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Relationship between preoperative modified frailty index,immune inflammation index,and outcomes of colorectal cancer surgery in older patients 认领 引用 被引量：2
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作者 Xing-Si Qi Nai-Ling Liu +1 位作者 Lin Yang Jing Xie 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期151-162,共12页
BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postopera... BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postoperative complications and affect long-term survival.AIM To assess modified frailty index(mFI)and systemic immune-inflammation index(SII)for predicting postoperative prognosis in older patients with CRC.METHODS We retrospectively analyzed 247 older patients with CRC who underwent radical resection.The SII was calculated as platelet count×neutrophil count/lymphocyte count.Patients were grouped by complication occurrence.Univariate and multivariate analyses were performed for mFI,SII,and postoperative complications.Using receiver operating characteristic curve analysis,the critical SII value for predicting postoperative recurrence was identified,which was then used to divide patients into high/low mFI and high/low SII groups.Using Kaplan-Meier method between-group survival curves were drawn.RESULTS The 30-day complication rate was 12.55%.Multivariate logistic regression analysis identified smoking history[odds ratio(OR)=4.822],prolonged operation time(OR=1.037),and elevated preoperative mFI(OR=9.342)and SII(OR=1.002)as independent risk factors for postoperative complications(P<0.05).On survival analysis,the average recurrence-free survival(RFS)for patients with a low mFI was 47.04 months[95%confidence interval(CI):45.30-48.79],significantly better than the 33.83 months(95%CI:31.31-36.36)for patients with a high mFI(log-rank,P<0.001).The average RFS for patients with a low SII was 47.00 months(95%CI:45.07-48.94),significantly better than the 40.06 months(95%CI:31.37-43.74)for those with a high SII(log-rank,P<0.001).CONCLUSION In older patients with CRC,the preoperative mFI and SII were significantly correlated with postoperative complications and RFS,warranting closer attention to early recurrence detection and intervention. 展开更多
关键词 Colorectal cancer Laparoscopic radical resection Postoperative complications Recurrence-free survival Modified frailty index Systemic immune-inflammation index
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Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis 认领 引用
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作者 Mengmeng Duan Chenchen Zhou +15 位作者 Guanyue Su Chunhe Zhang Jie Ren Qingjia Chi Xiaojing Liu Li Yang Haiqing Bai Yang Claire Zeng Seongmin Kim Yunhao Zhai Crystal Yuri Oh Adam Yongxin Ye Yuting Chen Longlong Si Xiaoheng Liu Jing Xie 《Bone Research》 SCIE CAS CSCD 2026年第1期274-290,共17页
Cells actively sense and transduce microenvironmental mechanical inputs into chemical signals via cytoskeletal rearrangements.During these mechanosensation and mechanotransduction processes,the role of the actin cytos... Cells actively sense and transduce microenvironmental mechanical inputs into chemical signals via cytoskeletal rearrangements.During these mechanosensation and mechanotransduction processes,the role of the actin cytoskeleton is well-understood,whereas the role of the tubulin cytoskeleton remains largely elusive.Here,we report the dynamic changes in microtubules in response to microenvironmental stiffness during chondrocyte mitosis.Mechanical stiffness was found to be coupled with microtubule generation,directing microtubule dynamics in mitotic chondrocytes.Refilin B was found to be a key regulator of microtubule assembly in chondrocytes in response to mechanical stiffness.It was found to play its role in microtubule formation via the p-Smad3 signaling pathway.Additionally,integrin-linked kinase(ILK),triggered by mechanical stiffness,was found to play an indispensable role in the process of microtubule dynamics mediated by refilin B.Our data emphasizes stiffness-mediated dynamic changes in the microtubules of chondrocytes in a quiescent state(G0)and at anaphase,which improves our understanding of the mechanical regulation of microtubule assembly during the chondrocyte cell cycle and provides insights into microenvironment mechanics during tissue maintenance,wound healing,and disease occurrence. 展开更多
关键词 actin cytoskeleton microtubule dynamics tubulin cytoskeleton cytoskeletal rearrangementsduring mechanotransduction processesthe chondrocyte mitosismechanical dynamic changes microtubules chondrocyte mitosis
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Moringa oleifera Lam.leaves-induced food allergic responses by modulating the Th1/Th2 immune balance in a multi-functional mode 认领 引用
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作者 Shuang Song Chuyu Xi +8 位作者 Hairan Su Xiaoxue Liu Hao Yang Wenjie Li Jing Xie Liang Tao Shijun Li Jun Sheng Yang Tian 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2285-2293,共9页
Some visitors to India often experience diarrhea and attribute it to Indian food;however,murine food allergy model have shown that diarrhea occurring after consumption of Moringa may be due to an allergic reaction.The... Some visitors to India often experience diarrhea and attribute it to Indian food;however,murine food allergy model have shown that diarrhea occurring after consumption of Moringa may be due to an allergic reaction.The findings of this study indicate that Moringa leaf protein(Mo-Pr)has the potential to sensitize BALB/c mice.Mo-Pr has been demonstrated to stimulate the mice's production of Mo-Pr-specific immunoglobulin E,promote mast cell degranulation,and induce the release of histamine and other inflammatory mediators.Mo-Pr has been demonstrated to promote the proliferation and differentiation of Th2 cells while simultaneously inhibiting the proliferation and differentiation of Thl and Treg cells.The sera Western blot shown that the significant band Mo-Pr molecule weight is 36 kDa respectively,which was identified as fructose-1,6-bisphosphate aldolase by liquid chromatographytandem mass spectrometry. 展开更多
关键词 Moringa oleifera Lam. Moringa leaf protein Food allergy Murine food allergy model Fructose-1,6-bisphosphate aldolase
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Consolidation-sealing of in-situ internal stress in deep rocks: Device development and mechanical behavior characterization 认领 引用
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作者 Mingzhong Gao Chuo Zhang +5 位作者 Fei Li Bengao Yang Jing Xie Zundong Yang Kunchen He Haichun Hao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2026年第4期709-723,共15页
Addressing the scientific problem of unclear understanding of in-situ internal stress and its evolution in deep rock masses,a scientific definition and implementation path for the concept of in-situ internal stress co... Addressing the scientific problem of unclear understanding of in-situ internal stress and its evolution in deep rock masses,a scientific definition and implementation path for the concept of in-situ internal stress consolidation-sealing in deep rock masses are proposed,and a set of in-situ internal stress consolidationsealing test device for deep rock masses has been independently developed.The device consists of a material consolidation cultivation module,an in-situ internal stress environment simulation module,and a multi-source information capture module.And the three mechanical tests of internal stress preservation,internal stress release and conventional were carried out with the device.The evolution law of the deformation parameters in the internal stress consolidation-sealing stage was studied,and the difference characteristics of the deformation parameters before and after the internal stress releasing were compared and analyzed.The results show that the internal stress consolidation-sealing significantly affects the mechanical properties of the simulated rock material,while the internal stress release leads to the damage of the material properties,suggesting that the presence and influence of internal stress should not be overlooked.This study could provide a new research direction and scientific devices for the expansion and deepening of the field of deep in-situ rock mechanics. 展开更多
关键词 Deep rock mass In-situ rock mechanics Internal stress consolidation-sealing Test device
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Role of bpfA in adhesion and biofilm formation of Shewanella putrefaciens CN32 under cold stress:a comprehensive transcriptomic analysis 认领 引用
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作者 Zhenghao Guo Ruheng Xiong +1 位作者 Jun Yan Jing Xie 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期125-135,共11页
As a specific spoilage organism of seafood under refrigerated temperature conditions,Shewanella spp.tend to form biofilms that exacerbate the occurrence of seafood spoilage.Biofilm-promoting factor A(BpfA)has been rep... As a specific spoilage organism of seafood under refrigerated temperature conditions,Shewanella spp.tend to form biofilms that exacerbate the occurrence of seafood spoilage.Biofilm-promoting factor A(BpfA)has been reported to promote the adhesion and biofilm formation of Shewanella spp.,but its role in adhesion and biofilm formation of S.putrefaciens under cold stress needs to be further investigated.To better comprehend the effect of BpfA on adhesion and biofilm formation of S.putrefaciens under cold stress(4℃),bacterial adhesion and biofilm phenotype of S.putrefaciens CN32 WT andΔbpfA at 4℃were analyzed and performed transcriptomics.The results showed that the deletion of bpfA had almost no effect on the growth of S.putrefaciens CN32 at 4℃,but weakened the unicellular adhesion capacity of S.putrefaciens CN32 and destabilized the stability of the multicellular adhesion layer.In addition,the biomass of the mature biofilm formed byΔbpfA was merely around 50%of that observed in the mature biofilm of S.putrefaciens CN32 WT,the average thickness and volume of the biofilm decreased by 18%and 27%,respectively,and the composition of the biofilm changed.Transcriptome analysis demonstrated that the deletion of bpfA led to differential expression of genes involved in metabolic pathways such as bacterial chemotaxis,two-component system,tyrosine metabolism,drug metabolism-other enzymes and biofilm formation-Vibrio cholerae,which in turn influenced bacterial adhesion and biofilm formation.Those results advance our acknowledgment of the character of BpfA on adhesion and biofilm formation of S.putrefaciens CN32,which contributes to understanding bacterial adhesion and the control of biofilm formation. 展开更多
关键词 Shewanella putrefaciens Cold stress BpfA Adhesion Biofilm Transcriptomics
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Cellular-nanoporation boosts high-yield RVG-modified exosomes for multifunctionalα-synuclein scavengers against Parkinson's disease 认领 引用
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作者 Meng Sun Leijie Yu +12 位作者 Lu Bai Xingyou Liu Ying Xiong Xia Zhao Xing Zhong Mengqiong Ran Yu Wang Xinlei Yan Chenhui Wang Robert J.Lee Yaqin Tang Wuyang He Jing Xie 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期605-609,共5页
The pathological proteinα-synuclein(α-Syn)aggregates are considered a key toxic substance responsible for the degeneration of dopaminergic neurons in Parkinson's disease(PD).Clearing these pathological aggregate... The pathological proteinα-synuclein(α-Syn)aggregates are considered a key toxic substance responsible for the degeneration of dopaminergic neurons in Parkinson's disease(PD).Clearing these pathological aggregates can potentially control PD progression at its source.However,conventional drug delivery systems face significant challenges,including the blood-brain barrier(BBB)and lack of tissue-specific targeting.To address this,we developed a core-shell hybrid system,named RExo-si-TN-T10,for the co-delivery of triptolide(T10)and small interfering RNA targetingα-Syn(siSNCA).This system comprises two components:an outer shell of exosomes(RExo)derived from BV2 microglial cells and modified with rabies virus glycoprotein peptide(RVG),and an inner core of a nanomicelle composed of phenylboronic acid derivatives:4-Nitrophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonate(NBC)and trimethyl chitosan(TMC)for co-delivering gene and small-molecule drugs.Furthermore,we utilized cellular nanoporation(CNP)technology to significantly enhance exosome yield and transfection efficiency.This innovative nano-scavenger effectively eliminatesα-Syn aggregates and reduces their cytotoxic effects in PD-affected neurons.Following treatment with RExo-si-TN-T10,we observed significant improvement in the motor behavior of PD mice.Our findings suggest that RExo-si-TN-T10 holds promise as a therapeutic platform for PD. 展开更多
关键词 Parkinson's disease Targeted delivery ROS response Exosome α-Syn RNAi BBB
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Walnut green husk polyphenols ameliorate type 2 diabetes in C57BL/6 mice by the gut microbiota and IRS/PI3K/AKT signaling pathway 认领 引用
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作者 Xia Hu Jing Xie +3 位作者 Zishan Hong Yuexiu Pan Jun Sheng Yang Tian 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3442-3455,共14页
Walnut green husk,a byproduct of walnut processing,is rich in polyphenols with potential antidiabetic effects.However,the antidiabetic activity of walnut green husk polyphenols(WGHP)in vivo has not been reported and t... Walnut green husk,a byproduct of walnut processing,is rich in polyphenols with potential antidiabetic effects.However,the antidiabetic activity of walnut green husk polyphenols(WGHP)in vivo has not been reported and their mechanism of action is still unclear.This study investigated its impact on type 2 diabetes mellitus(T2DM)in mice induced by a high-fat diet and streptozotocin.We found that WGHP improved glycolipid metabolism,reduced inflammation and oxidative stress,and protected the pancreas and liver.WGHP also reshaped the gut microbiota,lowering the Firmicutes/Bacteroidota ratio and boosting beneficial bacteria.Network pharmacology indicated that WGHP's effects are mediated by the PI3K/AKT signaling pathway,which was confirmed by increased protein expression of phosphorylated insulin receptor substrate 1(p-IRS-1),phosphoinositide 3-kinase(PI3K),phosphorylated protein kinase B(p-AKT),and glucose transporter type 4(GLUT4)in the liver.In conclusion,these results indicate that WGHP ameliorates T2DM by modulating gut microbiota and the IRS/PI3K/AKT pathway,providing a theoretical basis for the in-depth utilization of walnut green husk. 展开更多
关键词 Walnut green husk polyphenols Type 2 diabetes mellitus(T2DM) Network pharmacology Gut microbiota IRS/PI3K/AKT pathway
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Sulfur-Doped Carbon Matrix-Coated Co1-xS/Ni0.96S@NC Rhombic Cubes Significantly Enhanced the Storage Performance and Kinetics of Lithium/Sodium-Ion Batteries 认领 引用
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作者 Wenjin Qin Yongming Jin +5 位作者 Yong Guo Qiuye Deng Jing Xie Jindou Hu Zhenjiang Lu Yali Cao 《Rare Metals》 SCIE EI CAS CSCD 2026年第1期683-695,共13页
Metal sulfide,as a type of lithium/sodium-ion battery material,possesses merits such as high capacity and low cost.Nevertheless,it is prone to structural changes during the cycling process,leading to volume changes an... Metal sulfide,as a type of lithium/sodium-ion battery material,possesses merits such as high capacity and low cost.Nevertheless,it is prone to structural changes during the cycling process,leading to volume changes and affecting electrochemical performance.Here,we employ a gas-phase deposition method to subject the Co-Ni-NH2 precursor to hightemperature carbonization/sulfidation,which produces defective nitrogen-and sulfur-co-doped carbon-encapsulated bimetallic sulfides(CO1-xS/Ni0.96S@NC).Incorporating S into the carbon lattice facilitates the expansion of interlayer spacing,creating an environment conducive to Li+/Na+ insertion/extraction.Furthermore,leveraging the synergistic effect of bimetallic sulfides accelerates the reaction kinetics for storing alkaline metal ions and exhibits higher capacity.The X-ray photoelectron spectroscopy(XPS) depth profiling analysis of the cycled Co1-xS/Ni0.96S@NC reveals the stable formation of a solid electrolyte interphase(SEI) film on the sample surface,and ex situ X-ray diffraction(XRD) indicates that the storage mechanism of Co1-xS/Ni0.96S@NC involves a highly reversible conversion reaction.As a result,Co1-xS/Ni0.96S@NC as the anode for lithiumion batteries(LIBs) exhibits an outstanding capacity and demonstrates remarkable stability with a capacity retention of381.12 mAh g-1 after 800 cycles at 10 A g-1.Furthermore,the full battery LiCoO2//Co1-xS/Ni0.96S@NC is capable of attaining a discharge-specific capacity at 3 A g-1 for 154.92 mAh g-1.Besides,in sodium-ion batteries(SIBs),Co1-xS/Ni0.96S@NC maintains a specific capacity of 336.10 mAh g-1 over 1000 cycles at 5 A g-1.In summary,Co1-xS/Ni0.96S@NC,characterized by high stability and high specific capacity,emerges as a highly promising candidate material for high-performance lithium/sodium-ion batteries. 展开更多
关键词 bimetallic sulfides diamond-shaped morphology lithium/sodium-ion batteries nitrogen-doped carbon
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Fracturing behavior of tight sandstone containing hollow double-wing crack(HDWC)under microwave irradiation 认领 引用
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作者 Zeyu Zhu Jing Xie +8 位作者 Yuze Du Li Ren Bengao Yang Gan Feng Mingxin Liu Ting Ai Ruifeng Tang Yunlong Wang Mingzhong Gao 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第3期2215-2237,共23页
As an emerging rock-breaking technology,microwave irradiation has demonstrated significant potential as an auxiliary technique for volume stimulation in hydraulic fracturing.This study focuses on tight sandstone gas e... As an emerging rock-breaking technology,microwave irradiation has demonstrated significant potential as an auxiliary technique for volume stimulation in hydraulic fracturing.This study focuses on tight sandstone gas extraction,introducing a hollow double-wing crack(HDWC)configuration into the research on tight sandstone.Laboratory experiments were conducted to investigate microwave-induced fracturing mechanisms and the mechanical behavior of HDWC-containing sandstone,aiming to elucidate the thermal cracking patterns and underlying mechanisms under microwave irradiation conditions.To further explore the electromagnetic-thermal-mechanical(E-T-M)interactions in tight sandstone under microwave treatment,a coupled finite element method(FEM)-discrete element method(DEM)numerical model was developed.This model enabled a detailed analysis of force chain evolution and microcrack propagation within HDWC-containing sandstone.Additionally,preliminary hydraulic fracturing simulations were performed to investigate fracture initiation pressure and fracture evolution following microwave exposure.The main findings of this study are as follows:(1)Microwave heating induces thermal cracks at both the tips and midsections of the HDWC.Microwave irradiation degrades the mechanical properties of HDWC-containing sandstone.(2)Simulation results reveal that significant stress concentration and tensile-compressive zoning occur near the HDWC under microwave irradiation.Microcrack development exhibits an avalanche effect.(3)Hydraulic fracturing simulations indicate that microwave heating generally promotes hydraulic fracture generation.Microwave irradiation reduces the fracture initiation pressure and enhances the complexity and connectivity of the fracture network.These findings provide valuable insights into the application of microwave-assisted volume stimulation as a supporting technology for hydraulic fracturing in deep reservoirs. 展开更多
关键词 Microwave-assisted hydraulic fracturing Tight sandstone Numerical simulation Finite element method-discrete element method(FEM-DEM)
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Novel perspective on spoilage metabolism of refrigerated large yellow croaker(Larimichthys crocea)under air-packaging and modified atmosphere-packaging:insights into adenosine triphosphate degradation 认领 引用
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作者 Tiansheng Xu Qi Yan +2 位作者 Bohan Chen Dapeng Li Jing Xie 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3337-3347,共11页
This study evaluated the spoilage potential of dominant bacteria(Shewanella putrefaciens and Pseudomonas fluorescens)on the effect of the deterioration of adenosine triphosphate-related compounds in refrigerated large... This study evaluated the spoilage potential of dominant bacteria(Shewanella putrefaciens and Pseudomonas fluorescens)on the effect of the deterioration of adenosine triphosphate-related compounds in refrigerated large yellow croaker fillets under air-packaging and modified atmosphere packaging(MAP).In this work,the total viable count(TVC),adenosine triphosphate-related compounds,and related enzyme activities were characterized in refrigerated large yellow croaker fillets inoculated spoilage bacteria.Macrogenomic analysis was employed to explore the contribution of packaging methods to metabolic pathways and related enzymes.The result demonstrated that the TVC of S.putrefaciens reached 7.85(lg(CFU/g))on day 21,exhibiting stronger potential for growth in MAP.The results showed that S.putrefaciens had a higher potential to degrade adenosine triphosphate-related compounds and produce related enzyme activities under MAP conditions than P.fluorescens.The initial value of hypoxanthine riboside(HxR)during storage in the air processing(AIRP)group was 0.76μmol/g,which reached a peak on day 3(1.71μmol/g),and the level of HxR decreased to 0.38μmol/g on day 12.The MAP group showed a similar trend to the AIRP group,but the peak appeared later than the AIRP group.The ability to degrade HxR in S.putrefaciens exhibited a significant difference in air packaging.In addition,macrogenomic analysis indicated that the degradation of inosine monophosphate(IMP)was primarily performed by 5'-nucleotidase(5'-NT).This study enhances our comprehension of the role of microorganisms in fish spoilage and provides valuable insights for the development of novel preservation methods. 展开更多
关键词 Large yellow croaker Modified atmosphere packaging Adenosine triphosphate ATP-degrading related enzymes Macrogenomic
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基于创新能力培养的无机化学实验教学改革与实践 认领 引用 被引量：1
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作者 邱江华 陈阳 +2 位作者 唐艳 谢静 张雄志 《大学化学》 CAS 2026年第4期208-215,共8页
本文总结了武汉科技大学化学与化工学院在无机化学实验课程改革方面的实施情况,通过建立线上线下混合式教学模式、提升综合性和设计性实验的比例、全过程融入思政教育、实施多元化综合评价机制等,有效提升学生的实验操作技能、实验设计... 本文总结了武汉科技大学化学与化工学院在无机化学实验课程改革方面的实施情况,通过建立线上线下混合式教学模式、提升综合性和设计性实验的比例、全过程融入思政教育、实施多元化综合评价机制等,有效提升学生的实验操作技能、实验设计能力、创新思维、安全环保素养和社会责任感,显著提高了教学效果。 展开更多
关键词 无机化学实验 创新能力培养 线上线下混合式教学 课程思政
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Photothermal sensitive nanocomposite hydrogel for infectious bone defects 认领 引用 被引量：8
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作者 Yanting Wu Xi Xie +7 位作者 Guowen Luo Jing Xie Xiuwen Ye Wanrong Gu Anchun Mo Zhiyong Qian Chenchen Zhou Jinfeng Liao 《Bone Research》 SCIE CAS CSCD 2025年第2期320-338,共19页
Infectious bone defects represent a substantial challenge in clinical practice,necessitating the deployment of advanced therapeutic strategies.This study presents a treatment modality that merges a mild photothermal t... Infectious bone defects represent a substantial challenge in clinical practice,necessitating the deployment of advanced therapeutic strategies.This study presents a treatment modality that merges a mild photothermal therapy hydrogel with a pulsed drug delivery mechanism.The system is predicated on a hydrogel matrix that is thermally responsive,characteristic of bone defect sites,facilitating controlled and site-specific drug release.The cornerstone of this system is the incorporation of mild photothermal nanoparticles,which are activated within the temperature range of 40–43°C,thereby enhancing the precision and efficacy of drug delivery.Our findings demonstrate that the photothermal response significantly augments the localized delivery of therapeutic agents,mitigating systemic side effects and bolstering efficacy at the defect site.The synchronized pulsed release,cooperated with mild photothermal therapy,effectively addresses infection control,and promotes bone regeneration.This approach signifies a considerable advancement in the management of infectious bone defects,offering an effective and patient-centric alternative to traditional methods.Our research endeavors to extend its applicability to a wider spectrum of tissue regeneration scenarios,underscoring its transformative potential in the realm of regenerative medicine. 展开更多
关键词 incorporation mild photothermal nano bone defects treatment modality bone defect advanced therapeutic strategiesthis photothermal therapy hydrogel matrix mild photothermal therapy hydrogel
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The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy 认领 引用 被引量：5
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作者 Jianwei Shi Jing Xie +4 位作者 Zesheng Li Xiaosong He Penghu Wei Josemir W Sander Guoguang Zhao 《Neuroscience Bulletin》 SCIE CAS CSCD 2025年第5期881-905,共25页
Epilepsy affects over 50 million people worldwide.Drug-resistant epilepsy(DRE)accounts for up to a third of these cases,and neuro-inflammation is thought to play a role in such cases.Despite being a long-debated issue... Epilepsy affects over 50 million people worldwide.Drug-resistant epilepsy(DRE)accounts for up to a third of these cases,and neuro-inflammation is thought to play a role in such cases.Despite being a long-debated issue in the field of DRE,the mechanisms underlying neuroinflammation have yet to be fully elucidated.The pro-inflammatory microenvironment within the brain tissue of people with DRE has been probed using single-cell multimodal transcriptomics.Evidence suggests that inflammatory cells and pro-inflammatory cytokines in the nervous system can lead to extensive biochemical changes,such as connexin hemichannel excitability and disruption of neurotransmitter homeostasis.The presence of inflammation may give rise to neuronal network abnormalities that suppress endogenous antiepileptic systems.We focus on the role of neuroinflammation and brain network anomalies in DRE from multiple perspectives to identify critical points for clinical application.We hope to provide an insightful overview to advance the quest for better DRE treatments. 展开更多
关键词 Neuroglia Neuro-immune interaction Brain network Chronicity Epilepsy
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Sea urchin-like NiPt/TiCeO2catalyst for rapid and efficient hydrogen production from hydrous hydrazine 认领 引用 被引量：4
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作者 Wenting Ren Shuyu Liu +6 位作者 Yan Wang Jing Xie Chao Wan Lixin Xu Shenglai Li Jiapei Wang Pavel S.Postnikov 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第8期1668-1676,I0003,共9页
Controllable hydrogen production via the catalytic decomposition of hydrous hydrazine(N2H4·H2O)holds significant promise for mobile and portable applications.However,current catalysts suffer from unsatis... Controllable hydrogen production via the catalytic decomposition of hydrous hydrazine(N2H4·H2O)holds significant promise for mobile and portable applications.However,current catalysts suffer from unsatisfactory reaction activity and hydrogen(H2)selectivity.Based on the unique redox properties of CeO2,this article aims to enhance the thermal catalytic performance for the decomposition of N2H4·H2O by improving metal-support interactions between the TiCeO2and NiPt active components.Meanwhile,the sea urchin-like TiCeO2support,which is more conducive to the dispersion of the NiPt nanoparticles and provides more reactive sites for the reaction,was used to immobilize Ni-Pt into the NixPt1-x/TiCeO2sample using the impregnation-reduction method.By modulating Ce doping and the Ni-Pt molar ratio,samples with different Ni-Pt compositions were synthesized.The optimal Ni0.5Pt0.5/TiCeO2(nNi:nPt=1)shows the highest catalytic performance compared with the other samples,with a TOF(turnover frequency)of 212.58 min-1and 100%hydrogen selectivity at 323 K.Furthermore,the hydrogen selectivity remains 100%after six cycles.This remarkable activity and stability provide valuable insights and encouragement for accelerating the practical application of N2H4·H2O as a viable hydrogen carrier. 展开更多
关键词 Hydrous hydrazine Hydrogen production Decomposition Nickel-platinum bi-metal catalyst Rare earths
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Constructing urchin-like TiO2 integrated NiPt nanoparticles for boosting the decomposition of hydrazine hydrate 认领 引用 被引量：3
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作者 Shu-Yu Liu Wen-Ting Ren +7 位作者 Lei-Yun Chen Jing Xie Chao Wan Li-Xin Xu Sheng-Lai Li Jia-Pei Wang Pavel S.Postnikov Dang-Guo Cheng 《Rare Metals》 SCIE EI CAS CSCD 2025年第9期6331-6342,共12页
Chemical hydrogen storage technology is crucial for the widespread use of hydrogen,with significant research progress being made in hydrazine hydrate(N2H4·H2O).However,the efficient decomposition of N_(2... Chemical hydrogen storage technology is crucial for the widespread use of hydrogen,with significant research progress being made in hydrazine hydrate(N2H4·H2O).However,the efficient decomposition of N2H4·H2O remains a major challenge,hindered by dynamic constraints.To address this,we prepared NiPt nanoparticles deposited onto urchin-like TiO2(u-TiO2)using the impregnation-reduction method,resulting in the NiPt/u-TiO2catalyst.Remarkably,the Ni0.5Pt0.5/u-TiO2catalyst demonstrated 100%H2selectivity,ultrahigh catalytic activity and remarkable durability for N2H4·H2O dehydrogenation,with a turnover frequency(TOF)of115.8 min-1,surpassing that of the corresponding NiPt/commercial TiO2(c-TiO2).Characterization and experimental findings suggest that the remarkable activity may originate from the unique urchin-like structure of the catalyst,along with the synergistic interaction between NiPt metals and the support.This research opens new avenues for designing nanomaterials with morphology advantages for hydrogen evolution reaction. 展开更多
关键词 Hydrogen Hydrazine hydrate Hydrogen storage materials NiPt catalyst Urchin-like TiO2
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Investigation on the physical–mechanical response characteristics and failure mechanisms of shale under the laser thermal field 认领 引用 被引量：2
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作者 Yuze Du Jing Xie +7 位作者 Zheqiang Jia Li Ren Zeyu Zhu Junjun Liu Lei Yang Ting Ai Bengao Yang Mingzhong Gao 《International Journal of Coal Science & Technology》 SCIE EI CAS CSCD 2025年第2期158-181,共24页
The mainstream method for extracting shale gas involves hydraulic fracturing to create fracture networks.However,as extraction depth increases,notable issues such as rapid production decline,low recovery rates,high wa... The mainstream method for extracting shale gas involves hydraulic fracturing to create fracture networks.However,as extraction depth increases,notable issues such as rapid production decline,low recovery rates,high water consumption,and resource waste become apparent.Identifying new and efficient auxiliary rock-breaking technologies is crucial for overcoming these challenges.The laser,successfully utilized in industrial production,medical treatment,and technological research,offers unique features such as good directionality,coherence,and high energy density,providing novel possibilities for addressing the limitations of existing deep reservoir transformation.This research focuses on a novel laser-assisted rock-breaking technology,with shale featuring different bedding angles as the subject of investigation.The investigation methodically explored how shale responded to thermal fracture at high temperatures when exposed to laser irradiation with different spot diameter.It investigates the spatiotemporal evolution characteristics of the shale temperature field under laser irradiation,the propagation features of cracks on shale surface,and the physicochemical fracture mechanisms.The research yields the following results:(1)The region of thermal influence of the irradiation surface can be divided into three regions based on the change of rise curve of temperature in the shale surface.(2)Based on the scanning electron microscopy(SEM)testing,combined with the macroscopic and microscopic morphological characteristics of shale fracture surfaces,it reveals significantly distinct zoning characteristics in the roughness of the rock sample’s fracture surfaces after laser irradiation.(3)The thermal fracturing process of shale under laser irradiation involves chemical reactions of constituent minerals and stress generated by the thermal expansion of shale oil in the reservoir.(4)The damage and fracture of shale under the irradiation of laser show significant bedding effect,and there are three modes of rock sample failure:Pattern T(thermal failure),Pattern T-B(thermal and bedding synergistic failure),and Pattern B(bedding failure).The research findings presented in this article serve as a foundation and reference for the theory and technology of laser-assisted shale gas extraction. 展开更多
关键词 Shale Laser Bedding effect Crack propagation Fracture mechanism
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3D inversion imaging of self-potential current source induced by mineral polarization 认领 引用 被引量：2
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作者 Li-juan ZHANG Yi-an CUI +1 位作者 Jing XIE Jian-xin LIU 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2025年第3期945-953,共9页
An innovative gradient inversion approach employing the natural element method within the framework of least square regularization was proposed to enhance the quantitative interpretation of self-potential(SP)data orig... An innovative gradient inversion approach employing the natural element method within the framework of least square regularization was proposed to enhance the quantitative interpretation of self-potential(SP)data originating from mineral polarization.The results indicated that the natural element method effectively addressed the challenge of subdividing complex resistivity models and aided in the accurate forward calculation of SP.By applying this approach to synthetic SP data and lab-measured SP data associated with redox electrochemical half-cell reactions of iron−copper metal blocks within the geobattery model,the 3D fine structure of buried orebody models was successfully reconstructed and the spatial distribution of SP current sources was mapped.This study significantly contributes to understanding the quantitative relationship between the polarization process of metal deposits and their corresponding SP responses and provides a valuable reference for delineating metal deposits in both terrestrial and marine environments through SP surveys. 展开更多
关键词 mineral polarization self-potential natural element method gradient inversion
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Robot-assisted percutaneous coronary intervention:a prospective,multicenter,randomized controlled,non-inferiority clinical trial 认领 引用 被引量：1
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作者 Yi YU Zheng CHEN +7 位作者 Zhi-Jian WANG Yue-Ping LI Li-Xia YANG Jing QI Jing XIE Tao HUANG Dong-Mei SHI Yu-Jie ZHOU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2025年第8期725-735,共11页
OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicent... OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicenter,randomized controlled,non-inferior clinical trial enrolled patients with coronary heart disease who met the inclusion criteria and had indications for elective percutaneous coronary intervention.Participants were randomly assigned to either the R-PCI group or the M-PCI group.Primary endpoints were clinical and technical success rates.Clinical success was defined as visually estimated residual post-percutaneous coronary intervention stenosis<30% with no 30-day major adverse cardiac events.Technical success in the R-PCI group was defined as successful completion of percutaneous coronary intervention using the ETcath200 robot-assisted system,without conversion to M-PCI in the event of a guidewire or balloon/stent catheter that was unable to cross the vessel or was poorly supported by the catheter.Secondary endpoints included total procedure time,percutaneous coronary intervention procedure time,fluoroscopy time,contrast volume,operator radiation exposure,air kerma,and dose-area product.RESULTS The trial enrolled 152 patients(R-PCI:73 patients,M-PCI:79 patients).Lesions were predominantly B2/C type(73.6%).Both groups achieved 100% clinical success rate.No major adverse cardiac events occurred during the 30-day follow-up.The R-PCI group had a technical success rate of 100%.The R-PCI group had longer total procedure and fluoroscopy times,but lower operator radiation exposure.The percutaneous coronary intervention procedure time,contrast volume,air kerma,and dose-area product were similar between the two groups.CONCLUSIONS For certain complex lesions,performing percutaneous coronary intervention using the ETcath200 robot-assisted system is safe and effective and does not result in conversion to M-PCI. 展开更多
关键词 complex lesions non inferiority clinical trial technical success operator radiation exposure robot assisted percutaneous coronary intervention coronary heart disease elective percutaneous coronary interventionparticipants traditional manual percutaneous coronary intervention m pci methods
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Fatigue characteristics of deep excavation-disturbed jinping marble 认领 引用 被引量：1
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作者 Anlin Zhang Ru Zhang +6 位作者 Ting Ai Li Ren Zetian Zhang Jing Xie Chendi Lou Kun Xiao Zeqian Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2025年第1期341-356,共16页
Deep rocks encountered in underground engineering are frequently in complex in situ environments and experience both excavation disturbance during construction and cyclic loading throughout the long-term operation. Un... Deep rocks encountered in underground engineering are frequently in complex in situ environments and experience both excavation disturbance during construction and cyclic loading throughout the long-term operation. Understanding the fatigue behavior of excavation-disturbed rocks in complex stress environments is critical for assessing the long-term stability of deep rock structures. Hence, an experimental method has been developed to capture the fatigue damage process of rocks while considering the in situ environment and excavation disturbance. Using this method, a series of triaxial fatigue damage experiments were conducted on Jinping deep marble samples from various in situ environments of 100 m, 1000 m, 1800 m, and 2400 m to better understand the variation in fatigue characteristics at different depths. With increasing depth, the samples experienced more cycles and greater fatigue deformation before failure. Further insights were gained into the fatigue damage behavior in terms of stiffness degradation, energy dissipation and irreversible strain accumulation. A decrease in the elastic modulus and an increase in the dissipated energy and irreversible strain exhibit an evolution pattern of initial→stabilization→acceleration, reflecting the nonlinear fatigue process that occurs inside marble. With increasing depth, marble samples have longer fatigue lives but exhibit more significant stiffness loss, energy dissipation and irrecoverable deformation accumulation;thus, evaluating the instability of deep rock structures solely using fatigue life alone is inadequate. Moreover, the previously reported inverted S-shaped evolution of fatigue damage was observed, and it was found that an increase in depth leads to an earlier onset of the accelerated fatigue damage stage with greater dominance of fatigue failure. Based on the nonlinear strain, loading cycle variable and fatigue life, a highly accurate nonlinear fatigue model was developed to describe the complete inverted S-shaped evolution pattern of fatigue damage, which demonstrated excellent practical implications for the theoretical characterization of anisotropic fatigue damage in disturbed Jinping marble. 展开更多
关键词 Excavation-disturbed rock In situ environment Fatigue behavior Damage model
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Untargeted metabolomic profiling,nutritional composition and enzyme changes on bigeye tuna(Thunnus obesus)during cold storage by UPLC-MS coupled with logistic regression 认领 引用
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作者 Xinyun Wang Zixuan Zhao +1 位作者 Jun Yan Jing Xie 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第7期2811-2821,共11页
Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage,however,there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and... Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage,however,there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and metabolites.This study aimed to investigate how cold storage affects enzyme activities,nutrient composition,tissue microstructures and spoilage metabolites of bigeye tuna.The activities of cathepsins B,H,L increased,while Na+/K+-ATPase and Mg2+-ATPase decreased,α-glucosidase,lipase and lipoxygenase first increased and then decreased during cold storage,suggesting that proteins undergo degradation and ATP metabolism occurs at a faster rate during cold storage.Nutrient composition(moisture and lipid content),total amino acids decreased,suggesting that the nutritional value of bigeye tuna was reduced.Besides,a logistic regression equation has been established as a food analysis tool and assesses the dynamics and correlation of the enzyme of bigeye tuna during cold storage.Based on untargeted metabolomic profiling analysis,a total of 524 metabolites were identified in the bigeye tuna contained several spoilage metabolites involved in lipid metabolism(glycerophosphocholine and choline phosphate),amino acid metabolism(L-histidine,5-deoxy-5′-(methylthio)adenosine,5-methylthioadenosine),carbohydrate metabolism(D-gluconic acid,α-D-fructose 1,6-bisphosphate,D-glyceraldehyde 3-phosphate).The results of tissue microstructures of tuna showed a looser network and visible deterioration of tissue fiber during cold storage.Therefore,metabolomic analysis and tissue microstructures provide insight into the spoilage mechanism investigations on bigeye tuna during cold storage. 展开更多
关键词 Bigeye tuna Enzyme activities Nutrient composition Tissue microstructures Logistic regression Untargeted metabolomic profiling
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