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Honghua Ruyi Pill,a compound herbal medicine,improves endometriosis-related dysmenorrhea:A multicenter randomized,double-blind,placebo-controlled trial 认领 引用
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作者 Mei Han Xue-fang Liang +7 位作者 Jing Gao Yan Wang Li-xing Cao Bao-jin Wang Yue Wang Zerang Zhuoma Jian-ping Liu Hui-lan Du 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第2期182-191,共10页
Background:Endometriosis is an estrogen-dependent,progesterone-resistant gynecological disorder,with dysmenorrhea being the most common manifestation.Objective:This study evaluates the efficacy and safety of the Tibet... Background:Endometriosis is an estrogen-dependent,progesterone-resistant gynecological disorder,with dysmenorrhea being the most common manifestation.Objective:This study evaluates the efficacy and safety of the Tibetan herbal medication Honghua Ruyi Pill(HHRY)in managing endometriosis-related dysmenorrhea.Design,setting,participants and interventions:This is a multi-center,randomized,placebo-controlled,double-blinded clinical trial conducted in seven hospitals in China from July 2021 to January 2023.A total of 164 patients with endometriosis and moderate or severe dysmenorrhea(visual analog scale[VAS]score≥4)were assigned to the treatment or placebo group in a 1:1 ratio by block randomization.Patients received HHRY or placebo twice a day for three consecutive menstrual cycles(MCs)and were followed up for three MCs after stopping the medication.Main outcome measures:Primary outcomes were VAS score of the maximum(VASmax)of dysmenorrhea,endometriosis health profile-5(EHP-5)score,and 5-level EuroQoL 5-dimension version(EQ-5D-5L)score.Secondary outcomes were VASmaxof non-menstrual pelvic pain,days of leave taken,emergent use of nonsteroidal anti-inflammatory drugs(NSAIDs)and changes in uterine,cyst and nodule sizes.Safety profiles were assessed based on adverse events,vital signs,serology markers,urinalysis,and liver and kidney function indicators.Results:VASmaxof dysmenorrhea,EHP-5 score,EQ-5D-5 L score,and VASmaxof non-menstrual pelvic pain were significantly lower in the HHRY group compared to the placebo group at the final follow-up(3.00 vs 5.50,P0.999),but the number of patients who had taken time off was significantly different(5.00 vs 14.00,P=0.028).Sonographic evaluations indicated no significant change in uterine size(P=0.183)but showed a significant reduction in cyst size(2.09 cm vs 0.20 cm,P=0.027,sum of 3 diameters of cysts)and nodule size(0.70 cm vs 0.00 cm,P<0.001,maximum nodule diameter).Safety analysis showed no significant difference in the incidence of adverse events between groups(18.85%vs 28.05%,P=0.059).Conclusion:HHRY can improve dysmenorrhea,chronic pelvic pain,and quality of life in patients with endometriosis.It has a good overall safety profile,and a 3-month treatment can maintain its effects for at least 3 months after the last dose.HHRY may be considered as a new therapeutic option for treating endometriosis-related dysmenorrhea. 展开更多
关键词 Honghua Ruyi Pill Herbal medicine Endometriosis Dysmenorrhea Quality of life Non-menstrual pelvic pain
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Transparent UV-cured Phosphorus/Nitrogen Hybrid Coating for Simultaneously Enhancing Flame Retardancy and Surface Hardness of Polycarbonate 认领 引用
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作者 Jing Gao Liang Chen +6 位作者 Liang-Yuan Qi Su-Hong Li Yuan Hu Xin Wang Lian-Min Ji Ying-Jian Wang Wei-Yi Xing 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第8期2670-2680,I0017,共11页
The flame-retardant monomer PG(P)was synthesized from diethylphosphinic acid and glycidyl methacrylate(GMA).Simultaneously,the phosphorus-containing flame-retardant monomer,TAEP(T),was synthesized from phosphorus oxyc... The flame-retardant monomer PG(P)was synthesized from diethylphosphinic acid and glycidyl methacrylate(GMA).Simultaneously,the phosphorus-containing flame-retardant monomer,TAEP(T),was synthesized from phosphorus oxychloride and 2-hydroxyethyl acrylate.A 50μm thick transparent UV-cured coating,designated MAAR-P8T4,was successfully constructed on 0.5 mm thick polycarbonate(PC)films by blending PG and TAEP with melamine acrylate resin(MAAR).The fabricated coating demonstrated a high transmittance of 91.9%in the visible-light spectrum.The incorporation of monofunctional PG effectively regulated the system viscosity and mitigated curing shrinkage stress.Furthermore,the synergistic action of phosphorus in different valence states and nitrogen from MAAR imparted a dual gas-phase-condensed phase flameretardant mechanism to the coating,enabling the PC substrate to attain a V-0 rating in the UL-94 vertical burning test.This research indicates that the MAAR-P8T4 coating engineered via molecular design and component optimization concurrently overcomes the limitations of PC,namely its low surface hardness and inherent flammability.A straightforward and efficient preparation strategy provides a practical approach for transparent flame-retardant coatings for electronic and electrical applications. 展开更多
关键词 Synergistic flame retardant system UV-curable coatings Transparent coating Flame retardancy Polycarbonate
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Hotspots of disagreement across global urban land projections until 2100 认领 引用
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作者 Jasper van Vliet Hang Yang +9 位作者 Nathalie Benz Changxiu Cheng Jonathan Doelman Jing Gao Qingxu Huang Eric Koomen Xuecao Li Lu Niu Elizabeth A.Schrammeijer Yuyu Zhou 《Geography and Sustainability》 CSCD 2026年第1期155-165,共11页
Projections of future urban land change are essential for a range of sustainability assessments,including those related to biodiversity loss,carbon emissions,and agricultural land conversion.However,to what extent and... Projections of future urban land change are essential for a range of sustainability assessments,including those related to biodiversity loss,carbon emissions,and agricultural land conversion.However,to what extent and where current projections agree or disagree remains unknown.Here,we systematically compare existing global projections that are consistent with the Shared Socioeconomic Pathways.We find that the total global urban land area is expected to increase by 112%between 2020 and 2100(averaged across all projections),with a coefficient of variation of 0.81.This variation is mostly caused by the selection of the underlying drivers that are included in the different models.Regionally,the highest average growth rates are found in sub-Saharan Africa(+679%to+730%),while this region also has the highest variation across projections(coefficient of variation ranging from 2.02 to 2.18).When ranking scenarios within a study from the highest to the lowest projected increase in urban land,rankings are relatively similar for regions in the Global North,but not for regions in the Global South.The large disagreement across projections can lead to high uncertainties in assessments of future urban land change impacts,which can undermine the effectiveness of long-term planning,policymaking,and resource management decisions. 展开更多
关键词 Global Urban Built-up Projections SSPs Model comparison
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Multi-View Deep Fuzzy Clustering for Data Representation Learning 认领 引用
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作者 Jianing Zhang Zhikui Chen +1 位作者 Jing Gao Peng Li 《Computers, Materials & Continua》 SCIE EI 2026年第7期799-818,共20页
With the increasing development of ocean information technology,the multi-view fuzzy clustering is attracting increasing attention in pattern mining for massive multi-view ocean data of heterogeneous distributions,owi... With the increasing development of ocean information technology,the multi-view fuzzy clustering is attracting increasing attention in pattern mining for massive multi-view ocean data of heterogeneous distributions,owing to its superior performance.However,the previous multi-view fuzzy clustering methods cannot fully consider informative topologies hidden in data distributions,which are crucial to recognize partitions of data.Moreover,they fail to capture invariant structures of multi-view ocean data in learning clustering-specific fusion representation.In addition,they do not take into consideration consistencies contained in the manifolds of data generation in mining soft patterns.To address those challenges,the deep multi-view generative fuzzy contrastive clustering(DMGFCC)is proposed within a Siamese architecture,which captures soft patterns of data via clustering-specific fusion representations of invariant structures in informative topologies.To be specific,a multi-view Siamese generative adversarial architecture is designed to capture the joint distribution of data as well as invariant structures,which is composed of the view-specific generator network providing pairwise implicit constraints,the view-specific discriminator network distilling knowledge of real data,and the view-specific cluster network capturing fuzzy patterns of fusion information.Furthermore,a generative adversarial dual contrastive clustering loss is devised,which consists of a generative adversarial loss fitting data distributions and a dual contrastive clustering loss learning soft patterns with consistencies of data manifolds.Finally,extensive experiments are conducted on four benchmark datasets,and the results demonstrate the competitive performance compared with the 11 representative methods. 展开更多
关键词 Neural networks fuzzy systems pattern mining multi-view feature fusion
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Delayed photosynthesis response causes carbon assimilation reduction in soybean under fluctuating light 认领 引用
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作者 Jing Gao Shenglan Li +7 位作者 Yi Lei Qi Wang Zili Ning Zhaohong Lu Xianming Tan Mei Xu Feng Yang Wenyu Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期648-658,共11页
Plants encounter dynamic light environments in natural field conditions,and species differ in their physiological and biochemical mechanisms for acclimating to fluctuating light(FL).The manner in which soybean(Glycine... Plants encounter dynamic light environments in natural field conditions,and species differ in their physiological and biochemical mechanisms for acclimating to fluctuating light(FL).The manner in which soybean(Glycine max(L.) Merr.) coordinates multiple physiological adjustments to FL remains poorly understood.This study assessed the effects of FL on soybean morphology and photosynthetic traits by examining changes in photosynthetic gas exchange parameters and chlorophyll(Chl) a fluorescence under alternating high-and low-light conditions.Results indicated that soybeans exposed to FL exhibited reduced dry matter accumulation,smaller and thinner leaves,and a lower Chl a/Chl b levels-characteristics typically associated with plants grown under continuous low-light.Despite these morphological similarities,their photosynthetic gas exchange rates and photosynthetic capacity were maintained at levels comparable to those under steady high light,unlike plants grown under constant low-light.Thus,acclimation to FL is distinct from adaptation to sustained low-light conditions.Correlation analyses revealed that the decline in carbon assimilation under FL primarily stemmed from two factors:the slow recovery of stomatal conductance upon transition to high light and the delayed relaxation of nonphotochemical quenching when light intensity decreased.Therefore,the reduction in carbon assimilation under FL cannot be attributed to low-light phase adjustments but rather reflects a lag in photosynthetic responsiveness to changing light conditions. 展开更多
关键词 soybean fluctuating light CO2assimilation dynamic photosynthesis photosynthetic limitation stomatal opening non-photochemical quenching
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Effect of preferential CeOx loading on monolithic WO3/CeO2-TiO2 catalysts for NH3-SCR of NOx removal 认领 引用
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作者 Jing Gao Mingyu Guo +6 位作者 Guang Yang Shaoping Cui Yingjie Zhao Boqun Liu Meng Xiao Ke Niu Sainan Zhou 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第5期1523-1532,共10页
The most effective technology used for NOx removal is selective catalytic reduction with ammonia(NH3-SCR).In contrast to the conventional V2O5-WO3/TiO2 catalyst,cerium-tungsten-titanium oxides catalysts we... The most effective technology used for NOx removal is selective catalytic reduction with ammonia(NH3-SCR).In contrast to the conventional V2O5-WO3/TiO2 catalyst,cerium-tungsten-titanium oxides catalysts were prepared,which significantly broaden the SCR activity window while avoiding the vanadium biotoxicity.The monolithic WO3/CeO2-TiO2-CC catalyst with over 85%NOx conversion in the 275-475℃ range is found by changing the loading sequence of CeO2 and WO3.And it exhibits excellent H2O resistance,maintaining 90%NOx conversion at 325℃.The preferential loading of the redox CeO2 boosts the increase of the surface adsorbed oxygen content and Ce3+ratio.Meanwhile,WO3/CeO2-TiO2-CC exhibits excellent acidity,which facilitates the NH3 adsorption.In situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTs)experiments demonstrate that changing the loading sequence of the active components affects the rate of Lewis acid sites consumption and SCR reaction.The negative effect of SO2+O2 adsorption on the catalysts is also demonstrated.SO2 is more likely to be oxidized to SO3 on the CeO2/WO3-TiO2-CC and WO3/CeO2-TiO2-CC,resulting in the formation of metal sulphates and decreasing the catalytic performance.SOx affects the L-H pathway on the three catalysts(CeO2/WO3-TiO2-CC,WO3/CeO2-TiO2-CC and CeO2-WO3/TiO2-CC),and affects the E-R pathway on the WO3/CeO2-TiO2-CC catalyst.Above results indicate that adjusting the binding sequence of CeO2 and WO3 with TiO2 changes the catalysts'redox and acidic properties. 展开更多
关键词 NOₓconversion NH3-SCR WO3/CeO2-TiO2-CC catalyst CeO2 Mechanism Rare earths
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Cation‑Disordered Rock‑Salt Lithium Titanium Oxyfluoride Anode Enabling High‑Rate Li‑Ion Storage Through a 3D Percolation Network 认领 引用
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作者 Jing Gao Minghao Hua +9 位作者 Junze Lu Yuying Qin Shuxian Zhang Qingyu Li Lidong Yang Chengxiang Wang Xiaohang Lin Yuanwei Sun Longwei Yin Rutao Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第8期603-620,共18页
Pseudocapacitive materials employ rapid,non-diffusion-limited faradaic processes to store charge,demonstrating significant potential for fast-charging batteries and supercapacitors.However,the high redox potentials of... Pseudocapacitive materials employ rapid,non-diffusion-limited faradaic processes to store charge,demonstrating significant potential for fast-charging batteries and supercapacitors.However,the high redox potentials of existing pseudocapacitive anodes substantially lower the overall cell voltage and energy density.Here,a cation-disordered rock-salt lithium titanium oxyfluoride(DRX-LixTiOF2,0<x<2)is reported to reversibly accommodate approximately 1.19 mol of Li+(~310 mAh g−1)and delivers high-rate performance(exceeding 64.4 C)via pseudocapacitive Li+storage within a low potential window extending down to 0.1 V vs.Li+/Li.This pseudocapacitive behavior is characterized by several structural and electrochemical features:the absence of phase transformation during Li+intercalation,quasi-rectangular cyclic voltammetry curves,sloping charge/discharge profiles and a surface-controlled current response.We further reveal that the pseudocapacitive characteristics originate from a three-dimensional percolation network that facilitates fast Li+migration with low energy barriers,enabled by a cation/anion-disordered structure arising from the mixed occupancy of Li/Ti cations and O/F anions.Owing to its low operating potential and high-rate capability,DRX-LixTiOF2 allows a lithium-ion capacitor to attain 4.0 V cell voltage and achieve energy and power densities several times higher than those obtained with conventional anodes,such as battery-type Li4Ti5O12 or pseudocapacitive materials like Nb2O5 and TiO2. 展开更多
关键词 Disordered rock-salt materials Pseudocapacitance Three-dimensional Li+percolation network Anode materials Lithiumion capacitors
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Facile Synthesis of an Injectable Redox/pH Dual Stimuli-responsive Hydrogel System for Drug Release 认领 引用
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作者 Ning Duan Xin-Ran Luo +7 位作者 Yan-Di Zhou Jun-Yu Chai Ji-Zhen Wang Jing Gao Hui-Fang Ye Su-Yan Shan Yong Liu Chang-Chun Yu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第4期1114-1125,I0017,共12页
Multiresponsive hydrogels,capable of responding to more than one external stimulus,have demonstrated great utility in biomedical applications.This study presents a facile method for preparing an injectable,dual redox/... Multiresponsive hydrogels,capable of responding to more than one external stimulus,have demonstrated great utility in biomedical applications.This study presents a facile method for preparing an injectable,dual redox/p H-responsive hydrogel system based on poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)(PEDOT:PSS)for the controlled delivery of pharmacologically active bevacizumab(BEV).The hydrogel system was fabricated via a one-step physical crosslinking process by mixing PEDOT:PSS with BEV,leveraging electrostatic interactions,hydrogen bonding,and ionic crosslinking.The resulting PEDOT@BEV system exhibited a homogeneously porous structure,robust mechanical stability,and good biocompatibility.Under acidic(p H=5)or alkaline(p H=10)conditions,especially when coupled with elevated reactive oxygen species(ROS)levels,the as-prepared PEDOT@BEV achieved rapid BEV release.This may be attributed to PEDOT oxidation and charge repulsion.In contrast,BEV release remained stable under physiological conditions(p H=7.4,0 mmol/L H2O2).In vitro results supported that the resulting PEDOT@BEV demonstrated potent anti-angiogenic efficacy,significantly inhibiting cellular migration and tube formation of human retinal vascular endothelial cells(HRVECs).The vascular endothelial growth factor expression was further reduced.In a mouse model of corneal neovascularization,the PEDOT@BEV system enabled the continuous controlled release of BEV for over 14 days.It exhibited superior anti-angiogenic efficacy compared to free BEV treatment,more effectively reducing neovascularization and corneal inflammation.The designed platform in this work demonstrated versatility by successfully incorporating other therapeutic antibodies(e.g.,rituximab,trastuzumab),highlighting its potential for tailored drug delivery in oncology and neovascular diseases.The outcome of this study offers a promising strategy for spatiotemporally controlled drug release in response to specific microenvironmental cues. 展开更多
关键词 Dual-responsive hydrogel PEDOT:PSS Bevacizumab Anti-angiogenesis Controlled drug delivery
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A Comprehensive Review of Complex Logical Reasoning in Large Vision-Language Models 认领 引用
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作者 Weiqiang Jin Yang Liu +9 位作者 Yang Gao Shixiang Tang Yanghao Zhou Jinhu Qi Wentao Zhang Junli Wang Jing Gao Yue Ma Ziwei Zhang Biao Zhao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第7期1-51,共51页
relational reasoning,and cross-modal evidence integration.Reasoning abilities such as deductive,inductive,abductive,multi-hop,and causal inference are fundamental to robust decision making,trustworthy interaction,and ... relational reasoning,and cross-modal evidence integration.Reasoning abilities such as deductive,inductive,abductive,multi-hop,and causal inference are fundamental to robust decision making,trustworthy interaction,and real-world deployment,yet they have not been systematically examined in the LVLM literature.Existing surveys mainly discuss mathematical reasoning,general multimodal intelligence,or benchmark progress,but they do not provide a unified account of complex logical reasoning in LVLMs,including its definition,reasoning types,modeling paradigms,evaluation protocols,and unresolved limitations.To address this gap,this survey develops a unified analytical framework for complex logical reasoning in LVLMs.This survey provides a structured review of this emerging area.We first formalize complex logical reasoning in multimodal settings and organize the literature into five recurrent reasoning families:deductive,inductive,abductive,multi-hop,and causal reasoning.We then review reasoning-oriented LVLM architectures,including unified,modular,and tool-augmented paradigms,and summarize major reasoning mechanisms such as chain-of-thought,program-based reasoning,self-correction,and interpretability-oriented analysis.We further examine representative benchmarks and evaluation protocols,with particular attention to the mismatch between final-answer accuracy and genuine reasoning validity.Based on empirical evidence from representative LVLMs and datasets,we identify common capability trends,recurring failure modes,and key open challenges.Our analysis shows that current LVLMs still struggle with reasoning faithfulness,long-horizon inference,cross-modal grounding,hallucination control,and process-aware evaluation.Finally,we outline future directions in reasoning-oriented data construction,model design,training strategies,evaluation methodology,and deployment.Overall,this survey offers a unified conceptual framework and technical roadmap for advancing LVLMs from strong perceptual systems toward reliable multimodal reasoning agents. 展开更多
关键词 **:Large vision-language model complex logical reasoning multimodal reasoning chain-of-thought evaluation benchmark reasoning faithfulness
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A Short-Term Wind Power Forecasting Method Based on Adaptive BKA-TCN-BiLSTM Hybrid Model with AP Clustering 认领 引用
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作者 Mingxuan Ji Jing Gao +4 位作者 Dantian Zhong Yingqi Xu Shuxiang Yang Zhongxiao Du Yingming Liu 《Energy Engineering》 EI 2026年第8期277-296,共20页
The intermittency of wind power poses severe challenges to the safe and stable operation of power grids,while conventional forecasting models are deficient in prediction accuracy and adaptability to variable weather c... The intermittency of wind power poses severe challenges to the safe and stable operation of power grids,while conventional forecasting models are deficient in prediction accuracy and adaptability to variable weather conditions.To address these issues,this study proposes an adaptive short-term wind power forecasting model integrating affinity propagation(AP)clustering and a black-winged kite algorithm(BKA)-optimized temporal convolutional network-bidirectional long short-term memory(TCN-BiLSTM)hybrid architecture.First,mutual information was employed to screen key meteorological features,and AP clustering categorized historical data into six distinct weather scenarios.A scenario-specific TCN-BiLSTM model was then constructed for each cluster:TCN was utilized to capture multi-scale local temporal features,while BiLSTM modeled global sequence dependencies,with BKA implementing global hyperparameter optimization.Final predictions were generated by invoking the model corresponding to the nearest cluster center.Comparative experiments against baseline models(LSTM,BiLSTM,CNN-LSTM,TCN-BiLSTM)demonstrate that the proposed model achieves remarkable performance gains:normalized root mean square error(nRMSE),normalized mean absolute error(nMAE),and normalized mean square error(nMSE)are reduced by over 1.27%,1.73%,and 12.09%,respectively,with the coefficient of determination(R2)reaching 0.9084.This verifies substantial improvements in prediction accuracy and data fitting capability.The scenario-based modeling framework combined with intelligent hyperparameter optimization effectively enhances the model’s adaptability to complex weather,confirming its high accuracy and strong generalization for wind power forecasting tasks. 展开更多
关键词 TCN-BiLSTM weather scenarios BKA optimization algorithm wind power forecasting
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Technology of Radar Detection 认领 引用
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作者 Rui Hu Lei Pan +2 位作者 Jing Gao Haojie Hu Fang He 《Journal of Electronic Research and Application》 2026年第1期107-114,共8页
Radar detection technology utilizes radio waves for target detection,localization,and identification.It involves emitting electromagnetic waves and receiving the reflected echoes from targets,then analyzing the echo c... Radar detection technology utilizes radio waves for target detection,localization,and identification.It involves emitting electromagnetic waves and receiving the reflected echoes from targets,then analyzing the echo characteristics to obtain target information.This paper focuses on the fundamental principles,advantages,and disadvantages of radar detection technology.It emphasizes synthetic aperture radar(SAR),passive radar detection technology seeker,and millimeter-wave active homing guidance target identification technology,as well as the characteristics and development status of other detection methods such as phased array radar,showcasing the multi-directional development trend of radar detection technology. 展开更多
关键词 Radar detection technology Synthetic aperture radar(SAR) Passive radar detection technology Millimeter-wave active homing guidance target identification technology Development status
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Application Analysis of Tongue Muscle Training Combined with Respiratory Training Intervention for Dysphagia after Stroke 认领 引用
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作者 Ting Ye Jing Gao Zhaoxiang Meng 《Journal of Clinical and Nursing Research》 2026年第6期171-177,共7页
Objective:To explore the effects of tongue muscle training combined with respiratory training intervention on patients with dysphagia after stroke.Methods:A total of 70 patients with dysphagia after stroke admitted to... Objective:To explore the effects of tongue muscle training combined with respiratory training intervention on patients with dysphagia after stroke.Methods:A total of 70 patients with dysphagia after stroke admitted to our hospital from January 2025 to January 2026 were selected for the study and randomly divided into two groups.The control group(35 cases)underwent conventional rehabilitation training,while the observation group(35 cases)focused on tongue muscle training combined with respiratory training intervention.The intervention effects were compared between the two groups.Results:Before the intervention,there were no significant differences in swallowing function,respiratory function,and nutritional indicators between the two groups(p>0.05).After the intervention,the observation group showed greater improvements in tongue muscle strength and swallowing laryngoscopy scores,as well as lower dysphagia scores and better respiratory function,with significant differences compared to the control group(p<0.05).Conclusion:Tongue muscle training combined with respiratory training intervention can improve swallowing function and overall quality of life in patients with dysphagia after stroke,making it worthy of promotion. 展开更多
关键词 Tongue muscle training Respiratory training Stroke Dysphagia
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Mitophagy Pathways and Therapeutic Applications in Renal Fibrosis 认领 引用
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作者 Xinyue Yang Longhao Jia +3 位作者 Jing Gao Li Wang Jian Liu Ruizhi Tan 《Journal of Clinical and Nursing Research》 2026年第2期312-335,共24页
Chronic kidney disease(CKD),a global health burden,progresses through renal fibrosis driven by mitochondrial dysfunction in metabolically active renal cells.As the kidney harbors exceptionally high mitochondrial densi... Chronic kidney disease(CKD),a global health burden,progresses through renal fibrosis driven by mitochondrial dysfunction in metabolically active renal cells.As the kidney harbors exceptionally high mitochondrial density,defective mitophagy,a quality control mechanism for clearing damaged mitochondria have emerged as a central pathological trigger.Environmental toxins,such as perfluorinated compounds,disrupt lysosomal-mitochondrial crosstalk,exacerbating fibrotic pathways via metabolic reprogramming and sustained activation of pro-fibrotic signaling axes like FGF9/PI3K/Akt.Impaired PINK1/Parkin-mediated mitophagy permits accumulation of fragmented mitochondria,fueling oxidative stress and TGF-β/Smad3-driven epithelial-mesenchymal transition(EMT)and fibroblast activation.Recent therapeutic advances focus on restoring mitophagic flux to counteract fibrosis.Small-molecule activators(UMI-77)enhance mitochondrial clearance,attenuating NF-κB-mediated inflammation and collagen deposition.Nanotechnology-augmented mesenchymal stem cells offer targeted delivery of mitophagy modulators to damaged tubules,synergizing mitochondrial repair with anti-inflammatory effects.While preclinical studies highlight promising agents like SS-31 and MitoQ,challenges persist in achieving tissue-specific mitochondrial targeting and ensuring long-term genomic safety.This review synthesizes molecular insights into mitophagy dysregulation in fibrosis,explores innovative intervention strategies,and underscores the need for multi-omics approaches to optimize mitochondrial therapeutics.Bridging translational gaps through advanced delivery systems and patient-specific mitochondrial profiling may unlock precision therapies for halting CKD progression. 展开更多
关键词 Mitophagy Kidney Fibrosis Mitochondria
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Guidelines for the diagnosis and treatment of depressive disorders by integrating Chinese and Western medicine(English edition) 认领 引用 被引量：7
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作者 Lanying Liu Jianjun Wang +16 位作者 Wei Li Jing Gao Wangtao Li Yan Li Liyuan Luo Liyuan Guo Yiying Hu Yongjun Chen Hongyan Chen Lin Yu Bin Fen Hongxiao Jia Zhangjin Zhang Zhaojun Yan Wei Chen Zhangsheng Yu Zhen Wang 《General Psychiatry》 CAS CSCD 2025年第1期1-15,共15页
INTRODUCTION.Depressive disorders are mental illnesses that seriously affect public health.There are approximately 320 million patients with depression worldwide,accounting for 4.4% of the total disease burden.1Depres... INTRODUCTION.Depressive disorders are mental illnesses that seriously affect public health.There are approximately 320 million patients with depression worldwide,accounting for 4.4% of the total disease burden.1Depression leads to social and occupational impairment,diminished quality of life and an elevated risk of death by suicide. 展开更多
关键词 diagnosis mental illnesses depressive disorders chinese medicine western medicine treatment
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Development and identification of wheat-Psathyrostachys huashanica 7NsS small segment translocation lines with early heading date gene Ehd-7Ns 认领 引用 被引量：4
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作者 Binwen Tan Jing Gao +13 位作者 Zhijun Yao Wei Zhu Lili Xu Yiran Cheng Yi Wang Jian Zeng Xing Fan Lina Sha Haiqin Zhang Peng Qin Yinghui Li Yonghong Zhou Dandan Wu Houyang Kang 《The Crop Journal》 SCIE CAS CSCD 2025年第4期1186-1196,共11页
Psathyrostachys huashanica Keng ex P.C.Kuo(2n=2x=14,NsNs),a wild relative of wheat,represents a valuable germplasm resource for genetic improvement of wheat.We previously confirmed that a chromosome 7Ns from P.huashan... Psathyrostachys huashanica Keng ex P.C.Kuo(2n=2x=14,NsNs),a wild relative of wheat,represents a valuable germplasm resource for genetic improvement of wheat.We previously confirmed that a chromosome 7Ns from P.huashanica carries genes that accelerate heading and maturity in wheat.Here,we developed three small segment translocation lines(T7NsS-2BL 2BS,T7NsS-1AS 1AL#1,and T7NsS-1AS 1AL#2)along with one additional small segment translocation line(T7NsS-7BS 7BL)through60Co-γ irradiation,identified using genomic in situ hybridization(GISH),fluorescence in situ hybridization(FISH),and liquid chip array analyses.Our findings demonstrated that chromosome 7NsS contained a major early heading date gene,tentatively designated Ehd-7Ns,which was mapped to an approximate31.45 Mb region,corresponding to the short arm of wheat chromosome 7A(IWGSC RefSeq v1.0).The T7NsS-1AS 1AL#2 line exhibited no significant yield penalty and possessed superior agronomic traits relative to the other translocation lines in the field,making it a promising pre-breeding donor for breeding early maturing wheat.Furthermore,21 specific Kompetitive Allele Specific PCR(KASP)markers were developed based on transcriptome data,enabling effective tracing of alien chromosomal segments carrying this source of Ehd-7Ns in marker-assisted breeding.Collectively,these newly developed translocation lines and specific KASP markers will facilitate the transfer and utilization of favorable genes from P.huashanica chromosome 7Ns in future wheat breeding programs. 展开更多
关键词 Early maturity KASP markers Marker assisted selection Wheat breeding
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A comprehensive review on erosion-corrosion characteristics of steel subjected to tensile stress 认领 引用 被引量：2
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作者 Hua-kun Wang Ling Deng +2 位作者 Yao Zhang Yang Yu Jing Gao 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第7期1781-1802,共22页
Erosion-corrosion(EC)-induced damage is a primary contributor to premature failures in hydraulic transport structures involving sudden changes in flow patterns,especially the hydraulic pipeline(tee,reducer,pipe bend,e... Erosion-corrosion(EC)-induced damage is a primary contributor to premature failures in hydraulic transport structures involving sudden changes in flow patterns,especially the hydraulic pipeline(tee,reducer,pipe bend,etc.),pumps,and valves.A comprehensive exploration of EC behavior of steels subjected to high tensile stress was provided,as most engineering structures are operated under high stress.The stress-accelerated erosion(SAE)and stress-accelerated corrosion(SAC)behaviors of highly stressed steel and their synergistic effect were mainly focused.SAE,SAC,and their synergistic mechanisms,existing debate,and possible reasons,as well as available analytic models with their advantages and limitations,are thoroughly discussed.The multiphysics simulation methods for modeling EC interactions with both static and cyclic stresses are also summarized,and EC mitigation strategies,especially the bionics-based strategies,were also summarized in detail. 展开更多
关键词 Erosion-corrosion Stress-accelerated erosion-Stress-accelerated corrosion Mechanochemical interaction Multiphysics simulation
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Point mutations of Dicer2 conferred Fusarium asiaticum resistance to RNAi-related biopesticide 认领 引用 被引量：2
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作者 Kaixin Gu Ran Wei +6 位作者 Yidan Sun Xiaoxin Duan Jing Gao Jianxin Wang Yiping Hou Mingguo Zhou Xiushi Song 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第2期623-637,共15页
The use of RNA interference(RNAi)technology to control pests is explored by researchers globally.Even though RNA is a new class of pest control compound unlike conventional chemical pesticides,the evolution of pest re... The use of RNA interference(RNAi)technology to control pests is explored by researchers globally.Even though RNA is a new class of pest control compound unlike conventional chemical pesticides,the evolution of pest resistance needs to be considered.Here,we first investigate RNAi-based biopesticide resistance of Fusarium asiaticum,which is responsible for devastating diseases of plants,for example,Fusarium head blight.Five resistant strains were isolated from 500 strains that treated with UV-mutagenesis.The mutation common to all of the five resistant mutants occurred in the gene encoding Dicer2(point mutations at codon 1005 and 1007),which were under strong purifying selection pressure.To confirm whether the mutations in Dicer2 confer resistance to RNAi,we exchanged the Dicer2 locus between the sensitive strain and the resistant strain by homologous double exchange.The transformed mutants,Dicer2R1005Dand Dicer2E1007H,exhibited resistance to dsRNA in vitro.Further study showed that mutations of R1005D and E1007H affected the intramolecular interactions of Dicer2,resulting in the dysfunction of RNase III domain of Dicer2.The amount of sRNAs produced by Dicer2R1005Dand Dicer2E1007Hwas extremely reduced along with variation of sRNA length.Together,these findings revealed a new potential mechanism of RNAi resistance and provided insight into RNAi-related biopesticide deployment for fungal control. 展开更多
关键词 RNA interference dsRNA Dicer2 point mutation resistance Fusarium asiaticum
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Development of Fully Self-Controllable High-Finesse Optical Reference Cavities 认领 引用 被引量：3
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作者 Dongdong Jiao Mengfan Wu +9 位作者 Jing Gao Han Zhang Junlong Liu Guanjun Xu Qi Zang Jie Cui Ruifang Dong Tao Liu Bo Qu Shougang Zhang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2025年第1期53-57,共5页
High-finesse optical reference cavities are essential tools for fundamental research.In response to China’s historical reliance on importing high-finesse optical reference cavities,we successfully developed a cavity ... High-finesse optical reference cavities are essential tools for fundamental research.In response to China’s historical reliance on importing high-finesse optical reference cavities,we successfully developed a cavity using ultralow expansion glass(ULE)materials and processed it entirely in China.Using the method of measuring the cavity linewidth,a finesse of approximately 480000 was obtained in our experiments.We adopted a relatively simple and effective approach to test the optical reference cavity,which involved measuring the resonant points using an ultrastable laser.Remarkably,an expansion coefficient of the Chinese ULE optical reference cavity reached up to the order of 10-9/K within the temperature range of 27℃to 40℃,with the zero expansion point occurring at approximately 34oC.These findings demonstrate China’s independent capability to develop high-finesse optical reference cavities,which is a significant advancement in precision optics. 展开更多
关键词 optical cavity expansion
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Profiling the accumulation of ten bioactive compounds in Rheum officinale across different growth years using integrated HPLC and transcriptomic approaches 认领 引用 被引量：1
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作者 Yi-min Li Xue-ru Wang +6 位作者 Ge Yang Ting-ting Yan Xiao-chen Hu Liang Peng Jing Gao Feng Yan Gang Zhang 《Medicinal Plant Biology》 2025年第1期212-223,共12页
Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia.Variations in the composition and accumulation of secondary metabolites in R.officinale have been observed to correlate with harve... Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia.Variations in the composition and accumulation of secondary metabolites in R.officinale have been observed to correlate with harvest periods.This study investigated the progressive accumulation of six bioactive compounds in the roots and rhizomes of R.officinale over three growth years.Comparative transcriptome analyses were performed across three developmental stages of both root and rhizome tissues.In the root tissues,23 differentially expressed genes(DEGs)were observed,including CYP450,WRKY,UGT73C5,WAT1,and XTH15,which displayed significant differential expression patterns.Similarly,14 DEGs in the rhizome tissues showed significant differential expression,encompassing CYP450,WRKY,and UGT71A15.Short Time-series Expression Miner(STEM)analysis revealed that cluster 10(1,826 genes)in the root tissues was notably enriched in metabolic processes,predominantly involving WRKY,CYP450,and HSP gene families.In rhizome tissues,cluster 9(3,301 genes)included numerous gene families,with WRKY,CYP450,and UGT as the top three.Additionally,Weighted Gene Co-expression Network Analysis(WGCNA)was used to construct networks for 3,734 and 1,578 DEGs in root and rhizome tissues,respectively.Hub genes such as WRKY32 and CYP82G1 exhibited robust connectivity with other genes,suggesting their pivotal roles in pharmacopoeia indicator biosynthesis in root tissues.Moreover,CYP76T24,UGT71A15,and WRKY44 were identified as crucial genes in pharmacopoeia indicator biosynthesis in rhizome tissues.Collectively,these comprehensive results underscore the involvement of CYP450 and UGT in the biosynthetic pathways of bioactive compounds in R.officinale. 展开更多
关键词 rheum officinale Growth years bioactive compounds Transcriptomics Accumulation HPLC transcriptome analyses
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Super-Sensitive and Visibility-Enhanced Imaging with NOON States for Birefringent and Isotropic Samples 认领 引用
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作者 Shuang-Yin Huang Han-Bin Xi +7 位作者 Jing Gao Jing Wang Wen-Zheng Zhu Hao Li Chao Chen Zhi-Cheng Ren Xi-Lin Wang Hui-Tian Wang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2025年第10期129-143,共15页
As an emerging microscopic detection tool,quantum microscopes based on the principle of quantum precision measurement have attracted widespread attention in recent years.Compared with the imaging of classical light,qu... As an emerging microscopic detection tool,quantum microscopes based on the principle of quantum precision measurement have attracted widespread attention in recent years.Compared with the imaging of classical light,quantum-enhanced imaging can achieve ultra-high resolution,ultra-sensitive detection,and anti-interference imaging.Here,we introduce a quantum-enhanced scanning microscope under illumination of an entangled NOON state in polarization.For the phase imager with NOON states,we propose a simple four-basis projection method to replace the four-step phase-shifting method.We have achieved the phase imaging of micrometer-sized birefringent samples and biological cell specimens,with sensitivity close to the Heisenberg limit.The visibility of transmittance-based imaging shows a great enhancement for NOON states.Besides,we also demonstrate that the scanning imaging with NOON states enables the spatial resolution enhancement of√N compared with classical measurement.Our imaging method may provide some reference for the practical application of quantum imaging and is expected to promote the development of microscopic detection. 展开更多
关键词 birefringent samples isotropic samples quantum precision measurement noon states phase imager quantum enhanced imaging microscopic detection toolquantum microscopes phase imaging
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