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Cancer stem cells in hepatocellular carcinoma:platforms,updates,challenges and future perspectives 认领 引用 被引量：1
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作者 Jingyi Lu Diana Chui-Yee O +1 位作者 Yu-Man Tsui Irene Oi-Lin Ng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第1期1-7,共7页
Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-... Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-year survival rate is low with a high propensity for recurrence and metastasis1.This clinical challenge in treating HCC is largely attributed to the heterogeneity and intrinsic therapy resistance of cancer stem cells(CSCs),which are a subpopulation of cells with self-renewal capability and multidirectional differentiation potential to induce tumorigenicity2.The behavior and maintenance of CSCs are not autonomous but critically dependent on the complex bidirectional crosstalk between CSCs and the tumor immune microenvironment(TIME)1.In this review we first summarize the recent progress in characterizing CSCs and the interactions between CSCs and the TIME in HCC.Next,we discuss the emerging therapeutic strategies targeting CSC populations with the ongoing challenges.Finally,we give our perspectives on the future directions in HCC CSC research. 展开更多
关键词 future perspectives hepatocellular carcinoma cancer stem cells cscs which cancer stem cells challenges therapeutic strategies hepatocellular carcinoma hcc tumor immune microenvironment
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Occupational Burnout and Depressive Symptoms among Resident Physicians at Shanghai Tenth People’s Hospital in the Early Post-COVID-19 Period:A Cross-Sectional Study 认领 引用
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作者 Zhui Ke Jie Gao +4 位作者 Yini Zhao Jingyi Lu Xinpei Luo Xuemin He Jin Li 《Asia Pacific Journal of Clinical Medical Research》 2026年第3期31-38,共8页
Background:Resident physicians may experience persistent occupational and psychological strain during the early post-COVID-19 period.Burnout and depressive symptoms can overlap,but they represent diff erent aspects of... Background:Resident physicians may experience persistent occupational and psychological strain during the early post-COVID-19 period.Burnout and depressive symptoms can overlap,but they represent diff erent aspects of psychological burden and should be assessed using standardized instruments.Objective:To estimate the prevalence of occupational burnout and SDS-defined depressive symptoms among resident physicians undergoing standardized residency training at Shanghai Tenth People’s Hospital and to examine the association between burnout scores and depressive-symptom severity.Methods:This single-center cross-sectional anonymous questionnaire study was conducted at Shanghai Tenth People’s Hospital,Shanghai,China,from January to June 2023.A total of 132 eligible resident physicians were invited through hospital residency-training coordination,and all 132 returned questionnaires(response rate,100.0%).Occupational burnout was assessed using a Chinese burnout questionnaire structured around the MBI-GS dimensions,and depressive symptoms were assessed using the validated Chinese Self-Rating Depression Scale(SDS).Internal consistency was assessed using Cronbach’s alpha.Prevalence estimates were reported with Wilson 95%confi dence intervals(CIs).Pearson correlation and multivariable linear regression were used to examine the association between burnout score and SDS standard score.Results:Overall,102/132(77.3%;95%CI,69.4 to 83.6)residents met the predefined burnout criterion.In complete valid SDS responses,81/124(65.3%;95%CI,56.6 to 73.1)residents had SDS-defi ned depressive symptoms.Cronbach’s alpha was 0.887 for the burnout questionnaire and 0.861 for the SDS.Burnout score was positively correlated with SDS standard score(n=124;r=0.64,95%CI,0.52 to 0.73;p<0.001).In multivariable linear regression,burnout score remained positively associated with SDS standard score after adjustment for sex,age group,training duration,and grouped specialty(adjusted beta=0.35,95%CI,0.27 to 0.44;p<0.001).Conclusions:Occupational burnout and SDS-defined depressive symptoms were common among resident physicians at Shanghai Tenth People’s Hospital in the early post-COVID-19 period.The fi ndings suggest that routine screening,workload management,mentorship,and accessible psychological support may be useful for residents at risk.Because this was a cross-sectional study,causality cannot be inferred. 展开更多
关键词 COVID-19 Burnout Depressive Symptoms Resident Physicians Mental Health Standardized Residency Training
Fully flexible wearable pouch pneumatic artificial muscle based on asymmetric expansion 认领 引用
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作者 Jingyi Lu Xiaosen Lv +2 位作者 Jianbin Liu Haitao Liu Tian Huang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第2期137-144,共8页
Pneumatic artificial muscle(PAM) is the core actuating component in wearable devices and soft robots.It typically incorporates rigid elements to enhance actuation performance,leading to reduced wear comfort and even a... Pneumatic artificial muscle(PAM) is the core actuating component in wearable devices and soft robots.It typically incorporates rigid elements to enhance actuation performance,leading to reduced wear comfort and even additional energy metabolism.Additionally,the significant radial expansion of the PAM can lead to it compressing against the human body.This paper introduces a fully flexible wearable pouch pneumatic artificial muscle based on asymmetric expansion(AEPAM).Using a weaving structure,the expansion center of the airbag is offset from the traction axis,resulting in the AEPAM exhibiting radial asymmetric expansion.At a low air pressure of 70 kPa,it achieves a contraction rate of 51.09% and a contraction force of 243.94 N.When the load is increased to 5 kg,the contraction rate of AEPAM can still reach 29.69%.The AEPAM unit is exceptionally lightweight,weighing only 9.04 g,with a contraction force-to-weight ratio of approximately 27100 N/kg.In the extrusion force experiment,AEPAM maintains the wear-side extrusion force within 10N,effectively avoiding additional compression produced when the wearable actuator operates,achieving an 89.61% reduction compared to the rectangular pouch PAM.Finally,preliminary testing confirms that the muscle activation of the biceps can be reduced by 41.82% during unloaded elbow flexion movements.When carrying a 3 kg load,the muscle activation is reduced by 33.64%. 展开更多
关键词 Pneumatic artificial muscle Soft actuator Asymmetric expansion Woven structure Wearable robot
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A Perspective on Artificial Intelligence for Process Manufacturing 认领 引用 被引量：1
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作者 Vipul Mann Jingyi Lu +1 位作者 Venkat Venkatasubramanian Rafiqul Gani 《Engineering》 SCIE EI CSCD 2025年第9期60-67,共8页
To achieve sustainable development goals and the requirements of a circular economy,a new class of intelligent computer-aided methods and tools is needed.Artificial intelligence(AI)techniques have been gaining much at... To achieve sustainable development goals and the requirements of a circular economy,a new class of intelligent computer-aided methods and tools is needed.Artificial intelligence(AI)techniques have been gaining much attention due to their ability to provide options to tackle the challenges we are currently facing.However,the successful application of AI to solve problems of current interest requires AI to be integrated with associated process systems engineering methods and tools that are already available or being developed.In this perspective paper,we highlight the use of a collection of process systems engineering methods and tools augmented by AI techniques to solve problems related to process manufacturing,with a focus on chemical product design,process synthesis and design,process control,and process safety and hazards. 展开更多
关键词 Artificial intelligence Machine learning Process systems engineering Manufacturing
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MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment 认领 引用 被引量：5
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作者 Jiakang Yang Jing Shuai +6 位作者 Lixuen Siow Jingyi Lu Miao Sun Wenyue An Mengfei Yu Baixiang Wang Qianming Chen 《Bone Research》 SCIE CAS CSCD 2024年第1期153-164,共12页
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge,as chronic local inflammation can largely impair bone healing.Here,we used magnesium silicate nanos... Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge,as chronic local inflammation can largely impair bone healing.Here,we used magnesium silicate nanospheres(MSNs)to load microRNA-146a-5p(miR-146a)to fabricate a nanobiomaterial,MSN+miR-146a,which showed synergistic promoting effects on the osteogenic differentiation of human dental pulp stem cells(hDPSCs).In addition,miR-146a exhibited an anti-inflammatory effect on mouse bone marrow-derived macrophages(BMMs)under lipopolysaccharide(LPS)stimulation by inhibiting the NF-κB pathway via targeting tumor necrosis factor receptor-associated factor 6(TRAF6),and MSNs could simultaneously promote M2 polarization of BMMs.MiR-146a was also found to inhibit osteoclast formation.Finally,the dual osteogenic-promoting and immunoregulatory effects of MSN+miR-146a were further validated in a stimulated infected mouse mandibular bone defect model via delivery by a photocuring hydrogel.Collectively,the MSN+miR-146a complex revealed good potential in treating inflammatory irregular oralmaxillofacial bone defects. 展开更多
关键词 inflammatory healing stimulation
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Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration 认领 引用 被引量：2
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作者 Jingyi Lu Miao Sun +7 位作者 Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2023年第5期507-521,共15页
Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts.Here,we propose a novel st... Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts.Here,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects.Loose and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their biosafety.The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus.After internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium ions.Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications. 展开更多
关键词 Nanoparticles Benidipine Bone tissueengineering Endocytosis
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High Water Resistance and Enhanced Mechanical Properties of Bio-Based Waterborne Polyurethane Enabled by in-situ Construction of Interpenetrating Polymer Network 认领 引用 被引量：1
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作者 Henghui Deng Jingyi Lu +5 位作者 Dunsheng Liang Xiaomin Wang Tongyao Wang Weihao Zhang Jing Wang Chaoqun Zhang 《Journal of Renewable Materials》 SCIE EI CAS 2023年第3期1209-1222,共14页
In this study,acrylic acid was used as a neutralizer to prepare bio-based WPU with an interpenetrating polymer network structure by thermally induced free radical emulsion polymerization.The effects of the content of ... In this study,acrylic acid was used as a neutralizer to prepare bio-based WPU with an interpenetrating polymer network structure by thermally induced free radical emulsion polymerization.The effects of the content of acrylic acid on the properties of the resulting waterborne polyurethane-poly(acrylic acid)(WPU-PAA)dispersion and the films were systematically investigated.The results showed that the cross-linking density of the interpenetrating network polymers was increased and the interlocking structure of the soft and hard phase dislocations in the molecular segments of the double networks was tailored with increasing the content of acrylic acid,leading to enhancement of the mechanical properties and water resistance of WPU-PAA films.Notably,with the increase in content of acrylic acid,the tensile strength,Young’s modulus,and toughness of the WPU-PAA-110 film increased by 3 times,and 8 times,and 2.4 times compared with WPU-PAA-80,respectively.The WPU-PAA-100 film showed the best water resistance,and the water absorption rate at 96 h was only 3.27%.This work provided a new design scheme for constructing bio-based WPU materials with excellent properties. 展开更多
关键词 Bio-based waterborne polyurethane interpenetrating polymer network highly water resistance superior mechanical performance
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A local space transfer learning-based parallel Bayesian optimization with its application 认领 引用 被引量：1
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作者 Luhang Yang Xixiang Zhang +2 位作者 Jingyi Lu Zhou Tian Wenli Du 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第10期227-237,共11页
The optimization of process parameters in polyolefin production can bring significant economic benefits to the factory.However,due to small data sets,high costs associated with parameter verification cycles,and diffic... The optimization of process parameters in polyolefin production can bring significant economic benefits to the factory.However,due to small data sets,high costs associated with parameter verification cycles,and difficulty in establishing an optimization model,the optimization process is often restricted.To address this issue,we propose using a transfer learning Bayesian optimization strategy to improve the efficiency of parameter optimization while minimizing resource consumption.Specifically,we leverage Gaussian process(GP)regression models to establish an integrated model that incorporates both source and target grade production task data.We then measure the similarity weights of each model by comparing their predicted trends,and utilize these weights to accelerate the solution of optimal process parameters for producing target polyolefin grades.In order to enhance the accuracy of our approach,we acknowledge that measuring similarity in a global search space may not effectively capture local similarity characteristics.Therefore,we propose a novel method for transfer learning optimization that operates within a local space(LSTL-PBO).This method employs partial data acquired through random sampling from the target task data and utilizes Bayesian optimization techniques for model establishment.By focusing on a local search space,we aim to better discern and leverage the inherent similarities between source tasks and the target task.Additionally,we incorporate a parallel concept into our method to address multiple local search spaces simultaneously.By doing so,we can explore different regions of the parameter space in parallel,thereby increasing the chances of finding optimal process parameters.This localized approach allows us to improve the precision and effectiveness of our optimization process.The performance of our method is validated through experiments on benchmark problems,and we discuss the sensitivity of its hyperparameters.The results show that our proposed method can significantly improve the efficiency of process parameter optimization,reduce the dependence on source tasks,and enhance the method's robustness.This has great potential for optimizing processes in industrial environments. 展开更多
关键词 Transfer learning Bayesian optimization Process parameters Parallel framework Local search space
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Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation 认领 引用 被引量：6
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作者 Cheng Li Xiaojing Ma +7 位作者 Jingyi Lu Rui Tao Xia Yu Yifei Mo Wei Lu Yuqian Bao Jian Zhou Weiping Jia 《Frontiers of Medicine》 SCIE CSCD 2023年第1期68-74,共7页
Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parame... Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk.As a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose dynamics.By calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis. 展开更多
关键词 complexity of glucose time series continuous glucose monitoring impaired glucose regulation insulin secretion and sensitivity refined composite multi-scale entropy
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Smooth muscle AKG/OXGR1 signaling regulates epididymal fluid acid–base balance and sperm maturation 认领 引用 被引量：1
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作者 Chang Xu Yexian Yuan +12 位作者 Cha Zhang Yuchuan Zhou Jinping Yang Huadong Yi Ishwari Gyawali Jingyi Lu Sile Guo Yunru Ji Chengquan Tan Songbo Wang Yongliang Zhang Qingyan Jiang Gang Shu 《Life Metabolism》 2022年第1期67-80,共14页
Infertility is a global concern attributed to genetic defects,lifestyle,nutrition,and any other factors that affect the local metabolism and niche microenvironment of the reproductive system.2-Oxoglutarate receptor 1(... Infertility is a global concern attributed to genetic defects,lifestyle,nutrition,and any other factors that affect the local metabolism and niche microenvironment of the reproductive system.2-Oxoglutarate receptor 1(OXGR1)is abundantly expressed in the testis;however,its cellular distribution and biological function of OXGR1 in the male reproductive system remain unclear.In the current study,we demonstrated that OXGR1 is primarily expressed in epididymal smooth muscle cells(SMCs).Aging and heat stress significantly reduced OXGR1 expression in the epididymis.Using OXGR1 global knockout and epididymal-specific OXGR1 knockdown models,we revealed that OXGR1 is essential for epididymal sperm maturation and fluid acid–base balance.Supplementation ofα-ketoglutaric acid(AKG),the endogenous ligand of OXGR1,effectively reversed epididymal sperm maturation disorders caused by aging and heat stress.Furthermore,in vitro studies showed that AKG markedly stimulated the release of instantaneous intracellular calcium from epididymal SMCs and substantially reduced the pHi value in the epididymal SMCs via OXGR1.Mechanistically,we discovered that AKG/OXGR1 considerably increased the expression of Na+/HCO3−cotransporter(NBCe1)mRNA in the epididymal SMCs,mediated by intracellular calcium signaling.The local AKG/OXGR1 system changed the epididymal fluid pH value and HCO3−concentration,thereby regulating sperm maturation via intracellular calcium signaling and NBCe1 mRNA expression.This study for the first time reveals the crucial role of OXGR1 in male fertility and sheds light on the applicability of metabolic intermediates in the nutritional intervention of reproduction. 展开更多
关键词 AKG OXGR1 epididymis acid-base balance sperm maturation
The role of exosomes in therapeutic resistance of hepatocellular carcinoma 认领 引用 被引量：1
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作者 Jin Wang Yali Yang +1 位作者 Jingyi Lu Xia Wang 《Hepatoma Research》 CAS 2023年第1期70-86,共17页
Hepatocellular carcinoma(HCC)stands as one of the most prevalent malignant tumors globally.Despite considerable advancements in HCC therapies,therapeutic resistance remains a significant challenge that compromises pat... Hepatocellular carcinoma(HCC)stands as one of the most prevalent malignant tumors globally.Despite considerable advancements in HCC therapies,therapeutic resistance remains a significant challenge that compromises patient prognosis.Increasing evidence indicates that exosomes,which are secreted by cells in the tumor microenvironment(TME),are pivotal players in the development of therapeutic resistance in HCC.These nano-sized vesicles mediate intercellular communication in TME through the transfer of bioactive molecules such as nucleic acids,lipids,and proteins.A comprehensive understanding of the role of exosomes in therapeutic resistance could provide promising strategies for both the diagnosis and treatment of HCC.This review mainly summarizes the involvement of exosomal cargos and elucidates their underlying mechanisms in resistance to therapeutic treatments for HCC,and further discusses the potential clinical applications of exosomes as diagnostic biomarkers and therapeutic targets to overcome drug resistance in HCC. 展开更多
关键词 Hepatocellular carcinoma exosome therapeutic resistance
Association between time in range and cancer mortality among patients with type 2 diabetes:a prospective cohort study 认领 引用 被引量：4
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作者 Yun Shen Chunfang Wang +8 位作者 Yaxin Wang Jingyi Lu Lei Chen Lei Zhang Wei Lu Wei Zhu Gang Hu Tian Xia Jian Zhou 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第3期288-294,共7页
Background:Little was known about the association among time in range(TIR),time above range(TAR),time below range(TBR),and cancer mortality among patients with type 2 diabetes.We aimed to investigate the association a... Background:Little was known about the association among time in range(TIR),time above range(TAR),time below range(TBR),and cancer mortality among patients with type 2 diabetes.We aimed to investigate the association among TIR,TAR,TBR,and the risk of cancer mortality among patients with type 2 diabetes.Methods:A total of 6225 patients with type 2 diabetes were prospectively recruited in Shanghai,China.TIR was measured with continuous glucose monitoring at baseline and was defined as the average percentage of time in the target glucose range during a 24 h period.Cox proportion hazard regression analysis was used to determine the association between TIR and the risk of cancer mortality.Results:During a mean follow-up of 7.10 years,we confirmed 237 death events related to cancer.The multivariable-adjusted hazard ratio(HR)for cancer mortality was 1.32(95%confidence interval[CI]:1.01-1.75)in patients with TIR≤70%compared with those with TIR>70%.When TIR was considered as a continuous variable,the multivariable-adjusted HR for cancer mortality associated with each 10%decrease in TIR was 1.07(95%CI:1.02-1.14).In the site-specific analysis,a significant association between TIR as a continuous variable and the risk of hepatocellular cancer was found(HR:1.24;95%CI:1.09-1.41).However,no relationship between hemoglobin A1c and cancer mortality was observed(HR:1.04;95%CI:0.97-1.10).Conclusions:The present study found an inverse association of TIR with the risk of cancer mortality among patients with type 2 diabetes.New evidence of TIR was added into the clinical practice that TIR may be an optimal target of glycemic control among patients with type 2 diabetes. 展开更多
关键词 Time in range HbA1c Type 2 diabetes Cancer mortality Cohort study Hepatocellular cancer
Insulin resistance and the metabolism of branched-chain amino acids 认领 引用 被引量：7
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作者 Jingyi Lu Guoxiang Xie +1 位作者 Weiping Jia Wei Jia 《Frontiers of Medicine》 SCIE CSCD 2013年第1期53-59,共7页
Insulin resistance(IR)is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders.IR related metabolic disturbance i... Insulin resistance(IR)is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders.IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network.Branched-chain amino acids(BCAAs),namely valine,leucine and isoleucine,are among the nine essential amino acids,accounting for 35%of the essential amino acids in muscle proteins and 40%of the preformed amino acids required by mammals.The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency.Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight,it is only recently that BCAAs are found to be closely associated with IR.This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies. 展开更多
关键词 branched-chain amino acids leucine isoleucine valine insulin resistance
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论游戏发展与科技革命 认领 引用
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作者 周城雄 卢静懿 邓雨龙 《中国数字出版》 2025年第2期1-11,共11页
游戏与科学有诸多共通之处,二者相辅相成、共同进步。一方面,科技进步推动了游戏革命,特别是算力进步成为影像更逼真、机制更复杂的游戏的前提条件;另一方面,游戏提升了人类的认知能力,赋予人类以探索精神、合作精神,为科技革命提供了... 游戏与科学有诸多共通之处,二者相辅相成、共同进步。一方面,科技进步推动了游戏革命,特别是算力进步成为影像更逼真、机制更复杂的游戏的前提条件;另一方面,游戏提升了人类的认知能力,赋予人类以探索精神、合作精神,为科技革命提供了需求与应用场景。当代,游戏已经成为前沿科技的试验场,甚至创造出一个与真实世界相孪生的虚拟世界。行业应把握游戏发展与科技革命之间的客观规律和发展趋势,为虚实共生、人机共存的未来世界奠定坚实基础。 展开更多
关键词 游戏 科技进步 科技革命 游戏史
Metabolomics in human type 2 diabetes research 认领 引用 被引量：1
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作者 Jingyi Lu Guoxiang Xie +1 位作者 Weiping Jia Wei Jia 《Frontiers of Medicine》 SCIE CSCD 2013年第1期4-13,共10页
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society.Although scientific advances have led to effective strategies for preventing and treating diabetes over the pas... The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society.Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades,little progress has been made toward curing the disease or even getting it under control,from a public health and overall societal standpoint.There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses,highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications.The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites,which are sensitive to the changes of both environmental and genetic factors and therefore,could be regarded as the link between genotypes and phenotypes.During the last decade,the progression made in metabolomics has provided insightful information on disease development and disease onset prediction.Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered,including branched-chain and aromatic amino acids,such as isoleucine,leucine,valine,tyrosine and phenylalanine,as diagnostic or highly-significant predictors of future diabetes.This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes,type 2 diabetes. 展开更多
关键词 metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance(NMR)
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Potential modifying effect of grip strength on the association between glycated hemoglobin(HbA1c)and all-cause mortality in older adults with type 2 diabetes:Evidence from UK Biobank 认领 引用
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作者 Jingyi Lu Yaxin Wang +4 位作者 Yun Shen Yifei Mo Xiaojing Ma Gang Hu Jian Zhou 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第12期1501-1503,共3页
To the Editor:Frailty status represents one of the core determinants for the individualization of glycated hemoglobin(HbA1c)targets in the elderly population.However,the most validated tools to quantify frailty,which ... To the Editor:Frailty status represents one of the core determinants for the individualization of glycated hemoglobin(HbA1c)targets in the elderly population.However,the most validated tools to quantify frailty,which are complex and involve multiple dimensions of assessment,are rarely used in the clinical practice of diabetes management.Therefore,a simple and practical metric for the evaluation of frailty is needed.Grip strength is an easily measurable,objective,and reproducible metric for assessing frailty status.[1]It is correlated with overall muscle strength and has been reported to be signicantly related to important health outcomes both in the general population[2,3]and in patients with diabetes.[4]Therefore,grip strength could be a useful marker for patient strati-cation in diabetes management.In this context,this study aimed to examine the associations between HbA1c and all-cause mortality across categories of grip strength,as a measure of frailty status,in older adults with type 2 diabetes in the UK Biobank.The researches had applied to access the UK Biobank database with the application approval number of 82812. 展开更多
关键词 diabetes mortality strength
Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes 认领 引用 被引量：6
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作者 Wejing Zhao Jingyi Lu +4 位作者 Lei Zhang Wei Lu Wei Zhu Yuqian Bao Jjian Zhou 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第16期1978-1985,共8页
Background: Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which... Background: Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which was reported to be associated with diabetic complications. We sought to explore the relationship between TIR and corneal nerve parameters in asymptomatic patients with type 2 diabetes (T2DM).Methods: In this cross-sectional study, 206 asymptomatic inpatients with T2DM were recruited. After 7 days of continuous glucose monitoring, the TIR was calculated as the percentage of time in the glucose range of 3.9 to 10.0 mmol/L. CCM was performed to determine corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length (CNFL). Abnormal CNFL was defined as ≤15.30 mm/mm2.Results: Abnormal CNFL was found in 30.6% (63/206) of asymptomatic subjects. Linear regression analyses revealed that TIR was positively correlated with CCM parameters both in the crude and adjusted models (all P< 0.05). Each 10% increase in TIR was associated with a 28.2% (95% CI: 0.595–0.866,P = 0.001) decreased risk of abnormal CNFL after adjusting for covariates. With the increase of TIR quartiles, corneal nerve fiber parameters increased significantly (allP for trend <0.01). The receiver operating characteristic curve indicated that the optimal cutoff point of TIR was 77.5% for predicting abnormal CNFL in asymptomatic patients.Conclusions: There is a significant independent correlation between TIR and corneal nerve fiber loss in asymptomatic T2DM patients. TIR may be a useful surrogate marker for early diagnosis of DSPN. 展开更多
关键词 Continuous glucose monitoring Corneal confocal microscopy Time in range Type 2 diabetes
Research progress in the application of time in range: more than a percentage 认领 引用 被引量：4
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作者 Jintao Wan Jingyi Lu +2 位作者 Cheng Li Xiaojing Ma Jian Zhou 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第5期522-527,共6页
Glucose monitoring is an important part of medical care in diabetes mellitus,which not only helps assess glycemic control and treatment safety,but also assists with treatment adjustment.With the development of continu... Glucose monitoring is an important part of medical care in diabetes mellitus,which not only helps assess glycemic control and treatment safety,but also assists with treatment adjustment.With the development of continuous glucose monitoring(CGM),the use of CGM has increased rapidly.With the wealth of glucose data produced by CGM,new metrics are greatly needed to optimally evaluate glucose status and guide the treatment.One of the parameters that CGM provides,time in range(TIR),has been recognized as a key metric by the international consensus.Before the adoption of TIR in clinical practice,several issues including the minimum length of CGM use,the setting of the target range,and individualized TIR goals are summarized.Additionally,we discussed the mounting evidence supporting the association between TIR and diabetes-related outcomes.As a novel glucose metric,it is of interest to compare TIR with other conventional glucose markers such as glycated hemoglobin A1c.It is anticipated that the use of TIR may provide further information on the quality of glucose control and lead to improved diabetes management. 展开更多
关键词 Diabetes mellitus Time in range Continuous glucose monitoring
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