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Vascular and musculoskeletal interactions:structure,function,and therapeutic strategies for sarcopenia and osteoporosis 认领 引用
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作者 Liming Zheng Ke Zhao +5 位作者 Xu Wang Tianxiao Feng Ning Liu Linghui Li Liguo Zhu Xu Wei 《MedScience》 SCIE CAS CSCD 2026年第2期247-267,共21页
Muscle and bone,key tissues that maintain the body’s structure and function,are closely connected via mechanical and biochemical interactions.The vascular system plays a crucial role in musculoskeletal health,not onl... Muscle and bone,key tissues that maintain the body’s structure and function,are closely connected via mechanical and biochemical interactions.The vascular system plays a crucial role in musculoskeletal health,not only by providing nutrients and oxygen but also by regulating growth,regeneration,and metabolism.This review systematically examines the vascular structure and function of the musculoskeletal system,and explores the complex biochemical signaling networks involving myokines,osteokines,and vascular‑derived factors.Vascular dysfunction is a key contributor to the pathogenesis of degenerative diseases like sarcopenia(SP)and osteoporosis(OP),making vascular‑targeted therapies a promising approach for their treatment.Potential strategies for restoring vascular health include molecular targeting,exercise training,nutritional supplementation,cardiovascular pharmacotherapy,hormone therapies,and tissue engineering—all of which may help slow aging‑related musculoskeletal degeneration.Despite significant research progress,challenges remain in the clinical translation of these interventions.Future research should focus on elucidating the molecular mechanisms of muscle‑bone‑vascular interactions and exploring innovative tissue engineering techniques.This review provides a comprehensive understanding of the dynamic interactions between muscle,bone,and vascular systems,highlighting the importance of vascular health in musculoskeletal disease management,and proposes novel vascular‑targeted approaches for the prevention and treatment of musculoskeletal disorders. 展开更多
关键词 vascular system musculoskeletal system sarcopenia osteoporosis therapeutic strategies
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Distribution and Transmission of Apramycin-Resistant Escherichia coli from Humans and Animal-Producing Sectors:A Multicenter,Cross-Sectional,and One Health Study 认领 引用
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作者 Yue Cao Dejun Liu +23 位作者 Fen Pan Zhenzhen Liu Qin Zhang Chengtao Sun Li Ding Siquan Shen Weishuai Zhai Rina Bai Zhiyu Zou Yiqing Wang Lu Yang Zexun Lv Bo Fu Shizhen Ma Yao Wang Ke Zhao Tingxuan Shi Yingbo Shen Rong Zhang Timothy R.Walsh Jianzhong Shen Fupin Hu Yang Wang Congming Wu 《Engineering》 SCIE EI CSCD 2026年第5期116-126,共11页
Apramycin,an aminoglycoside antibiotic used exclusively in veterinary medicine,has attracted growing interest for its potential clinical application owing to its low toxicity and potent activity against multidrug-resi... Apramycin,an aminoglycoside antibiotic used exclusively in veterinary medicine,has attracted growing interest for its potential clinical application owing to its low toxicity and potent activity against multidrug-resistant(MDR)bacteria.Despite the completion of two Phase I clinical trials,apramycin resistance dynamics across One Health interfaces remain poorly understood.This study,conducted from 2020to 2023 in Chengdu,Qingdao,and Shanghai,China,collected 5160 non-duplicate samples from hospitals,broiler and pig farms and slaughterhouses,and markets.We identified 1394 isolates of apramycinresistant Escherichia coli(E.coli)(AREC),with the highest detection rates in animal feces(58%,700/1214),followed by animal carcasses(47%,183/393),fresh meat(35%,229/659),environments(21%,127/593),human feces(7%,103/1425),and clinical samples(5%,42/876).Detection rates were higher in broiler-producing chains(57%,742/1292)than in pig-producing chains(32%,512/1609).Most AREC isolates(99.7%,1390/1394)carried the aac(3)-Ⅳgene,conferring resistance to apramycin,gentamicin,and tobramycin.Genomic analysis of 742 AREC isolates revealed sporadic clonal transmission events between animals and humans in Qingdao and Shanghai.Long-read sequencing of 66 representative isolates showed that aac(3)-Ⅳgenes were primarily located on IncHI2/IncHI2A plasmids,with high structural conservation across different sources.Temporal surveillance indicated a sharp increase in aac(3)-Ⅳprevalence in livestock-associated E.coli following the adoption of apramycin in China.These findings demonstrate the rapid,plasmid-driven dissemination of apramycin resistance at the One Health interface,underscore the need for prudent veterinary stewardship and careful consideration of apramycin's clinical repurposing for human use. 展开更多
关键词 Apramycin resistance Escherichia coli One Health IncHI2/IncHI2A plasmids aac(3)-IV
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OGP-loaded tannic acid-stabilized gold nanoparticles mitigates bone and muscle degeneration in osteosarcopenia 认领 引用
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作者 Jiaming Wei Jiarui Xue +7 位作者 Ke Zhao Xunlu Yin Kai Sun Penghui Li Chong Liu Haojie Wang Jiawen Zhan Kexin Yang 《Metals Advances》 SCIE EI CAS CSCD 2026年第3期109-121,共13页
Osteosarcopenia,an age-related syndrome involving both bone and muscle loss,severely impairs mobility and quality of life.In this study,we constructed novel multifunctional nanomaterials,tannic acid–stabilized gold n... Osteosarcopenia,an age-related syndrome involving both bone and muscle loss,severely impairs mobility and quality of life.In this study,we constructed novel multifunctional nanomaterials,tannic acid–stabilized gold nanoparticles loaded with osteogenic growth peptide(Au@TA-OGP).The system integrates the polyphenol chemistry of tannic acid with peptide bioactivity to enable colloidally stable,biocompatible,and osteoinductive nanoparticles.Au@TA-OGP exhibited excellent cytocompatibility with macrophages and endothelial cells,while significantly enhancing osteogenic differentiation of osteoblastic cells.In an established osteosarcopenia mouse model,treatment with Au@TA-OGP restored bone microarchitecture,reduced osteoclast activity,and reduced muscle loss.Micro-CT and histological analyses revealed improved trabecular structure and reduced bone resorption and muscle histology showed enlarged myofibers with diminished fibrosis.No systemic toxicity was detected by serum biochemistry or major-organ histology.Together,these findings suggest that Au@TA-OGP provides a safe,multifunctional nanotherapy that promotes bone formation,inhibits resorption,and supports neuromuscular repair,offering translational potential for metabolic bone diseases with neuromuscular comorbidity. 展开更多
关键词 Gold nanoparticles Green synthesis Biocompatibility Osteosarcopenia Osteogenic growth peptide Ovariectomy Sciatic nerve injury
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Bacillus and lactic acid bacteria inoculation to transform kitchen waste using Hermetia illucens 认领 引用
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作者 Guoyou Deng Min Yan +5 位作者 Shengzhi Yang Lin Ji Xinfeng Han Xiumei Yu Ke Zhao Likou Zou 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第2期765-776,共12页
In this study,Bacillus mojavensis and Lactiplantibacillus herbarum were used to co-treat kitchen waste(KW)with Black soldier fly larvae(BSFL).The effects on the physicochemical properties,heavy metal content,and micro... In this study,Bacillus mojavensis and Lactiplantibacillus herbarum were used to co-treat kitchen waste(KW)with Black soldier fly larvae(BSFL).The effects on the physicochemical properties,heavy metal content,and microbial community of the BSFL sand were determined.Compared to the control group,the L.herbarum inoculation reduced 19.04%of the soluble salt(TSS),15.48%of Ni,and 13.04%of Zn in the residues;the B.mojavensis inoculation reduced 23.84%of TSS,13.61%of Pb,and 20.32%of the Ni in the residues;the L.herbarum and B.mojavensis inoculation reduced 29.53%of Cr,20.23%of Pb,18.06%of Ni,and 25.68%of the Zn in the residues.The microbial inoculants significantly enhanced the BSFL sand microbial diversity(Tukey,P<0.05).The dominant phylum and genus in the BSFL sand were Firmicutes(53.08%)and Corynebacterium(47.01%),respectively.The microbial inoculants resulted in an approximate 12%reduction in Corynebacterium.The linear discriminant analysis effective size analysis showed that the Corynebacterium abundance was significantly reduced.The microbial inoculants significantly affected the Corynebacterium relative abundance by significantly altering the substrate TSS,moisture content,and Ni.In conclusion,the effect of B.mojavensis and L.herbarum on the BSFL treatment of KW was beneficial,and their potential should be further exploited. 展开更多
关键词 Black soldier fly Bacteria Kitchen waste Waste management
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A thermoresponsive temporary plugging agent for drilling fluids in marine gas hydrate reservoirs:Synthesis,performance,and reversible plugging mechanism 认领 引用
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作者 Jin-tang Wang Ke Zhao +4 位作者 Bo Liao Lei Liu Kai-he Lü Jin-sheng Sun Shu-qiang Shi 《China Geology》 CAS CSCD 2026年第3期553-566,共14页
During drilling in marine gas hydrate reservoirs,drilling-fluid invasion can induce hydrate dissociation,wellbore instability,and reservoir damage,thereby compromising drilling safety and reservoir protection.To addre... During drilling in marine gas hydrate reservoirs,drilling-fluid invasion can induce hydrate dissociation,wellbore instability,and reservoir damage,thereby compromising drilling safety and reservoir protection.To address the low-temperature agglomeration and limited self-unplugging capability of conventional temporary plugging agents,a water-soluble thermoresponsive temporary plugging agent(TRP)was synthesized via free-radical copolymerization.Its structural characteristics,phase-transition behavior,plugging performance,reversible unplugging capacity,and underlying mechanism were systematically investigated through laboratory experiments and low-field nuclear magnetic resonance(NMR)imaging.The results show that TRP exhibits a lower critical solution temperature(LCST)of approximately 15℃,matching the thermal conditions of marine hydrate reservoirs.Above the LCST,TRP rapidly aggregates to form a dense plugging layer,effectively suppressing drilling-fluid invasion;below the LCST,it redissolves and restores formation permeability,with a maximum permeability recovery of 96.8%.Sanddisk filtration tests further demonstrate that TRP provides more effective fluid-loss control than ultrafine CaCO3 and nano-emulsion under the tested conditions.Low-field NMR imaging directly visualizes the invasion–plugging–unplugging process.Mechanism analysis indicates that plugging originates from hydrophobic association of polymer chains above the LCST,which enhances filter cake compactness and increases the rock-surface contact angle from 41.5°to 77.4°.This reversible thermoresponsive strategy provides a practical basis for intelligent reservoir protection during deep-sea hydrate drilling. 展开更多
关键词 Natural gas hydrates Combustible ice Clean energy Unconventional energy Gas hydrate reservoir Water-based drilling fluids Thermoresponsive polymers Temporary plugging agent Mechanism analysis Low-field nuclear magnetic resonance imaging Lower critical solution temperature
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Fabrication of Ce-doped macroporous carbon fibers for efficient degradation of tetracycline by activating persulfate 认领 引用 被引量：7
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作者 Chaohai Wang Taiyang Cao +7 位作者 Zheng Lv Rongfu Peng Yanli Mao Jinhui zhang Xinfeng Zhu Junning Wang Ke Zhao Gangfu Song 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第3期480-489,I0003,共10页
Metal-organic frameworks(MOFs)and their derivatives have gained significant attention in recent years for their ability to catalyze the advanced oxidation of persulfates.Cerium-doped MOFs,in particular,have shown prom... Metal-organic frameworks(MOFs)and their derivatives have gained significant attention in recent years for their ability to catalyze the advanced oxidation of persulfates.Cerium-doped MOFs,in particular,have shown promise due to their high catalytic efficiency,practical applicability,and cost-effectiveness.However,their structure,catalytic properties,and mechanisms are not yet fully understood.ZIF-8 was chosen as the raw material to prepare cerium-doped hollow carbon nano fibers(Ce-HCNFs)using the electrostatic spinning-calcination method.The objective is to investigate the structure,catalytic performance,and catalytic mechanism of Ce-HCNFs.The results show that Ce-HCNFs catalyzed the degradation of tetracycline(TC)by persulfate up to 76.9%,Quenching experiments and electron paramagnetic resonance experiments indicate the dominant role of single-linear oxygen.Furthermore,the experiments on the influence factor and cycling demonstrate the exceptional stability and recycling capability of Ce-HCNFs in real-world water environments. 展开更多
关键词 Cerium Metal-organic frameworks Electrospinning Tetracycline Persulfate Rare earths
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Antibiotics-heavy metals combined pollution in agricultural soils:Sources,fate,risks,and countermeasures 认领 引用 被引量：3
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作者 Yuanxiang Shu Donghao Li +3 位作者 Tong Xie Ke Zhao Lu Zhou Fengxiang Li 《Green Energy & Environment》 SCIE EI CAS CSCD 2025年第5期869-897,共29页
Agricultural soil is related to food security and human health,antibiotics and heavy metals(HMs),as two typical pollutants,possess a high coexistence rate in the environmental medium,which is extremely prone to induci... Agricultural soil is related to food security and human health,antibiotics and heavy metals(HMs),as two typical pollutants,possess a high coexistence rate in the environmental medium,which is extremely prone to inducing antibiotic-HMs combined pollution.Recently,frequent human activities have led to more prominent antibiotics-HMs combined contamination in agricultural soils,especially the production and spread of antibiotic resistance genes(ARGs),heavy metal resistance genes(MRGs),antibiotic resistant bacteria(ARB),and antibiotics-HMs complexes(AMCs),which seriously threaten soil ecology and human health.This review describes the main sources(Intrinsic and manmade sources),composite mechanisms(co-selective resistance,oxidative stress,and Joint toxicity mechanism),environmental fate and the potential risks(soil ecological and human health risks)of antibiotics and HMs in agricultural soils.Finally,the current effective source blocking,transmission control,and attenuation strategies are classified for discussion,such as the application of additives and barrier materials,as well as plant and animal remediation and bioremediation,etc.,pointing out that future research should focus on the whole chain process of“source-processterminal”,intending to provide a theoretical basis and decision-making reference for future research. 展开更多
关键词 Antibiotics Heavy metals Agricultural soils Composite mechanisms Potential risks Soil remediation
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Sparse pipeline wall information-based data-driven reconstruction for solid–liquid two-phase flow in flexible vibrating pipelines 认领 引用 被引量：1
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作者 Shengpeng Xiao Chuyi Wan +6 位作者 Hongbo Zhu Dai Zhou Juxi Hu Mengmeng Zhang Yuankun Sun Yan Bao Ke Zhao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2025年第11期1885-1903,共19页
Deep-sea mineral resource transportation predominantly utilizes hydraulic pipeline methodology.Environmental factors induce vibrations in flexible pipelines,thereby affecting the internal flow characteristics.Therefor... Deep-sea mineral resource transportation predominantly utilizes hydraulic pipeline methodology.Environmental factors induce vibrations in flexible pipelines,thereby affecting the internal flow characteristics.Therefore,real-time monitoring of solid–liquid two-phase flow in pipelines is crucial for system maintenance.This study develops an autoencoder-based deep learning framework to reconstruct three-dimensional solid–liquid two-phase flow within flexible vibrating pipelines utilizing sparse wall information from sensors.Within this framework,separate X-model and F-model with distinct hidden-layer structures are established to reconstruct the coordinates and flow field information on the computational domain grid of the pipeline under traveling wave vibration.Following hyperparameter optimization,the models achieved high reconstruction accuracy,demonstrating R2values of 0.990 and 0.945,respectively.The models’robustness is evaluated across three aspects:vibration parameters,physical fields,and vibration modes,demonstrating good reconstruction performance.Results concerning sensors show that 20 sensors(0.06%of total grids)achieve a balance between accuracy and cost,with superior accuracy obtained when arranged along the full length of the pipe compared to a dense arrangement at the front end.The models exhibited a signal-to-noise ratio tolerance of approximately 27 dB,with reconstruction accuracy being more affected by sensor failures at both ends of the pipeline. 展开更多
关键词 Particles Solid-liquid two-phase flow Vibration Flexible pipelines Deep learning Reconstruction
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基于全基因组测序的大熊猫源厌氧大肠杆菌抗性与毒力基因分析 认领 引用
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作者 柳承希 邓雯文 +5 位作者 龙梅 杨盛智 韩新锋 李才武 赵珂 邹立扣 《遗传》 CAS CSCD 北大核心 2026年第2期213-226,I0001,共14页
大肠杆菌(Escherichia coli)是一种兼性厌氧菌,在大熊猫肠道中的检出率较高。本研究从13只大熊猫新鲜粪便中厌氧分离得到169株厌氧菌,其中13株大肠杆菌。通过全基因组测序及分析发现,大肠杆菌分为9个序列型(sequence type,ST),共检测到9... 大肠杆菌(Escherichia coli)是一种兼性厌氧菌,在大熊猫肠道中的检出率较高。本研究从13只大熊猫新鲜粪便中厌氧分离得到169株厌氧菌,其中13株大肠杆菌。通过全基因组测序及分析发现,大肠杆菌分为9个序列型(sequence type,ST),共检测到96种抗生素抗性基因、103种重金属抗性基因和213种毒力基因,其中mdtA、mdtB、mdtC和cusA、cusB、cusC、cusF基因在大肠杆菌中普遍存在。对其抗性与毒力基因的遗传环境进一步分析发现,mdtABC的上游存在baeS/baeR可能具有调控其表达产生抗性的能力;cusABCF上游携带铁载体相关的毒力基因fepA和entD、下游携带cusS/cusR;cusABCF上下游携带的可移动遗传元件有助于抗性基因、毒力基因的传播。本研究通过全基因组测序分析了大熊猫源厌氧大肠杆菌中存在的抗生素抗性基因、重金属抗性基因和毒力基因情况,对大熊猫的安全健康保护具有重要意义。 展开更多
关键词 大熊猫 大肠杆菌 厌氧 全基因组测序 抗性
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Locking Surface Dimensionality for Endurable Interface in Perovskite Photovoltaics 认领 引用 被引量：3
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作者 Xu Zhang Yixin Luo +10 位作者 Xiaonan Wang Ke Zhao Pengju Shi Yuan Tian Jiazhe Xu Libing Yao Jingyi Sun Qingqing Liu Wei Fan Rui Wang Jingjing Xue 《Carbon Energy》 SCIE EI CSCD 2025年第4期189-196,共8页
Surface passivation with organic ammoniums improves perovskite solar cell performance by forming 2D/quasi-2D structures or adsorbing onto surfaces.However,complexity from mixed phases can trigger phase transitions,com... Surface passivation with organic ammoniums improves perovskite solar cell performance by forming 2D/quasi-2D structures or adsorbing onto surfaces.However,complexity from mixed phases can trigger phase transitions,compromising stability.The control of surface dimensionality after organic ammonium passivation presents significant importance to device stability.In this study,we developed a poly-fluorination strategy for surface treatment in perovskite solar cells,which enabled a high and durable interfacial phase purity after surface passivation.The locked surface dimensionality of perovskite was achieved through robust interaction between the poly-fluorinated ammoniums and the perovskite surface,along with the steric hindrance imparted by fluorine atoms,reducing its reactivity and penetration capabilities.The high hydrophobicity of the poly-fluorinated surface also aids in moisture resistance of the perovskite layer.The champion device achieved a power conversion efficiency(PCE)of 25.2% with certified 24.6%,with 90% of its initial PCE retained after approximately 1200 h under continuous 1-sun illumination,and over 14,400 h storage stability and superior stability under high-temperature operation. 展开更多
关键词 interface long-term stability perovskite solar cells poly-fluorination surface modification
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Adjoint-based RCS surface sensitivity calculation for very large electrical size object 认领 引用
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作者 Jun Deng Zhenghong Gao +3 位作者 Lin Zhou Ke Zhao Jiangtao Huang Wei Zhang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第5期164-179,共16页
The primary concern in stealth aircraft design is the very large electrical size objects.However,the computational and storage requirements of these objects present significant obstacles for current highfidelity desig... The primary concern in stealth aircraft design is the very large electrical size objects.However,the computational and storage requirements of these objects present significant obstacles for current highfidelity design methods,particularly when addressing high-dimensional complex engineering design problems.To address these challenges,we developed a surface sensitivity technique based on the multilevel fast multipole algorithm(MLFMA).An access and storage of sparse partial derivative tensor was improved to significantly enhanced the computation performance.The far-field interactions of the surface sensitivity equation were realized by differential the multipole expansion.In addition,we proposed a fast far-field multiplication method to accelerate the multiplication process.The surface mesh derivative with respect to the design variables was calculated by analytical and complex variable methods,substantially improving computational efficiency.These advancements enabled the MLFMAbased surface sensitivity method to millions meshes and large-scale gradients,extending gradientbased optimization for very large electrical size problems.Test cases have verified the effectiveness of this method in optimizing very large electrical objects in terms of both accuracy and efficiency. 展开更多
关键词 Surface sensitivity Gradient MLFMA Discrete adjoint Very large electrical size RCS
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Effects of Benzene-fused Position on Photophysical Properties of Benzocoumarin-based Two-Photon Fluorescent Probes for HClO Detection 认领 引用
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作者 Minghui Geng Xuexue Ma +2 位作者 Xiayu Cheng Tongshu Zhang Ke Zhao 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2025年第2期212-221,I0040,共10页
Four benzocoumarin-based two-photon fluorescent probes(BH1-BH4)are proposed for ra-tiometric detection of hypochlorous acid(HClO)and their two-photon sensing perfor-mance are evaluated by means of time-dependent densi... Four benzocoumarin-based two-photon fluorescent probes(BH1-BH4)are proposed for ra-tiometric detection of hypochlorous acid(HClO)and their two-photon sensing perfor-mance are evaluated by means of time-dependent density func-tional theory and quadratic re-sponse theory.The effects of benzene-fused position on Stokes shift,fluorescence quantum yield and two-photon absorption are discussed comprehensively.The results show that fusing a benzene ring in coumarin can enhance Stokes shift efficiently.The benzene-fused position has important effects on these photophysical properties.The benzo[g]coumarins(BH1)and benzo[f]coumarins(BH2)derivatives have larger Stokes shifts in comparison with benzo[h]coumarins(BH3)and dihydrophenazine(BH4)derivatives.The two-photon absorp-tion of benzo[f]coumarins(BH2)derivative is much smaller than those of other benzo-coumarins derivatives.The large Stokes shift and increased two-photon action cross section can be achieved simultaneously in the dihydrophenazine(BH4)derivative.Therefore,the de-signed BH4 is expected to have superior performance for the ratiometric detection of HClO.To explore the reasons behind these effects,the intramolecular charge transfer degrees are il-lustrated quantitatively by plotting the hole-electron isosurface map,and the relation be-tween charge transfer and Stokes shift is revealed.A two-state model analysis is employed to understand two-photon absorption ability.Moreover,the fluorescence near-quenching mecha-nism of the product molecules B1 and B3 is explained by analyzing reorganization energy and Huang-Rhys factor,as well as related normal mode.Our research could contribute to the effi-cient design of ratiometric two-photon fluorescent probes with large Stokes shift and signifi-cant two-photon action cross section. 展开更多
关键词 Stokes shift Fluorescence quantum yield Two-photon absorption Benzene-fused position Benzocoumarin
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美国NSF战略导向基础研究的资助模式及启示 认领 引用 被引量：2
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作者 刘云 赵珂 +1 位作者 周文能 许红丹 《中国科学基金》 CSSCI CSCD 北大核心 2025年第5期853-862,共10页
战略导向基础研究资助体系是国家科技竞争力提升的关键。美国国家科学基金会(National Science Foundation,U.S.,NSF)作为联邦政府战略导向基础研究的主要资助机构,其经验对我国有重要借鉴价值。本研究以NSF为研究对象,从“战略规划—... 战略导向基础研究资助体系是国家科技竞争力提升的关键。美国国家科学基金会(National Science Foundation,U.S.,NSF)作为联邦政府战略导向基础研究的主要资助机构,其经验对我国有重要借鉴价值。本研究以NSF为研究对象,从“战略规划—资助方式—绩效评估”的视角解析其资助特点:(1)立法框架下多方参与式战略规划的制定,以法律规范传递国家战略意志,依托多元协商保障科学决策。(2)采用竞争性与稳定性相结合的资助方式,竞争性项目聚焦应用导向的研究,以灵活周期快速响应需求;稳定资助通过持续高强度投入,聚焦跨学科深度融合与前沿技术突破。(3)强化结果运用与绩效评估,构建战略规划与绩效评估双向互动的管理体系。最后,从强化顶层设计与跨部门协同、完善战略规划与绩效评估体系、构建竞争性与稳定性相结合的资助模式以及强化学科差异化人才培养等方面,依据NSF战略导向基础研究资助特点,提出对我国自然科学基金管理的政策建议。 展开更多
关键词 美国国家科学基金会 战略规划 绩效评估 基础研究 资助模式
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Clinical Efficacy of Modified Gegen Qinlian Decoction Combined with Probiotics in Treating Radiation Enteritis and Its Regulatory Effect on Intestinal Flora 认领 引用
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作者 Xiaofeng Miao Tong Wei +8 位作者 Haichao Guan Yufan Zhang Xiaoqin Guo Ke Zhao Xin Zhao Rongrong Chai Junsuo Duan Rui Shi Yanming Zhang 《Proceedings of Anticancer Research》 2025年第6期96-103,共8页
Objective:To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics(Clostridium butyricum live capsules)in treating radiation enteritis(RE)in tumor patients,as well as its regul... Objective:To investigate the clinical efficacy of Modified Gegen Qinlian Decoction combined with probiotics(Clostridium butyricum live capsules)in treating radiation enteritis(RE)in tumor patients,as well as its regulatory effect on the structure of intestinal flora,providing clinical evidence for the integrated traditional Chinese and Western medicine treatment of radiation enteritis.Methods:A total of 40 patients with radiation enteritis admitted to the Oncology Department of Linfen Central Hospital from September 2023 to December 2024 were selected and divided into an observation group and a control group according to the random number table method,with 20 cases in each group.The control group was treated with Clostridium butyricum live capsules,while the observation group was treated with Modified Gegen Qinlian Decoction in addition to the treatment given to the control group.Both groups received a 4-week treatment course.Intestinal function indicators and changes in intestinal flora structure were compared between the two groups before and after treatment,and clinical efficacy was evaluated.Results:After 4 weeks of treatment,the total effective rate in the observation group versus the control group was(95.00%vs 65.00%),with a statistically significant difference(P<0.05).The fecal formation rate in the observation group(85.00%vs 60.00%)was significantly higher than that in the control group,and the defecation frequency(2.15±0.42 vs 3.85±0.65)times/day was significantly lower than that in the control group,with statistically significant differences(P<0.05).After treatment,the quantities of Bifidobacterium(6.85±0.72 L vs 5.23±0.61 L)gCFU/g and Lactobacillus(6.52±0.68 L vs 4.98±0.57 L)gCFU/g in the observation group were significantly higher than those in the control group,while the quantities of Escherichia coli(4.12±0.53 L vs 5.67±0.65 L)gCFU/g and Staphylococcus(3.85±0.48 L vs 5.23±0.59 L)gCFU/g were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Clinical studies have confirmed that the synergistic treatment of radiation enteritis with Modified Gegen Qinlian Decoction and probiotics can significantly improve patients’clinical symptoms and restore the balance of intestinal flora,providing an effective regimen for clinical treatment. 展开更多
关键词 Modified Gegen Qinlian Decoction Probiotics Radiation enteritis Intestinal flora Inflammatory factors Clinical efficacy
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Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus 认领 引用 被引量：36
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作者 Haiyang Yu Yuwei Zhao +17 位作者 Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2019年第4期241-251,共11页
By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the opti... By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. 展开更多
关键词 preparation breakthrough removing
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Radiomics approach for preoperative identification of stages Ⅰ-Ⅱand Ⅲ-Ⅳ of esophageal cancer 认领 引用 被引量：24
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作者 Lei WU Cong Wang +6 位作者 Xianzheng Tan Zixuan Cheng Ke Zhao Lifen Yan Yanli Liang Zaiyi Liu Changhong Liang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2018年第4期396-405,共10页
Objective： To predict preoperative staging using a radiomics approach based on computed tomography （CT）images of patients with esophageal squamous cell carcinoma （ESCC）.Methods： This retrospective study included... Objective： To predict preoperative staging using a radiomics approach based on computed tomography （CT）images of patients with esophageal squamous cell carcinoma （ESCC）.Methods： This retrospective study included 154 patients （primary cohort： n： t 14; validation cohort： n：40） withpathologically confirmed ESCC. All patients underwent a preoperative CT scan from the neck to abdomen. Highthroughput and quantitative radiomics features were extracted from the CT images for each patient. A radiomicssignature was constructed using the least absolute shrinkage and selection operator （Lasso）. Associations betweenradiomics signature, tumor volume and ESCC staging were explored. Diagnostic performance of radiomicsapproach and tumor volume for discriminating between stages Ⅰ-Ⅱand Ⅲ-Ⅳ was evaluated and compared usingthe receiver operating characteristics （ROC） curves and net reclassification improvement （NRI）.Results= A total of 9,790 radiomics features were extracted. Ten features were selected to build a radiomicssignature after feature dimension reduction. The radiomics signature was significantly associated with ESCCstaging （P〈0.001）, and yielded a better performance for discrimination of early and advanced stage ESCC comparedto tumor volume in both the primary [area under the receiver operating characteristic curve （AUC）： 0.795 vs. 0.694,P=0.003; NRI=0.424）] and validation cohorts （AUC： 0.762 vs. 0.624, P=0.035; NRI=0.834）.Conclusions： The quantitative approach has the potential to identify stage Ⅰ-Ⅱand Ⅲ-Ⅳ ESCC beforetreatment. 展开更多
关键词 Esophageal cancer tumor staging diagnostic imaging tumor volume
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Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study 认领 引用 被引量：13
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作者 ANDan Qian Xin Wang +8 位作者 Huiru Liu Jiejie Tao Jiejie Zhou Qiong Ye Jiance Li Chuang Yang Jingliang Cheng Ke Zhao Meihao Wang 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第3期497-506,共10页
Attention deficit hyperactivity disorder（ADHD）is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamin... Attention deficit hyperactivity disorder（ADHD）is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor（DRD4） on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity（Re Ho） and functional connectivity（FC）. Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD44-repeat/4-repeat（4 R/4 R） allele（n = 30） or the DRD42-repeat（2 R） allele（n = 19）. The results showed that participants with the DRD4 2 R allele had decreased Re Ho bilaterally in the posterior lobes of the cerebellum, while Re Ho was increased in the left angular gyrus. Compared with participants carrying the DRD4 4 R/4 R allele, those with the DRD4 2 R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. 展开更多
关键词 Attention deficit hyperactivity disorder Dopamine D4 receptor Frontal-striatal-cerebellar loop Resting-state functional magnetic resonance imaging Regional homogeneity Functional connectivity
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Coupling radiomics analysis of CT image with diversification of tumor ecosystem: A new insight to overall survival in stage Ⅰ-Ⅲ colorectal cancer 认领 引用 被引量：9
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作者 Yanqi Huang Lan He +8 位作者 Zhenhui Li Xin Chen Chu Han Ke Zhao Yuan Zhang Jinrong Qu Yun Mao Changhong Liang Zaiyi Liu 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2022年第1期40-52,共13页
Objective: This study aimed to establish a method to predict the overall survival(OS) of patients with stage Ⅰ-Ⅲ colorectal cancer(CRC) through coupling radiomics analysis of CT images with the measurement of tumor ... Objective: This study aimed to establish a method to predict the overall survival(OS) of patients with stage Ⅰ-Ⅲ colorectal cancer(CRC) through coupling radiomics analysis of CT images with the measurement of tumor ecosystem diversification.Methods: We retrospectively identified 161 consecutive patients with stage Ⅰ-Ⅲ CRC who had underwent radical resection as a training cohort. A total of 248 patients were recruited for temporary independent validation as external validation cohort 1, with 103 patients from an external institute as the external validation cohort 2. CT image features to describe tumor spatial heterogeneity leveraging the measurement of diversification of tumor ecosystem, were extracted to build a marker, termed the EcoRad signature. Multivariate Cox regression was used to assess the EcoRad signature, with a prediction model constructed to demonstrate its incremental value to the traditional staging system for OS prediction.Results: The EcoRad signature was significantly associated with OS in the training cohort [hazard ratio(HR)=6.670;95% confidence interval(95% CI): 3.433-12.956;P<0.001), external validation cohort 1(HR=2.866;95% CI: 1.646-4.990;P<0.001) and external validation cohort 2(HR=3.342;95% CI: 1.289-8.663;P=0.002).Incorporating the EcoRad signature into the prediction model presented a higher prediction ability(P<0.001) with respect to the C-index(0.813, 95% CI: 0.804-0.822 in the training cohort;0.758, 95% CI: 0.751-0.765 in the external validation cohort 1;and 0.746, 95% CI: 0.722-0.770 in external validation cohort 2), compared with the reference model that only incorporated tumor, node, metastasis(TNM) system, as well as a better calibration,improved reclassification and superior clinical usefulness.Conclusions: This study establishes a method to measure the spatial heterogeneity of CRC through coupling radiomics analysis with measurement of diversification of the tumor ecosystem, and suggests that this approach could effectively predict OS and could be used as a supplement for risk stratification among stage Ⅰ-Ⅲ CRC patients. 展开更多
关键词 Radiomics tumor ecosystem spatial heterogeneity survival prediction colorectal cancer
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Midterm outcome of stapled transanal rectal resection for obstructed defecation syndrome:A single-institution experience in China 认领 引用 被引量：7
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作者 Bin Zhang Jian-Hua Ding +4 位作者 Yu-Juan Zhao Meng Zhang Shu-Hui Yin Ying-Ying Feng Ke Zhao 《World Journal of Gastroenterology》 SCIE CAS 2013年第38期6472-6478,共7页
AIM:To assess midterm results of stapled transanal rectal resection(STARR)for obstructed defecation syndrome(ODS)and predictive factors for outcome.METHODS:From May 2007 to May 2009,75 female patients underwent STARR ... AIM:To assess midterm results of stapled transanal rectal resection(STARR)for obstructed defecation syndrome(ODS)and predictive factors for outcome.METHODS:From May 2007 to May 2009,75 female patients underwent STARR and were included in the present study.Preoperative and postoperative workup consisted of standardized interview and physical examination including proctoscopy,colonoscopy,anorectal manometry,and defecography.Clinical and functional results were assessed by standardized questionnaires for the assessment of constipation constipation scoring system(CSS),Longo’s ODS score,and symptom severity score(SSS),incontinence Wexner incontinence score(WS),quality of life Patient Assessment of Constipation-Quality of Life Questionnaire(PAC-QOL),and patient satisfaction visual analog scale(VAS).Data were collected prospectively at baseline,12 and 30 mo.RESULTS:The median follow-up was 30 mo(range,30-46 mo).Late postoperative complications occurred in 11(14.7%)patients.Three of these patients required procedure-related reintervention(one diverticulectomy and two excision of staple granuloma).Although the recurrence rate was 10.7%,constipation scores(CSS,ODS score and SSS)significantly improved after STARR(P<0.0001).Significant reduction in ODS symptoms was matched by an improvement in the PAC-QOL and VAS(P<0.0001),and the satisfaction index was excellent in 25(33.3%)patients,good in 23(30.7%),fairly good in 14(18.7%),and poor in 13(17.3%).Nevertheless,the WS increased after STARR(P=0.0169).Incontinence was present or deteriorated in 8(10.7%)patients;6(8%)of whom were new onsets.Univariate analysis revealed that the occurrence of fecal incontinence(preoperative,postoperative or new-onset incontinence;P=0.028,0.000,and 0.007,respectively)was associated with the success of the operation.CONCLUSION:STARR is an acceptable procedure for the surgical correction of ODS.However,its impact on symptomatic recurrence and postoperative incontinence may be problematic. 展开更多
关键词 Colorectal surgery Constipation Stapled transanal rectal resection
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Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features 认领 引用 被引量：7
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作者 Xiaojun Yang Lei Wu +12 位作者 Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2020年第2期175-185,共11页
Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This re... Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. 展开更多
关键词 Breast cancer human epidermal growth factor receptor 2 multidetector computed tomography radiomics deep learning
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