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A durable fluorine-free polyurethane-coated fabric with switchable super-wetting properties under mild pH conditions for controllable oil/water separation 认领 引用
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作者 Junrong Wu Chuyan Lin +4 位作者 Jiale Chen Yingchao Rong Minzimo Song Fengwei Xie Taoyan Mao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第5期363-370,共8页
The development of separation technologies for oil-water mixtures with different specific gravities remains an urgent challenge.In this study,a smart pH-responsive fluorine-free polyurethane was prepared and applied t... The development of separation technologies for oil-water mixtures with different specific gravities remains an urgent challenge.In this study,a smart pH-responsive fluorine-free polyurethane was prepared and applied to fabric via a simple dip-coating method.By utilizing its tunable surface charge under pH 5 and 7,the fabric enabled continuous separation of oil-water mixtures with varying specific gravities and faciliated the recovery of contaminated oil in spill incidents.Notably,the fabric demonstrated excellent oil-water separation efficiency(approximately 95%)and high flux(over 18000L·m-2·h-1for oil).Additionally,the material exhibits excellent antifouling and recyclability properties,along with notable chemical and mechanical stability.These attributes suggest that this coated fabric holds promise as an effective material for treating complex wastewater. 展开更多
关键词 Switchable wettability pH-responsive Fluorine-free Oil/water separation
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Observation on the Effect of Combined Exercise Intervention Based on the Hospital-Community-Family Model on Intrinsic Capacity in Elderly Patients with Diabetes Mellitus Complicated by Chronic Kidney Disease 认领 引用 被引量：1
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作者 Meijie Zheng Wenxiu Liu +6 位作者 Bohan Qu Qiong Meng Ziye Chen Jiale Chen Yongfeng Wang Xian Li Huifeng Jiao 《Journal of Clinical and Nursing Research》 2026年第1期221-230,共10页
Objective:To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney... Objective:To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Methods:Using convenience sampling,100 elderly patients with diabetes mellitus complicated by chronic kidney disease who received treatment in the endocrinology department of a tertiary A-level hospital from May 2024 to May 2025 were selected as the study subjects.They were randomly divided into an experimental group(50 cases)and a control group(50 cases)using a random number table method.The control group received routine health education and telephone follow-up,while the experimental group,in addition to the control group’s interventions,underwent combined exercise intervention based on the hospital-community-family model.Remote medical guidance was utilized to monitor and study the application effect of exercise intervention on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores in five dimensions of intrinsic capacity(exercise,cognition,psychology,vitality,and sensation)were measured before the intervention,at 4 weeks of intervention,and at 12 weeks of intervention for both groups.Results:Before the exercise intervention,there were no statistically significant differences(p>0.05)between the two groups in terms of fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores across five dimensions of intrinsic capacity:mobility,cognition,psychology,vitality,and sensation.After 12 weeks of intervention,the experimental group demonstrated significantly higher scores than the control group in glomerular filtration rate,6-minute walk distance,and the dimensions of mobility,cognition,and vitality within intrinsic capacity,with all differences being statistically significant(p<0.05).Conversely,the experimental group showed significantly lower scores than the control group in fasting blood glucose,2-hour postprandial blood glucose,and the psychological dimension of intrinsic capacity,with these differences also being statistically significant(p<0.05).Conclusion:Continuous nursing care utilizing telemedicine based on a hospital-community-family model combined with exercise intervention can effectively enhance exercise tolerance and intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease,thereby improving their quality of life.The effectiveness of the intervention is positively correlated with the duration of the intervention. 展开更多
关键词 Hospital-community-family model Telemedicine Elderly Diabetes mellitus complicated by chronic kidney disease Intrinsic capacity
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SPIRIT Extension for Chinese Herbal Medicine Formula 2025:Recommendations,explanation,and elaboration 认领 引用
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作者 Pengbo Gao Liu Liu +14 位作者 Jiale Chen Jiao Wang Xiaoce Cai Miao Zhang Chunxiao Wang Naixuan Lin Sihan Wang Yuanting Yu Xiaoying Sun Yuyi Wang Dijiong Wu Haizhen Wang Changhe Yu Weiwen Chen Xin Li 《World Journal of Integrated Traditional and Western Medicine》 2026年第1期101-112,共12页
Objectives:The global use of Chinese herbal medicine formula(CHMF)is increasing,necessitating high-quality clinical trials.However,a lack of specific reporting standards has resulted in inconsistent and incomplete tri... Objectives:The global use of Chinese herbal medicine formula(CHMF)is increasing,necessitating high-quality clinical trials.However,a lack of specific reporting standards has resulted in inconsistent and incomplete trial protocols,thereby undermining the reliability of the evidence.Although the Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018(SPIRIT-TCM Extension 2018)provides general guidance,it is not specifically tailored to CHMF.The objective of the study is to develop dedicated guidelines aimed at improving the completeness and quality of clinical trial protocols for CHMF,based on the latest SPIRIT 2025 statement.Methods:A 17-member multidisciplinary working group comprising traditional Chinese medicine(TCM)clinicians,herbalists,and methodologists developed an extension using a modified nominal group technique.The process comprised three structured facilitator-led discussion cycles and two rounds of written consultation,during which the proposed adaptations to all items were iteratively refined and endorsed by all panel members.Results:The SPIRIT Extension for Chinese Herbal Medicine Formula 2025(SPIRIT-CHMF 2025)was developed.It expands on 15 items from the SPIRIT 2025 checklist,incorporating key CHMF-specific concepts such as TCM syndrome pattern diagnosis,formula composition,and quality control measures.It also provides detailed guidance for sections,including interventions,outcomes,eligibility criteria,and rationale.Conclusions:SPIRIT-CHMF 2025 bridges international trial standards with the unique characteristics of CHMF.Its implementation is expected to standardize protocol development and generate more reliable evidence on the safety and efficacy of TCM. 展开更多
关键词 SPIRIT CHMF extension recommendation traditional Chinese medicine
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Microscopic characteristics and microstructure evolution of loess after explosion 认领 引用
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作者 Dong Tang Longsheng Deng +8 位作者 Wen Fan Bo Yu Zhongdong Du Shuhan Shen Jiale Chen Sixuan Wang Rui Liu Fangshu Song Yu Zou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2025年第11期7380-7396,共17页
The accelerated demand for engineering services has led to the extensive utilization of engineering blasting techniques.Blasting-induced changes in loess microstructure(e.g.particle breakage,pore structure change)dire... The accelerated demand for engineering services has led to the extensive utilization of engineering blasting techniques.Blasting-induced changes in loess microstructure(e.g.particle breakage,pore structure change)directly affect its macroscopic mechanical properties.However,there remains a notable lack of studies on the impact of explosions on loess microstructure and the quantificationof loess microstructure.This study employed micro-computed tomography(μ-CT)technology to examine loess samples extracted from the surrounding area of the explosion cavity,systematically investigating the volume,orientation,and morphological characteristics of particles and pores.The research findings indicated that the explosion caused a break for the particles with a diameter larger than 10μm,and the number of smaller particles increased.Blasting decreased the particle sphericity and orientation angle.The reduction in porosity was primarily attributed to a decrease in the volume of both macropores and mesopores,with a greater reduction in the volume of mesopores.Although the number of micropores increased,the volume change was insignificant.Furthermore,the explosion increased the pore fractal dimension and patch density,suggesting a more complex and fragmented pore structure.Moreover,the pore throat radius and channel length decreased with decreasing distance from the explosion cavity(DEC),indicating that the pore's connectivity reduced.The radius of the blasting cavity was approximately 0.35 m.Additionally,the loess zone surrounding the blasting cavity was divided into failure,plastic,and elastic zones using the DEC=0.2 m and 1.2 m as the boundaries.The impacts of the explosion on loess were mainly within the range of DECless than 1.20 m.The analysis of the traits,patterns,and mechanisms of explosions'impact on the loess's microstructure can provide microscopic insight into the macro-dynamic behavior,assess the impact of explosions on the surrounding loess,and identify the potential geological hazards triggered by blasting,which offers a theoretical foundation for the subsequent engineering design and security measures. 展开更多
关键词 Field explosion test Loess microstructure Variation characteristics and microscopic patterns Micro-computed tomography(μ-CT) scanning
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Revealing spatio-temporal characteristics of ecological resistance surfaces:A regional study case based on coupled algorithms AutoEncoder-XGBoost 认领 引用
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作者 Yeming Lao Xiaorong He +1 位作者 Jiale Chen Youjia Liang 《Ecological Frontiers》 CSCD 2025年第2期422-432,共11页
As regional economy develops rapidly,the ecological environment exposes a series of problems,with the characteristics of ecological resistance surfaces being obviously differentiated.In the context of the increasing a... As regional economy develops rapidly,the ecological environment exposes a series of problems,with the characteristics of ecological resistance surfaces being obviously differentiated.In the context of the increasing advance in computer science,this research introduced a deep learning algorithm,AutoEncoder,to analyze the ecological resistance surfaces over a 20-year period in 23 counties and districts in the Three Gorges Reservoir Area.The main results are as follows:(1)the overall resistance surfaces were at a low level,with high values concentrated in the core urban areas and along the Yangtze River.(2)The spatial distributions of the AutoEncoder results were smoother and more focused compared to the results of analytic hierarchy process.(3)The XGBoost detection results indicated land cover types as the highest contributing factor to the resistance.(4)Habitat quality analysis revealed a high degree of spatial heterogeneity,with the northeastern regions exhibiting more favorable conditions and the densely populated urban centers in the southwest displaying degraded quality.(5)The regionalization analysis outlined key conservation area,key restoration area and moderate development area,proposing a strategic framework of“One Axis,Two Zones and Four Protection Screens”for guiding the long-term ecological development in the research region. 展开更多
关键词 Resistance surfaces Habitat quality AutoEncoder XGBoost Eological regionalization Ecological development planning
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GENERALIZED COUNTING FUNCTIONS AND COMPOSITION OPERATORS ON WEIGHTED BERGMAN SPACES OF DIRICHLET SERIES 认领 引用
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作者 Min HE Maofa WANG Jiale CHEN 《Acta Mathematica Scientia》 SCIE CSCD 2025年第2期291-309,共19页
In this paper,we study composition operators on weighted Bergman spaces of Dirichlet series.We first establish some Littlewood-type inequalities for generalized mean counting functions.Then we give sufficient conditio... In this paper,we study composition operators on weighted Bergman spaces of Dirichlet series.We first establish some Littlewood-type inequalities for generalized mean counting functions.Then we give sufficient conditions for a composition operator with zero characteristic to be bounded or compact on weighted Bergman spaces of Dirichlet series.The corresponding sufficient condition for compactness in the case of positive characteristics is also obtained. 展开更多
关键词 generalized counting function Dirichlet series composition operator weighted Bergman space
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基于肠道菌群-色氨酸代谢探讨结直肠癌发生发展的机制研究进展 认领 引用
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作者 张早育 李莹 +2 位作者 邓蓉 陈佳乐 李彦龙 《中国肿瘤临床》 CAS CSCD 北大核心 2025年第21期1128-1132,共5页
结直肠癌(colorectal cancer,CRC)是全球范围内高发的恶性肿瘤之一,其发病机制涉及遗传、表观遗传、环境及微生物等多因素。近年来,肠道菌群与宿主代谢的相互作用在CRC发生发展中的作用备受关注,并且肠道菌群及微环境在疾病的发生发展... 结直肠癌(colorectal cancer,CRC)是全球范围内高发的恶性肿瘤之一,其发病机制涉及遗传、表观遗传、环境及微生物等多因素。近年来,肠道菌群与宿主代谢的相互作用在CRC发生发展中的作用备受关注,并且肠道菌群及微环境在疾病的发生发展中占据着关键地位。色氨酸(Tryptophan,Trp)作为人体必需氨基酸,其代谢产物通过宿主酶及微生物代谢途径参与免疫调节、炎症反应及肿瘤微环境调控。本文就肠道菌群调控色氨酸代谢的关键途径(如犬尿氨酸途径、5-羟色胺途径及吲哚类衍生物途径)在CRC中的作用进行综述,探讨菌群失衡(如具核梭杆菌、脆弱拟杆菌等促癌菌富集)如何通过影响色氨酸代谢促进CRC进展,并展望基于菌群代谢轴的新型CRC防治策略,以期为CRC机制研究及临床诊治提供一定的参考意义。 展开更多
关键词 结直肠癌 肠道菌群 色氨酸代谢 犬尿氨酸 吲哚衍生物
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Impact of Ti/Teratio on ion transport based on EAST H-mode plasmas 认领 引用
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作者 Jianwen LIU Qing ZANG +14 位作者 Yunfeng LIANG Jiale CHEN Xiaohe WU Alexander KNIEPS Jiahui HU Yifei JIN Bin ZHANG Yuqi CHU Haiqing LIU Bo LYU Yanmin DUAN Miaohui LI Yingjie CHEN Xianzu GONG the EAST Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第4期68-78,共11页
At the EAST tokamak,the ion temperature(Ti)is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas,even at core electron temperatures up to 10 keV(depending on the ECR heating ... At the EAST tokamak,the ion temperature(Ti)is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas,even at core electron temperatures up to 10 keV(depending on the ECR heating power and the plasma density).This clamping results from the lack of direct ion heating and high levels of turbulence-driven transport.Turbulent transport analysis shows that trapped electron mode and electron temperature gradient-driven modes are the most unstable modes in the core of ECR-heated H-mode plasmas.Nevertheless,recently it was found that the Ti/Teratio can increase further with the fraction of the neutral beam injection(NBI)power,which leads to a higher core ion temperature(Ti0).In NBI heating-dominant H-mode plasmas,the ion temperature gradient-driven modes become the most unstable modes.Furthermore,a strong and broad internal transport barrier(ITB)can form at the plasma core in high-power NBI-heated H-mode plasmas when the Ti/Teratio approaches~1,which results in steep core Teand Tiprofiles,as well as a peaked neprofile.Power balance analysis shows a weaker Teprofile stiffness after the formation of ITBs in the core plasma region,where Ticlamping is broken,and the core Tican increase further above 2 keV,which is 80%higher than the value of Ticlamping in ECR-heated plasmas.This finding proposes a possible solution to the problem of Ticlamping on EAST and demonstrates an advanced operational regime with the formation of a strong and broad ITB for future fusion plasmas dominated by electron heating. 展开更多
关键词 ion temperature clamping transport neutral beam injection stiffness internal transport barrier
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Impact of core electron temperature on current profile broadening with radiofrequency wave heating and current drive in EAST 认领 引用
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作者 Jiayuan ZHANG Jinping QIAN +11 位作者 Xianzu GONG Bin ZHANG Muquan WU Miaohui LI Jiale CHEN Qing ZANG Shiyao LIN Yan CHAO Hailin ZHAO Ruirong LIANG Tianqi JIA Yunchan HU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第10期23-29,共7页
In recent EAST experiments,current profile broadening characterized by reduced internal inductance has been achieved by utilizing radio-frequency current drives(RFCD).In contrast to previous density scan experiments,w... In recent EAST experiments,current profile broadening characterized by reduced internal inductance has been achieved by utilizing radio-frequency current drives(RFCD).In contrast to previous density scan experiments,which showed an outward shift of the current density profile of lower hybrid current drive(LHCD)in higher plasma density,the core electron temperature(Te(0))is found to affect the LHCD current profile as well.According to equilibrium reconstruction,a significant increase in on-axis safety factor(q0)from 2.05 to 3.41 is observed by careful arrangement of RFCD.Simulations using ray-tracing code GENRAY and Fokker–Planck code CQL3D have been performed to thoroughly analyze the LHCD current profile,revealing the sensitivity of the LHCD current profile to Te(0).The LHCD current density tends to accumulate in the plasma core with higher current drive efficiency benefiting from higher Te(0).With a lower Te(0),the LHCD current profile broadens due to off-axis deposition of power density.The sensitivity of the power deposition and current profile of LHCD to Te(0)provides a promising way to effectively optimize current profile via control of the core electron temperature. 展开更多
关键词 current profile broadening equilibrium reconstruction core electron temperature lower hybrid wave
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Simulations of energetic alpha particle loss in the presence of toroidal field ripple in the CFETR tokamak 认领 引用
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作者 Yingfeng XU Debing ZHANG +1 位作者 Jiale CHEN Fangchuan ZHONG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第10期12-22,共11页
Energetic alpha particle losses with the toroidal field ripple and the Coulomb collision in the CFETR tokamak have been simulated by using the orbit-following code GYCAVA for the steady-state and hybrid scenarios.The ... Energetic alpha particle losses with the toroidal field ripple and the Coulomb collision in the CFETR tokamak have been simulated by using the orbit-following code GYCAVA for the steady-state and hybrid scenarios.The effects of the outer boundary and the ripple amplitude on alpha particle losses have been investigated.The loss fractions and heat loads of alpha particles in the hybrid scenario are much smaller than those in the steady-state scenario for a significant ripple amplitude.Some alpha particles in the plasma core are lost due to the ripple stochastic transport for a large ripple amplitude parameter.The heat loads with the last closed flux surface boundary are different from those with the wall boundary for the CFETR tokamak,which can be explained by typical alpha particle orbits.Discrete heat load spots have been observed in alpha particle loss simulations,which is due to the ripple well loss.The transition of the lost alpha particle behavior from the ripple stochastic diffusion to the ripple well trapping has been identified in our CFETR simulations.The Coulomb collision effect is responsible for this transition. 展开更多
关键词 CFETR toroidal field ripple orbit-following code alpha particle loss
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Research Progress of microRNA in the Diagnosis of Tuberculous Pleurisy 认领 引用
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作者 Surui Chen Xinyu Li +3 位作者 Jiale Chen Yunnan Shen Boyu Hui Wei Wu 《Journal of Biosciences and Medicines》 2024年第7期160-169,共10页
Tuberculosis has become a major public health and social problem threatening human health, and a large proportion of pulmonary tuberculosis patients are associated with tuberculous pleurisy (TP). Therefore, it is of g... Tuberculosis has become a major public health and social problem threatening human health, and a large proportion of pulmonary tuberculosis patients are associated with tuberculous pleurisy (TP). Therefore, it is of great significance to find markers with high specificity and sensitivity for the rapid and accurate diagnosis and differential diagnosis of TP under the severe background of high infectivity and mortality due to the occult nature of TP. The extraction of microRNA (miRNA) from pleural effusion satisfies the characteristics of strong operability. miRNA exists not only in cells, but also in various body fluids and participates in the pathophysiological process of various diseases including infectious diseases. miRNA is a highly specific biomarker in pleural fluid in patients with TP. Therefore, this article provides a review of the research progress of mRNA in tuberculous pleurisy. 展开更多
关键词 Tuberculous Pleurisy miRNA Diagnosis
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Facile fabrication of durable superhydrophobic fabrics by silicon polyurethane membrane for oil/water separation 认领 引用
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作者 Taoyan Mao Runhui Xiao +5 位作者 Peng Liu Jiale Chen Junqiang Luo Su Luo Fengwei Xie Cheng Zheng 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第3期73-83,共11页
Nowadays, oil contamination has become a major reason for water pollution, and presents a global environmental challenge. Although many efforts have been devoted to the fabrication of oil/water separation materials, t... Nowadays, oil contamination has become a major reason for water pollution, and presents a global environmental challenge. Although many efforts have been devoted to the fabrication of oil/water separation materials, their practical applications are still hindered by their weak durability, poor chemical tolerance,environmental resistance, and potential negative impact on health and the environment. To overcome these drawbacks, this work offers a facile method to fabricate the eco-friendly and durable oil/water separation membrane fabrics by alkaline hydrolysis and silicon polyurethane coating. The X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy results demonstrate that silicon polyurethane membrane could be coated onto the surface of hydrolyzed polyester fabric and form a micro-ano-scaled hierarchical structure. Based on this, the modified fabric could have a stable superhydrophobic property with a water contact angle higher than 150°, even after repeated washing and mechanical abrasion 800 times, as well as chemical corrosion. Moreover, the modified fabrics show excellent oil/water separation efficiency of up to 99% for various types of oil–water mixture. Therefore, this durable, eco-friendly and cost-efficient superhydrophobic fabric has great potential in large-scale oil/water separation. 展开更多
关键词 Superhydrophobic fabrics Silicon polyurethane membrane Durability Separation Polymers Waster water
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Kinetic equilibrium reconstruction for the NBI-and ICRH-heated H-mode plasma on EAST tokamak 认领 引用
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作者 Zhen ZHENG Nong XIANG +8 位作者 Jiale CHEN Siye DING Hongfei DU Guoqiang LI Yifeng WANG Haiqing LIU Yingying LI Bo LYU Qing ZANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第6期30-38,共9页
The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode disc... The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode discharge with different auxiliary heatings are reconstructed by using magnetic diagnostics,kinetic diagnostics and TRANSP code.It is found that the fast-ion pressure might be up to one-third of the plasma pressure and the contribution is mainly in the core plasma due to the neutral beam injection power is primarily deposited in the core region.The fast-ion current contributes mainly in the core region while contributes little to the pedestal current.A steep pressure gradient in the pedestal is observed which gives rise to a strong edge current.It is proved that the fast ion effects cannot be ignored and should be considered in the future study of EAST. 展开更多
关键词 kinetic equilibrium reconstruction NBI ICRH pressure gradient edge current fast ions
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Evaluation of NBI absorption and fast ion stored energy to improve thermal energy confinement time calculation in EAST 认领 引用
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作者 Xiang GU Biao SHEN +13 位作者 Jinping QIAN Siye DING Hongfei DU Youwen SUN Bingjia XIAO Bin WU Jinfang WANG Juan HUANG Jiale CHEN Kai LI Guoqiang LI Dalong CHEN Shuliang CHEN Muquan WU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2020年第2期54-59,共6页
The absorption of neutral beam power and the fast ion stored energy in EAST plasmas with neutral beam injection(NBI)is analyzed to improve the calculation of thermal energy confinement time.The neutral beam power abso... The absorption of neutral beam power and the fast ion stored energy in EAST plasmas with neutral beam injection(NBI)is analyzed to improve the calculation of thermal energy confinement time.The neutral beam power absorption and fast ion stored energy are systematically calculated using the TRANSP code,through the investigation of global parameters including plasma current,line averaged density and beam energy.Results have shown that scaling laws for the NBI absorption coefficient and fast ion energy rate are obtained through statistical analysis.A comparison of the confinement improvement factor H98y2 with these new scaling laws against those assuming fixed coefficients is given. 展开更多
关键词 thermal energy confinement time neutral beam absorption fast ion energy
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Estimation of China Fusion Engineering Test Reactor performance and burning fraction in different pellet fueling scenarios by a multi-species radial transport model 认领 引用
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作者 Weisheng LIN Xiaogang WANG +5 位作者 Xueqiao XU Defeng KONG Yumin WANG Jiale CHEN Zhanhui WANG Chijie XIAO 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第5期102-111,共10页
Tritium self-sufficiency in future deuterium–tritium fusion reactors is a crucial challenge.As an engineering test reactor,the China Fusion Engineering Test Reactor requires a burning fraction of 3%for the goal to te... Tritium self-sufficiency in future deuterium–tritium fusion reactors is a crucial challenge.As an engineering test reactor,the China Fusion Engineering Test Reactor requires a burning fraction of 3%for the goal to test the accessibility to the future fusion plant.To self-consistently simulate burning plasmas with profile changes in pellet injection scenarios and to estimate the corresponding burning fraction,a one-dimensional multi-species radial transport model is developed in the BOUT++framework.Several pellet-fueling scenarios are then tested in the model.The results show that the increased fueling depth improves the burning fraction by particle confinement improvement and fusion power increase.Nevertheless,by increasing the depth,the pellet cooling-down may significantly lower the temperature in the core region.Taking the density perturbation into consideration,the reasonable parameters of the fueling scenario in these simulations are estimated as pellet radius rp=3 mm,injection rate=4 Hz,and pellet injection velocity=1000–2000 m s-1 without drift or 450 m s-1 with high-field-side drift. 展开更多
关键词 CFETR tritium burning fraction fueling scenarios
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Parametric decay instabilities of lower hybrid waves on CFETR 认领 引用
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作者 Taotao Zhou Nong Xiang +2 位作者 Chunyun Gan Guozhang Jia Jiale Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第9期386-396,共11页
The lower hybrid current drive is a potential candidate for sustaining plasma current in tokamak steady-state oper-ations,which could be used in China Fusion Engineering Test Reactor(CFETR)with input power up to a few... The lower hybrid current drive is a potential candidate for sustaining plasma current in tokamak steady-state oper-ations,which could be used in China Fusion Engineering Test Reactor(CFETR)with input power up to a few tens of megawatts.Such high input power could trigger the well-known parametric instabilities(PIs)at the plasma edge affect-ing the propagation and absorption of the lower hybrid pump waves.By analytically solving the nonlinear dispersion relation describing PIs,an explicit expression of the PI growth rate is obtained and analyzed in detail.It is found that pressure is the key parameter determining the PI characteristics.Ion sound quasi-mode is the dominant decay channel in the low-pressure regime,while the ion cyclotron quasi-mode(ICQM),as well as its harmonics,becomes dominant in the intermediate regime.In the high-pressure regime,only one mixed channel is found,which is related to Landau damping by free-streaming ions.Analytical expressions of growth rates of these decay channels are also obtained to show the parameter dependence at different pressure limits.The above analytical results are used to estimate the PIs on a typical profile of CFETR,and verified by corresponding numerical calculations.ICQM is found to be the strongest decay channel with a considerable growth rate for CFETR. 展开更多
关键词 lower hybrid parametric instability CFETR
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Analysis on the Infectious Characteristics of African Swine Fever Virus 认领 引用
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作者 Xinglong ZHOU Yue CHEN +4 位作者 Weiqing LI Jiale CHEN Liying SHAO Xin MU Suohua ZHAO 《Agricultural Biotechnology》 2020年第6期31-32,共2页
African swine fever virus(ASFV)is the only pathogen that causes African swine fever(ASF).The virus has strong viability outside of pigs,easily causing cross-border transmission,and bringing great harm to the pig indus... African swine fever virus(ASFV)is the only pathogen that causes African swine fever(ASF).The virus has strong viability outside of pigs,easily causing cross-border transmission,and bringing great harm to the pig industry.This paper mainly introduced the biological characteristics and transmission methods of ASFV,and provides a certain theoretical basis for preventing ASF. 展开更多
关键词 African seine fever Virus Source cf infecico Source of pollution Route cf transmission
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Generalization of negative memories drives the development of psychological distress-related behaviors 认领 引用
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作者 Xin Cheng Yubo Hu +14 位作者 Yan Zhao Panwu Zhao Jiale Chen Xiaomeng Bai Yi Chen Deshan Kong Chuan Xiao Youhua Xu Shuyu Zheng Yuena Zheng Yumeng Wang Hu Zhao Yanni Zeng Wei-Jye Lin Xiaojing Ye 《The Innovation》 EI 2026年第7期48-62,共15页
Individuals with depression and anxiety often exhibit intensified and overgeneralized negative memories.However,the causal contribution of memory features,especially the relative roles of memory strengthening versus g... Individuals with depression and anxiety often exhibit intensified and overgeneralized negative memories.However,the causal contribution of memory features,especially the relative roles of memory strengthening versus generalization in shaping subsequent affective disturbances,remains poorly understood.Here,we developed behavioral paradigms to dissociate memory generalization from strengthening and found that negative experiences leading to memory overgeneralization,but not those enhancing memory strength alone,triggered stress-related behaviors in mice.We identified the projection from medial prefrontal cortex(mPFC)to the bed nucleus of the stria terminalis(BNST)as a key circuit linking generalized memory to stress-related phenotypes.Single-cell calcium imaging revealed a significant overlap between the BNST-projecting mPFC(mPFCBNST)neuronal ensemble encoding stress-related behaviors and that encoding generalized memory,but not memory strength.Circuit-specific transcriptomic profiling,chromophore-assisted light inactivation,and short hairpin RNA-mediated gene knockdown further demonstrated that actin cytoskeleton remodeling within the mPFCBNSTneurons,a molecular event underlying the formation of memory generalization,is essential for the emergence of stress-related behaviors.Collectively,these findings identify the generalization of negative memories as a principal driver of stress-related behaviors.More broadly,they provide mechanistic insight into how overgeneralized negative memories,a cognitive feature commonly observed in psychological disorders,may contribute to vulnerability to psychological distress,thereby offering a conceptual framework relevant to early identification and intervention in affective disorders. 展开更多
关键词 negative experiences Bed Nucleus Stria Terminalis behavioral paradigms Negative Memories Medial Prefrontal Cortex Memory Generalization Cognitive Feature Stress Related Behaviors
Monoculm1 confers cold tolerance at the seedling stage in rice 认领 引用 被引量：1
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作者 Ruiqing Li Chenfan Zheng +14 位作者 Binqiang Wang Shang Dai Yue Song Huali Zhang Zhiguo E Bo Liu Jiale Chen Can Zhang Haowei Fu Ning Xu Liangyong Ma Qian-HaoZhu Vasileios Fotopoulos Qingyao Shu Meng Jiang 《Molecular Plant》 SCIE CAS CSCD 2026年第1期81-99,共19页
Transcriptional regulation of cold-responsive genes plays crucial roles in plant cold tolerance,but the transcription factors(TFs)-centered regulatory networks remain largely unclear.In this study,we show that Monocul... Transcriptional regulation of cold-responsive genes plays crucial roles in plant cold tolerance,but the transcription factors(TFs)-centered regulatory networks remain largely unclear.In this study,we show that Monoculm1(MOC1),a critical TF controlling tiller number and plant height in rice,positively regulates rice cold tolerance at the seedling stage.We found that OsMPK4,a mitogen-activated protein kinase,phosphorylates and stabilizes MOC1 under cold stress.Further investigations revealed that MOC1 recruits the TFs OsbZIP79 and OsNAC5 to form a triple complex and subsequently enhances their stability by inhibiting proteasome-mediated degradation under cold stress.Notably,we found that the OsbZIP79-MOC1-OsNAC5 complex activates several cold-responsive genes,including Dehydration-responsive element-binding factor 1G(OsDREB1G),to confer rice cold tolerance.Haplotype analysis of the OsDREB1G promoter in>10,000 rice accessions identified the favorable haplotype and key variants that endow rice cold tolerance.Collectively,our work demonstrates a pivotal role of the OsMPK4-OsbZIP79-MOC1-OsNAC5-OsDREB1G module in regulating rice cold tolerance and provides genetic targets for improving cold tolerance through molecular breeding. 展开更多
关键词 cold stress transcription factor DREB1G phosphorylation haplotype
Acquired resistance of cancer therapies:Mechanisms and perspectives 认领 引用
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作者 Manli Wang Xiaoqian Zhai +6 位作者 Jiayao Li Jiale Chen Xiyue Gai Xunxi Liu Yu Liu Qinghua Zhou Chong Chen 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第9期1272-1302,共31页
Over the past decades,significant progress has been made in cancer treatment,including chemotherapy,targeted therapy,andmore recently,immunotherapy.However,only a limited number of patients achieve cure with these the... Over the past decades,significant progress has been made in cancer treatment,including chemotherapy,targeted therapy,andmore recently,immunotherapy.However,only a limited number of patients achieve cure with these therapies.A major challengelies in acquired resistance to cancer treatments,where patients initially respond but eventually develop resistance and relapse.Theunderlying mechanisms of acquired resistance are still emerging,encompassing both tumor cell-intrinsic and extrinsic factors,such as the selection of pre-existing resistant clones,acquired genetic mutations,and alterations in the tumor microenvironment.In recent years,several new concepts and significant advances have emerged in this field,such as epigenetic alterations,lineageplasticity,metabolic reprogramming,and cellular crosstalk and signaling within the tumor microenvironment.This review systematicallysummarizes these advances,aiming to provide a comprehensive theoretical framework that integrates emerging conceptsof resistance,while also offering a translational perspective focused on identifying actionable therapeutic targets and guiding thedevelopment of next-generation combination strategies to prevent or overcome acquired resistance in the clinic. 展开更多
关键词 Cancer Chemotherapy Immunotherapy Targeted therpay Acquired resistance Mechanisms Lineage plasticity
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