Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-me...Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-ments in karst hydrology,significant gaps remain in long-term trends,underlying processes,and quantitative effects of environmental changes.This is especially true in areas like the Wujiang River(WJ)in China,where human activities such as reservoir construction and land use/cover changes have accelerated hydrochemical changes.We combined recent and historical monitoring data to provide a detailed analysis of the spatial and temporal characteristics,evolution,and controlling factors of major ions in WJ.These findings are important for local water management and contribute to global efforts to manage similar karst systems facing human-induced pressures.Our research shows clear seasonal differences in solute concentrations,with higher levels during the dry season.WJ’s water is rich in calcium,with Ca-HCO3 ion pairs being the most common.Reservoir monitor-ing stations show much higher levels of NO3−and SO42−compared to river-type stations,likely due to longer hydraulic retention time and increased acid deposition.The study confirms the significant role of pH and water temperature in rock weathering processes.Land use/cover changes were identified as the primary drivers of solute variations(46.37%),followed by lithology(13.92%)and temperature(8.35%).Over the past two decades,in-tense carbonate weathering has been observed,especially during wet seasons.Among karstic provinces,Guizhou Province stands out with the highest ion concentrations,indicative of its extensive karst coverage and heightened weathering processes.展开更多
With the rapid development of artificial intelligence(AI)and multimodal imaging technology,intelligent surgical navigation systems have become a research hotspot in the field of precision tumor treatment.Due to clinic...With the rapid development of artificial intelligence(AI)and multimodal imaging technology,intelligent surgical navigation systems have become a research hotspot in the field of precision tumor treatment.Due to clinical characteristics of tumor surgery—such as blurred lesion boundaries,complex anatomical structures,and high requirements for functional preservation—there are higher demands for precision,real-time performance,and adaptability of surgical navigation.This article analyzes the current development status of tumor surgery navigation platforms both in China and internationally,outlines the core components of intelligent surgical navigation systems,delves into the key technical issues in the application of existing surgery navigation systems in tumor treatment and the driving role of AI technology,discusses the urgent problems to be solved in tumor surgical navigation systems,and provides an outlook on the technological development trends of intelligent tumor surgery navigation systems.展开更多
Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam expl...Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.展开更多
The rapid growth of networked systems and the increasing diversity of cyberattack behaviors have posed significant challenges to intrusion detection,particularly in scenarios characterized by high-dimensional features...The rapid growth of networked systems and the increasing diversity of cyberattack behaviors have posed significant challenges to intrusion detection,particularly in scenarios characterized by high-dimensional features and severe class imbalance.Conventional detection approaches based on handcrafted rules or shallow representations often exhibit limited robustness under such conditions.To address these issues,this paper presents a hybrid deep learning framework for network intrusion detection that integrates complementary feature learning mechanisms within a dual-branch architecture.Specifically,a Transformer branch is employed to model long-range temporal dependencies in network traffic,while a convolutional neural network branch(CNN)is used to capture localized and fine-grained feature patterns.An attention-based fusion strategy is further introduced to adaptively aggregate branch-specific representations and enhance intrusion-sensitive features.In addition,an autoencoder-based feature reconstruction module is incorporated before the dual-branch network to compress and reconstruct input features through an encoder-decoder structure,thereby preserving essential behavioral characteristics of network traffic and improving feature discriminability.To mitigate the impact of class imbalance,a Dynamic Weighted Logit-adjusted Focal Loss(DWLF)is introduced to reduce the bias toward majority classes during model optimization.Extensive experiments conducted on two public benchmark datasets demonstrate the effectiveness of the proposed approach.The proposed model achieves an overall accuracy of 90.01%on the UNSW-NB15 dataset and 97.82%on the NF-CSE-CIC-IDS2018 dataset.Experimental results indicate improved robustness under highly imbalanced data distributions,demonstrating stable performance across datasets with different traffic characteristics.展开更多
Highly responsive near-infrared(NIR)photodetectors(PDs)are increasingly required for advanced photoelectric systems.While silicon-based detectors benefit from mature fabrication and CMOS compatibility,their performanc...Highly responsive near-infrared(NIR)photodetectors(PDs)are increasingly required for advanced photoelectric systems.While silicon-based detectors benefit from mature fabrication and CMOS compatibility,their performance is limited by the intrinsic bandgap of 1.12 eV,which leads to weak responsivity in the NIR band.Herein,a high-responsivity silicon-based NIR PD is proposed by incorporating a heterostructure of black silicon(B-Si)and PtTe2.The B-Si integrated in the photosensitive region of a Si p-i-n diode introduces sub-bandgap defect states,significantly enhancing NIR absorption.Further,the PtTe2film coated onto the B-Si surface induces energy band bending and enhances the interfacial electric field,which together promote the separation and collection of photogenerated carriers.Additionally,the PtTe2film forms a passivation layer on the B-Si surface,which repairs surface defects and suppresses carrier recombination,thereby reducing the dark current of the device.The PtTe2/B-Si PD demonstrates remarkable NIR detection performance,achieving a responsivity of 0.64 A W–1at 1064 nm and showing a 146%improvement over conventional silicon photodiodes,while maintaining excellent detectivity(D*)of 3.54×1011Jones.This performance underscores the device's capability for weak-light detection and positions it as a viable candidate for CMOS-integrated NIR photonics.展开更多
BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(S...BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are unclear.AIM To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric hospital.METHODS We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan’s Youfu Hospital.RESULTS Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison group.The overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were male.The most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for COVID-19.SCZ patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between individuals.CONCLUSION Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.展开更多
Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D...Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D printing,and numerical control machining are reshaping the workflow of complete denture restoration.Unlike conventional methods that rely heavily on clinical experience and manual techniques,digital technologies offer greater precision,predictability,and efficacy.They also streamline the process by reducing the number of patient visits and improving overall comfort.Despite these improvements,the clinical application of digital complete denture restoration still faces challenges that require further standardization.The major issues include appropriate case selection,establishing consistent digital workflows,and evaluating long-term outcomes.To address these challenges and provide clinical guidance for practitioners,this expert consensus outlines the principles,advantages,and limitations of digital complete denture technology.The aim of this review was to offer practical recommendations on indications,clinical procedures and precautions,evaluation metrics,and outcome assessment to support digital restoration of complete denture in clinical practice.展开更多
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe n...Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.Ferroptosis is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic stroke.However,there are few studies on oligodendrocyte progenitor cell ferroptosis.We analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral ischemia.Bioinformatics analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ferroptosis.PLIN2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet accumulation.For further investigation,we established a mouse model of cerebral ischemiaeperfusion.We found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct area.The ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin injury.We also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor cells.Plin2 knockdown rescued demyelination and improved neurological deficits.Our findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.展开更多
Polymeric materials which can undergo controlled degradation and recycling are of great significance for a sustainable society.Although tremendous progress has been made in the degradation and recycling of both thermo...Polymeric materials which can undergo controlled degradation and recycling are of great significance for a sustainable society.Although tremendous progress has been made in the degradation and recycling of both thermoplastic and thermoset plastics,the development of high-performance degradable polymer adhesives is rare.Here,we have prepared high-performance nucleobase-containing thioctic acid-based supramolecular polymer adhesives through free radical polymerization.The specific hydrogen-bonding interactions between complementary nucleobases greatly improve the weak cohesion of the thioctic acid-based polymers and enhance the environmental stability of the thioctic acidbased polymers simultaneously.Degradation of the nucleobase-containing thioctic acid-based supramolecular polymers is achieved by the reduction of the disulfide backbone,and the cycle of degradation and repolymerization is further achieved via oxidative polymerization.The adhesion strength of the nucleobase-containing thioctic acid-based supramolecular polymers after two cycles of degradation and repolymerization still reaches as high as 4.7±0.3 MPa.This work provides an approach for the development of environmentally stable and high-performance degradable thioctic acid-based adhesives.展开更多
Cyber-physical system(CPS)is a networked,intelligent system that tightly integrates physical systems with cutting-edge information technologies to achieve efficient and secure operations.It is widely regarded as a cor...Cyber-physical system(CPS)is a networked,intelligent system that tightly integrates physical systems with cutting-edge information technologies to achieve efficient and secure operations.It is widely regarded as a cor-nerstone of the Fourth Industrial Revolution.The global energy industry is undergoing a period of profound change marked by large-scale integration of renewable energy,multi-energy synergy,and the proliferation of distributed energy resources,which in turn heightens energy system complexity and uncertainty,creating sig-nificant challenges for system design and operation.Cyber-physical energy system(CPES)-a CPS tailored to the energy sector-provides a digital-physical infrastructure for efficient,secure production and consumption of energy under uncertainty,which offers a comprehensive solution for system design and operation.This pa-per presents a conceptual framework for CPES,outlines the typical structure and design/operation paradigms,and reports on an operational pilot implementation project.It further identifies key challenges in modeling and design,scheduling,control,as well as safety and security as priorities for future research.展开更多
Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst an...Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H*migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C8-C14branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.展开更多
Benzotriazole(BTA)-based A2-A_1-D-A_1-A2type wide-bandgap(WBG)non-fullerene acceptors(NFAs)have shown promising potential in indoor photovoltaic,and in-depth investigation of their structure-property relationshi...Benzotriazole(BTA)-based A2-A_1-D-A_1-A2type wide-bandgap(WBG)non-fullerene acceptors(NFAs)have shown promising potential in indoor photovoltaic,and in-depth investigation of their structure-property relationship is of great significance.Herein,we explored the chlorination effect of the side chain on the terminals.We introduced Cl atoms into the benzyl side chains in parent BTA5 to synthesize two NFAs,BTA5-Cl with mono-chlorinated benzyl groups and BTA5-2Cl containing bi-chlorinated benzyl groups.We chose D18-Cl with deep-energy levels and strong crystallinity to pair with these three acceptors,affording high photovoltage and photocurrent.With the stepwise chlorination,the open-circuit voltage(VOC)values decrease from 1.28,1.22,to 1.20 V,while the corresponding power conversion efficiencies(PCEs)improve from 5.07%,9.15%,to 10.96%.Compared with BTA5-based OSCs,introducing Cl atoms downshifts the energy levels and slightly increases the non-radiative energy loss(0.14<0.17<0.19 e V),resulting in a sequential decrease in VO C.However,more chlorine atom replacements produce more effective exciton dissociation,higher charge transfer,and balanced carrier mobility in the blend films,ultimately achieving better PCEs.This work indicates that chlorination of the benzyl group on the terminals can improve the device's performance,implying good application potential in indoor photovoltaics.展开更多
Objectives:Recently,pre-/post-operative Local Estrogen Therapy(LET)has shown effectiveness in alleviating Pelvic Organ Prolapse(POP)symptoms in clinical therapy.However,there is a lack of scientific evidence to suppor...Objectives:Recently,pre-/post-operative Local Estrogen Therapy(LET)has shown effectiveness in alleviating Pelvic Organ Prolapse(POP)symptoms in clinical therapy.However,there is a lack of scientific evidence to support these claims.Therefore,we aimed to explore the anti-senescence effects and mechanisms of 17β-estradiol(E2)on POP-derived fibroblasts.Methods:The primary fibroblast cells were isolated and cultured fromthe surgical samples of postmenopausal women clinically diagnosed with pelvic organ prolapse(POP)at stages III-IV(quantified using the POP-Q system)and without any other treatment within 6 months.(n=12,age 50–75).Colorimetric Cell Counting Kit(CCK-8)assay and Senescence-Associated-β-Galactosidase(SA-β-Gal)staining were used to test the cell proliferative capacity and the senescence rate.Western blotting(WB)was used to detect the expression of Collagen Type I(COL-I),Collagen Type III(COL-III),Cyclin-dependent kinase 4 inhibitor A(p16INK4a),Cyclin-dependent kinase inhibitor 1A(p21),Tumor Protein 53(p53),Sirtuin 1(SIRT-1)and Microtubule-associated protein 1A/1B-light chain 3-I/II(LC3-I/II)protein.A transmission ElectronMicroscope(TEM)was used to observe the ultrastructure of fibroblasts.Results:The results showed that E2 significantly promoted the proliferation of fibroblasts derived from POP and reduced the staining rate of SA-β-Gal.It markedly enhanced the extracellular matrix proteins COL-I and COL-III,accompanied by inhibition of the senescent maker p16INK4a.Additionally,our results improved the cells’autophagy and metabolic activity.Additionally,our results indicate the anti-senescence mechanism of E2 through the mediated SIRT-1/p53/p21 axis pathway.Conclusion:We provide preliminary evidence for the anti-aging effects and mechanisms of E2 on POP,hoping to provide a theoretical basis for estrogen against POP senescence and guide the clinical application and local administration of estrogen in POP treatment.展开更多
This work proposes a novel design for a narrowband filter operating in the mid-wave infrared(MWIR)spectrum.The filter is designed with a single layer of slab waveguide decorated with a layer of gold grating arrays.Thi...This work proposes a novel design for a narrowband filter operating in the mid-wave infrared(MWIR)spectrum.The filter is designed with a single layer of slab waveguide decorated with a layer of gold grating arrays.This design demonstrates superior narrowband transmission properties within the MWIR range,which can be explained in the framework of guided-mode resonance(GMR).Since MWIR spectral data is crucial for identifying the chemical fingerprint of man-made objects and natural materials,the GMR filters hold great potential in integration with commercial MWIR photodetectors and focal plane arrays(FPAs)and addressing the market’s demand for ultra-compact spectral detection solutions.Theoretical studies have investigated the influential parameters in the GMR filter design and provided the methods towards optimal filtering performance.The center wavelength of these transmission filters exhibits significant tunability,spanning from 3μm to 5μm across the MWIR spectrum,while the full width at half maximum(FWHM)exhibits remarkable variability,ranging from 5.7 nm to 101.0 nm,enabling the attainment of desired filter performance contingent upon judicious waveguide material selection and optimized structural design.This work forges a path toward integrating multifunctional capabilities into ultra-compact MWIR sensors.展开更多
Semitransparent organic solar cells(ST-OSCs)are promising for building-integrated photovoltaics,offering power generation,transparency and heat insulation.High performance ST-OSCs need sophisticated optical management...Semitransparent organic solar cells(ST-OSCs)are promising for building-integrated photovoltaics,offering power generation,transparency and heat insulation.High performance ST-OSCs need sophisticated optical management to balance the competing demands of power conversion efficiency(PCE)and average visible transmittance(AVT)for various applications.Here,a type of aperiodic band-pass filter(ABPF)made from LiF and ZnS are developed to selectively alter visible light transmission and near-infrared(NIR)reflection.This ABPF allows the active layers of ST-OSCs to re-harvest unabsorbed NIR photons,compensating for the loss of photocurrent caused by the high AVT of ST-OSCs.By carefully adjusting the thicknesses of individual layers within ABPFs,we can modulate their photonic bandgaps,enabling ST-OSCs to achieve multifunctional performance.ST-OSCs combined with the ABPF-1 demonstrate a remarkable light utilization efficiency(LUE)of 5.40%,a PCE of 14.21%and an AVT of 38.0%,which represent some of the highest values reported for ST-OSCs.Moreover,the ST-OSCs are equipped with excellent color neutrality and heat insulation functions.The ST-OSCs employing ABPF-2 exhibit a LUE of 4.78%,a color rendering index of 87.5 and an infrared rejection rate of 91.6%.This work offers an effective method for employing ABPFs in the creation of high-performance multifunctional ST-OSCs.展开更多
基金supported by Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515110824 and 2025A1515011839)Shenzhen Science and Technology Program(No.RCBS20231211090638066).
摘要Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-ments in karst hydrology,significant gaps remain in long-term trends,underlying processes,and quantitative effects of environmental changes.This is especially true in areas like the Wujiang River(WJ)in China,where human activities such as reservoir construction and land use/cover changes have accelerated hydrochemical changes.We combined recent and historical monitoring data to provide a detailed analysis of the spatial and temporal characteristics,evolution,and controlling factors of major ions in WJ.These findings are important for local water management and contribute to global efforts to manage similar karst systems facing human-induced pressures.Our research shows clear seasonal differences in solute concentrations,with higher levels during the dry season.WJ’s water is rich in calcium,with Ca-HCO3 ion pairs being the most common.Reservoir monitor-ing stations show much higher levels of NO3−and SO42−compared to river-type stations,likely due to longer hydraulic retention time and increased acid deposition.The study confirms the significant role of pH and water temperature in rock weathering processes.Land use/cover changes were identified as the primary drivers of solute variations(46.37%),followed by lithology(13.92%)and temperature(8.35%).Over the past two decades,in-tense carbonate weathering has been observed,especially during wet seasons.Among karstic provinces,Guizhou Province stands out with the highest ion concentrations,indicative of its extensive karst coverage and heightened weathering processes.
基金funded by the National Natural Science Foundation of China(Grant No.:62276040,62331008,62221005,62576064)National Key Research and Development Program of China(Grant No.:2024YFB4710100)+3 种基金National Natural Science Foundation of Chongqing(Grant No.:CSTB2022NSCQ-MSX0436)Key Projects in Technological Innovation and Application Development of Chongqing Municipality(Grant No.:CSTB-2024TIAD-KPX0040,CSTB2025TIADKPX0009)Chongqing Natural Science Foundation for Innovative Development Joint Fund(Grant No.:CSTB2023NSCQ-LZX0047,CSTB2025NSCQ-LZX0147)Chongqing Key Laboratory for Precise Diagnosis and Treatment of Kidney Diseases.
摘要With the rapid development of artificial intelligence(AI)and multimodal imaging technology,intelligent surgical navigation systems have become a research hotspot in the field of precision tumor treatment.Due to clinical characteristics of tumor surgery—such as blurred lesion boundaries,complex anatomical structures,and high requirements for functional preservation—there are higher demands for precision,real-time performance,and adaptability of surgical navigation.This article analyzes the current development status of tumor surgery navigation platforms both in China and internationally,outlines the core components of intelligent surgical navigation systems,delves into the key technical issues in the application of existing surgery navigation systems in tumor treatment and the driving role of AI technology,discusses the urgent problems to be solved in tumor surgical navigation systems,and provides an outlook on the technological development trends of intelligent tumor surgery navigation systems.
基金supported by the operating fund of Key Laboratory of Nuclear Power Systems and Equipment(Shanghai Jiao Tong University),Ministry of Education,China,the Natural Science Foundation of Shanghai Municipality(25ZR1402177)the National Natural Science Foundation of China(12105167)。
摘要Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions.
基金supported in part by the National Natural Science Foundation of China under Grant U22A2004in part by Zhejiang Key Laboratory of Digital Fashion and Data Governance,Zhejiang Sci-Tech University,Hangzhou,China.
摘要The rapid growth of networked systems and the increasing diversity of cyberattack behaviors have posed significant challenges to intrusion detection,particularly in scenarios characterized by high-dimensional features and severe class imbalance.Conventional detection approaches based on handcrafted rules or shallow representations often exhibit limited robustness under such conditions.To address these issues,this paper presents a hybrid deep learning framework for network intrusion detection that integrates complementary feature learning mechanisms within a dual-branch architecture.Specifically,a Transformer branch is employed to model long-range temporal dependencies in network traffic,while a convolutional neural network branch(CNN)is used to capture localized and fine-grained feature patterns.An attention-based fusion strategy is further introduced to adaptively aggregate branch-specific representations and enhance intrusion-sensitive features.In addition,an autoencoder-based feature reconstruction module is incorporated before the dual-branch network to compress and reconstruct input features through an encoder-decoder structure,thereby preserving essential behavioral characteristics of network traffic and improving feature discriminability.To mitigate the impact of class imbalance,a Dynamic Weighted Logit-adjusted Focal Loss(DWLF)is introduced to reduce the bias toward majority classes during model optimization.Extensive experiments conducted on two public benchmark datasets demonstrate the effectiveness of the proposed approach.The proposed model achieves an overall accuracy of 90.01%on the UNSW-NB15 dataset and 97.82%on the NF-CSE-CIC-IDS2018 dataset.Experimental results indicate improved robustness under highly imbalanced data distributions,demonstrating stable performance across datasets with different traffic characteristics.
基金National Key Research and Development Program of China,Grant/Award Numbers:2022YFC2203902,2024YFE0211900Natural Science Foundation of Chongqing,China,Grant/Award Number:CSTB2023NSCQLZX0087。
摘要Highly responsive near-infrared(NIR)photodetectors(PDs)are increasingly required for advanced photoelectric systems.While silicon-based detectors benefit from mature fabrication and CMOS compatibility,their performance is limited by the intrinsic bandgap of 1.12 eV,which leads to weak responsivity in the NIR band.Herein,a high-responsivity silicon-based NIR PD is proposed by incorporating a heterostructure of black silicon(B-Si)and PtTe2.The B-Si integrated in the photosensitive region of a Si p-i-n diode introduces sub-bandgap defect states,significantly enhancing NIR absorption.Further,the PtTe2film coated onto the B-Si surface induces energy band bending and enhances the interfacial electric field,which together promote the separation and collection of photogenerated carriers.Additionally,the PtTe2film forms a passivation layer on the B-Si surface,which repairs surface defects and suppresses carrier recombination,thereby reducing the dark current of the device.The PtTe2/B-Si PD demonstrates remarkable NIR detection performance,achieving a responsivity of 0.64 A W–1at 1064 nm and showing a 146%improvement over conventional silicon photodiodes,while maintaining excellent detectivity(D*)of 3.54×1011Jones.This performance underscores the device's capability for weak-light detection and positions it as a viable candidate for CMOS-integrated NIR photonics.
摘要BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are unclear.AIM To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric hospital.METHODS We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan’s Youfu Hospital.RESULTS Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison group.The overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were male.The most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for COVID-19.SCZ patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between individuals.CONCLUSION Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.
基金supported by National Natural Science Foundation of China(82325012)General project of State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration(2024MS05).
摘要Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D printing,and numerical control machining are reshaping the workflow of complete denture restoration.Unlike conventional methods that rely heavily on clinical experience and manual techniques,digital technologies offer greater precision,predictability,and efficacy.They also streamline the process by reducing the number of patient visits and improving overall comfort.Despite these improvements,the clinical application of digital complete denture restoration still faces challenges that require further standardization.The major issues include appropriate case selection,establishing consistent digital workflows,and evaluating long-term outcomes.To address these challenges and provide clinical guidance for practitioners,this expert consensus outlines the principles,advantages,and limitations of digital complete denture technology.The aim of this review was to offer practical recommendations on indications,clinical procedures and precautions,evaluation metrics,and outcome assessment to support digital restoration of complete denture in clinical practice.
基金supported by the National Natural Science Foundation of China,Nos.82071307(to HL),82271362(to HL),82171294(to JW),82371303(to JW),and 82301460(to PX)the Natural Science Foundation of Jiangsu Province,No.BK20211552(to HL)+1 种基金Suzhou Medical Technology Innovation Project-Clinical Frontier,No.SKY2022002(to ZY)the Science and Education Foundation for Health of Suzhou for Youth,No.KJXW2023001(to XL)。
摘要Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.Ferroptosis is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic stroke.However,there are few studies on oligodendrocyte progenitor cell ferroptosis.We analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral ischemia.Bioinformatics analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ferroptosis.PLIN2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet accumulation.For further investigation,we established a mouse model of cerebral ischemiaeperfusion.We found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct area.The ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin injury.We also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor cells.Plin2 knockdown rescued demyelination and improved neurological deficits.Our findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.
基金supported by the National Natural Science Foundation of China(Nos.22273098,22373003,22103002 and 52033001)the Key Project of Anhui Province Science and Technology Innovation Platform(No.202305a12020030)the financial support from the Anhui Provincial Natural Science Foundation(No.2408085Y004)。
摘要Polymeric materials which can undergo controlled degradation and recycling are of great significance for a sustainable society.Although tremendous progress has been made in the degradation and recycling of both thermoplastic and thermoset plastics,the development of high-performance degradable polymer adhesives is rare.Here,we have prepared high-performance nucleobase-containing thioctic acid-based supramolecular polymer adhesives through free radical polymerization.The specific hydrogen-bonding interactions between complementary nucleobases greatly improve the weak cohesion of the thioctic acid-based polymers and enhance the environmental stability of the thioctic acidbased polymers simultaneously.Degradation of the nucleobase-containing thioctic acid-based supramolecular polymers is achieved by the reduction of the disulfide backbone,and the cycle of degradation and repolymerization is further achieved via oxidative polymerization.The adhesion strength of the nucleobase-containing thioctic acid-based supramolecular polymers after two cycles of degradation and repolymerization still reaches as high as 4.7±0.3 MPa.This work provides an approach for the development of environmentally stable and high-performance degradable thioctic acid-based adhesives.
基金supported by the National Key Research and Devel-opment Program of China(2022YFA1004600)the National Nat-ural Science Foundation of China(62192750,62192752,62373294,624B2111).
摘要Cyber-physical system(CPS)is a networked,intelligent system that tightly integrates physical systems with cutting-edge information technologies to achieve efficient and secure operations.It is widely regarded as a cor-nerstone of the Fourth Industrial Revolution.The global energy industry is undergoing a period of profound change marked by large-scale integration of renewable energy,multi-energy synergy,and the proliferation of distributed energy resources,which in turn heightens energy system complexity and uncertainty,creating sig-nificant challenges for system design and operation.Cyber-physical energy system(CPES)-a CPS tailored to the energy sector-provides a digital-physical infrastructure for efficient,secure production and consumption of energy under uncertainty,which offers a comprehensive solution for system design and operation.This pa-per presents a conceptual framework for CPES,outlines the typical structure and design/operation paradigms,and reports on an operational pilot implementation project.It further identifies key challenges in modeling and design,scheduling,control,as well as safety and security as priorities for future research.
基金financially supported by the National Natural Science Foundation of China(Grant 22278439,21776313)the Shandong Province Higher Education Youth Innovation Technology Support Program(Grant 2022KJ074)。
摘要Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H*migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C8-C14branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.
基金support from the National Natural Science Foundation of China(Nos.52373176,52073067)。
摘要Benzotriazole(BTA)-based A2-A_1-D-A_1-A2type wide-bandgap(WBG)non-fullerene acceptors(NFAs)have shown promising potential in indoor photovoltaic,and in-depth investigation of their structure-property relationship is of great significance.Herein,we explored the chlorination effect of the side chain on the terminals.We introduced Cl atoms into the benzyl side chains in parent BTA5 to synthesize two NFAs,BTA5-Cl with mono-chlorinated benzyl groups and BTA5-2Cl containing bi-chlorinated benzyl groups.We chose D18-Cl with deep-energy levels and strong crystallinity to pair with these three acceptors,affording high photovoltage and photocurrent.With the stepwise chlorination,the open-circuit voltage(VOC)values decrease from 1.28,1.22,to 1.20 V,while the corresponding power conversion efficiencies(PCEs)improve from 5.07%,9.15%,to 10.96%.Compared with BTA5-based OSCs,introducing Cl atoms downshifts the energy levels and slightly increases the non-radiative energy loss(0.14<0.17<0.19 e V),resulting in a sequential decrease in VO C.However,more chlorine atom replacements produce more effective exciton dissociation,higher charge transfer,and balanced carrier mobility in the blend films,ultimately achieving better PCEs.This work indicates that chlorination of the benzyl group on the terminals can improve the device's performance,implying good application potential in indoor photovoltaics.
基金supported by 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC21048)Foundation of Sichuan Provincial Science and Technology Program(2022JDR0091,2023NSFSC0004,2023NSFSC0639,2023NSFSC1742)+5 种基金Cooperation Project for Academician&Expert Workstation(HXYS20001)Sichuan University Education Foundation(0040206107011)National Natural Science Foundation of China(Nos.82371883,82402191)China Postdoctoral Science Foundation(2023M732456)Postdoctor Research Fund of West China Hospital(2024HXBH142)Sichuan University“From 0 to 1”Innovation Research Project(2023SCUH0056).
摘要Objectives:Recently,pre-/post-operative Local Estrogen Therapy(LET)has shown effectiveness in alleviating Pelvic Organ Prolapse(POP)symptoms in clinical therapy.However,there is a lack of scientific evidence to support these claims.Therefore,we aimed to explore the anti-senescence effects and mechanisms of 17β-estradiol(E2)on POP-derived fibroblasts.Methods:The primary fibroblast cells were isolated and cultured fromthe surgical samples of postmenopausal women clinically diagnosed with pelvic organ prolapse(POP)at stages III-IV(quantified using the POP-Q system)and without any other treatment within 6 months.(n=12,age 50–75).Colorimetric Cell Counting Kit(CCK-8)assay and Senescence-Associated-β-Galactosidase(SA-β-Gal)staining were used to test the cell proliferative capacity and the senescence rate.Western blotting(WB)was used to detect the expression of Collagen Type I(COL-I),Collagen Type III(COL-III),Cyclin-dependent kinase 4 inhibitor A(p16INK4a),Cyclin-dependent kinase inhibitor 1A(p21),Tumor Protein 53(p53),Sirtuin 1(SIRT-1)and Microtubule-associated protein 1A/1B-light chain 3-I/II(LC3-I/II)protein.A transmission ElectronMicroscope(TEM)was used to observe the ultrastructure of fibroblasts.Results:The results showed that E2 significantly promoted the proliferation of fibroblasts derived from POP and reduced the staining rate of SA-β-Gal.It markedly enhanced the extracellular matrix proteins COL-I and COL-III,accompanied by inhibition of the senescent maker p16INK4a.Additionally,our results improved the cells’autophagy and metabolic activity.Additionally,our results indicate the anti-senescence mechanism of E2 through the mediated SIRT-1/p53/p21 axis pathway.Conclusion:We provide preliminary evidence for the anti-aging effects and mechanisms of E2 on POP,hoping to provide a theoretical basis for estrogen against POP senescence and guide the clinical application and local administration of estrogen in POP treatment.
基金supported by the National Key Research and Development Program of China under Grant No.2019YFB2203400the National Natural Science Foundation of China under Grant No.61974014.
摘要This work proposes a novel design for a narrowband filter operating in the mid-wave infrared(MWIR)spectrum.The filter is designed with a single layer of slab waveguide decorated with a layer of gold grating arrays.This design demonstrates superior narrowband transmission properties within the MWIR range,which can be explained in the framework of guided-mode resonance(GMR).Since MWIR spectral data is crucial for identifying the chemical fingerprint of man-made objects and natural materials,the GMR filters hold great potential in integration with commercial MWIR photodetectors and focal plane arrays(FPAs)and addressing the market’s demand for ultra-compact spectral detection solutions.Theoretical studies have investigated the influential parameters in the GMR filter design and provided the methods towards optimal filtering performance.The center wavelength of these transmission filters exhibits significant tunability,spanning from 3μm to 5μm across the MWIR spectrum,while the full width at half maximum(FWHM)exhibits remarkable variability,ranging from 5.7 nm to 101.0 nm,enabling the attainment of desired filter performance contingent upon judicious waveguide material selection and optimized structural design.This work forges a path toward integrating multifunctional capabilities into ultra-compact MWIR sensors.
基金the financial support provided by the National Natural Science Foundation of China(22361132545,52273200,52473199)the Science and Technology Development Program of Jilin Province(20230101131JC)+1 种基金RSCF Grant(24-4300178)Ministry of Science and Higher Education of the Russian Federation(Contract No.075-00276-25-00)。
摘要Semitransparent organic solar cells(ST-OSCs)are promising for building-integrated photovoltaics,offering power generation,transparency and heat insulation.High performance ST-OSCs need sophisticated optical management to balance the competing demands of power conversion efficiency(PCE)and average visible transmittance(AVT)for various applications.Here,a type of aperiodic band-pass filter(ABPF)made from LiF and ZnS are developed to selectively alter visible light transmission and near-infrared(NIR)reflection.This ABPF allows the active layers of ST-OSCs to re-harvest unabsorbed NIR photons,compensating for the loss of photocurrent caused by the high AVT of ST-OSCs.By carefully adjusting the thicknesses of individual layers within ABPFs,we can modulate their photonic bandgaps,enabling ST-OSCs to achieve multifunctional performance.ST-OSCs combined with the ABPF-1 demonstrate a remarkable light utilization efficiency(LUE)of 5.40%,a PCE of 14.21%and an AVT of 38.0%,which represent some of the highest values reported for ST-OSCs.Moreover,the ST-OSCs are equipped with excellent color neutrality and heat insulation functions.The ST-OSCs employing ABPF-2 exhibit a LUE of 4.78%,a color rendering index of 87.5 and an infrared rejection rate of 91.6%.This work offers an effective method for employing ABPFs in the creation of high-performance multifunctional ST-OSCs.