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A Generative Steganography Based on Attraction-Matrix-Driven Gomoku Games 认领 引用
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作者 Yi Cao Kuo Zhang +2 位作者 Chengsheng Yuan Linglong Zhu Wentao Ge 《Computers, Materials & Continua》 SCIE EI 2026年第2期939-962,共24页
Generative steganography uses generative stego images to transmit secret message.It also effectively defends against statistical steganalysis.However,most existing methods focus primarily on matching the feature distr... Generative steganography uses generative stego images to transmit secret message.It also effectively defends against statistical steganalysis.However,most existing methods focus primarily on matching the feature distribution of training data,often neglecting the sequential continuity between moves in the game.This oversight can result in unnatural patterns that deviate from real user behavior,thereby reducing the security of the hidden communication.To address this issue,we design a Gomoku agent based on the AlphaZero algorithm.The model engages in self-play to generate a sequence of plausible moves.These moves formthe basis of the stego images.We then apply an attractionmatrix at each step.It guides themove selection so that themoves appearmore natural.Thismethod helps maintain logical flow between moves.It also extends the game length,which increases the embedding capacity.Next,we filter and prioritize the generated moves.The selected moves are embedded into a move pool.Secret message is mapped to thesemoves.It is then embedded step by step as the game progresses.The finalmove sequence constitutes a complete steganographic game record.The receiver can extract the secret message using this record and a predefined mapping rule.Experiments show that our method reaches a maximum embedding capacity of 223 bits per carrier.Detection accuracy is 0.500 under XuNet and 0.498 under YeNet.These results are equal to random guessing,showing strong imperceptibility.The proposed method demonstrates superior concealment,higher embedding capacity,and greater robustness against common image distortions and steganalysis attacks. 展开更多
关键词 Generative steganography information hiding steganography steganalsis attraction matrix
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Single crystal NCM811 cathode material prepared by rapid solvothermal method 认领 引用
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作者 Li-xing XUE Hong-yan PAN +6 位作者 Yu-jie WANG Wei YANG Yue-jun WANG Xiang-nan BU Qian LIN Kuo ZHANG Liang-xing JIANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第6期1860-1874,共15页
To achieve large-scale application of solvothermal method and settle structural collapse of polycrystalline ternary NCM cathode materials(LiNi0.8Co0.1Mn0.1O2,NCM811)during long charge and discharge cycling,single-crys... To achieve large-scale application of solvothermal method and settle structural collapse of polycrystalline ternary NCM cathode materials(LiNi0.8Co0.1Mn0.1O2,NCM811)during long charge and discharge cycling,single-crystalline NCM materials with high cycling stability were prepared by rapid ethanol-water solvothermal method.The morphology and electrochemical properties of NCM materials were characterized by X-ray diffractometry,cross-section scanning electron microscopy,transmission electron microscopy,X-ray photoelectron spectroscopy,and electrochemical measurement.The results show that single-crystalline NCM synthesized with 60 min solvothermal time has the most excellent electrochemical performance.Its reversible capacity reaches 157.28 mA·h/g at 1C and retention rate achieves 55.06%after 200 cycles,which is much better than the polycrystalline NCM cathode material.Cross-section scanning electron microscopy results show that the single-crystalline NCM cathode material has no apparent cracks after 200 cycles. 展开更多
关键词 lithium-ion battery LiNi0.8Co0.1Mn0.1O2 single-crystalline structure rapid solvothermal method
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Recent applications of EEG-based brain-computer-interface in the medical field 认领 引用 被引量：29
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作者 Xiu-Yun Liu Wen-Long Wang +39 位作者 Miao Liu Ming-Yi Chen Tânia Pereira Desta Yakob Doda Yu-Feng Ke Shou-Yan Wang Dong Wen Xiao-Guang Tong Wei-Guang Li Yi Yang Xiao-Di Han Yu-Lin Sun Xin Song Cong-Ying Hao Zi-Hua Zhang Xin-Yang Liu Chun-Yang Li Rui Peng Xiao-Xin Song Abi Yasi Mei-Jun Pang Kuo Zhang Run-Nan He Le Wu Shu-Geng Chen Wen-Jin Chen Yan-Gong Chao Cheng-Gong Hu Heng Zhang Min Zhou Kun Wang Peng-Fei Liu Chen Chen Xin-Yi Geng Yun Qin Dong-Rui Gao En-Ming Song Long-Long Cheng Xun Chen Dong Ming 《Military Medical Research》 SCIE CAS CSCD 2025年第8期1283-1322,共40页
Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BC... Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility. 展开更多
关键词 Brain-computer interfaces(BCIs) Medical applications Rehabilitation Communication Brain monitoring Diagnosis
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Heart-brain axis:low blood pressure during off-pump CABG surgery is associated with postoperative heart failure 认领 引用
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作者 Xiu-Yun Liu Jing-Jing Mu +7 位作者 Jian-Ge Han Mei-Jun Pang Kuo Zhang Wen-Qian Zhai Nan Su Guang-Jian Ni Zhi-Gang Guo Dong Ming 《Military Medical Research》 SCIE CAS CSCD 2025年第5期799-802,共4页
Dear Editor,The primary objective of the letter is to emphasize the importance of personalized management of arterial blood pressure(ABP)in the context of off-pump coronary artery bypass grafting(CABG)surgery.Coronary... Dear Editor,The primary objective of the letter is to emphasize the importance of personalized management of arterial blood pressure(ABP)in the context of off-pump coronary artery bypass grafting(CABG)surgery.Coronary artery disease,a leading global cause of mortality,necessitates a substantial number of cardiac surgeries,with approximately 400,000 CABG operations conducted annually in the United States.Postoperative heart failure(HF)is a common occurrence after CABG surgery,with readmission rates within 30 d due to HF ranging from 12% to 16%. 展开更多
关键词 Off-pump coronary artery bypass grafting(CABG) Heart failure(HF) Individualized arterial blood pressure(ABP)management Cerebral autoregulation(CA) Optimal ABP
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Artificial intelligence empowering the full spectrum of drug discovery 认领 引用
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作者 Tingting Fu Kuo Zhang +2 位作者 Tingjun Hou Caisheng Wu Feng Zhu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第8期1687-1689,共3页
Drug discovery is a complex and highly systematic process encompassing multiple critical stages,including target identification,bioactive molecule discovery,preclinical research,clinical trials,regulatory review,post-... Drug discovery is a complex and highly systematic process encompassing multiple critical stages,including target identification,bioactive molecule discovery,preclinical research,clinical trials,regulatory review,post-marketing surveillance,and others[1].This process typically spans many years and is often accompanied by high failure rates and substantial resource consumption.In recent years,driven by large amounts of biomedical data,artificial intelligence(AI)has begun to reshape every stage of drug discovery[2].Particularly,by integrating diverse,high-dimensional datasets with powerful predictive and generative models. 展开更多
关键词 clinicaltrials drugdiscovery drug discovery target identificationbioactive molecule discoverypreclinical researchclinical trialsregulatory targetidentification bioactive moleculediscovery biomedical dataartificial intelligence ai preclinicalresearch
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Acoustic reflection well logging modeling using the frequency-domain finite-element method with a hybrid PML 认领 引用 被引量：6
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作者 Wang Bing Kuo Zhang +2 位作者 Guo Tao He Liu Zhang Xiao-Liang 《Applied Geophysics》 SCIE CSCD 2018年第1期35-45,148,共11页
In this paper, we propose a hybrid PML （H-PML） combining the normal absorption factor of convolutional PML （C-PML） with tangential absorption factor of Mutiaxial PML （M-PML）. The H-PML boundary conditions can be... In this paper, we propose a hybrid PML （H-PML） combining the normal absorption factor of convolutional PML （C-PML） with tangential absorption factor of Mutiaxial PML （M-PML）. The H-PML boundary conditions can better suppress the numerical instability in some extreme models, and the computational speed of finite-element method and the dynamic range are greatly increased using this HPML. We use the finite-element method with a hybrid PML to model the acoustic reflection of the interface when wireline and well logging while drilling （LWD）, in a formation with a reflector outside the borehole. The simulation results suggests that the PS- and SP- reflected waves arrive at the same time when the inclination between the well and the outer interface is zero, and the difference in arrival times increases with increasing dip angle. When there are fractures outside the well, the reflection signal is clearer in the subsequent reflection waves and may be used to identify the fractured zone. The difference between the dominant wavelength and the model scale shows that LWD reflection logging data are of higher resolution and quality than wireline acoustic reflection logging. 展开更多
关键词 Frequency domain finite-element method hybrid PML boundary wireline well logging logging while drilling
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In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition 认领 引用 被引量：4
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作者 Ziming Chen Kuo Zhang +8 位作者 Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第12期3107-3112,共6页
Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,α... Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy. 展开更多
关键词 Self-assembly Integrinαvβ3 Peptide Anti-angiogenesis Tumor
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Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction 认领 引用 被引量：3
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作者 Wen-Yao WANG Kuo ZHANG +3 位作者 Wei ZHAO A. Martin Gerdes Giorgio Iervasi Yi-Da TANG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第4期290-297,共8页
Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role i... Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment. 展开更多
关键词 Acute myocardial infarction Free triiodothyronine Hypothyroid Statin
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Advanced all-optical classification using orbitalangular-momentum-encoded diffractive networks 认领 引用 被引量：8
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作者 Kuo Zhang Kun Liao +2 位作者 Haohang Cheng Shuai Feng Xiaoyong Hu 《Advanced Photonics Nexus》 2023年第6期51-64,共14页
As a successful case of combining deep learning with photonics,the research on optical machine learning has recently undergone rapid development.Among various optical classification frameworks,diffractive networks hav... As a successful case of combining deep learning with photonics,the research on optical machine learning has recently undergone rapid development.Among various optical classification frameworks,diffractive networks have been shown to have unique advantages in all-optical reasoning.As an important property of light,the orbital angular momentum(OAM)of light shows orthogonality and mode-infinity,which can enhance the ability of parallel classification in information processing.However,there have been few all-optical diffractive networks under the OAM mode encoding.Here,we report a strategy of OAM-encoded diffractive deep neural network(OAM-encoded D2NN)that encodes the spatial information of objects into the OAM spectrum of the diffracted light to perform all-optical object classification.We demonstrated three different OAM-encoded D2NNs to realize(1)single detector OAM-encoded D2NN for single task classification,(2)single detector OAM-encoded D2NN for multitask classification,and(3)multidetector OAM-encoded D2NN for repeatable multitask classification.We provide a feasible way to improve the performance of all-optical object classification and open up promising research directions for D2NN by proposing OAMencoded D2NN. 展开更多
关键词 diffractive deep neural network deep learning orbital angular momentum multiplexing optical classification
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Recent advances of transformable nanoparticles for theranostics 认领 引用 被引量：4
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作者 Kuo Zhang Pei-Pei Yang +2 位作者 Jing-Ping Zhang Lei Wang Hao Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第9期1808-1816,共9页
In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their be... In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical applications.The sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention etc.The other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases.Herein,we summarized recent advances of transformable NPs for disease diagnostics and therapy.In this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature etc.Moreover,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease. 展开更多
关键词 Transformable Nanoparticles Tumor Imaging Therapy
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The analgesic effect of electroacupuncture in complete Freund's adjuvant rats:a meta analysis 认领 引用
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作者 Kuo ZHANG Zhi-fang XU +4 位作者 Kai LI Xue ZHAO Bo CHEN Yi GUO Shen-jun WANG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2019年第1期15-27,共13页
Pain is a global problem and has been found sensitive to acupuncture. A large number of existing and newly published studies have demonstrated the analgesic effect of electroacupuncture(EA) in complete Freund's ad... Pain is a global problem and has been found sensitive to acupuncture. A large number of existing and newly published studies have demonstrated the analgesic effect of electroacupuncture(EA) in complete Freund's adjuvant(CFA) rat model, necessitating a new and comprehensive review. To evaluate the curative effect of EA on thermal hyperalgesia in CFA rats, and to explore parameters that influence treatment effects, studies of EA treatment on thermal hyperalgesia of CFA rat model were identified from nine databases up to June 17, 2017. Outcome measure was heat pain threshold. All the data were analyzed using Stata 14.0/MP software. 26 studies identified included 801 rats. The quality score of the studies ranged from 3 to 6, with a mean of 4.08. The effect of EA group was improvement in outcome compared with CFA group. In subgroup analyses, frequency 2, 100, 2/100 or 20-100 Hz. acupoint Huántiào(环跳GB30),Kūnlún(昆仑 BL60) +Xuánzhōng(悬钟 GB39), Zúsānlī(足三里 ST36) +BL60 or ST36+Sānyīnjiāo(三阴交SP6), retention time 20 or 30 min, treatment time for post-CFA injection immediately, the same day as CFA injection, post-CFA injection 24 or 48 h and interval 24 or 48 h all can improve the effect on CFA rat heat pain threshold. These results show that there is positive effective of EA in CFA-induced pain,different parameters have different effects on EA treatment of CFA heat hyperalgesia, however, because of the number of eligible researches and the high risk of bias, the evidence supporting this conclusion is limited. 展开更多
关键词 Electroacupuncture(EA) Analgesia Complete Freund's adjuvant Rats
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KLVFF peptide functionalized nanoparticles capture Aβ42 by co-assembly for decreasing cytotoxicity 认领 引用
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作者 Peipei Yang Chao Yang +2 位作者 Kuo Zhang Lei Wang Hao Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第12期1811-1814,共4页
The accumulation of extracellular senile plagues of amyloid β-proteins(Aβ) in the patient brain is one of most important facture in Alzheimer’s disease(AD), which is resulted from abnormal self-assembly of Aβpepti... The accumulation of extracellular senile plagues of amyloid β-proteins(Aβ) in the patient brain is one of most important facture in Alzheimer’s disease(AD), which is resulted from abnormal self-assembly of Aβpeptide. Nanoparticles show greatly potential for therapeutic studies due to the sophisticated surface which can mimic the functionality of protein. Herein, we design the bis(pyrene)-Lys-Leu-Val-Phe-PheGly-poly ethylene glycol(BP-KLVFFGPEG) based nanoparticles, which capture Aβthrough recognition and co-assembly of KLVFF. The resulting co-assemblies show different morphologies, such as large aggregates, nanoparticles and nanofibers corresponding to the different length chain of PEG, leading to different capture efficiencies. The co-assembly strategy shows a decrease of cytotoxicity, potentially for AD treatment. 展开更多
关键词 Co-assembly Morphology Capture Nanoparticles Aβ
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Uric acid is associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy 认领 引用
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作者 Jun GAO Chun-Li SHAO +5 位作者 Xiang-Bin MENG Wen-Yao WANG Kuo ZHANG Jing-Jia WANG Ming-Qi ZHENG Yi-Da TANG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2021年第4期281-288,共8页
BACKGROUND The role of uric acid(UA) in survival of patients with hypertrophic obstructive cardiomyopathy(HOCM) has not been fully evaluated. This study aimed to determine whether UA could be an independent risk facto... BACKGROUND The role of uric acid(UA) in survival of patients with hypertrophic obstructive cardiomyopathy(HOCM) has not been fully evaluated. This study aimed to determine whether UA could be an independent risk factor of cardiac death in patients with HOCM.METHODS A total of 317 patients with HOCM, who were receiving conservative treatment in Fuwai Hospital from October2009 to December 2014, all of them completed UA evaluations, were analyzed. Patients were divided into three groups according to the UA levels: Tertile 1(≤ 318 μmol/L, n = 106), Tertile 2(319 to 397 μmol/L, n = 105), and Tertile 3(≥ 398 μmol/L, n = 106).RESULTS During a median follow-up of 45 months, 29 cardiac deaths(9.1%) occurred, including 6 sudden cardiac deaths and23 heart failure-related deaths. Cardiac death in Tertile 3(n = 16, 55.2%) was significantly higher than in Tertile 1(n = 6, 20.7%)and Tertile 2(n = 7, 24.1%). In univariate model, UA level(continuous value) showed predictive value of cardiac death [hazard ratio(HR) = 1.006, 95% CI: 1.003-1.009, P = 0.009]. Univariate Cox survival analysis had shown a significant higher property of cardiac death in patients of Tertile 3 when compared with those of Tertile 1, but cardiac death in patients of Tertile 2 did not show significant prognositic value compared with those of Tertile 1(HR = 3.927, 95% CI: 0.666-23.162, P = 0.131). UA was found to be an independent risk factor(HR = 1.005, 95% CI: 1.001-1.009, P = 0.009) of cardiac death in the multivariate regression analysis after the adjustment for age, body mass index, atrial fibrillation, hemoglobin, creatinine, high-sensitivity C-reactive protein, interventricular septum/left ventricular posterior wall ratio, left ventricular outflow tract and left ventricular ejection fraction.CONCLUSIONS UA concentration was found to be independently associated with cardiac death in HOCM patients receiving conservative treatment. Randomized trials of UA-lowering agents for HOCM patients are warranted. 展开更多
关键词 CRP Uric acid is associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy
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Study of the numerical simulation of tight sandstone gas molecular diffusion based on digital core technology 认领 引用 被引量：4
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作者 Hong-Lin Zhu Shou-Feng Wang +5 位作者 Guo-Jun Yin Qiao Chen Feng-Lin Xu Wei Peng Yan-Hu Tan Kuo Zhang 《Petroleum Science》 SCIE CAS CSCD 2018年第1期68-76,共9页
Diffusion is an important mass transfer mode of tight sandstone gas. Since nano-pores are extensively developed in the interior of tight sandstone, a considerable body of research indicates that the type of diffusion ... Diffusion is an important mass transfer mode of tight sandstone gas. Since nano-pores are extensively developed in the interior of tight sandstone, a considerable body of research indicates that the type of diffusion is mainly molecular diffusion based on Fick＇s law. However, accurate modeling and understanding the physics of gas transport phenomena in nanoporous media is still a challenge for researchers and traditional investigation（analytical and experimental methods） have many limitations in studying the generic behavior. In this paper, we used Nano-CT to observe the pore structures of samples of the tight sandstone of western of Sichuan. Combined with advanced image processing technology, threedimensional distributions of the nanometer-sized pores were reconstructed and a tight sandstone digital core model was built, as well the pore structure parameters were analyzed quantitatively. Based on the digital core model, the diffusion process of methane molecules from a higher concentration area to a lower concentration area was simulated by a finite volume method. Finally, the reservoir＇s concentration evolution was visualized and the intrinsic molecular diffusivity tensor which reflects the diffusion capabilities of this rock was calculated. Through comparisons, we found that our calculated result was in good agreement with other empirical results. This study provides a new research method for tight sandstone digital rock physics. It is a foundation for future tight sandstone gas percolation theory and numerical simulation research. 展开更多
关键词 Tight sandstone gas Nano-CT Digital core Molecular diffusion Numerical simulation
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Assessment of causal direction between thyroid function and cardiometabolic health:a Mendelian randomization study 认领 引用 被引量：6
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作者 Jing-Jia WANG Zhen-Huang ZHUANG +11 位作者 Can-Qing YU Wen-Yao WANG Wen-Xiu WANG Kuo ZHANG Xiang-Bin MENG Jun GAO Jian TIAN Ji-Lin ZHENG Jie YANG Tao HUANG Chun-Li SHAO Yi-Da TANG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2022年第1期61-70,共10页
BACKGROUND Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism.However,the causal relationship of thyroid function and cardiometabolic health remai... BACKGROUND Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism.However,the causal relationship of thyroid function and cardiometabolic health remains partly unknown.METHODS The Mendelian randomization(MR)was used to test genetic,potentially causal relationships between instrumental variables and cardiometabolic traits.Genetic variants of free thyroxine(FT4)and thyrotropin(TSH)levels within the reference range were used as instrumental variables.Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen,CARDIoGRAM and CARDIoGRAMplusC4D,CHARGE,and MEGASTROKE.This study was conducted using summary statistic data from large,previously described cohorts.Association between thyroid function and essential hypertension(EHTN),secondary hypertension(SHTN),hyperlipidemia(HPL),type 2 diabetes mellitus(T2DM),ischemic heart disease(IHD),myocardial infarction(MI),heart failure(HF),pulmonary heart disease(PHD),stroke,and non-rheumatic valve disease(NRVD)were examined.RESULTS Genetically predicted FT4 levels were associated with SHTN(odds ratio=0.48;95%CI=0.04−0.82,P=0.027),HPL(odds ratio=0.67;95%CI=0.18−0.88,P=0.023),T2DM(odds ratio=0.80;95%CI=0.42−0.86,P=0.005),IHD(odds ratio=0.85;95%CI=0.49−0.98,P=0.039),NRVD(odds ratio=0.75;95%CI=0.27−0.97,P=0.039).Additionally,genetically predicted TSH levels were associated with HF(odds ratio=0.82;95%CI=0.68−0.99,P=0.042),PHD(odds ratio=0.75;95%CI=0.32−0.82,P=0.006),stroke(odds ratio=0.95;95%CI=0.81−0.97,P=0.007).However,genetically predicted thyroid function traits were not associated with EHTN and MI.CONCLUSIONS Our study suggests FT4 and TSH are associated with cardiometabolic diseases,underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility. 展开更多
关键词 cardio function random
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Metallogenesis and ore-forming time of the Changtuxili Mn-Ag-Pb-Zn deposit in Inner Mongolia:Evidence from C-O-S isotopes and U-Pb geochronology 认领 引用 被引量：3
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作者 Kuo Zhang Ruo-Shi Jin +5 位作者 Feng-Yue Sun Bi-Le Li Peng He Yue-Long Zhang Shuo Guo Tian-Fu Zhang 《Geoscience Frontiers》 SCIE CAS CSCD 2020年第4期1369-1380,共12页
This paper reports new geochronological(U-Pb) and isotope(C,O,and S) data to investigate the timing of mineralization and mode of ore genesis for the recently discovered Changtuxili Mn-Ag-Pb-Zn deposit,located on the ... This paper reports new geochronological(U-Pb) and isotope(C,O,and S) data to investigate the timing of mineralization and mode of ore genesis for the recently discovered Changtuxili Mn-Ag-Pb-Zn deposit,located on the western slopes of the southern Great Hinggan Range in NE China.The mineralization is hosted by intermediate-acidic lavas and pyroclastic rocks of the Baiyingaolao Formation.Three stages of mineralization are identified:quartz-pyrite(Stage I),galena-sphalerite-tetrahedrite-rhodochrosite(Stage II),and quartz-pyrite(Stage Ⅲ).δ13C and δ18O values for carbonate from the ore vary from-8.51‰ to-4.96‰ and 3.97‰ to 15.90‰,respectively,which are indicative of a low-temperature alteration environment.δ34SV-CDT values of sulfides range from-1.77‰ to 4.16‰ and show a trend of equilibrium fractionation(δ34SPy>δ34SSp>δ34SGn).These features indicate that pyrite,sphalerite,and galena precipitated during the period of mineralization.The alteration mineral assemblage and isotope data indicate that the weakly acidic to weakly alkaline ore-forming fluid was derived largely from meteoric water and the ore-forming elements C and S originated from magma.During the mineralization,a geochemical barrier was formed by changes in the pH of the ore-forming fluid,leading to the precipitation of rhodochrosite.On the basis of the mineralization characteristics,new isotope data,and comparison with adjacent deposits,we propose that the Changtuxili Mn-Ag-Pb-Zn deposit is an intermediate-to lowsulfidation epithermal deposit whose formation was controlled by fractures and variability in the pH of the oreforming fluid.The surrounding volcanic rocks yield zircon U-Pb ages of 160-146 Ma(Late Jurassic),indicating that the mineralization is younger than 146 Ma. 展开更多
关键词 Inner Mongolia Changtuxili Mn-Ag-Pb-Zn deposit C-O-S isotope geochemistry Zircon U-Pb age Intermediate-to low-sulfidation epithermal deposit
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Y Zeolites Modified by Organosilane for Toluene Adsorption under High Humidity Condition 认领 引用 被引量：1
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作者 Boyu Zhang Kuo Zhang +2 位作者 Ziqiang Duan Jianping Zhu Junan Gao 《American Journal of Analytical Chemistry》 CAS 2023年第10期451-466,共16页
Y zeolites have moderate microporous pore size, large specific surface area, and good hydrothermal stability, which were widely used in industrial adsorption of volatile organic compounds (VOCs), but the performance o... Y zeolites have moderate microporous pore size, large specific surface area, and good hydrothermal stability, which were widely used in industrial adsorption of volatile organic compounds (VOCs), but the performance of Y zeolites in adsorption of VOCs under high humidity conditions is terrible. In this paper, Y zeolites with different silica-alumina ratios were hydrophobically modified by organosilane and characterized by XRD, FTIR, SEM, BET, NMR. In the experiments of static and dynamic adsorption of VOCs by modified Y zeolites, it can be concluded that the static water adsorption capacity of Y zeolites with silica-aluminum ratio of 5 and 40 after silica modification decreased by 62 wt% and 53 wt%, under the conditions of high humidity, GHSV = 15,000 h-1, T = 35°C and initial concentration of toluene C0 = 5000 mg·m-3. The saturation adsorption capacity of toluene was increased from 0.06 g·g-1, 0.09 g·g-1 to 0.15 g·g-1, 0.21 g·g-1, the adsorption selectivity of Y zeolites for water was reduced and that for toluene was increased after Vapor phase silanization overlay modification. The present modification method might carry out targeted modification of zeolites surface, provide research ideas and guidance under high humidity conditions. 展开更多
关键词 Y Zeolites Hydrophobic Modification Volatile Organic Compounds Toluene
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Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin 认领 引用 被引量：1
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作者 Yi-Jing Li Lingze Zhang +7 位作者 Ming-Hao Pang Pei-Pei Yang Lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第3期384-388,共5页
Peptide drugs are known for their high biological safety.However,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in half-life.Herein,inspired by the long circulatio... Peptide drugs are known for their high biological safety.However,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in half-life.Herein,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide drugs.Beads displaying random peptides were screened using fluorescent labeled human serum albumin.Fluorescent beads with specific binding to albumin were isolated for sequencing.The selected ABPs can effectively bind to albumin,thus possessing the long circulation of albumin.The dissociation constant(KD)of ABPs to albumin is up to 1×10-8mol/L.Once one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in mice.The OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs. 展开更多
关键词 One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin
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A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis 认领 引用 被引量：1
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作者 Shifang Wen Kuo Zhang +5 位作者 Yuan Li Jiaqi Fan Ziming Chen Jjingping Zhang Hao Wang Lei Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第12期3153-3157,共5页
Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and metastasis.Studies on anti-angiogenic therapy have been mostly focused... Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and metastasis.Studies on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR pathways.We report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix(ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR interactions.The transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in solution.In addition,the transformable peptide-based nanomate rial forms ECM-like fibrous netwo rks on VEGFR overexpressed cells,inhibiting the VEGF-VEGFR interactions and the subsequent angiogenesis.The tube formation is reduced by nearly 85.1% after treatment.This strategy shows excellent potential for anti-angiogenesis,and inhibition of tumor invasion and metastasis. 展开更多
关键词 Self-assembly Peptide VEGF Angiogenesis Biomimetic
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Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice 认领 引用
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作者 Guixiang Wang Wenjia Wang +7 位作者 Ye Zhang Xiaoying Gou Qingqing Zhang Yanmiao Huang Kuo Zhang Haotian Zhang Jingyu Yang Yuting Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期416-424,共9页
Adolescent binge drinking leads to long-lasting disorders of the adult central nervous system,particularly aberrant hippocampal neurogenesis.In this study,we applied in vivo fluorescent tracing using NestinCreERT2::Ro... Adolescent binge drinking leads to long-lasting disorders of the adult central nervous system,particularly aberrant hippocampal neurogenesis.In this study,we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells(NSCs)and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus.We found abnormal orientation of tamoxifen-induced tdTomato+(tdTom+)NSCs in adult mice 2 months after treatment with EtOH(5.0 g/kg,i.p.)for 7 consecutive days.EtOH markedly inhibited tdTom+NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood.EtOH(100 mM)also significantly inhibited the proliferation to 39.2%and differentiation of primary NSCs in vitro.Adult mice exposed to EtOH also exhibited marked inhibitions in dendritic spine growth and newborn neuron maturation in the dentate gyrus,which was partially reversed by voluntary running or inhibition of the mammalian target of rapamycinenhancer of zeste homolog 2 pathway.In vivo tracing revealed that EtOH induced abnormal orientation of tdTom+NSCs and spatial misposition defects of newborn neurons,thus causing the disturbance of hippocampal neurogenesis and dendritic spine remodeling in mice. 展开更多
关键词 adolescence adulthood ethanol dentate gyrus EZH2 in vivo tracing lineage progression mTOR neural stem cell newborn dendritic spine newborn neurons
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