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Prolonged consumption of white beer increases levels of short-chain fatty acids and Prevotellaceae bacteria in mice 认领 引用
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作者 Zhaoxi Liu Yongheng Rong +5 位作者 Shuxia Huang Hua Yin Lushan Wang Shumin Hu Junhong Yu Min Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期67-79,共13页
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as... Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research. 展开更多
关键词 Gut microbiota Beer Cytokine Short-chain fatty acids White beer Prevotellaceae
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Simultaneous removal of As(Ⅲ) and Cu(Ⅱ) by biochar modified siderite:The key roles of ROS and mineral conversion 认领 引用
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作者 Kejia Lou Hua Yin +3 位作者 Yuhao Cai Caiya Yan Yibo Yuan Xiaofang Ouyang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期385-394,共10页
Mine drainage frequently contained arsenite(As(Ⅲ)) and copper(Cu(Ⅱ)), posing significant threats to human health. Herein, we developed a novel composite, crab shell biochar modified siderite(SID@BC) for the simultan... Mine drainage frequently contained arsenite(As(Ⅲ)) and copper(Cu(Ⅱ)), posing significant threats to human health. Herein, we developed a novel composite, crab shell biochar modified siderite(SID@BC) for the simultaneous removal of As(Ⅲ) and Cu(Ⅱ). The results revealed that the incorporation of BC into the siderite(SID)significantly increased the adsorption sites and improved the electrochemical properties of SID@BC, thereby enhancing the adsorption capacity of SID@BC for As(Ⅲ) and Cu(Ⅱ), which was 1.3 and 4.2 times higher than that of SID, respectively. Notably, in the process of removing As(Ⅲ) and Cu(Ⅱ), co-existed Cu(Ⅱ) enhanced the transformation of iron phases from siderite to goethite and facilitated the Fe(Ⅱ)/Fe(Ⅲ) cycling. During this cycling process, Fe(Ⅲ) was reduced to Fe(Ⅱ), which subsequently reacted with oxygen to generate additional reactive oxygen species(ROS). Quenching experiments confirmed that O2·- and H2O2 were the key ROS responsible for the oxidation of As(Ⅲ) to As(V), which was more easily electrostatically attracted and complexed. Besides, BC enhanced the Cu(Ⅱ) adsorption performance of SID@BC through mineral precipitation and complexation, which further facilitated the participation of Cu(Ⅱ) in the Fe(Ⅱ)/Fe(Ⅲ) cycle, thereby promoting the ROS generation.These findings provided insight into developing an effective strategy for the simultaneous removal of As(Ⅲ) and Cu(Ⅱ) from wastewater. 展开更多
关键词 Biochar modified siderite Trivalent arsenic Copper Adsorption Oxidation
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Exosomal miR-181d-5p promotes spinal cord injury repair by driving microglial polarization from M1 to M2 phenotype 认领 引用
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作者 Wei Wang Bin Wang Hua Yin 《World Journal of Stem Cells》 SCIE 2026年第7期139-152,共14页
BACKGROUND Spinal cord injury(SCI)is a severe neurological condition characterized by limited treatment options and an unfavorable prognosis.Mesenchymal stem cell(MSC)-derived exosomes constitute a novel cell-free the... BACKGROUND Spinal cord injury(SCI)is a severe neurological condition characterized by limited treatment options and an unfavorable prognosis.Mesenchymal stem cell(MSC)-derived exosomes constitute a novel cell-free therapeutic modality;however,the underlying mechanisms,particularly the role of microRNAs(miRNAs),remain to be fully elucidated.AIM To determine whether MSC-derived exosomes facilitate functional recovery following SCI by regulating microglial polarization through the delivery of miR-181d-5p.METHODS In vitro,primary microglia stimulated with lipopolysaccharide were treated with characterized MSC-derived exosomes.Microglial polarization was assessed using quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay.In vivo,a rat model of SCI was administered exosomes,and functional recovery was evaluated using Basso,Beattie,and Bresnahan scoring,hematoxylin and eosin staining,enzyme-linked immunosorbent assay,and immunofluorescence analysis.RESULTS MSC-derived exosomes displayed characteristic morphological features and surface markers.In lipopolysaccharide-activated microglia,exosome treatment resulted in a significant reduction in pro-inflammatory cytokines and an increase in anti-inflammatory factors,reflecting a shift from the M1 to the M2 microglial phenotype.Notably,miR-181d-5p was upregulated in microglia following exosome treatment.Downregulation of miR-181d-5p abolished the exosome-mediated effects on microglial polarization.Mechanistically,miR-181d-5p was identified to directly bind to the 3’untranslated regions of HMGA2 and HMGB2,thereby repressing their expression.In vivo,administration of MSC-exosomes improved locomotor recovery,reduced inflammatory cytokine levels,and modulated microglial/macrophage polarization,as evidenced by reduced CD86(M1 marker)and elevated CD206(M2 marker)expression at the lesion site.CONCLUSION MSC-derived exosomes attenuate neuroinflammation and promote functional recovery after SCI by delivering miR-181d-5p,which induces a beneficial microglial M2 polarization through targeting HMGA2 and HMGB2.These findings underscore the therapeutic promise of exosomal miR-181d-5p for SCI repair. 展开更多
关键词 Spinal cord injury Exosomes miR-181d-5p M1 phenotype M2 phenotype Neuroinflammation
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Remediation performance and mechanisms of Cu and Cd contaminated water and soil using Mn/Al-layered double oxide-loaded biochar 认领 引用 被引量：9
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作者 Pengcheng Lin Hang Liu +3 位作者 Hua Yin Minghan Zhu Haoyu Luo Zhi Dang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第3期593-602,共10页
The combined pollution of heavy metals is ubiquitous worldwide.Mn/Al-layered double oxide-loaded crab shells biochar (LDO/BC) was prepared,so as to remediate the combined pollution of Cd and Cu in soil and water.The p... The combined pollution of heavy metals is ubiquitous worldwide.Mn/Al-layered double oxide-loaded crab shells biochar (LDO/BC) was prepared,so as to remediate the combined pollution of Cd and Cu in soil and water.The pristine and used LDO/BC were characterized and the results revealed that the layered double oxide was successfully loaded on crab shells biochar (BC) and metal element Ca in crab shells was beneficial to the formation of more regular layered and flake structure.The maximal adsorption capacity (Qm) of LDO/BC for aqueous Cu2+and Cd2+was 66.23 and 73.47 mg/g,respectively.LDO/BC and BC were used to remediate e-waste-contaminated soil for the first time and exhibited highly efficient performance.The extraction amount of Cu and Cd in the contaminated soil by diethylene triamine penta-acetic acid (DTPA) after treating with 5% LDO/BC was significantly reduced from 819.84 to 205.95 mg/kg (with passivation rate 74.8%) and 8.46 to 4.16 mg/kg(with passivation rate 50.8%),respectively,inferring that the bioavailability of heavy metals declined remarkably.The experimental result also suggested that after remediation by LDO/BC the exchangeable and weak acid soluble Cu and Cd in soil translated to reducible,residual and oxidizable fraction which are more stable state.Precipitation,complexation and ion exchange were proposed as the possible mechanisms for Cd and Cu removal.In general,these experiment results indicate that LDO/BC can be a potentially effective reagent for remediation of heavy metal contaminated water and soil. 展开更多
关键词 Mn/Al-layered double oxide Biochar Cd and Cu combined pollution Adsorption Soil remediation
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Remediation of Cu and As contaminated water and soil utilizing biochar supported layered double hydroxide:Mechanisms and soil environment altering 认领 引用 被引量：7
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作者 Pengling Shao Hua Yin +4 位作者 Yingchao Li Yuhao Cai Caiya Yan Yibo Yuan Zhi Dang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第4期275-286,共12页
Preparing materials for simultaneous remediation of anionic and cationic heavy metals contamination has always been the focus of research. Herein a biochar supported FeMnMg layered double hydroxide(LDH) composites(LB)... Preparing materials for simultaneous remediation of anionic and cationic heavy metals contamination has always been the focus of research. Herein a biochar supported FeMnMg layered double hydroxide(LDH) composites(LB) for simultaneous remediation of copper and arsenic contamination in water and soil has been assembled by a facile co-precipitation approach. Both adsorption isotherm and kinetics studies of heavy metals removal by LB were applied to look into the adsorption performance of adsorbents in water. Moreover, the adsorption mechanisms of Cu and As by LB were investigated, showing that Cu in aqueous solution was removed by the isomorphic substitution, precipitation and electrostatic adsorption while As was removed by complexation. In addition, the availability of Cu and As in the soil incubation experiments was reduced by 35.54%–63.00% and 8.39%–29.04%, respectively by using LB. Meanwhile, the addition of LB increased the activities of urease and sucrase by 93.78%–374.35% and 84.35%–520.04%, respectively, of which 1% of the dosage was the best. A phenomenon was found that the richness and structure of microbial community became vigorous within 1% dosage of LB, which indirectly enhanced the passivation and stabilization of heavy metals. These results indicated that the soil environment was significantly improved by LB. This research demonstrates that LB would be an imaginably forceful material for the remediation of anionic and cationic heavy metals in contaminated water and soil. 展开更多
关键词 Heavy metal Biochar supported layered double hydroxide composite Adsorption mechanism Soil remediation Microbial community
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A systematic review of the effectiveness of clinical nurse specialist interventions in patients with chronic obstructive pulmonary disease(COPD) 认领 引用 被引量：2
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作者 Hua Yin Ling Yang Qiao Ye 《Frontiers of Nursing》 2018年第2期147-156,共10页
Objective： This review aimed to examine the effectiveness of clinical nurse specialist （CNS） interventions in patients with chronic obstructive pulmonary disease （COPD）. COPD significantly affects people＇s healt... Objective： This review aimed to examine the effectiveness of clinical nurse specialist （CNS） interventions in patients with chronic obstructive pulmonary disease （COPD）. COPD significantly affects people＇s health worldwide. With the development in nursing, CNSs are playing increasingly important roles in different departments. However, the studies on the effectiveness of CNSs in COPD are not as well organized as the studies on the effectiveness of CNSs in bronchiectasis and asthma. Therefore, this review aims to find some updated evidence on the CNS interventions for patients with COPD and on whether these interventions are effective.Methods： A narrative analysis of the data was performed for the eligible studies. Four databases were chosen： CINAHL, MEDLINE, British Nursing Index, and Cochrane Library. Other websites such as the National Institute for Health and Clinical Excellence, National Health Service Evidence, Association of Respiratory Nurse Specialists, and National Association of Clinical Nurse Specialist were searched as well. Two reviewers performed study identification independently, and all the retrieved articles were stored using the EndNote X7 software. The risk of bias in the included studies was assessed using the Cochrane Collaboration＇s risk of bias tool. Results： A total of nine studies were included in this review. There were five current interventions by CNSs for patients with COPD. These interventions were home nursing support, CNS]s supported discharge, multidisciplinary cooperation programs, nurse-led care programs, and self-care management education. The effectiveness of these five interventions was evaluated individually. There is low- to moderate-quality evidence indicating that home nursing support interventions may have a positive effect on mortality and quality of life. No significant difference in quality of life has been found between the CNS-supported discharge intervention and the usual service. The multidisciplinary cooperation program probably had a positive effect on quality ot life in patients with COPD. Both nurse-led care and self-care management education intervention had a positive effect on mortality of patients with COPD.Conclusions： The findings of this review provide updated evidence on the effectiveness of CNS interventions for patients with COPD. Although nine trials were included and five types of interventions were identified, there is still lack of high-quality evidence. 展开更多
关键词 chronic obstructive pulmonary disease （COPD） clinical nurse specialists （CNSs） effectiveness systematic review advanced practice nurse RNS CNS led
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Co-metabolic and biochar-promoted biodegradation of mixed PAHs by highly efficient microbial consortium QY1 认领 引用 被引量：9
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作者 Min Li Hua Yin +3 位作者 Minghan Zhu Yuanyuan Yu Guining Lu Zhi Dang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第9期65-76,共12页
Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outs... Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outstanding PAHs-degrading capacity has been enriched.The degradation characteristics of single and mixed PAHs treated with QY1 were studied, and the effect of biochar on biodegradation of mixed PAHs and the potential of biochar in PAHs-heavy metal combined pollution bioremediation were also investigated.Results showed that, in single substrate system, QY1 degraded 94.5% of 500 mg/L phenanthrene(PHE) and 17.8% of 10 mg/L pyrene(PYR) after 7 days, while in PHE-PYR mixture system, the biodegradation efficiencies of PHE(500 mg/L) and PYR(10 mg/L) reached 94.0%and 96.2%, respectively, since PHE served as co-metabolic substrate to have significantly improved PYR biodegradation.Notably, with the cooperation of biochar, the biodegradations of PHE and PYR were greatly accelerated.Further, biochar could reduce the adverse impact of heavy metals(Cd2+, Cu2+, Cr2O72-) on PYR biodegradation remarkably.The sequencing analysis revealed that Methylobacterium, Burkholderia and Stenotrophomonas were the dominant genera of QY1 in almost all treatments, indicating that these genera might play key roles in PAHs biodegradation.Overall, this study provided new insights into the efficient bioremediation of PAHs-contaminated site. 展开更多
关键词 Polycyclic aromatic hydrocarbons Microbial consortium Co-metabolism Biochar Heavy metals Microbial community
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Degradation of 2,2′,4,4′-tetrabromodiphenyl ether by Pycnoporus sanguineus in the presence of copper ions 认领 引用 被引量：5
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作者 Meiqian Wang Hua Yin +3 位作者 Hui Peng Mi Feng Guining Lu Zhi Dang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第9期133-143,共11页
The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of ... The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of metabolites, as well as to further elucidate the degradation mechanism of BDE-47. An increase in degradation rate from 18.63% to49.76% in the first four days and its stabilization at(51.26 ± 0.08)% in the following days of BDE-47 incubation were observed. The presence of Cu2+ at 1 and 2 mg/L was found to promote the degradation rate to 56.41% and 60.79%, respectively, whereas higher level of Cu2+(≥ 5 mg/L) inhibited the removal of BDE-47. The similar concentration effects of Cu2+ was also found on contents of fungal protein and amounts of metabolites. Both intracellular and extracellular enzymes played certain roles in BDE-47 transportation with the best degradation rate at 27.90% and 27.67% on the fourth and third day, individually. During the degradation of BDE-47, four types of hydroxylated polybrominated diphenyl ethers(OH-PBDEs), i.e., 6′-OH-BDE-47, 5′-OH-BDE-47, 4′-OH-BDE-17, 2′-OH-BDE-28, and two bromophenols, i.e., 2,4-DBP and 4-BP were detected and considered as degradation products. These metabolites were further removed by P. sanguineus at rates of 22.42%,23.01%, 27.04%, 27.96%, 64.21%, and 40.62%, respectively. 展开更多
关键词 Degradation BDE-47 Copper Pycnoporus sanguineus OH-PBDEs
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Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone 认领 引用 被引量：4
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作者 Xiao-lin Hou Yan Chen +1 位作者 Hua Yin Wei-gang Duan 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第11期1836-1840,共5页
Resistance mechanisms of rho-associated kinase（ROCK） inhibitors are associated with the enhanced expression of cyclooxygenase-2（COX-2）. The therapeutic effects of ROCK on nervous system diseases might be enhanced ... Resistance mechanisms of rho-associated kinase（ROCK） inhibitors are associated with the enhanced expression of cyclooxygenase-2（COX-2）. The therapeutic effects of ROCK on nervous system diseases might be enhanced by COX-2 inhibitors. This study investigated the synergistic effect of the combined use of the ROCK inhibitor fasudil and a COX-2 inhibitor celecoxib on spinal cord injury in a rat model established by transecting the right half of the spinal cord at T11. Rat models were orally administrated with celecoxib（20 mg/kg） and/or intramuscularly with fasudil（10 mg/kg） for 2 weeks. Results demonstrated that the combined use of celecoxib and fasudil significantly decreased COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury, improved the pathomorphology of the injured spinal cord, and promoted the recovery of motor function. Moreover, the effects of the drug combination were better than celecoxib or fasudil alone. This study demonstrated that the combined use of fasudil and celecoxib synergistically enhanced the functional recovery of injured spinal cord in rats. 展开更多
关键词 nerve regeneration Rho kinase fasudil cyclooxygenase-2 celecoxib spinal cord injury NSFC grant neural regeneration
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Tolerance of neurite outgrowth to Rho kinase inhibitors decreased by cyclooxygenase-2 inhibitor 认领 引用 被引量：1
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作者 Weigang Duan Ling Que +3 位作者 Xiaoman Lv Qifeng Li Hua Yin Luyong Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第34期2705-2712,共8页
In this study, PC12 Adh cells and Neuro-2a cells were treated with Rho-associated kinase inhibitors （Y27632 and Fasudil）, a cyclooxygenase-1 selective inhibitor （SC560）, and a cyclooxygenase-2 inhibitor （NS398）.... In this study, PC12 Adh cells and Neuro-2a cells were treated with Rho-associated kinase inhibitors （Y27632 and Fasudil）, a cyclooxygenase-1 selective inhibitor （SC560）, and a cyclooxygenase-2 inhibitor （NS398）. We found that these cells became tolerant to Rho-associated kinase inhibitors, as neurite outgrowth induced by these inhibitors diminished following more than 3 days of exposure in either cell line. The proteins cyclooxygenase-2 and cytosolic prostaglandin E synthetase were upregulated at day 3. NS398 decreased the tolerance to neurite outgrowth induction in both cell lines, whereas SC560 had almost no effect. These findings indicate that cells become tolerant to neurite outgrowth induced by Rho-associated kinase inhibitors, this is at least partly associated with upregulation of proteins involved in the cyclooxygenase-2 pathway, and cyclooxygenases-2 inhibition prevents this tolerance. 展开更多
关键词 Rho-associated kinase inhibitors Y27632 fasudil neurite cyclooxygenase 2 inhibitors drugtolerance
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芳香族香料化合物生物合成研究进展 认领 引用 被引量：13
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作者 庄以彬 吴凤礼 +2 位作者 殷华 王钦宏 刘涛 《生物工程学报》 CAS CSCD 北大核心 2021年第6期1998-2009,共12页
芳香族化合物在香料中占很大的比重,传统生产方式有化学合成和植物提取。化学合成依赖于石油资源,并具有环境不友好、反应条件恶劣等缺点。植物提取方法受限于植物资源,且占用耕地。近年来,随着代谢工程和合成生物学技术的发展,利用可... 芳香族化合物在香料中占很大的比重,传统生产方式有化学合成和植物提取。化学合成依赖于石油资源,并具有环境不友好、反应条件恶劣等缺点。植物提取方法受限于植物资源,且占用耕地。近年来,随着代谢工程和合成生物学技术的发展,利用可再生原料,微生物合成芳香族香料化合物成为一种新的生产方式。文中介绍了大肠杆菌和酵母菌等模式微生物合成芳香族香料的研究进展,包括利用莽草酸途径合成香兰素等,聚酮途径合成覆盆子酮等。综述重点介绍了生物合成途径解析、人工合成途径创建及代谢调控等,为微生物发酵法生产芳香族香料化合物提供参考。 展开更多
关键词 芳香族化合物 香料 生物合成 莽草酸 聚酮
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不同寄主植物对云南松毛虫生长发育、繁殖及生理酶活性的影响 认领 引用 被引量：9
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作者 沈海燕 梁运 +7 位作者 陈正浩 华银 李昌良 张珠河 翁怀锋 黄飚 张飞萍 梁光红 《林业科学研究》 CSCD 北大核心 2022年第5期63-70,共8页
[目的]基于不同寄主植物对云南松毛虫(Dendrolimus houi Lajonquiere)生长发育、繁殖、解毒酶和消化酶活性的影响,解析其对不同寄主植物的生理适应机制,为营造新型混交林开展生态调控提供理论依据。[方法]以柳杉、侧柏、柏木、云南松和... [目的]基于不同寄主植物对云南松毛虫(Dendrolimus houi Lajonquiere)生长发育、繁殖、解毒酶和消化酶活性的影响,解析其对不同寄主植物的生理适应机制,为营造新型混交林开展生态调控提供理论依据。[方法]以柳杉、侧柏、柏木、云南松和马尾松为寄主植物进行室内饲养,分别比较不同寄主植物条件下云南松毛虫幼虫、蛹的发育历期和成虫繁殖力,并测定云南松毛虫5龄幼虫的解毒酶(谷胱甘肽-S-转移酶(GSTs)、细胞色素P450酶(CYP450)、羧酸酯酶(CarE))和消化酶(蛋白酶、淀粉酶(AMS)、脂肪酶(LPS))的活性。[结果]取食柳杉、柏木、侧柏和云南松的云南松毛虫幼虫具完整的生活史,而取食马尾松的幼虫只存活至5龄,不具有完整的生活史。同时,取食柳杉和柏木的云南松毛虫幼虫和蛹发育历期短、雌蛹重且成虫产卵多。取食柳杉和柏木的云南松毛虫5龄幼虫体内谷胱甘肽-S-转移酶和细胞色素P450酶活性显著高于取食云南松、侧柏和马尾松的幼虫(P<0.05)。在3种消化酶中,取食柳杉与柏木的云南松毛虫幼虫体内蛋白酶活性均处于较高水平。[结论]云南松毛虫对柳杉和柏木具较好的适应性,虫体内解毒酶和蛋白酶可能是其对柳杉和柏木有较好适应性的主要原因。 展开更多
关键词 云南松毛虫 寄主植物 发育历期 解毒酶 消化酶
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我国柳杉毛虫研究进展 认领 引用 被引量：6
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作者 华银 卢赐鼎 +5 位作者 是雨霏 何欢 韩小红 林浩宇 张飞萍 梁光红 《世界林业研究》 CSCD 北大核心 2019年第4期62-68,共7页
柳杉毛虫是一种大型鳞翅目类食叶害虫,在我国南方多个省份均有分布,可危害柳杉、云南松、侧柏等多种寄主,其中以柳杉较为严重,重者导致林分大面积枯死。文中在收集查阅近60年来国内外相关文献的基础上,从寄主与分布、生物学特性、生态... 柳杉毛虫是一种大型鳞翅目类食叶害虫,在我国南方多个省份均有分布,可危害柳杉、云南松、侧柏等多种寄主,其中以柳杉较为严重,重者导致林分大面积枯死。文中在收集查阅近60年来国内外相关文献的基础上,从寄主与分布、生物学特性、生态学特性、虫害综合防治和资源利用等方面进行了综述。发现该虫在不同区域能适应不同的寄主,并在夏、冬季节对极端温度具有特殊的适应性;柳杉毛虫性引诱剂的开发和应用可有效杀灭雄虫个体并降低后代种群数量;一些优势天敌具有较好的控害潜能,值得进一步开发利用,可为更好地控制虫害和开展深入研究提供参考。 展开更多
关键词 柳杉 柳杉毛虫 寄主 天敌 引诱剂 虫害防治 中国
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福建柳杉毛虫的七种寄生蝇形态记述和生物学 认领 引用 被引量：5
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作者 梁光红 林浩宇 +6 位作者 卢赐鼎 韩小红 华银 黄信金 谢作贵 张飞萍 张春田 《植物保护》 CAS CSCD 北大核心 2018年第6期177-184,共8页
柳杉毛虫是一种严重为害柳杉的食叶害虫,探明柳杉毛虫的寄生蝇种类,将为该虫优势天敌的筛选提供更多的选择。本研究从野外采集柳杉毛虫幼虫并带回室内饲养,出蛆化蛹,羽化获得不同种类的寄生蝇。对获得的寄生蝇进行分类、鉴定,并描述其... 柳杉毛虫是一种严重为害柳杉的食叶害虫,探明柳杉毛虫的寄生蝇种类,将为该虫优势天敌的筛选提供更多的选择。本研究从野外采集柳杉毛虫幼虫并带回室内饲养,出蛆化蛹,羽化获得不同种类的寄生蝇。对获得的寄生蝇进行分类、鉴定,并描述其系统分类地位、形态特征、地理分布及寄主。调查发现,柳杉毛虫的寄生蝇由多到少依次为蚕饰腹寄蝇Blepharipa zebina(Walker),瘦钩鬃麻蝇Sarcophaga(Sarcorohdendorfia)gracilior(Chen),黑角狭颊寄蝇Carcelia(s.str.)nigrantennata Chao et Liang,松毛虫狭颊寄蝇C.(s.str.)matsukarehae(Shima),星毛虫狭颊寄蝇C.(s.str.)illiberisi Chao et Liang,拟庸赘寄蝇Drino(Palexorista)inconspicuoides(Baranov),羚足鬃麻蝇S.(Sarcorohdendorfia)antilope B&#x00F6;ttcher,共7种,其中蚕饰腹寄蝇、瘦钩鬃麻蝇、黑角狭颊寄蝇分布较广,种群数量较多,寄生率较高,分别为7.44%、7.37%、5.48%,被认为是优势种;且拟庸赘寄蝇为福建新分布记录;柳杉毛虫是黑角狭颊寄蝇、星毛虫狭颊寄蝇、拟庸赘寄蝇的新寄主;还发现2种重寄生蜂寄生于寄生蝇。记述柳杉毛虫的7种寄生蝇形态特征,有助于今后识别其天敌昆虫,研究害虫与天敌的种间关系,评价寄生蝇种群对维护柳杉林分生态系统稳定和防控柳杉毛虫的潜能,具有重要意义。 展开更多
关键词 柳杉毛虫 寄生蝇类 成虫形态 分布 寄主
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福建省柳杉毛虫的发生规律及生物学特性 认领 引用 被引量：9
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作者 周友军 林浩宇 +4 位作者 华银 韩小红 魏招云 张飞萍 梁光红 《亚热带农业研究》 2019年第1期20-26,共7页
对福建省柳杉及柳杉毛虫的分布调查表明,柳杉主要分布于南平、三明、宁德、福州4个地区的多个县(市),龙岩、漳州少数的县(市)呈零星分布,分布海拔介于44～1 203 m之间;柳杉毛虫也主要分布上述4个地区,海拔介于146～1 181 m之间,龙岩、... 对福建省柳杉及柳杉毛虫的分布调查表明,柳杉主要分布于南平、三明、宁德、福州4个地区的多个县(市),龙岩、漳州少数的县(市)呈零星分布,分布海拔介于44～1 203 m之间;柳杉毛虫也主要分布上述4个地区,海拔介于146～1 181 m之间,龙岩、漳州未见分布,具有向低海拔适宜寄主迁移并为害的风险。柳杉毛虫1年1代,高海拔地区以卵越冬,低海拔地区以卵或低龄幼虫越冬。卵期一般9月—翌年3月,较耐寒,受精卵孵化率为62%～76%,未受精卵不能孵化;幼虫期介于3月上旬—8月上旬,低龄幼虫食量小、危害较轻,高龄幼虫食量大、危害尤为严重;蛹期为7月上旬—11月中旬;成虫期8月下旬—11月下旬,羽化后即可交配、产卵,产卵期持续6.7 d,平均产卵242粒;雌虫平均寿命12.8 d,雄虫平均寿命10.3 d;雌雄性比为1∶1.22。 展开更多
关键词 柳杉 柳杉毛虫 发生规律 生物学特性
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星天牛转录组及三大解毒酶家族相关基因系统发育分析 认领 引用 被引量：1
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作者 韩小红 卢赐鼎 +5 位作者 华银 林浩宇 是雨霏 吴松青 张飞萍 梁光红 《林业科学》 EI CAS CSCD 北大核心 2019年第5期104-113,共10页
【目的】研究星天牛转录组信息及体内细胞色素P450单加氧酶(cytochrome P450 monooxygenase,CYP)、羧酸酯酶(carboxylesterase,CarE)和谷胱甘肽S-转移酶(glutathione S-transferase,GST)三大解毒酶系的表达谱情况,通过构建系统进化树,... 【目的】研究星天牛转录组信息及体内细胞色素P450单加氧酶(cytochrome P450 monooxygenase,CYP)、羧酸酯酶(carboxylesterase,CarE)和谷胱甘肽S-转移酶(glutathione S-transferase,GST)三大解毒酶系的表达谱情况,通过构建系统进化树,探析其这3种酶系基因家族的类别及其系统演化关系,为星天牛对多寄主种类的适应性与杀虫剂的抗药性机制研究提供依据。【方法】采用新一代高通量测序技术Illumina HiSeq TM 2500 对星天牛进行转录组测序与数据分析,通过数据筛选并进一步与鞘翅目近缘物种的解毒酶同源蛋白进行系统发育分析。【结果】经测序、序列拼接得到55 260条unigenes,将其与公共数据库进行同源比对,注释了32 247条unigenes,在Swiss-Prot数据库注释的unigenes的数量最多(99.11%);注释到Nr数据库时与赤拟谷盗的unigenes同源性最高(60.25%);在GO数据库中,共有8 083个unigenes被成功注释,根据其功能大致可分为3 类47 亚类;在KEGG数据库中,4 600 条unigenes与162个预测路径可以匹配。通过基因注释发现248条解毒酶系基因在星天牛体内表达,包括139条CYP基因、72条CarE基因、37条GST基因。系统发育分析发现,星天牛的大部分CYP基因都至少与一种鞘翅目近缘物种的CYP基因聚类在一起,P450基因中的CYP6家族数量与其他近缘物种(鞘翅目)类似,包含的基因数量最多;CarE解毒酶蛋白基因主要为β-酯酶、神经趋化蛋白、外源性代谢酶、未知等4种类型,分别可能参与星天牛的一些激素以及信息素的加工、神经和发育过程、消化与解毒等生理过程;星天牛的GST基因聚类主要包含Microsomal GST、Sigma GST、Omega GST、Delta GST、Theta GST等亚家族,具有保护生物大分子免受氧化损伤、催化活力等功能。【结论】本研究获得星天牛的转录组信息,初步探明星天牛体内三大解毒酶系的表达谱及分化情况,可为星天牛对多寄主种类的适应性与杀虫剂抗药性的产生及遗传机制研究提供基础数据和参考。 展开更多
关键词 星天牛 转录组 高通量测序 系统发育 解毒酶蛋白基因
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X波段测波雷达海流信息反演的影响因素分析 认领 引用 被引量：1
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作者 王立 洪丽娟 +3 位作者 刘辛宇 成云飞 华寅 吴雄斌 《武汉大学学报（信息科学版）》 EI CAS CSCD 北大核心 2017年第12期1804-1810,共7页
X波段测波雷达海流信息的提取决定着有效浪高结果的准确度。因此,对可能影响X波段测波雷达海流信息提取的各种环境因素以及雷达工作模式等进行了海浪回波成像仿真,然后采用目前测波雷达通用的算法对仿真回波图像进行了海流信息反演。主... X波段测波雷达海流信息的提取决定着有效浪高结果的准确度。因此,对可能影响X波段测波雷达海流信息提取的各种环境因素以及雷达工作模式等进行了海浪回波成像仿真,然后采用目前测波雷达通用的算法对仿真回波图像进行了海流信息反演。主要研究了海表面风速、雷达天线架设距离海平面高度、天线转速、海流流速、海流流向与海浪方向夹角、所选取的图像帧数以及每帧图像大小对海流信息反演的影响。对比分析设定值与反演结果,可知海表面风速在6~14 m/s之间,天线高度大于20 m并且转速为50~70r/min,流速小于200cm/s并且主波浪向与流向夹角不接近90°,图像帧数为128帧并且每帧图像数据点数为128×128时,X波段测波雷达能获得最佳海流信息反演结果。 展开更多
关键词 X波段雷达 海洋观测 海流信息反演 影响因素 海面成像仿真
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基于双非线性预测滤波法的锂离子电池SOH估计 认领 引用 被引量：7
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作者 华寅 许敏 《电源技术》 CAS CSCD 北大核心 2018年第9期1321-1324,共4页
动力电池的健康状态(SOH)估计是电动汽车电池管理系统的关键技术之一。提出了一种基于双非线性预测滤波法的锂离子电池SOH估计方法。基于Thevenin等效电路模型来表达电池的性能,基于双非线性预测滤波法对电池的容量和内阻进行估计从而实... 动力电池的健康状态(SOH)估计是电动汽车电池管理系统的关键技术之一。提出了一种基于双非线性预测滤波法的锂离子电池SOH估计方法。基于Thevenin等效电路模型来表达电池的性能,基于双非线性预测滤波法对电池的容量和内阻进行估计从而实现SOH的在线估计,基于磷酸铁锂电池的循环寿命测试对提出的方法进行验证,结果表明,基于双非线性预测滤波法的SOH估计方法能够在电池的整个生命周期内实现SOH的精确预测。 展开更多
关键词 电动汽车 锂离子电池 SOH估计 双非线性预测滤波
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Intravenous preemptive analgesia modifies the distribution of lymphocyte subsets after radical mastectomy 认领 引用
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作者 Feifei Lou Zhiming Tan +4 位作者 Hua Yin Changhong Miao Yajun Xu Jiawei Chen Wei Chen 《The Chinese-German Journal of Clinical Oncology》 2009年第10期572-577,共6页
Objective: In this study, we evaluated the effect of preemptive analgesia of flurbiprofen axetil (FA) and tramadol on immune response in patients undergoing radical mastectomy. Methods: In this prospective randomized,... Objective: In this study, we evaluated the effect of preemptive analgesia of flurbiprofen axetil (FA) and tramadol on immune response in patients undergoing radical mastectomy. Methods: In this prospective randomized, double-blind, placebo-controlled study, 80 patients were randomly assigned to one of four groups (n = 20). The FA group (group A) patients received FA before tracheal intubation and at the end of surgery. The tramadol group (group B) patients received tramadol before tracheal intubation and at the end of surgery. The control group (group C) patients received saline before tracheal intubation and at the end of surgery. The combination group (group D) patients received FA and tramadol before tracheal intubation and at the end of surgery. Cluster of differentiation and lymphocytes were measured. Results: The CD3, CD4, CD8 and lymphocytes decreased postoperatively of all groups except of group A and D at 0.5 h postoperatively (P < 0.05). The CD3, CD4, CD8 and lymphocytes of group D were higher than those of group C at 0.5 h and 4 h postoperatively (P < 0.05). Conclusion: Preemptive analgesia using flurbiprofen axetil (FA) and tramadol may protect the immune system. The immune protective effect of FA may be better than that of tramadol. The combination of FA and tramadol may be the most effective among all the strategies. 展开更多
关键词 preemptive analgesia pain lymphocyte flurbiprofen axetil tramadol
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一例以多发性骨破坏为显著特征的老年戈谢病的诊疗和基因检测分析 认领 引用
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作者 秦姝超 尹华 +3 位作者 王蓉 朱飞鹏 李建勇 卢瑞南 《遗传》 CAS CSCD 北大核心 2023年第3期261-269,共9页
戈谢病(Gaucher’s disease)是一种罕见的常染色体隐性遗传病,由于葡萄糖脑苷脂酶(glucocerebrosidase,GBA)基因突变导致溶酶体中GBA活性降低或缺乏,造成其底物葡萄糖脑苷脂在溶酶体中贮积,产生肝、脾、肾、骨、造血系统甚至神经系统受... 戈谢病(Gaucher’s disease)是一种罕见的常染色体隐性遗传病,由于葡萄糖脑苷脂酶(glucocerebrosidase,GBA)基因突变导致溶酶体中GBA活性降低或缺乏,造成其底物葡萄糖脑苷脂在溶酶体中贮积,产生肝、脾、肾、骨、造血系统甚至神经系统受累的临床表现。本文报道1例以多发性骨破坏为显著特征的老年患者,伴有幼年脾切除及“骨髓炎”病史,呈现肝脏显著增大、贫血、血小板减少及骨量减少等症状。临床检测显示,患者外周血GBA活性降低、葡糖鞘氨醇水平以及壳三糖酶活性显著升高;基因检测结果表明,患者GBA基因发生纯合错义突变NM_001005741.2 c.770A>G(p.Asp257Gly)。经过6个月的酶替代治疗,患者血小板恢复正常、贫血改善、肝脏体积有所缩小。进一步检测发现患者母亲、长兄、次兄均存在该位点的杂合突变,符合孟德尔遗传规律。虽然患者Asp257Gly变异在已知的GBA基因变异库中未被报道,但无论是临床表现还是酶学及生物标记物特征,以及酶替代治疗的效果,均支持戈谢病的诊断,推断患者Asp257Gly纯合变异为临床致病性变异。本病例发现的新突变位点丰富了GBA基因的遗传变异数据库,同时本病例的诊治过程也为该类患者的早期识别并诊断以及尽早治疗提供了借鉴与参考。 展开更多
关键词 戈谢病 多发骨破坏 老年 葡萄糖脑苷脂酶基因
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