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Two leucine-rich repeat receptor-like kinases initiate herbivory defense responses in tea plants 认领 引用 被引量：1
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作者 Qi Jiang Changqing Ding +8 位作者 Lingjia Feng Zhenwei Wu Yujie Liu Lintong He Chuande Liu Lu Wang Jianming Zeng Jianyan Huang Meng Ye 《Horticulture Research》 SCIE CSCD 2025年第1期178-191,共14页
Leucine-rich repeat receptor-like kinases(LRR-RLKs)have emerged as key regulators of herbivory perception and subsequent defense initiation.While their functions in grass plants have been gradually elucidated,the role... Leucine-rich repeat receptor-like kinases(LRR-RLKs)have emerged as key regulators of herbivory perception and subsequent defense initiation.While their functions in grass plants have been gradually elucidated,the roles of herbivory-related LRR-RLKs in woody plants remain largely unknown.In this study,we mined the genomic and transcriptomic data of tea plants(Camellia sinensis)and identified a total of 307 CsLRR-RLK members.Phylogenetic analysis grouped these CsLRR-RLKs into 14 subgroups along with their Arabidopsis homologs.Gene structure and conserved domain analyses revealed notable similarities among subgroup members.Among the identified CsLRR-RLKs,we focused on two plasma membrane-localized LRR-RLKs,CsLRR-RLK44,and CsLRR-RLK239,which do not form homodimers or heterodimers with each other.Both respond strongly to herbivory,and their expression patterns significantly correlate with herbivore resistance phenotypes across different tea accessions.CsLRR-RLK44 and CsLRR-RLK239 act upstream of mitogen-activated protein kinase(MPK)cascades and modulate the expression of defense-related MPKs and WRKY transcription factors.Additionally,silencing CsLRR-RLK44 or CsLRR-RLK239 reduced the levels of herbivory-induced jasmonates,thereby weakening the plant resistance to tea geometrid larvae(Ectropis obliqua).Our work is the first to demonstrate that in woody plants,LRR-RLKs are essential for enhancing herbivore resistance through the activation of the canonical signaling,including MPKs,WRKYs,and jasmonates.Furthermore,our study extends mechanistic insights into how LRR-RLKs initiate plant defenses from grasses to economically important tree species. 展开更多
关键词 herbivory defense tea plants camellia signaling pathways woody plants genomic transcriptomic data leucine rich repeat receptor kinases grass plants tea plants
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非恒定流作用下桩基局部冲刷试验研究 认领 引用
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作者 匡磊 崔圣佳 +3 位作者 孟野 梁丙臣 杨博 于杭涛 《水道港口》 2026年第2期214-222,共9页
通过物理模型试验探究了在流速先增大后减小的非恒定流作用下的桩基局部冲刷问题,同时研究了不同水流流速变化加速度对于冲刷坑的影响。结果表明:在流速先增大后减小的非恒定流作用下,桩基周围形成明显的冲刷坑,桩基后方出现淤积的沙坝... 通过物理模型试验探究了在流速先增大后减小的非恒定流作用下的桩基局部冲刷问题,同时研究了不同水流流速变化加速度对于冲刷坑的影响。结果表明:在流速先增大后减小的非恒定流作用下,桩基周围形成明显的冲刷坑,桩基后方出现淤积的沙坝,最大冲刷深度出现在流速减小的初始阶段,且在流速增长阶段冲刷深度即可达到最大冲刷深度的80%。在始终变化的非恒定水流作用下,桩基的冲刷过程仅存在冲刷与回淤阶段,并未观测到动态平衡冲刷阶段。此外,在同一峰值流速的作用下,冲刷坑的最大冲刷深度随着流速变化加速度的减小而增加,且冲刷深度随冲刷历时的延长而加深。试验结果可为继续深入探讨极端非恒定流作用下桩基结构与海床相互作用提供试验依据。 展开更多
关键词 非恒定流 桩基冲刷 床面形态 冲刷深度 挟沙力 泥沙起动
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调脾安神点穴法联合揿针耳穴治疗心脾两虚型小儿抽动秽语综合征的临床效果 认领 引用
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作者 杨治纯 杨会来 +3 位作者 刘伟 马涛 孟烨 李鴳 《临床医学研究与实践》 2026年第17期122-125,共4页
目的探究调脾安神点穴法联合揿针耳穴治疗心脾两虚型小儿抽动秽语综合征(TS)的临床效果。方法选取北京中医药大学东方医院枣庄医院收治且符合小儿TS诊断的66例患儿,采用随机数表法将其分为治疗组和对照组,两组各脱落1例,最终每组32例。... 目的探究调脾安神点穴法联合揿针耳穴治疗心脾两虚型小儿抽动秽语综合征(TS)的临床效果。方法选取北京中医药大学东方医院枣庄医院收治且符合小儿TS诊断的66例患儿,采用随机数表法将其分为治疗组和对照组,两组各脱落1例,最终每组32例。治疗组采用调脾安神点穴法联合揿针耳穴,对照组采用盐酸硫必利片。比较两组的耶鲁综合抽动严重程度量表(YGTSS)评分、中医证候积分及临床疗效。结果治疗后,治疗组的YGTSS评分低于对照组(P<0.05)。治疗后,治疗组的中医证候积分明显低于对照组(P<0.05)。治疗后,两组的整体疗效比较,差异具有统计学意义(P=0.006)。结论调脾安神点穴法联合揿针耳穴治疗小儿TS效果显著,可降低YGTSS评分及中医证候积分。 展开更多
关键词 抽动秽语综合征 调脾安神点穴法 揿针耳穴
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耕作方式和生物炭用量对冬小麦产量、土壤氮碳的影响 认领 引用 被引量：2
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作者 陈海情 张凯 +7 位作者 黄超 王鹏飞 孟晔 安佳慧 刘栩辰 马守田 王兴鹏 刘战东 《麦类作物学报》 CAS CSCD 北大核心 2025年第2期224-233,共10页
为探讨旋耕和深松条件下生物炭施用量对冬小麦产量和土壤碳氮的影响,探寻冬小麦最佳耕作方式和生物炭施用量组合,2021-2023年通过二因素随机区组试验,设置旋耕和深松两种耕作方式,以及0、4.5和9 t·hm-2三个生物炭施用水平,比较... 为探讨旋耕和深松条件下生物炭施用量对冬小麦产量和土壤碳氮的影响,探寻冬小麦最佳耕作方式和生物炭施用量组合,2021-2023年通过二因素随机区组试验,设置旋耕和深松两种耕作方式,以及0、4.5和9 t·hm-2三个生物炭施用水平,比较分析了不同处理间冬小麦产量和土壤碳氮的差异。结果表明,耕作方式和生物炭施用量对麦田土壤硝态氮残留量、总碳含量、全氮含量和微生物量碳、氮含量均有显著影响,两者的交互作用对土壤全氮含量和微生物量碳含量的影响分别在2022和2023年均达到显著水平。在0~20 cm土层,与旋耕相比,深松下土壤总碳含量和全氮含量分别提高13.9%和29.5%,同时深松对20~30 cm土层土壤微生物量碳、氮含量均有促进作用,使土壤硝态氮残留量显著降低8.5%。与不施生物炭相比,施用生物炭对0~30 cm土层土壤微生物量碳、氮含量均有促进作用,并减少0~50 cm土层土壤硝态氮残留量,使总碳和全氮含量增加22.4%和6.7%。在2022和2023年,深松下冬小麦产量较旋耕均显著增加,增幅分别为15.8%和12.0%,其中SSB2处理产量均最高。综合分析表明,深松+9 t·hm-2生物炭效果最好,是高产和提高土壤肥力的耕作与生物碳施用组合,可以应用推广。 展开更多
关键词 施用生物炭 耕作方式 冬小麦 产量 土壤碳 土壤氮
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SDX51D带钢拉矫破鳞前后氧化铁皮分析及酸洗工艺 认领 引用 被引量：2
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作者 孟晔 高国强 +2 位作者 孙莉莉 方锡祯 薛润东 《锻压技术》 CAS CSCD 北大核心 2025年第4期132-140,共9页
酸洗是冷轧产品制造流程中的关键环节,金属材料的表面状态和酸液的浓度、温度、处理时间等因素均会对酸洗效果产生显著影响。利用X射线衍射、扫描电镜和能谱分析研究了SDX51D带钢宽度方向不同部位及拉矫破鳞处理前后的氧化铁皮成分构成... 酸洗是冷轧产品制造流程中的关键环节,金属材料的表面状态和酸液的浓度、温度、处理时间等因素均会对酸洗效果产生显著影响。利用X射线衍射、扫描电镜和能谱分析研究了SDX51D带钢宽度方向不同部位及拉矫破鳞处理前后的氧化铁皮成分构成与结构特征;通过电化学方法研究了带钢宽度方向不同位置、拉矫破鳞前后、酸洗浓度和酸洗温度对酸洗结束时间的影响;采用电位导数首零法判断酸洗结束的时间。研究结果表明:SDX51D带钢宽度方向边部氧化铁皮成分为Fe2O3和Fe3O4,中部成分为Fe3O4和FeO,中部氧化铁皮厚度较边部薄3μm且厚度不均,与基体结合不紧密,酸洗时间较边部减少10 s。拉矫破鳞后的氧化铁皮裂纹增多,厚度平均减少2~3μm,有利于酸洗,酸洗时间较拉矫破鳞前减少20 s。综合考虑SDX51D带钢的酸洗效果,酸洗工艺建议酸洗温度为80℃、酸洗浓度为10%。 展开更多
关键词 拉矫破鳞 氧化铁皮 酸洗浓度 酸洗温度 电位导数首零法
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以持续高热为主要临床表现的鹦鹉热衣原体肺炎延误诊治分析及文献复习 认领 引用 被引量：1
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作者 贾卫红 杨雅菲 +5 位作者 孟晔 郝娜娜 王丽娜 卜丽娜 刘志燕 唐晶晶 《临床误诊误治》 CAS 2025年第1期7-11,共5页
目的探讨鹦鹉热衣原体肺炎的临床特点及延误诊治原因。方法分析2022年1月至2023年12月收治的6例以持续高热为主要临床表现鹦鹉热衣原体肺炎患者的临床资料,总结病例特点、诊疗过程、误诊原因及防范措施。结果6例均急性起病,主要表现为... 目的探讨鹦鹉热衣原体肺炎的临床特点及延误诊治原因。方法分析2022年1月至2023年12月收治的6例以持续高热为主要临床表现鹦鹉热衣原体肺炎患者的临床资料,总结病例特点、诊疗过程、误诊原因及防范措施。结果6例均急性起病,主要表现为持续高热,体温最高42.0℃,有鸟类及家禽接触史3例,其余否认鸟类及家禽接触史。乏力、呼吸困难各5例,食欲减退、头晕各3例,咳嗽咳痰、恶心呕吐、头痛各2例,胸痛、咽干、多汗、腹泻、痰中带血各1例。4例中性粒细胞百分比升高,2例降钙素原升高,2例丙氨酸转氨酶升高,2例肌酸激酶升高。6例影像学检查均有肺实变,表现为片状模糊渗出影,部分边缘不清,内可见支气管充气征。6例均被误诊为普通社区获得性肺炎。误诊时间5~9 d。6例均通过支气管肺泡灌洗液宏基因组二代测序确诊为鹦鹉热衣原体肺炎,予以针对性抗感染治疗后病情好转出院。无死亡病例。结论对于急性起病,高热伴咳嗽、呼吸困难,影像学提示大片状实变渗出影,经过经验性抗感染治疗无效患者,尤其有家禽或鸟类接触史者,需高度怀疑鹦鹉热衣原体肺炎,必要时行支气管肺泡灌洗液宏基因组二代测序,以早期确诊,减少误诊误治,尽早给予针对性治疗,能避免疾病向危重症发展。 展开更多
关键词 鹦鹉热衣原体 肺炎 高热 误诊 社区获得性肺炎 支气管镜 肺泡灌洗液 宏基因组二代测序
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以“体验—建构—表现”为路径的扫描电镜实验教学改革 认领 引用 被引量：1
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作者 王晶 孟晔 +3 位作者 曹文斌 林玮 马核 薛润东 《实验室研究与探索》 CAS 北大核心 2025年第11期90-95,共6页
为解决扫描电镜实验教学中普遍存在的设备操作复杂度高与教学普适性需求矛盾、理论认知壁垒显著、实践教学深度交互与认知溯源不足3大瓶颈问题,本文创新性地提出“体验—建构—表现”学习路径,并构建了以拆装实训平台为核心的教学体系... 为解决扫描电镜实验教学中普遍存在的设备操作复杂度高与教学普适性需求矛盾、理论认知壁垒显著、实践教学深度交互与认知溯源不足3大瓶颈问题,本文创新性地提出“体验—建构—表现”学习路径,并构建了以拆装实训平台为核心的教学体系。通过对报废扫描电镜镜筒进行可视化改良,研制了1∶1高精度可拆卸教学模型,构建了“原理认知—操作演示—实践操作”递进式课程模块。并采用多维度量化研究方法,开发了基于移动平台的交互式教学效能评估体系。基于1227份有效样本的评估结果显示:该教学体系显著提升了学生的理论知识掌握度(辅助理解认可度99.02%)、动手能力(96.98%)和创新思维(95.52%),有效克服了学生对精密设备的畏难心理(97.07%)。平台还成功支撑了多项研究生创新课题,验证了其在激发创新思维和衔接工程实践方面的优势。该研究为突破大型精密仪器教学中“认知抽象化”与“操作高风险”难题、提升材料学科人才培养质量提供了有效的解决方案和实践参考。 展开更多
关键词 扫描电镜 实验教学模式 教具 实训平台 评估体系
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13个粳稻品种生态适应性分析 认领 引用
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作者 陈盈 王志平 +5 位作者 孟野 于广星 宫殿凯 李睿 代贵金 刘宪平 《北方水稻》 CAS 2025年第3期8-11,16,共4页
以辽宁省近年新选育表现较好的13个粳稻品种为供试材料,在辽宁省海城市和盘锦市大洼区开展粳稻品种生态适应性研究。结果表明,粳99优11、辽粳1499和辽粳1540在海城试验点丰产性较好,辽粳401和粳93优3在大洼试验点丰产性较好。辽粳1499、... 以辽宁省近年新选育表现较好的13个粳稻品种为供试材料,在辽宁省海城市和盘锦市大洼区开展粳稻品种生态适应性研究。结果表明,粳99优11、辽粳1499和辽粳1540在海城试验点丰产性较好,辽粳401和粳93优3在大洼试验点丰产性较好。辽粳1499、粳99优11、辽粳1540产量变异度小,在两个试验地点产量均表现较高,适应性、丰产性和稳产性都较好。本研究为以上两个稻区水稻品种更替提供了有价值的参考,也为粳稻品种推广示范起到了借鉴作用。 展开更多
关键词 粳稻 产量 生态适应性
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750℃长期时效对FGH96粉末冶金高温合金显微组织和力学性能的影响 认领 引用
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作者 胡阳 孟野 佟瑶 《上海金属》 CAS 2025年第5期77-82,共6页
研究了750℃长期时效对FGH96粉末冶金高温合金显微组织及力学性能的影响。结果表明:随着时效时间的增加,合金中γ′强化相的平均尺寸增大,其增加幅度与时效时间呈线性关系,γ′相逐渐成为球状,三次γ′相逐渐溶解,其粗化行为符合LSW理论... 研究了750℃长期时效对FGH96粉末冶金高温合金显微组织及力学性能的影响。结果表明:随着时效时间的增加,合金中γ′强化相的平均尺寸增大,其增加幅度与时效时间呈线性关系,γ′相逐渐成为球状,三次γ′相逐渐溶解,其粗化行为符合LSW理论;γ′相的长大使其对位错运动的阻碍作用减弱。750℃长期时效后合金的抗拉强度降低、塑性提高,其主要断裂机制从沿晶断裂转变为穿晶断裂,建立了合金抗拉强度与γ′相尺寸和体积分数关系的预测模型。 展开更多
关键词 FGH96 粉末冶金高温合金 长期时效 γ′相
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Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography 认领 引用 被引量：9
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作者 Su-E Cao Lin-Qi Zhang +10 位作者 Si-Chi Kuang Wen-Qi Shi Bing Hu Si-Dong Xie Yi-Nan Chen Hui Liu Si-Min Chen Ting Jiang Meng Ye Han-Xi Zhang Jin Wang 《World Journal of Gastroenterology》 SCIE CAS 2020年第25期3660-3672,共13页
BACKGROUND The accurate classification of focal liver lesions(FLLs)is essential to properly guide treatment options and predict prognosis.Dynamic contrast-enhanced computed tomography(DCE-CT)is still the cornerstone i... BACKGROUND The accurate classification of focal liver lesions(FLLs)is essential to properly guide treatment options and predict prognosis.Dynamic contrast-enhanced computed tomography(DCE-CT)is still the cornerstone in the exact classification of FLLs due to its noninvasive nature,high scanning speed,and high-density resolution.Since their recent development,convolutional neural network-based deep learning techniques has been recognized to have high potential for image recognition tasks.AIM To develop and evaluate an automated multiphase convolutional dense network(MP-CDN)to classify FLLs on multiphase CT.METHODS A total of 517 FLLs scanned on a 320-detector CT scanner using a four-phase DCECT imaging protocol(including precontrast phase,arterial phase,portal venous phase,and delayed phase)from 2012 to 2017 were retrospectively enrolled.FLLs were classified into four categories:Category A,hepatocellular carcinoma(HCC);category B,liver metastases;category C,benign non-inflammatory FLLs including hemangiomas,focal nodular hyperplasias and adenomas;and category D,hepatic abscesses.Each category was split into a training set and test set in an approximate 8:2 ratio.An MP-CDN classifier with a sequential input of the fourphase CT images was developed to automatically classify FLLs.The classification performance of the model was evaluated on the test set;the accuracy and specificity were calculated from the confusion matrix,and the area under the receiver operating characteristic curve(AUC)was calculated from the SoftMax probability outputted from the last layer of the MP-CDN.RESULTS A total of 410 FLLs were used for training and 107 FLLs were used for testing.The mean classification accuracy of the test set was 81.3%(87/107).The accuracy/specificity of distinguishing each category from the others were 0.916/0.964,0.925/0.905,0.860/0.918,and 0.925/0.963 for HCC,metastases,benign non-inflammatory FLLs,and abscesses on the test set,respectively.The AUC(95%confidence interval)for differentiating each category from the others was 0.92(0.837-0.992),0.99(0.967-1.00),0.88(0.795-0.955)and 0.96(0.914-0.996)for HCC,metastases,benign non-inflammatory FLLs,and abscesses on the test set,respectively.CONCLUSION MP-CDN accurately classified FLLs detected on four-phase CT as HCC,metastases,benign non-inflammatory FLLs and hepatic abscesses and may assist radiologists in identifying the different types of FLLs. 展开更多
关键词 Deep learning Convolutional neural networks Focal liver lesions Classification Multiphase computed tomography Dynamic enhancement pattern
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Relationship Between Grain Boundary Segregation of Antimony and Temper Embrittlement in Titanium-Doped Nickel-Chromium Steel 认领 引用 被引量：5
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作者 ZHENG Lei ZHANG Mai-cang +1 位作者 DONG Jian-xin MENG Ye 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2011年第1期68-72,共5页
The antimony segregation at grain boundary was observed and the temper embrittlement in titanium-doped nickel-chromium steel was analyzed.It is concluded that the antimony segregation at grain boundary is nonequilibiu... The antimony segregation at grain boundary was observed and the temper embrittlement in titanium-doped nickel-chromium steel was analyzed.It is concluded that the antimony segregation at grain boundary is nonequilibium and the kinetics of temper embrittlement agrees well with those of nonequilibrium antimony segregation at grain boundary.Besides,the mechanism of nonequilibrium antimony segregation at grain boundary proved to be the most satisfactory one among the existing mechanisms to interpret the antimony induced embrittlement kinetics in the nick-el-chromiunl steel.Based on these,the activation energy and frequency factor of diffusion of antimony vacancy complexes were obtained according to the concept of critical time in nonequilibrium grain boundary segregation theory. 展开更多
关键词 grain boundary segregation temper embrittlement critical time diffusion activation energy
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A constitutive serine protease inhibitor suppresses herbivore performance in tea(Camellia sinensis) 认领 引用 被引量：4
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作者 Meng Ye Chuande Liu +5 位作者 Nana Li Chenhong Yuan Miaomiao Liu Zhaojun Xin Shu Lei Xiaoling Sun 《Horticulture Research》 SCIE CSCD 2023年第10期112-122,共11页
Protease inhibitors promote herbivore resistance in diverse plant species.Although many inducible protease inhibitors have been identified,there are limited reports available on the biological relevance and molecular ... Protease inhibitors promote herbivore resistance in diverse plant species.Although many inducible protease inhibitors have been identified,there are limited reports available on the biological relevance and molecular basis of constitutive protease inhibitors in herbivore resistance.Here,we identified a serine protease inhibitor,CsSERPIN1,from the tea plant(Camellia sinensis).Expression of CsSERPIN1 was not strongly affected by the assessed biotic and abiotic stresses.In vitro and in vivo experiments showed that CsSERPIN1 strongly inhibited the activities of digestive protease activities of trypsin and chymotrypsin.Transient or heterologous expression of CsSERPIN1 significantly reduced herbivory by two destructive herbivores,the tea geometrid and fall armyworm,in tea and Arabidopsis plants,respectively.The expression of CsSERPIN1 in Arabidopsis did not negatively influence the growth of the plants under the measured parameters.Our findings suggest that CsSERPIN1 can inactivate gut digestive proteases and suppress the growth and development of herbivores,making it a promising candidate for pest prevention in agriculture. 展开更多
关键词 protease Arabidopsis Camellia
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A novel inhibitor of the jasmonic acid signaling pathway represses herbivore resistance in tea plants 认领 引用 被引量：2
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作者 Songbo Lin Meng Ye +4 位作者 Xiwang Li Yuxian Xing Miaomiao Liu Jin Zhang Xiaoling Sun 《Horticulture Research》 SCIE CSCD 2022年第1期203-212,共10页
The jasmonic acid(JA)signaling pathway plays a vital role in mediating plant resistance to herbivores.The tea plant(Camellia sinensis)is one of the most important woody cash crops in the world.Due to the lack of genet... The jasmonic acid(JA)signaling pathway plays a vital role in mediating plant resistance to herbivores.The tea plant(Camellia sinensis)is one of the most important woody cash crops in the world.Due to the lack of genetic transformation systems for tea plants,how the JA signaling pathway works in tea plants has not yet been determined.Now,with the development of cross-disciplines,chemical biology provides new means for analyzing the JA signaling pathway.In the present study,the structure of the small-molecule isoquinoline compound ZINC71820901(lyn3)was obtained from the ZINC molecular library through virtual screening based on the structure of the crystal COI1-JAZ1 co-receptor andwas found to act as an inhibitor of the JA signaling pathway in both Arabidopsis and tea plants.Our results revealed that lyn3 repressed tea plant resistance to Ectropis grisescens mainly by decreasing the accumulation of(-)-epicatechin and(-)-epigallocatechin via repression of the JA signaling pathway,which functioned in a modulation manner different from that of the already known inhibitor salicylhydroxamic acid(SHAM).As a novel inhibitor of the JA signaling pathway,lyn3 provides a specific option for further research on the JA pathway. 展开更多
关键词 ja signaling pathway mediating plant resistance herbivoresthe herbivore resistance woody cash crops jasmonic acid signaling pathway tea plants genetic transformation systems chemical biology
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Gas-phase and particle-phase PCDD/F congener distributions in the flue gas from an iron ore sintering plant 认领 引用 被引量：13
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作者 Xiaolong Liu Meng Ye +2 位作者 Xue Wang Wen Liu Tingyu Zhu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2017年第4期239-245,共7页
The activated carbon injection-circulating fluidized bed（ACI-CFB）-bag filter coupling technique was studied in an iron ore sintering plant. For comparison, the removal efficiencies under the conditions without or wi... The activated carbon injection-circulating fluidized bed（ACI-CFB）-bag filter coupling technique was studied in an iron ore sintering plant. For comparison, the removal efficiencies under the conditions without or with ACI technology were both evaluated. It was found that the polychlorinated dibenzo-p-dioxins and dibenzofuran（PCDD/F） removal efficiency for total international toxic equivalence quantity（I-TEQ） concentration was improved from 91.61% to 97.36% when ACI was employed, revealing that ACI was very conducive to further controlling the PCDD/F emissions. Detailed congener distributions of PCDD/Fs in the gas-phase and particle-phase of the Inlet and Outlet samples were determined. Additionally, the PCDD/F distribution for the Fly ash-with ACI sample of was also studied. 展开更多
关键词 PCDD/Fs Congener distribution Iron ore sintering plant Flue gas Fly ash
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Vitamin C Inhibits Benzo[a]pyrene-Induced Cell Cycle Changes Partly via Cyclin D1/E2F Pathway in Human Embryo Lung Fibroblasts 认领 引用 被引量：1
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作者 AI GAO BING-CI LIU +6 位作者 XIANG-LIN SHI CHUAN-SHU HUANG XIAO-WEI JIA BAO-RONG YOU MENG YE FU-HAI SHEN HONG-JU DU 《Biomedical and Environmental Sciences》 SCIE CAS 2006年第3期239-244,共6页
Objective To study the molecular mechanism of the inhibitory effects of vitamin C on benzo[a]pyrene （B[a]P）-induced changes of cell cycle in human embryo lung fibroblast （HELF） cells. Methods The stable transfecta... Objective To study the molecular mechanism of the inhibitory effects of vitamin C on benzo[a]pyrene （B[a]P）-induced changes of cell cycle in human embryo lung fibroblast （HELF） cells. Methods The stable transfectants, HELF transfected with antisense cyclin D1 and antisense CDK4, were established. Cells were cultured and pretreated with vitamin C before stimulation with B[a]P for 24 h. The expression levels of cyclin DI, CDK4, E2FI, and E2F4 were determined by Western blot. Flow cytometric analysis was employed to detect the distributions of cell cycle. Results B[a]P significantly elevated the expression levels of cyclin D 1, E2F1, and E2F4 in HELF cells. Vitamin C decreased the expression levels of cyclin D 1, E2F1, and E2F4 in B [a]P-stimulated HELF cells. Dose-dependent relationships were not found between the different concentrations of vitamin C （10, 100, 500, 1000, and 5000 lamol/L） and the expression levels of cyclin D 1, E2F1, and E2F4 in HELF cells. The expression levels of cyclin D1, E2FI, and E2F4 in B[a]P-treated transfectants were lower than those in B[a]P-treated HELF cells. The expression levels of cyclin DI and E2F4 treated with vitamin C and antisense cyclin D1 were decreased compared with those treated with antisense cyclin DI alone. The effects of vitamin C combined with antisense CDK4 on the expression levels of cyclin DI and E2FI/E2F4 were similar to those of antisense CDK4 alone. B[a]P progressed HELF cells from GI to S phase. Both vitamin C and antisense cyclin DI suppressed the changes of cell cycle progressed by B[a]P. However, antisense CDK4 did not attenuate the above changes. Vitamin C combined with antisense CDK4 markedly suppressed B[a]P-induced changes of cell cycle as compared with antisense CDK4. But the inhibitory effects of vitamin C combined with antisense cyclin DI on B[a]P-induced changes of cell cycle were similar to those of vitamin C alone or antisense cyclin DI alone. Conclusions B[a]P progressed HELF cells from G1 to S phase via intracellular signaling pathway of cyclin D I/E2F. Vitamin C may modulate this signaling pathway to protect cells from injury caused by B[a]P. 展开更多
关键词 B[a]P Ascorbic acid Cyclin D1 E2F Cell cycle Antisense
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Different Patterns of Cyclin D1/CDK4-E2F-1/4 Pathways in Human Embryo Lung Fibroblasts Treated by Benzo[a]pyrene at Different Doses 认领 引用 被引量：1
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作者 MENG YE BING-CI LIU +4 位作者 XIANG-LIN SHI BAO-RONG YOU HONG-JU DU XIAO-WEI JIA FU-HAI SHEN 《Biomedical and Environmental Sciences》 SCIE CAS 2008年第1期30-36,共7页
Objective To investigate the roles of the cyclin D1/CDK4 and E2F-1/4 pathways and compare their work patterns in cell cycle changes induced by different doses of B[a]E Methods Human embryo lung fibroblasts （HELFs） w... Objective To investigate the roles of the cyclin D1/CDK4 and E2F-1/4 pathways and compare their work patterns in cell cycle changes induced by different doses of B[a]E Methods Human embryo lung fibroblasts （HELFs） were treated with 2 μmol/L or 100 μmol/L B[a]P which were provided with some characteristics of transformed cells （T-HELFs）. Cyclin D l, CDK4 and E2F-1/4 expressions were determined by Western blotting. Flow cytometry was used to detect the distribution of cell cycle. Results After B[a]P treatment, the proportion of the first gap （G 1） phase cells decreased. CDK4 and E2F-4 expression did not change significantly. In 2 μmol/L treated cells, a marked overexpression of cyclin D1 and E2F-1 was observed. However, in T-HELFs overexpression was limited to cyclin D1 only, and no overexpression of E2F-1 was observed. The decreases of G1 phase in response to B[a]P treatment were blocked in antisense cyclin D1 and antisense CDK4 transfected HELFs （A-D1 and A-K4） and T-HELFs （T-A-D1 and T-A-K4）. After 2 μmol/L B[a]P treatment, overexpression of E2F-1 was attenuated in A-D1, and E2F-4 expression was decreased significantly in A-K4. In T-A-D1 and T-A-K4, E2F-4 expression was increased significantly, compared with T-HELFs. The E2F-1 expression remained unchanged in T-A-D1 and T-A-K4. Condusions Cyclin DI/CDK4-E2F-1/4 pathways work in different patterns in response to low dose and high dose B[a]P treatment. In HELFs treated with 2 μmol/L B[a]P, cyclin D1 positively regulates the E2F-1 expression while CDK4 negatively regulates the E2F-4 expression; however, in HELFs treated with 100 μmol/L B[a]P, both cyclin D1 and CDK4 negatively regulate the E2F-4 expression. 展开更多
关键词 Benzo[a]pyrene Cyclin D1 CDK4 E2F Cell cycle
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Acute exacerbation of chronic obstructive pulmonary disease was associated with respiratory syncytial virus infection and the upregulation of TLR3 认领 引用 被引量：1
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作者 LING GONG HUAJUN YANG +5 位作者 YING HUANG ZHU LI JIN NIE MENG YE PENG XIE DAISHUN LIU 《BIOCELL》 SCIE 2022年第4期1025-1032,共8页
Respiratory syncytial virus(RSV)infection is known as a risk factor for chronic obstructive pulmonary disease(COPD).RSV infection induces the upregulation of Toll-like receptor 3(TLR3).This study aimed to investigate ... Respiratory syncytial virus(RSV)infection is known as a risk factor for chronic obstructive pulmonary disease(COPD).RSV infection induces the upregulation of Toll-like receptor 3(TLR3).This study aimed to investigate the association of TLR3 with RSV induced acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Serum/sputum samples from AECOPD patients,stable chronic obstructive pulmonary disease(SCOPD)patients,and healthy controls were collected.Nested PCR was used to detect RSV.The lung function parameters were assessed by blood gas and lung function analysis.The expression levels of inflammatory factors in sputum and serum samples were determined by enzyme-linked immunosorbent assay.BEAS-2B cell lines were infected with RSV,and the expression of TLR3 mRNA was determined by PCR and the levels of inflammatory factors were also investigated.The presence of RSV was detected in 3 SCOPD and 8 AECOPD patients,but not in healthy patients.The expression levels of TNF-αand IRF-3 in both sputum and serum samples of RSV-positive group were significantly higher than in RSV-negative group.TLR3 mRNA levels in RSV-positive group were significantly higher than those in RSVnegative group.Interestingly,the level of TLR3 mRNA expression was negatively correlated with oxygenation index and lung function parameters.Furthermore,BEAS-2B cells infected with RSV led to significant increase of the expression of TLR3 mRNA and inflammatory factors IFN-β,IL-13,IL-32,and TNF-α.Our observations indicate that AECOPD is associated with RSV infection and the upregulation of TLR3. 展开更多
关键词 TLR3 Chronic obstructive pulmonary disease RSV Inflammation
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Multi-Scale Image Segmentation Model for Fine-Grained Recognition of Zanthoxylum Rust 认领 引用 被引量：1
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作者 Fan Yang Jie Xu +5 位作者 Haoliang Wei Meng Ye Mingzhu Xu Qiuru Fu Lingfei Ren Zhengwen Huang 《Computers, Materials & Continua》 SCIE EI 2022年第5期2963-2980,共18页
Zanthoxylum bungeanum Maxim,generally called prickly ash,is widely grown in China.Zanthoxylum rust is the main disease affecting the growth and quality of Zanthoxylum.Traditional method for recognizing the degree of i... Zanthoxylum bungeanum Maxim,generally called prickly ash,is widely grown in China.Zanthoxylum rust is the main disease affecting the growth and quality of Zanthoxylum.Traditional method for recognizing the degree of infection of Zanthoxylum rust mainly rely on manual experience.Due to the complex colors and shapes of rust areas,the accuracy of manual recognition is low and difficult to be quantified.In recent years,the application of artificial intelligence technology in the agricultural field has gradually increased.In this paper,based on the DeepLabV2 model,we proposed a Zanthoxylum rust image segmentation model based on the FASPP module and enhanced features of rust areas.This paper constructed a fine-grained Zanthoxylum rust image dataset.In this dataset,the Zanthoxylum rust image was segmented and labeled according to leaves,spore piles,and brown lesions.The experimental results showed that the Zanthoxylum rust image segmentation method proposed in this paper was effective.The segmentation accuracy rates of leaves,spore piles and brown lesions reached 99.66%,85.16%and 82.47%respectively.MPA reached 91.80%,and MIoU reached 84.99%.At the same time,the proposed image segmentation model also had good efficiency,which can process 22 images per minute.This article provides an intelligent method for efficiently and accurately recognizing the degree of infection of Zanthoxylum rust. 展开更多
关键词 Zanthoxylum rust image segmentation deep learning
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Negative Differential Resistance and Rectifying Effects of Diblock Co-Oligomer Molecule Devices Sandwiched between C_2N-h2D Electrodes 认领 引用 被引量：1
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作者 Meng Ye Cai-Juan Xia +1 位作者 Bo-Qun Zhang Yue Ma 《Chinese Physics Letters》 SCIE EI CAS CSCD 2019年第4期75-78,共4页
Based on nonequilibrium Green's function method in combination with density functional theory, we study the electronic transport properties of dipyrimidinyl-diphenyl molecules embedded in a carbon atomic chain san... Based on nonequilibrium Green's function method in combination with density functional theory, we study the electronic transport properties of dipyrimidinyl-diphenyl molecules embedded in a carbon atomic chain sandwiched between zigzag graphene nanoribbon and different edge geometries C_2N-h2D electrodes. Compared with the graphene electrodes, the C_2N-h2D electrode can cause rectifying and negative differential resistance effects.For C_2N-h2D with zigzag edges, a more remarkable negative differential resistance phenomenon appears, whereas armchair-edged C_2N-h2D can give rise to much better rectifying behavior. These results suggest that this system can be potentially useful for designs of logic and memory devices. 展开更多
关键词 nonequilibrium system memory
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Magnesium Demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress 认领 引用
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作者 XINTING ZHU MENG YE +6 位作者 KELAN FANG FANG LIU JING HUI MEICHEN LIU XIAOFEI LI RONG YAN YUN LIU 《BIOCELL》 SCIE 2022年第12期2595-2600,共6页
Cantharidin(CTD)is a bioactive ingredient isolated from Cantharis vesicatoria(blister beetles),which has potential therapeutic value as an anticancer agent.Magnesium Demethylcantharidate(MDC)is a recently developed de... Cantharidin(CTD)is a bioactive ingredient isolated from Cantharis vesicatoria(blister beetles),which has potential therapeutic value as an anticancer agent.Magnesium Demethylcantharidate(MDC)is a recently developed derivative of Cantharidin(CTD),and previous studies have illustrated its excellent anticancer activity on HCC cells.However,the effect and mechanism of MDC remains unclear and need to be further studied.In particular,whether MDC can cause ER stress in HCC is still unknown.In this study,we demonstrated that endoplasmic reticulum stress(ERS)-related proteins were changed in SMMC-7721 and Bel-7402 cells after being exposed to MDC.Moreover,we found that MDC could significantly inhibit the growth of xenograft tumor in nude mice.In summary,we confirmed that MDC could induce ERS in HCC cells and thus induce apoptosis. 展开更多
关键词 Magnesium Demethylcantharidate Hepatocellular carcinoma ER stress Apoptosis
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