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Enhancing tumor-associated carbohydrate antigen vaccine efficacy through synergistic antibody recruitment:A combined strategy targeting TACA heterogeneity 认领 引用
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作者 Dan Li Haofei Hong +3 位作者 Han Lin Teng Xu Zhifang Zhou Zhimeng Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期416-420,共5页
Tumor-associated carbohydrate antigen(TACA)-based cancer vaccines face clinical challenges due to heterogeneous TACA expression,which compromises antibody-mediated tumor recognition and leads to suboptimal therapeutic... Tumor-associated carbohydrate antigen(TACA)-based cancer vaccines face clinical challenges due to heterogeneous TACA expression,which compromises antibody-mediated tumor recognition and leads to suboptimal therapeutic outcomes.To address this limitation,we report a combined strategy that integrates vaccination with TACA-based antibody-recruiting molecules.This approach simultaneously redirects antiTACA antibodies to tumor cells expressing a secondary target,thereby enhancing the efficacy of TACA-based vaccines.Using sialyl-Tn(sTn)as a model TACA and epidermal growth factor receptor(EGFR)and human epidermal growth factor receptor 2(HER2)as model protein targets,we designed two nanobody(Nb)-sTn conjugates as TACA-based antibody-recruiting molecules:EGFR-targeting 7D12-sTn and HER2-targeting C7b-s Tn.These conjugates were synthesized via sortase A-mediated ligation and demonstrated strong binding profiles.Importantly,they effectively redirected anti-s Tn antibodies,generated by the Theratope vaccine,to target cells in situ,significantly improving the recognition of tumor cells by antis Tn antibodies.The synergistic potential of these conjugates in amplifying the therapeutic effect of the s Tn-KLH vaccine was further validated through complement-dependent cytotoxicity assays.This innovative strategy represents a highly promising approach to overcome the clinical challenges posed by TACA heterogeneity in cancer vaccine development. 展开更多
关键词 Cancer vaccine Carbohydrates Immunotherapies Nanobody Sialyl-Tn
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A High-Power,Flexible,and Magnetically Attachable Radiative Cooling Film 认领 引用 被引量：1
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作者 Xianbo Nian Keng-Te Lin +7 位作者 Ke Li Jifang Hei Jihong Han Yun Li Chunsheng Guo Han Lin Jinchuan Zheng Baohua Jia 《Engineering》 SCIE EI CSCD 2025年第6期122-133,共12页
Radiative cooling is an environmentally friendly,passive cooling technology that operates without energy consumption.Current research primarily focuses on optimizing the optical properties of radiative cooling films t... Radiative cooling is an environmentally friendly,passive cooling technology that operates without energy consumption.Current research primarily focuses on optimizing the optical properties of radiative cooling films to enhance their cooling performance.In practical applications,thermal contact between the radiative cooling film and the object significantly influences the ultimate cooling performance.However,achieving optimal thermal contact has received limited attention.In this study,we propose and experimentally demonstrate a high-power,flexible,and magnetically attachable and detachable radiative cooling film.This film consists of polymer metasurface structures on a flexible magnetic layer.The monolithic design allows for convenient attachment to and detachment from steel or iron surfaces,ensuring optimal thermal contact with minimal thermal resistance and uniform temperature distribution.Our magnetic radiative cooling film exhibits superior cooling performance compared to non-magnetic alternatives.It can reduce the temperature of stainless-steel plates under sunlight by 15.2℃,which is 3.6℃ more than that achieved by non-magnetic radiative cooling films.The radiative cooling power can reach 259W·m-2 at a working temperature of 70℃.Unlike other commonly used attachment methods,such as thermal grease or one-off tape,our approach allows for detachment and reusability of the cooling film according to practical needs.This method offers great simplicity,flexibility,and cost-effectiveness,making it promising for broad applications,particularly on non-horizontal irregular surfaces previously considered challenging. 展开更多
关键词 Radiative cooling Thermal management Magnetic Flexible Cooling power
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Flow diagnosis of compressible vortex structures on a 65°delta-wing 认领 引用
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作者 Fanrong XUE Han LIN +3 位作者 Shengye WANG Chuanzhen LIU Shufan ZOU Wei LIU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第3期47-63,共17页
With advancements in computational fluid dynamics,high-fidelity simulations enable flow diagnostics of complex flows to identify critical local structures affecting aerodynamic performance.Based on compressible vortex... With advancements in computational fluid dynamics,high-fidelity simulations enable flow diagnostics of complex flows to identify critical local structures affecting aerodynamic performance.Based on compressible vortex-force theory,the generalized Lamb vector's spatial distribution elucidates force generation mechanisms.This study employs the shear stress transport k-ωturbulence model within the Reynolds-averaged Navier-Stokes equations to accurately capture viscous-dominated boundary layers and shock-induced separation phenomena.Additionally,an aerodynamic computed topography is also utilized to quantify lift contrasting subsonic(Ma∞=0.4)and supersonic(Ma∞=2.0)flows:incompressible Lamb vector contributions dominate subsonic regimes,while compressibility effects characterized by the compressibility term,k∇ρ,prevail in supersonic regimes.The spanwise and freestream-direction components of the Lamb vector and compressibility term are quantitatively evaluated for lift.For delta wings at high angles of attack,zonal scanning decouples vortex-force contributions from separated flow regions,revealing key flow structures governing lift.The vortex-force diagnosis sheds new light on the flow control and configuration optimization. 展开更多
关键词 Aerodynamic computed topography Compressible flow Delta wing aircraft Vortex force
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Advances in metal-hybridized nanoenzymes for catalytic cancer diagnosis and therapy 认领 引用
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作者 Yongfeng Su Fei Yang +3 位作者 Han Lin Jian Han Junda Lu Jianwen Cheng 《Metals Advances》 SCIE EI CAS CSCD 2026年第3期1-15,共15页
As a class of artificial enzyme mimics,nanozymes combine the unique properties of nanomaterials with the catalytic functions of natural enzymes.In recent years,with the rapid development of nanomedicine and nanocataly... As a class of artificial enzyme mimics,nanozymes combine the unique properties of nanomaterials with the catalytic functions of natural enzymes.In recent years,with the rapid development of nanomedicine and nanocatalytic technology,metal-hybridized nanoenzymes(MHNs)have shown great potential with excellent catalytic properties and good biocompatibility,providing new ideas and reference solutions for cancer diagnosis and treatment.This review introduces the latest progress of MHNs,focuses on their specific applications in cancer diagnosis and treatment,explores their potential in cancer marker detection,bioimaging,tumor microenvironment(TME)response,cellular level detection,and provides an in-depth analysis of how MHNs can regulate the TME with their catalytic activity and synergistically enhance the anticancer effect in combination with various means,such as immunotherapy and photothermal therapy(PTT).In addition,we will discuss the key issues and future development directions of current research and breakthroughs in the clinical translation of key bottlenecks,in order to lay the foundation for the promotion of the practical application of MHNs in cancer therapy. 展开更多
关键词 Cancer Metal-hybridized nanoenzymes Diagnosis Therapy
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Giant and light modifiable third-order optical nonlinearity in a free-standing h-BN film 认领 引用 被引量：6
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作者 Jun Ren Han Lin +5 位作者 Xiaorui Zheng Weiwei Lei Dan Liu Tianling Ren Pu Wang Baohua Jia 《Opto-Electronic Science》 2022年第6期1-10,共10页
Recently,hexagonal boron nitride(h-BN)has become a promising nanophotonic platform for on-chip information devices due to the practicability in generating optically stable,ultra-bright quantum emitters.For an integrat... Recently,hexagonal boron nitride(h-BN)has become a promising nanophotonic platform for on-chip information devices due to the practicability in generating optically stable,ultra-bright quantum emitters.For an integrated information-processing chip,high optical nonlinearity is indispensable for various fundamental functionalities,such as all-optical modulation,high order harmonic generation,optical switching and so on.Here we study the third-order optical nonlinearity of free-standing h-BN thin films,which is an ideal platform for on-chip integration and device formation without the need of transfer.The films were synthesized by a solution-based method with abundant functional groups enabling high third-order optical nonlinearity.Unlike the highly inert pristine h-BN films synthesized by conventional methods,the free-standing h-BN films could be locally oxidized upon tailored femtosecond laser irradiation,which further enhances the third-order nonlinearity,especially the nonlinear refraction index,by more than 20 times.The combination of the free-standing h-BN films with laser activation and patterning capability establishes a new promising platform for high performance on-chip photonic devices with modifiable optical performance. 展开更多
关键词 hexagonal boron nitride third-order nonlinearity laser oxidation optoelectronic device
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Real-Time Machine Learning-Based Position Recognition in Laser Nanofabrication with Sub-Half-Wavelength Precision 认领 引用
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作者 Hao Zhang Jinchuan Zheng +2 位作者 Guiyuan Cao Han Lin Baohua Jia 《Engineering》 SCIE EI CSCD 2026年第2期200-209,共10页
Laser nanofabrication with tightly focused ultrafast laser pulses enable versatile fabrication of arbitrary two-dimensional(2D)hree-dimensional(3D)microanostructures.Accurate positioning of the laser focal spot is cru... Laser nanofabrication with tightly focused ultrafast laser pulses enable versatile fabrication of arbitrary two-dimensional(2D)hree-dimensional(3D)microanostructures.Accurate positioning of the laser focal spot is crucial,especially for high-resolution integrated devices in 2D materials,requiring precise placement on atomically thin surfaces.However,uneven surfaces and surface tilt poses significant challenges.Existing methods to detect focal positions often involve complex setups with additional optical components or sensors,achieving limited accuracy.This study introduces a machine learning-based method to accurately detect the focal position during laser nanofabrication by analyzing the shape and intensity of the laser focal spot.We compare four machine learning methods:rational quadratic Gaussian process regression,kernel approximation least square,quadratic support vector machine,and trilayered neural network.Our experiments show that trilayered neural network(TNN)method achieves a detection accuracy of 257 nm(half the fabrication laser wavelength),surpassing the required accuracy for tightly focused laser beam(typically larger than one wavelength).This method can map focal positions along the fabrication trajectory to compensate for surface roughness or tilt.Moreover,it can be directly implemented in any laser nanofabrication system with a camera for in situ monitoring,without requiring additional optical components,indicating broad applicability. 展开更多
关键词 Laser nanofabrication Machine learning Image-based position recognition Neural network Image processing
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Cost-effectiveness of sponge cytology test vs endoscopy for esophageal squamous cell carcinoma screening in high-risk areas 认领 引用
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作者 Yu-Si Xu Ye Gao +8 位作者 Yun-Fei Jiao Chu-Ting Yu Wei Wang Ting-Lu Wang Chu Chu Han Lin Jin-Fang Xu Lei Xin Luo-Wei Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第3期224-237,共14页
BACKGROUND Recent advances in esophageal sponge cytology tests highlight their potential in esophageal squamous cell carcinoma(ESCC)screening,but their cost-effectiveness remains unclear.AIM To investigate the cost-ef... BACKGROUND Recent advances in esophageal sponge cytology tests highlight their potential in esophageal squamous cell carcinoma(ESCC)screening,but their cost-effectiveness remains unclear.AIM To investigate the cost-effectiveness of the sponge cytology test for ESCC screening in high-risk areas.METHODS We built a Markov model simulating 100000 participants aged 45 years in ESCC high-risk areas to project the cost-effectiveness of several screening strategies:No screening,endoscopic screening,and sponge cytology screening(with subsequent endoscopy for positive results)with different intervals.Outcomes included ESCC cases and deaths,cost,quality-adjusted life year(QALY),and incremental costeffective ratio(ICER).RESULTS All screening strategies reduced ESCC cases and prevented deaths compared with no screening(373-2962 vs 3134 and 257-2305 vs 2409 per 100000 participants,respectively).Shorter screening intervals were associated with higher QALYs gained per person(one-time to per year:532-5972 for endoscopy and 747-7162 for sponge cytology test).An annual sponge cytology test strategy was considered the most cost-effective with the greatest QALYs gained and an ICER of 6630 USD per QALY among all strategies.Endoscopy screening strategies were dominated by the annual sponge cytology strategy.CONCLUSION Our findings suggest that the sponge cytology screening strategy is cost-effective in ESCC high-risk areas and may inform policy decision-making. 展开更多
关键词 Cost-effectiveness Early detection of cancer Diagnostic test Esophageal squamous cell carcinoma Markov model Sponge cytology test Endoscopic screening
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High-power radiatively cooled thermoelectric generator for diurnal waste heat harvesting 认领 引用
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作者 Jifang Hei Han Lin +7 位作者 Xianbo Nian Ke Li Wenhan Li Jun Ma Zheng Li Chunsheng Guo Keng-Te Lin Baohua Jia 《Materials Reports(Energy)》 EI 2026年第1期74-83,共10页
Governed by the second law of thermodynamics,waste heat generation is inevitable and has been a major source of energy loss and environmental concern in human society.Harvesting waste heat into useful energy has thus ... Governed by the second law of thermodynamics,waste heat generation is inevitable and has been a major source of energy loss and environmental concern in human society.Harvesting waste heat into useful energy has thus become a paramount priority,but has remained challenging with efficiency and cost constraints.Thermoelectric generators(TEGs),which convert heat into electricity whenever there is a temperature difference,play a crucial role in waste heat harvesting.However,sustaining the temperature difference for uninterrupted and high-power density electricity generation is a major challenge in TEGs to achieve practical applications due to the thermal equilibrium.Here,we demonstrate a diurnal waste heat harvester by integrating a high-power radiative cooling film as the cool end of TEGs to enable a large and continuous temperature difference.Significant voltage increase from 30.0 mV to 65.7 mV was achieved,leading to a dramatic power density enhancement of 4.8 times from 35.2 mW m-2to 168.6 mW m-2.In an open zone,an ultra-high power density of 2.76 W m-2was achieved at a heat source temperature of 80°C,exceeding the performance of state-of-the-art radiatively cooled TEGs.More importantly,a portable and foldable thermal energy harvesting prototype composed of 24 TEGs arranged in an array has been constructed.When attached to a hot object(e.g.a car engine hood),it can output 5 V to charge personal electronics(e.g.a cellphone),making it a promising practical device for harvesting waste heat in a wide range of outdoor applications. 展开更多
关键词 Radiative cooling Thermoelectric generator Waste heat harvesting Power density Diurnal energy harvesting
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Single-pulse lithography of amorphous photonic architectures inside all-inorganic dielectric crystals 认领 引用
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作者 Zhuo Wang Rongze Ma +6 位作者 Han Lin Pengfei Zhang Yu Lu Feng Chen Baohua Jia Bo Zhang Jianrong Qiu 《Light: Science & Applications》 SCIE EI CAS CSCD 2026年第6期1985-1995,共11页
High-efficiency light modulation within transparent substrates is critically important for advancing in-chip integrated optical technologies.However,current microanophotonic platforms primarily rely on 2D surface conf... High-efficiency light modulation within transparent substrates is critically important for advancing in-chip integrated optical technologies.However,current microanophotonic platforms primarily rely on 2D surface configurations,rendering them inadequate for 3D optical design in dielectric environments.Here,we introduce a precise phase-transition technique that enables the direct lithography of highly regular amorphous units in multiple transparent dielectric crystals(lithium niobates,quartz,yttrium vanadate,etc.).This unit can be rapidly written with a single ultrafast laser pulse,exhibiting a high-purity amorphization phase transition interior structure and a regular sheet-like anisotropic spatial morphology(aspect ratio reaching 190:1).We reveal that this amorphization stems from ultrafast laser-driven anisotropic thermal deposition,achieved through the synergy of the light-induced high-density free electrons and thermal effects.Such embedded units achieve more than an order of magnitude improvement in the efficiency of nonlinear beam shaping(~3% second harmonic and~0.1%third harmonic)and offer multiple degrees of freedom for device design.This study establishes a versatile platform for on-demand production of all-dielectric microanophotonic architectures in the free space of transparent dielectrics,unlocking new avenues for 3D integrated photonics. 展开更多
关键词 Amorphous Photonic Architectures High Efficiency Light Modulation Single pulse Lithography d surface configurationsrendering d optical design All inorganic Dielectric Crystals direct lithography transparent substrates
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PROJECTION BASED STATISTICAL FEATURE EXTRACTION WITH MULTISPECTRAL IMAGES AND ITS APPLICATIONS ON THE YELLOW RIVER MAINSTREAM LINE DETECTION 认领 引用 被引量：1
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作者 Zhang Yanning Zhang Haichao +2 位作者 Duan Feng Liu Xuegong Han Lin 《Journal of Electronics(China)》 2009年第3期359-365,共7页
Mainstream line is significant for the Yellow River situation forecasting and flood control.An effective statistical feature extraction method is proposed in this paper.In this method, a between-class scattering matri... Mainstream line is significant for the Yellow River situation forecasting and flood control.An effective statistical feature extraction method is proposed in this paper.In this method, a between-class scattering matrix based projection algorithm is performed to maximize between-class differences, obtaining effective component for classification;then high-order statistics are utilized as the features to describe the mainstream line in the principal component obtained.Experiments are performed to verify the applicability of the algorithm.The results both on synthesized and real scenes indicate that this approach could extract the mainstream line of the Yellow River automatically, and has a high precision in mainstream line detection. 展开更多
关键词 Mainstream line Projection Between-class scatter matrix High-order statistics Skewness
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无机纳米阻燃剂改性聚乳酸研究进展 认领 引用 被引量：1
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作者 陈荣源 张刘博 +5 位作者 师金磊 石彤 韩琳 刘欣 张忠厚 张晓静 《工程塑料应用》 EI CAS CSCD 北大核心 2026年第1期200-206,共7页
聚乳酸(PLA)来源广泛、价格低廉,同时具有良好的力学性能和生物可降解性,在汽车、电子信息等领域拥有巨大的应用前景。然而,PLA的高可燃性且在燃烧过程中易产生熔滴,容易引发二次火灾,导致其在对阻燃性能要求较高的领域应用受限。传统... 聚乳酸(PLA)来源广泛、价格低廉,同时具有良好的力学性能和生物可降解性,在汽车、电子信息等领域拥有巨大的应用前景。然而,PLA的高可燃性且在燃烧过程中易产生熔滴,容易引发二次火灾,导致其在对阻燃性能要求较高的领域应用受限。传统卤素阻燃剂存在燃烧时发烟严重,产生的气体具有腐蚀性和生理毒性等问题。因此,开发新型高效、环境友好的阻燃剂已成为当前研究的紧迫任务。近年来,无机纳米阻燃剂因其高比表面积、独特的纳米效应及良好的热稳定性成为研究热点。首先介绍了聚合物燃烧过程与阻燃机理,然后按照维度分类,系统综述了零维(如金属氢氧化物、金属氧化物、纳米二氧化硅和功能化炭黑)、一维(如碳纳米管、埃洛石纳米管和海泡石纳米管)及二维[如石墨烯衍生物、二维过渡金属碳(氮)化物MXene、金属有机框架和层状双氢氧化物]无机纳米阻燃剂在PLA阻燃改性中的研究进展。这些阻燃剂通过不同的改性方法和协同效应,显著提升了PLA的阻燃性能。最后,对现有研究的成果进行总结与分析,并对未来发展方向进行了展望。 展开更多
关键词 聚乳酸 无机纳米阻燃剂 阻燃性能 复合材料 研究进展
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Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery 认领 引用 被引量：3
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作者 Han Lin Yanchun Li +6 位作者 Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第2期317-322,共6页
Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of TACA.However,an essential requiremen... Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of TACA.However,an essential requirement of this approach is to generate high titers of endogenous antibodies in vivo through pre-immunization,which complicates the immunization procedure and may cause side effects.Herein,we report a new generation of APC-targeting TACA-based supramolecular complex vaccine,assembled by sialyl Thomsen-nouveau-bovine serum albumin-adamantine(sTn-BSA-Ada)and heptavalent rhamnose(Rha)-modifiedβ-cyclodextrin(β-CD)via host-guest interaction.The complex vaccine retained anti-Rha antibodies recruiting capability and facilitated the APCs uptake of the vaccine via the interaction of the Fc-domain with the Fc receptors on APCs.We demonstrate that direct immunization of complex vaccine elicited anti-Rha and anti-sTn specific immune response synchronously,generating a novel self-enhancement effect that can improve the antigen delivery to APCs in high efficacy.The structure-activity relationship(SAR)study proved that complex vaccine 4 with polyethylene glycol 6(PEG 6)linker in host molecule provoked a robust and specific sTn immune response comparable to the pre-immunization approach.The antisera induced by complex vaccine,either through direct immunization or pre-immunization,exhibited equal potency of cytotoxicity against the sTn expression cancer cells.This study provides a general platform for TACA-based vaccines with self-enhancement effects without the need for pre-immunization. 展开更多
关键词 Glycoconjugate vaccine Endogenous antibody APC-targeting Supramolecular complex sTn antigen
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术前MELD-albumin评分在心脏移植患者预后中的应用价值 认领 引用
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作者 周炜 刘晓彬 +2 位作者 徐志云 韩林 李白翎 《海军军医大学学报》 CAS CSCD 北大核心 2026年第7期879-885,共7页
目的探讨术前终末期肝病模型(MELD)及其衍生评分系统(MELD-XI、MELD-albumin)对心脏移植患者预后评估的价值。方法回顾性分析2018年1月至2024年1月在海军军医大学第一附属医院接受心脏移植手术患者的资料。对所有纳入患者进行MELD、MELD... 目的探讨术前终末期肝病模型(MELD)及其衍生评分系统(MELD-XI、MELD-albumin)对心脏移植患者预后评估的价值。方法回顾性分析2018年1月至2024年1月在海军军医大学第一附属医院接受心脏移植手术患者的资料。对所有纳入患者进行MELD、MELD-XI、MELD-albumin评分,并依据围手术期预后(术后28 d死亡与否)分为存活组和死亡组,对比两组患者术前和术中资料。通过ROC曲线分析各MELD评分与患者预后的关联,然后根据较高的AUC选择MELD-albumin作为研究指标,按照MELD-albumin的最佳截断值将患者分为高分组和低分组,比较两组患者围手术期资料。结果共纳入170例患者,其中存活组159例(93.5%)、死亡组11例(6.5%)。死亡组术前血小板计数、左心室射血分数低于存活组,术前脑钠肽、血肌酐水平及MELD、MELD-XI、MELDalbumin评分均高于存活组(均P8.4,42例),高分组患者术后28 d死亡率和术后接受连续性肾脏替代治疗的比例均更高[19.0%(8/42)vs 2.3%(3/128),P<0.001;14.3%(6/42)vs 4.7%(6/128),P=0.039]。结论术前MELD-albumin评分是心脏移植患者术后28 d死亡的独立预测因子,其最佳截断值为8.4分,可有效区分高危与低危人群。 展开更多
关键词 终末期肝病模型 白蛋白 心脏移植 预后 院内死亡
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基于条件语句半不变性分析的循环分裂优化 认领 引用
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作者 韩林 邵晶晶 +3 位作者 聂凯 李浩然 刘浩浩 陈梦尧 《计算机科学》 CSCD 北大核心 2026年第2期117-123,共7页
循环分裂是一种重要的编译优化技术,可有效减少循环控制开销、提升指令流水线效率,并为后续优化创造机会。针对GCC编译器现有循环分裂策略适用范围受限的问题,提出了一种改进的循环分裂优化算法,该算法基于静态单赋值形式,根据循环内条... 循环分裂是一种重要的编译优化技术,可有效减少循环控制开销、提升指令流水线效率,并为后续优化创造机会。针对GCC编译器现有循环分裂策略适用范围受限的问题,提出了一种改进的循环分裂优化算法,该算法基于静态单赋值形式,根据循环内条件变量所在PHI节点的位置,将其区分为循环头PHI节点条件变量和合并PHI节点条件变量,针对这两种条件变量,算法分别进行半不变性分析,并以此选择分裂点,从而实现更通用的循环分裂优化。在申威GCC编译器中实现了该算法。在申威新一代处理器平台上的实验结果显示,相比原有的循环分裂算法,该算法使SPEC CPU 2006测试集中的470.lbm测试程序性能提升8.8%,SPEC CPU 2017测试集中的620.omnetpp_s测试程序性能提升4.3%。所提方法扩展了可优化循环结构的范围,提升了申威GCC编译器的优化效率,可助力国产申威平台的基础软件生态建设。 展开更多
关键词 GCC编译器 循环优化 循环分裂 静态单赋值 控制依赖
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顶板砂岩裂纹扩展规律及断裂行为的加载速率效应 认领 引用
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作者 赵振华 孙虹洁 +3 位作者 韩琳 罗振江 赵振龙 王海龙 《矿业研究与开发》 CAS 北大核心 2026年第4期138-148,共11页
为揭示顶板断裂行为的加载速率效应,以典型矿井顶板砂岩为研究对象,在0.001~10kN/s的加戴速率范围内开展了5个加载速率等级的巴西劈裂试验,分析了抗拉强度、破碎特征、起裂应力、声发射特性、断口微观形貌等力学行为,并基于声发射震源分... 为揭示顶板断裂行为的加载速率效应,以典型矿井顶板砂岩为研究对象,在0.001~10kN/s的加戴速率范围内开展了5个加载速率等级的巴西劈裂试验,分析了抗拉强度、破碎特征、起裂应力、声发射特性、断口微观形貌等力学行为,并基于声发射震源分布,探讨了不同加载速率下试样内部损伤裂纹的演化规律。结果表明,加载速率每增大10倍,抗拉强度增加0.64 MPa,但起裂应力与抗拉强度的比值减小,随加载速率增大,该比值依次为40.13%、36.59%、32.53%、26.17%、15.81%;加载速率每增大10倍,碎块平均尺寸减小0.229mm,破碎程度增大,碎块尺寸分布向均匀化发展;低加载速率下的声发射震源主要沿宏观断裂面出现,而高加载速率下由于裂纹从多个分散的应力集中区萌生和扩展,声发射震源的分布较分散;随加载速率的增大,断口处的穿晶现象越来越显著,从低加载速率下的单裂隙、平直形式,向高加载速率下的多裂隙、复杂形式转变。 展开更多
关键词 抗拉强度 加载速率 声发射 起裂应力 断口形貌
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中国空间站高温材料科学研究进展 认领 引用
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作者 罗兴宏 刘学超 +18 位作者 潘秀红 杨晓光 曹崇德 张兴旺 尹志岗 吴金良 汤明辉 董持衡 王栋樑 张现平 马衍伟 金敏 韩琳 越方禹 张桂圆 李洋 杨健 张佼 孙宝德 《科技导报》 CAS CSCD 北大核心 2026年第10期91-99,共9页
空间微重力环境能够消除因重力所引发的浮力对流、器壁效应等干扰因素,为材料科学研究提供了独特的实验条件。为探究空间环境下材料制备的新规律,研发在地面难以获取的高性能新材料,回顾了自2022年中国空间站梦天实验舱高温材料科学实... 空间微重力环境能够消除因重力所引发的浮力对流、器壁效应等干扰因素,为材料科学研究提供了独特的实验条件。为探究空间环境下材料制备的新规律,研发在地面难以获取的高性能新材料,回顾了自2022年中国空间站梦天实验舱高温材料科学实验柜入轨以来,利用该实验柜开展的19项空间材料科学实验的整体进展情况。同时,着重介绍了拓扑超导单晶制备、多元半导体合金生长、柔性半导体晶体制备、铁基超导材料制造、铝硅合金凝固、杂质偏析机理研究6项代表性项目的研究成果。研究显示,微重力环境能够有效促进材料组分均匀性、晶体完整性、结晶质量以及掺杂浓度等方面的提升,进而改善材料性能,相关成果为空间材料科学研究及未来的空间原位制造提供了重要的实验依据和理论支撑。 展开更多
关键词 中国空间站 微重力 高温材料科学实验柜 空间材料科学
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电-微生物协同系统用于CO2高值转化的研究进展 认领 引用
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作者 韩林 郭禹曼 +6 位作者 李燕 曹珩珩 李嘉婧 杨明浩 汪萌萌 李晋萍 吕永琴 《合成生物学》 CAS CSCD 北大核心 2026年第3期535-566,共32页
随着全球气候变化问题的日益加剧,开发高效、可持续的CO2转化技术已成为国际研究的前沿课题。特别是将CO2升级转化为具有高附加值的长链碳氢化合物(C3及以上)不仅有助于缓解温室效应,还为实现碳中和和构建循环经济体系提供了... 随着全球气候变化问题的日益加剧,开发高效、可持续的CO2转化技术已成为国际研究的前沿课题。特别是将CO2升级转化为具有高附加值的长链碳氢化合物(C3及以上)不仅有助于缓解温室效应,还为实现碳中和和构建循环经济体系提供了新路径。在众多技术路线中,电催化与生物催化因其温和的反应条件、良好的可控性和可模块化集成特性,展现出广阔的发展前景。然而,两者在独立应用中分别存在产物选择性差、固碳效率低或系统稳定性不足等瓶颈问题。近年来,电催化与微生物催化的协同耦合策略逐渐成为研究热点。该策略利用电能为微生物固碳过程提供能量和还原力,或通过电催化将CO2还原为C1/C2中间产物(如CO、甲酸、乙酸等),进一步作为碳源被特定微生物利用,通过代谢途径高选择性合成丁醇、己酸、烯烃等多碳产物,实现对CO2的深度转化和资源化利用。根据电化学系统与生物系统在时间、空间及能量耦合方式的不同,该类系统可划分为电-菌原位耦合系统与电-菌异位耦合系统两大类。本文系统梳理了当前电-微生物细胞协同固碳转化合成化学品领域的研究进展,重点分析了不同耦合模式在产物分布调控、电子传递机制、界面构建策略及系统稳定性等方面的技术关键与科学挑战。进一步结合合成生物学、材料科学与反应工程的交叉融合趋势,提出了未来该领域在精准调控、高通量筛选与系统集成等方向的发展前景。本综述为推动电-微生物协同固碳转化技术的深入研究与实际应用提供了重要参考与理论支撑。 展开更多
关键词 电催化 微生物 耦合系统 CO2固定 微生物电合成 胞外电子传递
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基于综合勘探与组合赋权的岩溶发育综合评价 认领 引用
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作者 罗振江 赵振华 +5 位作者 韩琳 李岳恒 孙虹洁 林广奇 白思楚 季孟奇 《高校地质学报》 CAS CSCD 北大核心 2026年第2期244-255,共12页
区域性岩溶发育程度评价可为岩溶地区地质灾害防治和建设规划提供参考依据,传统单一的钻探或物探手段存在局限性,无法整体探明岩溶空间发育特征及分布规律,导致相应地区的工程建设存在较大安全隐患。以济南市莱芜区牛泉镇一处居民建设... 区域性岩溶发育程度评价可为岩溶地区地质灾害防治和建设规划提供参考依据,传统单一的钻探或物探手段存在局限性,无法整体探明岩溶空间发育特征及分布规律,导致相应地区的工程建设存在较大安全隐患。以济南市莱芜区牛泉镇一处居民建设区为例,采用高密度电阻率、微动谱比及电磁波CT开展岩溶特征综合精细物探分析,并基于地质钻孔数据,建立了研究区三维地质结构可视化模型,综合物探解译与三维地质结构模型全面揭示了研究区岩溶发育特征及分布规律。同时,采用改进结构CRITIC主客观组合赋权方法对研究区岩溶发育程度进行了综合评价。结果表明:综合精细勘探方法与基于钻孔数据建立的三维地质结构模型相互补充、结合验证,全面准确揭示研究区地下岩溶的形成位置、总体规模、展布形态、分布范围以及连通性等发育特征和规律;组合赋权提高了评价的客观性和准确性,影响岩溶发育程度的评价指标组合权重由大到小依次为溶洞分布密度、可溶岩分布、土层结构类型、第四系厚度和古近系非可溶岩厚度。研究区可划分岩溶较发育区、一般发育区和不发育区三种类型,分布面积分别为7939.325 m2、17737.1347 m2、和36169.07 m2,岩溶较发育区主要分布在研究区东南方向。文章研究方法和结论可为岩溶区工程建设选址提供参考依据。 展开更多
关键词 岩溶发育 综合精细勘探 三维可视化模型 组合赋权 区划评价
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马的近端籽骨骨折及籽骨炎综述 认领 引用
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作者 韩琳 杜山 +4 位作者 刘凯 马天文 卢爱桃 高瑞峰 张志恒 《东北农业大学学报》 CAS CSCD 北大核心 2026年第1期157-164,共8页
近端籽骨骨折和籽骨炎影响马匹运动性能和健康。文章综述了马匹近端籽骨骨折及籽骨炎的病因、诊断、治疗及预防措施。结果表明,两种疾病发生与多种因素相关,包括运动负荷、病变和炎症等。诊断主要依赖影像学技术,如X射线、超声和MRI。... 近端籽骨骨折和籽骨炎影响马匹运动性能和健康。文章综述了马匹近端籽骨骨折及籽骨炎的病因、诊断、治疗及预防措施。结果表明,两种疾病发生与多种因素相关,包括运动负荷、病变和炎症等。诊断主要依赖影像学技术,如X射线、超声和MRI。在治疗方面,通过限制运动、使用抗炎药物等手段促进愈合,并辅以富血小板血浆疗法等生物治疗方法。预防措施则主要包括加强饲养管理、优化运动训练。深入研究马匹近端籽骨骨折与籽骨炎的发病机制、诊断方法及治疗策略,对提升马匹福利和保障竞技能力具有重要意义。 展开更多
关键词 马 近端籽骨骨折 籽骨炎 诊断 治疗
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NASA 2024-2025年度进展、成果与挑战 认领 引用
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作者 范唯唯 韩淋 +1 位作者 王海名 杨帆 《空间科学学报》 CAS CSCD 北大核心 2026年第3期567-574,共8页
2024-2025年,美国国家航空航天局(NASA)持续推进月球–火星深空探索、空间科学研究、载人航天工程、航空技术创新与商业航天能力建设,在多个关键领域取得重要进展.在深空探索方面,NASA系统推进载人重返月球探索计划,完成多项关键系统测... 2024-2025年,美国国家航空航天局(NASA)持续推进月球–火星深空探索、空间科学研究、载人航天工程、航空技术创新与商业航天能力建设,在多个关键领域取得重要进展.在深空探索方面,NASA系统推进载人重返月球探索计划,完成多项关键系统测试与任务准备,并取得阶段性成果;在空间科学方面,天体生物学、行星防御、日球层物理、空间天文学及对地观测领域持续产出重要科学发现;在近地轨道方面,国际空间站实现连续载人驻留25周年,并加快向商业空间站过渡;在航空与航天技术方面,静音超声速、高超声速及城市空中交通技术不断取得突破.本文系统梳理NASA在2024-2025年取得的主要进展与成果,并简要分析期间NASA经历的预算波动,为理解其未来发展方向提供参考. 展开更多
关键词 NASA年度亮点 载人深空探索 空间科学 近地活动 技术创新
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