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Temperature-dependent pyrolysis product modulation driven by thermal pretreatment of Shendong coal 认领 引用
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作者 Luyao Qiang Boyang Bai +4 位作者 Ming Sun Dengmeng Song Boli Hou Ting Gao Xiaoxun Ma 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第3期111-126,共16页
The pyrolysis behavior of coal exhibits critical temperature dependence,necessitating structureactivity relationship studies across defined temperature ranges.In this work,structural evolution and pyrolysis characteri... The pyrolysis behavior of coal exhibits critical temperature dependence,necessitating structureactivity relationship studies across defined temperature ranges.In this work,structural evolution and pyrolysis characteristics of hydrothermally(SD-HTP)and methane thermally(SD-CH4)pretreated Shendong coal were investigated through XPS and 13C NMR analysis,coupled with temperature-resolved pyrolysis(400-700℃)using powder-particle fluidized bed and Py-GC/MS.The results indicated that the oxygen content of SD-HTP and SD-CH4 decreased from 16.26% in the raw coal to 13.95% and 12.48%,respectively,while the hydrogen content increased from 4.47% to 5.01% and 5.31%.Both pretreatment methods selectively decomposed oxygen-containing functional groups such as OH,C-O,and COOR,disrupting the cross-linked network.SD-HTP enhanced phenolic hydroxyl groups through ether bond conversion in particular.These structural modifications significantly modulated temperature-dependent hydrogen and oxygen migration and pyrolysis product distribution.By optimizing hydrogen redistribution and suppressing cross-linking reactions,the tar yield of SD-HTP and SD-CH4 at 600℃ increased to 10.54% and 10.01%,respectively,compared to 9.23% for SD coal,while pyrolytic water decreased to 2.7% and 2.20% from 2.97%.Above 600℃,pretreated tars exhibited enriched MAHs/BAHs but reduced PAHs,with prominent phenolic compound retention due to inhibited condensation.Subsequently,pretreated chars developed higher micro porosity,especially for the SD-HTP-600 char,the surface area increased from 3.65 to 6.26 m2·g-1,accelerating CO2 gasification reactivity via lowered CO evolution temperatures and increased yields.This study established a link between thermal pretreatment caused structural reorganization and optimized pyrolysis-gasification pathways for efficient low-rank coal valorization. 展开更多
关键词 Hydrothermal Methane-thermal Pyrolysis Casification
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Recent progress in high-strength Mg-Gd-based alloys:the role of heat treatments in controlling microstructures and mechanical properties 认领 引用
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作者 Linqing Pei Ming Sun +1 位作者 Meifeng He Yunhao Zhao 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第5期1339-1351,共13页
Lightweight and high-strength Mg-Gd magnesium(Mg)alloys have important application prospects in automotive,aerospace and military fields.Heat treatment is the most crucial method to improve service properties of Mg-Gd... Lightweight and high-strength Mg-Gd magnesium(Mg)alloys have important application prospects in automotive,aerospace and military fields.Heat treatment is the most crucial method to improve service properties of Mg-Gd alloys,such as room-temperature mechanical properties,high-temperature mechanical properties and creep resistance.In this paper,the recent research progress in heat treatment of Mg-Gd alloys is systematically reviewed.The heat treatment principles of Mg-Gd alloys are presented.The effects of solution,aging,homogenization and annealing heat treatments on microstructure and mechanical properties of conventionally prepared Mg-Gd alloys are summarized.Then the effects of heat treatment on microstructure and mechanical properties of Mg-Gd alloys prepared with additive manufacturing(AM)are briefly introduced.Finally,the future research direction of heat treatment of Mg-Gd alloys is prospected.This article will provide important reference for the development of high-strength Mg-RE alloys. 展开更多
关键词 Mg-Gd alloy Mg alloy Heat treatment Precipitates Mechanical properties Rare earths
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Hydrodynamics of the self propulsion of a three-dimensional bioinspired travelling wave plate in ground effect 认领 引用
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作者 Zhiqiang Xin Ming Sun Yiming Ren 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第6期241-256,共16页
In nature,some undulating propulsion organisms with broad pectoral fin utilize ground effect to swim near walls such as the seabed.Inspired by these organisms,the immersed boundary method was adopted to carry out a th... In nature,some undulating propulsion organisms with broad pectoral fin utilize ground effect to swim near walls such as the seabed.Inspired by these organisms,the immersed boundary method was adopted to carry out a three-dimensional numerical simulation of a self-propelled wave plate in ground effect.We had taken into account the three-dimensional flow characteristics of the wavy plate from aspects such as the initial height from the ground,the undulating parameters,and the geometric features of the body.It is found that the undulating rules of travelling wave plate in ground effect need to be controlled in order to obtain better motion performance in ground effect,and the wavy plate can enhance the thrust force rather than the lift force compared with flapping propulsion.The characteristics of the wake vortex structure of the wavy plate change with the undulating amplitude.The optimal fluctuation amplitude enables the plate to achieve a relatively good propulsion speed.Compared with other amplitudes,the swimming efficiency can be increased by 66%at the optimal fluctuation amplitude.Increasing the undulating frequency does not alter the structure of the wake vortices,but it results in a uniform enhancement of the wake vorticity intensity of the plate.When the frequency increases from 1.8 to 2.6,the cruising speed increases by 48%,and the swimming efficiency improves by 30%.For the three-dimensional shape,different shape characteristics also have an impact on it.The plate with larger aspect ratio has a higher speed and a higher swimming efficiency under the same undulating parameters. 展开更多
关键词 Travelling wave plate Self-propelled swimming Ground effect Vorticity dynamics Immersed boundary method
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Fine-tuning Atmospheric Parameters for Improving ENSO Simulation in the Zebiak–Cane Model 认领 引用
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作者 Xiaojun WEI Lin CHEN +2 位作者 Ming SUN Ruihuang XIE Rong-Hua ZHANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2026年第2期420-435,I0022-I0026,共16页
The Zebiak–Cane(ZC) model, renowned as a coupled ocean-atmosphere model specifically designed to simulate and predict El Niño-Southern Oscillation(ENSO), is an indispensable tool for ENSO studies. However, the o... The Zebiak–Cane(ZC) model, renowned as a coupled ocean-atmosphere model specifically designed to simulate and predict El Niño-Southern Oscillation(ENSO), is an indispensable tool for ENSO studies. However, the original ZC model exhibits certain biases in reproducing the ENSO–related sea surface temperature anomalies and heating anomalies, limiting its broader applicability. To improve the accuracy of ENSO simulation, we propose a modified ZC model based on Xie et al.(2015), named the MZC_XJH model, through refining the heating parameterization scheme. The performance in simulating the nonlinear SST–precipitation relationship in the MZC_XJH model is firstly elaborated. Then, we investigate the impacts of three key atmospheric parameters on ENSO simulation by conducting experiments with the MZC_XJH model. Through assessing the performance in simulating five fundamental ENSO metrics(amplitude, periodicity,seasonality, diversity, and skewness), we uncover that the sensitivities of simulated ENSO behaviors to different parameters are distinct. Moreover, we explain why a particular parameter greatly affects some simulated ENSO behaviors while others exert minor influence. We also reveal that the nonlinear effect due to the covariation of multi-parameters on ENSO simulation warrants careful consideration when tuning multi-parameters synchronously. Lastly, we present an updated version of the MZC_XJH model, in which some biases have been mitigated but some remain obvious. Although there are no universally optimal parameters that would ensure flawless performance in simulating every aspect of ENSO, this study provides a valuable reference for tuning atmospheric parameters in the MZC_XJH model, rendering the MZC_XJH model applicable to some research objectives. 展开更多
关键词 ENSO Zebiak–Cane model SST–precipitation relationship parameterization schemes
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Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology 认领 引用
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作者 Zhixin Lim Ha Linh Nguyen +12 位作者 Yuanyuan Zeng Qigngyue Qu Yan Le Ming Sun Xiaoyu Wang Hong Zhu Yuchen Qian Saboor Saeed Huaizhi Wang Dazhong Rong Yueming Wang Xuhong Zhang Shaohua Hu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第7期1650-1674,共25页
The central resident immune system,commonly known as the glial system,comprises various glial cells that play a critical role in neuropsychiatric disorders.However,a systematic review exploring the relationships betwe... The central resident immune system,commonly known as the glial system,comprises various glial cells that play a critical role in neuropsychiatric disorders.However,a systematic review exploring the relationships between the life cycles and daily rhythms of these immune cells and the pathological features of neuropsychiatric disorders is lacking.These immune cells exhibit unique developmental origins and circadian characteristics,resulting in rhythmic variations in functions such as phagocytosis,immune clearance,neurogenesis,and neurotransmitter recycling.These properties are crucial for understanding the pathological mechanisms underlying developmental disorders like major depressive disorder,autism spectrum disorder,and schizophrenia,as well as age-related conditions such as Alzheimer’s and Parkinson’s diseases.The daily rhythms of these immune cells correlate with diurnal variations in emotion,cognition,and motor function,involving shared processes like oxidative stress and neuroinflammation.This article systematically reviews the composition,life cycle changes,and circadian characteristics of central immune cells,highlighting their roles in neuropsychiatric diseases. 展开更多
关键词 Central resident immunity Life cycle Circadian rhythm Neuropsychiatric disorders Development Aging
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Prediction of Liquid Film Development and Erosion-Corrosion Risk in Elbowed Pipeline Systems 认领 引用
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作者 Penghui Zhang Nan Lin +4 位作者 Yang Wang Ming Sun Sixi Zha Zongjie Zhou Chenglin Li 《Fluid Dynamics & Materials Processing》 EI 2026年第5期258-275,共18页
Erosion-corrosion in refining and chemical plant pipelines remains a persistent integrity concern,particularly in straight sections located downstream of elbows,which are rarely prioritized in inspection programs that... Erosion-corrosion in refining and chemical plant pipelines remains a persistent integrity concern,particularly in straight sections located downstream of elbows,which are rarely prioritized in inspection programs that typically focus on elbows and tees despite their well-known vulnerability.In these downstream regions,developing flow structures can sustain wall impingement and liquid film formation,leading to progressive material loss that is often underestimated in practice.This work examines a representative industrial pipeline through a combined approach based on computational fluid dynamics(CFD)simulations and controlled experimental validation to resolve the hydrodynamic behavior in the straight pipe section downstream of an elbow under different operating conditions.The objective is to identify the governing parameters controlling liquid film development and to support predictive assessment of erosion-corrosion risk in overlooked pipeline regions.The analysis shows that liquid film length is primarily controlled by flow velocity,water volume fraction,and the length of the upstream vertical section.When the upstream vertical pipe length is below 1 m,the flow remains highly unstable after the elbow,promoting intensified wall interaction and increased erosion susceptibility.For larger upstream lengths,the liquid film length exhibits an approximately linear increase with water volume fraction.Its dependence on flow velocity is non-monotonic,increasing at lower velocities,reaching a maximum at 6 m/s,and decreasing thereafter.Building on these trends,a predictive correlation is developed for liquid film length as a function of water volume fraction,flow velocity,and pipe length.The resulting model provides a quantitative basis for identifying erosion-corrosion risk in straight pipe sections and supports more targeted inspection and integrity management strategies in industrial pipeline systems. 展开更多
关键词 Numerical simulation fluid dynamics corrosion location prediction
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QTL detection and candidate gene identification for prostrate growth habit in interspecific crosses of wild chrysanthemum (Chrysanthemum yantaiense × C.indicum) 认领 引用 被引量：1
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作者 Dawei Li Yuxian Xu +8 位作者 Tongjun Zhou Yuchao Tang Hai Li Ziyu Guo Yilin Liang Yuxin Wang Yuyuan Chen Ming Sun Xuehao Fu 《Horticulture Research》 SCIE CSCD 2025年第8期234-245,共12页
The prostrate growth habit is an important ornamental trait in ground-cover chrysanthemum,offering high aesthetic value,strong lodging resistance,and excellent landscape greening capability.However,the genetic basis u... The prostrate growth habit is an important ornamental trait in ground-cover chrysanthemum,offering high aesthetic value,strong lodging resistance,and excellent landscape greening capability.However,the genetic basis underlying this trait in chrysanthemum remains largely unclear.In this study,we utilized the prostrate-type Chrysanthemum yantaiense(tetraploid),the erect-type C.indicum(tetraploid),and their 199 F1 hybrid progenies to construct a high-density genetic linkage map through genotyping-by-sequencing.The biparental linkage maps included 4614 and 5180 SNP markers,with an average marker distance of 0.84 and 0.73 cM,respectively.After four years of phenotypic evaluation and one year of dynamic trait measurement in progenies for traits related to prostrate growth habit,we confirmed a stable quantitative trait locus(QTL)located on LG11 among co-localized QTLs using KASP markers.This QTL explained up to 20.13% of the phenotypic variation.As a result,a total of 44 genes were identified as candidate due to their tightly linkage with the peak QTL marker,Tag16173.Further phytohormone measurement,gene expression analysis,and transgenic studies confirmed that one of these candidates,the D type cyclin-encoding gene CyCYCD3;1,played a key role in the formation of prostrate growth habit in C.yantaiense.Our results not only enhance the understanding of the molecular mechanisms behind prostrate growth habit but also provide valuable molecular markers for improving plant architecture-related traits in chrysanthemum breeding. 展开更多
关键词 Candidate gene identification Wild chrysanthemum QTL detection ornamental trait f hybrid progenies landscape greening prostrate growth habit Interspecific crosses
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Evaluating vector winds over eastern China in 2022 predicted by the CMA-MESO model and ECMWF forecast 认领 引用 被引量：1
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作者 Fang Huang Mingjian Zeng +4 位作者 Zhongfeng Xu Boni Wang Ming Sun Hangcheng Ge Shoukang Wu 《Atmospheric and Oceanic Science Letters》 CSCD 2025年第4期41-47,共7页
Vector winds play a crucial role in weather and climate,as well as the effective utilization of wind energy resources.However,limited research has been conducted on treating the wind field as a vector field in the eva... Vector winds play a crucial role in weather and climate,as well as the effective utilization of wind energy resources.However,limited research has been conducted on treating the wind field as a vector field in the evaluation of numerical weather prediction models.In this study,the authors treat vector winds as a whole by employing a vector field evaluation method,and evaluate the mesoscale model of the China Meteorological Administration(CMA-MESO)and ECMWF forecast,with reference to ERA5 reanalysis,in terms of multiple aspects of vector winds over eastern China in 2022.The results show that the ECMWF forecast is superior to CMA-MESO in predicting the spatial distribution and intensity of 10-m vector winds.Both models overestimate the wind speed in East China,and CMA-MESO overestimates the wind speed to a greater extent.The forecasting skill of the vector wind field in both models decreases with increasing lead time.The forecasting skill of CMA-MESO fluctuates more and decreases faster than that of the ECMWF forecast.There is a significant negative correlation between the model vector wind forecasting skill and terrain height.This study provides a scientific evaluation of the local application of vector wind forecasts of the CMA-MESO model and ECMWF forecast. 展开更多
关键词 Model evaluation Vector winds CMA-MESO ECMWF Forecasting skill
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Efficiently boosting oxygen reduction activity of MnO2 with tailored surface oxygen vacancies by ball milling 认领 引用
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作者 Danlin Wang Jiajin Luo +9 位作者 Junning Li Yuyang Zheng Yajing Su Zhuoli Deng Gao Cheng Yingying Xu Ying Wu Yuanhong Zhong Ming Sun Lin Yu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2025年第11期58-65,共8页
Oxygen vacancy engineering is a valid strategy to boost the oxygen reduction reaction(ORR) performance of nanostructured electrocatalysts.Current methods for generating surface oxygen vacancies(Vos) in nanostructured ... Oxygen vacancy engineering is a valid strategy to boost the oxygen reduction reaction(ORR) performance of nanostructured electrocatalysts.Current methods for generating surface oxygen vacancies(Vos) in nanostructured MnO2 is mostly lab-scale,which cannot meet the requirement of large-scale production.Herein,we employed a mechanochemical method of ball milling to introduce surface Vos into the β-MnO2 nanoparticles.The ball milling process generated abundant surface Vos,which significantly facilitated the adsorption and activation of O2.Consequently,the ORR performance of ball-milled β-MnO2 was markedly boosted by varying the ball milling time.As an air cathode catalyst for zinc-air battery(ZAB),the β-MnO2 ball-milled for 4 h displayed a high specific capacity of 804 mA·h·g-1 and excellent cycling over 500 h at 5 mA·cm-2,which were superior than those of pristine β-MnO2-based ZAB.Our work offers a feasible strategy to enhance electrocatalytic ORR performance of MnO2,which shows significant potential for large-scale production of efficient ORR electrocatalysts. 展开更多
关键词 MnO2catalysts Ball milling Oxygen vacancy Electrochemistry Oxygen reduction reaction Zinc-air battery
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Topological transmission and topological corner states combiner in all-dielectric honeycomb valley photonic crystals 认领 引用
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作者 Ming Sun Xiao-Fang Xu +2 位作者 Yun-Feng Shen Ya-Qing Chang Wen-Ji Zhou 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第3期424-431,共8页
We study the topological states(TSs)of all-dielectric honeycomb valley photonic crystals(VPCs).Breaking the space inversion symmetry of the honeycomb lattice by varying the filling ratio of materials for circular ring... We study the topological states(TSs)of all-dielectric honeycomb valley photonic crystals(VPCs).Breaking the space inversion symmetry of the honeycomb lattice by varying the filling ratio of materials for circular ring dielectric columns in the unit cell,which triggers topological phase transitions and thus achieves topological edge states(TESs)and topological corner states(TCSs).The results demonstrate that this structure has efficient photon transmission characteristics and anti-scattering robustness.In particular,we have found that changing the type of edge splicing between VPCs with different topological properties produces a change in the frequency of TCSs,and then based on this phenomenon,we have used a new method of adjusting only the type of edge splicing of the structure to design a novel TCSs combiner that can integrate four TCSs with different frequencies.This work not only expands the variety and number of unexplored TCSs that may exist in a fixed photonic band gap and can be rationalized to be selectively excited in the fixed configuration.Our study provides a feasible pathway for the design of integrated optical devices in which multiple TSs coexist in a single photonic system. 展开更多
关键词 valley photonic crystals topological phase transitions topological edge states topological corner states combiner
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A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses 认领 引用
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作者 Lanfang Zhu Jingtao Pu +7 位作者 Yufen Tao Lei Shi Shuyuan Liu Xinwen Zhang Weipeng Liu Ming Sun Yufeng Yao Li Shi 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第9期1102-1126,共25页
Objective:Cervical cancer caused by persistent high-risk human papillomavirus(hrHPV)infection remains a leading cause of cancer-related mortality in women.As prophylactic HPV vaccines cannot eliminate existing infecti... Objective:Cervical cancer caused by persistent high-risk human papillomavirus(hrHPV)infection remains a leading cause of cancer-related mortality in women.As prophylactic HPV vaccines cannot eliminate existing infections,developing therapeutic vaccines targeting HPV E6/E7 oncoproteins is critical for reversing precancerous lesions.This study aimed to design a novel multiepitope vaccine against HPV16,incorporating newly identified immunodominant epitopes and evaluating the therapeutic efficacy.Methods:The multi-epitope vaccine HSP70-12P was bioinformatically designed to include cytotoxic T lymphocyte(CTL)and helper T lymphocyte(HTL)epitopes from HPV16 E6/E7,which were fused to the C-terminal domain(residues 359±610)of Mycobacterium tuberculosis HSP70 as an adjuvant.Two formulations were used,as follows:(1)protein-based Pro-HSP70-12P;and(2)DNA-based DNA-HSP70-12P.Therapeutic efficacy was evaluated in TC-1 tumor-bearing mouse models.Tumor regression,survival rates,and immune correlates(T cell responses and cytokine profiles)were assessed.Immunodominant epitopes were identified using ELISpot.Results:The Pro-HSP70-12P protein vaccine induced strong immune responses and provided lasting antitumor protection.The vaccine activated cell-mediated immunity and stimulated effector memory T cells in the HPV-16-related tumor mouse model,resulting in strong tumor clearance effects.Pro-HSP70-12P demonstrated superior performance compared to the DNA-HSP70-12P vaccine,achieving complete regression of small tumors(diameter<2 mm)with a single dose and conferring long-lasting protection in TC-1 rechallenge experiments.Three novel immunodominant epitopes were identified(E6-38-45,E6-124-132,and E7-50-57).The E6 epitopes address a critical gap in E6-targeted vaccine design.Conclusions:The multi-epitope protein vaccine,Pro-HSP70-12P,represents a potent therapeutic candidate against HPV-driven malignancies,which has the capacity to induce tumor regression and long-term immunity.These findings support further clinical development. 展开更多
关键词 Human papillomavirus cervical cancer therapeutic vaccine E6/E7 oncoproteins immuno-oncological therapy
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Integrated CO2capture and electrochemical reduction:From mechanism understanding to gas diffusion electrode and catalyst design 认领 引用
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作者 Xinyu Zhang Ming Sun +3 位作者 Yao Wang Hanya Zhang Juan Du Aibing Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第7期81-100,共20页
Integrating the CO2capture process with the CO2electrochemical reduction process into a single system can eliminate the need for storage and transportation following CO2capture.This integrated process offers ... Integrating the CO2capture process with the CO2electrochemical reduction process into a single system can eliminate the need for storage and transportation following CO2capture.This integrated process offers several advantages over multi-step cascade processes,including reduced costs and enhanced CO2utilization.However,the integrated CO2capture and electrochemical reduction(CCER)process encounters several challenges,including the low CO2adsorption performance of the gas diffusion electrode(GDE)and catalyst,as well as the poor activity and selectivity of the catalyst for the electrochemical reduction of CO2.This review aims to systematically summarize the fundamentals of the CCER process.Based on an in-depth understanding of the CO2mass transfer,adsorption,and electrochemical reduction processes,GDE design strategies based on the modulation of wettability and structure are discussed to enhance the CO2capture capability at the GDE level.At the catalyst level,catalyst design strategies based on the introduction of CO2capture sites and the construction of CO2mass transfer channels were analyzed,and catalyst design strategies for enhanced CO2capture were proposed.This review summarizes the most common catalysts for CO2electrochemical reduction,such as Ni-based,Bi-based,and Cubased catalysts,and analyzes their design strategies based on reaction pathways for generating specific products.Finally,the problems and challenges of the CCER process are summarized and proposed,which provide ideas for the further application of this technology in the future. 展开更多
关键词 CO2capture Electrochemical reduction Gasdiffusion electrode Catalyst Application
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分层次多阶段的产教融合数据库课程体系建设 认领 引用 被引量：2
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作者 孙明 夏宇昂 周毅 《计算机教育》 2025年第10期57-62,共6页
针对国内高校数据库课程侧重应用和开发,忽略数据库系统实现能力培养的问题,依托“教育部—华为智能基座”虚拟教研室,提出深度融入华为openGauss数据库的分层次、多阶段、逐级挑战的产教融合数据库课程体系,介绍相应的进阶式六阶段混... 针对国内高校数据库课程侧重应用和开发,忽略数据库系统实现能力培养的问题,依托“教育部—华为智能基座”虚拟教研室,提出深度融入华为openGauss数据库的分层次、多阶段、逐级挑战的产教融合数据库课程体系,介绍相应的进阶式六阶段混合教学方法和逐级挑战的实验体系,最后说明教学成效。 展开更多
关键词 智能基座 虚拟教研室 数据库 产教融合 课程体系建设
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Recent developments and applications on high-performance cast magnesium rare-earth alloys 认领 引用 被引量：105
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作者 Guohua Wu Cunlong Wang +1 位作者 Ming Sun Wenjiang Ding 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第1期1-20,共20页
During the past decades,with the increasing demands in lightweight structural materials,Mg alloys with low density and high performance have been extensively investigated and partly applied in some industries.Especial... During the past decades,with the increasing demands in lightweight structural materials,Mg alloys with low density and high performance have been extensively investigated and partly applied in some industries.Especially when rare earth(RE)elements are added as major alloying elements to Mg alloys,the alloy strength and creep resistance are greatly improved,which have promoted several series of Mg-RE alloys.This paper reviews the progress and developments of high-performance Mg-RE alloys in recent years with emphasis on cast alloys.The main contents include the alloy design,melt purification,grain refinement,castability,novel liquid casting and semisolid forming approaches,and the industrial applications or trials made of Mg-RE alloys.The review will provide insights for future developments of new alloys,techniques and applications of Mg alloys. 展开更多
关键词 Magnesium alloys Rare-earth elements High-performance Developments Applications Cast
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Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis 认领 引用 被引量：22
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作者 Peng Deng Ming Sun +4 位作者 Wen-Yan Zhao Bin Hou Kai Li Tao Zhang Feng Gu 《World Journal of Gastroenterology》 SCIE CAS 2021年第6期487-500,共14页
BACKGROUND Gastric cancer(GC)is a prevalent malignancy,leading to a high incidence of cancer-associated death.Cisplatin(DDP)-based chemotherapy is the principal therapy for clinical GC treatment,but DDP resistance is ... BACKGROUND Gastric cancer(GC)is a prevalent malignancy,leading to a high incidence of cancer-associated death.Cisplatin(DDP)-based chemotherapy is the principal therapy for clinical GC treatment,but DDP resistance is a severe clinical challenge and the mechanism remains poorly understood.Circular RNAs(circRNAs)have been identified to play crucial roles in modulating the chemoresistance of gastric cancer cells.AIM To explore the effect of circVAPA on chemotherapy resistance during GC progression.METHODS The effect of circVAPA on GC progression and chemotherapy resistance was analyzed by MTT assay,colony formation assay,Transwell assay,wound healing assay,and flow cytometry analysis in GC cells and DDP resistant GC cell lines,and tumorigenicity analysis in nude mice in vivo.The mechanism was investigated by luciferase reporter assay,quantitative real-time PCR,and Western blot analysis.RESULTS CircVAPA expression was up-regulated in clinical GC tissues compared with normal samples.CircVAPA depletion inhibited proliferation,migration,and invasion and increased apoptosis of GC cells.The expression of circVAPA,STAT3,and STAT3 downstream genes was elevated in DDP resistant SGC7901/DDP cell lines.CircVAPA knockdown attenuated the DDP resistance of GC cells.Mechanically,circVAPA was able to sponge miR-125b-5p,and miR-125b-5p could target STAT3 in the GC cells.MiR-125b-5p inhibitor reversed circVAPA depletion-enhanced inhibitory effect of DDP on GC cells,and STAT3 knockdown blocked circVAPA overexpression-induced proliferation of DDPtreated SGC7901/DDP cells.The depletion of STAT3 and miR-125b-5p inhibitor reversed circVAPA depletion-induced GC cell apoptosis.Functionally,circVAPA contributed to the tumor growth of SGC7901/DDP cells in vivo.CONCLUSION CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling.Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells.CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy. 展开更多
关键词 Gastric cancer Progression Chemoresistance CircVAPA miR-125b-5p STAT3
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Positive regulatory role of R2R3 MYBs in terpene biosynthesis in Lilium‘Siberia’ 认领 引用 被引量：18
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作者 Yanhong Guo Ziyu Guo +5 位作者 Jian Zhong Yilin Liang Yuan Feng Peng Zhang Qixiang Zhang Ming Sun 《Horticultural Plant Journal》 SCIE CAS CSCD 2023年第5期1024-1038,共15页
Terpenoids are the main components contributing to the fragrance of Lilium‘Siberia’,and LiTPS2 plays a critical role in the biosynthesis of monoterpenoids.Although the major terpene synthases in Lilium‘Siberia’hav... Terpenoids are the main components contributing to the fragrance of Lilium‘Siberia’,and LiTPS2 plays a critical role in the biosynthesis of monoterpenoids.Although the major terpene synthases in Lilium‘Siberia’have been identified,how these TPS genes are transcriptionally regulated remains elusive in this distinguished flower.This study aimed to identify transcription factors that regulate the terpene synthesis in Lilium,and disclose the related underlying transcriptional regulation mechanism.In this study,we identified three R2R3-MYB TFs—LiMYB1,LiMYB305 and LiMYB330,which were involved in regulating the biosynthesis of terpenes in Lilium‘Siberia’.Quantitative real-time PCR showed spatial and temporal expression patterns consistent with the emission patterns of terpene compounds.When LiMYB1,LiMYB305 and LiMYB330were overexpressed in flowers,the release of some main monoterpenes,such as linalool and ocimene,as well as the expression of TPS genes,especially for LiTPS2,were enhanced.A virus-induced gene silencing(VIGS)assay showed that silencing these three LiMYBs decreased the level of monoterpenes by down-regulating the expression of the TPS genes.The yeast one-hybrid and transient expression assays indicated that all three LiMYBs could bind to and activate the promoter of LiTPS2.Moreover,the yeast two-hybrid assay verified that LiMYB1 could interact with LiMYB308 and LiMYB330,indicating their synergistic roles in the regulation of floral terpene biosynthesis.In general,these results indicated that LiMYB1,LiMYB305,and LiMYB330 might play essential roles in terpene biosynthesis in Lilium and would provide a new perspective for the transcriptional regulation of volatile terpenes in flowers. 展开更多
关键词 Lilium R2R3-MYB Expression analysis Terpenes Regulation
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Paleogene Tectonic Evolution Controls on Sequence Stratigraphic Patterns in the Central Part of Deepwater Area of Qiongdongnan Basin, Northern South China Sea 认领 引用 被引量：20
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作者 Guangzeng Song Hua Wang +6 位作者 Huajun Gan Zhipeng Sun Xiaolong Liu Meng Xu Jinfeng Ren Ming Sun Di Sun 《Journal of Earth Science》 SCIE CAS CSCD 2014年第2期275-288,共14页
In active rift basins, tectonism is extremely important for sequence stratigraphic patterns, affecting both the sequence architecture and internal makeup. Sequence stratigraphic framework of a Paleogene rift successio... In active rift basins, tectonism is extremely important for sequence stratigraphic patterns, affecting both the sequence architecture and internal makeup. Sequence stratigraphic framework of a Paleogene rift succession in Qiongdongnan Basin, northern South China Sea, was built using seismic profiles, complemented by well logs and cores. One first-order and three second-order sequences were identified on the basis of basin-scale unconformities, and seven third-order sequences are defined by unconformities along the basin margins and correlative conformities within the central basin. Through unconformity analysis and backstripping procedure, the Paleogene synrift tectonic evolution of deep- water area of Qiongdongnan Basin was proved to be episodic, which can be divided into rifting stage-I, rifting stage-II and rifting stage-III. Episodic rifting resulted in the formation of various types of struc- tural slope break belts, which controlled different architectures and internal makeup of sequences. This study enhances the understanding of the control of tectonic evolution on sequence stratigraphic pat- terns and establishes relevant patterns in a typical rift basin, and further proposes the favorable sand- stone reservoirs developing in different sequence stratigraphic patterns, which will be pretty helpful for subtle pool exploration in deepwater area of petroliferous basins. 展开更多
关键词 South China Sea deepwater area tectonic evolution structural slope break belt se-quence stratigraphic pattern.
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Sedimentary Characteristics and Model of Gravity Flow Depositional System for the First Member of Upper Miocene Huangliu Formation in Dongfang Area, Yinggehai Basin, Northwestern South China Sea 认领 引用 被引量：15
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作者 Ming Sun Hua Wang +4 位作者 Jihua Liao Huajun Gan Jun Xiao Jinfeng Ren Shu'e Zhao 《Journal of Earth Science》 SCIE CAS CSCD 2014年第3期506-518,共13页
The gravity flow deposit were mainly developed in the lowstand systems tract（LST） of the first member of Upper Miocene Huangliu Formation（Ehl1） in Dongfang area, Yinggehai Basin, has become a valuable target for g... The gravity flow deposit were mainly developed in the lowstand systems tract（LST） of the first member of Upper Miocene Huangliu Formation（Ehl1） in Dongfang area, Yinggehai Basin, has become a valuable target for gas exploration and production. The gravity flow sedimentary characteristics of lithofacies associations, sedimentary texture, seismic facies and logging facies were described in detail on the basis of integrated analysis of cores, logging and seismic data. The sedimentary microfacies types composed of neritic sandbar, continental shelf mud, main channel, bifurcated or cross-cutting distributary channel, overspill, and natural levee are revealed under the constraint of high resolution sequence stratigraphic framework in the Ehl1. The gravity flow deposit system in the LST is divided into three evolution stages corresponding to periods of three parasequence sets. The gravity flow deposit was induced in the early LST, expanded rapidly in the middle LST and decreased slightly in the late LST. But its developing scale decreased sharply in the transgression systems tract（TST） and finally vanished in the highstand systems tract（HST）. This spatial evolution rule is constrained by the integrated function of sediments supply of the Vietnam Blue River in the LST, the development of local gradient change in sea floor（micro-topography, i.e., flexure slope break）, and the fall in relative sea level. On the basics of the deep study of the coupling relationship among the three main control factors, the sedimentary model is established as an optimal component of ＂source-channel-sink＂ for shallow marine turbidite submarine fan. 展开更多
关键词 Yinggehai Basin Dongfang area the first member of Upper Miocene Huangliu Formation（Ehl1） sedimentation characteristics gravity flow sedimentary model.
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Validation of a HRGC–ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma 认领 引用 被引量：9
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作者 Jiazhi Xu Weijing Guo +5 位作者 Linhuan Wei Yuan Gao Haijun Zhang Yichi Zhang Ming Sun Jiping Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第1期289-295,共7页
Short-chain chlorinated paraffins(SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/... Short-chain chlorinated paraffins(SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/serum, mainly due to the difficulty of sample preparation and quantitative analysis. A method using high resolution gas chromatography coupled with electron capture negative ionization low resolution mass spectrometry(HRGC–ECNI/LRMS) was developed and validated to measure SCCPs in human plasma. The pretreatment process included protein denaturation and lipid elimination, liquid–liquid extraction with a mixture of n-hexane/dichloromethane(1:1, V/V), and cleanup on a multilayer silica column. The blank controls, including procedural blank, vacuum blood collection tube blank, and instrumental blank, were the most pivotal points for the reliable analysis of SCCPs. The average value of procedural blanks was 9.0 ng/g; and the method detection limit(MDL), calculated as the sum of the average procedural blank value and 3 times of the standard deviation of the procedural blanks, was 12.6 ng/g plasma. The validated method was applied to measure the concentrations of the total SCCPs(∑ SCCPs) in50 plasma samples from a general population. The measured plasma concentrations of ∑SCCPs ranged from <MDL to 203 ng/g wet weight(ww), with an average value of 32.0 ng/g ww.The relative abundance profiles of SCCPs in plasma samples were dominated by C10- and C11-CP congener groups centered on Cl6–7. The developed method can be used for the comprehensive and large-scale investigation of SCCP levels in human plasma. 展开更多
关键词 Short-chain chlorinated paraffins sample preparation Quantitative analysis Human plasma
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A Duplex Real-Time PCR Assay for the Simultaneous Detection of Porcine Circovirus 2 and Circovirus 3 认领 引用 被引量：22
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作者 Xiangdong Li MingMing Qiao +1 位作者 Ming Sun Kegong Tian 《Virologica Sinica》 SCIE CAS CSCD 2018年第2期181-186,共6页
Porcine circoviruses(PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-i... Porcine circoviruses(PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-infections in clinical samples. Thus, it would be practical to develop a duplex PCR method to detect PCV2 and PCV3 simultaneously. In this study, specific primers and probes were designed to target PCV2 cap and PCV3 rep genes. A duplex real-time PCR method was then developed to detect the two viruses. The assay was found to be highly specific, sensitive, and reproducible for PCV2/3 without cross-reactions with other swine pathogens. The sensitivity of this assay was 2.9 copies for the PCV2 plasmid and 22.5 copies for the PCV3 plasmid. The established assay was then used to detect PCV2/3 infection in 340 clinical samples collected in the first half of 2017. The results showed that the co-infection rate of PCV2/3 in the samples was 27.6%. Our study provides an important tool that can be used to perform urgently needed surveys for the two porcine circoviruses to evaluate their impact on the swine industry. 展开更多
关键词 Porcine circovirus 2（PCV2） Porcine circovirus 3（PCV3） Co-infection Real-time PCR
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