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Maternal depression during pregnancy and children's physical development 认领 引用 被引量：1
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作者 Di Pi Shuifang Lei +20 位作者 Wenjing Chang Cong Liu Yangqian Jiang Yuanyan Dou Jinghan Wang Chang Wang Haowen Zhang Xin Xu Hong Lyu Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Tao Jiang Jiangbo Du Guangfu Jin Hongxia Ma Hongbing Shen Zhibin Hu Kan Ye Yuan Lin 《Journal of Biomedical Research》 CAS CSCD 2026年第1期1-10,共10页
Prenatal maternal psychological distress,particularly depression,has been increasingly recognized as a factor that influences fetal growth;however,its impact on early childhood development remains less well understood... Prenatal maternal psychological distress,particularly depression,has been increasingly recognized as a factor that influences fetal growth;however,its impact on early childhood development remains less well understood.The present study investigated the association between prenatal depression and children's growth trajectories,as well as the odds of overweight and obesity from 1 to 36 months,while also accounting for maternal anxiety and stress.We analyzed data from 4710 mother-child dyads in the Jiangsu Birth Cohort,assessing maternal psychological distress across trimesters and categorizing participants into groups with mild,moderate,and severe depressive symptomatology.Children's weight-for-length z-scores(WLZ)were used to assess overweight/obesity prevalence,and growth patterns were identified through trajectory models.The results from the generalized estimating equations analysis showed that greater depressive symptomatology during pregnancy was associated with a 28%to 41%increase in the odds of childhood overweight/obesity across all three trimesters,compared with mild depressive symptomatology.We identified five distinct WLZ growth trajectory patterns,and found that mothers with greater depressive symptomatology were 39%–47%more likely to have children who followed a very-high-stable growth trajectory,compared with mothers with mild depressive symptomatology.These findings highlight the significant impact of prenatal depression on adverse growth patterns and childhood overweight/obesity,underscoring the need for early intervention. 展开更多
关键词 prenatal distress children overweight and obesity cohort study
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Bxy-glp-1 gene in the Notch pathway regulates the reproductive development of the pine wood nematode 认领 引用
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作者 Quan Li Yuxin Zou +8 位作者 Jing Chen Miao Su Wenjia Jiang Wenyi Liu Jinghan Wang Kai Guo Hudie Shao Liqun Bai Jiafu Hu 《Journal of Forestry Research》 SCIE EI CAS CSCD 2025年第4期215-231,共17页
Studying the reproductive system of the pine wood nematode,Bursaphelenchus xylophilus(Steiner&Buhrer)Nickle,will identify its characteristics and life cycle.This is crucial for developing more targeted control str... Studying the reproductive system of the pine wood nematode,Bursaphelenchus xylophilus(Steiner&Buhrer)Nickle,will identify its characteristics and life cycle.This is crucial for developing more targeted control strategies.In this study,the development of the gonads and reproductive organs were observed using microscopy,gonad dissection,and DAPI staining techniques.Second-stage juveniles(J2)had gonads composed of four primordial germ cells(Z1,Z2,Z3,and Z4)that form the adult gonads by proliferation within 72 h at 25℃.There were subtle differences in somatic gonad cell morphology between males and females,which developed from Z1 and Z4 in third-stage juveniles(J3).These differences became more pronounced at fourth-stage juveniles(J4)and adult stages.Z2 and Z3 germ cells underwent mitosis and two rounds of meiosis,ultimately developing into male and female gametes.Female vulval precursor cells and male cloacal cells developed rapidly during the J4 stage.These results provide a basis for identifying the expression sites and biological functions of key genes regulating reproductive system development.Based on this,in situ hybridization and RNA interference(RNAi)were used to determine the function of the Bxy-glp-1 gene to show that it is involved in vulval formation and spermatogenesis.The results of this study will lay the foundation for disrupting critical stages in the reproduction of B.xylophilus. 展开更多
关键词 Bursaphelenchus xylophilus Reproductive system Gonad Notch Bxy-glp-1
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Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes 认领 引用
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作者 Cong Liu Qun Lu +19 位作者 Qi Xi Shuxin Xiao Jiangbo Du Rui Qin Jinghan Wang Bo Xu Xiumei Han Kun Zhou Shiyao Tao Hong Lv Yangqian Jiang Tao Jiang Kan Ye Guangfu Jin Hongxia Ma Yankai Xia Hongbing Shen Xingyin Liu Yuan Lin Zhibin Hu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第10期1238-1245,共8页
The impact of mother-infant microbiota on neurodevelopment is an area of interest,but longitudinal studies are scarce.Using a cohort of 520 families from the Jiangsu birth cohort in China,we reveal that the maternal g... The impact of mother-infant microbiota on neurodevelopment is an area of interest,but longitudinal studies are scarce.Using a cohort of 520 families from the Jiangsu birth cohort in China,we reveal that the maternal gut microbiota during early pregnancy play a substantial role,accounting for 3.34%of the variance in offspring neurodevelopmental scores.This contribution is notably higher than the 1.24%attributed to the infants’own microbiota at 1 year of age,underscoring the significant influence of maternal gut health on early child development.Remarkably,an elevation in maternal Bifidobacterium pseudocatenulatum is linked to decreased cognitive scores,whereas an enrichment of Bifidobacterium longum at 1 year of age is associated with higher cognitive scores.Furthermore,we find that maternal B.pseudocatenulatum is linked to the heterolactic fermentation metabolic pathway,while infant B.longum is associated with the Bifidobacterium shunt pathway.In summary,our analysis implies that maternal and infant gut microbiota play a distinct role in neurodevelopment,suggesting potential strategies for improving neurodevelopmental outcomes during early pregnancy or infant development by targeting gut microbiota composition. 展开更多
关键词 Gut microbiota Neurodevelopment Bifidobacterium Pregnancy Cohort study
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Realizing high-speed target tracking by using multi-rate feedforward predictive control for the acquisition, tracking, and pointing system 认领 引用
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作者 Hang Li Gaoliang Peng +4 位作者 Xiaobiao Shan Mingyuan Zhao Wei Zhang Jinghan Wang Feng Cheng 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第7期137-151,共15页
The acquisition,tracking,and pointing(ATP)system is widely used in target tracking,counter-UAV operations,and other related fields.As UAV technology develops,there is a growing demand to enhance the tracking capabilit... The acquisition,tracking,and pointing(ATP)system is widely used in target tracking,counter-UAV operations,and other related fields.As UAV technology develops,there is a growing demand to enhance the tracking capabilities of ATP systems.However,in practical applications,ATP systems face various design constraints and functional limitations,making it infeasible to indefinitely improve hardware performance to meet tracking requirements.As a result,tracking algorithms are required to execute increasingly complex tasks.This study introduces a multi-rate feedforward predictive controller to address issues such as low image feedback frequency and significant delays in ATP systems,which lead to tracking jitter,poor tracking performance,low precision,and target loss.At the same time,the pro-posed approach aims to improve the tracking capabilities of ATP systems for high-speed and highly maneuverable targets under conditions of low sampling feedback rates and high feedback delays.The method suggested is also characterized by its low order,fast response,and robustness to model parameter variations.In this study,an actual ATP system is built for target tracking test,and the proposed algorithm is fully validated in terms of simulation and actual system application verification.Results from both simulations and experiments demonstrate that the method effectively compensates for delays and low sampling rates.For targets with relative angular velocities ranging from 0 to 90°/s and angular accelerations between 0 and 470°/s2,the system improved tracking accuracy by 70.0%-89.9%at a sampling frequency of 50 Hz and a delay of 30 m s.Moreover,the compensation algorithm demonstrated consistent performance across actuators with varying characteristics,further confirming its robustness to model insensitivity.In summary,the proposed algorithm considerably enhances the tracking accuracy and capability of ATP systems for high-speed and highly maneuverable targets,reducing the probability of target loss from high speed.This approach offers a practical solution for future multi-target tracking across diverse operational scenarios. 展开更多
关键词 Multi-rate systems Predictive feedforward control Target tracking Laser weapon
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Exploring the Physiological Mechanisms and Clinical Applications of Biofeedback in Emotion Regulation 认领 引用
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作者 Xiaoyan Yang Chengshu Guan +4 位作者 Jinghan Wang Jinting Li Zhihao Lu Jialin Yu Xinling Wu 《Journal of Clinical and Nursing Research》 2025年第7期209-214,共6页
Biofeedback is a behavioral intervention technology based on psychophysiology,which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves t... Biofeedback is a behavioral intervention technology based on psychophysiology,which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves through various ways,so that people can actively change their own physiological changes when they perceive the changes in some physiological functions of their own,and consciously control the physiological functions of various aspects of the autonomic nervous system within a fixed range.It can play a role in improving physical health status,preventing and treating some somatic diseases.Studies have shown that biofeedback relaxation training can make the training subjects learn to regulate their own physiological functions and psychological activities,improve negative emotional states such as depression and anxiety by regulating the body function,and can also be used to assist in the treatment of other clinical diseases.As a new psychological intervention,biofeedback relaxation training has great development potential and can be better applied to the prevention and treatment of physical and mental diseases in the general population in the future. 展开更多
关键词 Biofeedback Physiological mechanism Clinical application
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Quantitative analysis on photon numbers received per cell for triggering β-carotene accumulation in Dunaliella salina 认领 引用
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作者 Yimei Xi Song Xue +2 位作者 Xupeng Cao Zhanyou Chi Jinghan Wang 《Bioresources and Bioprocessing》 SCIE EI 2021年第1期465-475,共11页
Accumulation of β-carotene in Dunaliella salina is highly dependent on light exposure intensity and duration,but quantitative analysis on photon numbers received per cell for triggering β-carotene accumulation is no... Accumulation of β-carotene in Dunaliella salina is highly dependent on light exposure intensity and duration,but quantitative analysis on photon numbers received per cell for triggering β-carotene accumulation is not available so far.In this study,experiment results showed that significant β-carotene accumulation occurred after at least 8 h illumination at 400 µmol photons·m-2·s-1.To quantify the average number of photons received per cell,correlations of light attenuation with light path,biomass concentration,and β-carotene content were,respectively,established using both Lambert-Beer and Cornet models,and the latter provided better simulation.Using Cornet model,average number of photons received per cell (APRPC) was calculated and proposed as a parameter for β-carotene accumulation,and constant APRPC was maintained by adjusting average irradiance based on cell concentration and carotenoids content changes during the whole induction period.It was found that once APRPC reached 0.7 µmol photons cell-1,β-carotene accumulation was triggered,and it was saturated at 9.9 µmol photons cell-1.This study showed that APRPC can be used as an important parameter to precisely simulate and control β-carotene production by D.salina. 展开更多
关键词 β-carotene Average irradiance D.salina Photons received per cell
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Molecular characterization and functional analysis of daf-8 in the pinewood nematode,Bursaphelenchus xylophilus 认领 引用 被引量：1
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作者 Jinghan Wang Huan Hong +7 位作者 Rong Xie Jingjing Ji Kai Guo Liqun Bai Jia Tang Hongshi Yu Jianren Ye Jiafu Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2022年第2期689-698,共10页
Bursaphelenchus xylophilus,causal agent of pine wilt disease,causes extensive damage worldwide.Strate-gies are needed to inhibit population growth or block the spread of the invasive nematode to control pine wilt dis-... Bursaphelenchus xylophilus,causal agent of pine wilt disease,causes extensive damage worldwide.Strate-gies are needed to inhibit population growth or block the spread of the invasive nematode to control pine wilt dis-ease.The gene daf-8 plays crucial roles in larval develop-ment and dauer formation in Caenorhabditis elegans,but little is known about its orthologue in B.xylophilus.In the present molecular characterization and functional analysis of daf-8 in B.xylophilus(Bx-daf-8),RT-qPCR showed that the expression of Bx-daf-8 gradually increased during the embryonic stage,peaked in the second-stage juvenile(J2),then dramatically dropped in the J3,and remained at that low level for the rest of its life.Bx-daf-8-transgenic C.elegans was employed to mimic the spatiotemporal expression of Bx-daf-8,which was expressed close to the pharynx during early embryogenesis and weakly throughout the whole body during late embryogenesis.It was observed in head neurons and tail ganglions throughout all postembryonic stages.B.xylophilus embryos were severely abnormal,and hatching rate decreased sharply after Bx-daf-8 knockdown.daf-16-1 and da-f16-2,downstream genes in the IIS pathway,also dropped sharply after Bx-daf-8 knockdown.We propose that TGFβmay crosstalk with the IIS pathway upstream of Bx-daf-16 and that daf-8 may act as a master regulator of daf-16 in B.xylophilus.However,knockdown of Bx-daf-8 did not lead to constitutive developmental arrest at the dauer larval stage,indicating that dauer entry in B.xylophilus might be controlled by several genes and is more complicated than in C.elegans.Bx-daf-8 alone did not control the dauer entry in B.xylophilus,but it was indispensable for embryogen-esis,providing a potential target for suppressing population growth of B.xylophilus. 展开更多
关键词 Daf-8 Expression pattern RNAi Embryogenesis Bursaphelenchus xylophilus
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Correction to:Molecular characterization and functional analysis of daf-8 in the pinewood nematode,Bursaphelenchus xylophilus 认领 引用
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作者 Jinghan Wang Huan Hong +7 位作者 Rong Xie Jingjing Ji Kai Guo Liqun Bai Jia Tang Hongshi Yu Jianren Ye Jiafu Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第5期1651-1651,共1页
Correction to:J.For.Res.(2022)33:689–698 http://gffzzd3cc09b8251d45dfsx5opfo0x5u9f6bxu.ffgz.tsg.suse.edu.cn/10.1007/s11676-021-01335-7 In the Original Publication,the text“Acknowledgements sdfkjds”has been inadvertently appeared in the paper.The Original article ha... Correction to:J.For.Res.(2022)33:689–698 http://gffzzd3cc09b8251d45dfsx5opfo0x5u9f6bxu.ffgz.tsg.suse.edu.cn/10.1007/s11676-021-01335-7 In the Original Publication,the text“Acknowledgements sdfkjds”has been inadvertently appeared in the paper.The Original article has been corrected. 展开更多
关键词 knowledge characterization functional
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The lactate/PSMD4/glycolysis feedback loop drives chemoresistance and immunosuppression in gallbladder cancer 认领 引用 被引量：1
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作者 Daimin Xiang Yubei Gu +3 位作者 Pinghua Yang Jinghan Wang Hengyu Li Xianglin Liu 《Science Bulletin》 SCIE EI CAS CSCD 2026年第7期1627-1631,共5页
Gallbladder cancer(GBC)accounts for approximately one-third of all biliary system tumors and is one of the most aggressive and lethal malignancies[1].Combination chemotherapy and immunotherapy are the first-line treat... Gallbladder cancer(GBC)accounts for approximately one-third of all biliary system tumors and is one of the most aggressive and lethal malignancies[1].Combination chemotherapy and immunotherapy are the first-line treatments for patients with GBC who are not eligible for surgery,while the treatment outcome was not satisfactory[2].The 26S proteasome non-ATPase regulatory subunit 4(PSMD4)is a ubiquitin receptor subunit of the 26S proteasome[3]. 展开更多
关键词 ubiquitin receptor subunit chemoresistance biliary system tumors glycolysis malignancies combination chemotherapy psmd gallbladder cancer gbc accounts lactate
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The clinical efficacy of traditional Chinese medicine in the auxiliary treatment of grade 1 hypertension: A systematic review and metaanalysis 认领 引用
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作者 Jinghan Wang Zhen Hua +1 位作者 Chao Li Yunlun Li 《TMR Modern Herbal Medicine》 CAS 2021年第4期35-43,共9页
Objective:To systematically evaluate the clinical efficacy of traditional Chinese medicine(TCM)in auxiliary treatment of grade 1 hypertension.Methods:The China National Knowledge Infrastructure,Wan Fang Data,VIP,PubMe... Objective:To systematically evaluate the clinical efficacy of traditional Chinese medicine(TCM)in auxiliary treatment of grade 1 hypertension.Methods:The China National Knowledge Infrastructure,Wan Fang Data,VIP,PubMed were searched to screen the literature of randomized controlled trials of TCM or non-drug therapies assisting conventional medicine to treat grade 1 hypertension.The search time was from the establishment of the database to October 1,2020.Revman5.3 was used for meta-analysis.Results:8 Chinese literatures were included.The results of the study showed that 24h diastolic blood pressure(DBP),24h systolic blood pressure(SBP),DBP lowering effect and TCM syndrome curative efficacy of the experimental group using TCM was better than that of the control group.However,TCM combined conventional medicine did not show an advantage on SBP lowering effect,antihypertensive efficacy rate and total clinical efficacy rate.Conclusion:TCM has a significant effect on lowering blood pressure for adjuvant treatment of grade 1 hypertension and can significantly improve clinical symptoms. 展开更多
关键词 Grade 1 hypertension Traditional Chinese medicine Meta-analysis Systematic review,Effectiveness
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Transition from isotropic to polar state of self-driven eccentric disks 认领 引用
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作者 王静晗 许天亮 +2 位作者 何景熙 陈康 田文得 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期296-302,共7页
Inspired by the eccentricity design of self-driven disks,we propose a computational model to study the remarkable behavior of this kind of active matter via Langevin dynamics simulations.We pay attention to the effect... Inspired by the eccentricity design of self-driven disks,we propose a computational model to study the remarkable behavior of this kind of active matter via Langevin dynamics simulations.We pay attention to the effect of rotational friction coefficient and rotational noise on the phase behavior.A homogeneous system without rotational noise exhibits a sharp discontinuous transition of orientational order from an isotropic to a polar state with the increase of rotational friction coefficient.When there is rotational noise,the transition becomes continuous.The formation of polar state originates from the effective alignment effect due to the mutual coupling of the positional and orientational degrees of freedom of each disk.The rotational noise could weaken the alignment effect and cause the large spatial density inhomogeneity,while the translational noise homogenizes the system.Our model makes further conceptual progress on how the microscopic interaction among self-driven agents yields effective alignment. 展开更多
关键词 eccentric disk Langevin dynamics polar order alignment effect
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Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing 认领 引用 被引量：6
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作者 Ziyi Wang Li Gao +19 位作者 Ziheng Jia Liguo Liu Ao Gu Zhaonan Liu Qin Zhu Yichen Zuo Mingjie Yang Shijia Wang Jiyao Ma Jingyun Zhang Shimei Qiu Zhizhen Li Jinghan Wang Dongxi Xiang Fatao Liu Rong Shao Yanjing Li Maolan Li Wu Wei Yingbin Liu 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2025年第3期1630-1642,共13页
Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression.Here,we employed the advanced long-read full-length transcriptome sequencing on gallb... Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression.Here,we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues,tumors,and cell lines to establish a comprehensive full-length gallbladder transcriptomic atlas.It is of note that receptor tyrosine kinases were one of the most dynamic components with highly variable transcript,with Erb-B2 receptor tyrosine kinase 2(ERBB2)as a prime representative.A novel transcript,designated ERBB2 i14e,was identified for encoding a novel functional protein,and its protein expression was elevated in gallbladder cancer and strongly associated with worse prognosis.With the regulation of splicing factors ESRP1/2,ERBB2 i14e was alternatively spliced from intron 14 and the encoded i14e peptide was proved to facilitate the interaction with ERBB3 and downstream signaling activation of AKT.ERBB2 i14e was inducible and its expression attenuated anti-ERBB2 treatment efficacy in tumor xenografts.Further studies with patient derived xenografts models validated that ERBB2 i14e blockage with antisense oligonucleotide enhanced the tumor sensitivity to trastuzumab and its drug conjugates.Overall,this study provides a gallbladder specific long-read transcriptome profile and discovers a novel mechanism of trastuzumab resistance,thus ultimately devising strategies to improve trastuzumab therapy. 展开更多
关键词 aberrant rna alternative splicing gallbladder cancer ERBB alternative splicing receptor tyrosine kinases long read transcriptome sequencing cell lines RNA alternative splicing trastuzumab resistance
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Synergistic role of deep eutectic solvents in improving engineered chitinase activity for insoluble chitin hydrolysis 认领 引用
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作者 Xiao Chen Li Pang +4 位作者 Wentao Yang Hong Tian Jinghan Wang Liang Yang Bo Xia 《Food Bioscience》 SCIE 2025年第3期279-286,共8页
Chitin,the second most abundant biopolymer on Earth,poses significant hydrolysis challenges due to its intrinsic insolubility and the stringent conditions required for its conversion to chitin oligosaccharides(COSs),w... Chitin,the second most abundant biopolymer on Earth,poses significant hydrolysis challenges due to its intrinsic insolubility and the stringent conditions required for its conversion to chitin oligosaccharides(COSs),which hold considerable industrial and biomedical potential.This study pioneers the use of deep eutectic solvents(DESs)to enhance the hydrolysis of chitin by the engineered chitinase PoChi-FnIII-ChBD(PCFC)from Penicillium oxalicum.DES,composed of hydrogen bond donors and acceptors,are noted for their low toxicity,biodegradability,and ease of preparation.Specifically,a DES synthesized from choline chloride and thiourea(ChCl-THU)significantly improved the efficiency and stability of PCFC.Under optimal conditions(40℃,pH 5.5),PCFC’s activity in 5 vol%ChCl-THU increased by 29.25%,with a 1.68-fold increase in thermal stability and a specific activity of 19.96 U/mg against insoluble chitin.This integrated approach combines chitin solubilization with enzymatic conversion,streamlining industrial processes and demonstrating DESs as sustainable media for enhanced COSs production. 展开更多
关键词 Deep eutectic solvents Engineered chitinase Enzymatic hydrolysis Enzyme stability Insoluble chitin
Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells 认领 引用 被引量：9
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作者 Zhenli Hu Ruohua Chen +8 位作者 Zhijian Cai Lei Yu Yang Fei Lixia Weng Jinghan Wang Xiahui Ge Tianyi Zhu Jianli Wang Chong Bai 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2012年第3期267-275,共9页
Salmeterol is a long-acting β2-agonist that activates adenylate cyclase, causing long-lasting bronchodilation and has been used for many years to control asthma. However, little information is available about the imm... Salmeterol is a long-acting β2-agonist that activates adenylate cyclase, causing long-lasting bronchodilation and has been used for many years to control asthma. However, little information is available about the immunoregulatory effects of salmeterol. We found that salmeterol decreases the production of pro-inflammatory cytokines in a model of allergen-challenged mice that expressed tumor-necrosis factor-alpha, interleukin-1 and interleukin-6. Dendritic cells （DCs） are antigen-presenting cells and act as sentinels in the airway. We found that salmeterol （10-s mol/I） reduced the inflammation caused by lipopolysaccharide （0.1 pg/ml） in activated murine bone marrow-derived DCs. Moreover, western blots demonstrated that this protective effect was mediated partially by inhibiting signaling through the nuclear factor-kappa B （NF-κB）, mitogen-activated protein kinase （MAPK） pathways and dramatically decreased levels of p-ERK. We suggest that salmeterol regulates the inflammation of allergen-induced asthma by modulating DCs. In conclusion, we provide evidence that DCs are the target immune cells responsible for the action of salmeterol against asthma. 展开更多
关键词 asthma dendritic cells pro-inflammatory cytokines salmeterol
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Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China 认领 引用 被引量：5
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作者 Huanping Wang Haitao Meng +8 位作者 Jinghan Wang Yinjun Lou Yile Zhou Peipei Lin Fenglin Li Lin Liu Huan Xu Min Yang Jie Jin 《Frontiers of Medicine》 SCIE CSCD 2020年第3期327-334,F0004,共8页
This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 pat... This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments. 展开更多
关键词 1p32.3 deletion 1q21 gain prognosis multiple myeloma FISH bortezomib thalidomide
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ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification 认领 引用 被引量：4
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作者 Wenle Ye Jinghan Wang +13 位作者 Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang Jiajia Pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin 《Frontiers of Medicine》 SCIE CSCD 2023年第4期685-698,共14页
Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5... Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon cancers.However,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy donors.ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients.In AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in vivo.Mechanistically,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of Wnt3a.Additionally,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML therapy.Our results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML. 展开更多
关键词 acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199
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Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy 认领 引用 被引量：3
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作者 Jinghan Wang Shanqing Gao +4 位作者 Xiao Wang Haozhen Zhang Xitong Ren Juewen Liu Feng Bai 《Nano Research》 SCIE EI CSCD 2022年第3期2347-2354,共8页
The use of functional nanoparticles as peroxidase-like(POD-like)catalyst has recently become a focus of research in cancer therapy.Phthalocyanine is a macrocyclic conjugated metal ligand,which is expected to achieve a... The use of functional nanoparticles as peroxidase-like(POD-like)catalyst has recently become a focus of research in cancer therapy.Phthalocyanine is a macrocyclic conjugated metal ligand,which is expected to achieve a high POD-like catalytic activity,generating free radicals and inhibiting the proliferation of cancer cells.In this paper,we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets,and manganese phthalocyanine(MnPc)possessing a metal–N–C active center was used as the building block.These nano-assemblies exhibit shape-dependent POD-like catalytic activities,because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites.The assembly had a water-dispersed nanostructure,which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect(EPR).Because of a highly efficient microenvironmental response,the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment,but caused less damage to normal tissues in biomedical applications.In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects.This work explored a new way for the application of metal–organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy. 展开更多
关键词 self-assembly manganese phthalocyanine nanozymes peroxidase catalytic therapy
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Morphology-controlled porphyrin nanocrystals with enhanced photocatalytic hydrogen production 认领 引用 被引量：3
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作者 Ronghui Cao Jinghan Wang +2 位作者 Yusen Li Jiajie Sun Feng Bai 《Nano Research》 SCIE EI CSCD 2022年第6期5719-5725,共7页
Molecular self-assembly is a natured-inspired strategy to integrate individual functional molecules into supramolecular nanostructured materials through noncovalent bond interactions for solar to fuel conversion.Howev... Molecular self-assembly is a natured-inspired strategy to integrate individual functional molecules into supramolecular nanostructured materials through noncovalent bond interactions for solar to fuel conversion.However,the design and engineering of the morphology,size,and orderly stacking of supramolecular nanostructures remain a great challenge.In this study,regular porphyrin nanocrystals with different orderly stacked structures are synthesized through noncovalent self-assembly of Pt(II)meso-tetra(4-carboxyphenyl)porphine(PtTCPP),using surfactants with different electronegativity.The synergy of noncovalent bond interactions between porphyrin molecules,and between porphyrin molecules and surfactants resulted in different molecular packing patterns.Due to the spatial ordering of PtTCPP molecules,the different nanocrystals exhibit both collective optical properties and morphology-dependent activities in photocatalytic hydrogen production.The measurements of the photodeposition of dual cocatalysts showed that the photogenerated electrons and holes selectively aggregated at different active sites,revealing separation pathways and directional transfer of photogenerated electrons and holes in the assemblies.This study provides a new strategy to exert rational control over porphyrin self-assembly nanocrystals for highly efficient water splitting. 展开更多
关键词 porphyrin self-assembly morphology-dependent photocatalytic activity directional transfer photogenerated electrons and holes
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Proteomic Portrait of Human Lymphoma Reveals Protein Molecular Fingerprint of Disease Specific Subtypes and Progression 认领 引用 被引量：2
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作者 Xin Ku Jinghan Wang +9 位作者 Haikuo Li Chen Meng Fang Yu Wenjuan Yu Zhongqi Li Ziqi Zhou Can Zhang Ying Hua Wei Yan Jie Jin 《Phenomics》 2023年第2期148-166,共19页
An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders.Current clinical biomarkers for histological classification of lymphomas have encou... An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders.Current clinical biomarkers for histological classification of lymphomas have encountered many discrepancies,particularly for borderline cases.Therefore,we launched a comprehensive proteomic study aimed to establish a proteomic landscape of patients with various lymphatic disorders and identify proteomic variations associated with different disease subgroups.In this study,109 fresh-frozen lymph node tissues from patients with various lymphatic disorders(with a focus on Non-Hodgkin’s Lymphoma)were analyzed by data-independent acquisition mass spectrometry.A quantitative proteomic landscape was comprehensively characterized,leading to the identification of featured protein profiles for each subgroup.Potential correlations between clinical outcomes and expression profiles of signature proteins were also probed.Two representative signature proteins,phospholipid-binding proteins Annexin A6(ANXA6)and Phospholipase C Gamma 2(PLCG2),were successfully validated via immunohistochemistry.We also evaluated the capability of acquired proteomic signatures to segregate multiple lymphatic abnormalities and identified several core signature proteins,such as Sialic Acid Binding Ig Like Lectin 1(SIGLEC1)and GTPase of immunity-associated protein 5(GIMAP5).In summary,the established lympho-specific data resource provides a comprehensive map of protein expression in lymph nodes during multiple disease states,thus extending the existing human tissue proteome atlas.Our findings will be of great value in exploring protein expression and regulation underlying lymphatic malignancies,while also providing novel protein candidates to classify various lymphomas for more precise medical practice. 展开更多
关键词 Lymphoma Non-Hodgkin’s Lymphoma Proteomics Stratification Molecular profiling
Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways 认领 引用
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作者 Qi Guo Linghui Tan +4 位作者 Jiajia Pan Songfang Wu Jiansong Huang Fang Yu Jinghan Wang 《Genes & Diseases》 SCIE CSCD 2023年第2期385-388,共4页
The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failur... The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failure. Recently, three of new beta-coronaviruses have emerged to cause serious and widespread illness and death, such as the Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV), Middle East Respiratory Syndrome Coronaviruses (MERS-CoV), and 2019-nCoV (the causative pathogen of Coronavirus Disease 2019 (COVID-19). The COVID-19 is continuing to spread globally. However, the detailed molecular mechanisms have not yet been fully clarified. Since the similarity of the pathological features among 2019-nCoV, SARS-CoV and MERS-CoV, we could speculate the biological features of current COVID-19 by researching those of MERS-CoV and SARS-CoV. Therefore, we analyzed expression levels of miRNA and mRNA profiles of MERS-CoV, SARS-CoV and 2019-nCoV from five public GEO datasets (Table S1). As a result, we found 16 miRNAs potentially target a group of hub genes clustering together to tune the immune response. Notably, viral RNAs have the ability to sponge miR-500a-5p and miR-501-5p, indicating viral RNAs sequestering these two miRNAs to trigger genes expression and contribute to pathogenesis. We hope this study will pave the way to better understand 2019-nCoV pathogenesis and develop the innovative therapeutics. 展开更多
关键词 miR organs sponge
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