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Antidepressant effects and mechanisms of Wuhua herbal tea in a rat model of chronic unpredictable mild stress 认领 引用
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作者 Zhiwei Qi Lingling Qin +7 位作者 Ming Gao Ruifeng Yang Congyi Liu Ning Wang Wenjing Li Yongxin Huang Lili Wu Tonghua Liu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第3期364-374,共11页
Objective:To evaluate the effects of Wuhua herbal tea on chronic unpredictable mild stress(CUMS)-induced depression and explore its mechanism of action in combating depression.Methods:We tested the antidepressant effe... Objective:To evaluate the effects of Wuhua herbal tea on chronic unpredictable mild stress(CUMS)-induced depression and explore its mechanism of action in combating depression.Methods:We tested the antidepressant effects of Wuhua herbal tea in a rat model of CUMS-induced depression using fluoxetine as a positive control.The rats were divided into four groups:control group,model group,fluoxetine group,and Wuhua herbal tea group.The rats underwent body weight measurements,sucrose preference test,and open-field test.Enzyme-linked immunosorbent assay kits were used to detect the serum levels of serotonin,dopamine,adrenocorticotropic hormone(ACTH),corticosterone,norepinephrine,and interleukin-6.Intergroup comparisons and detection of brain-derived neurotrophic factor(BDNF),cAMP-response element binding protein(CREB),Janus kinase 2(JAK2),and signal transducer and activator of transcription 3(STAT3)mRNA expression in the hippocampus were performed using RTPCR.Immunohistochemistry was used to identify the expression of phosphorylated JAK2(p-JAK2)and phosphorylated STAT3(p-STAT3)proteins in hippocampal paraffin sections of CUMS rats.Results:Compared with the control group,the model group rats had depressive tendencies,exhibiting low vitality and interest in various behavioral indicators which were signs of despair.The Wuhua herbal tea group statistically increased the levels of serotonin and dopamine in the serum of CUMS rats to varying degrees(P=.015 and P=.002);reduced serum levels of ACTH,corticosterone,norepinephrine,and interleukin-6(all P<.05);and decreased mRNA expression of BDNF,CREB,JAK2,and STAT3 in the hippocampus(all P<.05);and decreased p-STAT3 protein levels(P=.006).Conclusion:Wuhua herbal tea shows antidepressant potential in CUMS rats by modulating the HPA axis and inhibiting JAK2-STAT3 overactivation,alleviating neuroinflammation.It also restores BDNF-CREB pathway function,reducing depressive symptoms. 展开更多
关键词 Depression Wuhua herbal tea Neuroinflammation Chronic unpredictable mild stress Medicine and food homology
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Adaptive leadership in advancing professionalism among clinical nurse educators:A mixed-methods study 认领 引用
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作者 Xiyi Wang Nianqi Cui +6 位作者 Fule Wen Lili Wu Yunhua Jia Xiaoyin Niu Shu Xu Geraldine Lee Yun Hu 《International Journal of Nursing Sciences》 CSCD 2026年第4期396-405,共10页
Objectives:To investigate the professionalism among clinical nurse educators and examine how adaptive leadership supports their transition from clinical practice to educational roles.Methods:A sequential explanatory m... Objectives:To investigate the professionalism among clinical nurse educators and examine how adaptive leadership supports their transition from clinical practice to educational roles.Methods:A sequential explanatory mixed-methods design,informed by Wheel of Professionalism in Nursing theory and Adaptive Leadership Theory,was conducted between December 2021 and January 2022.Participants comprised registered nurses from teaching hospitals across five provinces and municipalities in China(Shanghai,Zhejiang,Chongqing,Hebei,and Shanxi).Quantitative data were collected through a multi-center cross-sectional survey involving 669 respondents using the Behavioral Inventory for Professionalism in Nursing.Qualitative data were obtained via focus group interviews with 12 purposively selected participants.Data integration was conducted through content analysis,structured around key dimensions of professionalism.Results:The professionalism score was significantly lower among clinical nurse educators than among their managers[11.00(8.50,14.00)vs.15.00(9.25,19.50),Z=-4.110,P0.05),whereas significant differences were found across the remaining six dimensions(P<0.05).Qualitative findings yielded three themes:1)adaptive alignment with institutional priorities;2)driving change within complexity;and 3)contributing to social and professional impact.These findings illustrate how adaptive leadership processes shape the development and enactment of professionalism,particularly in navigating role transition and organizational expectations.Conclusions:Clinical nurse educators demonstrate comparatively lower levels of professionalism than their managers’expectations,with gaps concentrated in multiple practice domains.Adaptive leadership plays a pivotal role in bridging these gaps by enabling clinical nurse educators to respond to complex role demands and evolving institutional contexts.Targeted strategies,including structured training,organizational support,and policy-level interventions,are essential to strengthen professionalism and support sustainable workforce development. 展开更多
关键词 Adaptive leadership Clinical nurse educator Cross-sectional study Mixed-methods design Professionalism Qualitative research
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Therapeutic effects and mechanism of Panax notoginseng(Burk)F.H.Chen flowers on glycolipid metabolism in type 2 diabetes mellitus based on network pharmacology and transcriptomics 认领 引用
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作者 Wei Liu Peng Tian +5 位作者 Wenjing Li Yahui Sun Yifei Zhu Lingling Qin Lili Wu Tonghua Liu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2026年第1期101-116,共16页
Objective:To investigate the effects and potential mechanisms of action of Panax notoginseng(Burk)F.H.Chen(P.notoginseng,San Qi)flowers in type 2 diabetes mellitus(T2DM)using network pharmacology,in vivo experiments,a... Objective:To investigate the effects and potential mechanisms of action of Panax notoginseng(Burk)F.H.Chen(P.notoginseng,San Qi)flowers in type 2 diabetes mellitus(T2DM)using network pharmacology,in vivo experiments,and RNA sequencing(RNA-seq).Methods:Network pharmacology analysis was performed to identify and correlate the drug targets of flower buds of P.notoginseng(PNF)with T2DM disease targets and to predict the key targets and pathways involved in the therapeutic effects of PNF in T2DM.In vivo experiments were conducted to assess the effects of PNF on glucose and lipid metabolism in mice with T2DM.RNA-seq was performed,and the results were integrated with network pharmacology data to assess the therapeutic mechanisms of PNF in T2DM.The results from transcriptomics and network pharmacology were validated using real-time polymerase chain reaction.Results:A total of 27 intersecting targets were identified by overlapping 35 drug targets with T2DM targets.Further topological analysis using the Centiscape 2.2 tool revealed five core targets,including signal transducer and activator of transcription 3(STAT3).Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis indicated that the JAK/STAT signaling pathway is a key mechanism underlying the therapeutic effects of PNF in T2DM.In vivo experiments confirmed that PNF effectively regulates glycolipid metabolism in a mouse model of diabetes.KEGG pathway enrichment analysis of RNA-seq data highlighted the JAK2/STAT3 and PI3K/AKT pathway as a potential mechanism.PNF high-dose(PNFH)increased the gene expression levels of PIK3R1 and AKT2,decreased the expression of PCK1,JAK2,and STAT3,and showed a trend toward increasing INSR expression without reaching statistical significance.Conclusion:PNF improves glycolipid metabolism disorders in T2DM,potentially by modulating the JAK2/STAT3 and PI3K/AKT signaling pathway. 展开更多
关键词 Type 2 diabetes mellitus JAK/STAT RNA sequencing Panax notoginseng(Burk)F.H.Chen flowers Network pharmacology
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Entropy-Driven 1D Magnetic Carbon Fibers Embedded into 3D Aerogel Enable Broadband Electromagnetic Wave Absorption 认领 引用
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作者 Tingting Zhao Shiping Shao +5 位作者 Ke Bi Yunxiang Tang Lili Wu Jiurong Liu Zhou Wang Fenglong Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第10期624-639,共16页
Traditional powder-type electromagnetic absorbers have become inadequate against the intensified radiation across broader frequency ranges,induced by the proliferation of intelligent communication devices.To address t... Traditional powder-type electromagnetic absorbers have become inadequate against the intensified radiation across broader frequency ranges,induced by the proliferation of intelligent communication devices.To address this,we present an innovation strategy to assemble spinel ferrites/carbon fibers into a carbon aerogel fabricated via carbonization of a graphene oxide(GO)/2,2,6,6-tetramethylpiperidine-1-oxyl(TEMPO)-oxidized cellulose nanofibers(TOCNF)composite aerogel.In the preparation,an entropy-driven design integrated with electrospinning was employed to synthesize the magnetic carbon fibers(MCFs),fully leveraging the complementary advantages of magnetic and carbon materials for optimal impedance matching and attenuation.As a result,the optimized magnetic carbon aerogel(MCA-2),composed of TOCNF,GO,and MCFs,exhibits exceptional broadband electromagnetic wave absorption,with multiple effective reflection loss(RL)peaks(RL≤−10 dB)across the frequency range of 4.8-18 GHz,a minimum RL value of−54.11 dB,and a maximum effective absorption bandwidth of 7.2 GHz.Additionally,the lightweight MCA-2 aerogel has excellent thermal insulation performance and excellent photothermal performance,which gives it broad application prospects in diverse and harsh environments. 展开更多
关键词 Electromagnetic wave absorption Electrospinning Carbon fibers Carbon aerogel Spinel ferrites
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Facile manufacturing of carbon nanotub e/ZIF-67-derive d cobalt composite aerogel with high-efficiency electromagnetic wave absorption 认领 引用 被引量：4
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作者 Chang Liu Na Wu +4 位作者 Bin Li Zhou Wang Lili Wu Zhihui Zeng Jiurong Liu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第17期129-139,共11页
Developing high-efficiency electromagnetic wave(EMW)absorbers by designing dielectric/magnetic components and microstructure in a straightforward,scalable method is highly desirable yet challenging.Here,we introduce a... Developing high-efficiency electromagnetic wave(EMW)absorbers by designing dielectric/magnetic components and microstructure in a straightforward,scalable method is highly desirable yet challenging.Here,we introduce a novel hierarchical composite aerogel-based EMW absorber composed of conductive carbon nanotubes(CNTs)and magnetic metal-organic framework(MOF)derivatives,integrated with sustainable cellulose nanofibers(CNF)derived carbon.This composite was prepared using a scalable freeze-casting followed by carbonization approach.Freeze casting enabled the creation of porous monoliths with high specific surface areas and customizable pore sizes and porosities,crucial for enhancing EMW reflection and scattering.Carbonization enhanced composite conductivity and stabilized the cobalt(Co)/carbon nanoparticles derived from ZIF-67 within the carbon matrix.CNF-derived carbon facilitated the efficient integration of ZIF-derived Co nanoparticles and CNTs,resulting in a robust 3D aerogel structure.The synergistic effects of CNT conductive paths and Co nanoparticles’magnetic losses provided an efficient route to enhance EMW absorption.Moreover,the creation of numerous heterogeneous interfaces augmented polarization losses,significantly enhancing EMW loss capability.Remarkably,the composite achieved outstanding EMW absorption,with a minimum reflection loss of-71.03 dB at a filling ratio of merely 10 wt.%and an effective absorption bandwidth of 4.64 GHz,comparable to leading EMW absorbers reported to date. 展开更多
关键词 Aerogel Carbon nanotubes Impedance matching ZIF-67 Electromagnetic wave absorption
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Strengthened dipole-dipole interaction on high-entropy oxide electrocatalysts for high-rate and excellently stable lithium-sulfur batteries 认领 引用
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作者 Xinyue Wang Lirong Zhang +6 位作者 Chi Zhang Xinzhi Ma Qi Jin Lu Li Zhiguo Zhang Xitian Zhang Lili Wu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第6期292-301,I0007,共10页
Electrocatalysts are an effective strategy to mitigate the shuttling effect of lithium polysulfides(LiPSs)and accelerate the redox kinetics of LiPSs in lithium-sulfur(Li-S)batteries.However,traditional electrocatalyst... Electrocatalysts are an effective strategy to mitigate the shuttling effect of lithium polysulfides(LiPSs)and accelerate the redox kinetics of LiPSs in lithium-sulfur(Li-S)batteries.However,traditional electrocatalysts only have a single active site and often undergo structural collapse and aggregation during charging and discharging,resulting in reduced catalytic performance.Herein,the two-dimensional(2D)polar high-entropy La0.71Sr0.29Co0.21Ni0.20Fe0.19Cr0.20Cu0.20O3(LCO-HEO)nanosheets were rationally designed and successfully synthesized to address this issue.The distinct functional polar sites in LCOHEOs were formed by the d-d orbital hybridization between spatially coupling adjacent transition metals,which can strengthen the dipole-dipole interaction between polar LCO-HEOs and polar LiPSs.2D polar LCO-HEO nanosheets can efficiently capture and trigger the tandem catalysis of polar LiPSs during their sequential conversion.The S/LCO-HEO composite cathode exhibits a high specific capacity of 1161.1 mA h g-1at 1.0 C,with an ultralow capacity attenuation rate of 0.036%per cycle over 1200 cycles,and achieves stable cycling for 1500 cycles even at 8.0 C.Furthermore,even with a high sulfur loading(5.5 mg cm-2)and a low electrolyte/sulfur(E/S)ratio(4.0μL mg-1),the S/LCO-HEO composite cathode shows desirable sulfur utilization and good cycle stability.This work demonstrates the feasibility of high entropy-driven multiple distinct functional polar sites for high-rate and long-cycle Li-S batteries. 展开更多
关键词 Lithium-sulfur batteries High-entropy oxide Dipole-dipole interaction Composite cathode D-d orbital hybridization Electrocatalyst
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Chip-like high-entropy oxide catalysts enhance fast sulfur evolution reaction for long-life lithium-sulfur batteries 认领 引用
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作者 Chi Zhang Zhilong Wang +6 位作者 Xinyue Wang Yufei Zhang Zhiguo Zhang An Chen Jinjin Li Xitian Zhang Lili Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第12期397-403,共7页
Many catalysts have shown excellent activity for the sulfur reduction reaction(SRR),but sluggish electrochemistry kinetics have hindered the development of lithium-sulfur batteries.It has been found that the activity ... Many catalysts have shown excellent activity for the sulfur reduction reaction(SRR),but sluggish electrochemistry kinetics have hindered the development of lithium-sulfur batteries.It has been found that the activity of catalysts for the sulfur evolution reaction(SER)plays a crucial role in determining the overall reaction kinetics.To address this issue,the rational design of catalysts is crucial.Here,we proposed a popular rule to accelerate SER by using chip-like high-entropy perovskite oxide La0.7Sr0.3(Fe0.2Co0.2Ni0.2Zn0.2Mn0.2)O3-δ(LMO-HEO)as advanced electrocatalysts.The strong interaction between the adjacent metal atoms in different metals of LMO-HEO electrocatalysts could lead to a"cocktail effect",which not only greatly improved the catalytic capacity toward sulfur species,but also accelerated the oxidation reaction kinetics of Li_2S.As a result,the S/La0.7Sr0.3(Fe0.2Co0.2Ni0.2Zn0.2)Mn0.2O3-δcathodes delivered excellent cyclic stability with a capacity decay of only 0.025%after 1200 cycles at 2 C.This work has provided a rational design idea for new multifunctional electrocatalysts with high catalytic capacity. 展开更多
关键词 Lithium–sulfur battery High–entropy oxide Sulfur evolution reaction Cathode Electrocatalyst
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Exploring the therapeutic potential of propolis in managing diabetes:A preclinical study 认领 引用
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作者 Hannah Shi Tiang Lingling Qin +6 位作者 Tonghua Liu Xiaotong Yang Zhiwei Qi Huizhao Qin Huelee Yong Xuesheng Ma Lili Wu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第2期165-174,共10页
Objective:To evaluate the therapeutic potential and underlying mechanisms of action of propolis in db/db mice.Methods:The chemical composition of propolis was analyzed using UHPLC-MS/MS.Thirty mice,including six wt/wt... Objective:To evaluate the therapeutic potential and underlying mechanisms of action of propolis in db/db mice.Methods:The chemical composition of propolis was analyzed using UHPLC-MS/MS.Thirty mice,including six wt/wt and 24 db/db mice,were randomly assigned to four groups(n=6 per group):control,model,metformin(250 mg/kg),low dose propolis(100 mg/kg),and high dose propolis(HDP;400 mg/kg).Treatments were administered orally for four weeks.Body weight and FBG levels were recorded weekly,and an oral glucose tolerance test was conducted on the 25th day.Serum levels of FIN,GSP,connecting peptide,AST,ALT,HDL,LDL,TG,and TC were quantified using ELISA.Liver histopathology was assessed using H&E and PAS staining.Western blotting was performed to examine the expression levels of NF-κB,phosphorylated NF-κB,IκBa,pIκBa,and AKT in liver tissues.Results:The top 10 metabolites of propolis were identified in positive and negative ion modes.The HDP group exhibited a significant reduction in FBG levels,body weight,connecting peptide levels,homeo-static model assessment of b-cell function scores,and homeostasis model assessment of insulin resis-tance scores(all P<0.05).GSP levels were significantly reduced in both treatment groups(all P<0.001).The HDP group also exhibited a reduction in TC and LDL levels(both P<0.05),whereas HDL levels increased in both treatment groups(all P<0.05).Liver weight,AST levels,and ALT levels were reduced in both treatment groups(all P<0.05).Histological analysis revealed improved liver morphology.Protein analysis demonstrated downregulation of phosphorylated NF-κB and phosphorylated IkB,alongside upregulation of AKT.Conclusion:Propolis exhibited significant antihyperglycemic effects in db/db mice,potentially by modulating the AKT and NF-κB signaling pathways,highlighting its potential as a therapeutic agent for diabetes management. 展开更多
关键词 Propolis Diabetes mellitus db/db mice Protein kinase B Nuclear factor kappa-B
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高校数字化成熟度评估模型的构建和应用 认领 引用 被引量：3
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作者 巫莉莉 张波 李玉峰 《中国教育信息化》 2025年第4期68-77,共10页
高校数字化成熟度评估是监测高校数字化发展水平的重要手段和途径,对评估高校数字化发展现状、对标发展目标找差距、推进数字化转型具有非常重要的现实意义。评估模型的研究以促进教育高质量发展为目标,结合高等教育数字化发展的特点和... 高校数字化成熟度评估是监测高校数字化发展水平的重要手段和途径,对评估高校数字化发展现状、对标发展目标找差距、推进数字化转型具有非常重要的现实意义。评估模型的研究以促进教育高质量发展为目标,结合高等教育数字化发展的特点和内涵,从数字化战略、组织运营、数字基础设施、数字化能力、数字文化等5个维度,构建3层架构的高校数字化成熟度评估体系;结合数字化发展历程,将高校数字化成熟度划分为初始级、规范级、管理级、治理级、生态级,构建高校数字化成熟度评估模型。在此基础上,开发与评估模型相适应的信息系统,以支撑该模型的应用实践,并以某大学为例阐述该模型的具体应用过程。评估模型为高校提供数字化成熟度评估的方法和工具,对高校数字化发展甚至教育数字化转型具有科学的指导意义和辅助决策的作用。 展开更多
关键词 高校数字化 数字化成熟度 数字化转型 指标体系 评估模型
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Research on Bed Call System Based on AT89C52 认领 引用
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作者 Hong Wang Lili Wu 《Journal of Electronic Research and Application》 2025年第1期254-262,共9页
How to realize intelligent and fast bed calls has been a key concern of hospitals.The traditional wired bed call system is not only costly but also less efficient.In this paper,research on bed call systems based on AT... How to realize intelligent and fast bed calls has been a key concern of hospitals.The traditional wired bed call system is not only costly but also less efficient.In this paper,research on bed call systems based on AT89C52 microcontroller is carried out.The nurse-side host(AT89C52)and the bedside slave(AT89C52)communicate over long distances using wireless communication technology.The system transmits signals,including Liquid Crystal Display(LCD),voice announcements,and beeping alarms,to indicate the bed number requiring assistance.This allows the nurse to respond promptly.The system supports real-time updates,where calls and processing occur independently,ensuring efficiency.It is not only cost-effective but also enables a rapid and intelligent call-and-response process. 展开更多
关键词 Bed call system AT89C52 Wireless communication technology Real-time update Call and processing
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Carbon-Based MOF Derivatives:Emerging Efficient Electromagnetic Wave Absorption Agents 认领 引用 被引量：48
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作者 Xue Zhang Jing Qiao +6 位作者 Yanyan Jiang Fenglong Wang Xuelei Tian Zhou Wang Lili Wu Wei Liu Jiurong Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第9期105-135,共31页
To tackle the aggravating electromagnetic wave(EMW)pollution issues,high-efficiency EMW absorption materials are urgently explored.Metal-organic framework(MOF)derivatives have been intensively investigated for EMW abs... To tackle the aggravating electromagnetic wave(EMW)pollution issues,high-efficiency EMW absorption materials are urgently explored.Metal-organic framework(MOF)derivatives have been intensively investigated for EMW absorption due to the distinctive components and structures,which is expected to satisfy diverse application requirements.The extensive developments on MOF derivatives demonstrate its significantly important role in this research area.Particularly,MOF derivatives deliver huge performance superiorities in light weight,broad bandwidth,and robust loss capacity,which are attributed to the outstanding impedance matching,multiple attenuation mechanisms,and destructive interference effect.Herein,we summarized the relevant theories and evaluation methods,and categorized the state-of-the-art research progresses on MOF derivatives in EMW absorption field.In spite of lots of challenges to face,MOF derivatives have illuminated infinite potentials for further development as EMW absorption materials. 展开更多
关键词 Carbon-based MOF derivatives Special structures Multiple attenuation mechanisms Impedance matching EMW absorption
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Non‑Magnetic Bimetallic MOF‑Derived Porous Carbon‑Wrapped TiO2/ ZrTiO4 Composites for Efficient Electromagnetic Wave Absorption 认领 引用 被引量：28
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作者 Jing Qiao Xue Zhang +7 位作者 Chang Liu Longfei Lyu Yunfei Yang Zhou Wang Lili Wu Wei Liu Fenglong Wang Jiurong Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第5期45-60,共16页
Modern communication technologies put forward higher requirements for electromagnetic wave(EMW)absorption materials.Metal-organic framework(MOF)derivatives have been widely concerned with its diverse advantages.To bre... Modern communication technologies put forward higher requirements for electromagnetic wave(EMW)absorption materials.Metal-organic framework(MOF)derivatives have been widely concerned with its diverse advantages.To break the mindset of magneticderivative design,and make up the shortage of monometallic non-magnetic derivatives,we first try non-magnetic bimetallic MOFs derivatives to achieve efficient EMW absorption.The porous carbon-wrapped TiO2/ZrTiO4 composites derived from PCN-415(TiZr-MOFs)are qualified with a minimum reflection loss of−67.8 dB(2.16 mm,13.0 GHz),and a maximum effective absorption bandwidth of 5.9 GHz(2.70 mm).Through in-depth discussions,the synergy of enhanced interfacial polarization and other attenuation mechanisms in the composites is revealed.Therefore,this work confirms the huge potentials of nonmagnetic bimetallic MOFs derivatives in EMW absorption applications. 展开更多
关键词 Bimetallic metal-organic framework PCN-415 MOF derivatives TiO2/ZrTiO4/C composites Electromagnetic wave absorption
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Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials 认领 引用 被引量：32
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作者 Shuyan Hao Hecheng Han +10 位作者 Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第11期107-142,共36页
The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fie... The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. 展开更多
关键词 MXenes Antibacterial mechanisms Photothermal properties Antibacterial applications
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Nitrogen‑Doped Magnetic‑Dielectric‑Carbon Aerogel for High‑Efficiency Electromagnetic Wave Absorption 认领 引用 被引量：17
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作者 Shijie Wang Xue Zhang +5 位作者 Shuyan Hao Jing Qiao Zhou Wang Lili Wu Jiurong Liu Fenglong Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期313-327,共15页
Carbonbased aerogels derived from biomass chitosan are encountering a flourishing moment in electromagnetic protection on account of lightweight,controllable fabrication and versatility.Nevertheless,developing a facil... Carbonbased aerogels derived from biomass chitosan are encountering a flourishing moment in electromagnetic protection on account of lightweight,controllable fabrication and versatility.Nevertheless,developing a facile construction method of component design with carbon-based aerogels for high-efficiency electromagnetic wave absorption(EWA)materials with a broad effective absorption bandwidth(EAB)and strong absorption yet hits some snags.Herein,the nitrogen-doped magnetic-dielectric-carbon aerogel was obtained via ice template method followed by carbonization treatment,homogeneous and abundant nickel(Ni)and manganese oxide(MnO)particles in situ grew on the carbon aerogels.Thanks to the optimization of impedance matching of dielectric/magnetic components to carbon aerogels,the nitrogen-doped magnetic-dielectric-carbon aerogel(Ni/MnO-CA)suggests a praiseworthy EWA performance,with an ultra-wide EAB of 7.36 GHz and a minimum reflection loss(RLmin)of−64.09 dB,while achieving a specific reflection loss of−253.32 dB mm−1.Furthermore,the aerogel reveals excellent radar stealth,infrared stealth,and thermal management capabilities.Hence,the high-performance,easy fabricated and multifunctional nickel/manganese oxide/carbon aerogels have broad application aspects for electromagnetic protection,electronic devices and aerospace. 展开更多
关键词 Electromagnetic wave absorption Wide bandwidth Dielectric-magnetic synergy Multifunction
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Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage 认领 引用 被引量：8
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作者 Lili Wu Chuanlian Ran +5 位作者 Shukao Liu Lizhen Liao Yanling Chen Hualei Guo Weikang Wu Can Yan 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第12期1091-1102,共12页
The traditional Chinese medicine Jiaweisinisan has antidepressant effects,and can inhibit hypothalamus-pituitary-adrenal gland axis hyperactivity in stress-induced depression.In this study,rat hippocampal neural precu... The traditional Chinese medicine Jiaweisinisan has antidepressant effects,and can inhibit hypothalamus-pituitary-adrenal gland axis hyperactivity in stress-induced depression.In this study,rat hippocampal neural precursor cells were cultured in serum-free medium in vitro and a stress damage model was established with 120 IJM corticosterone.Cells were treated with 10%(v/v)Jiaweisinisan drug-containing serum and the corticosterone antagonist RU38486.Results of the 3-(4,5-dimethylthiazol-2-yl)-3,5-di-phenytetrazoliumromide assay showed that both Jiaweisinisan drug-containing serum and RU38486 promoted the proliferation of neural precursor cells after corticosterone exposure.Immunofluorescence detection showed that after Jiaweisinisan drug-containing serum and RU38486 treatment,the 5-bromo-2-deoxyuridineerminal deoxynucleotidyl transferase dUTP nick end labeling ratio in hippocampal neural precursor cells significantly increased,and the apoptotic rates of glial cells reduced,and neuron-like cell differentiation from neural precursor cells significantly increased.Our experimental findings indicate that Jiaweisinisan promotes hippocampal neurogenesis after stress damage. 展开更多
关键词 neural regeneration traditional Chinese medicine Jiaweisinisan corticosterone hippocampalneural precursor cells proliferation differentiation apoptosis grants-supported paper neuroregeneration
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Effects of GBE50 on hippocampal CA1 synaptic plasticity,learning and memory in an experimental rat model of aging 认领 引用 被引量：9
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作者 Lili Wu Xianwen Dong +4 位作者 Gaiying He Zhixiong Zhang Ying Xu Xingyu Wang Yun Li 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第12期892-897,共6页
The content of total flavonoids in an extract of Ginkgo biloba,called GBE50,is 44%by weight.This is significantly greater than that in a standard extract of Ginkgo biloba,designated EGB761.To date,the mechanisms by wh... The content of total flavonoids in an extract of Ginkgo biloba,called GBE50,is 44%by weight.This is significantly greater than that in a standard extract of Ginkgo biloba,designated EGB761.To date,the mechanisms by which GBE50 and EGB761 function remain poorly understood.In the present study,an experimental rat model of aging was induced by intraperitoneal injection of D-galactose,followed by intragastric perfusion of GBE50(30,60 mg/kg),or EGB761(60 mg/kg).The water maze scores and hippocampal CA1 synaptic plasticity were evaluated.In the place navigation test,the GBE50 group rats did better than EGB761,while similar scores were obtained in the spatial probe test,and in the platform-switched test.In addition,long-term potentiation was significantly enhanced following high-frequency stimulation in the GBE50 and EGB761 groups,compared with the model group.These results demonstrate that GBE50 and EGB761 improved the learning and memory of aging rats.In particular,GBE50 administered at the 60 mg/kg dose exhibited superior effects over EGB761 at the same 60 mg/kg dose.Furthermore,the enhancement of hippocampal synaptic plasticity may be an underlying mechanism. 展开更多
关键词 aging GBE 50 memory impairment hippocampus long-term potentiation neural regeneration
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Transparent electromagnetic interference shielding materials using MXene 认领 引用 被引量：12
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作者 Yanli Deng Yaqing Chen +8 位作者 Wei Liu Lili Wu Zhou Wang Dan Xiao Decheng Meng Xingguo Jiang Jiurong Liu Zhihui Zeng Na Wu 《Carbon Energy》 SCIE EI CAS CSCD 2024年第11期322-345,共24页
With the rapid advancement of terahertz technologies,electromagnetic interference(EMI)shielding materials are needed to ensure secure electromagnetic environments.Enormous efforts have been devoted to achieving highly... With the rapid advancement of terahertz technologies,electromagnetic interference(EMI)shielding materials are needed to ensure secure electromagnetic environments.Enormous efforts have been devoted to achieving highly efficient EMI shielding films by enhancing flexibility,lightweight,mechanical robustness,and high shielding efficiency.However,the consideration of the optical properties of these shielding materials is still in its infancy.By incorporating transparency,visual information from protected systems can be preserved for monitoring interior working conditions,and the optical imperceptibility allows nonoffensive and easy cover of shielding materials for both device and biology.There are many materials that can be applied to transparent EMI shields.In particular,two-dimensional transition metal carbideitrides(MXenes),possessing the advantages of superior conductivity,optical properties,favorable flexibility,and facile processibility,have become a great candidate.This work reviews the recent research on developing highly efficient and optically transparent EMI shields in a comprehensive way.Materials from MXenes,indium tin oxide,metal,carbon,and conductive polymers are covered,with a focus on the employment of MXene-based composites in transparent EMI shielding.The prospects and challenges for the future development of MXene-based transparent EMI shields are discussed.This work aims to promote the development of high-performance,optically transparent EMI shields for broader applications by leveraging MXenes. 展开更多
关键词 electromagnetic waves transition metal carbidesitrides transparent electromagnetic shielding materials
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Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice 认领 引用 被引量：9
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作者 Juane Li Tonghua Liu +5 位作者 Lei Wang Xiangyu Guo Tunhai Xu Lili Wu Lingling Qin Wen Sun 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2012年第3期446-452,共7页
OBJECTIVE:To investigate the effects of cinnamaldehyde(CA),an active and major compound in cinnamon,on glucose metabolism and insulin resistance in C57BLKS/J db/db mice.METHODS:Sixteen male C57BLKS db/db mice were ran... OBJECTIVE:To investigate the effects of cinnamaldehyde(CA),an active and major compound in cinnamon,on glucose metabolism and insulin resistance in C57BLKS/J db/db mice.METHODS:Sixteen male C57BLKS db/db mice were randomly divided into control and CA treatment groups.CA was given(20 mg.kg-1.day-1,p.o.) for 4 weeks.Pure water was given to control and db/+ mice.Subsequently,the levels of fasting blood glucose(FBG),fasting serum insulin,triglyeride,cholesterol,low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),and free fatty acids(FFA),as well as the mRNA content of adiponectin and tumor necrosis factor(TNF)-α in adipose tissue,glucose transporter type 4(GLUT-4) in skeletal muscle,and protein expressions of Akt,phospho-Akt(Thr308),AMPKα,phospho-AMPKα(Thr172) in skeletal muscle were measured.RESULTS:1) CA decreased serum levels of FBG and insulin as well as body weight in db/db mice;2) CA increased serum HDL-C levels;3) CA significantly decreased the mRNA expression of TNF-α in adipose tissue and upregulated mRNA expression of GLUT-4 in skeletal muscle;4) protein expression of p-Akt was increased in CA-treated mice,but Akt,AMPKα and p-AMPKα showed no change.CONCLUSION:CA has antihyperglycemic and antihyperlipidemic actions in db/db mice and could be useful in the treatment of type-2 diabetes. 展开更多
关键词 Cinnamaldehyde Diabetes mellitus,Type 2 Insulin resistance
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Tailoring the Spatial Distribution and Content of Inorganic Nitrides in Solid-Electrolyte Interphases for the Stable Li Anode in Li-S Batteries 认领 引用 被引量：5
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作者 Qi Jin Kaixin Zhao +3 位作者 Lu Li Xinzhi Ma Lili Wu Xitian Zhang 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2022年第4期1180-1188,共9页
Among the alternatives to lithium-ion batteries,lithium-sulfur(Li-S)batteries are considered as an attractive option because of their high theoretical energy density of 2570 Wh kg−1.However,the application of the L... Among the alternatives to lithium-ion batteries,lithium-sulfur(Li-S)batteries are considered as an attractive option because of their high theoretical energy density of 2570 Wh kg−1.However,the application of the Li-S battery has been plagued by the rapid failure of the Li anode due to the Li dendrite growth and severe parasitic reactions between Li and lithium polysulfides.The physicochemical properties of the solid-electrolyte interphase have a profound impact on the performance of the Li anode.Herein,a lithium polyacrylic acid/lithium nitrate(LPL)-protective layer is developed to inhibit the dendrite Li growth and parasitic reactions by tailoring the spatial distribution and content of LiNxOy and Li3N at the SEI.The modified SEI is thoroughly investigated for compositions,ion transport properties,and Li plating/stripping kinetics.Consequently,the Li-S cell with a high S loading cathode(5.0 mg cm−2),LPL layer-protected thin Li anode(50μm),and 40μL electrolyte shows a long life span of 120 cycles.This work evokes the avenue for regulating the spatial distribution of inorganic nitride at the SEI to suppress the formation of Li dendrites and parasitic reactions in Li-S batteries and perhaps guiding the design of analogous battery systems. 展开更多
关键词 Li anode Li dendrites LiPAA/LiNO3layer SEI shuttle effect
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Enhancing Li cycling coulombic efficiency while mitigating “shuttle effect” of Li-S battery through sustained release of LiNO3 认领 引用 被引量：3
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作者 Qi Jin Kaixin Zhao +3 位作者 Lili Wu Lu Li Long Kong Xitian Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第9期22-29,共8页
In practical lithium-sulfur batteries(LSBs),the shuttle effect and Li cycling coulombic efficiency(CE) are strongly affected by the physicochemical properties of solid electrolyte interphase(SEI).LiNO3 is widely us... In practical lithium-sulfur batteries(LSBs),the shuttle effect and Li cycling coulombic efficiency(CE) are strongly affected by the physicochemical properties of solid electrolyte interphase(SEI).LiNO3 is widely used as an additive in electrolytes to build a high-quality SEI,but its self-sacrificial nature limits the ability to mitigate the shuttle effect and stabilize Li anode during long-term cycling.To counteract LiNO3 consumption during long-term cycling without using a high initial concentration,inspired by sustainedrelease drugs,we encapsulated LiNO3 in lithiated Nafion polymer and added an electrolyte co-solvent(1,1,2,2-tetrafluoroethylene 2,2,2-trifluoromethyl ether) with poor LiNO3 solubility to construct highquality and durable F-and N-rich SEI.Theoretical calculations,experiments,multiphysics simulations,and in-situ observations confirmed that the F-and N-rich SEI can modulate lithium deposition behavior and allow persistent repair of SEI during prolonged cycling.Hence,the F-and N-rich SEI improves the Li anode cycling CE to 99.63% and alleviates the shuttle effect during long-term cycling.The lithium anode with sustainable F-and N-rich SEI shows a stable Li plating/stripping over 2000 h at 1 mA cm-2.As expected,Li‖S full cells with this SEI achieved a long lifespan of 250 cycles,far exceeding cells with a routine SEI.The Li‖S pouch cell based on F-and N-rich SEI also can achieve a high energy density of about300 Wh kg-1 at initial cycles.This strategy provides a novel design for high-quality and durable SEls in LSBs and may also be extendable to other alkali metal batteries. 展开更多
关键词 Lithium-sulfur battery Solid electrolyte interphase LiNO3 Coulombic efficiency Shuttle effect
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