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Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing 认领 引用
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作者 Kexin Zhang Wenmin Zhang +4 位作者 Heng An Zhe Huang Yanzhen Wen Xiangyu Jiao Yongqiang Wen 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第4期156-164,共9页
Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellul... Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellular spheroids,their therapeutic effect is enhanced.However,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid therapy.In this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous freeze-drying.Using thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable cytocompatibility.Through the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound sites.Most importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound healing.The NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing. 展开更多
关键词 Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing
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Investigation of single event effect in 28-nm system-on-chip with multi patterns 认领 引用 被引量：5
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作者 Wei-Tao Yang Yong-Hong Li +8 位作者 Ya-Xin Guo Hao-Yu Zhao Yang Li Pei Li Chao-Hui He Gang Guo Jie Liu Sheng-Sheng Yang Heng An 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第10期573-577,共5页
Single event effects (SEEs) in a 28-nm system-on-chip (SoC) were assessed using heavy ion irradiations, and susceptibilities in different processor configurations with data accessing patterns were investigated. The pa... Single event effects (SEEs) in a 28-nm system-on-chip (SoC) were assessed using heavy ion irradiations, and susceptibilities in different processor configurations with data accessing patterns were investigated. The patterns included the sole processor (SP) and asymmetric multiprocessing (AMP) patterns with static and dynamic data accessing. Single event upset (SEU) cross sections in static accessing can be more than twice as high as those of the dynamic accessing, and processor configuration pattern is not a critical factor for the SEU cross sections. Cross section interval of upset events was evaluated and the soft error rates in aerospace environment were predicted for the SoC. The tests also indicated that ultra-high linear energy transfer (LET) particle can cause exception currents in the 28-nm SoC, and some even are lower than the normal case. 展开更多
关键词 system-on-chip heavy ion single event effect
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An Asymmetric Natural Nanofiber with Rapid Temperature Responsive Detachability Inspired by Andrias davidianus for Full‑Thickness Skin Wound Healing 认领 引用 被引量：5
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作者 Zhe Huang Heng An +4 位作者 Haitao Guo Shen Ji Qi Gu Zhen Gu Yongqiang Wen 《Advanced Fiber Materials》 SCIE EI CAS 2024年第2期473-488,共16页
Wound dressing management is critical in healthcare,and frequent dressing changes for full-thickness skin wounds can hinder healing.Nanofiber dressings that resemble the extracellular matrix,have gained popularity in ... Wound dressing management is critical in healthcare,and frequent dressing changes for full-thickness skin wounds can hinder healing.Nanofiber dressings that resemble the extracellular matrix,have gained popularity in wound repair,however,it is challenging to explore how to frequently change it without affecting healing processing and avoiding secondary damage.Here,we developed a self-adhesive and detachable nanofiber dressing inspired by Andrias davidianus.Our asymmetric nanofiber dressing exhibits strong adhesion(26 kPa),to the wound at high temperature(approximately 25°C)to the wound surface and can be easily detached(4 kPa)at low temperature(below 8°C),enabling painless dressing changes that minimize secondary injuries.The dressing comprises an outer layer of polylactic acid which provides mechanical property,support,and pollution resistance,with an inner layer of nanofibrous membrane,composed of gelatin and Andrias davidianus skin secretions,which promotes cellular migration,enhances wound healing and possesses inherent antimicrobial properties.Furthermore,the all-natural nanofiber dressings can be prepared on a large scale and offer favorable biocompatibility to meet the basic requirements of wound dressings.These findings demonstrate the potential applicability of our multilayer nanofiber dressing for advancing wound healing practices. 展开更多
关键词 Natural Rapid Temperature Responsive Detachability Asymmetric Nanofibers Bionic Wound Healing
Design of readout electronics based on peak-holding circuit and multiplexer for a fast neutron spectrometer 认领 引用 被引量：1
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作者 Liyang Sun Kai Zhuang +17 位作者 Xiaoming Wang Fanjian Zeng Heng An Daowu Li Yuxiong Xue Zhiming Zhang Wei Zhou Yingjie Wang Baotong Feng Peilin Wang Xiaohui Li Jiale Cai Teng Tong Fanhui Meng Junguang Zhou Huan Huang Xuanhou Hu Xiubo Qin 《Radiation Detection Technology and Methods》 2018年第1期38-48,共11页
Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace a... Background Fast neutron detection is meaningful in many research fields such as space environment monitoring.A scintillating fiber array model for fast neutron detection was proposed and developed in 1980s.Aerospace applications of the model require electronics in small size.Purpose To design a dedicated electronic system to readout and process the 384-channel signals from scintillating fiber array,and to use the designed system to fabricate a neutron detector for aerospace applications.Methods With the method of nuclear recoil,fast neutron is detected by tracking recoil proton of n–p scatter in scintillating plastic fibers.Using the peak-holding circuits and multiplexers,the system size and power consumption were reduced.Results The detector fabricated with the designed system,had 34 cm×34 cm×27 cm mechanical size,20.4 kg weight,and 30.05W power consumption.Comparing to traditional waveform sampling electronics,the designed electronics was highly integrated and had a small size.The readout electronics also gave a better energy resolution of 39%in neutron detection,while the energy resolution was 43%in previous version.Conclusion In this study,a highly integrated readout electronic system was designed and verified.The detector using the system gave good performance.The designed electronics had potential development in fast neutron detection and other high energy physics detection system. 展开更多
关键词 Multiplexer Peak-holding circuit Readout electronics Fast neutron detection
Development of a fast neutron spectrometer based on a plastic fiber array 认领 引用
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作者 Fan-Jian Zeng Li-Yang Sun +10 位作者 Kai Zhuang Heng An Yu-Xiong Xue Xiao-Ming Wang Dao-Wu Li Zhi-Ming Zhang Bao-Tong Feng Pei-Lin Wang Jia-Le Cai Xiu-Bo Qin De-Tian Li 《Radiation Detection Technology and Methods》 2017年第2期1-8,共8页
Objective A three-dimensional position-sensitive fast neutron spectrometer is designed to measure fast neutron spectrum over 10 MeV.Methods The detector consists of a 16×16 mutually perpendicular plastic scintill... Objective A three-dimensional position-sensitive fast neutron spectrometer is designed to measure fast neutron spectrum over 10 MeV.Methods The detector consists of a 16×16 mutually perpendicular plastic scintillation fiber array coupled to 2×2 Hamamatsu H8500C position-sensitive photomultiplier tubes by optical fibers.The fiber array is fabricated with 0.5 mm×3 mm fibers and 3-mm square fibers.Results Due to the combined application of different sizes of fibers,the detector can broaden energy dynamic range and meanwhile have good detection efficiency.The method of the combined application of different sizes of plastic fibers in the array may provide a solution to measure wider energy range of solar neutrons.Conclusion In this paper,we used FLUKA to simulate the performance of the detector model and report the results of experimental studies with neutrons from a pulsed D-T neutron. 展开更多
关键词 Fast neutron Different sizes Fiber array Energy range
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