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Prevalence and clinical characteristics of diabetic retinopathy in patients newly diagnosed with ketosis-onset diabetes:A real-world study 认领 引用 被引量：1
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作者 Man-Rong Xu Meng-Han Li +4 位作者 Jun-Wei Wang Ya-Wen Zhang Jun-Xi Lu Jiang-Feng Ke Lian-Xi Li 《World Journal of Diabetes》 SCIE 2026年第3期127-138,共12页
BACKGROUND The classification of ketosis-onset diabetes is controversial,and the prevalence and clinical characteristics of diabetic retinopathy(DR)in ketosis-onset diabetes mellitus remain unclear.AIM To compare the ... BACKGROUND The classification of ketosis-onset diabetes is controversial,and the prevalence and clinical characteristics of diabetic retinopathy(DR)in ketosis-onset diabetes mellitus remain unclear.AIM To compare the prevalence and risk factors of DR among patients with type 1 diabetes mellitus(T1DM),ketosis-onset diabetes,and non-ketotic type 2 diabetes mellitus(T2DM).METHODS This real-world observational study enrolled 1777 patients with newly diagnosed diabetes between January 2003 and December 2012,including 211 with T1DM,673 with ketosis-onset diabetes,and 893 with non-ketotic T2DM.DR was assessed using digital nonmydriatic fundus photography,and its severity was graded based on the ETDRS classification.Clinical characteristics and risk factors of DR were compared across the three groups.RESULTS After controlling for age and sex,DR prevalence was significantly higher in ketosis-onset diabetes(9.5%)than in T1DM(5.7%,P=0.034),but not significantly different from non-ketotic T2DM(12.3%,P=0.105).Risk factors for DR in ketosis-onset diabetes and non-ketotic T2DM included increased estimated glomerular filtration rate(eGFR)and urinary albumin excretion.In contrast,elevated eGFR and 2-hour postprandial C-peptide were independent risk factors for DR in T1DM.The prevalence and risk factors for DR in ketosis-onset diabetes were similar to those in non-ketotic T2DM,but differed from T1DM.CONCLUSION These findings further support classifying ketosis-onset diabetes as a subtype of T2DM rather than idiopathic T1DM.However,the distinctive clinical features of ketosis-onset diabetes should not be ignored. 展开更多
关键词 Diabetic classification Ketosis-onset diabetes Diabetic retinopathy Type 1 diabetes Type 2 diabetes
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