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COAP-Pd Catalyzed Asymmetric Ring-Opening Allylic Alkylation for Linear Unsaturated Quaternary Amino Acid Derivatives 认领 引用
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作者 Yan-Qi Ma Min Chen +3 位作者 Chuan Wang Huang-Jie Zhou Jia-Li Zhang Xing-Wang Wang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2026年第11期1835-1843,共9页
Unsaturated quaternary amino acids are essential building blocks for the construction of non‑natural peptides and proteins.Herein,ring‑opening allylic alkylation between vinyl(hetero)cyclopropanes and 4‑substituted az... Unsaturated quaternary amino acids are essential building blocks for the construction of non‑natural peptides and proteins.Herein,ring‑opening allylic alkylation between vinyl(hetero)cyclopropanes and 4‑substituted azlactones was developed,which was catalyzed by our designed COAP‑Pd complexes.Several series ofγ,δ‑unsaturated quaternary amino acid derivatives were obtained in good yields with high regio‑and enantioselectivity.The transformations exhibited good tolerance toward a variety of azlactone substrates,enabling the efficient synthesis of a diverse library of chiralγ,δ‑unsaturated quaternary amino acid derivatives with functional allylic side chains.The synthetic utility of this protocol was validated through gram‑scale reactions and subsequent functional group transformations,including hydrolysis under acidic condition to afford non‑natural quaternary amino acids,alcoholysis under basic conditions to give quaternary amino acid esters,as well as epoxidation of the pendent alkenyl groups.In addition,the chiral 4,5‑dihydrooxazole scaffolds with potential pharmaceutical value were also constructed via further cyclization of the corresponding quaternary amino alcohol derivatives,which were prepared from reductive ring‑opening of the corresponding azlactone moieties in the presence of reducing reagents.Moreover,the coordination models and the active catalytic species were further deduced by X‑ray crystallographic analysis and(31)^P NMR experiments.Notably,the resultingγ,δ‑unsaturated quaternary amino acid derivatives featured unique linear side chains and quaternary carbon centers.And that,the linear allylic side chains held the promise as a linkage for modifying drugs and natural products,as it allowed for the conjugation of two bioactive scaffolds. 展开更多
关键词 Asymmetric catalysis Ring‑opening allylic alkylation Non‑natural amino acid Functional allylic side chains Enantioselectivity γ,δ‑Unsaturated quaternary amino acid COAP‑Pd catalysis Chirality
Effects of allelochemicals from plants on seed germination 认领 引用 被引量：2
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作者 Zhi-Yao Wang Kai-Long Yan +3 位作者 Yi-Ming Qin Nai-Chao Zhang Xiao-Chao Chen Min Chen 《Seed Biology》 2025年第1期38-47,共10页
Seed germination is a pivotal stage in the plant life cycle,profoundly influenced by allelochemicals—biologically active compounds released by plants into the environment.These compounds can either suppress or stimul... Seed germination is a pivotal stage in the plant life cycle,profoundly influenced by allelochemicals—biologically active compounds released by plants into the environment.These compounds can either suppress or stimulate germination,thereby shaping agricultural productivity and ecological dynamics.However,research on plant-derived allelochemicals faces significant challenges,including their structural diversity,low natural abundance,and methodological limitations in isolation/characterization.Furthermore,the precise mechanisms through which these compounds modulate seed germination are not yet well understood.Elucidating these processes is crucial for deciphering the chemical ecology of plant–plant interactions,optimizing agricultural practices,and guiding ecological restoration efforts.This review synthesizes current knowledge on the structural classes and natural sources of allelochemicals,their roles in germination regulation,emerging analytical techniques for their study,and their potential applications in sustainable agriculture. 展开更多
关键词 allelochemicals biologically active compounds plant plant interactions chemical ecology seed germination allelochemicals stimulate germinationthereby sustainable agriculture
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Ring-opening Metathesis Polymerization to Access Degradable Iminebased Polymers 认领 引用 被引量：1
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作者 Wu Li Si-Jia Cheng +2 位作者 You-Gui Li Muhammad Asadullah Khan Min Chen 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第6期908-913,I0006,共6页
As a powerful synthetic tool,ruthenium-catalyzed ring-opening metathesis polymerization(ROMP)has been widely utilized to prepare diverse heteroatom-containing polymers.In this contribution,we report the synthesis of t... As a powerful synthetic tool,ruthenium-catalyzed ring-opening metathesis polymerization(ROMP)has been widely utilized to prepare diverse heteroatom-containing polymers.In this contribution,we report the synthesis of the novel imine-based polymer through the copolymerization of cyclooctene with cyclic imine comonomer via ROMP.Because of the efficient hydrolysis reactions of the imine group,the generated copolymer can be easily degraded under mild condition.Moreover,the generated degradable product was the telechelic polymer bearing amine group,which was highly challenged for its direct synthesis.And this telechelic polymer could also be used for the further synthesis of new polymer through post-transformation.The introduction of imine unit in this work provides a new example of the degradable polymer synthesis. 展开更多
关键词 Degradable polymer Ring-opening metathesis polymerization Imine-based polymer Copolymerization
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Male juvenile golden snub-nosed monkeys acting as the mountee to receive grooming in their same-sex mounts 认领 引用
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作者 Pengzhen Huang Julie A.Teichroeb +1 位作者 Endi Zhang Min Chen 《Current Zoology》 SCIE CAS CSCD 2025年第1期40-48,共9页
Same-sex mounts provide male juvenile golden snub-nosed monkeys(Rhinopithecus roxellana)with opportunities to practice heterosexual copulatory skills and are often followed by grooming(post-mounting grooming,PMG).We h... Same-sex mounts provide male juvenile golden snub-nosed monkeys(Rhinopithecus roxellana)with opportunities to practice heterosexual copulatory skills and are often followed by grooming(post-mounting grooming,PMG).We hypothesized that juveniles acted as the mountee and provided mounting opportunities to receive grooming from their peer mounter.Here,we observed same-sex mounts among male juveniles(N=5)in a captive group of R.roxellana in Shanghai Wild Animal Park,China,from November 2014 to June 2015.Among 1,044 mounts recorded,45.40% were accompanied by PMG initiated by the mounter and only 3.74% were followed by PMG initiated by the mountee.Mountees were more likely to receive PMG when they performed a mounting solicitation than when they did not,or when they were mounted for a longer time(even if they did not solicit).Over a long timeframe(1 month),mountee’s tended to choose partners who groomed them more often than others after mounting,regardless of how long the grooming lasted.However,whether the mounter groomed the mountee did not predict the mounting direction in their subsequent mount.Our results suggest that,in the context of same-sex mounts,juveniles provide mounting opportunities to receive grooming from peers on a long-term,rather than on a short-term basis.This study provides the first evidence that juveniles’same-sex mounting strategy may be associated with the grooming market in nonhuman primates,which necessitates further investigation with large free-ranging groups due to the limited sample size of individuals and the captive setting of the current study. 展开更多
关键词 biological markets cooperation needing-to-learn hypothesis partner choice post-mounting groom same-sex mount
Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats 认领 引用 被引量：2
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作者 Chunge Ren Min Chen +10 位作者 Bangqi Ren Yuxiao Zeng Qiang Tan Qiyou Li Xue Zhang Yajie Fang Yixiao Zhou Weitao Zhang Fang Chen Baishijiao Bian Yong Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期821-832,共12页
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplanta... Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells alone.Bone marrow mesenchymal stem cells regulate and interact with various cells in the retinal microenvironment by secreting neurotrophic factors and extracellular vesicles.Small extracellular vesicles derived from bone marrow mesenchymal stem cells,which offer low immunogenicity,minimal tumorigenic risk,and ease of transportation,have been utilized in the treatment of various neurological diseases.These vesicles exhibit various activities,including anti-inflammatory actions,promotion of tissue repair,and immune regulation.Therefore,novel strategies using human retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles may represent an innovation in stem cell therapy for retinal degeneration.In this study,we developed such an approach utilizing retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles to treat retinal degeneration in Royal College of Surgeons rats,a genetic model of retinal degeneration.Our findings revealed that the combination of bone marrow mesenchymal stem cell-derived small extracellular vesicles and retinal progenitor cells significantly improved visual function in these rats.The addition of bone marrow mesenchymal stem cell-derived small extracellular vesicles as adjuvants to stem cell transplantation with retinal progenitor cells enhanced the survival,migration,and differentiation of the exogenous retinal progenitor cells.Concurrently,these small extracellular vesicles inhibited the activation of regional microglia,promoted the migration of transplanted retinal progenitor cells to the inner nuclear layer of the retina,and facilitated their differentiation into photoreceptors and bipolar cells.These findings suggest that bone marrow mesenchymal stem cell-derived small extracellular vesicles potentiate the therapeutic efficacy of retinal progenitor cells in retinal degeneration by promoting their survival and differentiation. 展开更多
关键词 differentiation inflammation mesenchymal stem cells microglia migration rat retinal degeneration retinal progenitor cells small extracellular vesicles stem cell transplantation
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Low-density lipoprotein receptor–related protein 1 mediatesα-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease 认领 引用 被引量：1
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作者 Hanjiang Luo Caixia Peng +5 位作者 Chengli Wu Chengwei Liu Qinghua Li Shun Yu Jia Liu Min Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1595-1606,共12页
α-Synuclein accumulation and transmission are vital to the pathogenesis of Parkinson's disease,although the mechanisms underlying misfoldedα-synuclein accumulation and propagation have not been conclusively dete... α-Synuclein accumulation and transmission are vital to the pathogenesis of Parkinson's disease,although the mechanisms underlying misfoldedα-synuclein accumulation and propagation have not been conclusively determined.The expression of low-density lipoprotein receptor–related protein 1,which is abundantly expressed in neurons and considered to be a multifunctional endocytic receptor,is elevated in the neurons of patients with Parkinson's disease.However,whether there is a direct link between low-density lipoprotein receptor–related protein 1 andα-synuclein aggregation and propagation in Parkinson's disease remains unclear.Here,we established animal models of Parkinson's disease by inoculating monkeys and mice withα-synuclein pre-formed fibrils and observed elevated low-density lipoprotein receptor–related protein 1 levels in the striatum and substantia nigra,accompanied by dopaminergic neuron loss and increasedα-synuclein levels.However,low-density lipoprotein receptor–related protein 1 knockdown efficiently rescued dopaminergic neurodegeneration and inhibited the increase inα-synuclein levels in the nigrostriatal system.In HEK293A cells overexpressingα-synuclein fragments,low-density lipoprotein receptor–related protein 1 levels were upregulated only when the N-terminus ofα-synuclein was present,whereas anα-synuclein fragment lacking the N-terminus did not lead to low-density lipoprotein receptor–related protein 1 upregulation.Furthermore,the N-terminus ofα-synuclein was found to be rich in lysine residues,and blocking lysine residues in PC12 cells treated withα-synuclein pre-formed fibrils effectively reduced the elevated low-density lipoprotein receptor–related protein 1 andα-synuclein levels.These findings indicate that low-density lipoprotein receptor–related protein 1 regulates pathological transmission ofα-synuclein from the striatum to the substantia nigra in the nigrostriatal system via lysine residues in theα-synuclein N-terminus. 展开更多
关键词 α-synuclein dopaminergic neurodegeneration internalization low-density lipoprotein receptor-related protein 1 lysine pre-formed fibril movement disorder nigrostriatal system Parkinson's disease transmission
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Identification of a novel HIV-1 circulating recombinant form(CRF161_0107)from CRF01_AE-C5 lineage among men who have sex with men in southwestern China 认领 引用
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作者 Min Chen Huichao Chen +2 位作者 Yanling Ma Manhong Jia Wenfei Ding 《Virologica Sinica》 SCIE CAS CSCD 2026年第2期470-473,共4页
Dear Editor,The ongoing emergence of circulating recombinant forms(CRFs)of HIV-1 was recently reported among men who have sex with men(MSM)in China(Xiao et al.,2025;Xing et al.,2024).HIV-1’s global diversity is class... Dear Editor,The ongoing emergence of circulating recombinant forms(CRFs)of HIV-1 was recently reported among men who have sex with men(MSM)in China(Xiao et al.,2025;Xing et al.,2024).HIV-1’s global diversity is classified into four groups:M(Major,causing the pandemic),O(Outlier),N,and P.Group M,the most prevalent,is subdivided into subtypes(A-D,F-H and J-L).Recombinant viruses formed between subtypes are classified as either stable CRFs spreading in populations or unique recombinant forms(URFs).HIV-1 recombination significantly complicates HIV genetics and has the capacity to directly alter key viral properties. 展开更多
关键词 HIV southwestern China circulating recombinant forms crfs men who sex CRF unique recombinant forms urfs hiv circulating recombinant forms CRF AE C lineage
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Interface-morphology synergy in TiN nanotube-supported Pt catalyst layers enables durable proton-exchange-membrane fuel cells 认领 引用
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作者 Min Chen Yu Zhou +4 位作者 Peng Rao Xinlong Tian Ruisong Li Jing Li Zhengpei Miao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期425-430,共6页
The stability of cathode catalyst layers(CCLs)in proton exchange membrane fuel cells(PEMFCs)is critically undermined by Pt dissolution and the loss of effective gas-water management associated with carbon support corr... The stability of cathode catalyst layers(CCLs)in proton exchange membrane fuel cells(PEMFCs)is critically undermined by Pt dissolution and the loss of effective gas-water management associated with carbon support corrosion.In this work,we develop a porous TiN nanotube-supported Pt(i.e.,Pt/TiN NTs)CCL that integrates robust Pt-Ti interfacial bonding with a highly accessible nanotube network to address these persistent challenges.The formation of abundant Pt-Ti bonds at the interface markedly strengthens Pt anchoring,resulting in a 2.3-fold reduction in Pt dissolution and minimal particle coarsening after accelerated durability testing compared to nanoflows-based controls dominated by Pt-N-Ti interactions.The membrane electrode assembly fabricated with this CCL achieves a peak power density of 0.81 W/cm2 and demonstrates exceptional durability,retaining 77%of its initial mass activity and 87.3%of its power density following aggressive square-wave potential cycling,meeting the 2025 U.S.Department of Energy benchmarks.Computational fluid dynamics simulation further reveal that the unique porous architecture facilitates efficient oxygen transport and rapid water removal,sustaining high catalytic utilization under operational conditions.This strategy establishes TiN NTs scaffolds as a generalizable solution for the next generation of carbon-free,high-stability catalyst layers,offering practical guidance for durable and efficient fuel cell design. 展开更多
关键词 Proton exchange membrane fuel cells Cathode catalyst layer Electron interaction Water management Oxygen transport Stability
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Prolonged consumption of white beer increases levels of short-chain fatty acids and Prevotellaceae bacteria in mice 认领 引用
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作者 Zhaoxi Liu Yongheng Rong +5 位作者 Shuxia Huang Hua Yin Lushan Wang Shumin Hu Junhong Yu Min Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期67-79,共13页
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as... Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research. 展开更多
关键词 Gut microbiota Beer Cytokine Short-chain fatty acids White beer Prevotellaceae
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Dynamic urban development reshapes water‒food‒ecology nexus priorities:Evidence from 335 Chinese cities 认领 引用
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作者 Min Cao Yali Zhang +7 位作者 Junze Zhang Yuqing Xu Ji Xu Zifeng Yuan KaiWu Yu Chen Min Chen Guonian Lü 《Geography and Sustainability》 CSCD 2026年第2期251-264,共14页
The water‒food‒ecology nexus involves complex interdependencies,but existing studies often overlook multi sectoral bidirectional feedback and cross-border effects.Using geographically and temporally weighted regres si... The water‒food‒ecology nexus involves complex interdependencies,but existing studies often overlook multi sectoral bidirectional feedback and cross-border effects.Using geographically and temporally weighted regres sion and spatial simultaneous equations,we analyse water‒food‒ecology interactions across 335 Chinese cities(2000-2022).Our results reveal persistent spatial disparities.Cities with high-performance in all sectors remain scarce(<5%),with high-performance cities of water clustered in Southwest China,food in Northeast China,and ecology in key ecological protection zones.We find the bidirectional promotion between sectors accounted for 16.6%.The degree of water resource exploration and utilization,serving as a critical leverage point,shows bidirectional promotion with the municipal solid waste harmless treatment rate in ecology sector.Additionally,sectoral conflicts,particularly resource competition between per capita water consumption and ecological water use efficiency,and land competition between agriculture and forests,intensify with urban development.Our further cross-border analysis reveals asymmetric interactions:high-income cities’water overuse constrains eco logical protection in lower-middle-income cities,whereas food production in the latter enhances ecosystems in the former.These dynamics highlight the need for differentiated governance that targets leverage points such as optimization of water resource exploration and utilization as well as cross-regional compensation mechanisms to address negative spillover effects.Our framework advances water‒food‒ecology nexus management by integrat ing multi-sector feedback and spatial spillovers,providing a template for global sustainability strategies. 展开更多
关键词 Bidirectional feedback Cross-border Promotion and inhibition Urban sustainability Water‒food‒ecology nexus
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PhotosystemⅠcomplexes attached with phycocyanin from a cryptophytic alga 认领 引用
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作者 Min CHEN Xiaotong LI +1 位作者 Jingwen REN Mingri ZHAO 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第2期743-755,共13页
Three photosystem I(PSⅠ)particles associated with different amounts of light-harvesting complex I(LHCI)were isolated from a phycocyanin 645(PC645)-containing cryptophyte Chroomonas placoidea by Triton X-100 sucrose g... Three photosystem I(PSⅠ)particles associated with different amounts of light-harvesting complex I(LHCI)were isolated from a phycocyanin 645(PC645)-containing cryptophyte Chroomonas placoidea by Triton X-100 sucrose gradient centrifugation.Two active PSⅠ-LHCⅠparticles(Bands 4 and 5)were resolved from thylakoids stripped of cations only,which implied that LHC migration and the adjustment of energy distribution between photosystemⅡ(PSⅡ)and PSⅠfacilitated by cations could also occur in cryptophytes,like in higher plants.Peptide analysis revealed that 19.8-,10-,and 8.3-kDa peptides corresponding toβ,α1,andα2 subunits of PC645,respectively,were present in Bands 4 and 5.Analyses of fluorescence and circular dichroism spectra and Gauss analyses revealed efficient energy couplings between PC645 and chlorophyll within both of these PSⅠ-LHCⅠparticles.The excitation energy absorbed by PC645 could be directly transferred to chlorophyll a in the PSⅠcore or via the chlorophyll a/c-protein complex of LHCⅠ.Based on these observations,we designated the two PSⅠ-LHCⅠparticles as phycocyanin-PSⅠcomplexes,which have not been reported previously.Band 4-2 was a sub-complex of Band 4 and was almost depleted of LHCⅠ(the chlorophyll a/c-protein complex was designated as Band 4-1)and PC645.Therefore,Band 4-2 was recognized as the PSⅠcore complex.Negative staining and transmission electron microscopy images of Band 4 gave a direct view that the PC645 component attached with chlorophyll-protein complexes in a regular structure as hollow ring shape.Furthermore,while previous studies have indicated that PC645 associates with PSⅡ,our results reveal that,in this cryptophytic alga,PC645 exhibits structural—but not preferential—association with PSⅠ,which provided new information about the architecture and function of the energy transfer system comprising phycobiliproteins and chlorophyll-protein complexes in cryptophytes. 展开更多
关键词 cryptophyte phycocyanin-photosystem I(PSⅠ)complex sub-complex light-harvesting complex(LHCI) microstructure
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Atramacronins A-P,eudesmane-type sesquiterpenoid dimers from Atractylodes macrocephala with anti-hepatocellular carcinoma activities 认领 引用
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作者 Ganggang Zhou Xinru Li +10 位作者 Jiajia Liu Jiqiong Wang Zhaoyue Dong Ammara Khalid Yinda Qiu Zhihua Liao Guowei Wang Hui Liu Qingwen Zhang Min Chen Fancheng Meng 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期119-128,共10页
Atractylodes macrocephala Koidz.(A.macrocephala)is a medicinal and edible plant species belonging to the Compositae family.Its rhizome serves both therapeutic and nutritional purposes in China.This investigation led t... Atractylodes macrocephala Koidz.(A.macrocephala)is a medicinal and edible plant species belonging to the Compositae family.Its rhizome serves both therapeutic and nutritional purposes in China.This investigation led to the isolation of thirteen novel rearranged 9(8→7)-abeo-eudesmane-type sesquiterpenoid dimers(SDs),atramacronins A-M(1-13),three eudesmane-type SDs,atramacronins N-P(14-16),and two previously identified meroterpenoids,atrachinenin G(17)and atrachineninΙ(18),from Atractylodes macrocephala.Structure elucidation was accomplished through comprehensive spectroscopic analysis and single-crystal X-ray diffraction.Compounds 1,4-7,9,and 10 exhibited notable cytotoxicity against Hep3B,HepG2,and Huh7 cell lines,with half maximal inhibitory concentration(IC50)values ranging from 3.71 to 13.99μmol·L-1. 展开更多
关键词 Atractylodes macrocephala Sesquiterpenoid Cytotoxic activity Hepatocellular carcinoma
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Upcycling and Redesigning of Polyolefins 认领 引用
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作者 Min Chen Guifu Si Changle Chen 《Engineering》 SCIE EI CSCD 2026年第3期15-18,共4页
1.Background,Polyolefins were first commercialized in the 1930s by Imperial Chemical Industries(ICI)and were applied as underwater cable coatings.After almost a century of development,polyolefins have become one of th... 1.Background,Polyolefins were first commercialized in the 1930s by Imperial Chemical Industries(ICI)and were applied as underwater cable coatings.After almost a century of development,polyolefins have become one of the most widely used synthetic polymers,accounting for almost half of all global plastics production[1].Due to their many superior properties,they have found many everyday applications,but their annual production and widespread usage in single-use packaging have made them a major component of post-consumer plastic waste[2].Polyolefins are indispensable in the modern chemical industry and society,and their global market size is expected to grow rapidly in the foreseeable future.However,the current linear production and consumption of polyolefins is unsustainable and has created a serious environmental burden.Traditional recycling of polyolefins is performed via either mechanical recycling or pyrolysis. 展开更多
关键词 redesigning mechanical recycling polyolefins synthetic polymersaccounting upcycling pyrolysis underwater cable coatingsafter environmental burden
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Current colorectal cancer screening in developing countries:Identifying optimal approaches 认领 引用
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作者 Yan-Ping Wu Min Chen Lei Wang 《World Journal of Gastroenterology》 SCIE CAS 2026年第26期28-40,共13页
Colorectal cancer(CRC)screening has proven effective in reducing cancer-related mortality through early detection.Emerging epidemiological patterns,particularly the rising incidence of early-onset CRC and aging,call f... Colorectal cancer(CRC)screening has proven effective in reducing cancer-related mortality through early detection.Emerging epidemiological patterns,particularly the rising incidence of early-onset CRC and aging,call for changes for current inadequate CRC screening programs in developing countries.The benefits of CRC screening have come out in developed countries,while more prevailing environmental risk factors coupled with a gap in CRC screening implementation are observed in developing countries.Conventional screening modalities like fecal immunochemical tests are more acceptable,but lack sensitivity for advanced adenomas.Authoritative colonoscopy manifests high efficacy but suffers from poor adherence.Meanwhile,novel screening modalities require optimization.Comparatively high-adherence non-invasive tools could sort high-risk sets for colonoscopy.Growing evidence highlights the potential role of risk stratification approach beyond conventional age,which may refine colonoscopy referral.And microsimulation modeling is valuable for optimizing and evaluating screening strategies before and after screening.It suggests that an adaptive and organized screening framework may offer optimal population-level benefits. 展开更多
关键词 Colorectal cancer screening Risk stratification Microsimulation modeling Fecal immunochemical test Colonoscopy Early-onset colorectal cancer
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Decoding the glycocode:From structural diversity to engineering rules in microbial surface polysaccharides 认领 引用
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作者 Zhao-Xi Liu Min Chen 《Life Research》 2026年第3期1-3,共3页
Microbial surface glycans,capsular polysaccharides(CPS),O-antigens,lipooligosaccharides and glycoproteins,sit at the interface of host-microbe interactions.Recent technical and conceptual improvements have moved the f... Microbial surface glycans,capsular polysaccharides(CPS),O-antigens,lipooligosaccharides and glycoproteins,sit at the interface of host-microbe interactions.Recent technical and conceptual improvements have moved the field beyond descriptive identification toward a predictive glycobiology fueled by computation and simulation[1]:we can now visualize glycan architecture[2],synthesize defined glycoforms at scale[3],and engineer bacterial surfaces to test causality in host responses[4].These developments mark a conceptual shift in microbial glycobiology:microbial glycans are no longer viewed merely as taxonomic markers but are increasingly recognized as programmable biological information.In this context,Figure 1 outlines the comprehensive landscape of microbial glycan research,spanning from structural visualization and synthetic engineering to translational applications,thereby highlighting key future directions in the field. 展开更多
关键词 capsular polysaccharides structural diversity microbial surface polysaccharides O antigens test causality host responses engineering rules microbial surface glycanscapsular polysaccharides cps o antigenslipooligosaccharides visualize glycan architecture synthesize defined glycoforms
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Assembly of a high-quality reference genome and characterization of a chemical-mutagenized library of an elite soybean cultivar Tianlong 1 认领 引用 被引量：2
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作者 Yinghua Sheng Yicheng Huang +7 位作者 Zilun Jin Xuyan Wang Chenghui Liu Jingwen Zhang Zhipeng Zhou Chuang Ma Jianwei Zhang Min Chen 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第3期458-466,共9页
Soybean(Glycine max L.)is a globally vital crop for oil production and food security.High-quality genomic resources are instrumental for both functional genomics and breeding.Here,we report a near-complete,high-qualit... Soybean(Glycine max L.)is a globally vital crop for oil production and food security.High-quality genomic resources are instrumental for both functional genomics and breeding.Here,we report a near-complete,high-quality genome assembly of the elite cultivar Tianlong 1(TL1),featuring fully resolved telomeres and centromeres,as well as a gap-free assembly of 14 of its 20 chromosomes.On the basis of the genome assembly,we generate an ethyl methanesulfonate(EMS)-mutagenized population comprising 2555 M7 plants.Whole-genome resequencing of 288 EMS mutants uncovers 1,163,869 high-confidence single-nucleotide polymorphisms(SNPs)and 542,709 insertions/deletions(InDels),achieving 91.89%coverage of predicted protein-coding genes.Phenotypic screening demonstrates robust genotype–phenotype associations,with two nonsynonymous mutants displaying pronounced defects in seed and leaf development.Collectively,the chromosome-scale TL1 genome assembly and the extensively characterized mutant population establish valuable resources for functional genomics and precision breeding in soybean and related legume species. 展开更多
关键词 Soybean EMS mutant library Tianlong 1 SNPs InDels High-quality genome
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Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma 认领 引用 被引量：6
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作者 Yuan-Feng Zeng Yi-Sheng Xiao +4 位作者 Yong Liu Xiao-Jiang Luo Li-Dan Wen Qian Liu Min Chen 《World Journal of Gastroenterology》 SCIE CAS 2018年第34期3884-3897,共14页
AIM To clarify the underlying mechanism of formin-like 3(FMNL3)in the promotion of colorectal carcinoma(CRC)cell invasion.METHODS The in vitro biological function analyses of FMNL3 were performed by gain-and loss-of f... AIM To clarify the underlying mechanism of formin-like 3(FMNL3)in the promotion of colorectal carcinoma(CRC)cell invasion.METHODS The in vitro biological function analyses of FMNL3 were performed by gain-and loss-of function approaches.Changes in the F-actin cytoskeleton were detected by the technologies of phalloidin-TRITC labeling and confocal microscopy.The signaling pathway mediated by FMNL3 was explored by western blot,gelatin zymograph assay,co-immunoprecipitation(co-IP),immunofluorescence colocalization,and glutathione S-transferase(GST)pulldown assay.RESULTS The in vitro experimental results showed that FMNL3 significantly promoted the proliferation,invasion,and migration of CRC cells(P<0.05 and P<0.01).Moreover,FMNL3regulated the remodeling of actin-based protrusions such as filopodia and lamellipodia in a RhoC-dependent manner.The western blot and gelatin zymograph assay results indicated that FMNL3 was involved in the RhoC/focal adhesion kinase(FAK)pathway and acted as an effector of RhoC to activate the downstream signaling of p-FAK as well as p-MAPK and p-AKT.This resulted in the increased expression of matrix metalloproteinase 2(MMP2),matrix metalloproteinase 9(MMP9)and vascular endothelial growth factor(VEGF),and the subsequent promotion of CRC cell invasion.The results of TAE226,U0126 or Ly294002 treatment confirmed an essential role of FMNL3 in activation of the RhoC/FAK pathway and the subsequent promotion of CRC invasion.Co-IP,colocalization and GST pull-down assays showed the direct interaction of FMNL3 with RhoC in vivo and in vitro.CONCLUSION FMNL3 regulates the RhoC/FAK signaling pathway and RhoC-dependent remodeling of actin-based protrusions to promote CRC invasion. 展开更多
关键词 Formin-like 3 Colorectal carcinoma Invasion RhoC/FAK pathway Actin assembly
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Comprehensive genetic diagnosis of patients with Duchenne/Becker muscular dystrophy(DMD/BMD)and pathogenicity analysis of splice site variants in the DMD gene 认领 引用 被引量：5
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作者 Yan-mei YANG Kai YAN +7 位作者 Bei LIU Min CHEN Li-ya WANG Ying-zhi HUANG Ye-qing QIAN Yi-xi SUN Hong-ge LI Min-yue DONG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2019年第9期753-771,共19页
Duchenne muscular dystrophy(DMD)and Becker muscular dystrophy(BMD)are caused by mutations in the DMD gene.The aim of this study is to identify pathogenic DMD variants in probands and reduce the risk of recurrence of t... Duchenne muscular dystrophy(DMD)and Becker muscular dystrophy(BMD)are caused by mutations in the DMD gene.The aim of this study is to identify pathogenic DMD variants in probands and reduce the risk of recurrence of the disease in affected families.Variations in 100 unrelated DMD/BMD patients were detected by multiplex ligation-dependent probe amplification(MLPA)and next-generation sequencing(NGS).Pathogenic variants in DMD were successfully identified in all cases,and 11 of them were novel.The most common mutations were intragenic deletions(69%),with two hotspots located in the 5'end(exons 2–19)and the central of the DMD gene(exons 45–55),while point mutations were observed in 22%patients.Further,c.1149+1G>A and c.1150?2A>G were confirmed by hybrid minigene splicing assay(HMSA).This two splice site mutations would lead to two aberrant DMD isoforms which give rise to severely truncated protein.Therefore,the clinical use of MLPA,NGS,and HMSA is an effective strategy to identify variants.Importantly,eight embryos were terminated pregnancies according to prenatal diagnosis and a healthy boy was successfully delivered by preimplantation genetic diagnosis(PGD).Early and accurate genetic diagnosis is essential for prenatal diagnosis/PGD to reduce the risk of recurrence of DMD in affected families. 展开更多
关键词 Dystrophin gene Variation Genetic diagnosis Splice site mutation Hybrid minigene splicing assay
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EVALUATION OF CIRRHOTIC LIVER WITH PERFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING:A PRELIMINARY EXPERIMENTAL STUDY IN ANIMAL MODELS WITH HALF-LIVER CIRRHOSIS 认领 引用 被引量：6
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作者 Zheng-han Yang Xiao-hua Ye +5 位作者 Ye Tan Min Zhang Ming-zhu Zhou Jing-xia Xie Min Chen Cheng Zhou 《Chinese Medical Sciences Journal》 CAS 2006年第4期252-257,共6页
Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively inj... Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side （SS）, while the other half fiver without carbon tetrachloride injection was called as study control side （SCS）. Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid （Gd-DTPA） dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase （ MRSI）, peak time （ tp）, and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit （au）/s, respectively. Three parameters of curves didn＇t show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis. 展开更多
关键词 liver cirrhosis animal model magnetic resonance imaging perfusion imaging
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Contribution of root respiration to total soil respiration during non-growing season in mine reclaimed soil with different covering-soil thicknesses 认领 引用 被引量：4
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作者 Min Chen Xiaoyang Chen +3 位作者 Zhiyong Hu Tingyu Fan Shiwen Zhang Ying Liu 《International Journal of Coal Science & Technology》 EI CAS CSCD 2021年第5期1130-1137,共8页
An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems.This study investigated dynamic changes in root respiration and the contribution of root... An accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems.This study investigated dynamic changes in root respiration and the contribution of root respiration to total soil respiration(Rr/Rt ratio)during the non-growing season in mine reclaimed soil,with different covering-soil thicknesses.According to the covering-soil thicknesses,the study area was divided into four sites:10-25 cm(site A),25-45 cm(site B),45-55 cm(site C),and 55-65 cm(site D).From November 2017 to April 2018(except February in 2018),the soil respiration,root respiration,temperature at 5 cm,water content,and root biomass were measured.The results show that soil temperature and root respiration exhibited similar diurnal and monthly variations.The root respiration is strongly influenced by soil temperature during the non-growing season,with an exponential and positive relationship(P<0.001).Root respiration varies with the covering-soil thickness and is greatest with a covering-soil thickness of 25-45 cm.The Rr/Rt ratio also exhibits monthly variations.During the non-growing season,the mean value of the Rr/Rt ratio is 51.15%in mine reclaimed soil.The study indicates that root respiration is the primary source of soil respiration and is an important factor for estimating the potential emission of soil CO2 from mine reclaimed soil at the regional scale. 展开更多
关键词 Root respiration Soil respiration Soil temperature Soil water content Root biomass
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