Plant height is an essential characteristic of agronomic traits,and an ideal plant height is essential for achieving high crop yields.Foxtail millet(Setaria italica)has become a novel diploid C4 model crop.The prot...Plant height is an essential characteristic of agronomic traits,and an ideal plant height is essential for achieving high crop yields.Foxtail millet(Setaria italica)has become a novel diploid C4 model crop.The proteomic profiles of the internode,node,and leaf in two foxtail millet varieties with different heights,Ci846 and Yugu 18,were investigated at the jointing stage in this study.There were different degrees of enrichment in various processes,such as plant hormone signal transduction,the MAPK signaling pathway,and others.In particular,the proper content of auxin could activate downstream SiARFsSiSAURs expression,which enhances the length of internodes.Haplotype analysis of SiSAUR-like revealed two differential haplotypes of associated plant height,Hap1 and Hap2.The molecular marker SiSAUR-like-FCM1-2 can effectively separate materials into Hap1 and Hap2.Two additional genes,designated SiGH3 and SiTCH4,were found to be associated with plant height regulation.In conclusion,this study not only uncovers the crucial role of auxin regulators in modulating plant height during the jointing stage but also provides molecular markers that will be invaluable for molecular breeding efforts.The findings of this research help to elucidate the molecular mechanisms of plant height determination that can be used for crop variety innovation and breeding.展开更多
Background:The gut microbiome has emerged as a critical modulator of cancer immunotherapy response.However,the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer(P...Background:The gut microbiome has emerged as a critical modulator of cancer immunotherapy response.However,the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer(PC)remain not fully explored.The study aimed to explore how gut metabolites regulate death-ligand 1(PD-L1)blockade via exosomes and boost immune checkpoint inhibitors(ICIs)in PC.Methods:We recruited 70 PC patients to set up into five subgroups.The integrated multi-omics analysis was performed.In parallel,we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines and transgenic adenocarcinoma of the mouse prostate(TRAMP)models.Results:We identified two metabolites,16(R)-Hydroxyeicosatetraenoic acid(16(R)-HETE)and 6-Keto-Prostaglandin E1(6-Keto-PGE1),that positively correlated with the plasma exosomal PD-L1 levels.The in vitro experiments found that both 16(R)-HETE and 6-Keto-PGE1 can enhance PD-L1 expression at the mRNA,protein,and exosome levels in both human and mouse PC cell lines,which were also validated in vivo based on subcutaneous mouse models.Both metabolites significantly promoted the anti-PD-L1 efficacy against PC in situ on a TRAMP mouse model.Conclusions:Targeting the“gut-tumor metabolic axis”is a promising strategy to improve the efficacy of immune checkpoint inhibitors in tumors.展开更多
Background:Dysregulation of enhancer transcription occurs in multiple cancers.Enhancer RNAs(eRNAs)are transcribed products from enhancers that play critical roles in transcriptional control.Characterizing the genetic ...Background:Dysregulation of enhancer transcription occurs in multiple cancers.Enhancer RNAs(eRNAs)are transcribed products from enhancers that play critical roles in transcriptional control.Characterizing the genetic basis of eRNA expression may elucidate the molecular mechanisms underlying cancers.Methods:Initially,a comprehensive analysis of eRNA quantitative trait loci(eRNAQTLs)was performed in The Cancer Genome Atlas(TCGA),and functional features were characterized using multi-omics data.To establish the first eRNAQTL profiles for colorectal cancer(CRC)in China,epigenomic data were used to define active enhancers,which were subsequently integrated with transcription and genotyping data from 154 paired CRC samples.Finally,largescale case-control studies(34,585 cases and 69,544 controls)were conducted along with multipronged experiments to investigate the potential mechanisms by which candidate eRNAQTLs affect CRC risk.Results:A total of 300,112 eRNAQTLs were identified across 30 different cancer types,which exert their influence on eRNA transcription by modulating chromatin status,binding affinity to transcription factors and RNA-binding proteins.These eRNAQTLs were found to be significantly enriched in cancer risk loci,explaining a substantial proportion of cancer heritability.Additionally,tumor-specific eRNAQTLs exhibited high responsiveness to the development of cancer.Moreover,the target genes of these eRNAs were associated with dysregulated signaling pathways and immune cell infiltration in cancer,highlighting their potential as therapeutic targets.Furthermore,multiple ethnic population studies have confirmed that an eRNAQTL rs3094296-T variant decreases the risk of CRC in populations from China(OR=0.91,95%CI 0.88–0.95,P=2.92×10-7)and Europe(OR=0.92,95%CI 0.88–0.95,P=4.61×10-6).Mechanistically,rs3094296 had an allele-specific effect on the transcription of the eRNA ENSR00000155786,which functioned as a transcriptional activator promoting the expression of its target gene SENP7.These two genes synergistically suppressed tumor cell proliferation.Our curated list of variants,genes,and drugs has been made available in CancereRNAQTL(http://gffzz7ae2bb80e0cc4912h6ucbxw9wcfuf6bcw.ffgz.tsg.suse.edu.cn/#/)to serve as an informative resource for advancing this field.Conclusion:Our findings underscore the significance of eRNAQTLs in transcriptional regulation and disease heritability,pinpointing the potential of eRNA-based therapeutic strategies in cancers.展开更多
The development of efficient and durable electrocatalysts for oxygen reduction reaction(ORR)holds a pivotal significance in the successful commercialization of proton exchange membrane fuel cells(PEMFCs)but is still c...The development of efficient and durable electrocatalysts for oxygen reduction reaction(ORR)holds a pivotal significance in the successful commercialization of proton exchange membrane fuel cells(PEMFCs)but is still challenging.Herein,we report a worm-liked PtCu nanocrystals dispersed on nitrogen-doped carbon hollow microspheres(Pt0.38Cu0.62/N-HCS).Benefiting from its structural and compositional advantages,the resulting Pt0.38Cu0.62/N-HCS catalyst delivers exceptional electrocatalytic activity for ORR,with a half-wave potential(E1/2)of 0.837 V,a mass activity of 0.672 A mgPt-1,and a Tafel slope of 50.66 mV dec-1,surpassing that of commercial Pt/C.Moreover,the Pt0.38Cu0.62/N-HCS follows the desired four-electron transfer mechanism throughout the ORR process,thereby displaying a high selectivity for direct reduction of O2to H2O.Remarkably,this catalyst also showcases high stability,with only a 25 mV drop in E1/2after 10,000 cycles in an acidic electrolyte.Theoretical calculations elucidate the incorporation of Cu into Pt lattice induces compressive strain,which effectively tailors the d band center of Pt active sites and strengthens the surface chemisorption of O2molecules on PtCu alloys.Consequently,the Pt0.38Cu0.62/N-HCS catalyst exhibits an improved ability to adsorb O2molecules on its surface,accelerating the reaction kinetics of O2conversion to*OOH.Additionally,Cu atoms,not only serving as sacrificial anode,undergo preferential oxidation during PEMFCs operation when compared to Pt,but also the stable Cu species in PtCu alloys contributes significantly to maintaining the strain effect,collectively enhancing both activity and durability.Overall,this research offers an effective and promising approach to enhance the activity and stability of Pt-based ORR electrocatalysts in PEMFCs.展开更多
New fossils pertaining to the oldest known Asian plesiadapiform, the Gashatan carpolestid Subengius mengi, clarify aspects of the dental anatomy of this taxon. The dentition of S. mengi is substantially more primitive...New fossils pertaining to the oldest known Asian plesiadapiform, the Gashatan carpolestid Subengius mengi, clarify aspects of the dental anatomy of this taxon. The dentition of S. mengi is substantially more primitive than previously recognized in retaining a lower dental formula of 2.1.3.3, a low-crowned p4 with three main cusps that are less fully connate than their counterparts in species of Elphidotarsius, P3 with a narrower and structurally simpler lingual margin, and in lacking widely splayed paraconid and metaconid on ml. The unique structure of P3 in S. mengi and a reassessment of P3 anatomy in Elphidotarsius sp., cf. E. florencae, suggest that certain cusp homologies on P3 in Carpolestidae have been misinterpreted in the past. Following a detailed character analysis, the phylogenetic relationships of carpolestids and their close relatives are reconstructed. The Bumbanian taxon Chronolestes simul is recovered as the most basal member of Carpolestidae. S. mengi and a second Bumbanian taxon, Carpocristes oriens, also appear to be relatively basal members of the carpolestid radiation, although none of these Asian carpolestid taxa seems to be specially related to each other. Dispersal of carpolestids between Asia and North America appears to have been restricted to earlier parts of the Paleocene, although carpolestids survived on both continents until sometime near the Paleocene-Eocene boundary.展开更多
In this paper,a linear optimization method(LOM)for the design of terahertz circuits is presented,aimed at enhancing the simulation efficacy and reducing the time of the circuit design workflow.This method enables the ...In this paper,a linear optimization method(LOM)for the design of terahertz circuits is presented,aimed at enhancing the simulation efficacy and reducing the time of the circuit design workflow.This method enables the rapid determination of optimal embedding impedance for diodes across a specific bandwidth to achieve maximum efficiency through harmonic balance simulations.By optimizing the linear matching circuit with the optimal embedding impedance,the method effectively segregates the simulation of the linear segments from the nonlinear segments in the frequency multiplier circuit,substantially improving the speed of simulations.The design of on-chip linear matching circuits adopts a modular circuit design strategy,incorporating fixed load resistors to simplify the matching challenge.Utilizing this approach,a 340 GHz frequency doubler was developed and measured.The results demonstrate that,across a bandwidth of 330 GHz to 342 GHz,the efficiency of the doubler remains above 10%,with an input power ranging from 98 mW to 141mW and an output power exceeding 13 mW.Notably,at an input power of 141 mW,a peak output power of 21.8 mW was achieved at 334 GHz,corresponding to an efficiency of 15.8%.展开更多
In wideband noncooperative interference cancellation,the reference signals obtained through auxiliary antennas are weighted to cancel with the interference signal.The correlation between the reference signal and the i...In wideband noncooperative interference cancellation,the reference signals obtained through auxiliary antennas are weighted to cancel with the interference signal.The correlation between the reference signal and the interference signal determines interference cancellation performance,while the auxiliary antenna array affects the correlation by influencing the amplitude and phase of the reference signals.This paper analyzes the effect of auxiliary antenna array on multiple performances of wideband noncooperative interference cancellation.Firstly,the array received signal model of wideband interference is established,and the weight vector coupled with the auxiliary antennas array manifold is solved by spectral analysis and eigen-subspace decomposition.Then,multiple performances which include cancellation resolution,grating null,wideband interference cancellation ratio(ICR),and convergence rate are quantitatively characterized with the auxiliary antenna array.It is obtained through analysis that the performances mutually restrict the auxiliary antenna array.Higher cancellation resolution requires larger array aperture,but when the number of auxiliary antennas is fixed,larger array aperture results in more grating nulls.When the auxiliary antennas are closer to the main antenna,the wideband ICR is improved,but the convergence rate is reduced.The conclusions are verified through simulation of one-dimensional uniform array and two-dimensional nonuniform array.The experiments of three arrays are compared,and the results conform well with simulation and support the theoretical analysis.展开更多
Through reviewing development history of concession gardens in Tianjin City,features,advantages and problems of these gardens were analyzed.It was stressed that cultural context should be inherited,and features of the...Through reviewing development history of concession gardens in Tianjin City,features,advantages and problems of these gardens were analyzed.It was stressed that cultural context should be inherited,and features of the city highlighted.The gardens should be protected from the perspective of development,combined with urban green space system,integrated with cultural life of local citizens,and coordinated with contemporary architectural style of the city.In addition,plant landscapes should be enriched,and infrastructure of the gardens supplemented to properly handle the relationship between urban construction and protection of historical image,and provide reference for inheriting cultural context of the city in the urban development.展开更多
In this study,we analyzed the characteristics of three-dimensional excitation-emission matrix spectra(EEMs)of 150 samples from five industrial wastewater types and domestic sewage to track water pollution sources effe...In this study,we analyzed the characteristics of three-dimensional excitation-emission matrix spectra(EEMs)of 150 samples from five industrial wastewater types and domestic sewage to track water pollution sources effectively.We then developed a recognition model for wastewater EEMs by establishing a feature dataset containing fluorescence peak values and parameters derived from EEMs,integrated with machine learning techniques.This model enables the rapid and precise identification of pollution sources.Our findings suggest that although the EEMs of the sixwastewater categories are distinct,visual differentiation is challenging.This was confirmed by cosine similarity assessments,showing some samples with low within-group(0.95)similarities.Despite significant variations in EEMs features acrosswastewater categories,identifying specific pollutants remains difficult,especially for pulp mills and leather effluents.Among the tested classification algorithms,Support Vector Machine(SVM)achieved the highest performance with91.7%accuracy,94%precision,91%recall,and 92%F1-score,outperforming K-Nearest Neighbors and Partial Least Squares Discriminant Analysis.The SVM significantly improved identification accuracy for pulpmill and leather processing wastewaters compared to other models.To enhance identification accuracy,further exploration of EEMs features and expanding the training dataset are recommended.Combining EEMs features with machine learning presents a promising method for improvingwater pollution supervision and source tracing in environmental management practices.展开更多
Through the overview of the development history of Tianjin Concession Parks, this paper analyzed the historical significance of Tianjin Concession Parks and put forward its existing problems, then summed up a series o...Through the overview of the development history of Tianjin Concession Parks, this paper analyzed the historical significance of Tianjin Concession Parks and put forward its existing problems, then summed up a series of strategies of sustainable development as follows: adhering to the Florence Charter; retaining the original form and texture of the Concession Parks; adopting a dynamic philosophy of protection and preservation; integrating with citizens' social life; supplementing and improving infrastructure facilities; and achieving environmental regeneration by planting. All these efforts are expected to contribute to making a balance between the development and construction of urban cities and the preservation of historical features, as well as provide lessons for inheriting urban history and culture in the future.展开更多
Although multifunctional electromagnetic interference(EMI)shielding materials with ultrahigh electromagnetic wave absorption are highly required to solve increasingly serious electromagnetic radiation and pollution an...Although multifunctional electromagnetic interference(EMI)shielding materials with ultrahigh electromagnetic wave absorption are highly required to solve increasingly serious electromagnetic radiation and pollution and meet multi-scenario applications,EMI shielding materials usually cause a lot of reflection and have a single function.To realize the broadband absorption-dominated EMI shielding via absorption-reflection-reabsorption mechanisms and the interference cancelation effect,multifunctional asymmetric bilayer aerogels are designed by sequential printing of a MXene-graphene oxide(MG)layer with a MG emulsion ink and a conductive MXene layer with a MXene ink and subsequent freeze-drying for generating and solidifying numerous pores in the aerogels.The top MG layer of the asymmetric bilayer aerogel optimizes impedance matching and achieves re-absorption,while the bottom MXene layer enhances the reflection of the incident electromagnetic waves.As a result,the asymmetric bilayer aerogel achieves an average absorption coefficient of 0.95 in the X-band and shows the tunable absorption ability to electromagnetic wave in the ultrawide band from 8.2 to 40 GHz.Finite element simulations substantiate the effectiveness of the asymmetric bilayer aerogel for electromagnetic wave absorption.The multifunctional bilayer aerogels exhibit hydrophobicity,thermal insulation and Joule heating capacities and are efficient in solar-thermal/electric heating,infrared stealth,and clean-up of spilled oil.展开更多
We report new material of the zalambdalestid,Zhangolestes jilinensis,from the Quantou Formation(lower Upper Cretaceous,Cenomanian to Turonian),Gongzhuling City,Jilin Province,NE China.Using micro-CT-scan,the material ...We report new material of the zalambdalestid,Zhangolestes jilinensis,from the Quantou Formation(lower Upper Cretaceous,Cenomanian to Turonian),Gongzhuling City,Jilin Province,NE China.Using micro-CT-scan,the material is shown to include dentocranial and postcranial elements recovered from the same matrix block containing the holotype specimen.The CT-images also show the labial and internal structures of the holotype fragment of the lower jaw of Z.jilinensis.Based on the preservation,relative size,and tooth wear,the new material and the holotype lower jaw likely belong to the same individual animal,whereas the hypodigm mandibular fragment assigned to Z.jilinensis in the original study is thought now to belong to a different individual,potentially representing a different species,which,if true,would increase the eutherian diversity in the Late Cretaceous Changchunsaurus Fauna.Furthermore,the new CT-images show that the incisor morphology is diverse within zalambdalestids and probably evolved independently from the enlarged incisors in placental mammals,such as Glires.展开更多
基金supported by the grants from the National Natural Science Foundation of China(32241042)the Science Research Project of Hebei Education Department,China(BJ2021029)+1 种基金the Natural Science Foundation for Excellent Youth Scholars of Hebei Province,China(C2021205011)the Graduate innovation Funding Project of Hebei Normal University,China(XCXZZSS202337)。
摘要Plant height is an essential characteristic of agronomic traits,and an ideal plant height is essential for achieving high crop yields.Foxtail millet(Setaria italica)has become a novel diploid C4 model crop.The proteomic profiles of the internode,node,and leaf in two foxtail millet varieties with different heights,Ci846 and Yugu 18,were investigated at the jointing stage in this study.There were different degrees of enrichment in various processes,such as plant hormone signal transduction,the MAPK signaling pathway,and others.In particular,the proper content of auxin could activate downstream SiARFsSiSAURs expression,which enhances the length of internodes.Haplotype analysis of SiSAUR-like revealed two differential haplotypes of associated plant height,Hap1 and Hap2.The molecular marker SiSAUR-like-FCM1-2 can effectively separate materials into Hap1 and Hap2.Two additional genes,designated SiGH3 and SiTCH4,were found to be associated with plant height regulation.In conclusion,this study not only uncovers the crucial role of auxin regulators in modulating plant height during the jointing stage but also provides molecular markers that will be invaluable for molecular breeding efforts.The findings of this research help to elucidate the molecular mechanisms of plant height determination that can be used for crop variety innovation and breeding.
基金supported by Tianjian advanced biomedical laboratory key research and development projectHenan Province Natural Science Foundation(Grant Number 242300421283)Major Science and Technology Project of Henan Province(221100310200)。
摘要Background:The gut microbiome has emerged as a critical modulator of cancer immunotherapy response.However,the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer(PC)remain not fully explored.The study aimed to explore how gut metabolites regulate death-ligand 1(PD-L1)blockade via exosomes and boost immune checkpoint inhibitors(ICIs)in PC.Methods:We recruited 70 PC patients to set up into five subgroups.The integrated multi-omics analysis was performed.In parallel,we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines and transgenic adenocarcinoma of the mouse prostate(TRAMP)models.Results:We identified two metabolites,16(R)-Hydroxyeicosatetraenoic acid(16(R)-HETE)and 6-Keto-Prostaglandin E1(6-Keto-PGE1),that positively correlated with the plasma exosomal PD-L1 levels.The in vitro experiments found that both 16(R)-HETE and 6-Keto-PGE1 can enhance PD-L1 expression at the mRNA,protein,and exosome levels in both human and mouse PC cell lines,which were also validated in vivo based on subcutaneous mouse models.Both metabolites significantly promoted the anti-PD-L1 efficacy against PC in situ on a TRAMP mouse model.Conclusions:Targeting the“gut-tumor metabolic axis”is a promising strategy to improve the efficacy of immune checkpoint inhibitors in tumors.
基金supported by the National Science Fund for Excellent Young Scholars(NSFC-82322058)the Program of National Natural Science Foundation of China(NSFC-82103929,NSFC-82273713)+10 种基金the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)the National Science Fund for Distinguished Young Scholars of Hubei Province of China(2023AFA046)the Fundamental Research Funds for the Central Universities(WHU:2042022kf1205)Fundamental Research Funds for the Central Universities(WHU:2042022kf1031)for Ying Zhuthe Fundamental Research Funds for the Central Universities(2042022rc0026,2042023kf1005)for Xiao-Ping Miaothe Knowledge Innovation Program of Wuhan(whkxjsj011,2023020201010073)for Jian-Bo Tianthe Science and Technology Innovation Seed Fund of Zhongnan Hospital of Wuhan University(znpy2019060)for Yong-Chang Weithe Distinguished Young Scholars of China(NSFC-81925032)the Key Program of National Natural Science Foundation of China(NSFC-82130098)the Youth Program of National Natural Science Foundation of China(NSFC-82003547)the Program of Health Commission of Hubei Province(WJ2023M045)。
摘要Background:Dysregulation of enhancer transcription occurs in multiple cancers.Enhancer RNAs(eRNAs)are transcribed products from enhancers that play critical roles in transcriptional control.Characterizing the genetic basis of eRNA expression may elucidate the molecular mechanisms underlying cancers.Methods:Initially,a comprehensive analysis of eRNA quantitative trait loci(eRNAQTLs)was performed in The Cancer Genome Atlas(TCGA),and functional features were characterized using multi-omics data.To establish the first eRNAQTL profiles for colorectal cancer(CRC)in China,epigenomic data were used to define active enhancers,which were subsequently integrated with transcription and genotyping data from 154 paired CRC samples.Finally,largescale case-control studies(34,585 cases and 69,544 controls)were conducted along with multipronged experiments to investigate the potential mechanisms by which candidate eRNAQTLs affect CRC risk.Results:A total of 300,112 eRNAQTLs were identified across 30 different cancer types,which exert their influence on eRNA transcription by modulating chromatin status,binding affinity to transcription factors and RNA-binding proteins.These eRNAQTLs were found to be significantly enriched in cancer risk loci,explaining a substantial proportion of cancer heritability.Additionally,tumor-specific eRNAQTLs exhibited high responsiveness to the development of cancer.Moreover,the target genes of these eRNAs were associated with dysregulated signaling pathways and immune cell infiltration in cancer,highlighting their potential as therapeutic targets.Furthermore,multiple ethnic population studies have confirmed that an eRNAQTL rs3094296-T variant decreases the risk of CRC in populations from China(OR=0.91,95%CI 0.88–0.95,P=2.92×10-7)and Europe(OR=0.92,95%CI 0.88–0.95,P=4.61×10-6).Mechanistically,rs3094296 had an allele-specific effect on the transcription of the eRNA ENSR00000155786,which functioned as a transcriptional activator promoting the expression of its target gene SENP7.These two genes synergistically suppressed tumor cell proliferation.Our curated list of variants,genes,and drugs has been made available in CancereRNAQTL(http://gffzz7ae2bb80e0cc4912h6ucbxw9wcfuf6bcw.ffgz.tsg.suse.edu.cn/#/)to serve as an informative resource for advancing this field.Conclusion:Our findings underscore the significance of eRNAQTLs in transcriptional regulation and disease heritability,pinpointing the potential of eRNA-based therapeutic strategies in cancers.
基金the Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX0557,cstb2023nscq-msx0979)+3 种基金Talent Introduction of Chongqing University of Science and Technology(ckrc2021050,ckrc20230401,ckrc2021053)the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202201532,KJQN202301542)the National Natural Science Foundation of China(22109016)Open Research Fund of CNMGE Platform&NSCC-TJ(CNMGE2023016).
摘要The development of efficient and durable electrocatalysts for oxygen reduction reaction(ORR)holds a pivotal significance in the successful commercialization of proton exchange membrane fuel cells(PEMFCs)but is still challenging.Herein,we report a worm-liked PtCu nanocrystals dispersed on nitrogen-doped carbon hollow microspheres(Pt0.38Cu0.62/N-HCS).Benefiting from its structural and compositional advantages,the resulting Pt0.38Cu0.62/N-HCS catalyst delivers exceptional electrocatalytic activity for ORR,with a half-wave potential(E1/2)of 0.837 V,a mass activity of 0.672 A mgPt-1,and a Tafel slope of 50.66 mV dec-1,surpassing that of commercial Pt/C.Moreover,the Pt0.38Cu0.62/N-HCS follows the desired four-electron transfer mechanism throughout the ORR process,thereby displaying a high selectivity for direct reduction of O2to H2O.Remarkably,this catalyst also showcases high stability,with only a 25 mV drop in E1/2after 10,000 cycles in an acidic electrolyte.Theoretical calculations elucidate the incorporation of Cu into Pt lattice induces compressive strain,which effectively tailors the d band center of Pt active sites and strengthens the surface chemisorption of O2molecules on PtCu alloys.Consequently,the Pt0.38Cu0.62/N-HCS catalyst exhibits an improved ability to adsorb O2molecules on its surface,accelerating the reaction kinetics of O2conversion to*OOH.Additionally,Cu atoms,not only serving as sacrificial anode,undergo preferential oxidation during PEMFCs operation when compared to Pt,but also the stable Cu species in PtCu alloys contributes significantly to maintaining the strain effect,collectively enhancing both activity and durability.Overall,this research offers an effective and promising approach to enhance the activity and stability of Pt-based ORR electrocatalysts in PEMFCs.
摘要New fossils pertaining to the oldest known Asian plesiadapiform, the Gashatan carpolestid Subengius mengi, clarify aspects of the dental anatomy of this taxon. The dentition of S. mengi is substantially more primitive than previously recognized in retaining a lower dental formula of 2.1.3.3, a low-crowned p4 with three main cusps that are less fully connate than their counterparts in species of Elphidotarsius, P3 with a narrower and structurally simpler lingual margin, and in lacking widely splayed paraconid and metaconid on ml. The unique structure of P3 in S. mengi and a reassessment of P3 anatomy in Elphidotarsius sp., cf. E. florencae, suggest that certain cusp homologies on P3 in Carpolestidae have been misinterpreted in the past. Following a detailed character analysis, the phylogenetic relationships of carpolestids and their close relatives are reconstructed. The Bumbanian taxon Chronolestes simul is recovered as the most basal member of Carpolestidae. S. mengi and a second Bumbanian taxon, Carpocristes oriens, also appear to be relatively basal members of the carpolestid radiation, although none of these Asian carpolestid taxa seems to be specially related to each other. Dispersal of carpolestids between Asia and North America appears to have been restricted to earlier parts of the Paleocene, although carpolestids survived on both continents until sometime near the Paleocene-Eocene boundary.
基金Supported by the Beijing Municipal Science&Technology Commission(Z211100004421012),the Key Reaserch and Development Pro⁃gram of China(2022YFF0605902)。
摘要In this paper,a linear optimization method(LOM)for the design of terahertz circuits is presented,aimed at enhancing the simulation efficacy and reducing the time of the circuit design workflow.This method enables the rapid determination of optimal embedding impedance for diodes across a specific bandwidth to achieve maximum efficiency through harmonic balance simulations.By optimizing the linear matching circuit with the optimal embedding impedance,the method effectively segregates the simulation of the linear segments from the nonlinear segments in the frequency multiplier circuit,substantially improving the speed of simulations.The design of on-chip linear matching circuits adopts a modular circuit design strategy,incorporating fixed load resistors to simplify the matching challenge.Utilizing this approach,a 340 GHz frequency doubler was developed and measured.The results demonstrate that,across a bandwidth of 330 GHz to 342 GHz,the efficiency of the doubler remains above 10%,with an input power ranging from 98 mW to 141mW and an output power exceeding 13 mW.Notably,at an input power of 141 mW,a peak output power of 21.8 mW was achieved at 334 GHz,corresponding to an efficiency of 15.8%.
基金supported by the National Fund for Distinguished Young Scholars(52025072)the National Natural Science Foundation of China(52177012)the Foundation of National Key Laboratory of Science and Technology(614221722051301).
摘要In wideband noncooperative interference cancellation,the reference signals obtained through auxiliary antennas are weighted to cancel with the interference signal.The correlation between the reference signal and the interference signal determines interference cancellation performance,while the auxiliary antenna array affects the correlation by influencing the amplitude and phase of the reference signals.This paper analyzes the effect of auxiliary antenna array on multiple performances of wideband noncooperative interference cancellation.Firstly,the array received signal model of wideband interference is established,and the weight vector coupled with the auxiliary antennas array manifold is solved by spectral analysis and eigen-subspace decomposition.Then,multiple performances which include cancellation resolution,grating null,wideband interference cancellation ratio(ICR),and convergence rate are quantitatively characterized with the auxiliary antenna array.It is obtained through analysis that the performances mutually restrict the auxiliary antenna array.Higher cancellation resolution requires larger array aperture,but when the number of auxiliary antennas is fixed,larger array aperture results in more grating nulls.When the auxiliary antennas are closer to the main antenna,the wideband ICR is improved,but the convergence rate is reduced.The conclusions are verified through simulation of one-dimensional uniform array and two-dimensional nonuniform array.The experiments of three arrays are compared,and the results conform well with simulation and support the theoretical analysis.
摘要Through reviewing development history of concession gardens in Tianjin City,features,advantages and problems of these gardens were analyzed.It was stressed that cultural context should be inherited,and features of the city highlighted.The gardens should be protected from the perspective of development,combined with urban green space system,integrated with cultural life of local citizens,and coordinated with contemporary architectural style of the city.In addition,plant landscapes should be enriched,and infrastructure of the gardens supplemented to properly handle the relationship between urban construction and protection of historical image,and provide reference for inheriting cultural context of the city in the urban development.
基金supported by the Leading Talent of the Science and Technology Nova Program of Zhejiang(No.2020R52039)the Outstanding Innovative Team Supporting Plan of Jiaxing City(No.2022-LHYJ-02-0503-02)+1 种基金the Key Research Project of Yangtze Delta Region Institute of Tsinghua University(No.2023ZQZ005)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22-1386).
摘要In this study,we analyzed the characteristics of three-dimensional excitation-emission matrix spectra(EEMs)of 150 samples from five industrial wastewater types and domestic sewage to track water pollution sources effectively.We then developed a recognition model for wastewater EEMs by establishing a feature dataset containing fluorescence peak values and parameters derived from EEMs,integrated with machine learning techniques.This model enables the rapid and precise identification of pollution sources.Our findings suggest that although the EEMs of the sixwastewater categories are distinct,visual differentiation is challenging.This was confirmed by cosine similarity assessments,showing some samples with low within-group(0.95)similarities.Despite significant variations in EEMs features acrosswastewater categories,identifying specific pollutants remains difficult,especially for pulp mills and leather effluents.Among the tested classification algorithms,Support Vector Machine(SVM)achieved the highest performance with91.7%accuracy,94%precision,91%recall,and 92%F1-score,outperforming K-Nearest Neighbors and Partial Least Squares Discriminant Analysis.The SVM significantly improved identification accuracy for pulpmill and leather processing wastewaters compared to other models.To enhance identification accuracy,further exploration of EEMs features and expanding the training dataset are recommended.Combining EEMs features with machine learning presents a promising method for improvingwater pollution supervision and source tracing in environmental management practices.
基金Sponsored by Art and Science Planning Foundation of Tianjin City(A12069)
摘要Through the overview of the development history of Tianjin Concession Parks, this paper analyzed the historical significance of Tianjin Concession Parks and put forward its existing problems, then summed up a series of strategies of sustainable development as follows: adhering to the Florence Charter; retaining the original form and texture of the Concession Parks; adopting a dynamic philosophy of protection and preservation; integrating with citizens' social life; supplementing and improving infrastructure facilities; and achieving environmental regeneration by planting. All these efforts are expected to contribute to making a balance between the development and construction of urban cities and the preservation of historical features, as well as provide lessons for inheriting urban history and culture in the future.
基金the National Natural Science Foundation of China(52090034,52273064,52221006)the Fundamental Research Funds for the Central Universities(JD2417)is gratefully acknowledged.
摘要Although multifunctional electromagnetic interference(EMI)shielding materials with ultrahigh electromagnetic wave absorption are highly required to solve increasingly serious electromagnetic radiation and pollution and meet multi-scenario applications,EMI shielding materials usually cause a lot of reflection and have a single function.To realize the broadband absorption-dominated EMI shielding via absorption-reflection-reabsorption mechanisms and the interference cancelation effect,multifunctional asymmetric bilayer aerogels are designed by sequential printing of a MXene-graphene oxide(MG)layer with a MG emulsion ink and a conductive MXene layer with a MXene ink and subsequent freeze-drying for generating and solidifying numerous pores in the aerogels.The top MG layer of the asymmetric bilayer aerogel optimizes impedance matching and achieves re-absorption,while the bottom MXene layer enhances the reflection of the incident electromagnetic waves.As a result,the asymmetric bilayer aerogel achieves an average absorption coefficient of 0.95 in the X-band and shows the tunable absorption ability to electromagnetic wave in the ultrawide band from 8.2 to 40 GHz.Finite element simulations substantiate the effectiveness of the asymmetric bilayer aerogel for electromagnetic wave absorption.The multifunctional bilayer aerogels exhibit hydrophobicity,thermal insulation and Joule heating capacities and are efficient in solar-thermal/electric heating,infrared stealth,and clean-up of spilled oil.
基金supported by the National Natural Science Foundation of China(Grant Nos.42122010,42072017)the Youth Innovation Promotion Association CAS(Y2023017)+1 种基金the National Mineral Rock and Fossil Specimens Resource Center(NCSTI-RMF20240203)China Geological Survey(DD20230221)。
摘要We report new material of the zalambdalestid,Zhangolestes jilinensis,from the Quantou Formation(lower Upper Cretaceous,Cenomanian to Turonian),Gongzhuling City,Jilin Province,NE China.Using micro-CT-scan,the material is shown to include dentocranial and postcranial elements recovered from the same matrix block containing the holotype specimen.The CT-images also show the labial and internal structures of the holotype fragment of the lower jaw of Z.jilinensis.Based on the preservation,relative size,and tooth wear,the new material and the holotype lower jaw likely belong to the same individual animal,whereas the hypodigm mandibular fragment assigned to Z.jilinensis in the original study is thought now to belong to a different individual,potentially representing a different species,which,if true,would increase the eutherian diversity in the Late Cretaceous Changchunsaurus Fauna.Furthermore,the new CT-images show that the incisor morphology is diverse within zalambdalestids and probably evolved independently from the enlarged incisors in placental mammals,such as Glires.