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- 西藏各地市健康人群H.pylori菌感染状况分析 认领 引用 被引量：5
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- 作者 陈茉 刘超 +4 位作者 李晓萍 宦徽 胡仁伟 吴浩 邓凯 《世界华人消化杂志》 CAS 2018年第31期1825-1831,共7页
- 目的了解目前西藏地区人群幽门螺旋杆菌(Helicobacter pylori, H. pylori)的感染状况,为西藏地区幽门螺杆菌感染的防治提供临床数据.方法回顾2017年于西藏自治区人民政府驻成都办事处医院就诊且同时完成13C-尿素呼气试验的西藏地区体检... 目的了解目前西藏地区人群幽门螺旋杆菌(Helicobacter pylori, H. pylori)的感染状况,为西藏地区幽门螺杆菌感染的防治提供临床数据.方法回顾2017年于西藏自治区人民政府驻成都办事处医院就诊且同时完成13C-尿素呼气试验的西藏地区体检者,收集临床资料、常居留地及H. pylori检测结果等.结果共纳入931例病例, H. pylori总体阳性率为480/931(51.6%,95%C I:48.3%-54.8%),其中藏族586例, H.pylori阳性率为331/586(56.5%,95%CI:52.5%-60.5%);汉族345例, H.pylori阳性率为149/345(43.2%,95%CI:37.9%-48.4%).藏汉族之间H.pylori阳性率存在显著差异(P <0.001).西藏地区各地市的H. pylori阳性率分别为:拉萨市99/219(45.2%,95%C I:38.6%-51.8%),昌都市213/372(57.3%,95%C I:52.2%-62.3%),林芝市56/110(50.9%,95%CI:41.4%-60.4%),山南市25/63(39.7%,95%CI:27.3%-52.1%),日喀则市21/51(41.2%,95%C I:27.2%-55.2%),那曲地区17/40(42.5%,95%C I:26.5%-58.5%),阿里地区49/76(64.5%,95%C I:53.5%-75.5%),各地市之间的H.pylori阳性率存在差异(P=0.002).结论西藏地区H. pylori现患率已下降趋于全国水平,藏汉族之间现患率存在差异,各地市H. pylori现患率亦存在差异. 展开更多
- 关键词 幽门螺旋杆菌感染 现患率 13C-尿素呼气试验 西藏 回顾性研究
- 西藏、四川藏汉族健康人群Helicobacter pylori感染情况比较 认领 引用 被引量：2
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- 作者 陈茉 刘超 +3 位作者 宦徽 胡仁伟 吴浩 邓凯 《世界华人消化杂志》 CAS 2018年第23期1402-1407,共6页
- 目的比较分析西藏和四川地区藏幽门螺杆菌(Helicobacter pylori,H.pylori)感染的情况.方法检索西藏成办分院及华西医院接受14C呼气试验检查的体检者,筛选来自西藏和四川地区的藏汉族体检资料,并收集临床资料、常居留地、H.pylori检测结... 目的比较分析西藏和四川地区藏幽门螺杆菌(Helicobacter pylori,H.pylori)感染的情况.方法检索西藏成办分院及华西医院接受14C呼气试验检查的体检者,筛选来自西藏和四川地区的藏汉族体检资料,并收集临床资料、常居留地、H.pylori检测结果等.结果西藏和四川地区分别纳入藏汉族体检者547/297和308/1011例,其总体H.pylori阳性率西藏明显高于四川(50.8%/39.3%,P<0.001).西藏和四川地区的藏族健康人群H.pylori阳性率均高于汉族(56.9%/39.7%,P<0.001;52.3%/35.4%,P<0.001).藏族和汉族健康人群H.pylori阳性率在西藏与四川地区之间无差异(P=0.196和P=0.192).高龄组的H.pylori阳性率在汉族健康人群中出现升高,而在藏族健康人群中出现降低(年龄<45 vs年龄≥45:32.3%/40.5%,P=0.002;61.5%/50.0%,P=0.001).结论西藏与四川地区藏汉族健康人群的H.pylori感染情况相似,均为藏族高于汉族.汉族健康人群H.pylori感染与年龄正相关,而藏族健康人群却相反. 展开更多
- 关键词 幽门螺杆菌感染 藏族 四川 藏区 年龄
- 熄风止动汤治疗儿童肝亢风动型抽动障碍的临床效果 认领 引用 被引量：5
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- 作者 郭延昭 惠欢 +4 位作者 李芳菲 姚楠 李翻 王梅 范家应 《临床医学研究与实践》 2022年第20期23-26,31,共4页
- 目的观察熄风止动汤治疗儿童肝亢风动型抽动障碍的临床有效性、安全性及复发情况。方法按照随机数字表原则将120例肝亢风动型抽动障碍患儿分为对照组和观察组,各60例。对照组采用硫必利进行治疗,观察组采用熄风止动汤进行治疗。比较两... 目的观察熄风止动汤治疗儿童肝亢风动型抽动障碍的临床有效性、安全性及复发情况。方法按照随机数字表原则将120例肝亢风动型抽动障碍患儿分为对照组和观察组,各60例。对照组采用硫必利进行治疗,观察组采用熄风止动汤进行治疗。比较两组的中医证候总积分、耶鲁综合抽动严重程度量表(YGTSS)评分、临床疗效及随访3个月复发情况;分析两组患儿的脑电图检查结果及安全性指标。结果治疗后,两组的中医证候总积分均低于治疗前,且观察组低于对照组(P0.05)。结论熄风止动汤治疗儿童肝亢风动型抽动障碍的效果显著,可明显改善临床体征和症状,复发率低,且安全性高。 展开更多
- 关键词 抽动障碍 肝亢风动型 儿童 熄风止动汤
- 抗痫煎剂添加治疗儿童难治性癫痫的临床效果 认领 引用 被引量：1
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- 作者 郭延昭 惠欢 +4 位作者 范家应 李芳菲 姚楠 李翻 王梅 《临床医学研究与实践》 2021年第17期142-144,共3页
- 目的观察抗痫煎剂添加治疗儿童难治性癫痫的临床效果。方法采用随机数字表法将60例儿童难治性癫痫患儿分为对照组和治疗组,各30例。对照组根据患儿病情规范使用2~3种抗癫痫药物联合治疗。治疗组在对照组基础上根据病情添加抗痫煎剂治疗... 目的观察抗痫煎剂添加治疗儿童难治性癫痫的临床效果。方法采用随机数字表法将60例儿童难治性癫痫患儿分为对照组和治疗组,各30例。对照组根据患儿病情规范使用2~3种抗癫痫药物联合治疗。治疗组在对照组基础上根据病情添加抗痫煎剂治疗。比较两组的治疗效果。结果治疗后,两组的癫痫发作频次均较治疗前显著减少,且治疗组少于对照组(P<0.05)。治疗后,治疗组的癫痫发作持续时间优于对照组,差异具有统计学意义(P<0.05)。结论抗痫煎剂添加治疗儿童难治性癫痫的效果显著,可降低癫痫发作频率,缩短癫痫发作持续时间,改善脑电图,且安全性高。 展开更多
- 关键词 儿童 难治性癫痫 抗痫煎剂 脑电图
- Deep Learning-Based Prediction of High-Risk Gastroesophageal Varices Using Two-Dimensional Shear Wave Elastography 认领 引用
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- 作者 Lan Wang Ruiling He +48 位作者 Lili Zhao Jia Wang Zhengzi Geng Tao Ren Guo Zhang Peng Zhang Kaiqiang Tang Chaofei Gao Fei Chen Liting Zhang Yonghe Zhou Xin Li Fanbin He Hui Huan Wenjuan Wang Yunxiao Liang Juan Tang Fang Ai Tingyu Wang Liyun Zheng Zhongwei Zhao Jiansong Ji Wei Liu Jiaojiao Xu Bo Liu Xuemei Wang Yao Zhang Qiong Yan Muhan Lv Xiaomei Chen Shuhua Zhang Yihua Wang Yang Liu Li Yin Yanni Liu Yanqing Huang Yunfang Liu Kun Wang Meiqin Su Li Bian Ping An Xin Zhang Shaoting Zhang Jinhua Shao Xiangman Zhang Wei Rao Linxue Qian Shao Li Xiaolong Qi 《Portal Hypertension & Cirrhosis》 2025年第3期141-156,共16页
- Aims:Bleeding from gastroesophageal varices(GEV)is a medical emergency associated with high mortality.We aim to construct an artificial intelligence-based model of two-dimensional shear wave elastography(2D-SWE)of the... Aims:Bleeding from gastroesophageal varices(GEV)is a medical emergency associated with high mortality.We aim to construct an artificial intelligence-based model of two-dimensional shear wave elastography(2D-SWE)of the liver and spleen to precisely assess the risk of GEV and high-risk GEV(HRV).Methods:This was a multicenter,prospective study conducted from October 2020 to September 2022 across 12 hospitals in China.Patients with compensated advanced chronic liver disease(cACLD)were enrolled,with informed consent obtained.A total of 1136 liver stiffness measurement(LSM)images and 1042 spleen stiffness measurement(SSM)images generated by 2D SWE.Weleveraged deep learning methods to uncover associations between image features and patient risk;in this manner,we constructed models to predict GEV and HRV.Results:A multimodality deep learning risk prediction(DLRP)model was constructed to assess GEV and HRV based on LSM and SSM images and clinical information.Validation analysis revealed that the area under the curve(AUC)values of DLRP were 0.91 for GEV(95%confidence interval[CI],0.90-0.93,p<0.05)and 0.88 for HRV(95%CI,0.86-0.89,p<0.01),which were significantly and robustly better than those of canonical risk indicators,including the values of LSM(0.63 and 0.68 for GEV and HRV)andSSM(0.75for both GEV andHRV).Moreover,the DLRP model outperformed the model using individual parameters.In HRV prediction,the 2D-SWE SSM images(0.75)were more informative than LSM(0.68,p<0.01).Conclusion:Our DLRP model shows excellent performance in predicting GEV and HRV,outperforming the canonical risk indicators LSM and SSM.Additionally,the 2D-SWE SSM images provided more information and thus better accuracy in HRV prediction than the LSM images. 展开更多
- 关键词 compensated advanced chronic liver disease deep learning gastroesophageal varices high-risk gastroesophageal varices two-dimensional shear wave elastography images
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- Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study 认领 引用 被引量：5
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- 作者 Jun‐Hui Sun He Zhao +63 位作者 Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi 《Portal Hypertension & Cirrhosis》 2022年第1期7-14,共8页
- Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with ... Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. 展开更多
- 关键词 design hypertension multicenter study portal pressure prospective study questionnaire wedge
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- One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China 认领 引用
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- 作者 Jitao Wang Ting Cui +87 位作者 Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi 《Portal Hypertension & Cirrhosis》 2024年第2期116-123,共8页
- Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to in... Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future. 展开更多
- 关键词 application status hepatic vein pressure gradient questionnaire survey
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- 题名西藏各地市健康人群H.pylori菌感染状况分析 认领 引用 被引量：5
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- 作者 陈茉 刘超 李晓萍 宦徽 胡仁伟 吴浩 邓凯
- 机构 四川大学华西医院西藏成办分院消化内科 四川大学华西医院消化内科
- 出处 《世界华人消化杂志》 CAS 2018年第31期1825-1831,共7页
- 基金 国家自然科学基金青年项目 No.81600511 +1 种基金 四川大学青年启动基金 No.2017SCU11073~~
- 摘要 目的了解目前西藏地区人群幽门螺旋杆菌(Helicobacter pylori, H. pylori)的感染状况,为西藏地区幽门螺杆菌感染的防治提供临床数据.方法回顾2017年于西藏自治区人民政府驻成都办事处医院就诊且同时完成13C-尿素呼气试验的西藏地区体检者,收集临床资料、常居留地及H. pylori检测结果等.结果共纳入931例病例, H. pylori总体阳性率为480/931(51.6%,95%C I:48.3%-54.8%),其中藏族586例, H.pylori阳性率为331/586(56.5%,95%CI:52.5%-60.5%);汉族345例, H.pylori阳性率为149/345(43.2%,95%CI:37.9%-48.4%).藏汉族之间H.pylori阳性率存在显著差异(P <0.001).西藏地区各地市的H. pylori阳性率分别为:拉萨市99/219(45.2%,95%C I:38.6%-51.8%),昌都市213/372(57.3%,95%C I:52.2%-62.3%),林芝市56/110(50.9%,95%CI:41.4%-60.4%),山南市25/63(39.7%,95%CI:27.3%-52.1%),日喀则市21/51(41.2%,95%C I:27.2%-55.2%),那曲地区17/40(42.5%,95%C I:26.5%-58.5%),阿里地区49/76(64.5%,95%C I:53.5%-75.5%),各地市之间的H.pylori阳性率存在差异(P=0.002).结论西藏地区H. pylori现患率已下降趋于全国水平,藏汉族之间现患率存在差异,各地市H. pylori现患率亦存在差异.
- 关键词 幽门螺旋杆菌感染 现患率 13C-尿素呼气试验 西藏 回顾性研究
- Keywords Helicobacter pylori infection Prevalence rate 13C-urea breath test Tibet Retrospective study
- 分类号 R573 [医药卫生—消化系统]
- 题名西藏、四川藏汉族健康人群Helicobacter pylori感染情况比较 认领 引用 被引量：2
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- 作者 陈茉 刘超 宦徽 胡仁伟 吴浩 邓凯
- 机构 四川大学华西医院西藏成办分院消化内科 四川大学华西医院消化内科
- 出处 《世界华人消化杂志》 CAS 2018年第23期1402-1407,共6页
- 基金 国家自然科学基金青年项目 No.81600511 +1 种基金 四川大学青年启动基金 No.2017SCU11073~~
- 摘要 目的比较分析西藏和四川地区藏幽门螺杆菌(Helicobacter pylori,H.pylori)感染的情况.方法检索西藏成办分院及华西医院接受14C呼气试验检查的体检者,筛选来自西藏和四川地区的藏汉族体检资料,并收集临床资料、常居留地、H.pylori检测结果等.结果西藏和四川地区分别纳入藏汉族体检者547/297和308/1011例,其总体H.pylori阳性率西藏明显高于四川(50.8%/39.3%,P<0.001).西藏和四川地区的藏族健康人群H.pylori阳性率均高于汉族(56.9%/39.7%,P<0.001;52.3%/35.4%,P<0.001).藏族和汉族健康人群H.pylori阳性率在西藏与四川地区之间无差异(P=0.196和P=0.192).高龄组的H.pylori阳性率在汉族健康人群中出现升高,而在藏族健康人群中出现降低(年龄<45 vs年龄≥45:32.3%/40.5%,P=0.002;61.5%/50.0%,P=0.001).结论西藏与四川地区藏汉族健康人群的H.pylori感染情况相似,均为藏族高于汉族.汉族健康人群H.pylori感染与年龄正相关,而藏族健康人群却相反.
- 关键词 幽门螺杆菌感染 藏族 四川 藏区 年龄
- Keywords Helicobacter pylon infection Tibetan Sichuan Tibet Age
- 分类号 R573 [医药卫生—消化系统]
- 题名熄风止动汤治疗儿童肝亢风动型抽动障碍的临床效果 认领 引用 被引量：5
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- 作者 郭延昭 惠欢 李芳菲 姚楠 李翻 王梅 范家应
- 机构 西安中医脑病医院脑病八科
- 出处 《临床医学研究与实践》 2022年第20期23-26,31,共4页
- 基金 国家中医药管理局科研项目(No.2019XZZX-EK001)。
- 摘要 目的观察熄风止动汤治疗儿童肝亢风动型抽动障碍的临床有效性、安全性及复发情况。方法按照随机数字表原则将120例肝亢风动型抽动障碍患儿分为对照组和观察组,各60例。对照组采用硫必利进行治疗,观察组采用熄风止动汤进行治疗。比较两组的中医证候总积分、耶鲁综合抽动严重程度量表(YGTSS)评分、临床疗效及随访3个月复发情况;分析两组患儿的脑电图检查结果及安全性指标。结果治疗后,两组的中医证候总积分均低于治疗前,且观察组低于对照组(P0.05)。结论熄风止动汤治疗儿童肝亢风动型抽动障碍的效果显著,可明显改善临床体征和症状,复发率低,且安全性高。
- 关键词 抽动障碍 肝亢风动型 儿童 熄风止动汤
- Keywords tic disorder hepatic hyperactivity and wind type children Xifeng Zhidong decoction
- 分类号 R277.7 [医药卫生—中医学]
- 题名抗痫煎剂添加治疗儿童难治性癫痫的临床效果 认领 引用 被引量：1
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- 作者 郭延昭 惠欢 范家应 李芳菲 姚楠 李翻 王梅
- 机构 西安中医脑病医院脑病八科
- 出处 《临床医学研究与实践》 2021年第17期142-144,共3页
- 基金 陕西省中医药管理局中医药科研项目(No.LCPT097)。
- 摘要 目的观察抗痫煎剂添加治疗儿童难治性癫痫的临床效果。方法采用随机数字表法将60例儿童难治性癫痫患儿分为对照组和治疗组,各30例。对照组根据患儿病情规范使用2~3种抗癫痫药物联合治疗。治疗组在对照组基础上根据病情添加抗痫煎剂治疗。比较两组的治疗效果。结果治疗后,两组的癫痫发作频次均较治疗前显著减少,且治疗组少于对照组(P<0.05)。治疗后,治疗组的癫痫发作持续时间优于对照组,差异具有统计学意义(P<0.05)。结论抗痫煎剂添加治疗儿童难治性癫痫的效果显著,可降低癫痫发作频率,缩短癫痫发作持续时间,改善脑电图,且安全性高。
- 关键词 儿童 难治性癫痫 抗痫煎剂 脑电图
- Keywords children intractable epilepsy Kangxian decoction electroencephalogram
- 分类号 R742.1 [医药卫生—神经病学与精神病学]
- 题名Deep Learning-Based Prediction of High-Risk Gastroesophageal Varices Using Two-Dimensional Shear Wave Elastography 认领 引用
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- 作者 Lan Wang Ruiling He Lili Zhao Jia Wang Zhengzi Geng Tao Ren Guo Zhang Peng Zhang Kaiqiang Tang Chaofei Gao Fei Chen Liting Zhang Yonghe Zhou Xin Li Fanbin He Hui Huan Wenjuan Wang Yunxiao Liang Juan Tang Fang Ai Tingyu Wang Liyun Zheng Zhongwei Zhao Jiansong Ji Wei Liu Jiaojiao Xu Bo Liu Xuemei Wang Yao Zhang Qiong Yan Muhan Lv Xiaomei Chen Shuhua Zhang Yihua Wang Yang Liu Li Yin Yanni Liu Yanqing Huang Yunfang Liu Kun Wang Meiqin Su Li Bian Ping An Xin Zhang Shaoting Zhang Jinhua Shao Xiangman Zhang Wei Rao Linxue Qian Shao Li Xiaolong Qi
- 机构 Institute for TCM-X,MOE Key Laboratory of Bioinformatics,Bioinformatics Division,Department of Automation,Tsinghua University Department of Ultrasound,Donggang Branch the First Hospital of Lanzhou University,Lanzhou The First Clinical Medical College of Lanzhou University,Lanzhou Department of Gastroenterology and Hepatology,Tianjin Second People's Hospital Department of Ultrasound,Beijing Friendship Hospital,Capital Medical University Department of Ultrasound,The People's Hospital of Linxia Department of Gastroenterology,Hospital of Chengdu Office of People's Government of Xizang Autonomous Region Department of Gastroenterology,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Department of Control and Systems Engineering,Nanjing University Department of Ultrasound,The First Hospital of Lanzhou University,Lanzhou Department of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou Department of Ultrasonography,Tianjin Second People's Hospital Department of Infectious Disease,Zigong First People's Hospital Department of Ultrasound,Zigong First People's Hospital Department of Gastroscopy,Zigong First People's Hospital Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,Department of Radiology,Fifth Affiliated Hospital of Wenzhou Medical University,Li Shui Ultrasound Diagnosis Center,Shaanxi Provincial People's Hospital,Shaanxi Department of Ultrasound,Ditan Hospital,Capital Medical University Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University Department of Ultrasound,The Affiliated Hospital of Southwest Medical University Department of Ultrasound,North China University of Science and Technology Affiliated Hospital,Tangshan Department of Ultrasound,Jincheng People's Hospital,Jincheng Department of Hepatology,The Third People's Hospital of Taiyuan,Taiyuan Department of Ultrasound,The Third People's Hospital of Taiyuan,Taiyuan Department of Hepatology,The Sixth People's Hospital of Shenyang,Shenyang Sensetime Research Wuxi Hisky Medical Technologies Co. Department of Medical and Marketing,Suzhou Hengrui Medical Devices Co. Shenzhen New Industries Biomedical Engineering Co. Hebei Provincial Key Laboratory of Portal Hypertension and Cirrhosis,Xingtai People's Hospital,Xingtai Department of Radiology,Zhongda Hospital,Southeast University
- 出处 《Portal Hypertension & Cirrhosis》 2025年第3期141-156,共16页
- 基金 funded by the Key Research and Development Program of Jiangsu Province(No.BE2023767a) The Fundamental Research Fund of Southeast University(No.3290002303A2) +5 种基金 Changjiang Scholars Talent Cultivation Project of Zhongda Hospital of Southeast University(No.2023YJXYYRCPY03) Research Personnel Cultivation Programme of Zhongda Hospital Southeast University(No.CZXM-GSP-RC125,CZXM-GSP-RC119) China Postdoctoral Science Foundation(No.2024M750461) National Natural Science Foundation of China(No.82402413) Natural Science Foundation of Jiangsu Province(No.BK20241681) National Natural Science Foundation of China(No.62061160369).
- 摘要 Aims:Bleeding from gastroesophageal varices(GEV)is a medical emergency associated with high mortality.We aim to construct an artificial intelligence-based model of two-dimensional shear wave elastography(2D-SWE)of the liver and spleen to precisely assess the risk of GEV and high-risk GEV(HRV).Methods:This was a multicenter,prospective study conducted from October 2020 to September 2022 across 12 hospitals in China.Patients with compensated advanced chronic liver disease(cACLD)were enrolled,with informed consent obtained.A total of 1136 liver stiffness measurement(LSM)images and 1042 spleen stiffness measurement(SSM)images generated by 2D SWE.Weleveraged deep learning methods to uncover associations between image features and patient risk;in this manner,we constructed models to predict GEV and HRV.Results:A multimodality deep learning risk prediction(DLRP)model was constructed to assess GEV and HRV based on LSM and SSM images and clinical information.Validation analysis revealed that the area under the curve(AUC)values of DLRP were 0.91 for GEV(95%confidence interval[CI],0.90-0.93,p<0.05)and 0.88 for HRV(95%CI,0.86-0.89,p<0.01),which were significantly and robustly better than those of canonical risk indicators,including the values of LSM(0.63 and 0.68 for GEV and HRV)andSSM(0.75for both GEV andHRV).Moreover,the DLRP model outperformed the model using individual parameters.In HRV prediction,the 2D-SWE SSM images(0.75)were more informative than LSM(0.68,p<0.01).Conclusion:Our DLRP model shows excellent performance in predicting GEV and HRV,outperforming the canonical risk indicators LSM and SSM.Additionally,the 2D-SWE SSM images provided more information and thus better accuracy in HRV prediction than the LSM images.
- 关键词 compensated advanced chronic liver disease deep learning gastroesophageal varices high-risk gastroesophageal varices two-dimensional shear wave elastography images
- 分类号 R575.2 [医药卫生—消化系统]
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- 题名Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study 认领 引用 被引量：5
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- 作者 Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi
- 机构 Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases,Zhejiang Provincial Research Center for Diagnosis and Treatment of Heapatobiliary Diseases,Zhejiang University Cancer Center Department of Interventional Therapy,National Cancer Center/National Clinical Research Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Portal Hypertension,Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou Department of Anesthesiology and Operating Theater,The First Hospital of Lanzhou University,Lanzhou Interventional Radiology Department,The First Hospital of Lanzhou University,Lanzhou Department of Gastroenterology,Ankara University School of Medicine Department of Internal Medicine,Istanbul Department of General Surgery,Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province,The First Hospital of Lanzhou University,Lanzhou Nursing Department,The First Hospital of Lanzhou University,Lanzhou Department of General Surgery,Donggang Branch,First Hospital of Lanzhou University,Lanzhou The Diagnosis and Treatment Center of Endoscopy and Interventional Radiology,Department of General Surgery,Donggang Branch,First Hospital of Lanzhou University,Lanzhou Department of Interventional Radiology,Lishui Central Hospital Department of Hepatology and Gastroenterology of The Third Central Hospital of Tianjin Department of Radiology of The Third Central Hospital of Tianjin Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou Department of Hepatobiliary Surgery,Xingtai People's Hospital,Xingtai Department of Gastroenterology,Shandong Provincial Hospital Affiliated to Shandong First Medical University Department of Radiology,Tianjin Second People's Hospital Department of Gastroenterology and Hepatology,Tianjin Second People's Hospital Department of Gastroenterology,Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region Department of Gastroenterology Department of Interventional Radiology,The Third People's Hospital of Taiyuan,Taiyuan Deparment of Hepatology,The Third People's Hospital of Taiyuan,Taiyuan Department of Hepatology,Graduate School of Medicine,Osaka City University Department of Intervention,The Sixth Hospital of Shenyang,Shenyang Department of Gastroenterology,The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Department of Interventional Radiology,The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University Gastroenterology Department,University of Sao Paulo,Sao Paulo Interventional Cardiology Department,Hospital ENCORE,Aparecida de Goiânia Department of Scientific Coordination,Hospital ENCORE,Aparecida de Goiânia Department of Infectious Diseases,The Third Affiliated Hospital of Sun Yat‐Sen University Department of Interventional Radiology,The Third Affiliated Hospital of Sun Yat‐Sen University Department of Hepatology,The Second People's Hospital of Lanzhou City,Lanzhou Department of Radiology,The Second People's Hospital of Lanzhou City,Lanzhou Department of Ultrasonography,The Second People's Hospital of Lanzhou City,Lanzhou Department of Gastroenterology,The People's Hospital of Ningxia Hui Autonomous Region,Yinchuan Center of Portal Hypertension,Department of Radiology,Zhongda Hospital,Southeast University
- 出处 《Portal Hypertension & Cirrhosis》 2022年第1期7-14,共8页
- 基金 Gansu Science Fund for Distinguished Young Scholars,Grant/Award Number:20JR10RA713 Guangxi Digestive Disease Clinical Medical Research Center Construction Project,Grant/Award Number:AD17129027 +7 种基金 Tianjin Science and Technology Plan Project,Grant/Award Number:19ZXDBSY00030 The Xingtai City Science and Technology Project,Grant/Award Number:2020ZZ026 Zhejiang Provincial Natural Science Foundation of China,Grant/Award Number:LZ18H180001 The Hebei Provincial Health and Family Planning Commission Scientific Research Fund Project,Grant/Award Number:20181612 Wenzhou Municipal Science and Technology Bureau,Grant/Award Number:Y2020013 National Natural Science Foundation of China,Grant/Award Numbers:81860654,81971713 The Hebei Provincial Key R&D Program Project,Grant/Award Number:18277717D Natural Science Foundation of Science and Technology Department of Tibet Autonomous Region,Grant/Award Number:XZ2017ZRG‐91。
- 摘要 Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure.
- 关键词 design hypertension multicenter study portal pressure prospective study questionnaire wedge
- 分类号 R575.2 [医药卫生—消化系统]
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- 题名One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China 认领 引用
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- 作者 Jitao Wang Ting Cui Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi
- 机构 Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension,Xingtai People's Hospital,Xingtai Center of Portal Hypertension,Department of Radiology,Zhongda Hospital,School of Medicine,Southeast University Department of Interventional Therapy,Beijing Shijitan Hospital Affiliated to Capital Medical University Department of Intervention,Taiyuan Third People's Hospital,Taiyuan Department of Intervention,Zhongshan Hospital Affiliated to Fudan University Department of Interventional Medicine,The First Hospital of Lanzhou University,Lanzhou Department of Infectious Diseases,Nanfang Hospital of Southern Medical University Hepatobiliary and Pancreatic Intervention Center,The First Affiliated Hospital of Zhejiang University School of Medicine Interventional Vascular Surgery,Hunan Provincial People's Hospital Department of Intervention,Sixth People's Hospital of Shenyang,Shenyang Department of Gastroenterology,West China Hospital of Sichuan University Department of Intervention,The Fourth People's Hospital of Qinghai Province Department of Gastroenterology,Nanjing Drum Tower Hospital Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou Department of Radiology,Shulan（Hangzhou）Hospital Department of Intervention,Mengchao Hepatobiliary Hospital of Fujian Medical University Department of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University Department of Gastroenterology,The First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Department of Gastroenterology,Shandong Provincial Hospital Affiliated to Shandong First Medical University Department of Interventional Radiology,Fifth Medical Center of General Hospital of Chinese People's Liberation Army Department of Interventional Therapy,The First Affiliated Hospital of China Medical University,Shenyang Department of Gastroenterology,Tianjin Third Central Hospital Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University Department of Metabolic Hepatology,Qingdao Sixth People's Hospital,Qingdao Liver Disease Center,Beijing Friendship Hospital,Capital Medical University Department of Intervention,Shanghai Public Health Clinical Center Department of Intervention,People's Hospital of Lishui,Zhejiang Province Department of Interventional Radiology and Vascular Surgery,The Second Affiliated Hospital of Hainan Medical University Department of Radiology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine Department of Intervention,The First Affiliated Hospital of Soochow University Longwan Interventional and Vascular Surgery,Huludao Central Hospital,Huludao Department of Intervention,Ningbo Medical Center Lihuili Hospital Department of Gastroenterology,People's Hospital of Rizhao Department of Gastroenterology,Yangquan Third People's Hospital,Yangquan Department of Infectious Diseases,Taihe Hospital,Shiyan City,Hubei Province Department of Interventional Therapy,Guilin People's Hospital,Guangxi Interventional Vascular Surgery,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan,Ningxia Department of Interventional Therapy,Yantai Yuhuangding Hospital Affiliated to Qingdao University Department of Radiology,Tongji Hospital Department of General Surgery,Donggang Campus,The First Hospital of Lanzhou University,Lanzhou Department of Gastroenterology,The Second Affiliated Hospital of Nanchang University,Nanchang Liver Disease Digestion Center,Beijing You'an Hospital,Capital Medical University Department of Radiology,Tianjin Second People's Hospital Department of Intervention,The Third Affiliated Hospital,Sun Yat‐sen University Second Department of Hepatology,Shenzhen Third People's Hospital Department of Interventional Radiology,The Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Department of Intervention,Zigong Fourth People's Hospital Department of Hepatology,Jiamusi Infectious Disease Hospital,Jiamusi Department of Gastroenterology,Wuhan NO.1 Hospital Interventional Vascular Surgery,Jingzhou First People's Hospital,Jingzhou Interventional Diagnosis and Treatment Center,Lishui Central Hospital Department of Oncological and Vascular Intervention,First Hospital of Shanxi Medical University,Taiyuan Department of Interventional Radiology,People's Hospital of Tibet Autonomous Region Department of Intervention Tumor,The First Affiliated Hospital of University of Science and Technology of China Department of Interventional Radiology,The First Affiliated Hospital,Sun Yatsen University Department of Infectious Diseases,Qufu People's Hospital Interventional and Vascular Surgery,Zhongda Hospital Southeast University Department of Minimally Invasive Intervention,The Second Affiliated Hospital of Guangdong Medical University Department of Gastroenterology,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology Tumor and Vascular Intervention Department,Jinhua Medical Central Hospital Department of Infectious Diseases,The First Affiliated Hospital of Nanchang University,Nanchang Department of Gastroenterology,General Hospital of Ningxia Medical University,Yinchuan,Ningxia Interventional Diagnosis and Treatment Center,Zhoushan Hospital of Zhejiang Province,Zhoushan Department of Interventional Vascular Surgery,The Fifth Affiliated Hospital of Sun Yat‐sen University Department of Interventional Medicine,Zhangzhou Hospital Affiliated to Fujian Medical University,Zhangzhou Department of Hepatobiliary,Pancreatic,and Splenic Surgery,Shunde Hospital of Southern Medical University Department of Gastroenterology,The Affiliated Hospital of Southwest Medical University Department of Hepatobiliary Medicine,The 900th Hospital of the Joint Logistics Support Force Department of Gastroenterology,The Second People's Hospital of Fuyang City,Anhui Province Department of Infectious Diseases,The NO.2 Affiliated Hospital of Air Force Medical University,Shaanxi Department of Gastroenterology,Weinan Central Hospital,Shaanxi Interventional Treatment Center,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Endovascular Surgery,The First Affiliated Hospital of Zhengzhou University Department of Interventional Therapy,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Comprehensive Intervention Department,Hainan General Hospital Department of Gastroenterology,Kuitun Hospital,Xinjiang Department of Interventional Therapy,The First Affiliated Hospital of Dalian Medical University Department of Intervention,Sanming First Hospital Affiliated to Fujian Medical University,Sanming Department of Gastroenterology,Hospital of the People's Government of Tibet Autonomous Region in Chengdu Office Department of Gastroenterology,Fuling Hospital Affiliated to Chongqing University Department of Radiology,Mengzi People's Hospital Department of Gastroenterology,The Third People's Hospital of Mianyang,Mianyang Department of Gastroenterology,Shannan People's Hospital,Shannan Department of Gastroenterology,Hainan Hospital of Chinese PLA General Hospital Department of Intervention,The Second People's Hospital of Lanzhou City,Lanzhou Department of Vascular and Intervention,Nanfang Hospital of Southern Medical University Department of Interventional Radiology,The Affiliated Hospital of Jiangsu University,Zhenjiang
- 出处 《Portal Hypertension & Cirrhosis》 2024年第2期116-123,共8页
- 摘要 Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.
- 关键词 application status hepatic vein pressure gradient questionnaire survey
- 分类号 R575.2 [医药卫生—消化系统]
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