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Microbial reprogramming of immunogenic cell death:a new paradigm in tumor immunotherapy 认领 引用
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作者 Yilin Li Huiyue Zhang +5 位作者 Yun Feng Kun Fang Yue Wang Yuhang Zhou Tao Sun Junnan Xu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第5期657-677,共21页
Immunogenic cell death(ICD),a special form of cell death,transforms“cold”tumors into“hot”tumors by fulfilling the following three key conditions:antigenicity;adjuvanticity;and a suitable tumor microenvironment(TME... Immunogenic cell death(ICD),a special form of cell death,transforms“cold”tumors into“hot”tumors by fulfilling the following three key conditions:antigenicity;adjuvanticity;and a suitable tumor microenvironment(TME).Tumor cells release damageassociated molecular patterns(DAMPs)during ICD,thereby activating the dendritic–cytotoxic T cell axis to elicit systemic antitumor immune responses.However,drug resistance and immune-related adverse effects often limit traditional ICD inducers,including chemotherapy and radiotherapy.Notably,microbiota and microbial metabolites can trigger ICD in tumor cells,leading to the release of DAMPs,modulation of immune cell functions,and TME remodeling.This study comprehensively reviews the mechanisms underlying ICD regulation via microbiota and microbial metabolites.In addition,this review examines emerging strategies,including engineered microbiota,microbial-based combination therapies(such as incorporating immune checkpoint inhibitors or chemotherapy),and dietary interventions.Despite challenges associated with individual microbiota variability and mechanistic complexity,this study highlights the potential of microbiota-mediated ICD modulation as a novel paradigm for personalized cancer therapy,thereby providing insights for future directions of scientific research. 展开更多
关键词 Immunogenic cell death damage-associated molecular patterns microbiota and microbial metabolites tumor microenvironment antitumor immune responses
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抗体偶联药物治疗HER2阳性晚期乳腺癌的研究新进展 认领 引用
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作者 马艺文 李晓睿 +2 位作者 王家行 徐君南 孙涛 《中国肿瘤临床》 CAS CSCD 北大核心 2026年第9期441-446,共6页
抗体偶联药物(antibody-drug conjugates,ADC)的出现,为HER2阳性晚期乳腺癌的治疗带来突破性进展,并持续推动治疗模式变革。以德曲妥珠单抗(trastuzumab deruxtecan,T-DXd)为代表的新一代ADC显著改善了患者预后,推动治疗策略由后线向更... 抗体偶联药物(antibody-drug conjugates,ADC)的出现,为HER2阳性晚期乳腺癌的治疗带来突破性进展,并持续推动治疗模式变革。以德曲妥珠单抗(trastuzumab deruxtecan,T-DXd)为代表的新一代ADC显著改善了患者预后,推动治疗策略由后线向更早治疗阶段拓展。同时,维迪西妥单抗(disitamab vedotin,RC48)、A166和SHR-A1811等国产创新ADC快速发展,为临床提供了更多治疗选择。HER2表达异质性、治疗序贯优化及药物可及性等问题逐渐成为影响临床获益进一步提升的重要挑战。未来ADC治疗的发展将聚焦于精准患者筛选、联合治疗策略优化、治疗阶段前移以及新一代ADC平台研发。本文对HER2阳性晚期乳腺癌ADC治疗的当前格局、关键挑战及未来发展方向进行归纳与总结,以期为临床实践提供参考。 展开更多
关键词 抗体偶联药物 HER2阳性 晚期乳腺癌 精准医学
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From residual risk to precision intervention:the evolving role of minimal residual disease in breast cancer management 认领 引用 被引量：1
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作者 Junnan Xu Kun Fang +3 位作者 Xiaoxi Li Li Han Shulan Sun Tao Sun 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第12期1493-1514,共22页
Breast cancer mortality is driven predominantly by metastasis,which affects 20-30%of patients with early-stage disease despite guideline-directed therapies.Because conventional imaging modalities currently lack sensit... Breast cancer mortality is driven predominantly by metastasis,which affects 20-30%of patients with early-stage disease despite guideline-directed therapies.Because conventional imaging modalities currently lack sensitivity to identify residual disease,molecular-level monitoring must be developed.Circulating tumor DNA(ctDNA)profiling currently enables transformative minimal residual disease(MRD)detection and can quantify tumor burden at low variant allele frequencies.This review provides a comprehensive overview of MRD in breast cancer,including its definition,detection technologies,positivity thresholds,pathophysiology,clinical applications in adjuvant and neoadjuvant settings,ongoing clinical trials,challenges,and future directions.ctDNA-defined MRD has potential as a precision tool for adaptive therapy,and might facilitate post-adjuvant interception,whereby targeted therapies are administered to eradicate micro-metastases before radiographic recurrence.Persistent challenges include MRD assay standardization,subtype-specific MRD thresholds,tumor heterogeneity,and positioning MRD as a potentially valuable tool for precision management in breast cancer. 展开更多
关键词 Circulating tumor DNA minimal residual disease breast cancer tumor-informed MRD precision management
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Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment 认领 引用 被引量：2
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作者 Yue Wang Yiwen Wang +3 位作者 Yuhang Zhou Yun Feng Tao Sun Junnan Xu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第11期977-994,共18页
Most studies on the human gut microbiome have focused on the bacterial fraction rather than fungal biomics,which as resulted in an incomplete understanding of the fungal microbiome.Recent advances in microbiota detect... Most studies on the human gut microbiome have focused on the bacterial fraction rather than fungal biomics,which as resulted in an incomplete understanding of the fungal microbiome.Recent advances in microbiota detection and next-generation sequencing technology have boosted an increase in research on fungi.Symbiotic fungi have become increasingly influential in health and disease and modulate various physiologic functions within the host.Fungal infections can result in high morbidity and mortality rates and are life-threatening in some immunocompromised patients.In addition to bacterial dysbiosis,alterations in fungal communities are important and have been linked to many diseases,including asthma,mental illness,and various cancers.When investigating cancer it is imperative to consider the role of fungi alongside viruses and bacteria.This review examined the impact of intestinal fungi and peri-tumor fungi on tumorigenesis,cancer progression,and response to anticancer therapies.The review highlights the specific involvement of some fungal species in cancers include digestive tract tumors such as colorectal,pancreatic,liver,and gastric cancers,as well as non-digestive tract tumors such as lung,melanoma,breast,and ovarian cancers.Furthermore,fungal mechanisms of action,including fungus-host recognition and immune regulation,biofilm formation,toxin and metabolite production in the tumor microenvironment,and the complex effects of fungus-bacteria interactions on tumorigenesis and development,highlight the significance of potential biomarkers in cancer diagnosis and treatment. 展开更多
关键词 Gut microbiota fungi intratumoral cancer cancer treatment responsiveness Candida albicans
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AICellCounter:A Machine Learning-Based Automated Cell Counting Tool Requiring Only One Image for Training 认领 引用
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作者 Junnan Xu Andong Wang +7 位作者 Yunfeng Wang Jingting Li Ruxia Xu Hao Shi Xiaowen Li Yu Liang Jianming Yang Tian-Ming Gao 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第1期83-88,共6页
Dear Editor,To decipher brain functions,brain cells are generally prelabeled and then imaged using a high-resolution confocal system,and manual or automatic counting methods are widely used in the quantitative and sem... Dear Editor,To decipher brain functions,brain cells are generally prelabeled and then imaged using a high-resolution confocal system,and manual or automatic counting methods are widely used in the quantitative and semiquantitative analysis of these confocal images.Therefore,cell counting becomes a bottleneck in efficient analysis because manual counting is laborious and time-consuming.Therefore,an accurate and user-friendly automated cell counting tool is needed for biological researchers. 展开更多
关键词 consuming analysis manual
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基于超高效串联质谱的氨基酸代谢组学预测晚期乳腺癌化疗反应初探 认领 引用 被引量：5
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作者 徐君南 李晓睿 孙涛 《中国肿瘤临床》 CAS CSCD 北大核心 2017年第24期1253-1257,共5页
目的:探讨晚期乳腺癌患者化疗前(基线)和化疗第1个疗程后(预后)血清中32种氨基酸的变化,预测其指导晚期乳腺癌化疗敏感性的价值。方法:选取2015年3月至2016年10月于辽宁省肿瘤医院行化疗的女性晚期乳腺癌患者73例,分别在化疗前和化疗第... 目的:探讨晚期乳腺癌患者化疗前(基线)和化疗第1个疗程后(预后)血清中32种氨基酸的变化,预测其指导晚期乳腺癌化疗敏感性的价值。方法:选取2015年3月至2016年10月于辽宁省肿瘤医院行化疗的女性晚期乳腺癌患者73例,分别在化疗前和化疗第1个疗程后采集外周血2 m L,经超高效串联质谱(LC-MS/MS)检测血清中32种氨基酸的含量水平。采用影像学检查对化疗2~4个疗程后患者行预后评估,分为好转组和恶化组,并分析氨基酸含量水平的变化。结果:32种氨基酸含量水平为3~180000 pmol/L。与基线相比,好转组的甘氨酸和L-谷氨酰胺相对含量显著上升,而恶化组显著下降;好转组的肌氨酸显著下降,而恶化组变化不明显;好转组和恶化组的L-苏氨酸、牛磺酸、亚氨基二乙酸和L-谷氨酸均显著上升。结论:甘氨酸和肌氨酸等氨基酸在行化疗前和化疗第1个疗程后的变化对晚期乳腺癌化疗疗效具有一定的预测价值,较影像学检查可能更早预测化疗疗效,有助于指导患者的治疗。 展开更多
关键词 晚期乳腺癌 氨基酸代谢 化疗敏感性 超高效串联质谱
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Feasibility of telesurgery using fifth-generation wireless cellular technology and dedicated internet lines for cross-continental procedures:A pilot study 认领 引用
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作者 Qingbo Huang Ye Wang +16 位作者 Zhi Li Alberto Breda Richard Pierre Gaston Vito Pansadoro Giuseppe Simone Yibo Chen Songliang Du Yu Gao Qilong Jiao Baojun Wang Junnan Xu Gen Cheng Xiangping Zhang Lingling Wang Hongzhao Li Xin Ma Xu Zhang 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第10期1575-1577,共3页
To the Editor:Telesurgery represents a promising advancement in medical technology,allowing skilled surgeons to perform complex procedures remotely.By leveraging high-speed internet infrastructure such as 5th generati... To the Editor:Telesurgery represents a promising advancement in medical technology,allowing skilled surgeons to perform complex procedures remotely.By leveraging high-speed internet infrastructure such as 5th generation mobile communication technology(5G),telesurgery has the potential to overcome geographical constraints and expand access to expert surgical care.However,its successful implementation depends on several critical factors,including stable,low-latency data transmission,reliable network performance,and the ability to maintain surgical precision over long distances.Patel et al[1]established a remote surgical connection between Orlando and Shanghai using 5G,Wi-Fi,and fiber-optic technologies,and performed 10 robot-assisted nephrectomies on pig models.Rogers et al[2]reported on a short-distance study in which three surgeons completed remote robot-assisted prostatectomies,demonstrating that telesurgery can be safely performed using low-latency telecommunications.Additionally,our team has previously conducted a series of remote animal model procedures and short-distance clinical trials.[3,4]In this study,we evaluated the feasibility of cross-continental telesurgery,specifically examining the use of 5G networks and dedicated internet lines to ensure high-speed,uninterrupted communication between the surgical console and operative site[Figure 1A]. 展开更多
关键词 telesurgery G overcome geographical constraints surgical precision wireless cellular technology cross continental procedures th generation mobile communication technology g telesurgery remote surgical connection
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus:NEOTAX,a phase 2 study 认领 引用 被引量：14
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作者 Liangyou Gu Cheng Peng +15 位作者 Qiyang Liang Qingbo Huang Deqiang Lv Houming Zhao Qi Zhang Yu Zhang Peng Zhang Shichao Li Junnan Xu Luyao Chen Yongpeng Xie Jinhang Li Gang Guo Xu Zhang Baojun Wang Xin Ma 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2024年第11期5157-5165,共9页
The potential benefit of neoadjuvant toripalimab plus axitinib in cases with clear cell renal cell carcinoma(ccRCC)and inferior vena cava tumor thrombus(IVC-TT)remains unclear.NEOTAX was a phase 2 study to investigate... The potential benefit of neoadjuvant toripalimab plus axitinib in cases with clear cell renal cell carcinoma(ccRCC)and inferior vena cava tumor thrombus(IVC-TT)remains unclear.NEOTAX was a phase 2 study to investigate the efficacy and safety of neoadjuvant toripalimab plus axitinib in patients with ccRCC and IVC-TT(ChiCTR2000030405).The primary endpoint was the down-staging rate of IVC-TT level.Secondary endpoints included change in TT length,response rate,percentage change in surgical approach,surgical morbidity,progression-free survival(PFS),safety,and biomarker analyses.In all,25 patients received study treatment,44.0%(11/25)patients had a reduction in thrombus level,and none experienced an increase in Mayo level.The median change in tumor thrombus length was−2.3 cm(range:−7.1 to 1.1 cm).Overall,61.9%(13/21)patients experienced changes in surgical strategy compared with planned surgery,three patients experienced major complications.The median PFS was 25.3 months(95%CI:17.0-NE).The 1-year PFS was 89.1%(95%CI:62.7-97.2).No any of grade 4 or 5 treatment-related adverse event was identified.Biopsy samples of nonresponders exhibited increased T cytotoxic cell infiltration,but these cells were predominantly PD-1 positive.Biopsy samples of responders exhibited lower T helper cells,however,their subtype,regulatory T cells remained unchanged.In surgical samples of the TT,non-responders exhibited increased CD8T_01_GZMK_CXCR4 subset T cells.NEOTAX met preset endpoints proving that toripalimab in combination with axitinib downstages IVC-TT in a significant proportion of patients leading to simplification in the procedure of surgery. 展开更多
关键词 thrombus unchanged phase
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An Axiom System of Probabilistic Mu-Calculus 认领 引用
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作者 Wanwei Liu Junnan Xu +2 位作者 David N.Jansen Andrea Turrini Lijun Zhang 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2022年第2期372-385,共14页
Mu-calculus(a.k.a.μTL)is built up from modal/dynamic logic via adding the least fixpoint operatorμ.This type of logic has attracted increasing attention since Kozen’s seminal work.PμTL is a succinct probabilistic ... Mu-calculus(a.k.a.μTL)is built up from modal/dynamic logic via adding the least fixpoint operatorμ.This type of logic has attracted increasing attention since Kozen’s seminal work.PμTL is a succinct probabilistic extension of the standardμTL obtained by making the modal operators probabilistic.Properties of this logic,such as expressiveness and satisfiability decision,have been studied elsewhere.We consider another important problem:the axiomatization of that logic.By extending the approaches of Kozen and Walukiewicz,we present an axiom system for PμTL.In addition,we show that the axiom system is complete for aconjunctive formulas. 展开更多
关键词 PμTL axiom system aconjunctive formula tableau approach
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