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Future changes in ozone and oxidation capacity in China under the carbon peaking policy:The role of emissions and meteorology 认领 引用
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作者 Ao Shen Yiming Liu +3 位作者 Yuqi Zhu Xiao Lu Qi Fan Lei Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期504-515,共12页
Future ozone(O₃)pollution in China is shaped by complex interactions between emission reductions and meteorological changes under China’s carbon peaking and neutrality targets.This study employs the WRF-CMAQ modeling... Future ozone(O₃)pollution in China is shaped by complex interactions between emission reductions and meteorological changes under China’s carbon peaking and neutrality targets.This study employs the WRF-CMAQ modeling system with process analysis to quantify the impacts of meteorology and emissions on O₃and atmospheric oxidation capacity(AOC)across major Chinese regions in 2030.Under the carbon peaking scenario,wintertime O₃concentration increases across most regions,while summertime daytime O₃decreases except in the Yangtze River Delta(YRD).Nighttime O₃generally increases across all regions,and overall AOC is enhanced,particularly in summer.Disentangling the roles of meteorology and emissions shows that,although meteorological changes alone would reduce O₃in winter through enhanced dilution and limited photochemical activity,the effect of emission reductions dominates by weakening the nitric oxide(NO)titration effect,resulting in a net O₃increase.In summer,daytime emission reductions weaken NO titration,while higher humidity suppresses O₃formation,except in the YRD,where reduced humidity promotes O₃production.At night,stronger winds enhance vertical mixing and promote the downward transport of O₃from the residual layer,and the reduced NO titration effect further increases O₃levels.These findings underscore the importance of targeted mitigation strategies that account for the distinct seasonal and regional responses of O₃and AOC to both emission and meteorological changes under future climate and policy scenarios. 展开更多
关键词 Ozone Atmospheric oxidation capacity Carbon peaking policy WRF-CMAQ Process analysis
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A three–in–one strategy to prepare a ternary CoS2/FeS2/Ti3C2Tx catalyst for oxygen evolution reaction in water–splitting devices 认领 引用
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作者 Liang Chen Yun Peng +6 位作者 Xin-Rui Li Chen-Xi Xu Qing Zeng Lei Li Yang-Yang Chen Wei Wang Zhao-Hui Hou 《Metals Advances》 SCIE EI CAS CSCD 2026年第7期101-107,共7页
Transition metal sulfides(TMSs)are widely recognized as promising catalysts for the oxygen evolution reaction(OER),yet their large–scale application is hindered by poor conductivity,severe aggregation and sluggish re... Transition metal sulfides(TMSs)are widely recognized as promising catalysts for the oxygen evolution reaction(OER),yet their large–scale application is hindered by poor conductivity,severe aggregation and sluggish reaction kinetics.To address these issues,a ternary CoS2/FeS2/Ti3C2Tx hybrid is rationally constructed via a three–in–one strategy,which simultaneously achieves the support introduction,morphology modulation and heterojunction construction.Structural characterizations reveal a hierarchical architecture composed of 1D CoS2 nanorods,0D FeS2 nanoparticles and 2D conductive Ti3C2Tx nanosheets,wherein CoS2 and FeS2 form a distinctive 1D/0D heterojunction.Density functional theory calculations demonstrate that strong electronic coupling at the CoS2/FeS2 heterointerface accelerates electron transfer and optimizes the adsorption behavior of oxygen intermediates.Benefiting from the synergistic effects between the CoS2/FeS2 heterojunction and the conductive Ti3C2Tx support,the as–prepared CoS2/FeS2/Ti3C2Tx hybrid exhibits elevated conductivity,promoted dispersibility and accelerated reaction kinetics,thus resulting in markedly improved OER performance as compared to the control samples.Additionally,the CoS2/FeS2/Ti3C2Tx hybrid presents a remarkably low overpotential of 284 mV when used as the anode catalyst in a water–splitting device,demonstrating its outstanding applicability for overall water electrolysis.Overall,this work provides a viable strategy for engineering high–performance TMS–based electrocatalysts through heterointerface design and conductive support integration. 展开更多
关键词 Transition metal sulfides CoS2/FeS2/Ti3C2Tx 1D/0D heterojunction Oxygen evolution reaction Water–splitting devices
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A novel scaling method for the elastic ring supporting structure of an aero-engine rotor system: analytical and experimental investigations 认领 引用
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作者 Lei LI Tianyue MA +4 位作者 Zhong LUO Dongwu GAO Xiangdong GE Hui MA Shibin WANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第1期1-18,共18页
The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometr... The testing of large structures is limited by high costs and long cycles, making scaling methods an attractive solution. However, the scaling process of elastic rings introduces complexities in multi-parameter geometric distortions, leading to a diminution in the predictive accuracy of the distorted similitude. To address this challenge, this study formulates a novel set of scaling laws, tailored to account for the intricate geometric distortions associated with elastic rings. The proposed scaling laws are formulated based on the intrinsic deformation characteristics of elastic rings, rather than the traditional systemic governing equations. Numerical and experimental cases are conducted to assess the efficacy and precision of the proposed scaling laws, and the obtained results are compared with those achieved by traditional methods. The outcomes demonstrate that the scaling laws put forth by this study significantly enhance the predictive capabilities for deformations of elastic rings. 展开更多
关键词 rotor system aero-engine elastic ring scaling method supporting structure
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Hybrid Deep Learning for Hydraulic Cylinder Fault Diagnosis under Complex Conditions via Multi-Source Signal Fusion 认领 引用
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作者 Chen Yang Jianwen Yan +2 位作者 Yixiong Feng Lei Li Jianrong Tan 《Instrumentation》 2026年第1期40-56,共17页
Hydraulic presses are indispensable in automotive and aerospace manufacturing,with hydraulic cylinders serving as key components for operational safety and product quality.Internal leakage faults in hydraulic cylinder... Hydraulic presses are indispensable in automotive and aerospace manufacturing,with hydraulic cylinders serving as key components for operational safety and product quality.Internal leakage faults in hydraulic cylinders are difficult to diagnose due to the scarcity of labeled data,the complexity of fault mechanisms,and the limited representation capability of single-signal methods under variable operating conditions.To address these issues,a hybrid deep learning feature fusion model based on displacement error and pressure signal,including convolutional autoencoder,multi-head attention mechanism,residual network and bidirectional long short time series neural network(CAEMRAB),is proposed for the diagnosis and classification of leakage faults in hydraulic cylinders.A hydraulic cylinder test system simulates heavy load,variable speed,and nonlinear motion under actual operating conditions.Through the all-round deep feature decoupling of the proposed model,the multi-source signal representation ability in complex and multi-noise environments is enhanced,effectively extracting the local and global features of displacement error and pressure signal fault data and achieving efficient classification.Experimental results indicate that the proposed model achieves at least a 3.95%improvement in diagnostic accuracy compared with ablation models.In addition,it exhibits high diagnostic stability across other models,single-signal diagnosis,varying sample sizes,and complex noise conditions.These experiments fully validate the superior performance of the proposed method in terms of diagnostic accuracy,reliability,and robustness. 展开更多
关键词 hydraulic cylinder feature fusion multi-source signal hybrid deep learning deep feature decoupling
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Cell-free DNA in sepsis:from molecular insights to clinical management 认领 引用 被引量：1
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作者 Lei Li Hong-Chao Huang +4 位作者 Yin He Jia-Yue-Cheng Pang Shi-Chu Xiao Zhao-Fan Xia Yong-Jun Zheng 《Military Medical Research》 SCIE CAS CSCD 2026年第5期766-810,共45页
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction.Despite advances in clinical identification and management,both its incidence and mortality have remained... Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction.Despite advances in clinical identification and management,both its incidence and mortality have remained persistently high.Emerging evidence indicates that cell-free DNA(cfDNA),as a novel biomarker and molecular therapeutic target,holds promise for improving the clinical management of sepsis.cfDNA refers to DNA fragments present in body fluids,including naked DNA,membrane-coated DNA,nucleosomes,and neutrophil extracellular traps(NETs).cfDNA is released from host cells or pathogens into body fluids through pathways,such as NETosis,mitochondrial damage,cell necrosis,apoptosis,pyroptosis,and erythroblast enucleation.The released cfDNA triggers a strong inflammatory response by activating Toll-like receptor(TLR)9,the absent in melanoma 2(AIM2)inflammasome,and the cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway.At the same time,cfDNA activates the coagulation cascade and inhibits anticoagulant and fibrinolytic systems through multiple mechanisms,resulting in microcirculatory disorders.These pathological effects are closely associated with sepsis-related organ dysfunction and poor prognosis.Elucidation of the release and pathological mechanisms of cfDNA provides a foundation for the development of targeted treatment strategies.Currently,molecular therapeutic approaches targeting cfDNA,including peptidylarginine deiminase(PAD)4 inhibitors,pore-forming inhibitors,antioxidants,cfDNA scavengers,and deoxyribonucleases(DNases),have shown certain efficacy in treating sepsis and systemic inflammation.In terms of sepsis monitoring,compared with traditional markers,cfDNA exhibits extremely high timeliness and dynamic monitoring capability.cfDNA can simultaneously indicate the complex interplay among infection,host response,and organ damage,making it suitable for early diagnosis,prognosis assessment,treatment monitoring,organ function evaluation,and pathogen detection.Given its broad application prospects in the diagnosis and treatment of sepsis,this paper systematically elaborates on the mechanisms of cfDNA release and pathological effects in sepsis,reviews progress in cfDNA-targeted monitoring and therapeutic strategies,discusses technical challenges,and outlines potential future directions. 展开更多
关键词 Sepsis Cell-free DNA(cfDNA) Liquid biopsy cfDNA scavengers Deoxyribonuclease(DNase)
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Malbrumpenoids A-N,unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16 认领 引用
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作者 Shu-Qi Wu Xinying Zhu +5 位作者 Fang-Yu Yuan Han-Zhuang Weng Lei Li Dong Huang Gui-Hua Tang Sheng Yin 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期427-432,共6页
Molecular networking-guided chemical investigation of the Euphorbia endophyte Malbranchea umbrina D16 led to the isolation of 14 novel unusually cyclized triterpenoids(UCT)involving three different skeletal types.Comp... Molecular networking-guided chemical investigation of the Euphorbia endophyte Malbranchea umbrina D16 led to the isolation of 14 novel unusually cyclized triterpenoids(UCT)involving three different skeletal types.Compounds 1–10 are tricyclic triterpenoids featuring a 1-cyclohexyloctahydro-1H-indene core,in which 1 incoporates an unusual 7,7-dimethyl-6,8-dioxabicyclo[3.1.2]octane motif.Compounds 11–13represent a rare class of bicyclic triterpenes(6/5 ring system)containing various O-heterocycles at the side chain.Compound 14 is an acyclic triterpenoid with O-heterocycles at both ends.Their structures were assigned by spectroscopic,chemical,computational,and crystallographic means,which also allowed the stereochemical revisions of three previously reported analogues.Compound 1 significantly inhibited the adipogenesis in 3T3-L1 adipocytes via activating the AMP-activated protein kinase(AMPK)signalling. 展开更多
关键词 Endophytes Malbranchea umbrina D16 Unusually cyclized triterpenoids Malbrumpenoid Antiadipogenic activity AMP-activated protein kinase
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Penispirolactam and penipyrroloindole,two unusual polycyclic indole diterpenoids with anti-hepatic fibrosis activity from the endophytic fungus Penicillium janthinellum H-6 认领 引用
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作者 Lei Li Xin-Ying Zhu +6 位作者 Jun-Yu Zhu Zhi-Hao Wu Yan-Jiang Zhang Fang-Yu Yuan Dong Huang Sheng Yin Gui-Hua Tang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期567-572,共6页
Penispirolactam(1)and penipyrroloindole(2),two highly modified paspaline-type indole diterpenoids(IDTs),along with three new(3-5)and two known(6 and 7)paspaline-type IDTs were obtained from the endophytic fungus Penic... Penispirolactam(1)and penipyrroloindole(2),two highly modified paspaline-type indole diterpenoids(IDTs),along with three new(3-5)and two known(6 and 7)paspaline-type IDTs were obtained from the endophytic fungus Penicillium janthinellum H-6 guided by liquid chromatography-mass spectrometry(LCMS)-based molecular network.Architecturally,penispirolactam(1)possesses a unique octacyclic skeleton(6/5/6/6/5/6/6/6)with a spiro core formed by the integration of a C6-C2 unit with the indole moiety,and penipyrroloindole(2)represents a rearranged octacyclic skeleton(6/5/6/5/5/6/6/6)with a pyrrolo[1,2-a]indole core fragment.Their structures,including absolute configurations,were established by detailed spectroscopic analysis,gauge-independent atomic orbital(GIAO)1D nuclear magnetic resonance(NMR)(DP4+)calculation protocol,and electronic circular dichroism(ECD)calculation method.The plausible biosynthetic pathway of compounds 1 and 2 was also speculated.Additionally,the anti-hepatic fibrosis activity of all compounds was explored,and it was found that 1 could exert its effects by inhibiting the transforming growth factor-β(TGF-β)/Smad signaling pathway without cytotoxicity. 展开更多
关键词 Endophytic fungus Penicillium janthinellum H-6 Paspaline-derived indole diterpenoid Penispirolactam Penipyrroloindole Anti-hepatic fibrosis
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Spatiotemporal Habitat Use in Juvenile Chinese Alligators(Alligator sinensis):Interactive Effects of Sunlight and Time 认领 引用
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作者 Jianjun MIAO Ke SUN +9 位作者 Shunli YE Yongkang ZHOU Zhenpeng YU Lei LI Pingsi YI Tongsheng XIA Genjun TU Dallin B.KOHLER Xiaobing WU Tao PAN 《Asian Herpetological Research》 SCIE CAS CSCD 2026年第2期157-165,共9页
The fine-scale habitat selection behavior of juvenile Chinese alligators(Alligator sinensis)is crucial to understand for ex situ environment design and in situ habitat restoration,yet how thermal requirements shape th... The fine-scale habitat selection behavior of juvenile Chinese alligators(Alligator sinensis)is crucial to understand for ex situ environment design and in situ habitat restoration,yet how thermal requirements shape their microhabitat use remains unclear.To address this,we studied ten juveniles in a semi-natural artificial pond with four environmentally distinct quadrants during September 2025.Using 24-h video surveillance and systematic sampling,we analyzed their spatial use patterns,diel rhythms,and environmental drivers via temporal trend analysis and generalized linear mixed modeling(GLMM).Results indicated heterogeneous space use across quadrants and spatially distinct diel rhythms.Habitat selection was best explained by an interaction between solar exposure ratio and time of day.The GLMM revealed a significant interaction between solar exposure ratio and time period(P<0.05),with simple slope analysis showing that solar exposure ratio had a strong positive effect on habitat use in the afternoon and night but not the morning.Concealment area also had a consistent positive effect.These findings demonstrate that juvenile Chinese alligators employ a dynamic,thermalrequirement-driven spatiotemporal strategy.This behavioral plasticity is critical for maintaining physiological homeostasis,suggesting that access to thermally heterogeneous habitats may be an important consideration in conservation planning for this species. 展开更多
关键词 Alligator sinensis behavioral thermoregulation habitat selection spatiotemporal patterns generalized linear mixed model conservation management
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Shape-preserving mesh deformation method of perforated surfaces and application to double-wall turbine blade leading edge 认领 引用
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作者 Zhenyuan ZHANG Honglin li +3 位作者 Zhonghao TANG Yajie BAO Yujie ZHAO Lei LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第1期313-332,共20页
A Hybrid Free-Form Deformation(HFFD)method is developed to improve shape preservation in mesh deformation for perforated surfaces,which traditional Free-Form Deformation(FFD)techniques struggle to handle effectively.T... A Hybrid Free-Form Deformation(HFFD)method is developed to improve shape preservation in mesh deformation for perforated surfaces,which traditional Free-Form Deformation(FFD)techniques struggle to handle effectively.The proposed method enables high-fidelity parameterized deformation for both flat and curved perforated surfaces while maintaining mesh quality with minimal geometric distortion.To evaluate its effectiveness,comparative studies between HFFD and conventional FFD methods are conducted,demonstrating superior performance in mesh quality and geometric fidelity.The HFFD-based framework is further applied to the Multidisciplinary Design Optimization(MDO)of a double-wall turbine blade leading edge.Results indicate an 11.6%increase in cooling efficiency and a 16.21%reduction in maximum stress.Additionally,compared to traditional geometry-based parameterization in MDO,the HFFD approach improves model processing efficiency by 84.15%and overall optimization efficiency by20.05%.These findings demonstrate HFFD's potential to significantly improve complex engineering design optimization by achieving precise shape preservation and improving computational efficiency. 展开更多
关键词 Double-wall turbine blade Free-form mesh deformation Multidisciplinary design optimization Parameterized mesh deformation Surrogate model
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Nondestructive detection of key phenotypes for the canopy of the watermelon plug seedlings based on deep learning 认领 引用
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作者 Lei Li Zhilong Bie +4 位作者 Yi Zhang Yuan Huang Chengli Peng Binbin Han Shengyong Xu 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第1期149-160,共12页
Nondestructive measurement technology of phenotype can provide substantial phenotypic data support for applications such as seedling breeding,management,and quality testing.The current method of measuring seedling phe... Nondestructive measurement technology of phenotype can provide substantial phenotypic data support for applications such as seedling breeding,management,and quality testing.The current method of measuring seedling phenotypes mainly relies on manual measurement which is inefficient,subjective and destroys samples.Therefore,the paper proposes a nondestructive measurement method for the canopy phenotype of the watermelon plug seedlings based on deep learning.The Azure Kinect was used to shoot canopy color images,depth images,and RGB-D images of the watermelon plug seedlings.The Mask-RCNN network was used to classify,segment,and count the canopy leaves of the watermelon plug seedlings.To reduce the error of leaf area measurement caused by mutual occlusion of leaves,the leaves were repaired by CycleGAN,and the depth images were restored by image processing.Then,the Delaunay triangulation was adopted to measure the leaf area in the leaf point cloud.The YOLOX target detection network was used to identify the growing point position of each seedling on the plug tray.Then the depth differences between the growing point and the upper surface of the plug tray were calculated to obtain plant height.The experiment results show that the nondestructive measurement algorithm proposed in this paper achieves good measurement performance for the watermelon plug seedlings from the 1 true-leaf to 3 true-leaf stages.The average relative error of measurement is 2.33%for the number of true leaves,4.59%for the number of cotyledons,8.37%for the leaf area,and 3.27%for the plant height.The experiment results demonstrate that the proposed algorithm in this paper provides an effective solution for the nondestructive measurement of the canopy phenotype of the plug seedlings. 展开更多
关键词 Watermelon seedlings Azure Kinect Canopy Phenotype detection Deep learning
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Plant-pathogen interactions and transmissions:Unraveling the complex role of pathogen vectors in disease ecology 认领 引用
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作者 Muhammad Zulqar Nain Dara Arzlan Abbas +3 位作者 Aroge Temitope Lei Li Guohua Duan Wenxian Sun 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第7期2635-2668,共34页
Plant–pathogen interactions are complex,multifaceted processes involving various participants,including insect vectors and parasitic plants,that play a crucial role in the spread of plant diseases.This review explore... Plant–pathogen interactions are complex,multifaceted processes involving various participants,including insect vectors and parasitic plants,that play a crucial role in the spread of plant diseases.This review explores the intricate relationships between plants,pathogens,and insect vectors,emphasizing these interactions'ecological and epidemiological significance.Insect vectors,such as aphids,leafhoppers,whiteflies,and beetles,transmit various plant pathogens,including viruses,bacteria,fungi,and phytoplasmas,through different mechanisms.The transmission mode can be direct or indirect,continuous or discontinuous,depending on the biology of the pathogen and the insect vector.We differentiate between noncirculative and circulative pathogen transmission pathways and describe how pathogen movement within insect bodies influences their ability to spread diseases to new plant hosts.The impacts of these interactions extend beyond agricultural productivity to encompass significant economic losses,environmental challenges,and potential human health risks due to excessive use of chemical controls.Understanding these complex dynamics is essential for designing effective disease management strategies and developing environmentally sustainable control measures.This review synthesizes current knowledge on the transmission mechanisms,types of plant pathogens,and the consequences of insect-mediated disease spread,providing insights crucial for advancing plant protection and integrated pest management practices. 展开更多
关键词 phytopathogen—insect interactions transmission mechanism insect vector borne diseases host vulnerability environmental influences
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Intramolecular Design of Poly(ethylene oxide)for Solid-State Electrolytes and Next-Generation High-Energy Batteries 认领 引用
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作者 Shijun Zhang Ruiliu Jia +9 位作者 Xiaoyu Ji Ziqing Zeng Lei Li Lijun Fu Jianjun Zhang Bin Chen Yen Wei Henghui Xu Yang Yang Guanglei Cui 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第10期845-886,共42页
Solid-state electrolytes(SSEs)are key materials for next-generation high-energy batteries because of their enhanced chemical and mechanical stabilities.Poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs)e... Solid-state electrolytes(SSEs)are key materials for next-generation high-energy batteries because of their enhanced chemical and mechanical stabilities.Poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs)exhibit great physical contact with electrodes,electrochemical compatibility with lithium(Li)metal anodes,as well as easy processibility and high economic efficiency,having become the pioneer and one frontrunner for developing all-solid-state high-energy batteries.However,PEO-based SPEs also suffer from a trade-off between ionic conductivity and mechanical strength,an insufficient cationic transference number,and a weak high-voltage stability,limiting their practical achievement in desirable power and energy density.Herein,we present a comprehensive overview on the intramolecular design strategies of PEO,which has the potential to fundamentally tackle above challenges compared to the intermolecular plasticizer or ceramic blending approaches.Topological and chemical designs for target mechano-electro-chemical performance are classified and summarized in detail.On this basis,a perspective on the unconquered issues and future directions is proposed,providing guidance for the design and application of high-performance SSEs for next-generation high-energy batteries,with special emphasis on the rational integration of intramolecular and intermolecular methods and the development of advanced manufacture techniques for flexible yet robust thin films. 展开更多
关键词 Poly(ethylene oxide)(PEO) Molecular design Solid-state electrolyte High-energy batteries
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Bending solutions of Reddy beams based on modified couple stress theory in terms of Euler-Bernoulli beams 认领 引用
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作者 Shenao ZHAO Lei LI Pengpeng SHI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第5期1085-1104,共20页
The bending behavior of microbeams in micro-nano devices exhibits significant size effects,making accurate prediction of their mechanical behaviors crucial for device reliability.This paper employs the modified couple... The bending behavior of microbeams in micro-nano devices exhibits significant size effects,making accurate prediction of their mechanical behaviors crucial for device reliability.This paper employs the modified couple stress theory(MCST)and derives the governing equations for the Reddy beam theory(RBT)via the principle of virtual work.By considering the load equivalence,the analytical solutions for the bending problem are derived and expressed as the functional relations based on the Euler-Bernoulli beam model.Once the Euler-Bernoulli beam solution is obtained,the exact solution for the corresponding Reddy beam can be directly determined through these functional relations and boundary conditions.Analytical solutions for the doubly simply-supported(S-S),clamped-free(C-F),and clamped-clamped(C-C)boundary conditions are derived and validated through comparison with the results of previous studies.This study clarifies the analytical relationship between the two beam theories at the micro-scale,enabling exact mechanical solutions for higher-order shear deformation beams without solving complex higher-order governing equations. 展开更多
关键词 Reddy beam theory(RBT) Euler-Bernoulli beam theory(EBT) modified couple stress theory(MCST) bending solution
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Prognostic Classification of Hepatocellular Carcinoma Under Incomplete Data Conditions Using a Public Reference Cohort:A Weakly Supervised Multi-Omics Study 认领 引用
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作者 Hanlin Lv Xiao Wang +2 位作者 Kesong Wu Lei Li Lei Wang 《Journal of Clinical and Nursing Research》 2026年第4期213-217,共5页
Background:Prognostic stratification of hepatocellular carcinoma(HCC)remains difficult because the disease is highly heterogeneous and complete matched multi-omics data are not always available in clinical cohorts.Obj... Background:Prognostic stratification of hepatocellular carcinoma(HCC)remains difficult because the disease is highly heterogeneous and complete matched multi-omics data are not always available in clinical cohorts.Objective:To develop a weakly supervised multi-omics framework that derives prognostic subtype labels from a public reference cohort and transfers them to cohorts with incomplete data.Methods:This study has analyzed 363 patients in TCGA-LIHC with matched mRNA,miRNA,DNA methylation,and clinical data.Overall-survival-related features were selected by univariate Cox regression,integrated by similarity network fusion(SNF),and clustered by spectral clustering to generate pseudo-labels.TCGA-LIHC was then split 6:4 into training and test sets for supervised modeling.External validation used LIRI-JP,GSE14520,GSE54236,and GSE31384,with models rebuilt on features shared with each cohort.Prognostic performance was evaluated by Kaplan-Meier analysis,log-rank testing,and the concordance index(C-index).Results:A total of 3,890 mRNA features,150 miRNA features,and 1,889 methylation features were retained.SNF plus spectral clustering identified two subtypes:S1(n=257)and S2(n=106).S2 had significantly worse overall survival than S1(log-rank P=3.891×10-9;C-index=0.866).In internal validation,XGBoost showed the highest AUC(0.983).In external validation,the predicted subtypes remained prognostically informative,with C-index values of 0.857 in LIRI-JP,0.875 in GSE14520,0.930 in GSE54236,and 0.883 in GSE31384.Conclusions:In the public datasets included in this study,this weakly supervised framework identified two prognostically distinct HCC subtypes and retained prognostic discrimination after transfer to external cohorts with incomplete data. 展开更多
关键词 Hepatocellular carcinoma Prognostic classification Machine learning Incomplete data Multi-omics
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Obtaining extremely low coercivity of high Bs FeCoBSiCPCu nanocrystalline alloys through modulation of magnetic anisotropy 认领 引用 被引量：7
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作者 Mingjuan Cai Zhijun Guo +5 位作者 Lei Li Xingyu Zheng Xiaoxuan Yang Qianqian Liu Gaopeng Zou Baolong Shen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第4期105-112,共8页
Longitudinal magnetic field annealing is utilized for modifying the magnetic anisotropy and enhancing the magnetic softness of Fe75Co8(B10Si3C3P1)1-x/17Cux(x=0.5,0.75,1,1.25)nanocrystalline all... Longitudinal magnetic field annealing is utilized for modifying the magnetic anisotropy and enhancing the magnetic softness of Fe75Co8(B10Si3C3P1)1-x/17Cux(x=0.5,0.75,1,1.25)nanocrystalline alloys.All of the magnetic field-annealed nanocrystalline alloys with Cu content more than 0.5 at.%exhibit significantly improved soft-magnetic properties,including high saturation magnetic flux density up to 1.87 T,effective permeability of 13,000-16,000 under the condition of 1 A/m and 1 kHz,coercivity as low as 1.6 A/m,and core loss of 0.11-0.45 W/kg under the condition of 1.0 T and 50 Hz.The application of a magnetic field promotes the nucleation and inhibits the growth of grains,leading to an increase in the number density of nanocrystals and the crystalline volume fraction,and a reduction in the grain size.The magnetic field annealing reduces the effective magneto-crystalline anisotropy energy to 2-4 J/m3,and induces longitudinal magnetic anisotropy with anisotropy energy density of 400-900 J/m3which shows dependence on the crystalline volume fraction.The field-induced magnetic anisotropy dominates over the random local magnetic anisotropies,and results in the formation of regular magnetic domains aligned longitudinally,pinning-free domain wall displacement,and thus enhanced soft-magnetic properties. 展开更多
关键词 Nanocrystalline alloy Magnetic anisotropy Magnetic field annealing Soft-magnetic property Microstructure
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A Low Light Image Enhancement Method Based on Dehazing Physical Model 认领 引用 被引量：5
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作者 Wencheng Wang Baoxin Yin +2 位作者 Lei Li Lun Li Hongtao Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第5期1595-1616,共22页
In low-light environments,captured images often exhibit issues such as insufficient clarity and detail loss,which significantly degrade the accuracy of subsequent target recognition tasks.To tackle these challenges,th... In low-light environments,captured images often exhibit issues such as insufficient clarity and detail loss,which significantly degrade the accuracy of subsequent target recognition tasks.To tackle these challenges,this study presents a novel low-light image enhancement algorithm that leverages virtual hazy image generation through dehazing models based on statistical analysis.The proposed algorithm initiates the enhancement process by transforming the low-light image into a virtual hazy image,followed by image segmentation using a quadtree method.To improve the accuracy and robustness of atmospheric light estimation,the algorithm incorporates a genetic algorithm to optimize the quadtree-based estimation of atmospheric light regions.Additionally,this method employs an adaptive window adjustment mechanism to derive the dark channel prior image,which is subsequently refined using morphological operations and guided filtering.The final enhanced image is reconstructed through the hazy image degradation model.Extensive experimental evaluations across multiple datasets verify the superiority of the designed framework,achieving a peak signal-to-noise ratio(PSNR)of 17.09 and a structural similarity index(SSIM)of 0.74.These results indicate that the proposed algorithm not only effectively enhances image contrast and brightness but also outperforms traditional methods in terms of subjective and objective evaluation metrics. 展开更多
关键词 Dark channel prior quadtree decomposition genetic algorithm atmospheric light image enhancement
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Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis 认领 引用 被引量：3
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作者 Lei Li Chen Zhao +13 位作者 Ruizhi Zhang Wen Wei Bowen Liu Jin Dong Xueqin Gao Di Zhang Xueqing Wang Meilin Lu Yumu Zhang Yao Yu Na Yuan Youjia Xu Jianrong Wang Yixuan Fang 《Bone Research》 SCIE CAS CSCD 2025年第3期655-670,共16页
The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains largely elusive.Using conditional gene knockout mouse models,we demonstrated that loss of Beclin 1(B... The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains largely elusive.Using conditional gene knockout mouse models,we demonstrated that loss of Beclin 1(Becn1),a major regulator of mammalian autophagy,exclusively in the megakaryocytic lineage disrupted autophagy in platelets but did not compromise megakaryopoiesis or the formation and function of platelets.Unexpectedly,conditional Becn1 deletion in male mice led to a remarkable increase in bone mass with improved bone quality,in association with a decrease in sex hormone binding globulin(SHBG)and an increase in free testosterone(FT).In vivo Becn1 overexpression in megakaryocytic lineage-specific cells reduced bone mass and quality,along with an increase in SHBG and a decrease in FT.Transplantation of wild-type bone marrow cells into megakaryocytic lineage Becn1-deficient male mice restored bone mass and normalized SHBG and FT.Furthermore,bilateral orchiectomy of Becn1f/f;Pf4-iCre mice,which are crippled with the production of testosterone,resulted in a reduction in bone mass and quality,whereas in vivo overexpression of SHBG,specifically in the liver of Becn1f/f;Pf4-iCre mice,decreased FT and reduced bone mass and quality.In addition,metformin treatment,which induces SHBG expression,reduced FT and normalized bone mass in Becn1f/f;Pf4-iCre mice.We thus concluded that Becn1 of the megakaryocytic lineage is dispensable locally for platelet hemostasis but limits bone mass by increasing SHBG,which in turn reduces the FT of male mice.Our findings highlight a mechanism by which Becn1 from megakaryocytic lineage cells distally balances bone growth. 展开更多
关键词 megakaryocytic lineage cells Beclin autophagy Megakaryocytic lineage megakaryocytic lineage Bone homeostasis bone ma conditional gene knockout mouse modelswe
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Phase transition controlled construction of Z-scheme heterojunction Ce3+/Ce4+doped metastableβ-Bi2O3/AgI for efficient carrier separation in visible-light-driven photocatalysis 认领 引用 被引量：3
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作者 Zhouzheng Jin Lei Li +7 位作者 Chunshuai Cao Huiling Dong Ao Li Xueping Peng Aijing Ma Shiguang Pan Dan Liu Jianzhou Gui 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第5期940-952,共13页
Ce-β-Bi2O3/AgI was prepared using solvothermal calcination and in-situ deposition methods.The introduction of Ce can inhibit the conversion of Bi2O3fromβtoαphase at high temperatures,promoting the forma... Ce-β-Bi2O3/AgI was prepared using solvothermal calcination and in-situ deposition methods.The introduction of Ce can inhibit the conversion of Bi2O3fromβtoαphase at high temperatures,promoting the formation of oxygen vacancies(OVs)in the photocatalyst.OVs can adsorb more dissolved oxygen to promote the formation rate of·O-2.Moreover,the interaction between Ce-Bi2O3and AgI results in the formation of Z-scheme heterojunctions,which can broaden the light absorption region,facilitate photogenerated carrier separation and transfer and enhance the ability to produce more active oxygen species(ROS).The morphology,crystal,element distribution and photo-electric chemical properties of the Ce-Bi2O3/AgI were analyzed,and the result shows that the optimal ratio of Ce-Bi2O3/AgI photocatalyst achieves a removal rate of 88.63%(180 min)of tetracycline(TC)(20 mg/L)and 100%(120 min)of methyl orange(MO)(20 mg/L).This work clarified the photocatalytic degradation mechanism,providing a promising avenue for developing photocatalytic composites by rare earth metal doping in environme ntal remediation applications. 展开更多
关键词 Ce-Bi2O3/AgI Z-scheme heterojunction Oxygen vacancies Photocatalysis Tetracycline degradation Rare earths
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Synergistic anti-corrosion and anti-wear of epoxy coating functionalized with inhibitor-loaded graphene oxide nanoribbons 认领 引用 被引量：2
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作者 Jianxi Liu Yifan Fang +6 位作者 Yang Ou Xiaowei Shi Yaoming Zhang Qiang Chen Lei Li Feng Zhou Weimin Liu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第17期140-149,共10页
The synergy between corrosion protection and wear resistance is an effective strategy for the development of multifunctional coating to withstand complex working conditions.This study reports an epoxy resin coating fi... The synergy between corrosion protection and wear resistance is an effective strategy for the development of multifunctional coating to withstand complex working conditions.This study reports an epoxy resin coating filled with benzotriazole loaded metal-organic frameworks(BTA-MOFs)functionalized graphene oxide nanoribbons(GONR)that exhibit active anti-corrosion,act as a barrier to corrosive ion,and enhance wear resistance.The GONR@BTA-MOFs composite is synthesized through chemically etching multi-walled carbon nanotubes and subsequent electrostatic self-assembly corrosion inhibitors loaded MOFs onto the GONR.The composite demonstrates improved compatibility with epoxy resins compared to carbon nanotubes.The anti-corrosion performance of the composite coating is investigated using electrochemical impedance spectroscopy.After immersing in a 3.5 wt.%NaCl solution for 25 d,the alternating current impedance of the composite coating is three orders of magnitude higher than that of pure epoxy resin.Simultaneously,the controlled release of the corrosion inhibitor retards the deterioration of the coating after localized damage occurrence,which functions as active corrosion protection.The GONR@BTA-MOFs/EP composite coating exhibits the highest corrosion potential of-0.188 V and the lowest corrosion current of 3.162×10−9A cm−2in the Tafel test.Tribological studies reveal a reduction in the friction coefficient from 0.62 to 0.08 after incorporating GONR@BTA-MOFs in the coating,with the wear volume being seven times lower than that of pure epoxy resin.The excellent lubrication effect of the nanomaterials reduces the coefficient of friction of the coating,thereby improving the abrasion resistance of the coating.The synergy between the self-lubrication of the two-dimensional layered fillers and the corrosion resistance of the smart inhibitor containers suggests a promising strategy for enhancing the performance of epoxy resins under complex working conditions. 展开更多
关键词 Graphene nanoribbons MOFs Corrosion protection Anti-wear Epoxy
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High-throughput phenotyping discovers new stable loci controlling senescence rate in bread wheat 认领 引用 被引量：1
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作者 Lei Li Jindong Liu +10 位作者 Muhammad Adeel Hassan Duoxia Wang Keyi Wang Shuaipeng Fei Jianqi Zeng Awais Rasheed Xianchun Xia Zhonghu He Yong He Yong Zhang Yonggui Xiao 《The Crop Journal》 SCIE CAS CSCD 2025年第4期1168-1177,共10页
Non-destructive time-series assessment of chlorophyll content in flag-leaf(FLC)accurately mimics the senescence rate and the identification of genetic loci associated with senescence provides valuable knowledge to imp... Non-destructive time-series assessment of chlorophyll content in flag-leaf(FLC)accurately mimics the senescence rate and the identification of genetic loci associated with senescence provides valuable knowledge to improve yield stability under stressed environments.In this study,we employed both unmanned aerial vehicles(UAVs)equipped with red–green–blue(RGB)camera and ground-based SPAD-502 instrument to conduct temporal phenotyping of senescence.A total of 262 recombinant inbred lines derived from the cross of Zhongmai 578/Jimai 22 were evaluated for senescence-related traits across three environments,spanning from heading to 35 d post-anthesis.The manual senescence rate(MSR)was quantified using the FLC and the active accumulated temperature,and UAV derived vegetation index were utilized to assess the stay-green rate(USG)facilitating the identification of senescent and stay-green lines.Results indicated that higher senescence rates significantly impacted grain yield,primarily by influencing thousand-kernel weight,and plant height.Quantitative trait loci(QTL)mapping for FLC,USG,and MSR using the 50K SNP array identified 38 stable loci associated with RGB-based vegetation indices and senescence-related traits:among which 19 loci related to senescence traits from UAV and FLC were consistently detected across at least two growth stages,with nine loci likely representing novel QTL.This study highlights the potential of UAV-based high-throughput phenotyping and phenology in identifying critical loci associated with senescence rates in wheat,validating the relationship between senescence rates and yield-related traits in wheat,offering valuable opportunities for gene discovery and significant applications in breeding programs. 展开更多
关键词 Aerial digital imaging Active accumulated temperature Chlorophyll QTL Senescence rate Common wheat
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