Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could...Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could effectively alleviate drought-triggered leaf senescence and oxidative injury tocreeping bentgrass.Plants were exogenously irrigated with or without DA-6(0.4 mM·L-1)before being subjected to PEG-induced drought stress for 9 d.Drought stress resulted in significant growth retardation,Chl loss,and decreases in leaf relative water content,water use efficiency,photochemicalefficiency,and net photosynthetic rate,but significantly enhanced oxidative damage.Exogenous DA-6 markedly alleviated symptoms of drought stress byimproving water homeostasis,ROS scavenging,Chl biosynthesis,and photosynthesis.In contrast to untreated plants,the DA-6-pretreated creepingbentgrass demonstrated significantly higher transcript levels of genes related to rubisco activity(AsRuBisCo),and Chl biosynthesis(AsMg-CHT,AsPBGD,AsPOR,and AsCHLH),but lower transcript levels of Chl degradation-related genes(AsPAO,AsCLH,and AsPPH),and senescence-associated genes(Asl20 andAsh36),thereby decreasing leaf senescence and ameliorating photosynthetic performance under drought stress.Moreover,DA-6 also significantlypromoted activities of superoxide dismutase,peroxidase,catalase,and ascorbate peroxidase,hence efficiently diminishing drought-stimulated oxidativedamage.The current study supplies important information about DA-6-regulated growth and drought tolerance associated with osmotic adjustment,antioxidant defense,photosynthetic function,and Chl metabolism in cool-season turfgrass species.展开更多
The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the ...The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the Galileo L-band,the SLR-only,and the combined L-band/SLR dynamic precise orbit determination(POD)strategies by using the normal equations(NEQs)stacking,and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023,based on the Bei Dou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4.The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS)values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GNSS Experiment(COM)orbits,the corresponding values is 1.4 cm,2.5 cm,and 2.3 cm in Radial,the Tangential,and the Normal(RTN)direction,respectively.While the SLR-only 9-day arc length is optimal with the RTN values of 5.3 cm,30 cm,and 38.2 cm,as well as the 3D-RMS values of 48.9 cm.Encouragingly,the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm,0.6 cm and 1.2 cm in T-,and N-direction for the 3-and 5-day solution respectively.The corresponding values improve 0.7 cm and 0.9 cm,1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution.Take the E09 satellite as a case study,the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites increase.Furthermore,the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GNSS and SLR techniques.展开更多
The development of bio-inspired neural systems has emerged as a transformative approach to overcome the limitations of von Neumann architecture,replicating the remarkable energy efficiency and unified sensory-processi...The development of bio-inspired neural systems has emerged as a transformative approach to overcome the limitations of von Neumann architecture,replicating the remarkable energy efficiency and unified sensory-processing capabilities of biological neurons.In this work,we present a monolithic neuromorphic platform utilizing cascaded single-walled carbon nanotube thin-film transistors(SWCNT TFTs)that integrate Mini-light-emitting diodes(Mini-LEDs)with optoelectronic synaptic transistors,achieving synergistic optoelectronic integration.The SWCNT TFTs exhibit dual functionality:(1)as highly stable active-matrix drivers(>1000 operational cycles)enabling precise Mini-LED grayscale modulation,and(2)as efficient optoelectronic synaptic devices.Fabricated at wafer-scale with micrometer feature sizes,these devices demonstrate exceptional performance metrics,including low operating voltages(±1 V),high on/off ratios(106),near-ideal subthreshold swing(78 mV·dec-1),and precise Mini-LED current regulation(10-8A-10-4A)under 25 Hz pulsed gate operation.The optoelectronic synaptic devices based on organic-semiconductor heterojunction formed between poly(3,3”’-didodecyl quaterthiophene)(PQT-12)and semiconducting SWCNTs enable broadband photoresponses(365 nm-710 nm)through efficient charge transport,driven by TFT-controlled Mini-LED pulses.The implemented bio-inspired visual system successfully emulates fundamental synaptic functionalities,exhibiting excitatory postsynaptic currents(EPSC),short-term potentiation(STP),and long-term potentiation(LTP).Notably,we demonstrate system-level functionality through a five-layer convolutional neural network,achieving 92.02%accuracy on MNIST classification,while the monolithic integration establishes a biomimetic closed-loop“electrical-optical-electrical”pathway that faithfully simulates complete biological synaptic operation.This pioneering cascade of electronic,photonic,and optoelectronic components represents a significant advancement toward high-density,energy-efficient neuromorphic computing.展开更多
The widespread use and casual disposal of nanoproducts increase human exposure to nanoparticles(NPs),posing potential health risks.When coming into contact with biofluid,NPs passively move in the bloodstream and reach...The widespread use and casual disposal of nanoproducts increase human exposure to nanoparticles(NPs),posing potential health risks.When coming into contact with biofluid,NPs passively move in the bloodstream and reach target organs and cells.The nano-bio interactions,distribution,and fate of NPs are highly dependent on their physicochemical properties after direct exposure into the systemic circulation.In this study,silver nanoparticles(AgNPs)and gold nanoparticles(AuNPs)with the same size,shape,surface chemistry,and particle number but different densities were co-exposed to mice to explore their blood circulation and liver accumulation.The co-exposure avoids the individual differences in a single-material exposure model.Post-exposure,Au remained longer in the bloodstream than Ag,while 92.2%of the injected dose(%ID)of Ag accumulated in the liver compared to 78.0%for Au.Over a span of 3 to 72 h,Ag content in bloodstream increased while Au was undetectable.In the liver,the%ID of Ag sharply decreased to 9.4%,while the%ID of Au remained nearly unchanged.We proved the gradual dissociation of AgNPs into Ag ions using a fluorescent probe.Therefore,density-dependent dynamics of NPs in the blood caused greater liver accumulation of low-density Ag.However,the gradual degradation of AgNPs contributes to a high degree of distribution of Ag in the body while the AuNPs remain sequestered in the liver.This study implies that the dynamic transformation of NPs complicates their density-dependent retention,which are plausible to determine the accumulation and biological effects to the organisms.展开更多
Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population[1].VDD during childhood and adolescence has b...Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population[1].VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies[2].Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels[2,3].Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.展开更多
One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column...One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD.展开更多
Light is a crucial environmental factor regulating the sprouting of lily bulblets.Bulblets that developed under light conditions entered a germinated state,whereas those that formed in the dark remained dormant.Althou...Light is a crucial environmental factor regulating the sprouting of lily bulblets.Bulblets that developed under light conditions entered a germinated state,whereas those that formed in the dark remained dormant.Although light-mediated regulation of dormancy and germination has been studied mainly in photoblastic seeds such as those of Arabidopsis thaliana,the underlying mechanisms in modified organs such as lily bulbs are poorly understood.To determine how light signaling controls lily bulb sprouting and dormancy,we used the oriental hybrid lily'Siberia'.By constructing a transcriptome library of bulbs regenerated from scale cuttings under light/dark cultivation conditions,we identified Phytochrome-Interacting Factors 3(LoPIF3)as a key light signaling pathway regulator.Silencing LoPIF3 promoted sprouting,whereas LoPIF3 overexpression in A.thaliana delayed seed germination by affecting abscisic acid(ABA)pathways and increasing ABA sensitivity.Stable transformation experiments in Lilium longiflorum'White Heaven',along with metabolomic analysis of overexpression(OE)and RNA interference(RNAi)lines,revealed that LoPIF3 regulates sprouting by modulating bioactive gibberellin(GA)and ABA levels.Compared with wild-type(WT)lines,RNAi lines presented lower ABA and higher bioactive GAs levels,whereas OE lines presented lower GA4 and GA7 levels but no change in ABA levels,resulting in a greater ABA/GA ratio.Real-time quantitative PCR(RT-qPCR)confirmed that LoPIF3 bidirectionally regulated key genes in ABA and GA synthesis and metabolism,maintaining hormone balance.Exogenous gibberellin suppressed LoPIF3 expression and promoted germination,indicating that LoPIF3 responds to GA feedback and regulates downstream hormone networks.In conclusion,LoPIF3 mediates dormancy and germination light response processes by regulating the GA and ABA balance.This study reveals a novel mechanism of lightregulated sprouting in lilies and identifies LoPIF3 as a potential target for improving breeding.展开更多
Ge p-i-n resonant-cavity-enhanced photodetectors(RCE-PDs)grown on Si-on-insulator substrate are proposed and optimized at 1550 nm for high quantum efficiency and bandwidth.A vertical cavity is formed,consisting of a b...Ge p-i-n resonant-cavity-enhanced photodetectors(RCE-PDs)grown on Si-on-insulator substrate are proposed and optimized at 1550 nm for high quantum efficiency and bandwidth.A vertical cavity is formed,consisting of a buried oxide layer as the top reflector and Si/SiO2 distributed Bragg reflector(DBR)layers as the bottom reflector,to enhance the light-matter interaction within the Ge p-i-n structure.The results demonstrate the optimized Ge RCE-PDs can achieve the quantum efficiency of 23%for the 346 nm Ge thickness(34%for the 526 nm Ge thickness)and the high bandwidth of 70 GHz(50 GHz)at 1550 nm with 3 pairs of Si/SiO2 DBRs.These results indicate that the performance of the Ge RCE-PDs surpasses that of Ge PDs without RCE enhancement.展开更多
The rapid advancement of the Internet of Things(IoT)has transformed edge devices from simple data collectors into intelligent units capable of local processing and collaborative learning.However,the vast amounts of se...The rapid advancement of the Internet of Things(IoT)has transformed edge devices from simple data collectors into intelligent units capable of local processing and collaborative learning.However,the vast amounts of sensitive data generated by these devices face severe constraints from“data silos”and risks of privacy breaches.Federated learning(FL),as a distributed collaborative paradigm that avoids sharing raw data,holds great promise in the IoT domain.Nevertheless,it remains vulnerable to gradient leakage threats.While traditional differential privacy(DP)techniques mitigate privacy risks,they often come at the cost of significantly reduced model performance—a limitation particularly pronounced in resource-constrained IoT environments characterised by non-independent and identically distributed(non-IID)data distribution.To bridge the gap between privacy preservation and high performance on heterogeneous data,this paper proposes a novel personalized federated learning(PFL)method,FedGLP-ADP.This method leverages historical gradient information to provide a more detailed partitioning of parameters,aiming to prevent personalized knowledge from being affected by noise as much as possible,thereby reducing model degradation.Building on this,we propose an adaptive DP mechanism that optimizes both the clipping and noising steps to minimize the impact of noise on global knowledge.Experimental results show that FedGLP-ADP exhibits superior performance compared to other representative methods under different privacy levels and non-IID degrees.展开更多
This study proposes a self-branching strategy integrated with local asymmetric sites(SFSI)to address the pervasive kinetics-stability dilemma in potassium-ion batteries(PIBs).This approach drives in-situ transformatio...This study proposes a self-branching strategy integrated with local asymmetric sites(SFSI)to address the pervasive kinetics-stability dilemma in potassium-ion batteries(PIBs).This approach drives in-situ transformation of a symmetric poly(L-lysine)-4-valent-branched benzimidazole polymer(PV-B)into an asymmetric benzimidazole branched polymer(PVB).The resulting asymmetric PVB exhibits moderate dipole interactions with K+,facilitating salt dissociation and elevating ion conductivity.Concurrently,it shows a strong dipole moment with FSI-/Sex-ion,promoting rapid ion transport and suppressing the shuttle effect of Se species.This favorable dipole polarization,combined with robust mechanical stability that stems from the creatively asymmetric protocol for polymer electrolytes via the anhydride-transfer amidation mechanism to the coupling of strong solvation benzimidazole branch and weak solvation amide branch,guides excellent electrochemical kinetics and superior long-term stability.Consequently,the fabricated BiSbSe3@C@PVB achieves a harmonious high-rate capability of 313.7 mAh g-1at 10 A g-1and exceptional long-term durability,maintaining high-capacity retention over 2000 cycles.This work highlights the importance of a biomimetic,in-situ constructed asymmetric interface for precisely tailoring carrier transport and interfacial stability,providing a novel paradigm for the design of highperformance energy storage devices.展开更多
This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,Calcu...This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems.展开更多
Optical frequency combs have revolutionized numerous fields of modern science,particularly precision metrology and molecular spectroscopy.However,they inherently suffer from electronic and optical noise,which restrict...Optical frequency combs have revolutionized numerous fields of modern science,particularly precision metrology and molecular spectroscopy.However,they inherently suffer from electronic and optical noise,which restricts their coherent spectral extension into critical mid-infrared and terahertz(THz)regimes,thereby demanding complex active stabilization systems.Here,we introduce a passive noise suppression technique based on the soliton self-frequency shift(SSFS)in optical fibers.Our method spectrally shifts a comb to a low-noise region,effectively isolating it from the initial parasitic optical noise and achieving simultaneous reductions of 15 dB in phase noise and 20 dB in intensity noise,as verified on a femtosecond electro-optic comb.This comb is then coherently extended into the 6 to 13μm mid-infrared range via difference-frequency generation in a GaSe crystal and into the 0.1 to 5 THz range through optical-toTHz conversion in a photoconductive antenna.Our passive noise-suppression method is broadly applicable to other comb platforms,including mode-locked lasers and on-chip microcombs,whereas the broadband comb source is promising for various spectroscopic sensing applications.展开更多
Under study in this paper is a nonlinear Schrödinger equation with local and nonlocal nonlinearities,which originates from the parity-symmetric reduction of the Manakov system and has applications in some physica...Under study in this paper is a nonlinear Schrödinger equation with local and nonlocal nonlinearities,which originates from the parity-symmetric reduction of the Manakov system and has applications in some physical systems with the parity symmetry constraint between two fields/components.Via the Riemann-Hilbert method,the theory of inverse scattering transform with the presence of double poles is extended for this equation under nonzero boundary conditions(NZBCs).Also,the double-pole soliton solutions with NZBCs are derived in the reflectionless case.It is shown that the quasi-periodic beating solitons can be obtained when the double pole lies off the circleΓcentered at the origin with radius √2q0(where q0 is the modulus of NZBCs)on the spectrum plane.Moreover,using the improved asymptotic analysis method,the asymptotic solitons are found to be located in some logarithmic curves of the xt plane.展开更多
Tilting basal texture is recognized as a potentially effective strategy for optimizing the room–temperature(RT)formability of magnesium alloy sheets.However,the unclear quantitative relationship between the RT formab...Tilting basal texture is recognized as a potentially effective strategy for optimizing the room–temperature(RT)formability of magnesium alloy sheets.However,the unclear quantitative relationship between the RT formability and basal texture tilting degree of magnesium alloy sheet as well as the unrevealed intrinsic mechanisms linking them renders this strategy immature yet.This work comprehensively investigates the influence of basal texture tilting angle(BTTA)on the RT stretch formability of AZ31 magnesium alloy sheets,as well as the plastic deformation mechanism operation and strain accommodation capability during forming process.The results show that the formability of every texture-effectively tilted sheet with a BTTA>0°is significantly improved as compared to that of initial sheet orientating the c-axis of most grains toward the normal direction.Moreover,the formability optimization effect exhibits a trend of initial increase followed by decrease with increasing BTTA,which is primarily attributed to the differential response behaviors of plastic deformation mechanism operation and strain accommodation to BTTA in the upper regions among these sheets.Given that BTTA is>0°butslip dominates the plastic deformation.The positive correlation between formability gain and BTTA benefits greatly from the continuously enhanced initial basal slip ability and the reduced orientation hardening rate.When BTTA is≥60°butslip,along with the orientation softening for basal slip,promotes the formability improvement.Once BTTA approaches 90°,the profuse formation of{10-12}tension twin is a main contribution to the formability increment.Additionally,the evolution pattern of thickness-direction strain accommodation capability(ravg.value)with increasing BTTA is completely consistent with the I.E.value.Specially,due to the strong initial basal slip ability,numerous tension twins with soft orientation for basal slip formed during the early forming stage,the continuous orientation softening for basal slip in matrix and the highest thickness-direction strain accommodation capability,the sheet with a BTTA of 60°shows the optimal RT formability manifested as an I.E.value of 7.6 mm which represents a∼217%enhancement compared to the initial sheet with a BTTA of 0°.This work deepens the understanding of tilting basal texture for optimizing formability and provides theoretical foundations for the reverse design and development of magnesium alloy sheets with high RT formability.展开更多
Objective:To explore the application effect of the intelligent blood collection system in the outpatient blood collection of cancer specialized hospitals,and to provide a basis for improving the quality of outpatient ...Objective:To explore the application effect of the intelligent blood collection system in the outpatient blood collection of cancer specialized hospitals,and to provide a basis for improving the quality of outpatient blood collection nursing and the medical experience of patients.Methods:136,274 blood specimens collected using the traditional manual blood collection mode from January to June 2020 were selected as the control group,and 176,989 blood specimens collected using the intelligent blood collection system from January to June 2021 were selected as the observation group.The blood collection process time,blood specimen quality,incidence of adverse events and patient satisfaction of the two groups were compared.Measurement data were expressed as x±s and analyzed by t-test.Counting data were expressed as cases(%),and theχ2test was used.A p value<0.05 was considered statistically significant.Results:The registration and number collection time,specimen submission time and total process time of the observation group were significantly shorter than those of the control group(p<0.001).The total error rate of blood samples decreased from 0.374%to 0.050%,and the error rate of blood collection tube usage decreased from 3.8%to 0.7%.The patient satisfaction rate increased from 88%to 96%,and the differences were statistically significant(p<0.05).Conclusion:The intelligent blood collection system can optimize the outpatient blood collection process,shorten the service duration,reduce the error rate of specimens,improve the efficiency of nursing and patient satisfaction,and has good application value in the outpatient blood collection management of tumor specialized hospitals.展开更多
This study assessed the health‑related quality of life(HRQoL)of Chinese patients with mucopolysaccharidosis type Ⅱ(MPS Ⅱ)and explored key factors associated with HRQoL.A cross‑sectional survey was conducted in Febru...This study assessed the health‑related quality of life(HRQoL)of Chinese patients with mucopolysaccharidosis type Ⅱ(MPS Ⅱ)and explored key factors associated with HRQoL.A cross‑sectional survey was conducted in February 2023 through the China Rare Disease Alliance Cloud Service Platform,in which patients with MPS Ⅱ and their family members completed an online questionnaire collecting information on Pediatric Quality of Life Inventory(PedsQL)Version 4.0 scores,sociodemographic characteristics,and clinical features.Descriptive statistics were used to summarize patient characteristics and HRQoL levels,and multiple linear and logistic regression analyses were performed to identify factors influencing HRQoL.Data were obtained from 129 individuals across 22 regions in China,the majority of whom were boys(98%),with a mean age of 8.7 years.Initial symptoms appeared at approximately 2.5 years of age,yet diagnosis was often delayed by more than one year,and over half of the children(57%)had previously received an incorrect diagnosis.On average,nearly ten body systems were affected.Overall HRQoL was low,with a mean score of 30.08(standard deviation(SD)=19.51).Domain‑specific scores were 30.98 for daily activities,43.18 for emotional well‑being,24.73 for social functioning,and 20.89 for school participation,indicating substantial difficulties in performing routine tasks.Multiple linear regression(adjusted R²=0.381)showed that HRQoL significantly declined with increasing age(β=−2.000,P=0.003)and the presence of neurological or cognitive impairments(β=−12.798,P<0.001),whereas school attendance was a strong positive predictor of higher HRQoL(β=16.330,P<0.001).Overall,Chinese patients with MPS Ⅱ demonstrated markedly reduced HRQoL,particularly in cognitive and daily functioning domains,underscoring the need for improved clinical management and supportive strategies to enhance their well‑being.展开更多
Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis...Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis of 197 patients undergoing prostate biopsy with prostate-specific antigens between 4 and 10 ng ml^?1 was conducted.Of these,47 patients were confirmed to have cancer,while the remaining 150 patients were diagnosed with benign prostate disease after examining biopsy pathology.Two multivariate logistic regression models were established including age,prostate volumes,freeotal prostate-specific antigen ratio,and prostate-specific antigen density using SPSS 19.0 to obtain the predicted probability and Logit P,and then,two receiver operating characteristic(ROC)curves were drawn to obtain the best cutoff value for prostate biopsy:one for the group of all the prostate cancers and one for the group of clinically significant prostate cancers.The best cutoff value for prostate biopsy was 0.25 from the multivariate logistic regression ROC curve model of all the prostate cancers,which gave a sensitivity of 75.4%and a specificity of 75.8%.The best cutoff value for prostate biopsy was 0.20 from the multivariate logistic regression model of clinically significant prostate cancers,which gave a sensitivity of 76.7%and a specificity of 80.1%.We identified the best cutoff values for prostate biopsy(0.25 for all prostate cancers and 0.20 for clinically significant prostate cancers)to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone.展开更多
Objective:To address the poor prognosis of patients caused by the weak knowledge and non-standard operation of blood glucose management among non-endocrinology specialist nurses during the perioperative period,this st...Objective:To address the poor prognosis of patients caused by the weak knowledge and non-standard operation of blood glucose management among non-endocrinology specialist nurses during the perioperative period,this study aims to establish a scientific and systematic structured training system.Through a training model that combines theory with practice,it aims to enhance the perioperative blood glucose management ability of nurses,improve the blood glucose control effect,and clinical outcomes of patients.Method:A mixed research method was adopted.The training theoretical framework was constructed through literature analysis.The weights of the course modules were determined by combining semi-structured interviews(n=35)and two rounds of Delphi expert inquiries(expert authority coefficient 0.89)(first-level indicator weights:theoretical foundation 0.25,skill operation 0.35,clinical application 0.28,emergency treatment 0.12).Finally,a structured training program containing 4 first-level indicators and 12 second-level indicators was formed.A total of 86 non-endocrinology specialist nurses(working years 2–15 years,average 6.8±3.2 years;professional titles:32 nurses,38 senior nurses,16 charge nurses)were selected by stratified random sampling and underwent a 4-week training.The training included theoretical lectures,scenario simulations,case studies,and bedside practical operations.After the training,the effects were comprehensively evaluated through theoretical assessments,operational scores,and patients’blood glucose monitoring data.Result:After the training,the standardized rate of perioperative blood glucose monitoring among nurses increased from 54.2%to 91.7%(p<0.001),the qualified rate of standardized insulin injection increased from 58.3%to 91.8%(p<0.001),and the average score of theoretical assessment increased from 62.5±8.3 points to 89.6±5.7 points(p<0.001).The preoperative blood glucose compliance rate of patients increased from 54.3%to 76.8%(p<0.001),the 24-hour blood glucose fluctuation range after surgery decreased from(5.8±1.6)mmol/L to(2.9±0.9)mmol/L(p<0.001),and the incidence of perioperative hypoglycemic events decreased from 8.0%to 2.0%(p=0.008).Multivariate analysis showed that nurses with a training duration of≥4 weeks had a 68%lower risk of postoperative infection in the patients under their charge(OR=0.32,95%CI 0.13–0.79).Conclusion:Structured training significantly enhances the perioperative blood glucose management ability of non-endocrinology specialist nurses and improves the clinical outcomes of patients.It is suggested that such training be incorporated into the compulsory content of nurses’continuing education,a regional homogeneous training and certification system be established,and patient-participatory evaluation tools and digital training platforms be developed to promote the continuous improvement of perioperative nursing quality.展开更多
Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reaction...Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reactions.Herein,the ultrasmall Ru nanoclusters(~0.9 nm)were successfully fabricated over P25 support with positive charged Ruδ+species at the interface.A new route was developed to achieve the furfural(FAL)to furfurylamine(FAM)by coupling the light-driven reductive amination and hydrogen transfer of ethanol over this type catalyst.Strikingly,the photocatalytic activity and selectivity are strongly dependent on the particle size and electronic structure of Ruthenium.The Ruδ+species at the interface promote the formation of active imine intermediates;moreover,the Ru nanoclusters facilitate the separation efficiency of electrons and holes as well as accelerate the further hydrogenation of imine intermediates to product primary amines.In contrast Ru particles in larger nanometer size facilitate the formation of the furfuryl alcohol and excessive hydrogenation products.In addition,the coupling byproducts can be effectively inhibited via the construction of sub-nanocluster.This study offers a new path to produce the primary amines from biomass-derived carbonyl compounds over hybrid semiconductor/metal-clusters photocatalyst via light-driven tandem catalytic process.展开更多
Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients...Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients with refractory peripheral facial paralysis were treated with the combination of warming-needle moxibustion and stuck-needle-pulling technique.The treatment was given once daily and there were 2 days at interval after consecutive 5 treatments.A total of 10 treatments made one course and consecutive 2 courses of treatment were required.Before and after treatment,HouseBrackmann(H-B)facial nerve grading scale score was adopted to evaluate the degree of facial paralysis in the patients and the clinical effect was assessed.Results:After treatment,the mean H-B score was higher than that before treatment in the patients,indicating a statistical significance(P<0.05).After treatment,of 33 cases,12 cases were cured,9 cases effective remarkably,8 cases effective and 4 cases no effect.The total effective rate was 87.88%.Conclusion:The combination treatment of warming-needle moxibustion and stuck-needle-pulling technique achieves a definite effect on refractory peripheral facial paralysis.展开更多
基金supported by the Sichuan Students'Innovation Training Program(S202410626051).
摘要Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could effectively alleviate drought-triggered leaf senescence and oxidative injury tocreeping bentgrass.Plants were exogenously irrigated with or without DA-6(0.4 mM·L-1)before being subjected to PEG-induced drought stress for 9 d.Drought stress resulted in significant growth retardation,Chl loss,and decreases in leaf relative water content,water use efficiency,photochemicalefficiency,and net photosynthetic rate,but significantly enhanced oxidative damage.Exogenous DA-6 markedly alleviated symptoms of drought stress byimproving water homeostasis,ROS scavenging,Chl biosynthesis,and photosynthesis.In contrast to untreated plants,the DA-6-pretreated creepingbentgrass demonstrated significantly higher transcript levels of genes related to rubisco activity(AsRuBisCo),and Chl biosynthesis(AsMg-CHT,AsPBGD,AsPOR,and AsCHLH),but lower transcript levels of Chl degradation-related genes(AsPAO,AsCLH,and AsPPH),and senescence-associated genes(Asl20 andAsh36),thereby decreasing leaf senescence and ameliorating photosynthetic performance under drought stress.Moreover,DA-6 also significantlypromoted activities of superoxide dismutase,peroxidase,catalase,and ascorbate peroxidase,hence efficiently diminishing drought-stimulated oxidativedamage.The current study supplies important information about DA-6-regulated growth and drought tolerance associated with osmotic adjustment,antioxidant defense,photosynthetic function,and Chl metabolism in cool-season turfgrass species.
基金under the support of the National Natural Science Foundation of China(Grant No.42388102),ChinaYouth Fund of the Natural Science Foundation of Hebei Province(Grant No.D2023523003),China。
摘要The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the Galileo L-band,the SLR-only,and the combined L-band/SLR dynamic precise orbit determination(POD)strategies by using the normal equations(NEQs)stacking,and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023,based on the Bei Dou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4.The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS)values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GNSS Experiment(COM)orbits,the corresponding values is 1.4 cm,2.5 cm,and 2.3 cm in Radial,the Tangential,and the Normal(RTN)direction,respectively.While the SLR-only 9-day arc length is optimal with the RTN values of 5.3 cm,30 cm,and 38.2 cm,as well as the 3D-RMS values of 48.9 cm.Encouragingly,the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm,0.6 cm and 1.2 cm in T-,and N-direction for the 3-and 5-day solution respectively.The corresponding values improve 0.7 cm and 0.9 cm,1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution.Take the E09 satellite as a case study,the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites increase.Furthermore,the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GNSS and SLR techniques.
基金supported by the Natural Science Foundation of China(62274174)National Key Research and Development Program of China(2020YFA0714700)+2 种基金Basic Research Program of Jiangsu(BK20232009)a fellowship from the China Postdoctoral Science Foundation(2023M742559)the Cooperation Project of Vacuum Interconnect Research Facility(NANO-X)of Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences(F2208)。
摘要The development of bio-inspired neural systems has emerged as a transformative approach to overcome the limitations of von Neumann architecture,replicating the remarkable energy efficiency and unified sensory-processing capabilities of biological neurons.In this work,we present a monolithic neuromorphic platform utilizing cascaded single-walled carbon nanotube thin-film transistors(SWCNT TFTs)that integrate Mini-light-emitting diodes(Mini-LEDs)with optoelectronic synaptic transistors,achieving synergistic optoelectronic integration.The SWCNT TFTs exhibit dual functionality:(1)as highly stable active-matrix drivers(>1000 operational cycles)enabling precise Mini-LED grayscale modulation,and(2)as efficient optoelectronic synaptic devices.Fabricated at wafer-scale with micrometer feature sizes,these devices demonstrate exceptional performance metrics,including low operating voltages(±1 V),high on/off ratios(106),near-ideal subthreshold swing(78 mV·dec-1),and precise Mini-LED current regulation(10-8A-10-4A)under 25 Hz pulsed gate operation.The optoelectronic synaptic devices based on organic-semiconductor heterojunction formed between poly(3,3”’-didodecyl quaterthiophene)(PQT-12)and semiconducting SWCNTs enable broadband photoresponses(365 nm-710 nm)through efficient charge transport,driven by TFT-controlled Mini-LED pulses.The implemented bio-inspired visual system successfully emulates fundamental synaptic functionalities,exhibiting excitatory postsynaptic currents(EPSC),short-term potentiation(STP),and long-term potentiation(LTP).Notably,we demonstrate system-level functionality through a five-layer convolutional neural network,achieving 92.02%accuracy on MNIST classification,while the monolithic integration establishes a biomimetic closed-loop“electrical-optical-electrical”pathway that faithfully simulates complete biological synaptic operation.This pioneering cascade of electronic,photonic,and optoelectronic components represents a significant advancement toward high-density,energy-efficient neuromorphic computing.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XPDB0750300)the National Natural Science Foundation of China (Nos. 22036002, 22325606,22206037, 22106176, and 21527901)the Scientific Instrument and Equipment Developing Project of the Chinese Academy of Sciences (No.YJKYYQ20210020).
摘要The widespread use and casual disposal of nanoproducts increase human exposure to nanoparticles(NPs),posing potential health risks.When coming into contact with biofluid,NPs passively move in the bloodstream and reach target organs and cells.The nano-bio interactions,distribution,and fate of NPs are highly dependent on their physicochemical properties after direct exposure into the systemic circulation.In this study,silver nanoparticles(AgNPs)and gold nanoparticles(AuNPs)with the same size,shape,surface chemistry,and particle number but different densities were co-exposed to mice to explore their blood circulation and liver accumulation.The co-exposure avoids the individual differences in a single-material exposure model.Post-exposure,Au remained longer in the bloodstream than Ag,while 92.2%of the injected dose(%ID)of Ag accumulated in the liver compared to 78.0%for Au.Over a span of 3 to 72 h,Ag content in bloodstream increased while Au was undetectable.In the liver,the%ID of Ag sharply decreased to 9.4%,while the%ID of Au remained nearly unchanged.We proved the gradual dissociation of AgNPs into Ag ions using a fluorescent probe.Therefore,density-dependent dynamics of NPs in the blood caused greater liver accumulation of low-density Ag.However,the gradual degradation of AgNPs contributes to a high degree of distribution of Ag in the body while the AuNPs remain sequestered in the liver.This study implies that the dynamic transformation of NPs complicates their density-dependent retention,which are plausible to determine the accumulation and biological effects to the organisms.
基金supported by grants from the National Natural Science Foundation of China(G.F.Wang,grant number 82204071)(P.Y.Su,grant numbers 81874268 and 82473655)the Research Funds of the Center for Big Data and Population Health of IHM(P.Y.Su,No.JKS2023016)Anhui Provincial Health Commission Scientific Research Project(Y.Zhou,No.AHWJ2023A30027)。
摘要Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population[1].VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies[2].Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels[2,3].Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.
基金supported by grants from National Natural Science Foundation of China(82304113,22107089 and 52271251)the Science and Technology Research Project of Henan Province(242102310526 and 232102310041)+1 种基金the Key project of Natural Science Foundation of Henan Province(242300421210)the Doctoral Scientific Research Foundation of Xinxiang Medical University(XYBSKYZZ202123)。
摘要One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD.
基金supported by the National Key R&D Program of China(Grant No.2022YFD1200504)the National Natural Science Foundation of China(Grant No.32372741)the earmarked fund for CARS(Grant No.CARS-23)。
摘要Light is a crucial environmental factor regulating the sprouting of lily bulblets.Bulblets that developed under light conditions entered a germinated state,whereas those that formed in the dark remained dormant.Although light-mediated regulation of dormancy and germination has been studied mainly in photoblastic seeds such as those of Arabidopsis thaliana,the underlying mechanisms in modified organs such as lily bulbs are poorly understood.To determine how light signaling controls lily bulb sprouting and dormancy,we used the oriental hybrid lily'Siberia'.By constructing a transcriptome library of bulbs regenerated from scale cuttings under light/dark cultivation conditions,we identified Phytochrome-Interacting Factors 3(LoPIF3)as a key light signaling pathway regulator.Silencing LoPIF3 promoted sprouting,whereas LoPIF3 overexpression in A.thaliana delayed seed germination by affecting abscisic acid(ABA)pathways and increasing ABA sensitivity.Stable transformation experiments in Lilium longiflorum'White Heaven',along with metabolomic analysis of overexpression(OE)and RNA interference(RNAi)lines,revealed that LoPIF3 regulates sprouting by modulating bioactive gibberellin(GA)and ABA levels.Compared with wild-type(WT)lines,RNAi lines presented lower ABA and higher bioactive GAs levels,whereas OE lines presented lower GA4 and GA7 levels but no change in ABA levels,resulting in a greater ABA/GA ratio.Real-time quantitative PCR(RT-qPCR)confirmed that LoPIF3 bidirectionally regulated key genes in ABA and GA synthesis and metabolism,maintaining hormone balance.Exogenous gibberellin suppressed LoPIF3 expression and promoted germination,indicating that LoPIF3 responds to GA feedback and regulates downstream hormone networks.In conclusion,LoPIF3 mediates dormancy and germination light response processes by regulating the GA and ABA balance.This study reveals a novel mechanism of lightregulated sprouting in lilies and identifies LoPIF3 as a potential target for improving breeding.
基金supported by the Fujian Provincial Education and Research Project for Young and Middle-Aged Teachers Program of China(No.JAT201030)the Provincial Ministerial Level Scientific Research Cultivation Project of Chengyi College,Jimei university(No.CK23045)。
摘要Ge p-i-n resonant-cavity-enhanced photodetectors(RCE-PDs)grown on Si-on-insulator substrate are proposed and optimized at 1550 nm for high quantum efficiency and bandwidth.A vertical cavity is formed,consisting of a buried oxide layer as the top reflector and Si/SiO2 distributed Bragg reflector(DBR)layers as the bottom reflector,to enhance the light-matter interaction within the Ge p-i-n structure.The results demonstrate the optimized Ge RCE-PDs can achieve the quantum efficiency of 23%for the 346 nm Ge thickness(34%for the 526 nm Ge thickness)and the high bandwidth of 70 GHz(50 GHz)at 1550 nm with 3 pairs of Si/SiO2 DBRs.These results indicate that the performance of the Ge RCE-PDs surpasses that of Ge PDs without RCE enhancement.
基金supported by the Chongqing Research Program of Basic Research and Frontier Technology(Chongqing Talent)(Grant No.cstc2024ycjh-bgzxm0048).
摘要The rapid advancement of the Internet of Things(IoT)has transformed edge devices from simple data collectors into intelligent units capable of local processing and collaborative learning.However,the vast amounts of sensitive data generated by these devices face severe constraints from“data silos”and risks of privacy breaches.Federated learning(FL),as a distributed collaborative paradigm that avoids sharing raw data,holds great promise in the IoT domain.Nevertheless,it remains vulnerable to gradient leakage threats.While traditional differential privacy(DP)techniques mitigate privacy risks,they often come at the cost of significantly reduced model performance—a limitation particularly pronounced in resource-constrained IoT environments characterised by non-independent and identically distributed(non-IID)data distribution.To bridge the gap between privacy preservation and high performance on heterogeneous data,this paper proposes a novel personalized federated learning(PFL)method,FedGLP-ADP.This method leverages historical gradient information to provide a more detailed partitioning of parameters,aiming to prevent personalized knowledge from being affected by noise as much as possible,thereby reducing model degradation.Building on this,we propose an adaptive DP mechanism that optimizes both the clipping and noising steps to minimize the impact of noise on global knowledge.Experimental results show that FedGLP-ADP exhibits superior performance compared to other representative methods under different privacy levels and non-IID degrees.
基金funding from the National Natural Science Foundation of China(Grant Nos.22175103,22178191)financial support from the Taishan Scholar Project(Project No.tsqn202306217)。
摘要This study proposes a self-branching strategy integrated with local asymmetric sites(SFSI)to address the pervasive kinetics-stability dilemma in potassium-ion batteries(PIBs).This approach drives in-situ transformation of a symmetric poly(L-lysine)-4-valent-branched benzimidazole polymer(PV-B)into an asymmetric benzimidazole branched polymer(PVB).The resulting asymmetric PVB exhibits moderate dipole interactions with K+,facilitating salt dissociation and elevating ion conductivity.Concurrently,it shows a strong dipole moment with FSI-/Sex-ion,promoting rapid ion transport and suppressing the shuttle effect of Se species.This favorable dipole polarization,combined with robust mechanical stability that stems from the creatively asymmetric protocol for polymer electrolytes via the anhydride-transfer amidation mechanism to the coupling of strong solvation benzimidazole branch and weak solvation amide branch,guides excellent electrochemical kinetics and superior long-term stability.Consequently,the fabricated BiSbSe3@C@PVB achieves a harmonious high-rate capability of 313.7 mAh g-1at 10 A g-1and exceptional long-term durability,maintaining high-capacity retention over 2000 cycles.This work highlights the importance of a biomimetic,in-situ constructed asymmetric interface for precisely tailoring carrier transport and interfacial stability,providing a novel paradigm for the design of highperformance energy storage devices.
基金supported in part by the Mining Hydraulic Technology and Equipment Engineering Research Center,Liaoning Technical University,Fuxin,China(Grant No.MHTE23-R04)the Fundamental Research Funds for the Central Universities(ID N25BSS068).
摘要This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems.
基金supported by the Innovation Program for Quantum Science and Technology(Grant No.2023ZD0301000)the National Natural Science Foundation of China(Grant Nos.62035005 and 62235019)+1 种基金the Research Project of Shanghai Science and Technology Commission(Grant No.22560730400)the Chongqing Technology Innovation and Application Development Project(Grant No.CSTB2022TIAD-DEX0031)。
摘要Optical frequency combs have revolutionized numerous fields of modern science,particularly precision metrology and molecular spectroscopy.However,they inherently suffer from electronic and optical noise,which restricts their coherent spectral extension into critical mid-infrared and terahertz(THz)regimes,thereby demanding complex active stabilization systems.Here,we introduce a passive noise suppression technique based on the soliton self-frequency shift(SSFS)in optical fibers.Our method spectrally shifts a comb to a low-noise region,effectively isolating it from the initial parasitic optical noise and achieving simultaneous reductions of 15 dB in phase noise and 20 dB in intensity noise,as verified on a femtosecond electro-optic comb.This comb is then coherently extended into the 6 to 13μm mid-infrared range via difference-frequency generation in a GaSe crystal and into the 0.1 to 5 THz range through optical-toTHz conversion in a photoconductive antenna.Our passive noise-suppression method is broadly applicable to other comb platforms,including mode-locked lasers and on-chip microcombs,whereas the broadband comb source is promising for various spectroscopic sensing applications.
基金supported by the Beijing Natural Science Foundations(Grant Nos.1232022 and 1252016)the National Natural Science Foundations of China(Grant Nos.12475003 and 11705284)the Hebei Province Natural Science Foundation(Grant No.A2025502019)。
摘要Under study in this paper is a nonlinear Schrödinger equation with local and nonlocal nonlinearities,which originates from the parity-symmetric reduction of the Manakov system and has applications in some physical systems with the parity symmetry constraint between two fields/components.Via the Riemann-Hilbert method,the theory of inverse scattering transform with the presence of double poles is extended for this equation under nonzero boundary conditions(NZBCs).Also,the double-pole soliton solutions with NZBCs are derived in the reflectionless case.It is shown that the quasi-periodic beating solitons can be obtained when the double pole lies off the circleΓcentered at the origin with radius √2q0(where q0 is the modulus of NZBCs)on the spectrum plane.Moreover,using the improved asymptotic analysis method,the asymptotic solitons are found to be located in some logarithmic curves of the xt plane.
基金supports from the National Natural Science Foundation of China(52161023,51901204)Scientific and Technological project of Yunnan Precious Metals Laboratory(YPML-20240502006,YPML-2023050208,YPML-20240502096,YPML-20240502081)+2 种基金Yunnan Science and Technology Planning Project(202301AT070276,202404CC110018,202403AA080007,202502AB080015)Yunnan Luo Zhifu Expert Workstation(202305AF150169)Anhui Provincial Department of Education Research Project-Major Project(NO.2022AH040199).
摘要Tilting basal texture is recognized as a potentially effective strategy for optimizing the room–temperature(RT)formability of magnesium alloy sheets.However,the unclear quantitative relationship between the RT formability and basal texture tilting degree of magnesium alloy sheet as well as the unrevealed intrinsic mechanisms linking them renders this strategy immature yet.This work comprehensively investigates the influence of basal texture tilting angle(BTTA)on the RT stretch formability of AZ31 magnesium alloy sheets,as well as the plastic deformation mechanism operation and strain accommodation capability during forming process.The results show that the formability of every texture-effectively tilted sheet with a BTTA>0°is significantly improved as compared to that of initial sheet orientating the c-axis of most grains toward the normal direction.Moreover,the formability optimization effect exhibits a trend of initial increase followed by decrease with increasing BTTA,which is primarily attributed to the differential response behaviors of plastic deformation mechanism operation and strain accommodation to BTTA in the upper regions among these sheets.Given that BTTA is>0°butslip dominates the plastic deformation.The positive correlation between formability gain and BTTA benefits greatly from the continuously enhanced initial basal slip ability and the reduced orientation hardening rate.When BTTA is≥60°butslip,along with the orientation softening for basal slip,promotes the formability improvement.Once BTTA approaches 90°,the profuse formation of{10-12}tension twin is a main contribution to the formability increment.Additionally,the evolution pattern of thickness-direction strain accommodation capability(ravg.value)with increasing BTTA is completely consistent with the I.E.value.Specially,due to the strong initial basal slip ability,numerous tension twins with soft orientation for basal slip formed during the early forming stage,the continuous orientation softening for basal slip in matrix and the highest thickness-direction strain accommodation capability,the sheet with a BTTA of 60°shows the optimal RT formability manifested as an I.E.value of 7.6 mm which represents a∼217%enhancement compared to the initial sheet with a BTTA of 0°.This work deepens the understanding of tilting basal texture for optimizing formability and provides theoretical foundations for the reverse design and development of magnesium alloy sheets with high RT formability.
基金Sun Yat-sen University Cancer Center Youth Excellence Program(Project No.:PT2108040)。
摘要Objective:To explore the application effect of the intelligent blood collection system in the outpatient blood collection of cancer specialized hospitals,and to provide a basis for improving the quality of outpatient blood collection nursing and the medical experience of patients.Methods:136,274 blood specimens collected using the traditional manual blood collection mode from January to June 2020 were selected as the control group,and 176,989 blood specimens collected using the intelligent blood collection system from January to June 2021 were selected as the observation group.The blood collection process time,blood specimen quality,incidence of adverse events and patient satisfaction of the two groups were compared.Measurement data were expressed as x±s and analyzed by t-test.Counting data were expressed as cases(%),and theχ2test was used.A p value<0.05 was considered statistically significant.Results:The registration and number collection time,specimen submission time and total process time of the observation group were significantly shorter than those of the control group(p<0.001).The total error rate of blood samples decreased from 0.374%to 0.050%,and the error rate of blood collection tube usage decreased from 3.8%to 0.7%.The patient satisfaction rate increased from 88%to 96%,and the differences were statistically significant(p<0.05).Conclusion:The intelligent blood collection system can optimize the outpatient blood collection process,shorten the service duration,reduce the error rate of specimens,improve the efficiency of nursing and patient satisfaction,and has good application value in the outpatient blood collection management of tumor specialized hospitals.
摘要This study assessed the health‑related quality of life(HRQoL)of Chinese patients with mucopolysaccharidosis type Ⅱ(MPS Ⅱ)and explored key factors associated with HRQoL.A cross‑sectional survey was conducted in February 2023 through the China Rare Disease Alliance Cloud Service Platform,in which patients with MPS Ⅱ and their family members completed an online questionnaire collecting information on Pediatric Quality of Life Inventory(PedsQL)Version 4.0 scores,sociodemographic characteristics,and clinical features.Descriptive statistics were used to summarize patient characteristics and HRQoL levels,and multiple linear and logistic regression analyses were performed to identify factors influencing HRQoL.Data were obtained from 129 individuals across 22 regions in China,the majority of whom were boys(98%),with a mean age of 8.7 years.Initial symptoms appeared at approximately 2.5 years of age,yet diagnosis was often delayed by more than one year,and over half of the children(57%)had previously received an incorrect diagnosis.On average,nearly ten body systems were affected.Overall HRQoL was low,with a mean score of 30.08(standard deviation(SD)=19.51).Domain‑specific scores were 30.98 for daily activities,43.18 for emotional well‑being,24.73 for social functioning,and 20.89 for school participation,indicating substantial difficulties in performing routine tasks.Multiple linear regression(adjusted R²=0.381)showed that HRQoL significantly declined with increasing age(β=−2.000,P=0.003)and the presence of neurological or cognitive impairments(β=−12.798,P<0.001),whereas school attendance was a strong positive predictor of higher HRQoL(β=16.330,P<0.001).Overall,Chinese patients with MPS Ⅱ demonstrated markedly reduced HRQoL,particularly in cognitive and daily functioning domains,underscoring the need for improved clinical management and supportive strategies to enhance their well‑being.
摘要Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis of 197 patients undergoing prostate biopsy with prostate-specific antigens between 4 and 10 ng ml^?1 was conducted.Of these,47 patients were confirmed to have cancer,while the remaining 150 patients were diagnosed with benign prostate disease after examining biopsy pathology.Two multivariate logistic regression models were established including age,prostate volumes,freeotal prostate-specific antigen ratio,and prostate-specific antigen density using SPSS 19.0 to obtain the predicted probability and Logit P,and then,two receiver operating characteristic(ROC)curves were drawn to obtain the best cutoff value for prostate biopsy:one for the group of all the prostate cancers and one for the group of clinically significant prostate cancers.The best cutoff value for prostate biopsy was 0.25 from the multivariate logistic regression ROC curve model of all the prostate cancers,which gave a sensitivity of 75.4%and a specificity of 75.8%.The best cutoff value for prostate biopsy was 0.20 from the multivariate logistic regression model of clinically significant prostate cancers,which gave a sensitivity of 76.7%and a specificity of 80.1%.We identified the best cutoff values for prostate biopsy(0.25 for all prostate cancers and 0.20 for clinically significant prostate cancers)to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone.
摘要Objective:To address the poor prognosis of patients caused by the weak knowledge and non-standard operation of blood glucose management among non-endocrinology specialist nurses during the perioperative period,this study aims to establish a scientific and systematic structured training system.Through a training model that combines theory with practice,it aims to enhance the perioperative blood glucose management ability of nurses,improve the blood glucose control effect,and clinical outcomes of patients.Method:A mixed research method was adopted.The training theoretical framework was constructed through literature analysis.The weights of the course modules were determined by combining semi-structured interviews(n=35)and two rounds of Delphi expert inquiries(expert authority coefficient 0.89)(first-level indicator weights:theoretical foundation 0.25,skill operation 0.35,clinical application 0.28,emergency treatment 0.12).Finally,a structured training program containing 4 first-level indicators and 12 second-level indicators was formed.A total of 86 non-endocrinology specialist nurses(working years 2–15 years,average 6.8±3.2 years;professional titles:32 nurses,38 senior nurses,16 charge nurses)were selected by stratified random sampling and underwent a 4-week training.The training included theoretical lectures,scenario simulations,case studies,and bedside practical operations.After the training,the effects were comprehensively evaluated through theoretical assessments,operational scores,and patients’blood glucose monitoring data.Result:After the training,the standardized rate of perioperative blood glucose monitoring among nurses increased from 54.2%to 91.7%(p<0.001),the qualified rate of standardized insulin injection increased from 58.3%to 91.8%(p<0.001),and the average score of theoretical assessment increased from 62.5±8.3 points to 89.6±5.7 points(p<0.001).The preoperative blood glucose compliance rate of patients increased from 54.3%to 76.8%(p<0.001),the 24-hour blood glucose fluctuation range after surgery decreased from(5.8±1.6)mmol/L to(2.9±0.9)mmol/L(p<0.001),and the incidence of perioperative hypoglycemic events decreased from 8.0%to 2.0%(p=0.008).Multivariate analysis showed that nurses with a training duration of≥4 weeks had a 68%lower risk of postoperative infection in the patients under their charge(OR=0.32,95%CI 0.13–0.79).Conclusion:Structured training significantly enhances the perioperative blood glucose management ability of non-endocrinology specialist nurses and improves the clinical outcomes of patients.It is suggested that such training be incorporated into the compulsory content of nurses’continuing education,a regional homogeneous training and certification system be established,and patient-participatory evaluation tools and digital training platforms be developed to promote the continuous improvement of perioperative nursing quality.
基金financially supported by the National Natural Science Foundation of China(202102007,21978147 and 21935001)the Fundamental Research Funds for the Central Universities(buctrc202112)。
摘要Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reactions.Herein,the ultrasmall Ru nanoclusters(~0.9 nm)were successfully fabricated over P25 support with positive charged Ruδ+species at the interface.A new route was developed to achieve the furfural(FAL)to furfurylamine(FAM)by coupling the light-driven reductive amination and hydrogen transfer of ethanol over this type catalyst.Strikingly,the photocatalytic activity and selectivity are strongly dependent on the particle size and electronic structure of Ruthenium.The Ruδ+species at the interface promote the formation of active imine intermediates;moreover,the Ru nanoclusters facilitate the separation efficiency of electrons and holes as well as accelerate the further hydrogenation of imine intermediates to product primary amines.In contrast Ru particles in larger nanometer size facilitate the formation of the furfuryl alcohol and excessive hydrogenation products.In addition,the coupling byproducts can be effectively inhibited via the construction of sub-nanocluster.This study offers a new path to produce the primary amines from biomass-derived carbonyl compounds over hybrid semiconductor/metal-clusters photocatalyst via light-driven tandem catalytic process.
基金Supported by Guangdong Graduate Innovation Program Project:2017SFKC13。
摘要Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients with refractory peripheral facial paralysis were treated with the combination of warming-needle moxibustion and stuck-needle-pulling technique.The treatment was given once daily and there were 2 days at interval after consecutive 5 treatments.A total of 10 treatments made one course and consecutive 2 courses of treatment were required.Before and after treatment,HouseBrackmann(H-B)facial nerve grading scale score was adopted to evaluate the degree of facial paralysis in the patients and the clinical effect was assessed.Results:After treatment,the mean H-B score was higher than that before treatment in the patients,indicating a statistical significance(P<0.05).After treatment,of 33 cases,12 cases were cured,9 cases effective remarkably,8 cases effective and 4 cases no effect.The total effective rate was 87.88%.Conclusion:The combination treatment of warming-needle moxibustion and stuck-needle-pulling technique achieves a definite effect on refractory peripheral facial paralysis.