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Multi-tissue analysis identifies mitochondrial genes in chicken aging-induced productivity decline 认领 引用
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作者 Mingyue Gao Junnan Zhang +7 位作者 Boxuan Zhang Xinwei Jiang Bowen Niu Conghao Zhong Fangren Lan Wenxin Zhang Ning Yang Congjiao Sun 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第3期1297-1314,共18页
Background Aging-related production decline is widely observed in poultry farming,making it challenging to prolong the laying cycle of hens.However,its genetic determinants remain unclear.This study aimed to systemati... Background Aging-related production decline is widely observed in poultry farming,making it challenging to prolong the laying cycle of hens.However,its genetic determinants remain unclear.This study aimed to systematically identify key genes associated with hens with age-related production decline and reveal dynamic changes in gene expression during tissue functional decline.Results This study integrated multi-tissue transcriptomic data from 216 samples obtained from Rhode Island Red laying hens,covering nine tissues(hypothalamus,pituitary,cecum,duodenum,liver,ovary,magnum,isthmus,and uterus)at three age points(50,70,and 100 weeks of age).Through comprehensive analysis,we identified 87 genes that showed significant changes across all nine tissues(|log2-fold change|>1,FDR<0.05)and 20 hub genes playing critical roles in mitochondrial and ribosome functions.In addition,we identified 106 differentially expressed genes(DEGs)with tissue-specific expression patterns and interaction networks.We further screened 51 genes that are associated with both the age-related production decline process and economically important traits in chickens.Finally,functional validation using a hydrogen peroxide-induced senescence model in DF-1 cells highlighted NDUFB9,a gene associated with mitochondrial respiratory chain complex I,as a potential anti-aging target.Conclusions This study provides a systematic multi-tissue transcriptomic framework for understanding aging-associated productivity decline in laying hens.Our findings highlight conserved mitochondrial and ribosomal dysfunction as key molecular features of age-related production decline and identify NDUFB9 as a potential anti-aging target,offering valuable insights for improving poultry longevity and production performance. 展开更多
关键词 Age-related genes Chicken Functional decline Mitochondrial dysfunction Multi-tissue RNA-seq
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A genome-wide association study of post-traumatic stress disorder in traumatised Chinese populations 认领 引用
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作者 Kunlin Zhang Mingyue Gao +6 位作者 Chengqi Cao Yuwei Han Ping Liu Yajie Bi Haibo Yang Ling Xu Li Wang 《General Psychiatry》 CAS CSCD 2026年第1期65-70,共6页
To the editor,Genome-wide association studies(GWASs)of post-traumatic stress disorder(PTSD)have been extensively performed in populations of European and African ancestry1 but remain largely unexplored for Chinese pop... To the editor,Genome-wide association studies(GWASs)of post-traumatic stress disorder(PTSD)have been extensively performed in populations of European and African ancestry1 but remain largely unexplored for Chinese populations.We report the first PTSD GW AS in two independent Chinese cohorts comprising 1223 trauma-exposed individuals(288 cases and 935 controls).Gene-set analysis was performed to explore the biological function and the mechanism of PTSD.Genome-wide association analysis identified a locus at 15q26.2(LINC00923,rs11854251) approaching genome-wide significance(p=3.88×10-8). 展开更多
关键词 gw Chinese populations genome wide association study linc post traumatic stress disorder mechanism gene set analysis biological function
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Integrated mRNA-seq and miRNA-seq analysis reveals miR-210a-5p regulates uterine aging in laying hens by targeting the RASL11B/Raf/MAPK pathway 认领 引用
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作者 Xiyu Zhao Xinyan Li +7 位作者 Wenxin Zhang Mingyue Gao Conghao Zhong Boxuan Zhang Congjiao Sun Yao Zhang Shunshun Han Huadong Yin 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第6期2658-2677,共20页
Background Uterine aging is a key factor contributing to the deterioration of egg quality and reproductive performance in laying hens.Despite its importance,the molecular mechanisms underlying uterine aging remain poo... Background Uterine aging is a key factor contributing to the deterioration of egg quality and reproductive performance in laying hens.Despite its importance,the molecular mechanisms underlying uterine aging remain poorly defined.This study aimed to characterize gene expression and regulatory changes associated with uterine aging in hens at different life stages.Results Transcriptomic Analysis of uterine tissue from hens aged 350,500,And 700 d revealed dynamic changes in gene expression patterns during aging.A significant upregulation of genes involved in cellular senescence was observed,including increased expression of the p53 signaling pathway And markers associated with inflammation And cell cycle arrest.The most notable changes occurred between 350 And 500 d of age,suggesting this as a critical window for the onset of uterine aging.MicroRNA sequencing identified miR-210a-5p as significantly reduced with age.Target prediction and experimental validation showed that miR-210a-5p directly suppresses the expression of RASL11B,a Ras-like small GTPase that activates the MAPK signaling pathway.In primary uterine epithelial cells,reduced miR-210a-5p levels led to elevated RASL11B expression,increased activation of B-Raf,MEK,and ERK proteins,and enhanced expression of aging-related genes and inflammatory factors.In contrast,overexpression of miR-210a-5p or inhibition of the MAPK pathway delayed senescence and reduced inflammatory signaling.RASL11B overexpression was sufficient to induce aging phenotypes,confirming its central role in promoting uterine cellular aging.Conclusions This study identifies a novel regulatory pathway in which miR-210a-5p modulates uterine aging through the RASL11B-MAPK signaling cascade.The findings provide mechanistic insight into age-related reproductive decline in hens and suggest that targeting this pathway may offer new strategies for maintaining uterine function and extending reproductive lifespan in poultry. 展开更多
关键词 Epithelial senescence Laying hen MAPK pathway MiR-210a-5p RASL11B Uterine aging
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Modulating intestinal mucus barrier for nanoparticles penetration by surfactants 认领 引用 被引量：5
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作者 Xin Zhang Wei Dong +7 位作者 Hongbo Cheng Meixia Zhang Yongqiang Kou Jian Guan Qiaoyu Liu Mingyue Gao Xiuhua Wang ShiruiMao 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2019年第5期543-551,共9页
Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However,intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetrati... Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However,intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore,in this study,taking fluorescent labeled PLGA(poly(lactic-co-glycolic acid)) nanoparticles as a tool,the influence of anionic and nonionic surfactants on mucus penetration ability of nanoparticles and their mucus barrier regulating ability were studied. The movement of PLGA nanoparticles in mucus was tracked by multiple particles tracking method(MPT).Alteration of mucus properties by addition of surfactants was evaluated by rheology and morphology study. Rat intestinal villus penetration study was used to further evaluate penetration enhancement of nanoparticles. The effective diffusivities of the nanoparticles in surfactants pretreated mucus were increased by 2–3 times and the mucus barrier regulating capacity was also surfactant type dependent. Sodium dodecyl sulfate(SDS) increased the complex viscosity and viscoelastic properties of mucus,but poloxamer presented a decreased trend. Tween 80 maintained the rheological property of the mucus. With the mucus barrier regulated by surfactants,the penetration of nanoparticles in intestinal villus was obviously increased. In summary,the mucus penetration ability of nanoparticles could be enhanced by altering mucus microenvironment with surfactants. Tween 80 which largely retains the original mucus rheology and morphology properties may be a promising candidate for facilitating nanoparticle penetration through the mucus barrier with good safety profile. 展开更多
关键词 Mucus barrier Mucus modulating agents Rheology PLGA nanoparticles Surfactants
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F127 assisted fabrication of Ge/r GO/CNTs nanocomposites with three-dimensional network structure for efficient lithium storage 认领 引用 被引量：5
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作者 Hui Gu Mingyue Gao +9 位作者 Kuan Shen Tianli Zhang Junhao Zhang Xiangjun Zheng Xingmei Guo Yuanjun Liu Fu Cao Hongxing Gu Qinghong Kong Shenglin Xiong 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第9期447-451,共5页
To solve the volume expansion and poor electrical conductivity of germanium-based anode materials,GeGO/CNTs nanocomposites with three-dimensional network structure are fabricated through the dispersion of polyethylene... To solve the volume expansion and poor electrical conductivity of germanium-based anode materials,GeGO/CNTs nanocomposites with three-dimensional network structure are fabricated through the dispersion of polyethylene-polypropylene glycol(F127)and reduction of hydrogen.An interesting phenomenon is discovered that F127 can break GeO2polycrystalline microparticles into 100 nm nanoparticles by only physical interaction,which promotes the uniform dispersion of GeO2in a carbon network structure composed of graphene(rGO)and carbon nanotubes(CNTs).As evaluated as anode material of Lithium-ion batteries,GeGO/CNTs nanocomposites exhibit excellent lithium storage performance.The initial specific capacity is high to 1549.7 mAh/g at 0.2 A/g,and the reversible capacity still retains972.4 mAh/g after 100 cycles.The improved lithium storage performance is attributed to that Ge nanoparticles can effectively slow down the volume expansion during charge and discharge processes,and threedimensional carbon networks can improve electrical conductivity and accelerate lithium-ion transfer of anode materials. 展开更多
关键词 F127 assisted fabrication GeGO/CNTs nanocomposites Three-dimensional carbon network Lithium-ion batteries Cycle stability
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Expression model for multiple relationships in the ontology of traditional Chinese medicine knowledge 认领 引用 被引量：1
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作者 Mingyue Gao Lepeng Wang Meng Cui 《Journal of Traditional Chinese Medical Sciences》 CAS 2016年第1期59-65,共7页
Objective:To explore multiple relationships in traditional Chinese medicine(TCM)knowledge by comparing binary and multiple relationships during knowledge organization.Methods:Characteristics of binary and multiple sem... Objective:To explore multiple relationships in traditional Chinese medicine(TCM)knowledge by comparing binary and multiple relationships during knowledge organization.Methods:Characteristics of binary and multiple semantic relationships as well as their associations are described.A method to classify multiple relationships based on the involvement of time is proposed and theoretically validated using examples from the ancient TCM classic Important Formulas Worth a Thousand Gold Pieces.The classification includes parallel multiple relationships,restricted multiple relationships,multiple relationships that involve time,and multiple relationships that involve time restriction.Next,construction of multiple semantic relationships for TCM concepts in each classification using Protege,an ontology editing tool is described.Results:Protege is superior to a binary relationship and less than ideal with multiple relationships during the constitution of concept relationships.Conclusion:When applied in TCM,the semantic relationships constructed by Protege are superior than those constructed by correlation and/or attribute relationships,but less ideal than those constructed by the human cognitive process. 展开更多
关键词 Multiple relationships Ontology Expression model In traditional Chinese medicine knowledge
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Electrically reconfigurable miniaturized spectrometers based on nano-kirigami metasurfaces 认领 引用
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作者 QINGLIANG JIAO YONGYUE ZHANG +8 位作者 YANG XU MEIHUA NIU YANZHONG WANG YUANYUAN HAN MINGYUE GAO XIAORONG HONG QINGHUA LIANG CHANG-YIN JI JIAFANG LI 《Photonics Research》 SCIE EI CAS CSCD 2026年第5期2170-2179,共10页
Computational spectrometers offer miniaturization potential but face the spatial uniformity requirement of incident light and trade-offs between footprint and performance.Here we report a nano-kirigami spectrometer ac... Computational spectrometers offer miniaturization potential but face the spatial uniformity requirement of incident light and trade-offs between footprint and performance.Here we report a nano-kirigami spectrometer achieving~5 nm resolution within a 2.5 μm×2.5 μm footprint.The device uses voltage-controlled deformation of Au-SiO2-Si trilayer structures with Archimedean spiral patterns,enabling dynamic spectral encoding through 2D-to-3D morphological transitions. 展开更多
关键词 miniaturization voltage controlled deformation dynamic spectral encoding spectrometer archimedean spiral patternsenabling nano kirigami Au SiO Si trilayer structures computational spectrometers
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Growing Co–Ni–Se nanosheets on 3D carbon frameworks as advanced dual functional electrodes for supercapacitors and sodium ion batteries 认领 引用 被引量：8
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作者 Mingyue Gao Yanchun Xue +7 位作者 Yutang Zhang Chengxing Zhu Haiwei Yu Xingmei Guo Shasha Sun Shenglin Xiong Qinghong Kong Junhao Zhang 《Inorganic Chemistry Frontiers》 SCIE EI 2022年第15期3933-3942,共10页
The reasonable design of electrode materials is crucial for tuning the electrochemical performances of advanced energy storage systems.Co–Ni–Se nanosheets uniformly growing on a butterfly-wing-derived carbon framewo... The reasonable design of electrode materials is crucial for tuning the electrochemical performances of advanced energy storage systems.Co–Ni–Se nanosheets uniformly growing on a butterfly-wing-derived carbon framework(Co–Ni–Se/BWCF)with strong anchoring are devised and prepared by a microwave treatment–ion exchange–chemical etching–hydrothermal selenization technique.Benefiting from its multi-components and unique structure,Co–Ni–Se/BWCF-160 exhibits excellent supercapacitor and sodium storage performances as self-supporting electrodes. 展开更多
关键词 co ni se nanosheets microwave treatment ion exchange chemical etching hydrothermal selenization techniquebenefiting sodium storage performances tuning electrochemical performances design electrode materials advanced energy storage systemsco ni se nanosheets sodium ion batteries supercapacitors
Retinoic acid ameliorates high-fat diet-induced liver steatosis through Sirt1 认领 引用 被引量：10
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作者 Chao Geng Haifeng Xu +8 位作者 Yinliang Zhang Yong Gao Meixia Li Xiaoyan Liu Mingyue Gao Xiaojuan Wang Xiaojun Liu Fude Fang Yongsheng Chang 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第11期1234-1241,共8页
In this study, treatment of C57BL/6J （wild type, WT） mice fed a high-fat diet （HFD） with retinoic acid （RA） decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis,... In this study, treatment of C57BL/6J （wild type, WT） mice fed a high-fat diet （HFD） with retinoic acid （RA） decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular triglyceride and serum alanine transaminase （ALT） and aspartate aminotransferase （AST） concentrations. Moreover, RA treatment improved glucose tolerance and insulin sensitivity in WT mice fed a HFD. However, these RA-induced effects in WT mice fed a HFD were alleviated in liver specific Sirtuin 1 （Sirtl） deficient （LKO）mice fed a HFD. Furthermore, RA also could not improve glucose tolerance and insulin sensitivity in LKO mice fed a HFD. The mechanism studies indicated that RA indeed increased the expression of hepatic S irtl and superoxide dismutase 2 （Sod2）, and inhibited the expression of sterol regulatory element binding protein 1 c （Srebp- 1 c） in WT mice in vivo and in vitro. RA decreased mitochondrial reactive oxygen species （ROS） production in WT primary hepatocytes and increased mitochondrial DNA （mtDNA） copy number in WT mice liver. However, these RA-mediated molecular effects were also abolished in the liver and primary hepatocytes from LKO mice. In summary, RA protected against HFD-induced hepatosteatosis by decreasing Srebp-1 c expression and improving antioxidant capacity through a S irt 1-mediated mechanism. 展开更多
关键词 retinoic acid Sirtl non-alcoholic fatty liver disease lipid metabolism oxidative stress
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沉默circXPO1抑制肝癌细胞恶性生物学行为 认领 引用 被引量：1
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作者 刘杜先 张杰东 +6 位作者 付鲁渝 熊志强 龚程 张小雅 高明悦 孟俊宏 刘兰侠 《中华细胞与干细胞杂志（电子版）》 2024年第3期159-166,共8页
目的探讨circXPO1对肝癌细胞恶性生物学行为的影响及分子机制。方法RT-qPCR检测肝癌组织及癌旁组织中circXPO1和miR-195-5p的表达水平,并分析circXPO1表达水平与肝癌患者临床病理特征的相关性;将肝癌HCC9204细胞分别转染si-circXPO1、si... 目的探讨circXPO1对肝癌细胞恶性生物学行为的影响及分子机制。方法RT-qPCR检测肝癌组织及癌旁组织中circXPO1和miR-195-5p的表达水平,并分析circXPO1表达水平与肝癌患者临床病理特征的相关性;将肝癌HCC9204细胞分别转染si-circXPO1、si-NC、miR-195-5p mimic、miR-NC、si-circXPO1和miR-195-5p Inhibitor、si-circXPO1和anti-miR-NC后,MTT法和克隆形成实验检测细胞增殖,流式细胞术检测细胞凋亡,划痕实验检测细胞划痕愈合率,双荧光素酶报告实验检测circXPO1和miR-195-5p的靶向关系。构建裸鼠移植瘤模型,验证circXPO1对肝癌HCC9204细胞体内生长的影响。两组间比较采用配对样本t检验或独立样本t检验。结果与癌旁组织比较,肝癌组织中circXPO1呈高表达(2.14±0.30比0.87±0.13),miR-195-5p呈低表达(0.46±0.08比1.12±0.17),且circXPO1表达水平与肝癌的肿瘤大小、TNM分期和淋巴结转移有关(P均<0.05)。与si-NC或miR-NC比较,si-circXPO1和miR-195-5p mimic中HCC9204细胞增殖抑制率[(56.63±2.13)%比(0.00±0.00)%、(42.93±1.52)%比(0.00±0.00)%]、凋亡率[(23.91±1.21)%比(7.44±0.74)%、(20.02±0.84)%比(7.40±0.55)%]升高,划痕愈合率[(24.02±1.55)%比(65.54±2.53)%、(34.95±1.69)%比(65.66±2.68)%]和克隆形成数[(53.67±2.16)比(122.11±5.74)个、(72.44±3.69)比(120.56±8.00)个]、侵袭细胞数[(30.92±5.01)比(83.06±7.54)个、(32.05±4.66)比(85.43±8.17)个]及裸鼠移植瘤体积与质量降低(P均<0.05)。circXPO1靶向调控miR-195-5p(0.45±0.05比1.03±0.13,P<0.05);与si-circXPO1+anti-miR-NC比较,si-circXPO1+miR-195-5p Inhibitor中细胞增殖抑制率[(15.22±1.32)%比(56.37±2.32)%]、凋亡率[(11.96±0.80)%比(23.81±1.35)%]降低,划痕愈合率[(48.92±3.15)%比(23.83±1.55)%]、克隆形成数[(108.56±3.86)比(54.44±2.50)个]和侵袭细胞数[(77.08±7.95)比(29.65±3.42)个]及裸鼠移植瘤体积与质量升高(P均<0.05)。结论沉默circXPO1可通过上调miR-195-5p抑制肝癌细胞增殖、迁移和侵袭,促进凋亡。 展开更多
关键词 环状RNA miR-195-5p 肝癌 增殖 迁移 侵袭 凋亡
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