Background:Bullying victimization(BV)represents a critical public health concern among Chinese adolescents,with significant implications for psychological well-being.Although accumulating evidence underscores the detr...Background:Bullying victimization(BV)represents a critical public health concern among Chinese adolescents,with significant implications for psychological well-being.Although accumulating evidence underscores the detrimental association between maladaptive parenting practices and increased bullying victimization,the precise mediating mechanisms linking parental psychological control(PPC)to BV remain inadequately elucidated.This study addresses this gap by examining pathways through which PPC and deviant peer affiliation(DPA)jointly influence BV,while accounting for the protective role of self-compassion(SC).Methods:A sample of 861 Chinese adolescents(429 male;mean age=14.08 years,SD=1.07)recruited via a convenience sampling method completed validated self-report measures assessing PPC,DPA,SC,and BV frequency.Results:PPC is significantly associated with higher levels of BV(β=0.268,p<0.001).Crucially,structural equation modeling revealed that DPA partially mediated this relationship(β=0.043,p<0.01),indicating that PPC is positively associated with BV,and this association is mediated by DPA.Further moderation analyses identified SC as a buffering factor(β=-0.077,SE=0.038,p<0.05):Only adolescents with lower SC exhibited strengthened indirect effects of PPC on BV via DPA.This suggests SC mitigates the pathway from coercive parenting to risky peer associations.Conclusion:These findings contribute novel insights into multifaceted risk and protective factors for BV.PPC appears to function as a distal familial factor associated with adolescents’victimization experiences through peer-related processes,whereas SC emerges as an intrapersonal resilience-related factor.The study underscores the adverse consequences of psychologically controlling parenting and provides empirical support for targeted interventions.展开更多
To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective dis...To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.展开更多
BACKGROUND The role of cerebral microvascular dysfunction in early cognitive impairment and dementia has become increasingly recognized.Furthermore,pathological changes in both Alzheimer’s disease and vascular dement...BACKGROUND The role of cerebral microvascular dysfunction in early cognitive impairment and dementia has become increasingly recognized.Furthermore,pathological changes in both Alzheimer’s disease and vascular dementia are almost always associated with cerebral hemodynamic deficits.AIM To investigate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)assessment of the blood-brain barrier(BBB)in combination with relevant plasma biomarkers for mild cognitive impairment(MCI).METHODS This study selected 50 patients with non-amnestic MCI(na-MCI group),52 patients with amnestic MCI(a-MCI group),and 55 healthy elderly controls(control group).The Chinese version of the Montreal cognitive assessment(MoCA),auditory verbal learning test(AVLT),Hamilton anxiety/depression scale(HAMA/HAMD),and activity of daily living(ADL)scales were used to analyze the characteristics of mental and behavioral symptoms of patients with MCI.The DCE-MRI technique was used to assess the contrast enhancement kinetics.The Patlak model was utilized to analyze the BBB permeability(volume transfer constants).Further,fasting blood was was used to quantify plasma homocysteine(Hcy),β-amyloid protein(Aβ)40,Aβ42,human phosphorylated tau-181 protein(p-tau181),intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1),and plasminogen activator inhibitor-1(PAI-1)levels,as well as serum neurofilament light chain(NFL)and glial fibrillary acidic protein(GFAP)concentrations.RESULTS The na-MCI and a-MCI groups demonstrated significantly lower MoCA and AVLT-Huashan version scores,and statistically higher HAMA,HAMD,and ADL scores compared to the control group.Moreover,the a-MCI group showed notably higher HAMA,HAMD,and ADL scores compared to the na-MCI group.Cranial MRI results revealed significant disparities in cerebral blood flow in the left and right frontal lobes,temporal lobes,hippocampi,cuneus,precuneus,parietal lobes,basal ganglia,and occipital lobes between the a-MCI and na-MCI groups.Compared to healthy controls,patients with MCI demonstrated a smaller amplitude of hippocampal contrast enhancement kinetics and a slower decay rate,indicating smaller vascular volume and increased BBB permeability.Further,Hcy,p-tau181,ICAM-1,VCAM-1,PAI-1,and NFL levels were substantially higher in the a-MCI group than in the na-MCI group,whereas the Aβ42 level was significantly lower.We did not observe any significant differences in Aβ40 and GFAP levels.CONCLUSION Patients with MCI may have experienced cerebrovascular system changes in the hippocampal region.Disorders associated with changes in cerebral blood supply may begin before pathophysiological changes are visible by imaging,which provides references for the assessment and treatment of patients with cognitive disorders.Further,DCE-MRI provides a noninvasive approach to diagnose subtle BBB leakage associated with cerebrovascular pathology.展开更多
Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to ...Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to their ability to suppress the inflammatory cascades.In this study,extensive screening of an in-house library of 1200 Chinese medicinal plant extracts identified Platycladus orientalis(L.)Franco(P.orientalis)as a potent PDE4 inhibitor,exhibiting 42.7%inhibition at 0.2μg/m L.Subsequent bioassayguided isolation revealed flavonoids,particularly amentoflavone(AMF),as the principal component responsible for PDE4 inhibition.To enrich the effective ingredients,a purification protocol using microporous resin was developed,yielding a flavonoid-rich extract(FLDs)that efficiently increased AMF content from 6.2%to 72.3%and improved PDE4 inhibitory activity to 74.2%at 0.2μg/mL.Notably,P.orientalis with favorable safety profiles demonstrated superior in vitro and in vivo anti-psoriasis effects to both AMF and the approved PDE4 inhibitor apremilast.These findings highlight the potential of P.orientalis as a novel therapeutic agent for psoriasis and provide valuable insights for its development in psoriasis treatment.展开更多
Objective:The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis(PAS)in pediatric patients after surgical repair of comp...Objective:The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis(PAS)in pediatric patients after surgical repair of complicated congenital heart diseases(CHDs).Methods:All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study.Results:A total of 41 patients(30 males,11 females;median age 5.0 years,median weight 17 kg)were followed-up for a median of 7.1 years.Follow-up echocardiography results demonstrated that the target vessel diameter increased from(3.4±1.1)mm preoperatively to(6.2±1.9)mm one year post-procedure and(6.0±1.5)mm at the final follow-up(p72 mmHg)was significantly associated with long-term adverse events(p=0.024).Conclusion:Percutaneous stent implantation for residual PAS after surgical repair of complicated CHDs effectively relieves vessel stenosis,stabilizes cardiac function,and improves long-term prognosis in pediatric patients.In-stent restenosis remains an unresolved complication,necessitating further advancements in interventional strategies.展开更多
The steel-epoxy-steel sandwich structures provide enhanced corrosion resistance and fatigue resistance,making them suitable for pipeline rehabilitation with effective repair and long-term durability.However,the repair...The steel-epoxy-steel sandwich structures provide enhanced corrosion resistance and fatigue resistance,making them suitable for pipeline rehabilitation with effective repair and long-term durability.However,the repair quality can be compromised by disbond between the steel and epoxy layers,whichmay result frominsufficient epoxy injection.Conventional ultrasonic testing faces challenges in accurately locating disbond defects due to aliased echo interference at interfaces.This paper proposes a signal processing algorithm for improving the accuracy of ultrasonic reflection method for detecting disbond defects between steel and epoxy layers.First,a coati optimization algorithmvariational mode decomposition(COA-VMD)is applied to adaptively decompose the ultrasonic signals and extract the intrinsic mode function components that show high correlation with the defect-related signals.Then,by calculating the relative reflectance at the interface and establishing a quantitative evaluation index based on acoustic impedance discontinuity,the locations of disbond defects are identified.Experimental results demonstrate that this method can effectively detect the locations of disbond defects between steel and epoxy layers.展开更多
In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satelli...In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated.展开更多
Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacanc...Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacancy of the global early-morning-orbit satellite observation,working together with the FY-3C and FY-3D satellites to achieve the data coverage of early morning,morning,and afternoon orbits.The combination of these three satellites will provide global data coverage for numerical weather prediction(NWP)at 6-hour intervals,effectively improving the accuracy and time efficiency of global NWP,which is of great significance to perfect the global earth observing system.In this article,the background and meteorological requirements for the early-morning-orbit satellite are reviewed,and the specifications of the FY-3E satellite,as well as the characteristics of the onboard instrumentation for earth observations,are also introduced.In addition,the ground segment and the retrieved geophysical products are also presented.It is believed that the NWP communities will significantly benefit from an optimal temporal distribution of observations provided by the early morning,mid-morning,and afternoon satellite missions.Further benefits are expected in numerous applications such as the monitoring of severe weather/climate events,the development of improved sampling designs of the diurnal cycle for accurate climate data records,more efficient monitoring of air quality by thermal infrared remote sensing,and the quasicontinuous monitoring of the sun for space weather and climate.展开更多
Microwave Land Surface Emissivity(MLSE)over China under both clear and cloudy sky conditions was retrieved using measurements of recalibrated microwave brightness temperatures(Tbs)from Fengyun-3B Microwave Radiation I...Microwave Land Surface Emissivity(MLSE)over China under both clear and cloudy sky conditions was retrieved using measurements of recalibrated microwave brightness temperatures(Tbs)from Fengyun-3B Microwave Radiation Imager(FY-3B MWRI),combined with cloud properties derived from Himawari-8 Advanced Himawari Imager(AHI)observations.The contributions from cloud particles and atmospheric gases to the upwelling Tbs at the top of atmosphere were calculated and removed in radiative transfer.The MLSEs at horizontal polarizations at 10.65,18.7,and 36.5 GHz during 7 July 2015 to 30 June 2019 over China showed high values in the southeast vegetated area and low values in the northwest barren,or sparsely vegetated,area.The maximum values were found in the belt area of the Qinling-Taihang Mountains and the eastern edge of the Qinghai-Tibet Plateau,which is highly consistent with MLSEs derived from AMSR-E.It demonstrates that the measurements of FY-3B MWRI Tbs,including its calibration and validation,are reliable,and the retrieval algorithm developed in this study works well.Seasonal variations of MLSE in China are mainly driven by the combined effects of vegetation,rainfall,and snow cover.In tropical and southern forest regions,the seasonal variation of MLSE is small due to the enhancement from vegetation and the suppression from rainfall.In the boreal area,snow causes a significant decrease of MLSE at 36.5 GHz in winter.Meanwhile,the MLSE at lower frequencies experiences less suppression.In the desert region in Xinjiang,increases of MLSEs at all frequencies are observed with increasing snow cover.展开更多
Considering the increased anthropogenic impacts,species with a limited range and low detectability often lack fundamental information and conservation actions,placing them at a high risk of endangerment.The Chinting a...Considering the increased anthropogenic impacts,species with a limited range and low detectability often lack fundamental information and conservation actions,placing them at a high risk of endangerment.The Chinting alpine toad Scutiger chintingensis is a rare mountain amphibian endemic to the eastern margin of the Qinghai-Xizang Plateau in China.Within its whole distribution range,only three known populations(Wolong,Emei,and Wawu)exist and no recent population status report has been documented for this species over the past two decades.From 2020 to 2023,we investigated the species distribution,and assessed the risk factors for the main populations.We recorded this species in all distribution areas,and updated a new distribution site with a lower elevation limit.The relative population density was 0.024±0.012 ind./m2on Mount Emei,whereas only 0.008±0.017 ind./m2on Mount Wawu.No significant difference was observed in the number of individuals between the two populations;however,the relative population density was significantly different.Sewage and waste discharge resulting from the construction of scenic areas,as well as disturbances from tourism,were the primary anthropogenic factors that influenced the survival of this species.Our results provide the updated information on the distribution and population status of the Chinting alpine toad,and suggest that unrecorded populations,as well as a wider elevation range,may exist for this species.Our findings emphasise the importance of timely updates of species distribution and population information and offer a basis for the future conservation of endangered amphibians.展开更多
Here in this paper,we report a room-temperature operating infrared photodetector based on the interband transition of an In As Sb/Ga Sb quantum well.The interband transition energy of 5-nm thick In As(0.91)Sb(0.09...Here in this paper,we report a room-temperature operating infrared photodetector based on the interband transition of an In As Sb/Ga Sb quantum well.The interband transition energy of 5-nm thick In As(0.91)Sb(0.09) embedded in the Ga Sb barrier is calculated to be 0.53 e V(2.35μm),which makes the absorption range of In As Sb cover an entire range from short-wavelength infrared to long-wavelength infrared spectrum.The fabricated photodetector exhibits a narrow response range from 2.0μm to 2.3μm with a peak around 2.1μm at 300 K.The peak responsivity is 0.4 A/W under-500-m Vapplied bias voltage,corresponding to a peak quantum efficiency of 23.8%in the case without any anti-reflection coating.At 300 K,the photodetector exhibits a dark current density of 6.05×10^-3A/cm^2 under-400-m V applied bias voltage and 3.25×10^-5A/cm^2 under zero,separately.The peak detectivity is 6.91×10^10cm·Hz^1/2/W under zero bias voltage at 300 K.展开更多
The first TEMPO-mediated'living'free radical polymerization of liquid crystalline monomer,2,5-bis[(4-methoxyphenyl)oxycarbonyl]styrene(MPCS),was carried out at 130 degrees C with BPO as an initiator.The molecu...The first TEMPO-mediated'living'free radical polymerization of liquid crystalline monomer,2,5-bis[(4-methoxyphenyl)oxycarbonyl]styrene(MPCS),was carried out at 130 degrees C with BPO as an initiator.The molecular weight of the polymer can be varied from rather low values to high values while maintaining narrow polydispersity.It was observed that the polymerization of MPCS proceeded much faster than that of styrene.A tentative explanation for this fast polymerization was suggested.展开更多
The synergism effect of total ionizing dose(TID) on a single event transient(SET) in a bipolar comparator is investigated. Experimental results show that the shapes of the SET are considerably influenced by the TI...The synergism effect of total ionizing dose(TID) on a single event transient(SET) in a bipolar comparator is investigated. Experimental results show that the shapes of the SET are considerably influenced by the TID accumulated in low dose rates. The variation tendency of SET shapes can be accurately simulated by temperature switching irradiation. The mechanism of this synergism effect is also analyzed in brief via the operating schematic of a comparator. After the accumulation of 100 krad(Si), the lower tendency of negative SET can be attributed to the degeneration of . The change tendency of a positive SET, either lower or higher, is dependent on the load condition that limits the output range of the comparator.展开更多
BACKGROUND Improper methods of contraception greatly increase the risk of abortion,cervical or endometrial lesions,and the number of recurrent artificial abortions.These complications result in the deterioration of a ...BACKGROUND Improper methods of contraception greatly increase the risk of abortion,cervical or endometrial lesions,and the number of recurrent artificial abortions.These complications result in the deterioration of a patient’s outcome.Further,the proportion of artificial abortions is highest among unmarried females.Placement of an intrauterine device,such as the Mirena,after an artificial abortion may decrease the likelihood of an endometrial injury caused by recurrent abortions while significantly improving its contraceptive effects.AIM To discuss the effect of Mirena placement on reproductive hormone levels at different time points after an artificial abortion.METHODS Women(n=119)undergoing an artificial abortion operation were divided into the study(n=56)and control(n=63)groups.In the study group,the Mirena was inserted immediately after the artificial abortion,whereas in the control group,it was inserted 4–7 d after the onset of the first menstrual cycle after abortion.All participants were followed-up for 6 mo to observe the continuation and expulsion rates and adverse reactions and to measure the levels of serum estradiol(E2),follicle stimulating hormone(FSH),and luteinizing hormone(LH).RESULTS The continuation rates were 94.64%and 93.65%in the study group and the control group,respectively.The expulsion rates were 1.79%and 3.17%in the study group and the control group,respectively.There was no statistically significant difference between the two groups(P>0.05).There were also no statistically significant differences in the proportion of patients with bacterial vaginitis,trichomonas vaginitis,or cervicitis between the groups(P>0.05).Six months after Mirena placement,E2 Levels were 45.50±7.13 pg/mL and 42.91±8.10 pg/mL,FSH 13.60±3.24 mIU/mL and 14.54±3.11 mIU/mL,and LH 15.11±2.08 mIU/mL and 14.60±3.55 mIU/mL in the study and control groups,respectively.There were no significant differences in hormone levels between the two groups(P>0.05).There were also no statistically significant differences in the proportions of abnormal menstruation,prolonged menstruation,or pain during intercourse between the study and control groups after Mirena placement(P>0.05).There were no statistically significant differences in uterine volume,sexual desire,sexual activity,or the sexual satisfaction score between the study and control groups before and after Mirena placement(P>0.05).CONCLUSION Placement of a Mirena intrauterine device immediately after an artificial abortion does not increase the risk of adverse reactions and can help prevent endometrial injury caused by recurrent abortions.展开更多
BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent obesity.AIM To investigate the relationship between sleep ...BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent obesity.AIM To investigate the relationship between sleep rhythm and obesity among adolescents and further explores the interactive effect of sleep rhythm and gender on adolescent obesity,providing a theoretical basis for developing interventions for adolescent obesity.METHODS Research data source Tianjin Mental Health Promotion Program for Students.From April to June 2022,this study selected 14201 students from 13 middle schools in a certain district of Tianjin as the research subject using the convenient cluster sampling method.Among these students,13374 accepted and completed the survey,with an effective rate of 94.2%.The demographic data and basic information of adolescents,such as height and weight,were collected through a general situation questionnaire.The sleep rhythm of adolescents was evaluated using the reduced version of the morningness-eveningness questionnaire.RESULTS A total of 13374 participants(6629 females,accounting for 49.56%;the average age is 15.21±1.433 years)were analyzed.Among them,the survey showed that 2942 adolescent were obesity,accounting for 22%and 2104 adolescent were overweight,accounting for 15.7%.Among them,1692 male adolescents are obese,with an obesity rate of 25.1%,higher than 18.9%of female adolescents.There is a statistically significant difference between the three groups(χ2=231.522,P<0.000).The obesity group has the smallest age(14.94±1.442 years),and there is a statistical difference in age among the three groups(F=69.996,P<0.000).Obesity rates are higher among individuals who are not-only-child,have residential experience within six months,have family economic poverty,and have evening-type sleep(P<0.05).Logistic regression analysis shows a correlation between sleep rhythm and adolescent obesity.Evening-type sleep rhythm can increase the risk of obesity in male adolescents[1.250(1.067-1.468)],but the effect on female obesity is not remarkable.Further logistic regression analysis in the overall population demonstrates that the interaction between evening-type sleep rhythm and the male gender poses a risk of adolescent obesity[1.122(1.043-1.208)].CONCLUSION Among adolescents,the incidence of obesity in males is higher than in females.Evening-type sleep rhythm plays an important role in male obesity but has no significant effect on female obesity.Progressive analysis suggests an interactive effect of sleep rhythm and gender on adolescent obesity,and the combination of evening-type sleep and the male gender promotes the development of adolescent obesity.In formulating precautions against adolescent obesity,obesity in male adolescents with evening-type sleep should be a critical concern.展开更多
Graphene oxide(GO)is one typical two-dimension structured and oxygenated planar molecular material.Researchers across multiple disciplines have paid enormous attention to it due to the unique physiochemical properties...Graphene oxide(GO)is one typical two-dimension structured and oxygenated planar molecular material.Researchers across multiple disciplines have paid enormous attention to it due to the unique physiochemical properties.However,models used to describe the structure of GO are still in dispute and ongoing to update.And currently,synthesis methods for mass production are seemingly abundant but in fact,dominated by a few core methodologies.To update with the state-of-art opinions and progresses,herein we present a mini critical review regarding the synthesis of GO as well as its models and simulations of structure.Also,we discuss the perspectives.展开更多
Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve th...Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve the autonomous navigation ability of mobile robots and their adaptability to different application environments and contribute to the realization of real-time obstacle avoidance and dynamic path planning.Moreover,the application of SLAM technology has expanded from industrial production,intelligent transportation,special operations and other fields to agricultural environments,such as autonomous navigation,independent weeding,three-dimen-sional(3D)mapping,and independent harvesting.This paper mainly introduces the principle,sys-tem framework,latest development and application of SLAM technology,especially in agricultural environments.Firstly,the system framework and theory of the SLAM algorithm are introduced,and the SLAM algorithm is described in detail according to different sensor types.Then,the devel-opment and application of SLAM in the agricultural environment are summarized from two aspects:environment map construction,and localization and navigation of agricultural robots.Finally,the challenges and future research directions of SLAM in the agricultural environment are discussed.展开更多
AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets we...AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets were subjected ex vivo to physiologic FSS,supra-physiologic FSS magnitude at normal frequency and supra-physiologic FSS frequency at normal magnitude for 48 h in a double-sided cone-and-plate bioreactor filled with standard culture medium. The role of BMP-4 and TGF-β1 in the valvular response was investigated by promoting or inhibiting the downstream action of those cytokines via culture medium supplementation with BMP-4 or the BMP antagonist noggin,and TGF-β1 or the TGF-β1 inhibitor SB-431542,respectively. Fresh porcine leaflets were used as controls. Each experimental group consisted of six leaflet samples. Immunostaining and immunoblotting were performed to assess endothelial activation in terms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressions,paracrine signaling in terms of BMP-4 and TGF-β1 expressions and extracellular matrix(ECM) remodeling in terms of cathepsin L,cathepsin S,metalloproteinases(MMP)-2 and MMP-9 expressions. Immunostained images were quantified by normalizing the intensities of positively stained regions by the number of cells in each image while immunoblots were quantified by densitometry. R E S U LT S :Regardless of the culture medium,physiologic FSS maintained valvular homeostasis. Tissue exposure to supra-physiologic FSS magnitude in standard medium stimulated paracrine signaling(TGF-β1:467% ± 22% vs 100% ± 6% in freshcontrols,BMP-4:258% ± 22% vs 100% ± 4% in fresh controls; P 0.05). Supra-physiologic FSS frequency had no effect on endothelial activation and paracrine signaling regardless of the culture medium but TGF-β1 silencing attenuated FSS-induced ECM degradation via MMP-9 downregulation(MMP-9:302% ± 182% vs 100% ± 42% in fresh controls; P > 0.05).CONCLUSION:Valvular tissue is sensitive to FSS abnormalities. The TGF-β1 inhibitor SB-431542 is a potential candidate molecule for attenuating the effects of FSS abnormalities on valvular remodeling.展开更多
Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids ...Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids DALZ 1701,DALZ 1713,and'Innovation',and two Z.minima×Z.matrella hybrids(DALZ 1309 and'Lazer').Treatments included a control(nutrient solution)and two saline treatments representing moderate and high salt levels.The electrical conductivity(EC)was 1.3 dS m−1 for control and moderate(EC5)and high salinity(EC10)were 5.0 and 10.0 dS m−1,respectively.At the end of eight-weeks of treatment,the relative(percent control)shoot dry weight(DW)was greatest in'Diamond'in EC10,and the relative root DW was greatest in DALZ 1309 in EC5.A cluster analysis based on the relative tissue dry weight identified'Diamond',DALZ 1309,and DALZ 1713 as the most salt tolerant genotypes.Additionally,the green leaf area(GLA)index of'Diamond'and DALZ 1713 were 98.8%and 100%,respectively,indicating excellent visual appearance under high salt levels.Bi-weekly clipping DW showed that'Diamond'continued to produce biomass throughout the duration of the study under the EC10 treatment.Sodium(Na+)and chloride(Cl−)content in the shoot tissue of the seven turfgrass genotypes indicated that lower concentrations corresponded to greater salt tolerance indicating exclusion of Na+and Cl−from the shoot tissue.Taken together,the genotypes'Diamond'and DALZ 1713 were determined to be the most salt tolerant and recommended for use in areas with high soil or water salinity.展开更多
For oviparous species with little or no parental care, oviposition site choice may be a powerful agent of natural selection, playing an important role in the evolution of species fitness and life history. Identifying ...For oviparous species with little or no parental care, oviposition site choice may be a powerful agent of natural selection, playing an important role in the evolution of species fitness and life history. Identifying and clarifying the microhabitat characteristics of oviposition sites are key to understanding life history strategies and local adaptations for amphibians with complex biphasic life cycles. However, oviposition strategies for amphibians in alpine streams remain poorly understood. Here, we focused on oviposition site selection for the Chinting alpine toad(Scutiger chintingensis) on Mount Wawu on the eastern margin of the Qinghai-Xizang Plateau. We identified the microhabitat differences between oviposition sites and non-oviposition sites for this species, predicted oviposition site selection patterns,and evaluated the relative importance of each microhabitat variable as well as the effects of the variables on the model prediction probabilities. This study revealed that the microhabitat characteristics of oviposition sites in this species included high water velocity, shallow water, and high-water surface coverage. Water velocity and rock volume were the most important variables explaining the categories of oviposition sites. Additionally, we observed nearly half the proportion of overlapping oviposition in this species, and the benefits of this behavior in terms of microhabitat characteristics need to be explored in the future. Our study revealed an oviposition site selection strategy for amphibians within alpine streams, and contributed to understanding the life history and environmental adaptation strategies of an endemic alpine stream species, and thereby providing guidance for effective conservation strategies for alpine stream amphibians under global change.展开更多
基金approved by the Ethics Committee of the Faculty of Psychology,Beijing Normal University(No.BNU202503110083)Informed consent was obtained from all participants’parents/guardians and school authorities prior to the study.
摘要Background:Bullying victimization(BV)represents a critical public health concern among Chinese adolescents,with significant implications for psychological well-being.Although accumulating evidence underscores the detrimental association between maladaptive parenting practices and increased bullying victimization,the precise mediating mechanisms linking parental psychological control(PPC)to BV remain inadequately elucidated.This study addresses this gap by examining pathways through which PPC and deviant peer affiliation(DPA)jointly influence BV,while accounting for the protective role of self-compassion(SC).Methods:A sample of 861 Chinese adolescents(429 male;mean age=14.08 years,SD=1.07)recruited via a convenience sampling method completed validated self-report measures assessing PPC,DPA,SC,and BV frequency.Results:PPC is significantly associated with higher levels of BV(β=0.268,p<0.001).Crucially,structural equation modeling revealed that DPA partially mediated this relationship(β=0.043,p<0.01),indicating that PPC is positively associated with BV,and this association is mediated by DPA.Further moderation analyses identified SC as a buffering factor(β=-0.077,SE=0.038,p<0.05):Only adolescents with lower SC exhibited strengthened indirect effects of PPC on BV via DPA.This suggests SC mitigates the pathway from coercive parenting to risky peer associations.Conclusion:These findings contribute novel insights into multifaceted risk and protective factors for BV.PPC appears to function as a distal familial factor associated with adolescents’victimization experiences through peer-related processes,whereas SC emerges as an intrapersonal resilience-related factor.The study underscores the adverse consequences of psychologically controlling parenting and provides empirical support for targeted interventions.
基金the Tianjin Health Research Project(Grant No.TJWJ2023MS038)Tianjin Education Commission Research Project(Grant No.2023KJ044)S&T Program of Hebei(SG2021189)。
摘要To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.
摘要BACKGROUND The role of cerebral microvascular dysfunction in early cognitive impairment and dementia has become increasingly recognized.Furthermore,pathological changes in both Alzheimer’s disease and vascular dementia are almost always associated with cerebral hemodynamic deficits.AIM To investigate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)assessment of the blood-brain barrier(BBB)in combination with relevant plasma biomarkers for mild cognitive impairment(MCI).METHODS This study selected 50 patients with non-amnestic MCI(na-MCI group),52 patients with amnestic MCI(a-MCI group),and 55 healthy elderly controls(control group).The Chinese version of the Montreal cognitive assessment(MoCA),auditory verbal learning test(AVLT),Hamilton anxiety/depression scale(HAMA/HAMD),and activity of daily living(ADL)scales were used to analyze the characteristics of mental and behavioral symptoms of patients with MCI.The DCE-MRI technique was used to assess the contrast enhancement kinetics.The Patlak model was utilized to analyze the BBB permeability(volume transfer constants).Further,fasting blood was was used to quantify plasma homocysteine(Hcy),β-amyloid protein(Aβ)40,Aβ42,human phosphorylated tau-181 protein(p-tau181),intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1),and plasminogen activator inhibitor-1(PAI-1)levels,as well as serum neurofilament light chain(NFL)and glial fibrillary acidic protein(GFAP)concentrations.RESULTS The na-MCI and a-MCI groups demonstrated significantly lower MoCA and AVLT-Huashan version scores,and statistically higher HAMA,HAMD,and ADL scores compared to the control group.Moreover,the a-MCI group showed notably higher HAMA,HAMD,and ADL scores compared to the na-MCI group.Cranial MRI results revealed significant disparities in cerebral blood flow in the left and right frontal lobes,temporal lobes,hippocampi,cuneus,precuneus,parietal lobes,basal ganglia,and occipital lobes between the a-MCI and na-MCI groups.Compared to healthy controls,patients with MCI demonstrated a smaller amplitude of hippocampal contrast enhancement kinetics and a slower decay rate,indicating smaller vascular volume and increased BBB permeability.Further,Hcy,p-tau181,ICAM-1,VCAM-1,PAI-1,and NFL levels were substantially higher in the a-MCI group than in the na-MCI group,whereas the Aβ42 level was significantly lower.We did not observe any significant differences in Aβ40 and GFAP levels.CONCLUSION Patients with MCI may have experienced cerebrovascular system changes in the hippocampal region.Disorders associated with changes in cerebral blood supply may begin before pathophysiological changes are visible by imaging,which provides references for the assessment and treatment of patients with cognitive disorders.Further,DCE-MRI provides a noninvasive approach to diagnose subtle BBB leakage associated with cerebrovascular pathology.
基金supported by the National Key R&D Program of China(No.2023YFF1205102)National Natural Science Foundation of China(Nos.22277019,22307031,22377023 and 22077143)+2 种基金the Fundamental Research Funds for Hainan University(Nos.RZ2200001094,KYQD(ZR)-21031,and KYQD(ZR)-21108)Collaborative Innovation Center Funds for Hainan University(No.XTCX2022JKA01)the Science Foundation of Hainan Province(Nos.KJRC2023B10 and 824YXQN420)。
摘要Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to their ability to suppress the inflammatory cascades.In this study,extensive screening of an in-house library of 1200 Chinese medicinal plant extracts identified Platycladus orientalis(L.)Franco(P.orientalis)as a potent PDE4 inhibitor,exhibiting 42.7%inhibition at 0.2μg/m L.Subsequent bioassayguided isolation revealed flavonoids,particularly amentoflavone(AMF),as the principal component responsible for PDE4 inhibition.To enrich the effective ingredients,a purification protocol using microporous resin was developed,yielding a flavonoid-rich extract(FLDs)that efficiently increased AMF content from 6.2%to 72.3%and improved PDE4 inhibitory activity to 74.2%at 0.2μg/mL.Notably,P.orientalis with favorable safety profiles demonstrated superior in vitro and in vivo anti-psoriasis effects to both AMF and the approved PDE4 inhibitor apremilast.These findings highlight the potential of P.orientalis as a novel therapeutic agent for psoriasis and provide valuable insights for its development in psoriasis treatment.
基金approved by the Institutional Review Board of Guangdong Provincial People's Hospital(KY-Q-2022-336-03).
摘要Objective:The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis(PAS)in pediatric patients after surgical repair of complicated congenital heart diseases(CHDs).Methods:All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study.Results:A total of 41 patients(30 males,11 females;median age 5.0 years,median weight 17 kg)were followed-up for a median of 7.1 years.Follow-up echocardiography results demonstrated that the target vessel diameter increased from(3.4±1.1)mm preoperatively to(6.2±1.9)mm one year post-procedure and(6.0±1.5)mm at the final follow-up(p72 mmHg)was significantly associated with long-term adverse events(p=0.024).Conclusion:Percutaneous stent implantation for residual PAS after surgical repair of complicated CHDs effectively relieves vessel stenosis,stabilizes cardiac function,and improves long-term prognosis in pediatric patients.In-stent restenosis remains an unresolved complication,necessitating further advancements in interventional strategies.
基金supported by the Research Funding of Hangzhou International Innovation Institute of Beihang University(Grant No.015731201-2024KQ126)National Key R&D Program of China(Grant No.2023YFF0716600)National Natural Science Foundation of China(Grant No.62271021).
摘要The steel-epoxy-steel sandwich structures provide enhanced corrosion resistance and fatigue resistance,making them suitable for pipeline rehabilitation with effective repair and long-term durability.However,the repair quality can be compromised by disbond between the steel and epoxy layers,whichmay result frominsufficient epoxy injection.Conventional ultrasonic testing faces challenges in accurately locating disbond defects due to aliased echo interference at interfaces.This paper proposes a signal processing algorithm for improving the accuracy of ultrasonic reflection method for detecting disbond defects between steel and epoxy layers.First,a coati optimization algorithmvariational mode decomposition(COA-VMD)is applied to adaptively decompose the ultrasonic signals and extract the intrinsic mode function components that show high correlation with the defect-related signals.Then,by calculating the relative reflectance at the interface and establishing a quantitative evaluation index based on acoustic impedance discontinuity,the locations of disbond defects are identified.Experimental results demonstrate that this method can effectively detect the locations of disbond defects between steel and epoxy layers.
基金funded by the National Key R&D Program of China(Grant Nos.2018YFB0504900 and 2015AA123700)
摘要In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated.
基金funded by the FY3-03 project and the National Key Technology Research and Development Program of China(Grant Nos.2018YFB0504900 and 2018YFB0504905)。
摘要Fengyun-3 E(FY-3E),the world’s first early-morning-orbit meteorological satellite for civil use,was launched successfully at the Jiuquan Satellite Launch Center on 5 July 2021.The FY-3E satellite will fill the vacancy of the global early-morning-orbit satellite observation,working together with the FY-3C and FY-3D satellites to achieve the data coverage of early morning,morning,and afternoon orbits.The combination of these three satellites will provide global data coverage for numerical weather prediction(NWP)at 6-hour intervals,effectively improving the accuracy and time efficiency of global NWP,which is of great significance to perfect the global earth observing system.In this article,the background and meteorological requirements for the early-morning-orbit satellite are reviewed,and the specifications of the FY-3E satellite,as well as the characteristics of the onboard instrumentation for earth observations,are also introduced.In addition,the ground segment and the retrieved geophysical products are also presented.It is believed that the NWP communities will significantly benefit from an optimal temporal distribution of observations provided by the early morning,mid-morning,and afternoon satellite missions.Further benefits are expected in numerous applications such as the monitoring of severe weather/climate events,the development of improved sampling designs of the diurnal cycle for accurate climate data records,more efficient monitoring of air quality by thermal infrared remote sensing,and the quasicontinuous monitoring of the sun for space weather and climate.
基金the National Natural Science Foundation of China(Grant Nos.41830104,41661144007,41675022,and 41375148)Research and Development Program of China(Grant No.2017YFC1501402)the Jiangsu Provincial 2011 Program(Col-laborative Innovation Center of Climate Change).
摘要Microwave Land Surface Emissivity(MLSE)over China under both clear and cloudy sky conditions was retrieved using measurements of recalibrated microwave brightness temperatures(Tbs)from Fengyun-3B Microwave Radiation Imager(FY-3B MWRI),combined with cloud properties derived from Himawari-8 Advanced Himawari Imager(AHI)observations.The contributions from cloud particles and atmospheric gases to the upwelling Tbs at the top of atmosphere were calculated and removed in radiative transfer.The MLSEs at horizontal polarizations at 10.65,18.7,and 36.5 GHz during 7 July 2015 to 30 June 2019 over China showed high values in the southeast vegetated area and low values in the northwest barren,or sparsely vegetated,area.The maximum values were found in the belt area of the Qinling-Taihang Mountains and the eastern edge of the Qinghai-Tibet Plateau,which is highly consistent with MLSEs derived from AMSR-E.It demonstrates that the measurements of FY-3B MWRI Tbs,including its calibration and validation,are reliable,and the retrieval algorithm developed in this study works well.Seasonal variations of MLSE in China are mainly driven by the combined effects of vegetation,rainfall,and snow cover.In tropical and southern forest regions,the seasonal variation of MLSE is small due to the enhancement from vegetation and the suppression from rainfall.In the boreal area,snow causes a significant decrease of MLSE at 36.5 GHz in winter.Meanwhile,the MLSE at lower frequencies experiences less suppression.In the desert region in Xinjiang,increases of MLSEs at all frequencies are observed with increasing snow cover.
基金supported by the National Natural Science Foundation of China(32271737,32071544)the Interdisciplinary Innovation Team of the Chinese Academy of Sciences(CAS)“Light of West China”Program(xbzg-zdsys-202207)+1 种基金the Shenzhen Zhilan Foundation(2021070451A)Nature Science Foundation of Sichuan Province(2022NSFSC0125).
摘要Considering the increased anthropogenic impacts,species with a limited range and low detectability often lack fundamental information and conservation actions,placing them at a high risk of endangerment.The Chinting alpine toad Scutiger chintingensis is a rare mountain amphibian endemic to the eastern margin of the Qinghai-Xizang Plateau in China.Within its whole distribution range,only three known populations(Wolong,Emei,and Wawu)exist and no recent population status report has been documented for this species over the past two decades.From 2020 to 2023,we investigated the species distribution,and assessed the risk factors for the main populations.We recorded this species in all distribution areas,and updated a new distribution site with a lower elevation limit.The relative population density was 0.024±0.012 ind./m2on Mount Emei,whereas only 0.008±0.017 ind./m2on Mount Wawu.No significant difference was observed in the number of individuals between the two populations;however,the relative population density was significantly different.Sewage and waste discharge resulting from the construction of scenic areas,as well as disturbances from tourism,were the primary anthropogenic factors that influenced the survival of this species.Our results provide the updated information on the distribution and population status of the Chinting alpine toad,and suggest that unrecorded populations,as well as a wider elevation range,may exist for this species.Our findings emphasise the importance of timely updates of species distribution and population information and offer a basis for the future conservation of endangered amphibians.
基金Project supported by the National Natural Science Foundation of China(Grant No.11574362)
摘要Here in this paper,we report a room-temperature operating infrared photodetector based on the interband transition of an In As Sb/Ga Sb quantum well.The interband transition energy of 5-nm thick In As(0.91)Sb(0.09) embedded in the Ga Sb barrier is calculated to be 0.53 e V(2.35μm),which makes the absorption range of In As Sb cover an entire range from short-wavelength infrared to long-wavelength infrared spectrum.The fabricated photodetector exhibits a narrow response range from 2.0μm to 2.3μm with a peak around 2.1μm at 300 K.The peak responsivity is 0.4 A/W under-500-m Vapplied bias voltage,corresponding to a peak quantum efficiency of 23.8%in the case without any anti-reflection coating.At 300 K,the photodetector exhibits a dark current density of 6.05×10^-3A/cm^2 under-400-m V applied bias voltage and 3.25×10^-5A/cm^2 under zero,separately.The peak detectivity is 6.91×10^10cm·Hz^1/2/W under zero bias voltage at 300 K.
基金supported by the Foundation of Peking University for Young Scientistthe National Natural Science Foundation of China(Grant No.29874003).
摘要The first TEMPO-mediated'living'free radical polymerization of liquid crystalline monomer,2,5-bis[(4-methoxyphenyl)oxycarbonyl]styrene(MPCS),was carried out at 130 degrees C with BPO as an initiator.The molecular weight of the polymer can be varied from rather low values to high values while maintaining narrow polydispersity.It was observed that the polymerization of MPCS proceeded much faster than that of styrene.A tentative explanation for this fast polymerization was suggested.
基金Supported by the National Natural Science Foundation of China under Grant Nos U1532261 and U1630141
摘要The synergism effect of total ionizing dose(TID) on a single event transient(SET) in a bipolar comparator is investigated. Experimental results show that the shapes of the SET are considerably influenced by the TID accumulated in low dose rates. The variation tendency of SET shapes can be accurately simulated by temperature switching irradiation. The mechanism of this synergism effect is also analyzed in brief via the operating schematic of a comparator. After the accumulation of 100 krad(Si), the lower tendency of negative SET can be attributed to the degeneration of . The change tendency of a positive SET, either lower or higher, is dependent on the load condition that limits the output range of the comparator.
摘要BACKGROUND Improper methods of contraception greatly increase the risk of abortion,cervical or endometrial lesions,and the number of recurrent artificial abortions.These complications result in the deterioration of a patient’s outcome.Further,the proportion of artificial abortions is highest among unmarried females.Placement of an intrauterine device,such as the Mirena,after an artificial abortion may decrease the likelihood of an endometrial injury caused by recurrent abortions while significantly improving its contraceptive effects.AIM To discuss the effect of Mirena placement on reproductive hormone levels at different time points after an artificial abortion.METHODS Women(n=119)undergoing an artificial abortion operation were divided into the study(n=56)and control(n=63)groups.In the study group,the Mirena was inserted immediately after the artificial abortion,whereas in the control group,it was inserted 4–7 d after the onset of the first menstrual cycle after abortion.All participants were followed-up for 6 mo to observe the continuation and expulsion rates and adverse reactions and to measure the levels of serum estradiol(E2),follicle stimulating hormone(FSH),and luteinizing hormone(LH).RESULTS The continuation rates were 94.64%and 93.65%in the study group and the control group,respectively.The expulsion rates were 1.79%and 3.17%in the study group and the control group,respectively.There was no statistically significant difference between the two groups(P>0.05).There were also no statistically significant differences in the proportion of patients with bacterial vaginitis,trichomonas vaginitis,or cervicitis between the groups(P>0.05).Six months after Mirena placement,E2 Levels were 45.50±7.13 pg/mL and 42.91±8.10 pg/mL,FSH 13.60±3.24 mIU/mL and 14.54±3.11 mIU/mL,and LH 15.11±2.08 mIU/mL and 14.60±3.55 mIU/mL in the study and control groups,respectively.There were no significant differences in hormone levels between the two groups(P>0.05).There were also no statistically significant differences in the proportions of abnormal menstruation,prolonged menstruation,or pain during intercourse between the study and control groups after Mirena placement(P>0.05).There were no statistically significant differences in uterine volume,sexual desire,sexual activity,or the sexual satisfaction score between the study and control groups before and after Mirena placement(P>0.05).CONCLUSION Placement of a Mirena intrauterine device immediately after an artificial abortion does not increase the risk of adverse reactions and can help prevent endometrial injury caused by recurrent abortions.
基金This study was reviewed and approved by the Ethics Committee of Anding Hospital in Tianjin,No.2021-42.
摘要BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent obesity.AIM To investigate the relationship between sleep rhythm and obesity among adolescents and further explores the interactive effect of sleep rhythm and gender on adolescent obesity,providing a theoretical basis for developing interventions for adolescent obesity.METHODS Research data source Tianjin Mental Health Promotion Program for Students.From April to June 2022,this study selected 14201 students from 13 middle schools in a certain district of Tianjin as the research subject using the convenient cluster sampling method.Among these students,13374 accepted and completed the survey,with an effective rate of 94.2%.The demographic data and basic information of adolescents,such as height and weight,were collected through a general situation questionnaire.The sleep rhythm of adolescents was evaluated using the reduced version of the morningness-eveningness questionnaire.RESULTS A total of 13374 participants(6629 females,accounting for 49.56%;the average age is 15.21±1.433 years)were analyzed.Among them,the survey showed that 2942 adolescent were obesity,accounting for 22%and 2104 adolescent were overweight,accounting for 15.7%.Among them,1692 male adolescents are obese,with an obesity rate of 25.1%,higher than 18.9%of female adolescents.There is a statistically significant difference between the three groups(χ2=231.522,P<0.000).The obesity group has the smallest age(14.94±1.442 years),and there is a statistical difference in age among the three groups(F=69.996,P<0.000).Obesity rates are higher among individuals who are not-only-child,have residential experience within six months,have family economic poverty,and have evening-type sleep(P<0.05).Logistic regression analysis shows a correlation between sleep rhythm and adolescent obesity.Evening-type sleep rhythm can increase the risk of obesity in male adolescents[1.250(1.067-1.468)],but the effect on female obesity is not remarkable.Further logistic regression analysis in the overall population demonstrates that the interaction between evening-type sleep rhythm and the male gender poses a risk of adolescent obesity[1.122(1.043-1.208)].CONCLUSION Among adolescents,the incidence of obesity in males is higher than in females.Evening-type sleep rhythm plays an important role in male obesity but has no significant effect on female obesity.Progressive analysis suggests an interactive effect of sleep rhythm and gender on adolescent obesity,and the combination of evening-type sleep and the male gender promotes the development of adolescent obesity.In formulating precautions against adolescent obesity,obesity in male adolescents with evening-type sleep should be a critical concern.
基金Supported by Beijing University of Technology(105000546317502,105000514116002)Beijing Municipal Education Commission(KM201910005007).
摘要Graphene oxide(GO)is one typical two-dimension structured and oxygenated planar molecular material.Researchers across multiple disciplines have paid enormous attention to it due to the unique physiochemical properties.However,models used to describe the structure of GO are still in dispute and ongoing to update.And currently,synthesis methods for mass production are seemingly abundant but in fact,dominated by a few core methodologies.To update with the state-of-art opinions and progresses,herein we present a mini critical review regarding the synthesis of GO as well as its models and simulations of structure.Also,we discuss the perspectives.
基金supported by the National Key Research and Development Program(No.2022YFD2001704).
摘要Simultaneous localization and mapping(SLAM)is one of the most attractive research hotspots in the field of robotics,and it is also a prerequisite for the autonomous navigation of robots.It can significantly improve the autonomous navigation ability of mobile robots and their adaptability to different application environments and contribute to the realization of real-time obstacle avoidance and dynamic path planning.Moreover,the application of SLAM technology has expanded from industrial production,intelligent transportation,special operations and other fields to agricultural environments,such as autonomous navigation,independent weeding,three-dimen-sional(3D)mapping,and independent harvesting.This paper mainly introduces the principle,sys-tem framework,latest development and application of SLAM technology,especially in agricultural environments.Firstly,the system framework and theory of the SLAM algorithm are introduced,and the SLAM algorithm is described in detail according to different sensor types.Then,the devel-opment and application of SLAM in the agricultural environment are summarized from two aspects:environment map construction,and localization and navigation of agricultural robots.Finally,the challenges and future research directions of SLAM in the agricultural environment are discussed.
基金Supported by American Heart Association Scientist Development Grant,No.11SDG7600103
摘要AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets were subjected ex vivo to physiologic FSS,supra-physiologic FSS magnitude at normal frequency and supra-physiologic FSS frequency at normal magnitude for 48 h in a double-sided cone-and-plate bioreactor filled with standard culture medium. The role of BMP-4 and TGF-β1 in the valvular response was investigated by promoting or inhibiting the downstream action of those cytokines via culture medium supplementation with BMP-4 or the BMP antagonist noggin,and TGF-β1 or the TGF-β1 inhibitor SB-431542,respectively. Fresh porcine leaflets were used as controls. Each experimental group consisted of six leaflet samples. Immunostaining and immunoblotting were performed to assess endothelial activation in terms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressions,paracrine signaling in terms of BMP-4 and TGF-β1 expressions and extracellular matrix(ECM) remodeling in terms of cathepsin L,cathepsin S,metalloproteinases(MMP)-2 and MMP-9 expressions. Immunostained images were quantified by normalizing the intensities of positively stained regions by the number of cells in each image while immunoblots were quantified by densitometry. R E S U LT S :Regardless of the culture medium,physiologic FSS maintained valvular homeostasis. Tissue exposure to supra-physiologic FSS magnitude in standard medium stimulated paracrine signaling(TGF-β1:467% ± 22% vs 100% ± 6% in freshcontrols,BMP-4:258% ± 22% vs 100% ± 4% in fresh controls; P 0.05). Supra-physiologic FSS frequency had no effect on endothelial activation and paracrine signaling regardless of the culture medium but TGF-β1 silencing attenuated FSS-induced ECM degradation via MMP-9 downregulation(MMP-9:302% ± 182% vs 100% ± 42% in fresh controls; P > 0.05).CONCLUSION:Valvular tissue is sensitive to FSS abnormalities. The TGF-β1 inhibitor SB-431542 is a potential candidate molecule for attenuating the effects of FSS abnormalities on valvular remodeling.
基金Funding for this project is provided by USDA NIFA to Project No.2017-68007-26318through the Agriculture and Food Research Initiative,Water for Agricultural Challenge Area,and hatch project TEX07726.
摘要Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids DALZ 1701,DALZ 1713,and'Innovation',and two Z.minima×Z.matrella hybrids(DALZ 1309 and'Lazer').Treatments included a control(nutrient solution)and two saline treatments representing moderate and high salt levels.The electrical conductivity(EC)was 1.3 dS m−1 for control and moderate(EC5)and high salinity(EC10)were 5.0 and 10.0 dS m−1,respectively.At the end of eight-weeks of treatment,the relative(percent control)shoot dry weight(DW)was greatest in'Diamond'in EC10,and the relative root DW was greatest in DALZ 1309 in EC5.A cluster analysis based on the relative tissue dry weight identified'Diamond',DALZ 1309,and DALZ 1713 as the most salt tolerant genotypes.Additionally,the green leaf area(GLA)index of'Diamond'and DALZ 1713 were 98.8%and 100%,respectively,indicating excellent visual appearance under high salt levels.Bi-weekly clipping DW showed that'Diamond'continued to produce biomass throughout the duration of the study under the EC10 treatment.Sodium(Na+)and chloride(Cl−)content in the shoot tissue of the seven turfgrass genotypes indicated that lower concentrations corresponded to greater salt tolerance indicating exclusion of Na+and Cl−from the shoot tissue.Taken together,the genotypes'Diamond'and DALZ 1713 were determined to be the most salt tolerant and recommended for use in areas with high soil or water salinity.
基金supported by the National Natural Science Foundation of China (32271737, 32071544)the Interdisciplinary Innovation Team of the Chinese Academy of Sciences (CAS) “Light of West China” Program (xbzg-zdsys-202207)+1 种基金the Shenzhen Zhilan Foundation (2023010291A)Nature Science Foundation of Sichuan Province (24NSFSC2934)。
摘要For oviparous species with little or no parental care, oviposition site choice may be a powerful agent of natural selection, playing an important role in the evolution of species fitness and life history. Identifying and clarifying the microhabitat characteristics of oviposition sites are key to understanding life history strategies and local adaptations for amphibians with complex biphasic life cycles. However, oviposition strategies for amphibians in alpine streams remain poorly understood. Here, we focused on oviposition site selection for the Chinting alpine toad(Scutiger chintingensis) on Mount Wawu on the eastern margin of the Qinghai-Xizang Plateau. We identified the microhabitat differences between oviposition sites and non-oviposition sites for this species, predicted oviposition site selection patterns,and evaluated the relative importance of each microhabitat variable as well as the effects of the variables on the model prediction probabilities. This study revealed that the microhabitat characteristics of oviposition sites in this species included high water velocity, shallow water, and high-water surface coverage. Water velocity and rock volume were the most important variables explaining the categories of oviposition sites. Additionally, we observed nearly half the proportion of overlapping oviposition in this species, and the benefits of this behavior in terms of microhabitat characteristics need to be explored in the future. Our study revealed an oviposition site selection strategy for amphibians within alpine streams, and contributed to understanding the life history and environmental adaptation strategies of an endemic alpine stream species, and thereby providing guidance for effective conservation strategies for alpine stream amphibians under global change.