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Inhibition performance and mechanisms of methane hydrate inhibitors in oil and gas pipelines 认领 引用
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作者 Jie Wang Yong Cheng +3 位作者 Yuan Li Pan Ma Hualei Xu Houshun Jiang 《Natural Gas Industry B》 2026年第2期239-255,共17页
During winter natural gas transportation,hydrate formation under low-temperature and high-pressure conditions frequently results in pipeline blockage and severe low assurance challenges.Although conventional thermodyn... During winter natural gas transportation,hydrate formation under low-temperature and high-pressure conditions frequently results in pipeline blockage and severe low assurance challenges.Although conventional thermodynamic hydrate inhibitors(THIs)are effective in shifting hydrate phase equilibrium,the application is constrained by high volumetric injection requirements and the associated operational costs,thereby driving research interest toward low-dosage hydrate inhibitors(LDHIs).This study integrates high-pressure pipeline flow simulations with molecular dynamics simulations to systematically evaluate the inhibition performance and elucidate the molecular-scale mechanisms of representative inhibitor classes in methane hydrates.Pipeline simulation results indicate that,at low additive concentrations:(1)the inhibition effectiveness of cations follows the order Al3+>Fe2+>Ca2+>Na+,suggesting a strong dependence on ionic charge density;(2)at identical mass fraction,methanol exhibits greater thermodynamic inhibition performance than ethylene glycol.Notably,5.0 wt% ethylene glycol accelerates hydrate formation kinetics,exhibiting an anomalous promotion effect.For kinetic inhibitors and their blends,the following observations were obtained:(3)PVP K30 exhibited optimal inhibition performance at 1.0 wt%,significantly extending the hydrate induction time;moreover,the combination of 1.0 wt%PVP K30 with 5.0 wt%methanol completely suppressed hydrate formation under the tested conditions while substantially reducing the required alcohol dosage;(4)molecular-scale analysis indicates that methanol and ethylene glycol primarily act by shifting the hydrate phase equilibrium and perturbing the hydrogen-bond network of water.In contrast,PVP K30 inhibits hydrate formation by disrupting hydrogen-bond structures and decreasing methane-water association through steric hindrance and interfacial adsorption.The blended system exhibits a clear synergistic effect between thermodynamic and kinetic inhibition,combining a phase equilibrium shift with delayed hydrate formation kinetics.This THI-focused investigation systematically clarifies the inhibition of mechanisms of representative additives and provides a scientific basis for selecting costeffective LDHIs strategies for hydrate control in oil and gas pipelines,with direct relevance to mitigating hydrate blockage in field operations. 展开更多
关键词 Methane hydrates Pipeline transport Hydrate inhibitors Molecular dynamics simulation Synergistic inhibition effect
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4-Aminoazobenzene:A novel negative ion matrix for enhanced MALDI tissue imaging of metabolites 认领 引用 被引量：2
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作者 Ran Wu Dongxu Jiang +14 位作者 Hao Hu Chenyu Yang Liang Qin Lulu Chen Zehui Hu Hualei Xu Jinrong Li Haiqiang Liu Hua Guo Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Qiang Wang Xiaodong Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第11期273-277,共5页
Endogenous metabolites play key functions in many important physiological and biochemical processes.The comprehensive in situ detection and direct imaging of metabolites in bio-tissues by matrix-assisted laser desorpt... Endogenous metabolites play key functions in many important physiological and biochemical processes.The comprehensive in situ detection and direct imaging of metabolites in bio-tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)is very important for understanding complex and diverse biological processes and has become an essential aspect of spatial omics.In this work,4-aminoazobenzene(AAB)was successfully screened and optimized as a new negative ion(-)MALDI matrix to enhance the in situ detection and imaging of metabolites in tissues using MALDIMSI.Obviously,AAB exhibited superior properties in terms of ultraviolet absorption,background ion interference,matrix morphology,and metabolite ionization efficiency.AAB was used for in situ detection and imaging of metabolites in rat brain and germinating Chinese yew seed tissue sections,where 264and 339 metabolite ion signals were successfully detected and imaged using(-)MALDI-MS,respectively.In addition,high-resolution imaging of mouse eyeball section using MALDI-tims TOF MSI with spatial resolution of up to 10μm was successfully carried out,showing that AAB is an efficient(-)MALDI matrix for capturing high-resolution images of metabolites in biological tissue sections. 展开更多
关键词 MALDI-MSI 4-Aminoazobenzene Metabolites In situ detection Tissue imaging
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4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI 认领 引用
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作者 Hualei Xu Manman Han +12 位作者 Haiqiang Liu Liang Qin Lulu Chen Hao Hu Ran Wu Chenyu Yang Hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Xiaodong Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第6期486-490,共5页
Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological processes.The direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ion... Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological processes.The direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive understanding of their essential functions.Here,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by MALDI-MS.Our results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background peaks.The use of 4-NC led to the successful detection of 232,218,and193 LMW compounds from the three abovementioned tissue sections,respectively.Also,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds. 展开更多
关键词 MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging
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Enhancement of lipid MALDI tissue imaging using 1,4-dihydroxy-2-naphthoic acid as a novel matrix 认领 引用
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作者 Rui Liu Li Long +10 位作者 Xiaoyi Yan Hua Guo Ran Wu Hao Hu Hualei Xu Qichen Hao Liang Qin Lulu Chen Huaqing Zhang Junwei Wang Xiaodong Wang 《Science China Chemistry》 SCIE EI CAS CSCD 2025年第10期4781-4784,共4页
Lipids are the basic components of cells that are involved in physiological processes such as energy transfer,signal transduction,cell growth,and apoptosis,thus playing important biological functions in organisms[1].M... Lipids are the basic components of cells that are involved in physiological processes such as energy transfer,signal transduction,cell growth,and apoptosis,thus playing important biological functions in organisms[1].Moreover,lipids are biomarkers for many diseases,including coronary heart disease,hepatitis C,and diabetes.A substantial number of studies have shown that obtaining accurate and comprehensive data on the spatial distribution of lipids is essential for investigating pathogenesis and identifying diagnostic biomarkers[2]. 展开更多
关键词 MALDI Enhancement of lipid MALDI tissue imaging using 1 4-dihydroxy-2-naphthoic acid as a novel matrix
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化学衍生化技术及其在质谱成像中的应用进展 认领 引用 被引量：7
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作者 李金融 秦亮 +10 位作者 蒋东旭 刘海强 许华磊 杨晨钰 陈涤凡 吴冉 胡浩 李艳艳 周宜君 冯金朝 王晓东 《中国科学：化学》 CAS CSCD 北大核心 2022年第7期1041-1073,共33页
近年来,随着质谱成像(mass spectrometry imaging,MSI)技术的不断发展与完善,众多基于MSI的分析策略已被广泛应用于生物内/外源分子原位、定性、定量可视化研究,其中又以基质辅助激光解析电离质谱成像(matrix assisted laser desorption... 近年来,随着质谱成像(mass spectrometry imaging,MSI)技术的不断发展与完善,众多基于MSI的分析策略已被广泛应用于生物内/外源分子原位、定性、定量可视化研究,其中又以基质辅助激光解析电离质谱成像(matrix assisted laser desorption/ionization MSI,MALDI-MSI)和DESI-MSI(desorption electrospray ionization MSI)最为常用.相较于传统分子影像方法,MSI技术具有高灵敏、高通量、无需标记等优点,但仍存在一些不足,尤其在低极性、难电离中性分子原位分析中短板明显.针对这一难题,化学衍生化技术的发展与应用已成为极其重要的手段之一.本文系统性地综述了多种化学衍生化技术,如酯化衍生化、酰化衍生化、加成衍生化、取代衍生化、氧化衍生化及其他衍生化技术,在MALDI-MSI及DESI-MSI分子表征中的应用进展.可以预见,化学衍生化技术的不断发展与完善将进一步拓展MSI技术在原位代谢组学、原位脂质组学、原位蛋白质组学、原位糖组学等领域的应用范围. 展开更多
关键词 化学衍生化 质谱成像 基质辅助激光解吸电离 解析电喷雾电离 原位表征
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