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Ability of the Chinese herbal residue to alleviate short-distance transportation stress in sheep through the remodeling of the rumen microbiome–metabolism axis 认领 引用
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作者 Jing Li Jianrong Ren +5 位作者 Jiawen Xu Jinhui He Jingyi Xu Qingyan Yin Junhu Yao Shengru Wu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期2134-2153,共20页
Background Transportation is a common stressor in sheep production that is capable of inducing oxidative stress and impairing sheep health and production performance.This study aimed to investigate the alleviating eff... Background Transportation is a common stressor in sheep production that is capable of inducing oxidative stress and impairing sheep health and production performance.This study aimed to investigate the alleviating effects of the traditional formula Siji Antiviral Mixture residue after water extraction,which still contains active ingredients,including fiber,polyphenols,and flavonoids,on short-distance transport stress in sheep,as well as its mechanism of action in regulating oxidative stress through the rumen microbiota-metabolism axis.Results Twenty first-lambing East Friesian×Hu sheep hybrids weighing 54.49±7.94 kg were randomly assigned to a control group(CON,basal diet)or a Chinese herbal residue group(CMR,basal diet+50 g/d CMR)feeding at 4 h after approximately 300 km of short-distance transport.Results indicated that 4 h of short-distance transport significantly elevated serum reactive oxygen species(ROS)levels in sheep.Supplementation with Chinese herbal medicine residues markedly reduced serum ROS and lactate dehydrogenase levels while increasing glutathione peroxidase and immunoglobulin G levels.Metagenomic results revealed significantly increased abundance of bacteria such as Selenomonas ruminantium in the rumen of the CMR group,along with substantial increases in CAZymes,including AA7,GH113,and GH84.Metabolomic analysis revealed differentially expressed metabolites in plasma and rumen fluid that were enriched in metabolic pathways such as glycerophospholipid metabolism,α-linolenic acid metabolism,and drug metabolism-cytochrome P450.Correlation network analysis further revealed that Selenomonas ruminantium was significantly negatively correlated with ROS and positively correlated with ruminal LysoPC(16:1(9Z)/0:0),plasma phosphatidylcholine,and key glycerophospholipid metabolism enzymes(e.g.,EC 3.1.4.3,PLC).Glycerophospholipid metabolism exhibited synergistic regulatory interactions with arachidonic acid metabolism and drug metabolism-cytochrome P450 pathways.Conclusion This study confirmed that 4 h of short-distance transport can induce oxidative stress in sheep.Supplementing feed with Siji Antiviral Mixture herbal residue effectively alleviated transport stress and enhanced immune function.The mechanism of action involved rumen microbial conversion of the herbal residue,which substantially increased the abundance of Selenomonas ruminantium.Related metabolites then regulated host arachidonic acid metabolism and cytochrome P450 drug metabolism indirectly through the glycerophospholipid metabolic pathway and the rumen microbiota-metabolism axis,thereby synergistically exerting antioxidant effects. 展开更多
关键词 East Friesian×Hu sheep Microbiome–metabolism axis Oxidative stress Short-distance transportation Traditional Chinese medicine residue
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Ruminal‑buccal microbiota transmission and their diagnostic roles in subacute rumen acidosis in dairy goats 认领 引用 被引量：1
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作者 Tao Liu Jingyi Xu +7 位作者 Xiaodong Chen Jianrong Ren Jinhui He Yue Wang Yangchun Cao Le Luo Guan Junhu Yao Shengru Wu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第2期895-912,共18页
Background Subacute rumen acidosis(SARA)is a common metabolic disorder in ruminants that disrupts the rumen microbiome and animal health,but diagnosis is challenging due to subtle symptoms and invasive testing require... Background Subacute rumen acidosis(SARA)is a common metabolic disorder in ruminants that disrupts the rumen microbiome and animal health,but diagnosis is challenging due to subtle symptoms and invasive testing require-ments.This study explores the potential of the buccal(oral)microbiome as a diagnostic indicator for SARA,hypoth-esizing an interaction with the rumen microbiome.Results The study involved 47 dairy goats,including 11 on a control diet and 36 on high-concentrate diets with increasing rumen-degradable starch.Animals were grouped based on dietary exposure and ruminal pH:Control,Low-RDS Tolerance/SARA(LRDST/LRDSS),and High-RDS Tolerance/SARA(HRDST/HRDSS).Transcriptomics of rumen epithelium showed heightened inflammatory pathway gene expression in SARA-susceptible goats compared to controls and tolerant groups.Alpha diversity of ruminal bacteria showed lower Shannon diversity in HRDSS goats compared to HRDST whereas buccal bacteria displayed significantly lower Chao1 diversity in LRDSS goats compared to HRDST.Beta diversity analyses revealed distinct patterns between SARA-affected goats and healthy controls in both ruminal and buccal microbiomes.Prevotellaceae_UCG-003 emerged as a candidate biomarker,with reduced abundance in SARA-susceptible goats in both rumen and buccal samples.Machine learning classifiers achieved high accuracy in distinguishing SARA-susceptible goats using this genus(rumen AUC=0.807;buccal AUC=0.779).Source tracking analysis illustrated diminished cross-population of bacteria from the buccal to rumen(2.86%to 0.25%)and vice versa(8.59%to 1.17%),signifying compromised microbial interchange in SARA-affected goats.A microbiota transplant experiment verified SARA microbiota’s ability to induce pH decline,escalate inflammation-related gene expression(MAPK10,IL17B,FOSB,SPP1),disrupt microbial transfer,and reduce Prevotellaceae_UCG-003 in recipients.Conclusion Our findings highlight SARA’s dual impact on ruminal and buccal microbiota,exacerbating epithelial inflammation gene expression.Shifts in the buccal microbiome,specifically reductions in Prevotellaceae_UCG-003,mirror ruminal changes and can be influenced by inter-compartmental bacterial transmission,thereby offering a non-invasive diagnostic approach for SARA. 展开更多
关键词 Dairy goats Diagnosis Oral microbiota Ruminal microbiota Subacute rumen acidosis
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Metagenomic sequencing reveals high reproducibility of human donor microbiota transplanted into germ-free mice via lower gut route 认领 引用
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作者 Yapeng YANG Xiang TAN +12 位作者 Zeyue ZHANG Lifeng LIANG Zhifeng WU Jinhui HE Yuqing WANG Miaomiao DONG Jixia ZHENG Hang ZHANG Shuaifei FENG Wei CHENG Bota CUI Hong WEI Qinjin LI 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2026年第4期375-389,共15页
Human flora-associated(HFA)mice are often used to simulate the structure of human intestinal microbiota and to study the causal relationships between diseases and gut microbiota.However,several factors affect the colo... Human flora-associated(HFA)mice are often used to simulate the structure of human intestinal microbiota and to study the causal relationships between diseases and gut microbiota.However,several factors affect the colonization efficiency of human microbiota in germ-free(GF)mice,and the differential effects of gavage and lower gut transplantation on colonization are still unclear.In this study,we explored the reproducibility of the recipient-to-donor gut microbiota community structure and function under different transplantation routes and the differences in microbial colonization between recipients via gavage transplantation(GT_mice group)and lower gut transplantation(LGT_mice group).High-throughput sequencing of the metagenome was performed on the feces of each subject,and the composition of microbiome of each group was analyzed.As expected,the introduction of human fecal microbiota into GF mice via lower gut transplantation had a high transfer efficiency,which was evident from the similar species community structure to that of the donor(Adonis R2=0.713960 for LGT_mice group–donor group;Adonis R2=0.774095 for GT_mice group–donor group)and a higher bacterial colonization rate.The findings provide unique insights into improving the accuracy of constructing humanized microbiota transplantation models,aiding our understanding of the relationships between the human gut microbiota and disease. 展开更多
关键词 Fecal microbiota transplantation Germ-free mice Lower gut Gavage Metagenome
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Membranes for extracorporeal membrane oxygenator(ECMO): History,preparation, modification and mass transfer 认领 引用 被引量：10
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作者 Ting He Songhong Yu +7 位作者 Jinhui He Dejian Chen Jie Li Hongjun Hu Xingrui Zhong Yawei Wang Zhaohui Wang Zhaoliang Cui 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2022年第9期46-75,共30页
Extracorporeal membrane oxygenator(ECMO) has been in development for nearly 70 years, and the oxygenator has gone through several generations of optimizations, with advances from bubble oxygenators to membrane oxygena... Extracorporeal membrane oxygenator(ECMO) has been in development for nearly 70 years, and the oxygenator has gone through several generations of optimizations, with advances from bubble oxygenators to membrane oxygenators leading to more and more widespread use of ECMO. Membrane is the core of a ECMO system and the working mechanism of membrane oxygenator depends on the membrane material,from PDMS flat membrane to PMP hollow fiber membrane, which have experienced three generations.Blood compatibility on the surface of the membrane material is very vital, which directly determines the use duration of the oxygenator and can reduce the occurrence of complications. The mechanism of mass transfer is the basis of oxygenator operation and optimization. This review summarizes the membrane development history and preparation technology, modification approaches and mass transfer theory in the process of oxygen and blood exchange. We hoped that this review will provide more ideas for the study of gas blood exchange membrane. 展开更多
关键词 Extracorporeal membrane oxygenator Hollow fiber membrane Fabrication Surface modification Mass transfer
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BFS Parallel Algorithm Based on Sunway TaihuLight 认领 引用
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作者 Yang Zhou Jinhui He Hao Yang 《Journal of New Media》 2021年第2期63-72,共10页
In recent years,more and more attention has been paid to the research and application of graph structure.As the most typical representative of graph structure algorithm,breadth first search algorithm is widely used in... In recent years,more and more attention has been paid to the research and application of graph structure.As the most typical representative of graph structure algorithm,breadth first search algorithm is widely used in many fields.However,the performance of traditional serial breadth first search(BFS)algorithm is often very low in specific areas,especially in large-scale graph structure traversal.However,it is very common to deal with large-scale graph structure in scientific research.At the same time,the computing performance of supercomputer has also made great progress.China’s self-developed supercomputer system Sunway TaihuLight(SW)has won the top 500 list for three consecutive times.The huge computing performance of supercomputer is the key to solve this problem.It can be seen that if we use the computing power of supercomputing to solve the problem of large-scale graph structure traversal,the efficiency of graph structure traversal will be greatly improved.This paper expounds how to realize the breadth first search algorithm of graph structure on the Sunway TaihuLight,and achieved some results.In this way,MPI and thread library called athread of SW platform are used,and the traversal performance is improved dozens of times through the above related technologies and some partition methods of graph structure. 展开更多
关键词 Sunway TaihuLight breadth first search algorithm parallel computing
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Technical innovations of“Meng Xiang”ocean drilling vessel 认领 引用
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作者 Haibin ZHANG Zhenqiang XU +1 位作者 Chang ZHOU Jinhui HE 《Frontiers of Engineering Management》 CSCD 2025年第3期716-720,共5页
1 Overview of the“Meng Xiang”ocean drilling vessel.The“Meng Xiang”ocean drilling vessel represents China’s first independently developed,designed,and constructed scientific ocean drilling vessel(Fig.1).With a len... 1 Overview of the“Meng Xiang”ocean drilling vessel.The“Meng Xiang”ocean drilling vessel represents China’s first independently developed,designed,and constructed scientific ocean drilling vessel(Fig.1).With a length of 179.8 m,a width of 32.8 m,and a gross tonnage of 33,000GT,the vessel boasts impressive capabilities.It features a cruising range of 15,000 nautical miles,an endurance of 120 days,and can accommodate 180 personnel.The vessel is designed for global unrestricted navigation and operations,maintaining normal operational status in sea state 6 and ensuring survivability under super typhoon conditions up to category 16.It meets bridge clearance and port berthing requirements in major sea areas worldwide.Currently,the“Meng Xiang”leads globally in drilling capacity,scientific research functionality,intelligent automation levels,and operational cost efficiency among ocean drilling vessels. 展开更多
关键词 “Meng Xiang”ocean drilling vessel technical innovation modular design engineering management
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