,共7页
为扩展磷尾矿资源化利用途径,以反浮选磷尾矿、粉煤灰、赤泥、水玻璃为原料制备地聚物,测试磷尾矿掺量对地聚物流动度及抗压强度的影响,采用XRD、FT-IR、TG-DTG、SEM-EDS等分析地聚物水化产物的物相组成,官能团及微观形貌,并对磷尾矿基... 为扩展磷尾矿资源化利用途径,以反浮选磷尾矿、粉煤灰、赤泥、水玻璃为原料制备地聚物,测试磷尾矿掺量对地聚物流动度及抗压强度的影响,采用XRD、FT-IR、TG-DTG、SEM-EDS等分析地聚物水化产物的物相组成,官能团及微观形貌,并对磷尾矿基地聚物的水化硬化机制进行分析。结果表明,随着磷尾矿掺量增大,地聚物流动度增大,抗压强度先增大后减小。当采用60%(质量分数,下同)磷尾矿、20%赤泥、20%粉煤灰,以及外掺20%水玻璃与3%氢氧化钠时,磷尾矿基地聚物具有良好的性能,流动度为185 mm,28 d抗压强度为30.6 MPa。磷尾矿与碱发生去白云石化反应生成氢氧化钙,并释放出少量的Ca2+。氢氧化钠及水玻璃与粉煤灰、赤泥反应生成水化铝硅酸钙和水化铝硅酸钠凝胶,凝胶产物黏结磷尾矿颗粒形成硬化块体,使磷尾矿基地聚物具有高的力学强度。 展开更多
关键词 反浮选磷尾矿 地聚物 水化铝硅酸钙 水化机制
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红光治疗设备校准方法探讨 认领 引用
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作者 莫海燕 赵紫艳 +3 位作者 刘洋 张方申 酆扬 于海容 《中国标准化》 2026年第12期247-251,共5页
红光治疗设备作为新型光疗设备,通过获取600~760 nm的红色可见光,利用该波段对人体深层组织穿透力强,能产生高效率的光化学生物效应等特点,在医学各领域得到有效而广泛的应用。因此,为保障临床治疗效果、降低设备使用风险,加强红光治疗... 红光治疗设备作为新型光疗设备,通过获取600~760 nm的红色可见光,利用该波段对人体深层组织穿透力强,能产生高效率的光化学生物效应等特点,在医学各领域得到有效而广泛的应用。因此,为保障临床治疗效果、降低设备使用风险,加强红光治疗设备的质量管理显得尤为重要。本文提出了红光治疗设备的校准方法,将有效红光辐照度、温度监测、辐照时间和噪声作为计量参数,给出了计量特性和测量标准等技术要求,并进行临床试验验证,为红光治疗设备的质量控制提供了技术支撑。 展开更多
关键词 红光治疗设备 质量控制 校准方法
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