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PL-HLANet:a semi-supervised approach for tunnel boring machine disc cutter wear prediction 认领 引用
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作者 Zhaoyang LI Wei TANG +3 位作者 Xinyuan WANG Huxiu XU Huayong YANG Jun ZOU 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第4期317-333,I0001-I0007,I0048,共17页
Unanticipated wear of tunnel boring machine(TBM)disc cutters is a critical factor causing project delays and cost overruns in tunneling engineering.Accurate,real-time prediction of the cutter’s wear state is therefor... Unanticipated wear of tunnel boring machine(TBM)disc cutters is a critical factor causing project delays and cost overruns in tunneling engineering.Accurate,real-time prediction of the cutter’s wear state is therefore essential for enabling predictive maintenance.Data-driven methods,particularly deep learning,have shown promise for this task,but their performance is constrained by the scarcity of high-quality labeled data in practical industrial settings.To address this challenge,we propose a novel,decoupled semi-supervised framework called PL-HLANet.The first component of this framework is a multi-view pseudolabeling(PL)module,which mines high-confidence supervisory signals from massive unlabeled data by leveraging heterogeneous views derived from feature engineering and diverse model architectures;it is followed by a consistency check to ensure label quality.This process effectively augments the training set while correcting for sampling bias.Subsequently,a specialized hierarchical hybrid attention network(HLANet)is used to make predictions.The HLANet organically integrates a temporal convolutional network(TCN)for local feature extraction,a bidirectional long short-term memory(Bi-LSTM)network for capturing temporal dynamics,and a custom attention mechanism for focusing on critical information.Experiments on a realworld tunneling dataset show that PL-HLANet significantly outperforms both supervised and mainstream semi-supervised baselines,such as the Mean Teacher and FixMatch.The framework’s effectiveness is further substantiated by validations of its architectural design and data-driven selection of hyperparameters.Moreover,PL-HLANet has a high inference speed,showcasing its practicality for real-world scenarios.Our work provides an effective solution for machining equipment monitoring in datascarce industrial environments. 展开更多
关键词 Tunnel boring machine(TBM) Cutter wear Semi-supervised learning Pseudo-labeling(PL) Temporal convolutional network Bidirectional long short-term memory(Bi-LSTM) Attention mechanism
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Integrated scalable hybrid spatial-spectral switch based on a bandpass ring-assisted asymmetric Mach–Zehnder interferometer 认领 引用
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作者 QISHEN LIANG ZICHAO ZHAO +8 位作者 HUIHUI ZHU HAORAN MA BIN ZHANG JIA GUO WEI LUO JUN ZOU YONG LIU YUEHAI WANG JIANYI YANG 《Photonics Research》 SCIE EI CAS CSCD 2026年第7期2808-2819,共12页
Photonic integrated switches with simultaneous space and wavelength selectivity represent a transformative technology for high-throughput data-center interconnection and scalable quantum networking.Silicon-based integ... Photonic integrated switches with simultaneous space and wavelength selectivity represent a transformative technology for high-throughput data-center interconnection and scalable quantum networking.Silicon-based integrated switches are particularly compelling due to their ultra-compact footprints and high-density integration capabilities.However,achieving scalable non-blocking operation remains challenging because of interconnectdriven footprint expansion that grows rapidly with system size.While conventional hybrid spatial-spectral switches(HSSs)can reduce individual unit dimensions,they require MN(2 log2N−1)∕2 switching elements for an N×N×Mλ configuration,creating a fundamental scalability bottleneck.To address this limitation,we propose and experimentally demonstrate a novel HSS architecture based on bandpass ring-assisted asymmetric Mach-Zehnder interferometers(RAMZIs)with a 3 dB bandwidth of 1.54 nm.Implemented on a silicon-oninsulator(SOI)platform,we realize a compact 4×4×2λ HSS using only six such elements(versus 12 in a conventional design),occupying a footprint of just 0.38 mm2 while supporting data transmission rates exceeding 8×30 Gb∕s.Crucially,the architecture can be further extended to N×N×Mλ configurations with an efficient scaling factor of N(Mlog2N−1)∕2.To our knowledge,this work delivers the most compact spatial-spectral switching system demonstrated to date,establishing a new benchmark for both scalability and efficiency in optical switching.These advances open pathways toward large-scale,high-performance switching solutions essential for next-generation data centers and quantum communication networks. 展开更多
关键词 bandpass ring assisted asymmetric Mach Zehnder interferometer photonic integrated switches space wavelength selectivity integrated switches integrated photonic switches scalability hybrid spatial spectral switching silicon insulator
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A single nucleotide substitution in BnaC02.LBD6 promoter causes blade shape variation in Brassica napus 认领 引用
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作者 Jinxiang Gao Bing Li +9 位作者 Pei Qin Sihao Zhang Xiaoting Li Yebitao Yang Wenhao Shen Shan Tang Jijun Li Liang Guo Jun Zou Jinxing Tu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第3期879-892,共14页
Leaf morphology constitutes a key component of the ideotype,and optimal leaf rolling contributes to compact plant architecture.Rapeseed(Brassica napus)is an important oilseed crop;however,the genetic mechanisms underl... Leaf morphology constitutes a key component of the ideotype,and optimal leaf rolling contributes to compact plant architecture.Rapeseed(Brassica napus)is an important oilseed crop;however,the genetic mechanisms underlying leaf shape development remain poorly understood,and corresponding germplasm resources for genetic improvement are limited.In this study,we identified a dominant mutant,INSIDE-ROLLING LEAF1(IRL1),which exhibits inward leaf rolling due to defective mesophyll cell development.The mutant also displays drooping siliques and a semi-dwarf phenotype,accompanied by a reduction of one to two effective branches.Through map-based cloning and functional complementation assays,we confirmed BnaC02G0201100ZS as the causal gene IRL1.This gene encodes LATERAL ORGAN BOUNDARIES DOMAIN6(BnaC02.LBD6).The phenotypic alterations in the IRL1 mutant result from elevated expression of BnaC02.LBD6,driven by a single nucleotide substitution within a DNA binding site in its promoter region.Overexpression of Bna C02.LBD6 recapitulated the IRL1 mutant phenotype,confirming its functional role.Haplotype analysis revealed a rare allelic variant in the BnaC02.LBD6 promoter associated with the unique leaf morphology of IRL1.Transcriptomic profiling indicated significant differential expression of genes involved in adaxial–abaxial leaf polarity establishment,secondary metabolic pathways,and hormone signaling networks.Our findings provide novel insights into the genetic regulation of leaf morphogenesis in rapeseed and offer valuable genetic resources for optimizing plant architecture in breeding programs. 展开更多
关键词 Brassica napus LATERAL ORGAN BOUNDARIES DOMAIN(LBD) BnaC02.LBD6 leaf shape map-based cloning plant architecture
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Autophagy in erectile dysfunction:focusing on apoptosis and fibrosis 认领 引用 被引量：2
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作者 Pei-Yue Luo Jun-Rong Zou +6 位作者 Tao Chen Jun Zou Wei Li Qi Chen Le Cheng Li-Ying Zheng Biao Qian 《Asian Journal of Andrology》 SCIE CAS CSCD 2025年第2期166-176,共11页
In most types of erectile dysfunction,particularly in advanced stages,typical pathological features observed are reduced parenchymal cells coupled with increased tissue fibrosis.However,the current treatment methods h... In most types of erectile dysfunction,particularly in advanced stages,typical pathological features observed are reduced parenchymal cells coupled with increased tissue fibrosis.However,the current treatment methods have shown limited success in reversing these pathologic changes.Recent research has revealed that changes in autophagy levels,along with alterations in apoptosis and fibrosis-related proteins,are linked to the progression of erectile dysfunction,suggesting a significant association.Autophagy,known to significantly affect cell fate and tissue fibrosis,is currently being explored as a potential treatment modality for erectile dysfunction.However,these present studies are still in their nascent stage,and there are limited experimental data available.This review analyzes erectile dysfunction from a pathological perspective.It provides an in-depth overview of how autophagy is involved in the apoptotic processes of smooth muscle and endothelial cells and its role in the fibrotic processes occurring in the cavernosum.This study aimed to develop a theoretical framework for the potential effectiveness of autophagy in preventing and treating erectile dysfunction,thus encouraging further investigation among researchers in this area. 展开更多
关键词 apoptosis autophagy erectile dysfunction fibrosis oxidative stress
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Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment 认领 引用 被引量：1
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作者 Shihua ZHANG Jianmin GUO +6 位作者 Yuting HE Zhi’ang SU Yao FENG Lan ZHANG Jun ZOU Xiquan WENG Yu YUAN 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2025年第2期107-123,共17页
Bone is a highly calcified and vascularized tissue.The vascular system plays a vital role in supporting bone growth and repair,such as the provision of nutrients,growth factors,and metabolic waste transfer.Moreover,th... Bone is a highly calcified and vascularized tissue.The vascular system plays a vital role in supporting bone growth and repair,such as the provision of nutrients,growth factors,and metabolic waste transfer.Moreover,the additional functions of the bone vasculature,such as the secretion of various factors and the regulation of bone-related signaling pathways,are essential for maintaining bone health.In the bone microenvironment,bone tissue cells play a critical role in regulating angiogenesis,including osteoblasts,bone marrow mesenchymal stem cells(BMSCs),and osteoclasts.Osteogenesis and bone angiogenesis are closely linked.The decrease in osteogenesis and bone angiogenesis caused by aging leads to osteoporosis.Long noncoding RNAs(lncRNAs)are involved in various physiological processes,including osteogenesis and angiogenesis.Recent studies have shown that lncRNAs could mediate the crosstalk between angiogenesis and osteogenesis.However,the mechanism by which lncRNAs regulate angiogenesis-osteogenesis crosstalk remains unclear.In this review,we describe in detail the ways in which lncRNAs regulate the crosstalk between osteogenesis and angiogenesis to promote bone health,aiming to provide new directions for the study of the mechanism by which lncRNAs regulate bone metabolism. 展开更多
关键词 Long noncoding RNA(lncRNA) Osteogenesis Bone angiogenesis Osteoporosis Bone microenvironment
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Phenotypic advantages and improved genomic stability following selection in advanced selfing-generations of Brassica allohexaploids 认领 引用
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作者 Yan Niu Rui Yang +9 位作者 Zelong Li Zhengxuan Huo Shihao Chang Entang Tian Han Qin Wallace A.Cowling Kadambot H.M.Siddique Annaliese S.Mason Sheng Chen Jun Zou 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第6期799-811,共13页
Allopolyploids often exhibit advantages in vigor and adaptability compared to diploids.A long-term goal in the economically important Brassica genus has been to develop a new allohexaploid crop type(AABBCC)by combinin... Allopolyploids often exhibit advantages in vigor and adaptability compared to diploids.A long-term goal in the economically important Brassica genus has been to develop a new allohexaploid crop type(AABBCC)by combining different diploid and allotetraploid crop species.However,early-generation allohexaploids often face challenges like unstable meiosis and low fertility,and the phenotypic performance of these synthetic lines has rarely been assessed.This study analyzes agronomic traits,fertility,and genome stability in ArArBcBcCcCc lines derived from four crosses between B.carinata and B.rapa after 9–11 selfing generations.Our results demonstrate polyploid advantage in vigor and seed traits,considerable phenotypic variation,and high fertility and genome stability.Meanwhile,parental genotypes significantly influence outcomes in advanced allohexaploids.Structural variants,largely resulting from A–C homoeologous exchanges,contribute to genomic variation and influence hexaploid genome stability,with the A sub-genome showing the highest variability.Both positive and negative impacts of SVs on fertility and seed weight are observed.Pseudo-euploids,frequently appearing,do not significantly affect fertility or other agronomic traits compared to euploids,indicating a potential pathway toward a stable allohexaploid species.These findings provide insights into the challenge and potential for developing an adaptable and stable Brassica hexaploid through selection. 展开更多
关键词 Brassica species Synthetic allohexaploid Homoeologous exchange Genome stability Polyploid advantage Structural variants
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Synthesis of Polydimethylsiloxane Ureas and Preparation of Magnetic Filaments for 3D Printing 认领 引用
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作者 Ekaterina A.Olenich Vadim V.Gorodov +9 位作者 Nina V.Demchenko Ulyana S.Andropova Kirill K.Bakanov Artur E.Krupnin Irina O.Kuchkina Sergei A.Kostrov Sergey A.Milenin Sergey N.Chvalun Jun Zou Elena Yu.Kramarenko 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第12期2325-2334,I0012,共10页
The aim of this study is to develop magnetopolymer composites suitable for fabricating soft magnetoactive robots via extrusion-based3D printing.Polysiloxane copolymers with urea fragments were synthesized and characte... The aim of this study is to develop magnetopolymer composites suitable for fabricating soft magnetoactive robots via extrusion-based3D printing.Polysiloxane copolymers with urea fragments were synthesized and characterized,and their thermophysical and rheological properties were investigated.This study provides an assessment of the potential for their further use in additive manufacturing.The obtained materials were utilized as matrices for creating magnetically active polymer composites by incorporating microparticles of carbonyl iron.Samples of complex geometries were printed using both neat and filled filaments,demonstrating the feasibility of employing these materials in extrusion-based 3D printing. 展开更多
关键词 Polydimethylsiloxane Polysiloxane ureas Magnetoactive materials 3D printing
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Advances in the study of mitophagy in osteoarthritis 认领 引用 被引量：18
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作者 Hong CAO Xuchang ZHOU +5 位作者 Bowen XU Han HU Jianming GUO Miao WANG Nan LI Jun ZOU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2024年第3期197-211,共15页
Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiatio... Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process.Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism.Therefore,maintaining mitochondrial homeostasis is an important strategy to mitigate OA.Mitophagy is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial homeostasis.Cumulative studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA.By reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA. 展开更多
关键词 Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis
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Fluid-driven artificialmuscles: bio-design, manufacturing, sensing, control, and applications 认领 引用 被引量：13
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作者 Chao Zhang Pingan Zhu +4 位作者 Yangqiao Lin Wei Tang Zhongdong Jiao Huayong Yang Jun Zou 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2021年第1期123-145,共23页
Developing artificial muscles that can replace biological muscles to accomplish various tasks iswhat we have long been aiming for.Recent advances in flexible materials and 3D printing technology greatly promote the de... Developing artificial muscles that can replace biological muscles to accomplish various tasks iswhat we have long been aiming for.Recent advances in flexible materials and 3D printing technology greatly promote the development of artificial muscle technology.A variety of flexible material-based artificial muscles that are driven by different external stimuli,including pressure,voltage,light,magnetism,temperature,etc.,have been developed.Among these,fluid-driven artificial muscles(FAMs),which can convert the power of fluid(gas or liquid)into the force output and displacement of flexible materials,are the most widely used actuation methods for industrial robots,medical instruments,and human-assisted devices due to their simplicity,excellent safety,large actuation force,high energy efficiency,and low cost.Herein,the bio-design,manufacturing,sensing,control,and applications of FAMs are introduced,including conventional pneumatic/hydraulic artificial muscles and several innovative artificial muscles driven by functional fluids.What’s more,the challenges and future directions of FAMs are discussed. 展开更多
关键词 Artificial muscles Fluid Bio-design Manufacturing Sensoring Control
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Endoscopic findings of gastrointestinal involvement in Chinese patients with Behcet's disease 认领 引用 被引量：14
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作者 Jun Zou Yan Shen +2 位作者 Da-Nian Ji Song-Bai Zheng Jian-Long Guan 《World Journal of Gastroenterology》 SCIE CAS 2014年第45期17171-17178,共8页
AIM:To report the incidence,clinical features and outcomes of gastrointestinal(GI)involvement in Behcet’s disease(BD).METHODS:A total of 168 consecutive patients with BD were screened and upper and lower GI endoscopi... AIM:To report the incidence,clinical features and outcomes of gastrointestinal(GI)involvement in Behcet’s disease(BD).METHODS:A total of 168 consecutive patients with BD were screened and upper and lower GI endoscopies were performed in 148 patients.Four hundred age-and sex-matched controls were enrolled for comparison.RESULTS:Fifty-two(35.1%)patients had GI lesions.After a mean follow-up of 10 mo,ileocecal ulcers had been confirmed in 20 patients,including active ulcer(s)in 18 patients,but no ileocecal ulceration was found in controls.GI symptoms were present in 14 patients with active ulcer(s),while 4 patients with smaller ulcer were asymptomatic.Endoscopic features of ileocecalulcer were:a single ulcer(50%),larger than 1 cm in diameter(72.2%),and round/oval or volcano-type in shape(83.3%).Compared with patients without GI involvement,less ocular lesions,lower levels of albumin,erythrocyte count and hemoglobin,and higher levels of C-reactive protein and erythrocyte sedimentation rate were confirmed in the intestinal BD group.Four patients had esophageal ulcers in the BD group but no case in controls.The other endoscopic findings were similar between the two groups.The prevalence of Helicobacter pylori infection was similar in both groups.Most patients received an immunomodulator and responded well.CONCLUSION:GI lesions commonly occur in Chinese BD patients.The most frequently involved area is the ileocecal region.Esophageal ulcer might be a rare but unique lesion. 展开更多
关键词 Behcet's disease Gastrointestinal involve-ment Ulcer Endoscopy Case-controlled
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Observation-based Estimation of Aerosol-induced Reduction of Planetary Boundary Layer Height 认领 引用 被引量：10
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作者 Jun ZOU Jianning SUN +3 位作者 Aijun DING Minghuai WANG Weidong GUO Congbin FU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2017年第9期1057-1068,共12页
Radiative aerosols are known to influence the surface energy budget and hence the evolution of the planetary boundary layer. In this study, we develop a method to estimate the aerosol-induced reduction in the planetar... Radiative aerosols are known to influence the surface energy budget and hence the evolution of the planetary boundary layer. In this study, we develop a method to estimate the aerosol-induced reduction in the planetary boundary layer height （PBLH） based on two years of ground-based measurements at a site, the Station for Observing Regional Processes of the Earth System （SORPES）, at Nanjing University, China, and radiosonde data from the meteorological station of Nanjing. The observations show that increased aerosol loads lead to a mean decrease of 67.1 W m-2 for downward shortwave radiation （DSR） and a mean increase of 19.2 W m-2 for downward longwave radiation （DLR）, as well as a mean decrease of 9.6 W m-2 for the surface sensible heat flux （SHF） in the daytime. The relative variations of DSR, DLR and SHF are shown as a function of the increment of column mass concentration of particulate matter （PM2.5）. High aerosol loading can significantly increase the atmospheric stability in the planetary boundary layer during both daytime and nighttime. Based on the statistical relationship between SHF and PM2.5 column mass concentrations, the SHF under clean atmospheric conditions （same as the background days） is derived. In this case, the derived SHF, together with observed SHF, are then used to estimate changes in the PBLH related to aerosols. Our results suggest that the PBLH decreases more rapidly with increasing aerosol loading at high aerosol loading. When the daytime mean column mass concentration of PM2.5 reaches 200 mg m-2, the decrease in the PBLH at 1600 LST （local standard time） is about 450 m. 展开更多
关键词 aerosol radiation atmospheric stability surface sensible heat flux planetary boundary layer height
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Co-regulation of circadian clock genes and microRNAs in bone metabolism 认领 引用 被引量：9
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作者 Tingting LI Shihua ZHANG +3 位作者 Yuxuan YANG Lingli ZHANG Yu YUAN Jun ZOU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2022年第7期529-546,共18页
Mammalian bone is constantly metabolized from the embryonic stage,and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation,mediated by osteoclasts and osteoblasts.It... Mammalian bone is constantly metabolized from the embryonic stage,and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation,mediated by osteoclasts and osteoblasts.It is widely recognized that circadian clock genes can regulate bone metabolism.In recent years,the regulation of bone metabolism by non-coding RNAs has become a hotspot of research.MicroRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism,including circadian clock genes.However,research in this field has been conducted only in recent years and the mechanisms involved are not yet well established.Recent studies have focused on how to target circadian clock genes to treat some diseases,such as autoimmune diseases,but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases.Therefore,in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs,aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis. 展开更多
关键词 Circadian rhythm Circadian clock gene MicroRNAs Bone metabolism
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Protective effects of human umbilical cord mesenchymal stem cell vein transplantation against spinal cord ischemia/reperfusion injury in rats 认领 引用 被引量：7
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作者 Jun Zou Minfeng Gan +2 位作者 Xuesong Zhu Dechun Geng Huilin Yang 《Neural Regeneration Research》 SCIE CAS 2010年第3期171-177,共7页
BACKGROUND:The majority of studies addressing spinal cord ischemiaeperfusion injury(SCIRI)have focused on drugs,proteins,cytokines,and various surgical techniques.A recent study reports that human umbilical cord mesen... BACKGROUND:The majority of studies addressing spinal cord ischemiaeperfusion injury(SCIRI)have focused on drugs,proteins,cytokines,and various surgical techniques.A recent study reports that human umbilical cord mesenchymal stem cell(hUCMSC)transplantation achieves good therapeutic effects,but the mechanisms underlying nerve protection remain poorly understood.OBJECTIVE:To observe survival of transplanted hUCMSCs in SCIRI rat models and the influence on motor function in the hind limbs,to determine interleukin-8 expression and cellular apoptosis in spinal cord tissues,and to verify the hypothesis that hUCMSC transplantation exhibits protective effects on SCIRI.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of the Department of Orthopedics in the First Affiliated Hospital of Soochow University,China between January 2007 and December 2008.MATERIALS:hUCMSCs were harvested from umbilical cord blood of healthy pregnant women after parturition in the Obstetrical Department of the First Affiliated Hospital of Soochow University,China.Rabbit anti-human BrdU monoclonal antibody was provided by DAKO,USA.Terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)Kit and enzyme-linked immunosorbent assay(ELISA)Kit were purchased by Wuhan Boster,China.METHODS:A total of 72 healthy,Wistar,adult rats were randomly assigned to three groups:sham-surgery,model,and transplantation,with 24 rats in each group.SCIRI was induced in the model and transplantation groups via the abdominal aorta block method.The infrarenal abdominal aorta was not blocked in the sham-surgery group.Prior to abdominal aorta occlusion,0.203 mL bromodeoxyuridine(BrdU)-Iabeled hUCMSCs suspension(cell concentration 5×103/uL)was injected through the great saphenous vein of the hind limb,and an equal volume of physiological saline was administered to the model and sham-surgery groups.MAIN OUTCOME MEASURES:Pathological observation of rat spinal cord tissues was performed by hematoxylin-eosin staining at 6,24,and 48 hours post-surgery.Immunohistochemistry was applied to determine hUCMSCs survival in the spinal cord.The amount of cellular apoptosis and interleukin-8 expression in spinal cord tissues was assayed utilizing the TUNEL and ELISA methods,respectively.Motor function in the hind limbs was evaluated according to Jacob's score.RESULTS:Numerous BrdU-positive cells were observed in spinal cord tissues from the transplantation group.The number of apoptotic cells and interleukin-8 levels significantly decreased in the transplantation group(P〈0.05),pathological injury was significantly ameliorated,and motor function scores significantly increased(P〈0.05)compared with the model group.CONCLUSION:Via vein transplantation,hUCMSCs were shown to reach and survive in the injury area.Results suggested that the transplanted hUCMSCs contributed to significantly improved pathological changes in the injured spinal cord,as well as motor function,following SCIRI.The protective mechanism correlated with inhibition of cellular apoptosis and reduced production of inflammatory mediators. 展开更多
关键词 human umbilical cord mesenchymal stem cells spinal cord ischemiaeperfusion injury protective effect apoptosis inflammatory mediators neural regeneration
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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients 认领 引用 被引量：8
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作者 Guixin Li Danli Yang +8 位作者 Xin Liu Ting Zhang Hui Liu Jun Zou Zimeng Xu Xiangmei Chen Lizhong Dai Hongsong Chen Fengmin Lu 《Virologica Sinica》 SCIE CAS CSCD 2024年第2期319-330,共12页
Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative status.However,the replicative capacity ... Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative status.However,the replicative capacity of HBV with PC/BCP mutations remains ambiguous.Herein,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the mutation.Both PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse models.In human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic core protein accumulation.Mechanistically,preC RNA harboring PC mutation could serve as mRNA to express core and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative status.Additionally,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric mice.This study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression. 展开更多
关键词 Hepatitis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress
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Optimal design of Stewart platforms based on expanding the control bandwidth while considering the hydraulic system design 认领 引用 被引量：5
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作者 Wei WANG Hua-yong YANG +2 位作者 Jun ZOU Xiao-dong RUAN Xin FU 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS 2009年第1期22-30,共9页
We proposed an optimal design method to expand the bandwidth for the control of large hydraulic Stewart platform.The method is based on generalized natural frequency and takes hydraulic oil into consideration.A Lagran... We proposed an optimal design method to expand the bandwidth for the control of large hydraulic Stewart platform.The method is based on generalized natural frequency and takes hydraulic oil into consideration.A Lagrangian formulation which considers the whole leg inertia is presented to obtain the accurate equivalent mass matrix.Using the model,the effect of leg inertia and the influence of design parameters on the generalized natural frequency are investigated.Finally,numerical examples are presented to validate and confirm the efficiency of the mathematical model.The results show that the leg inertia,especially the piston part plays an important role in the dynamics.The optimum diameter ratio of the base to the moving platform is between 2 and 3,and the optimum joint angle ratio of the base to the moving platform is about 1.The smaller joint angles and a longer leg stroke are favorable for raising system frequencies.The system oil should be preprocessed for large platforms with a requirement for good dynamic performance. 展开更多
关键词 Large Gough-Stewart platform Optimal design Control bandwidth Leg inertia Generalized natural frequency
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Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells 认领 引用 被引量：5
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作者 Hong CAO Xuchang ZHOU +6 位作者 Bowen XU Han HU Jianming GUO Yuwei MA Miao WANG Nan LI Jun ZOU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2024年第3期212-232,共21页
The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu... The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD. 展开更多
关键词 Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation
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Sustainable and untethered soft robots created using printable and recyclable ferromagnetic fibers 认领 引用 被引量：4
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作者 Wei Tang Yidan Gao +4 位作者 Zeyu Dong Dong Han Vadim V.Gorodov Elena Y.Kramarenko Jun Zou 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第6期926-937,共12页
Integrated printing of magnetic soft robots with complex structures using recyclable materials to achieve sustainability of the soft robots remains a persistent challenge.Here,we propose a kind of ferromagnetic fibers... Integrated printing of magnetic soft robots with complex structures using recyclable materials to achieve sustainability of the soft robots remains a persistent challenge.Here,we propose a kind of ferromagnetic fibers that can be used to print soft robots with complex structures.These ferromagnetic fibers are recyclable and can make soft robots sustainable.The ferromagnetic fibers based on thermoplastic polyurethane(TPU)/NdFeB hybrid particles are extruded by an extruder.We use a desktop three-dimensional(3D)printer to demonstrate the feasibility of printing two-dimensional(2D)and complex 3D soft robots.These printed soft robots can be recycled and reprinted into new robots once their tasks are completed.Moreover,these robots show almost no difference in actuation capability compared to prior versions and have new functions.Successful applications include lifting,grasping,and moving objects,and these functions can be operated untethered wirelessly.In addition,the locomotion of the magnetic soft robot in a human stomach model shows the prospect of medical applications.Overall,these fully recyclable ferromagnetic fibers pave the way for printing and reprinting sustainable soft robots while also effectively reducing e-waste and robotics waste materials,which is important for resource conservation and environmental protection. 展开更多
关键词 Ferromagnetic fibers Sustainable soft robots Three-dimensional printing Recyclable soft materials Medical applications
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Genome-wide prediction for hybrids between parents with distinguished difference on exotic introgressions in Brassica napus 认领 引用 被引量：5
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作者 Dandan Hu Yusheng Zhao +7 位作者 Jinxiong Shen Xiangxiang He Yikai Zhang Yong Jiang Rod Snowdon Jinling Meng Jochen C.Reif Jun Zou 《The Crop Journal》 SCIE CSCD 2021年第5期1169-1178,共10页
Extensive exotic introgression could significantly enlarge the genetic distance of hybrid parental populations to promote strong heterosis.The goal of this study was to investigate whether genome-wide prediction can s... Extensive exotic introgression could significantly enlarge the genetic distance of hybrid parental populations to promote strong heterosis.The goal of this study was to investigate whether genome-wide prediction can support pre-breeding in populations with exotic introgressions.We evaluated seed yield,seed yield related traits and seed quality traits of 363 hybrids of Brassica napus (AACC) derived from two parental populations divergent on massive exotic introgression of related species in three environments.The hybrids presented strong heterosis on seed yield,which was much higher than other investigated traits.Five genomic best linear unbiased prediction models considering the exotic introgression and different marker effects (additive,dominance,and epistatic effects) were constructed to test the prediction ability for different traits of the hybrids.The analysis showed that the trait complexity,exotic introgression,genetic relationship between the training set and testing set,training set size,and environments affected the prediction ability.The models with best prediction ability for different traits varied.However,relatively high prediction ability (e.g.,0.728 for seed yield) was also observed when the simplest models were used,excluding the effects of the special exotic introgression and epistasis effect by5-fold cross validation,which would simplify the prediction for the trait with complex architecture for hybrids with exotic introgression.The results provide novel insights and strategies for genome-wide prediction of hybrids between genetically distinct parent groups with exotic introgressions. 展开更多
关键词 Hybrid Genome-wide prediction Exotic introgression Brassica napus Heterosis
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A comparative study of the land-atmosphere energy and water exchanges over the Tibetan Plateau and the Yangtze River Region 认领 引用 被引量：4
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作者 Nan Yao Yaoming Ma +3 位作者 Binbin Wang Jun Zou Jianning Sun Zhipeng Xie 《Atmospheric and Oceanic Science Letters》 CSCD 2024年第2期52-59,共8页
A comprehensive understanding of energy and water cycle characteristics in different regions is crucial for studying local land-atmosphere interactions and predicting regional weather and climate change.To explore sim... A comprehensive understanding of energy and water cycle characteristics in different regions is crucial for studying local land-atmosphere interactions and predicting regional weather and climate change.To explore similarities and differences in land-atmosphere energy and water exchanges between two regions-the Tibetan Plateau(TP),characterized by higher elevation and a drier climate,and the Yangtze River Region(YRR),with lower elevation and a wetter climate-this study analyzed and compared the radiation components and the turbulent heat fluxes at eight sites covering various land-cover types,including alpine desert and alpine grassland on the TP,as well as urban and grassland on the YRR.The following results were obtained:(1)Over the TP,the annual mean incoming and outgoing shortwave radiation are 251.3 and 59.6 W m-2,which are 1.70 and 2.87 times the values in the YRR,respectively.The incoming and outgoing longwave radiation are 231.5 and 338.0 W m-2,which are 0.64 and 0.83 times those in the YRR,respectively.However,the difference in net radiation is relatively small.(2)In grassland over both the TP and YRR,the latent heat fluxes have higher values of 35.0 and 38.8 W m-2,respectively,leading to a higher heating efficiency.Alpine desert has the highest sensible heat flux(SH)value of 42.1 W m-2,due to sparse vegetation and lower soil moisture,followed closely by urban land cover with an average SH value of 38.2 W m-2.These results highlight the different characteristics of land-atmosphere interaction across different land covers in different climatic contexts,laying the groundwork for future investigations of additional land-atmosphere coupling processes. 展开更多
关键词 Energy and water exchanges Radiation components Surface heat flux Tibetan Plateau YangtzeRiver Region Land-cover types
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选区激光熔化成形件磨损特性综述(英文) 认领 引用 被引量：9
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作者 Yi ZHU Jun ZOU Hua-yong YANG 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2018年第2期95-110,共16页
通过对文献的综述,本文总结了已有的选区激光熔化成形件的磨损特性研究,并提出了未来的研究方向,为该技术成形摩擦副的推广提供参考。本文通过干磨、边界润滑下的磨损、腐蚀以及冲蚀四个方面介绍了已有研究。总体来看,选区激光熔化成形... 通过对文献的综述,本文总结了已有的选区激光熔化成形件的磨损特性研究,并提出了未来的研究方向,为该技术成形摩擦副的推广提供参考。本文通过干磨、边界润滑下的磨损、腐蚀以及冲蚀四个方面介绍了已有研究。总体来看,选区激光熔化成形件得益于均匀细晶,高致密度成形件的磨损率普遍低于传统制造件,然而孔隙的出现将降低成形件的抗磨性能。未来的研究内容主要包括孔隙对润滑的影响规律及其机理,以及如何通过主动控制激光工艺参数提高选区激光熔化成形件的抗磨能力。 展开更多
关键词 选区激光熔化 磨损 增材制造 润滑 孔隙
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