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Achieving excellent strength-ductility-superelasticity combination in high-porosity NiTiNb scaffolds via high-temperature annealing 认领 引用 被引量：2
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作者 Wei Liu Yintao Zhang +7 位作者 Binghao Wang Shifeng Liu Yan Wang Ling Zhang Liang Zhang Lai-Chang Zhang Weijie Lu Liqiang Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第3期221-233,共13页
Metallic scaffolds with lightweight,low elastic modulus,and high energy-absorbing capacity are widely utilized in industrial applications but usually require post-heat treatment to enhance their comprehen-sive mechani... Metallic scaffolds with lightweight,low elastic modulus,and high energy-absorbing capacity are widely utilized in industrial applications but usually require post-heat treatment to enhance their comprehen-sive mechanical properties.However,it is unclear how to utilize the impact ofβ-Nb on the surrounding matrix for NiTiNb ternary alloys to achieve strength-ductility-superelasticity enhancement.Here,we pre-pared rhomboidal dodecahedral NiTiNb porous scaffolds with a porosity of 85.9%by additive manufac-turing.Subsequently,annealing treatment was employed to drastically reduce the phase transformation temperatures and expand the thermal hysteresis.Interestingly,the 850℃ annealed scaffold exhibited exceeding double compressive strength of the as-built sample,with a remarkable improvement in ductil-ity and superelasticity.From the microstructure perspective,high-temperature annealing caused a further eutectic reaction of the unmelted Nb particles with the NiTi matrix and the transformation of mesh-likeβ-Nb into dispersedly distributed sphericalβ-Nb particles.The microstructure evolution after defor-mation indicated that stress-induced martensitic transformation occurred in the matrix away from the NiTi-Nb eutectic region whereas almost no martensite formed nearbyβ-Nb particles.Atom probe tomog-raphy characterization revealed an element diffusion zone in several nanometers surrounding theβ-Nb particle,where the substitution of Nb with Ti led to a higher Ni:Ti atomic ratio,lowering transforma-tion temperatures.Molecular dynamics simulations illustrated thatβ-Nb particles can not only entangle dislocations internally,acting as reinforcements but also hinder the twin growth,contributing to strain hardening.This work elucidates the influence ofβ-Nb particles on the deformation mechanism of the NiTi-Nb eutectic region through in-depth atomic-scale investigation,which can provide inspiration for the improvement of comprehensive mechanical properties of NiTiNb alloys. 展开更多
关键词 NiTiNb Eutectic alloys Mechanical properties Metallic scaffolds Strain hardening
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Maternal high-fat diet impairs offspring glucose metabolism and programs hepatic DNA methylation linked to NK cell-mediated cytotoxicity signaling pathway at weaning 认领 引用
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作者 Sheng Zheng Ling Zhang +3 位作者 Shixuan Zhang Guanyu Hu Yikai Li Jia Zheng 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1576-1587,共12页
Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,pa... Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,particularly during the early stages of offspring development,remain poorly understood.In this study,female C57BL/6J mice were randomly assigned to either a high-fat diet or normal chow diet throughout gestation and lactation.Methylated DNA immunoprecipitation(MeDIP)coupled with microarray analysis was employed to identify differentially methylated genes in the livers of offspring at weaning age.We found that maternal high-fat diet feeding predisposes offspring to obesity and impaired glucose metabolism as early as the weaning period.DNA methylation profile analysis unveiled a significant enrichment of differentially methylated genes within the natural killer(NK)cell-mediated cytotoxicity pathway.MeDIP-PCR validated reduced methylation levels of specific genes within this pathway,including tumour necrosis factorα(TNF-α),phosphoinositide 3-kinase(PI3K),and SHC adaptor protein 1(SHC1).Consistently,the expressions of TNF-α,PI3K,and SHC1 were significantly upregulated,accompanied by elevated serum TNF-αand interleukin-6(IL-6)levels in offspring from dams fed with high-fat diet.Moreover,we assessed the expressions of genes associated with NK cell activities,uncovering a notable rise in hepatic granzyme B levels and a trend towards increased CD107a expression in offspring from dams fed a high-fat diet.In addition,methylation levels of TNF-α,PI3K,and SHC1 promoters were inversely correlated with glucose response during glucose tolerance testing.In conclusion,our findings underscore the critical role of the NK cell-mediated cytotoxicity signaling pathway in mediating DNA methylation patterns,thereby contributing to the programming effects of maternal high-fat diet consumption on offspring glucose metabolism as early as the weaning period. 展开更多
关键词 Maternal high-fat diet consumption Glucose metabolism DNA methylation Natural killer cell-mediated cytotoxicity Weaning
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A nonlinear unified hardening model for breakable siliceous mudstone coarse-grained soil under low confining pressure considering penetrating erosion 认领 引用
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作者 Ling Zhang Yunhao Chen +3 位作者 Xuzhen He Shaoheng Dai Biao Luo Daichao Sheng 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第5期3916-3933,共18页
The stress-strain behavior of brittle siliceous mudstone coarse-grained soils(SMCGSs)under penetrating erosion critically affects the stability of SMCGS-filled embankments in erosion-prone areas,yet remains insufficie... The stress-strain behavior of brittle siliceous mudstone coarse-grained soils(SMCGSs)under penetrating erosion critically affects the stability of SMCGS-filled embankments in erosion-prone areas,yet remains insufficiently understood,particularly regarding particle crushing and critical state behavior under low confining pressures.This study proposes a modified constitutive model to characterize erosion-induced mechanical degradation and nonlinear critical state evolution.A normalized parameter ϑ,derived from the principle of crushing equivalence,is introduced to capture the coupled effects of particle breakage and critical state shifts under varying erosion intensities.Along with a nonlinear tuning index δ,this parameter is integrated into the unified hardening model for low confining pressure(UH-L),resulting in the N-UH-LE model.Consolidated drained(CD)triaxial tests under confining pressures of 100-400 kPa are conducted for model calibration and validation.The model predictions exhibit strong agreement with experimental results,with a maximum relative error of 7.76%.The N-UH-LE model successfully reproduces key mechanical responses,including hardening,softening,shear dilation,and volumetric changes across different erosion levels.Furthermore,erosion-induced degradation decreases with lower confining pressures and higher initial void ratios(e0=0.3,0.5,and 0.7),while variations in interlocking strength(τ0cotφ=40 kPa,80 kPa,and 120 kPa)show limited influence. 展开更多
关键词 Penetrating erosion Particle breakage Critical state Breakable coarse-grained soil(SMCGS) Unified hardening constitutive(UH)
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High-throughput computational screening of functionalized MOFs for energy-efficient CO2capture:Balancing selective CO2adsorption performance and energy inputs 认领 引用
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作者 Sen Liu Zhe Sun +8 位作者 Bo Liao Huili Zhang Ling Zhang Yuchen Huang Lin Wan Maohuai Wang Shuxian Wei Baojun Wei Xiaoqing Lu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第3期136-145,共10页
The rational design of high-performance CO2adsorbents remains a critical challenge in addressing global carbon emissions,with metal-organic frameworks(MOFs)emerging as promising candidates due to their tunable pore... The rational design of high-performance CO2adsorbents remains a critical challenge in addressing global carbon emissions,with metal-organic frameworks(MOFs)emerging as promising candidates due to their tunable pore environments.However,the lack of systematic guidelines for functional group selection has hindered their practical implementation in carbon capture applications.Here,this gap was addressed by developing a comprehensive design framework through high-throughput computational screening.Through construction of a topology-directed database of 4797,integrating 10 metal centers with 144 functionalized ligands(18 ligands modified by–NH2,–NO2,–CH3,–CF3,–SH2,–SO2,–OH,and–OLi)across 36 topologies,the fundamental structure–property relationships governing CO2capture performance was established.Multi-metric evaluation reveals that–NO2,–SO2,and–OLi dramatically enhance CO2selectivity over CH_4/N2via selectivity(Sads),working capacity(ΔN),adsorbent performance score(APS),sorbent selection parameter(Ssp),and renewability R.Specially,ΔN rises from 2.34(pristine)to 5.91–7.94 mmol g-1and Sadssurges from 24.94/40.36 to 121.11/176.87(–NO2),149.94/215.54(–SO2),and 58.64/267.44(–OLi).Besides,the critical trade-off between adsorption strength and renewability demonstrates that enhanced performance comes at the cost of reduced renewability,where stronger CO2affinity(isosteric heat of-29.15,-29.96,and-30.09 for–NO2,–SO2,and–OLi)compromises renewability(R reduced by -50%).To resolve this trade-off,a novel energy efficiency(η)metric was introduced,which holistically evaluates both adsorption performance(Sads,ΔN,APS,Ssp,and R)and energy inputs(desorption heat,pressure-swing energy,net loss).This leads to the identification of–SO2as the optimal functional group that balances exceptional CO2capture(η=6.17/12.78 for CO2over CH_4/N2),surpassing the second higher of 4.74/8.80 in–CF3and 0.99/2.18 in non-functionalized counterparts.Adopting high-throughput computational screening methods,this work provides both fundamental insights into host–guest interactions in functionalized MOFs and a practical framework for designing next-generation adsorbents,bridging the gap between materials discovery and process engineering considerations in carbon capture technologies. 展开更多
关键词 Metal-organic frameworks High-throughput computational screening Selective CO2adsorption Functional group engineering Energy efficiency
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Manufacturing novel Fe-based nanocrystalline powders with high saturation magnetization and low core loss by gas atomization 认领 引用
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作者 Yanqiu Li Ling Zhang +4 位作者 Xingjie Jia Yaqiang Dong Aina He Jiawei Li Baogen Shen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2026年第1期182-189,共8页
Fe-based nanocrystalline powders are ideal soft magnetic materials for matching the wide bandgap semiconductors.Previously developed Fe-based nanocrystalline alloys are difficult to produce high-quality precursor powd... Fe-based nanocrystalline powders are ideal soft magnetic materials for matching the wide bandgap semiconductors.Previously developed Fe-based nanocrystalline alloys are difficult to produce high-quality precursor powder by gas atomization due to their poor amorphous forming ability,and their following nanocrystallizations also require high temperatures or heating rates.In present work,we invented novel high-performance Fe-based nanocrystalline powders that can be directly manufactured by gas atomization without annealing.The as-atomized Fe73.3Si12B13Cu1.7nanocrystalline powders exhibit fine α-Fe(Si)crystals with an average size of 15.1 nm and high saturation magnetization(Ms)of 156.2 emu/g.The Fe73.3Si12B13Cu1.7soft magnetic powder cores annealed at 480℃for 60 min process high effective permeability of 35.9 and low core losses(50 mT/100 kHz)of 310.1 mW/cm3.These outstanding magnetic properties and good processability make the developed Fe73.3Si12B13Cu1.7nanocrystalline powders highly promising for high-performance inductors and transformers. 展开更多
关键词 Fe-based nanocrystalline alloys High Cu content Gas atomization Saturation magnetization Core loss
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Chronic methanol exposure induces cognitive impairment and Alzheimer ' s- like pathology in rhesus monkeys 认领 引用
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作者 Hongwei Li Changhua Shi +7 位作者 Keya Li Xinjing Fu Ying Lyu Yanfeng Xu Yunlin Han Wei Liang Qin Chuan Ling Zhang 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第2期264-279,共16页
Background:The absence of effective animal models for sporadic Alzheimer's disease(AD)remains a pivotal barrier to therapy development.Because methanol metabolism produces endogenous formaldehyde,a neurotoxic agen... Background:The absence of effective animal models for sporadic Alzheimer's disease(AD)remains a pivotal barrier to therapy development.Because methanol metabolism produces endogenous formaldehyde,a neurotoxic agent linked to cognitive decline,this study investigated whether chronic,low-dose methanol exposure could recapitulate AD-like pathology and cognitive deficits in rhesus monkey,thereby establishing a nonhuman primate animal model driven by this environmental-metabolic insult.Methods:Adult rhesus monkeys received low-concentration methanol for 9 months.Behavioral tests for cognition,locomotion,sleep,and vision were conducted.Postmortem analyses involved histopathological examination,immunohistochemistry,immunofluorescence,and Western blot to evaluate neuronal integrity,microglial activation,and the expression of key proteins associated with AD(amyloid-β[Aβ],phosphorylated tau,TAR DNA-binding protein 43[TDP-43])and cellular stress(synaptic markers,mitochondrial fission,autophagy,and apoptosis-related proteins).Results:Chronic methanol exposure led to progressive cognitive and memory impairment without significant motor or visual deficits.Neuropathology revealed brain atrophy,neuronal loss,synaptic damage,microglial activation,and mitochondrial structural disorganization.Critically,the exposed animals exhibited hallmark AD-like molecular alterations,including increased Aβ deposition,tau hyperphosphorylation,and TDP-43 dysregulation.Furthermore,neurotoxicity was associated with elevated urinary formaldehyde,enhanced mitochondrial fission,increased autophagy,and elevated apoptosis.Conclusion:Chronic low-dose methanol exposure in rhesus monkeys recapitulates progressive cognitive deficits and AD-like neuropathological features.This model,driven by endogenous formaldehyde toxicity,effectively mimics key aspects of sporadic AD.Our findings shed light on the neurotoxic mechanisms of methanol and propose a reproducible and translationally relevant nonhuman primate model for studying AD pathogenesis and evaluating potential therapeutics. 展开更多
关键词 Alzheimer's disease(AD) amyloid-β(Aβ) animal model cognitive impairment methanol
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A colorimetric biosensor for Escherichia coli detection in food based on aptamer-enhanced oxidase-mimicking activity of octahedral Ag2O nanoparticles 认领 引用
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作者 Xiaohuan Huang Ling Zhang +6 位作者 Tingshu Lu Jie Li Mian Wang Wei Dai Chengyin Zhou Jia Xu Yuangen Wu 《Food Innovation and Advances》 2026年第2期185-194,共10页
Escherichia coli(E.coli)poses a grave threat to food safety,underscoring the need for expeditious and precise detection methodologies.Conventional colorimetric approaches are simple,but they frequently lack accuracy a... Escherichia coli(E.coli)poses a grave threat to food safety,underscoring the need for expeditious and precise detection methodologies.Conventional colorimetric approaches are simple,but they frequently lack accuracy and stability.This study constructed an aptamer-based colorimetric biosensor,leveraging the enzyme-mimicking activity of octahedral Ag2O nanoparticles(NPs),mediated by oligonucleotides,aiming for highly sensitive foodborne E.coli detection.The P12-55 aptamer can be adsorbed onto the octahedral Ag2O NPs surface,thereby significantly enhancing their oxidase-mimicking activity.The aptamer enhances activity by promoting·O2−generation,and accelerating electron transfer to the 3,3',5,5'-tetramethylbenzidine(TMB)substrate.In the presence of E.coli in the sensing system,the aptamer exhibits a preferential binding affinity for the bacteria,thereby restoring the oxidase-mimicking activity and enabling the transduction of the detection signal.The biosensor exhibited a range of linear detection of 3×102-3×108CFU·mL−1,and the limit of detection(LOD)was as low as 4 CFU·mL−1.Recovery rates of 99.1%to 104%were achieved in milk and tap water samples,demonstrating outstanding practicality and reliability.This study proposes a novel and efficient method for the rapid detection of harmful bacteria in food,which is of significant importance for food safety assurance. 展开更多
关键词 detection methodologiesconventional Escherichia coli detection colorimetric approaches octahedral Ag O nanoparticles colorimetric biosensorleveraging oxidase mimicking activity colorimetric biosensor food safety
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Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease 认领 引用 被引量：10
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作者 Zhiqi Song Yajin Qu +8 位作者 Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin 《Animal Models and Experimental Medicine》 CAS CSCD 2021年第3期233-242,共10页
Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is ... Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.Methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications. 展开更多
关键词 5XFAD mouse model Alzheimer's disease biomarkers microarray miRNA urinary exosome
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Investigation of working pressure on the surface roughness controlling technology of glow discharge polymer films based on the diagnosed plasma 认领 引用 被引量：9
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作者 Ling ZHANG Guo CHEN +5 位作者 Zhibing HE Xing AI Jinglin HUANG Lei LIU Yongjian TANG Xiaoshan HE 《Plasma Science and Technology》 SCIE EI CAS CSCD 2017年第7期110-117,共8页
The effects of working pressure on the component, surface morphology, surface roughness, and deposition rate of glow discharge polymer （GDP） films by a trans-2-butene/hydrogen gas mixture were investigated based on ... The effects of working pressure on the component, surface morphology, surface roughness, and deposition rate of glow discharge polymer （GDP） films by a trans-2-butene/hydrogen gas mixture were investigated based on plasma characteristics diagnosis. The composition and ion energy distributions of a multi-carbon （CaHs/H2） plasma mixture at different working pressures were diagnosed by an energy-resolved mass spectrometer （MS） during the GDP film deposition process. The Fourier transform infrared spectroscopy （FT-IR）, field emission scanning electron microscope （SEM） and white-fight interferometer （WLI） results were obtained to investigate the structure, morphology and roughness characterization of the deposited films, respectively. It was found that the degree of ionization of the C4H8/H2 plasma reduces with an increase in the working pressure. At a low working pressure, the C-H fragments exhibited small-mass and high ion energy in plasma. In this case, the film had a low CH3/CH2 ratio, and displayed a smooth surface without any holes, cracks or asperities. While the working pressure increased to 15 Pa, the largest number of large-mass fragments led to the deposition rate reaching a maximum of 2.11 #m h-1, and to hole defects on the film surface. However, continuing to increase the working pressure, the film surface became smooth again, and the interface between clusters became inconspicuous without etching pits. 展开更多
关键词 glow discharge polymer films plasma diagnosis working pressure surfacemorphology surface roughness
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Rainfall Microphysical Properties of Landfalling Typhoon Yagi(201814)Based on the Observations of Micro Rain Radar and Cloud Radar in Shandong,China 认领 引用 被引量：9
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作者 Hong WANG Wenqing WANG +4 位作者 Jun WANG Dianli GONG Dianguo ZHANG Ling ZHANG Qiuchen ZHANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第6期994-1011,共18页
The development and evolution of precipitation microphysical parameters and the vertical structure characteristics associated with Typhoon Yagi(201814)are analyzed in the city of Jinan,Shandong Province based primaril... The development and evolution of precipitation microphysical parameters and the vertical structure characteristics associated with Typhoon Yagi(201814)are analyzed in the city of Jinan,Shandong Province based primarily on the observations of a micro rain radar(MRR),a cloud radar,and a disdrometer.The precipitation process is further subdivided into four types:convective,stratiform,mixed,and light precipitation according to the ground disdrometer data,which is in agreement with the vertical profile of the radar reflectivity detected by the MRR.Vertical winds may be the main source of MRR retrieval error during convective precipitation.Convective precipitation has the shortest duration but makes the largest contribution to the cumulative precipitation.Collision-coalescence is the main microphysical process of stratiform precipitation and light precipitation below the bright band observed by the MRR.It is worth noting that as Typhoon Yagi(201814)transformed into an extratropical cyclone,its raindrop size distributions no longer had the characteristics of maritime precipitation,but become more typical of the characteristic of continental precipitation,which represents a very different raindrop size distribution from that which is normally observed in a landfalling typhoon. 展开更多
关键词 typhoon rain drop size distribution micro rain radar cloud radar
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CFD modelling and optimization of oxygen supply mode in KIVCET smelting process 认领 引用 被引量：4
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作者 Jia-dong LI Ping ZHOU +3 位作者 Zhou LIAO Li-yuan CHAI Chenn Q. ZHOU Ling ZHANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2019年第7期1560-1568,共9页
The influence of oxygen supply mode on the KIVCET (a Russian acronym for flash?cyclone?oxygen?electric?smelting) process was investigated using numerical simulation. The mass rate ratio (MRR) of central oxygen to late... The influence of oxygen supply mode on the KIVCET (a Russian acronym for flash?cyclone?oxygen?electric?smelting) process was investigated using numerical simulation. The mass rate ratio (MRR) of central oxygen to lateral oxygen of the central jet distributor (CJD) burner was defined to express the oxygen supply mode, and the KIVCET process with an MRR ranging from 0.09 to 0.39 was simulated. The results show that there are four efficient reaction regions that correspond to four CJD burners. A higher central oxygen flow improves the mixing between particles and oxygen, thus enhancing reactions and shortening the reaction regions. However, a higher dust rate is induced due to the spread of the particle columns. The optimal MRR for a KIVCET furnace with a smelting capacity of 50000 kg/h is suggested to be 0.31. In this case, the chemical reactions associated with the feed are completed with an acceptable dust rate. 展开更多
关键词 KIVCET furnace central jet distributor (CJD) burner computational fluid dynamics (CFD) central oxygen lateral oxygen optimization
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Gas-hydrate formation,agglomeration and inhibition in oil-based drilling fluids for deep-water drilling 认领 引用 被引量：9
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作者 Fulong Ning Ling Zhang +2 位作者 YunzhongTu Guosheng Jiang Maoyong Shi 《Journal of Natural Gas Chemistry》 2010年第3期234-240,共7页
One of the main challenges in deep-water drilling is gas-hydrate plugs,which make the drilling unsafe.Some oil-based drilling fluids（OBDF） that would be used for deep-water drilling in the South China Sea were teste... One of the main challenges in deep-water drilling is gas-hydrate plugs,which make the drilling unsafe.Some oil-based drilling fluids（OBDF） that would be used for deep-water drilling in the South China Sea were tested to investigate the characteristics of gas-hydrate formation,agglomeration and inhibition by an experimental system under the temperature of 4 ？C and pressure of 20 MPa,which would be similar to the case of 2000 m water depth.The results validate the hydrate shell formation model and show that the water cut can greatly influence hydrate formation and agglomeration behaviors in the OBDF.The oleophobic effect enhanced by hydrate shell formation which weakens or destroys the interfacial films effect and the hydrophilic effect are the dominant agglomeration mechanism of hydrate particles.The formation of gas hydrates in OBDF is easier and quicker than in water-based drilling fluids in deep-water conditions of low temperature and high pressure because the former is a W/O dispersive emulsion which means much more gas-water interfaces and nucleation sites than the later.Higher ethylene glycol concentrations can inhibit the formation of gas hydrates and to some extent also act as an anti-agglomerant to inhibit hydrates agglomeration in the OBDF. 展开更多
关键词 oil-based drilling fluids gas hydrates water cut formation and agglomeration inhibitor
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CFD modeling of gas−liquid flow phenomenon in lead smelting oxygen-enriched side-blown furnace 认领 引用 被引量：2
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作者 Zhen-yu ZHU Ping ZHOU +3 位作者 Xing-bang WAN Zhuo CHEN Ling ZHANG Shi-bo KUANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第8期2671-2685,共15页
A validated numerical model was established to simulate gas−liquid flow behaviors in the oxygen-enriched side-blown bath furnace.This model included the slip velocity between phases and the gas thermal expansion effec... A validated numerical model was established to simulate gas−liquid flow behaviors in the oxygen-enriched side-blown bath furnace.This model included the slip velocity between phases and the gas thermal expansion effect.Its modeling results were verified with theoretical correlations and experiments,and the nozzle-eroded states in practice were also involved in the analysis.Through comparison,it is confirmed that the thermal expansion effect influences the flow pattern significantly,which may lead to the backward motion of airflow and create a potential risk to production safety.Consequently,the influences of air injection velocity and furnace width on airflow behavior were investigated to provide operating and design guidance.It is found that the thin layer melt,which avoids high-rate oxygen airflow eroding nozzles,shrinks as the injection velocity increases,but safety can be guaranteed when the velocity ranges from 175 to 275 m/s.Moreover,the isoline patterns and heights of thin layers change slightly when the furnace width increases from 2.2 to 2.8 m,indicating that the furnace width shows a limited influence on production safety. 展开更多
关键词 multiphase flow horizontal gas injection backward motion of airflow gas thermal expansion side-blown furnace lead smelting
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Electron transfer-mediated synchronization of N,N-dimethylformamide catabolism and nitrate reduction driven by zero-valent iron 认领 引用
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作者 Jing Wang Yong Tu +5 位作者 Xuwang Wu Ling Pan Dan Chen Xinbai Jiang Ling Zhang Jinyou Shen 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第2期233-248,共16页
The co-occurrence of N,N-dimethylformamide(DMF)and residual nitrogen in industrial wastewater presents significant challenges for conventional biological treatment.To overcome these limitations,this study developed an... The co-occurrence of N,N-dimethylformamide(DMF)and residual nitrogen in industrial wastewater presents significant challenges for conventional biological treatment.To overcome these limitations,this study developed an innovative zero-valent iron(ZVI)enhanced nitrate-reducing bioreactor(ZVI-NR)that establishes an efficient electron transfer pathway for simultaneous DMF mineralization and nitrate removal.The ZVI-NR system achieved complete DMF removal(100%)and high nitrate reduction efficiency(96.17%±1.50%),representing 40.37%±2.30%and 34.23%±1.30%improvements over conventional NR system.The key innovation involves establishing an Fe2+/Fe3+electron shuttle system,coupled with the selective enrichment of iron-cycling genera(such as Dojkabacteria and Denitratisoma).These genera maintain iron bioavailability and facilitate extracellular electron transfer.The increased enzymatic activity(136.96%–161.23%for nitrateitrite reductases),and dynamic extracellular polymeric substance(EPS)secretion(154.73±4.65 mg/g VSS)featuringα-helix-dominated protein structures that improve microbial aggregation(Dojkabacteria,Chryseobacterium and Arenimonas,etc.).The superior performance of the system is further attributed to dual metabolic regulation through feoAB-mediated Fe2+transport and a formate dehydrogenase mediated mechanism that is hypothesized to contribute to the proton motive force.This study demonstrates a technological breakthrough in industrial wastewater treatment,which achieves stable and complete DMF mineralization at high loading rates.The unique iron-mediated electron transfer that enhances efficient DMF degradation and optimized nitrogen removal,addressing the challenge of treating refractory wastewater containing high organic and nitrogen loads. 展开更多
关键词 N N-dimethylformamide Mineralization Iron-cycling Electron transfer Functional genes Metabolic mechanism
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SsBMR1 as a putative ABC transporter is required for pathogenesis by promoting antioxidant export and antifungal resistance in Sclerotinia sclerotiorum 认领 引用
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作者 Yijuan Ding Yaru Chai +5 位作者 Sen Li Zhaohui Wu Minghong Zou Ling Zhang Rana Kusum Wei Qian 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期166-179,共14页
The plant pathogenic fungus Sclerotinia sclerotiorum is the causative agent of Sclerotinia stem rot(SSR)disease in most dicotyledons.Among the various proteins involved in drug efflux or substance transport,ATP-bindin... The plant pathogenic fungus Sclerotinia sclerotiorum is the causative agent of Sclerotinia stem rot(SSR)disease in most dicotyledons.Among the various proteins involved in drug efflux or substance transport,ATP-binding cassette(ABC)transporters constitute a superfamily of membrane-bound proteins that may play a crucial role in the survival of S.sclerotiorum.However,the expression patterns and functions of ABC transporter genes in S.sclerotiorum remain largely uncharacterized.This study characterized a highly expressed S.sclerotiorum ABC transporter gene during inoculation on host plants,Ss BMR1.Silencing Ss BMR1 resulted in a significant reduction in hyphal growth,infection cushion development,sclerotia formation,and virulence.Moreover,host-induced gene silencing(HIGS)of Ss BMR1 significantly enhanced plant resistance.Transcriptome and metabolomics analyses suggested that Ss BMR1 is involved in antioxidant and toxin transport,thereby influencing fungal defense and cell rescue mechanisms.In comparison to the wild-type strain,Ss BMR1 gene-silenced transformants exhibited a diminished response to extracellar oxidative stress and a decreased exporting of antioxidant glutathione.Tolerance assays further demonstrated the crucial role of Ss BMR1 in conferring resistance to the plant antifungal substances,camalexin and brassinin,as well as certain fungicides.Furthermore,Ss BMR1 gene-silenced transformants showed enhanced repression on virulence when sprayed with camalexin and brassinin on the leaves.Thus,Ss BMR1 likely contributes to virulence by facilitating the export of antioxidant and providing resistance against antifungal agents.The findings of this study provide valuable insights that could contribute to the development of novel management techniques for SSR. 展开更多
关键词 ABC transporter antifungal resistance glutathione pathogenesis Sclerotinia sclerotiorum
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Modeling of microstructural evolution during dynamic recrystallization in coarse Nb microalloyed austenite 认领 引用 被引量：7
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作者 Ling Zhang Wangyue Yang Zuqing Sun 《Journal of University of Science and Technology Beijing》 2007年第2期130-135,共6页
The aim of the current study was to investigate the microstructural evolution during dynamic recrystallization in coarse Nb microalloyed austenite in thin slab direct rolling （TSDR） processing. A model was developed... The aim of the current study was to investigate the microstructural evolution during dynamic recrystallization in coarse Nb microalloyed austenite in thin slab direct rolling （TSDR） processing. A model was developed to predict the change of the austenite grain size during the dynamic recrystallization, by using the law of mixtures. The equations initially developed for partial static recrystallization were used for partial dynamic recrystallization, by adjusting the value of the constant. The results show that the change of the austenite grain size can be reasonably described by using the equations developed according to the law of mixtures. 展开更多
关键词 austenite grain size TSDR partial recrystallization dynamic recrystallization
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Effect on the Performance of Drilling Fluids at Downhole Rock Surfaces at Low Temperatures 认领 引用 被引量：1
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作者 Mingming Zheng Guosheng Jiang +3 位作者 Tianle Liu Fulong Ning Ling Zhang V.F.Chikhotkin 《Journal of Earth Science》 SCIE EI CAS CSCD 2016年第5期856-863,共8页
To maintain gas hydrate stability, low-temperature drilling fluids and high drilling speeds should be used while drilling in gas hydrate-bearing sediments. The effect of the drilling fluid on downhole rock surfaces at... To maintain gas hydrate stability, low-temperature drilling fluids and high drilling speeds should be used while drilling in gas hydrate-bearing sediments. The effect of the drilling fluid on downhole rock surfaces at low temperatures is very important to increase the drilling rate. This paper analyzed the action mechanism of the drilling fluid on downhole rock surfaces and established a corresponding evaluation method. The softening effect of six simulated drilling fluids with 0.1 wt.% of four common surfactants and two common organic salts on the downhole rock surface strength was evaluated experimentally using the established method at low temperature. The experimental results showed that the surfactants and organic salts used in the drilling fluids aided in the reduction of the strength of the downhole rock surface, and the established evaluation method was able to quantitatively reveal the difference in the softening effect of the different drilling fluids through comparison with water. In particular, the most common surfactant that is used in drilling fluids, sodium dodecyl sulfate（SDS）, had a very good softening effect while drilling under low-temperature conditions, which can be widely applied during drilling in low-temperature formations, such as natural gas hydrate-bearing sediments, the deep seafloor and permafrost. 展开更多
关键词 gas hydrate bearing sediments low temperature drilling fluid performances downholerock surface strength influence mechanism.
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Porcine kidney xenotransplantation:From primate models to clinical reality 认领 引用
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作者 Zihang Guo Ling Zhang +1 位作者 Shoulong Deng Chuan Qin 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第6期1142-1166,I0001,共25页
The escalating global incidence of end-stage renal disease has exacerbated the critical shortage of kidneys from human donors.Porcine kidney xenotransplantation has emerged as the most promising alternative solution t... The escalating global incidence of end-stage renal disease has exacerbated the critical shortage of kidneys from human donors.Porcine kidney xenotransplantation has emerged as the most promising alternative solution to providing an unlimited organ supply.In this review,we examine the historical evolution,current breakthroughs and future directions of kidney xenotransplantation.We probe the milestones from early attempts and non-human primate(NHP)experiments to recent clinical trials involving both brain-dead and living human recipients.The core of this review provides an in-depth discussion of the significant barriers in kidney xenotransplantation,including immune rejection,physiological incompatibilities and the risk of cross-species infection.Next,we systematically outline the multifaceted strategies developed to overcome these barriers.The rapid development of gene editing technology has enabled the establishment of multigene-edited pigs.These donors feature knockout of key carbohydrate antigen genes and expression of various human proteins,including complement regulators,anticoagulants,and immunomodulators.These genetic modifications have extended xenograft survival in NHP models to over 750 days.This is synergized with novel immunosuppressive regimens,tolerance-induction protocols,cellular therapies,and emerging adjuncts like bioengineering materials and organoidon-a-chip technologies.Finally,we discuss future directions,raising concerns about potential complications arising from the biomechanical incompatibility between pigs and human in xenotransplantation,highlighting the need to deploy advanced multiomics to identify unknown xenoantigens,optimize bioengineering materials for local immunomodulation,and validate extracellular vesicles as non-invasive biomarkers.While challenges for long-term xenograft survival remain,kidney xenotransplantation is rapidly advancing from preclinical research to clinical reality,holding huge potential to resolve the organ shortage crisis. 展开更多
关键词 genetically engineered pigs immune rejection immunosuppression kidney xenotransplantation
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The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis 认领 引用 被引量：1
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作者 Yong-Hong Man Isabella Warmbrunn +1 位作者 Ling Zhang Zhi-Bing Zhang 《Asian Journal of Andrology》 SCIE CAS CSCD 2022年第3期238-242,共5页
Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cyto... Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport(IFT)particles,where the inner counterparts undergo reverse trafficking.The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction.Much progress has been made on the mechanisms and functions of IFT;however,recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis.In this review,we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility. 展开更多
关键词 IFT25 cilium hedgehog signaling intraflagellar transport spermatogenesis
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Hub genes and diagnostic model associated with mitochondrial function in Alzheimer ' s disease 认领 引用
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作者 Xuchao Zhu Ling Zhang Chuan Qin 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第2期237-248,I0001,共12页
Background:Alzheimer's disease(AD)represents the most prevalent neurodegenerative disorder,with mitochondrial dysfunction being observed in both AD patients and mouse models.Nonetheless,further investigation is re... Background:Alzheimer's disease(AD)represents the most prevalent neurodegenerative disorder,with mitochondrial dysfunction being observed in both AD patients and mouse models.Nonetheless,further investigation is required to elucidate the pathogenic genes associated with AD and to develop early diagnostic methodologies centered on mitochondrial function.Methods:In this study,the dataset GSE132903 was retrieved from the GEO database,encompassing both non-demented(ND)control and AD samples.Through the combination of differential expression gene analysis,weighted gene co-expression network analysis,and intersection with mitochondrial database gene sets,four hub genes associated with AD were identified.These four hub genes were subsequently validated in APP/PS1 and 5xFAD mouse models using molecular biology techniques.Results:The hub genes identified through bioinformatics analysis include SYNJ2BP,VDAC1,NUBPL,and COX19.Within the GSE132903 dataset,the expression levels of SYNJ2BP,NUBPL,and COX19 were significantly elevated in the AD group compared to the non-demented(ND)group,whereas VDAC1 expression was reduced in the AD group relative to the ND group.Furthermore,in the hippocampus of APP/PS1 and 5xFAD mouse models,the expression patterns of SYNJ2BP and NUBPL were consistent with the bioinformatics analysis results.Conclusion:Hub genes identified here through bioinformatics and molecular biology may help early diagnosis of AD patients and may also help build new AD models to explore its pathogenesis. 展开更多
关键词 Alzheimer's disease diagnostic model hub gene mitochondria
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