期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到4篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Advances and applications of brain organoids in central nervous system disorders:Bridging the gap from laboratory to clinic 认领 引用
1
作者 Changle Fang Qiulin Wang +5 位作者 Qiuxia Xiao Xiaoxing Cai Ruolan Du Lulu Xue Xiaohe Tian Liulin Xiong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期2715-2730,共16页
Investigating the mechanisms underlying central nervous system disorders is a major scientific issue in the 21st century.However,the inaccessibility and complexity of the human brain have always represented a challeng... Investigating the mechanisms underlying central nervous system disorders is a major scientific issue in the 21st century.However,the inaccessibility and complexity of the human brain have always represented a challenge in understanding the pathophysiology of the central nervous system.Brain organoids are self-assembled threedimensional aggregates derived from pluripotent stem cells with cell types and structures similar to the embryonic human brain,giving them potential for investigating the atypical cellular,molecular,and genetic characteristics characteristic of central nervous system disorders.Brain organoids also provide a platform for drug screening and serve as a potential source for transplantation therapy for brain injuries.However,the broad application of brain organoids is hampered by several limitations,such as the lack of high-fidelity cell types,insufficient maturation,and considerable heterogeneity,undermining their reliability in specific applications.This review summarizes brain organoid evolution,discusses recent technological and methodological innovations,and reviews their applications in drug screening,transplantation therapy,and disease modeling,as well as clinical research progress.Additionally,we emphasize the limitations of current brain organoid research and explore the potential for advancing the technology to enhance its applicability. 展开更多
关键词 acute brain injury bioengineering brain organoids brain tissue transplantation cerebral organoids drug screening induced pluripotent stem cell neurodegenerative diseases neurodevelopmental disorders
暂未订购 下载PDF
Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy 认领 引用 被引量：5
2
作者 Lulu Xue Ruolan Du +8 位作者 Ning Bi Qiuxia Xiao Yifei Sun Ruize Niu Yaxin Tan Li Chen Jia Liu Tinghua Wang Liulin Xiong 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2027-2035,共9页
Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ische... Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ischemic encephalopathy.The therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been explored.However,the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been investigated.In this study,we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor function.Protein chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model rats.Following transplantation of human placental chorionic plate-derived mesenchymal stem cells,interleukin-3 expression was downregulated.To further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy,we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering RNA.We found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 knockdown.Furthermore,interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic encephalopathy.The findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy,and this effect was mediated by interleukin-3-dependent neurological function. 展开更多
关键词 behavioral evaluations gene knockout human neuroblastoma cells(SH-SY5Y) human placental chorionic derived mesenchymal stem cells interleukin-3 neonatal hypoxic-ischemic encephalopathy nerve injury oxygen-glucose deprivation protein chip small interfering RNA
暂未订购 下载PDF
Creation of fragrant peanut using CRISPR/Cas9 认领 引用 被引量：2
3
作者 Lulu Xue Pengyu Qu +9 位作者 Huanhuan Zhao Han Liu Bingyan Huang Xiaobo Wang Zhongxin Zhang Xiaodong Dai Li Qin Wenzhao Dong Lei Shi Xinyou Zhang 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2025年第6期1438-1440,共3页
Peanut (Arachis hypogaea L.) is an important food and oil crop valued for its oil-rich kernel, high protein content, and diverse nutritional components, making it a staple raw material in the food industry. Fragrance ... Peanut (Arachis hypogaea L.) is an important food and oil crop valued for its oil-rich kernel, high protein content, and diverse nutritional components, making it a staple raw material in the food industry. Fragrance is an essential trait influencing both the initial appeal and flavor quality of food products. For instance, fragrant rice has gained global popularity due to its appealing aroma. The fragrance trait in rice is regulated by the BADH2 gene, which encodes betaine aldehyde dehydrogenase 2 (BADH) (Chen et al., 2008). In non-fragrant rice, BADH2 catalyzes the conversion of γ-aminobutyraldehyde (GABald) to γ-aminobutyric acid. When BADH2 function is disrupted, GABald is redirected to form Δ-1-pyrroline and the subsequent 2-acetyl-1-pyrroline (2-AP), the key compound contributing to rice fragrance (Okpala et al., 2019). 展开更多
关键词 fragrance nutritional components betaine aldehyde dehydrogenase fragrant rice food industry raw material food products badh gene
暂未订购 下载PDF
Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy 认领 引用 被引量：6
4
作者 Kamila Butowska Xuexiang Han +7 位作者 Ningqiang Gong Rakan El-Mayta Rebecca MHaley Lulu Xue Wenqun Zhong Wei Guo Karin Wang Michael J.Mitchell 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第4期1429-1437,共9页
Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is overexpressed.Therapeuti... Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is overexpressed.Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subject of extensive clinical testing in combination with chemotherapy.Therefore,the development of co-delivery systems for Bcl-2 targeting agents,such as small interfering RNA(siRNA),and chemotherapeutics,such as doxorubicin(DOX),holds promise for enabling combination cancer therapies.Lipid nanoparticles(LNPs)are a clinically advanced nucleic acid delivery system with a compact structure suitable for siRNA encapsulation and delivery.Inspired by ongoing clinical trials of albumin-hitchhiking doxorubicin prodrugs,here we developed a DOX-siRNA co-delivery strategy via conjugation of doxorubicin to the surface of siRNAloaded LNPs.Our optimized LNPs enabled potent knockdown of Bcl-2 and efficient delivery of DOX into the nucleus of Burkitts'lymphoma(Raji)cells,leading to effective inhibition of tumor growth in a mouse model of lymphoma.Based on these results,our LNPs may provide a platform for the co-delivery of various nucleic acids and DOX for the development of new combination cancer therapies. 展开更多
关键词 Lipid nanoparticles Doxorubicin Bcl-2 siRNA delivery Chemotherapy Lymphoma
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈