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Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy 认领 引用 被引量：3
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作者 Qi-qi WANGI Ming-xue LI +4 位作者 Chen LI Xiao-xia GU Meng-zhu ZHENG Li-xia CHEN Hua LI 《Current Medical Science》 SCIE CAS 2020年第2期205-217,共13页
In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintai... In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared. 展开更多
关键词 cancer energy metabolism cancer therapy natural products binding targets,inhibitors
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Copolymers with fluorescence properties in mesoporous silica SBA-15:Synthesis and characterization 认领 引用 被引量：3
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作者 Li-Ping Wang Guang Li +7 位作者 Wen-Zhi Li Chao-Lei Ban Yu-Chao Li Cong Guo Meng-Meng Zhang Ling-Yun Liu Na-Na Lu Meng-Zhu Zheng 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第12期1620-1624,共5页
A novel copolymer with fluorescence properties in mesoporous silica SBA-15 was prepared via a combination of surface-initiated reversible addition-fragmentation chain transfer（RAFT） polymerization and ＂click＂ chem... A novel copolymer with fluorescence properties in mesoporous silica SBA-15 was prepared via a combination of surface-initiated reversible addition-fragmentation chain transfer（RAFT） polymerization and ＂click＂ chemistry.A sufficient amount of peroxide groups were introduced into mesoporous silica SBA-15 channel pores and were further used to initiate the RAFT polymerization of styrene and 4-vinylbenzyl azide,resulting in SBA-15 supported polystyrene-co-poly（4-vinylbenzyl azide） copolymer（PS-co-PVBA/SBA-15） hybrid material.The samples were characterized by Fourier transform infrared spectroscopy（FT-IR）,transmission electron microscopy（TEM）,thermogravimetry analysis（TGA）,N_2 adsorption-desorption isotherms and X-ray diffraction（XRD）,respectively.The results show that the styrene and 4-vinylbenzyl azide had copolymerized inside mesoporous silica SBA-15.Subsequently,Npropargyl-carbazole（PC） was connected to PS-co-PVBA/SBA-15 hybrid material via ＂click＂ reaction,resulting in PS-co-PVBC/SBA-15 with carbazole side groups hybrid material.The fluorescence spectrum is dominated by a broad band from 350 nm to 400 nm in narrow region and the maximum peak is 362 nm,indicating the characteristic absorption of the carbazole group of PS-co-PVBC/SBA-15 hybrid material. 展开更多
关键词 SBA-15 RAFT ＂Click＂ chemistry Fluorescence properties
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Therapeutic Effects and Mechanisms of Baikudong Decoction in Colorectal Cancer:Insights from Network Pharmacology and Experimental Validation 认领 引用
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作者 Ning Ding Meng-Zhu Zheng +7 位作者 Abudureyimujiang Aili Ran Peng Zhan-Qun Yang Yi-Heng Yang Cheng-He Shi Hao Wang Long Chen Jian Lin 《World Journal of Traditional Chinese Medicine》 CAS CSCD 2025年第4期547-558,共12页
Objective:This study investigated the mechanisms and efficacy of baikudong decoction(BKD)in colorectal cancer(CRC).Preliminary clinical validation suggests that BKD may reduce serum levels of tumor markers in cancer p... Objective:This study investigated the mechanisms and efficacy of baikudong decoction(BKD)in colorectal cancer(CRC).Preliminary clinical validation suggests that BKD may reduce serum levels of tumor markers in cancer patients.Materials and Methods:Network pharmacology analysis identified 195 active compounds in BKD,corresponding to 610 potential gene targets,of which 301 were highly relevant to CRC.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses highlighted several apoptosis-related pathways.In vitro and in vivo experiments,including cell proliferation and migration assays,flow cytometry,western blot analysis,and mouse xenograft models,were conducted to validate the efficacy and mechanism of BKD.Results:Both in vitro and in vivo studies confirmed that BKD induced apoptosis in CRC cells by activating caspase-3,inhibited cancer cell proliferation and migration,and exhibited anti-CRC activity.Clinically,33.33%of nine patients with CRC treated with BKD achieved a pathological complete response.Conclusions:BKD is effective in treating CRC through the induction of cancer cell apoptosis.The study demonstrated its efficacy in both mouse xenograft models and preliminary clinical practice. 展开更多
关键词 Apoptosis baikudong decoction clinical practice colorectal cancer network pharmacology
Progress of Traditional Chinese Medicine Treating COVID-19 认领 引用 被引量：2
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作者 Ming-Xue Li Yue-Ying Yang +4 位作者 Yang Liu Meng-Zhu Zheng Jun Li Li-Xia Chen Hua Li 《World Journal of Traditional Chinese Medicine》 CAS CSCD 2021年第2期167-183,共17页
The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and fatigue.The emergenc... The new coronavirus pneumonia(coronavirus disease 2019[COVID-19]),caused by the new coronavirus(severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]),mainly manifests by fever,dry cough,and fatigue.The emergence of SARS-CoV-2 poses a huge threat to people’s lives.Unfortunately,so far,there are no effective treatment drugs and vaccines.Traditional Chinese medicine(TCM)has played an important role and achieved good results for treating this epidemic.More than 85%of patients with SARS-CoV-2 infection in China have received TCM treatment.In this article,we describe the progress of TCM for the COVID-19 therapy. 展开更多
关键词 Chinese patent medicines coronavirus disease 2019 decoctions traditional Chinese medicine
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