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Novel genetic loci regulate flowering time in the northeast soybean germplasm of China 认领 引用
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作者 Javaid Akhter Bhat Hui Yu +7 位作者 Moran Bu Jiantian Leng Beifang Zhao Dongmei Wang Yongliang Li Yeyao Du Suxin Yang Xianzhong Feng 《The Crop Journal》 SCIE CSCD 2026年第3期923-935,共13页
Flowering time is a crucial agronomic trait that affects the adaptability and yield of soybeans.Despite extensive research aimed at uncovering the genetic basis of flowering time in soybean germplasm,investigations in... Flowering time is a crucial agronomic trait that affects the adaptability and yield of soybeans.Despite extensive research aimed at uncovering the genetic basis of flowering time in soybean germplasm,investigations involving the soybean germplasm from Northeast China have been limited.Here,we elucidated the genetic basis of days to flowering(DTF)in the soybean germplasm grown in Northeast China by employing an integrated strategy,including association mapping,quantitative trait locus(QTL)analysis,haplotype analysis,and candidate gene analysis.Overall,the genome-wide association study(GWAS)revealed 15 single-nucleotide polymorphisms(SNPs)significantly linked with DTF across six GWAS models and four individual environments plus a combined environment(CE).Five stable QTL were identified,among which four(viz.,qDTF8,qDTF12,qDTF15.1,and qDTF15.2)are reported for the first time,and the remaining one(qDTF19)was detected in previous studies.On the basis of the findings of expression and haplotype analysis,fourteen putative candidate genes were detected across the genomic intervals of these five QTL.Among these genes,Glyma.19 g197600 and Glyma.19 g200700 were confirmed through both expression and haplotype analysis.Moreover,the relationship of the haplotypes with gene expression indicates that Glyma.19 g197600 is a negative regulator of early flowering,thereby providing evidence of its role in flowering.This study reveals potential genetic loci and genes that could facilitate the expansion of soybean cultivation into regions with short growing seasons and long photoperiodic conditions across the globe. 展开更多
关键词 Soybean Flowering time GWAS QTL Candidate gene Northeast China
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Marine collagen for regenerative medicine:Structure-function advantages,limitations,and translational pathways 认领 引用
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作者 Rui Yuan Wenhui Huang +6 位作者 Heng Liu Juan Wu Hui Yu Xiyuan Zhao Shen Ji Xinhuan Wang Qi Gu 《Bioactive Materials》 SCIE CSCD 2026年第8期428-446,共19页
Marine collagen is emerging as a transformative natural-derived material in regenerative medicine.Unlike traditional mammalian collagen,it has unique structural properties(e.g.,a distinct amino acid profile)that confe... Marine collagen is emerging as a transformative natural-derived material in regenerative medicine.Unlike traditional mammalian collagen,it has unique structural properties(e.g.,a distinct amino acid profile)that confer high biocompatibility and low immunogenicity,along with excellent antibacterial activity and a sus-tainable supply chain that eliminates zoonotic disease risks.This review establishes the foundational rationale for this shift by conducting a comprehensive analysis of the structure-function relationships underpinning the regenerative superiority of marine collagen.We critically evaluate how advanced manufacturing technologies(e.g.,3D bioprinting,electrospinning)leverage these intrinsic properties to deliver transformative therapeutic outcomes,exemplified by biomechanically optimized cartilage scaffolds and immunomodulatory wound matrices.Our review also delineates actionable pathways for clinical translation,addressing challenges in scalability,regulatory compliance,and long-term stability.This review uniquely integrates structure-function relationships with green industrialization pathways,offering an actionable framework for clinical translation of marine collagen,which repositions marine collagen from a mere alternative to an indispensable platform material,poised to drive the next generation of regenerative therapies. 展开更多
关键词 Marine collagen 3D bioprinting Electrospinning Biomedical engineering Clinical application
Ultra-high strength−ductility synergetic improvement mechanism in Mg−8Bi−1Al−1Zn alloy by inverse temperature field ECAP processing 认领 引用
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作者 Shuai-ju MENG Jin-long SONG +6 位作者 Jian-jun ZHANG Hao LIU Jin-qi GUI Hui YU Gui-rong YANG Guang-li BI Yuan-dong LI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第7期2005-2016,共12页
Aiming at developing Mg alloys with good strength and ductility,an inverse temperature field equal channel angular pressing(ITF-ECAP)technique was proposed to realize the severe plastic processing of Mg−8Bi−1Al−1Zn(BA... Aiming at developing Mg alloys with good strength and ductility,an inverse temperature field equal channel angular pressing(ITF-ECAP)technique was proposed to realize the severe plastic processing of Mg−8Bi−1Al−1Zn(BAZ811,wt.%)alloy at low temperature of~80°C.As a result,a microstructure consisting of ultrafine grains having an average grain size(AGS)of~506 nm and fine grains with an AGS of~1.36μm was constructed in BAZ811 alloy through 4-pass ITF-ECAP processing.Additionally,a large amount of nano-sized Mg3Bi2 phase precipitated during ITF-ECAP processing,and the micro-scale Mg3Bi2 particles were greatly refined.Furthermore,the ITF-ECAPed BAZ811 alloy exhibits an ultra-high strength−ductility synergy with yield strength and elongation of(381.5±4.2)MPa and(21.4±1.6)%,respectively.High strength stems from grain boundary,precipitate,and dislocation strengthening;good ductility arises from high intergranular strain coordination and weak texture plasticization. 展开更多
关键词 Mg−Bi alloy equal channel angular pressing microstructure mechanical properties
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Deep Learning for Video Summarization:Systematic Review,Challenges and Opportunities 认领 引用
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作者 Qinghao Yu Zidong Wang +1 位作者 Guoliang Wei Hui Yu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第1期21-42,共22页
The exponential growth of video content has driven significant advancements in video summarization techniques in recent years. Breakthroughs in deep learning have been particularly transformative, enabling more effect... The exponential growth of video content has driven significant advancements in video summarization techniques in recent years. Breakthroughs in deep learning have been particularly transformative, enabling more effective detection of key information and creating new possibilities for video synopsis. To summarize recent progress and accelerate research in this field,this paper provides a comprehensive review of deep learningbased video summarization methods developed over the past decade. We begin by examining the research landscape of video abstraction technologies and identifying core challenges in video summarization. Subsequently, we systematically analyze prevailing deep learning frameworks and methodologies employed in current video summarization systems, offering researchers a clear roadmap of the field's evolution. Unlike previous review works,we first classify research papers based on the structural hierarchy of the video(from frame-level to shot-level to video-level),then further categorize them according to the summary backbone model(feature extraction and spatiotemporal modeling).This approach provides a more systematic and hierarchical organization of the documents. Following this comprehensive review,we summarize the benchmark datasets and evaluation metrics commonly employed in the field. Finally, we analyze persistent challenges and propose insightful directions for future research,providing a forward-looking perspective on video summarization technologies. This systematic literature review is of great reference value to new researchers exploring the fields of deep learning and video summarization. 展开更多
关键词 Benchmark datasets deep learning evaluation protocols video abstraction video summarization video synopsis
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Optimizing the Rice Supply Chain with Blockchain:An Analysis Based on Feng Xingyuan's Theory 认领 引用
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作者 Hui Yu Zhongyu yuan +2 位作者 Xintong Song Yutong Hong Xiaoke Gao 《Journal of Economic Insights》 2025年第2期31-43,共13页
With the application and development of big data technology,blockchain technology has emerged as a key solution for optimizing traditional rice supply chains and ensuring food security,leveraging its traceability and ... With the application and development of big data technology,blockchain technology has emerged as a key solution for optimizing traditional rice supply chains and ensuring food security,leveraging its traceability and anti-counterfeiting features in supply chain applications.This paper analyzes the compatibility and feasibility of blockchain technology with rice supply chains based on Feng Xingyuan’s"Institution-Knowledge-Competition"theory.It proposes a tripartite financial framework,"Commercial NFT Warehouse Receipt Pledging,Cooperative Rice Point Mutual Aid,and Policy-Driven Smart Contract Subsidies",to reduce transaction costs across the entire closed-loop process of contract signing,fulfillment,and breach.Practical case studies validate the"dual-threshold"effect of government subsidy intensity and core node endorsement on technology implementation.Finally,targeted risk prevention strategies are proposed,addressing technical,financial,and institutional risks.The study demonstrates that blockchain technology significantly enhances supply chain node efficiency,with future value further unlocked through measures like technological integration and currency fusion,offering actionable solutions for food security. 展开更多
关键词 Blockchain technology Food security Supply chain traceability Institutional threshold
Lanthanide-guided multi-color controllable composite phosphors with warm white light and multi-channel fluorescence labeling application strategy 认领 引用
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作者 Ya Li Yunxiao Ma +3 位作者 Hui Yu Ming Yang Xiangting Dong Zhijia Lv 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第4期1015-1022,I0002,共8页
Due to the difficulty of luminescence intensity optimization and color control,the research on the regulatable warm white light emitting devices and fluorescent labels for multi-color detection is ongoing.The Ln3+-... Due to the difficulty of luminescence intensity optimization and color control,the research on the regulatable warm white light emitting devices and fluorescent labels for multi-color detection is ongoing.The Ln3+-Bi2(PTA)3/Bi2O3phosphors with rod-shaped structure were prepared by one-step hydrothermal method,and the incorporation of Bi2O3and terephthalic acid(PTA)ligand effectively magnifies the absorption ability for the photons to enhance the emission intensity.The mono lanthanide-doped DyBi2(PTA)3/Bi2O3exhibits pure cool white light,and it can be transformed to warm white light with the codoped Eu3+amount increasing.Eu3+-Tb3+-Bi2(PTA)3/Bi2O3can emit red and green light,which is used as the multi-color fluorescence labeling,and the mixed formed yellow light fills the blank of the yellow lighting device. 展开更多
关键词 Ln3+-Bi2(PTA)3/Bi2O3 Luminescence material Light color adjustable phosphor Warm white emission W-WLEDs Rare earths
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Technical system of electroencephalography-based brain-computer interface:Advances,applications,and challenges 认领 引用
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作者 Hui Yu Qiyue Mu +2 位作者 Chong Liu Shuo Wang Jinglai Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期3885-3907,共23页
Electroencephalography-based brain-computer interfaces have revolutionized the integration of neural signals with technological systems,offering transformative solutions across neuroscience,biomedical engineering,and ... Electroencephalography-based brain-computer interfaces have revolutionized the integration of neural signals with technological systems,offering transformative solutions across neuroscience,biomedical engineering,and clinical practice.This review systematically analyzes advancements in electroencephalography-based brain-computer interface architectures,emphasizing four pillars,namely signal acquisition,paradigm design,decoding algorithms,and diverse applications.The aim is to bridge the gap between technology and application and guide future research.In signal acquisition,noninvasive systems using wet,dry,and semi-dry electrodes are more comfortable and gentler on the skin compared to traditional methods.However,ensuring stable signal quality over long periods of time remains a challenge.Minimally invasive approaches,such as microneedle arrays and endovascular probes,achieve near-invasive signal fidelity without major surgery.Paradigm design explores task-specific neural encoders.Although motor imagery paradigms are widely used in rehabilitation,they require weeks of user training.Steady-state visually evoked potential and P300 speller paradigms enable rapid calibration,but cause visual and cognitive fatigue.Advanced systems currently combine electroencephalography with electromyography or eyetracking to better handle real-world tasks.Decoding algorithms have advanced through Riemannian geometry for improved noise filtering,deep learning architectures for automated spatiotemporal feature extraction,and transfer learning frameworks to minimize cross-subject calibration.However,challenges remain in managing inconsistent electroencephalography,reducing processing demands,and ensuring compatibility across different electroencephalography devices.Clinical trials reveal a predominant focus on stroke rehabilitation,while emerging frontiers include astronaut neuro-monitoring in space exploration.Challenges include improving signal accuracy,minimizing movement interference,addressing ethical data concerns,and ensuring real-world use.Future advancements focus on biocompatible nanomaterials,adaptive algorithms,and multimodal integration,positioning electroencephalography-based brain-computer interfaces as pivotal tools in next-generation neurotechnology. 展开更多
关键词 clinical trial deep learning diagnosis electroencephalography paradigms electrode motor imagery rehabilitation sensor steady-state visually evoked potential transfer learning
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Hilbert Subspace Imprint:a New Mechanism for Non-Thermalization 认领 引用
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作者 Hui Yu Jiangping Hu Shi-Xin Zhang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第7期69-73,I0041-I0049,共5页
The search for non-ergodic mechanisms in quantum many-body systems has become a frontier area of research in non-equilibrium physics.In this work,we introduce Hilbert subspace imprint(HSI)-a new mechanism that enables... The search for non-ergodic mechanisms in quantum many-body systems has become a frontier area of research in non-equilibrium physics.In this work,we introduce Hilbert subspace imprint(HSI)-a new mechanism that enables evasion of thermalization,standing as an independent non-ergodic mechanism alongside quantum many-body scars(QMBS)and Hilbert space fragmentation(HSF).HSI manifests when initial states overlap exclusively with a polynomial scaling(with system size)set of eigenstates.We demonstrate this phenomenon through two distinct approaches:weak symmetry breaking and initial state engineering.In the former case,we observe that ferromagnetic states including those with a single spin-flip display non-thermal behavior under weak U(1)breaking,while antiferromag-netic states thermalize.In contrast,the Z2-symmetric model shows thermalization for both ferromagnetic and antiferromagnetic states.In the latter case,we engineer the initial state prepared by shallow quantum circuits that enhance the overlap with the small target subspace. 展开更多
关键词 hilbert space fragmentation hsf hsi initial states overlap non ergodic mechanisms quantum many body scars evasion thermalizationstanding hilbert subspace imprint hsi quantum many body systems non thermalization
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From bile acids to yes-associated protein:A bidirectional switch for cholangiocarcinoma therapy 认领 引用
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作者 Shu-Yuan Zhang Hui Yu +1 位作者 Yin Mi Fan-Kai Xiao 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第5期1-8,共8页
Cholangiocarcinoma(CCA)is characterized by high invasiveness,early metastasis,and chemotherapy resistance,with a 5-year survival rate persistently below 20%.Current therapies are limited to surgery and a few chemother... Cholangiocarcinoma(CCA)is characterized by high invasiveness,early metastasis,and chemotherapy resistance,with a 5-year survival rate persistently below 20%.Current therapies are limited to surgery and a few chemotherapeutic options,highlighting an urgent need for actionable molecular targets and personalized strategies.In the recent issue of World Journal of Gastrointestinal Oncology,Hu et al report that glycochenodeoxycholic acid activates yes-associated protein(YAP)by inhibiting mammalian Ste20-like kinases/large tumor suppressor kinases(MST/LATS)phosphorylation,thereby promoting proliferation,invasion,and suppressing apoptosis,whereas deoxycholic acid enhances MST/LATS phosphorylation to block YAP nuclear entry,inhibiting tumor growth and inducing apoptosis.Given that the conversion between conjugated and unconjugated bile acids is fundamentally governed by intestinal microbial metabolism,this finding underscores the critical regulatory role of the gut microbiota.YAP modulators can reverse these bile-acid effects in both directions,establishing the“bile acid-Hippo-YAP”axis as an actionable driver.This study is the first to demonstrate the opposing roles of these two bile acids within the same model system,providing a mechanistic basis for CCA heterogeneity and suggesting that identifying bile acid biomarkers,manipulating the gut microbiota-bile acid metabolism or combining YAP-targeted drugs could offer novel strategies to overcome the therapeutic bottleneck in CCA.However,the use of a single cell line,one animal model,and the lack of immune microenvironment data limit generalizability;other bile acid species and cross-talk pathways were not explored.The commentary concludes that future work should further validate these findings. 展开更多
关键词 Bile acids Yes-associated protein Cholangiocarcinoma Gut microbiota Therapeutic targets
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Correlation of mild cognitive impairment with locomotive syndrome in geriatric cancer patients:A cross-sectional study 认领 引用
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作者 Ying Chen Wen-Jing Xu +9 位作者 Hui Lu Jing Wang Ling Li Hui Su Dan-Hua Liang Yu-Qing Zhou Yong-Ping Xu Jing-Fang Xia Hui Yu Yu-Ling Yang 《World Journal of Psychiatry》 SCIE 2026年第4期295-306,共12页
BACKGROUND Locomotive syndrome(LS),a criterion capable of evaluating physical function at an earlier stage,has been less studied in relation to mild cognitive impairment(MCI).Clarifying the correlation between LS stat... BACKGROUND Locomotive syndrome(LS),a criterion capable of evaluating physical function at an earlier stage,has been less studied in relation to mild cognitive impairment(MCI).Clarifying the correlation between LS status and MCI in geriatric cancer patients may aid in identifying early risks for cognitive and motor impairments,providing new insights into maintaining patient independence.AIM To explore risk factors and the correlation between MCI and LS in geriatric cancer patients.METHODS A total of 467 geriatric cancer patients admitted to our hospital from July 2024 to June 2025 were enrolled.MCI was assessed using the Mini Mental State Examination,while locomotive function was evaluated using the Geriatric Locomotive Function Scale-25.Univariate analysis was conducted to evaluate differences in MCI and LS among geriatric cancer patients with different clinical characteristics.Logistic regression was performed to identify independent risk factors.Spearman correlation analysis was employed to assess the relationship between MCI and LS.RESULTS The prevalence of LS was 58.0%,and that of MCI was 30.5%.Logistic regression analysis indicated that age,number of chronic comorbidities,educational level,and MCI were independent risk factors for LS.Age,number of chronic comorbidities,and LS were risk factors for MCI.Spearman correlation analysis revealed a negative correlation between Geriatric Locomotive Function Scale-25 and Mini Mental State Examination scores(r=-0.436,P<0.001).CONCLUSION A significant correlation exists between MCI and LS in geriatric cancer patients.Clinical management and nursing care should concurrently address cognitive impairment and LS to improve patients’overall quality of life and prognosis. 展开更多
关键词 Geriatric cancer patients Locomotive syndrome Cognitive impairment Musculoskeletal function Correlation
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A Comprehensive Literature Review on YOLO-Based Small Object Detection:Methods,Challenges,and Future Trends 认领 引用
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作者 Hui Yu Jun Liu Mingwei Lin 《Computers, Materials & Continua》 SCIE EI 2026年第4期258-309,共52页
Small object detection has been a focus of attention since the emergence of deep learning-based object detection.Although classical object detection frameworks have made significant contributions to the development of... Small object detection has been a focus of attention since the emergence of deep learning-based object detection.Although classical object detection frameworks have made significant contributions to the development of object detection,there are still many issues to be resolved in detecting small objects due to the inherent complexity and diversity of real-world visual scenes.In particular,the YOLO(You Only Look Once)series of detection models,renowned for their real-time performance,have undergone numerous adaptations aimed at improving the detection of small targets.In this survey,we summarize the state-of-the-art YOLO-based small object detection methods.This review presents a systematic categorization of YOLO-based approaches for small-object detection,organized into four methodological avenues,namely attention-based feature enhancement,detection-head optimization,loss function,and multi-scale feature fusion strategies.We then examine the principal challenges addressed by each category.Finally,we analyze the performance of thesemethods on public benchmarks and,by comparing current approaches,identify limitations and outline directions for future research. 展开更多
关键词 Small object detection YOLO real-time detection feature fusion deep learning
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TIE1 is a potential target for hypertension-related atrial fibrillation 认领 引用
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作者 Hui Yu Longfei Hao +2 位作者 Rui Wang Yongtai Gong Yue Li 《Frigid Zone Medicine》 2026年第2期86-96,I0061-I0066,共11页
Objective:Cardiovascular diseases pose a major public health challenge in China,particularly in northern frigid regions where environmental stressors and limited access to healthcare access exacerbate disease risk.Bot... Objective:Cardiovascular diseases pose a major public health challenge in China,particularly in northern frigid regions where environmental stressors and limited access to healthcare access exacerbate disease risk.Both atrial fibrillation(AF)and hypertension are influenced by cold exposure.AF is a frequent cardiovascular complication of hypertension,yet their causal relationship remains incompletely defined.This study aimed to elucidate the mechanisms linking hypertension to AF in frigid regions,with an emphasis on identifying key genes driving disease progression.Methods:We analyzed clinical data from 29,786 patients hospitalized at the First Affiliated Hospital of Harbin Medical University.Multivariate logistic regression was used to assess the association between hypertension and AF,and Mendelian randomization(MR)analyses were performed using genome-wide association study(GWAS)datasets.Wholeblood expression quantitative trait locus(eQTL)analysis and pathway enrichment were applied to identify hypertension-related genes.Singlecell RNA sequencing data from AF patients and hypertensive rat models were used to validate the role of TIE1.In addition,gut microbiota GWAS data were integrated to explore microbial influences on hypertension.Results:Hypertension emerged as both an independent and causal risk factor for AF in frigid regions.Gene expression analyses identified TIE1 as a central mediator of hypertension-related effects,with elevated cardiomyocyte TIE1 expression associated with increased susceptibility to AF.In hypertensive rats,increased TIE1 expression correlated with higher AF incidence and enhanced inflammatory cytokine production,whereas cardiomyocyte-specific TIE1 knockdown reduced AF occurrence and attenuated atrial remodeling.Gut microbiota analysis further revealed that the abundance of Adlercreutzia was inversely correlated with TIE1 expression,suggesting a potential protective role mediated through microbial regulation of host gene expression.Conclusion:These findings establish a causal link between hypertension and AF in cold northern regions and identify TIE1 as a pivotal mediator of this association.Targeting TIE1 may represent a therapeutic strategy for hypertension-associated AF.Moreover,the identification of Adlercreutzia as a modulator of TIE1 underscores the potential of the gut microbiota in preventing cardiovascular complications in frigid regions and opens promising avenues for future interventions. 展开更多
关键词 cold regions tie atrial fibrillation Mendelian randomization cardiovascular diseases gut microbiota gene expression atrial fibrillation af
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3-甲基腺嘌呤通过NF-κB/BCL-2通路调控肝星状细胞自噬与凋亡的实验研究 认领 引用
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作者 惠瑜 任丽娟 +1 位作者 朱鹏银 陈倩 《热带医学杂志》 CAS 2026年第1期23-28,F0003,共6页
目的探究3-甲基腺嘌呤(3-MA)对肝星状细胞(HSCs)活化、自噬、凋亡及核转录因子(NF-κB)信号通路的影响,解析其交互调控机制。方法采用转化生长因子-β(TGF-β)干预构建HSCs模型,经吉姆萨染色进行细胞凋亡形态学观察。使用3-MA、NF-κB... 目的探究3-甲基腺嘌呤(3-MA)对肝星状细胞(HSCs)活化、自噬、凋亡及核转录因子(NF-κB)信号通路的影响,解析其交互调控机制。方法采用转化生长因子-β(TGF-β)干预构建HSCs模型,经吉姆萨染色进行细胞凋亡形态学观察。使用3-MA、NF-κB抑制剂、NF-κB诱导剂对HSC-T6细胞进行干预,采用CCK-8法检测细胞活力确定干预剂量,并设置空白组(未处理)、TGF-β(2 ng/mL)+磷酸缓冲盐溶液(PBS)组、TGF-β(2 ng/mL)+3-MA(0.5 mg/mL)组、TGF-β(2 ng/mL)+易位抑制剂多肽SN50(SN50)(80µg/mL)组、TGF-β(2 ng/mL)+3-MA(0.5 mg/mL)+丙二醇甲醚醋酸酯(PMA)(60 ng/mL)组。通过实时荧光定量逆转录聚合酶链式反应(RT-PCR)及蛋白质免疫印迹(Western blot)技术,系统检测肝星状细胞活化标志物α-平滑肌肌动蛋白(α-SMA)、自噬标志物微管相关蛋白1轻链3B(LC3B)、重组人自噬效应蛋白(Beclin-1)、抗凋亡蛋白B细胞淋巴瘤-2(BCL-2)及NF-κB p65亚基(NF-κB p65)的基因与蛋白表达水平,以解析自噬-凋亡调控网络在HSCs活化中的分子作用机制。结果CCK-8法测定显示,3-MA、SN50、PMA诱导的HSC-T6细胞的保护浓度分别为0.5 mg/mL、80µg/mL和60 ng/mL。吉姆萨染色显示,TGF-β作用48 h细胞形态不规则、突起增多、胞质浓缩,经3-MA处理后细胞体积增大,胞质颗粒增多,细胞间隙正常。在mRNA水平上,各实验组α-SMA、LC3B、Beclin-1、BCL-2及NF-κB p65 mRNA水平比较,差异均有统计学意义(F=356.142、484.230、187.027、1035.708、500.228,P均<0.05)。与TGF-β+PBS组比较,除TGF-β+3MA+PMA组α-SMA mRNA外,其余各实验组α-SMA、LC3B、Beclin-1、BCL-2及NF-κB p65 mRNA水平显著降低,差异均有统计学意义(P均<0.05);与TGF-β+3-MA组比较,各实验组LC3B、Beclin-1、BCL-2 mRNA水平升高,TGF-β+3-MA+PMA组NF-κB p65 mRNA水平上调,差异均有统计学意义(P均<0.05)。蛋白表达分析显示,各组α-SMA、LC3B、Beclin-1、BCL-2及NF-κB p65蛋白表达水平差异均有统计学意义(F=50.215、210.972、168.200、30.309、241.205,P均<0.05)。各实验组α-SMA、LC3B、BCL-2蛋白水平均高于空白组,差异均有统计学意义(P均<0.05);与TGF-β+PBS组比较,各实验组LC3B、Beclin-1、NF-κB p65蛋白水平下调(P均<0.05),除TGF-β+3-MA+PMA组外,其余各实验组的α-SMA、BCL-2水平下调(P均<0.05),差异均有统计学意义;与TGF-β+3-MA组比较,TGF-β+SN50组LC3B、Beclin-1水平上调,NF-κB p65水平显著降低(P均<0.05),TGF-β+3-MA+PMA组的α-SMA、Beclin-1、BCL-2水平升高(P均<0.05),差异均有统计学意义。结论3-MA通过调控NF-κB/BCL-2信号通路,干预HSC-T6细胞活性,为肝纤维化治疗提供新理论依据和潜在靶点。 展开更多
关键词 3-甲基腺嘌呤 肝星状细胞 自噬 凋亡 NF-κB信号通路
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Extreme Impacts of Four Landfalling Tropical Cyclones in China during the 2024 Peak Season 认领 引用 被引量：4
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作者 Liguang WU Runling YU +3 位作者 Chunyi XIANG Hui YU Yecheng FENG Xingyang ZHOU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2025年第5期817-824,共8页
Extreme weather events have been identified as the top global risk for the upcoming decade,according to the Global Risk Report 2025.Between July and September 2024,four tropical cyclones with extreme characteristics m... Extreme weather events have been identified as the top global risk for the upcoming decade,according to the Global Risk Report 2025.Between July and September 2024,four tropical cyclones with extreme characteristics made landfall in China,highlighting the potential impacts of climate change on tropical cyclone activity.Super Typhoon Gaemi made landfall in Taiwan and Fujian provinces,setting record-breaking daily rainfall at 14 meteorological stations in Jiangxi,Hunan,and Liaoning provinces.As the strongest typhoon to make landfall in China during autumn,Yagi maintained super typhoon intensity when making landfall in Hainan,Guangdong provinces in China,and Quang Ninh Province in Vietnam.Typhoon Bebinca and Tropical Storm Pulasan made consecutive landfalls in Shanghai within four days,with Bebinca being the strongest typhoon to strike Shanghai and Jiangsu Province since 1949.The World Weather Attribution report indicates that,due to climate change,rainfall events like those from Super Typhoon Gaemi have become more frequent,now occurring every 20 years in the northern Philippines,every 5 years in Taiwan Province,and every 100 years in Hunan Province.In Taiwan and Hunan provinces,climate change has increased rainfall by 14%and 9%,respectively.It is suggested that exploring how climate change influences the extreme events of landfalling typhoons is an important area for future research. 展开更多
关键词 typhoon climate change extreme weather events typhoon precipitation
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Experimental and numerical studies on rock damage law in straight-hole cut blasting under biaxial confining pressure 认领 引用 被引量：3
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作者 Xiantang Zhang Zhaobin Li +4 位作者 Hui Yu Hongmin Zhou Hongli Wang Xiangtuan Jiao Fuzhi Wang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2025年第9期1529-1541,共13页
To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting,tests were performed under different confining pressures.Th... To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting,tests were performed under different confining pressures.Then,the characteristics of rock mass crack development were analyzed,and the pressure resistance values of core samples before and after blasting were compared to study the trends of rock mass damage.Moreover,a three-dimensional numerical simulation model was established by LS-DYNA to analyze the stress wave propagation,cavity shape and crack propagation characteristics under different confining pressures.The propagation of rock blasting cracks is negatively correlated with the confining pressure.The greater the confining pressure,the shorter the crack development time.Additionally,the crack width is reduced from 0.4-1.7 to 0.04-1.4 mm,and the length is shortened from 280 to 120 mm.A comparison of the compressive strength revealed that blasting reduces the compressive strength of the rock mass.The greater the distance from the explosion source,the lower the degree of strength attenuation.An increase in the confining pressure can inhibit strength attenuation.Numerical simulations revealed that under the same confining pressure,the stress first peaks at the bottom of the blast hole.The greater the confining pressure,the longer the stress peak duration,the smaller the cavity volume,and the shorter the crack propagation length and depth.Under a confining pressure of 4 MPa,the longest crack was only 154.5 mm in length and 102 mm in depth.The research results provide a scientific basis for controlling rock damage and optimizing design in the excavation of deep rock roadways by blasting. 展开更多
关键词 Biaxial confining pressure Straight-hole cut blasting Exploded stress wave Crack growth Rock damage
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Electrochemical behavior and discharge performance of as-rolled precipitate-free Mg-Sn alloy as anode for Mg-air batteries 认领 引用 被引量：2
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作者 Xu LI Wei-li CHENG +7 位作者 Jian LI Fei-er SHANGGUAN Hui YU Li-fei WANG Hang LI Hong-xia WANG Jin-hui WANG Hua HOU 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2025年第3期832-848,共17页
A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anod... A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm2,reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm2.This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture. 展开更多
关键词 Mg-air battery Mg-Sn anode grain structure electrochemical behavior discharge performance
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Self-Cumulative Contrastive Graph Clustering 认领 引用 被引量：2
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作者 Xiaoqiang Yan Kun Deng +2 位作者 Quan Zou Zhen Tian Hui Yu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2025年第6期1194-1208,共15页
Contrastive graph clustering(CGC)has become a prominent method for self-supervised representation learning by contrasting augmented graph data pairs.However,the performance of CGC methods critically depends on the cho... Contrastive graph clustering(CGC)has become a prominent method for self-supervised representation learning by contrasting augmented graph data pairs.However,the performance of CGC methods critically depends on the choice of data augmentation,which usually limits the capacity of network generalization.Besides,most existing methods characterize positive and negative samples based on the nodes themselves,ignoring the influence of neighbors with different hop numbers on the node.In this study,a novel self-cumulative contrastive graph clustering(SC-CGC)method is devised,which is capable of dynamically adjusting the influence of neighbors with different hops.Our intuition is that better neighbors are closer and distant ones are further away in their feature space,thus we can perform neighbor contrasting without data augmentation.To be specific,SC-CGC relies on two neural networks,i.e.,autoencoder network(AE)and graph autoencoder network(GAE),to encode the node information and graph structure,respectively.To make these two networks interact and learn from each other,a dynamic fusion mechanism is devised to transfer the knowledge learned by AE to the corresponding GAE layer by layer.Then,a self-cumulative contrastive loss function is designed to characterize the structural information by dynamically accumulating the influence of the nodes with different hops.Finally,our approach simultaneously refines the representation learning and clustering assignments in a self-supervised manner.Extensive experiments on 8 realistic datasets demonstrate that SC-CGC consistently performs better over SOTA techniques.The code is available at http://gffzz188fe103f8f1460asofbb0pu5xcxk6xbx.ffgz.tsg.suse.edu.cn/Xiaoqiang-Yan/JAS-SCCGC. 展开更多
关键词 Dynamic fusion mechanism graph clustering selfcumulative contrastive learning self-supervised clustering
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Revealing the intrinsic connection between residual strain distribution and dissolution mode in Mg-Sc-Y-Ag anode for Mg-air battery 认领 引用 被引量：1
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作者 Wei-li Cheng Xu-bang Hao +4 位作者 Jin-hui Wang Hui Yu Li-fei Wang Ze-qin Cui Cheng Chang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2025年第3期1020-1033,共14页
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci... The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g-1)and energy density(1960.42 mW h g-1).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment. 展开更多
关键词 Mg-air batteries Anode Residual strain distribution Dissolution mode Discharge mechanism
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Effects of dislocation loop on microstructure and mechanical properties of LN2-quenched 2524 Al alloy 认领 引用 被引量：1
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作者 Hui YU Li-ping TIAN +6 位作者 Li-wei QUAN Chao LIU Li-xin HUANG Yu-ling XU Wei YU Bin-an JIANG Kwang-seon SHIN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2025年第9期2822-2829,共8页
The microstructure and mechanical properties of 2524 Al alloy after quenching in liquid nitrogen(LN2)were investigated by TEM and compared with those of cold water quenching.The results show that the LN2 quenchi... The microstructure and mechanical properties of 2524 Al alloy after quenching in liquid nitrogen(LN2)were investigated by TEM and compared with those of cold water quenching.The results show that the LN2 quenching process effectively induces the formation of dislocation loops.These loops become large and unevenly distribute after aging for 15 min.Furthermore,such loops become rapidly immobilized by the precipitation of coarse S phases after 1 h aging.The alloy quenched in LN2 demonstrates superior peak hardness and displays a more rapid response to subsequent aging treatments compared with the cold water-quenched one.Despite the short aging time,LN2-quenched sample achieves tensile strength of 488 MPa.This enhanced strength is attributed to the strengthening effect of numerous finely dispersed Guinier-Preston-Bagaryatsky(GPB)zones,in conjunction with the inhomogeneous formation of S phase on the dislocation loops. 展开更多
关键词 2524 Al alloy LN2quenching dislocation loop GPB zone S phase
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Impact of scandium on the microstructure,mechanical properties,corrosion behaviors and in-vitro biocompatibility of a Zn-0.1Li alloy 认领 引用 被引量：1
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作者 He Huang Gencheng Gong +9 位作者 Hui Yu Zhipei Tong Qinggong Jia Liudang Fang Shaokang Guan Jing-Jun Nie DaFu Chen Jing Bai Dong Bian Yufeng Zheng 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第26期235-251,共17页
The poor mechanical properties of pure zinc(Zn)restrain its applications in orthopedics,which requires high loading capacity.Alloying with lithium(Li)element can enhance strength,however,the work-hardening rate is imp... The poor mechanical properties of pure zinc(Zn)restrain its applications in orthopedics,which requires high loading capacity.Alloying with lithium(Li)element can enhance strength,however,the work-hardening rate is impaired with increased Li content.Here,introducing scandium(Sc)into a low Li-containing Zn-0.1Li alloy could effectively refine its microstructure,reducing the average grain size from 10 to 4μm.The refinement in microstructure led to a significant improvement in tensile strength,im-proving from 257 MPa of Zn-0.1Li to 341 MPa of Zn-0.1Li-0.1Sc,meanwhile,the work-hardening rate remained positive during the whole plastic deformation stage.The addition of Sc-impaired elongation is due to numerous microcracks formed at the Zn/ScZn12interfaces,as well as in the large-sized ScZn12particles.Corrosion tests revealed an accelerated corrosion rate due to the galvanic effect between the Zn matrix and ScZn12phase.Even so,the Zn-0.1Li-1.0Sc alloy still exhibited superior biocompatibility with rat/mouse mesenchymal stem cells and close osteogenesis capacity to the original Zn-0.1Li alloy.These findings demonstrated that the addition of Sc in low Li-containing alloys could improve mechanical strength without sacrificing the work-hardening rate and biocompatibility. 展开更多
关键词 Biodegradable zinc Strengthening mechanism Localized corrosion Biocompatibility ScZn12phase
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