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Ultrahigh-Mass-Loading Electrodes With Enhanced Homogeneity Using a High-Concentration Slurry for Lithium-Ion Batteries 认领 引用
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作者 Jun Kyu Park Woohyeon Shin +14 位作者 Woohyeon Jo Hyo-Jeong Lee Won-Yong Jeon Jinho Ahn Jihee Yoon Yea-Ji Jeong Joonyoung Oh Minji Kang Min-Jae Choi Jin Joo Jongsoon Kim Seong-Keun Cho Jun Dong Park Jaewook Nam Jung-Keun Yoo 《Carbon Energy》 SCIE EI CAS CSCD 2026年第1期126-137,共12页
Strategies for achieving high-energy-density lithium-ion batteries include using high-capacity materials such as high-nickel NCM,increasing the active material content in the electrode by utilizing high-conductivity c... Strategies for achieving high-energy-density lithium-ion batteries include using high-capacity materials such as high-nickel NCM,increasing the active material content in the electrode by utilizing high-conductivity carbon nanotubes(CNT)conductive materials,and electrode thickening.However,these methods are still limited due to the limitation in the capacity of high-nickel NCM,aggregation of CNT conductive materials,and nonuniform material distribution of thick-film electrodes,which ultimately damage the mechanical and electrical integrity of the electrode,leading to a decrease in electrochemical performance.Here,we present an integrated binder-CNT composite dispersion solution to realize a high-solids-content(>77 wt%)slurry for high-mass-loading electrodes and to mitigate the migration of binder and conductive additives.Indeed,the approach reduces solvent usage by approximately 30%and ensures uniform conductive additive-binder domain distribution during electrode manufacturing,resulting in improved coating quality and adhesive strength for high-mass-loading electrodes(>12 mAh cm−2).In terms of various electrode properties,the presented electrode showed low resistance and excellent electrochemical properties despite the low CNT contents of 0.6 wt%compared to the pristine-applied electrode with 0.85 wt%CNT contents.Moreover,our strategy enables faster drying,which increases the coating speed,thereby offering potential energy savings and supporting carbon neutrality in wet-based electrode manufacturing processes. 展开更多
关键词 cathodes dispersibility dispersion solution high-mass-loading lithium-ion batteries
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Scavenger receptor-mediated lung-targeted delivery of anti-miR-155 oligoDNA nanomicelles with curcumin for acute lung injury therapy 认领 引用
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作者 Minji Kang Jihun Oh +1 位作者 Eunjy Kim Minhyung Lee 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2026年第3期185-201,共17页
Antisense oligonucleotides offer a powerful strategy for suppressing pro-inflammatory microRNAs,but efficient long-term delivery after systemic administration remains challenging.In this study,we developed a self-asse... Antisense oligonucleotides offer a powerful strategy for suppressing pro-inflammatory microRNAs,but efficient long-term delivery after systemic administration remains challenging.In this study,we developed a self-assembling oligoDNA-nanomicelle(ODmicelle)platform to simultaneously deliver antisense oligoDNA targeting miR-155 and curcumin,a hydrophobic anti-inflammatory agent,to the lung.The curcumin formulation(OD-micelle/Cur)can be administered intravenously and has a negatively charged surface and average particle size of∼160 nm,supporting scavenger receptor(SR)-mediated pulmonary delivery.Fluorescence imaging and flow cytometry analyses demonstrated that cellular uptake was comparable to that of OD-micelle/PEI25k,a widely used cationic carrier standard.Hemocompatibility tests demonstrated reduced red blood cell aggregation,compared with PEI25k,indicating improved hemocompatibility without compromising delivery efficiency.Mechanistic studies supported the receptor-dependent transport of the oligoDNA corona.Pre-treatment with excess oligonucleotides reduced the cellular uptake and in vivo lung accumulation of Cy5-labeled OD-micelle/Cur.Furthermore,a RAGE antagonist peptide similarly reduced cellular uptake,suggesting the involvement of RAGE in the SR pathway.In LPS-induced acute lung injury(ALI)mice and LPSstimulated Raw264.7 cells,the OD-micelle/Cur suppressed the inflammatory response,decreased TNF-αand IL-6 levels,and improved lung histopathology.The antisense oligoDNA corona contributed to the efficacy through miR-155 inhibition,which was confirmed by comparison with scrambled OD-micelle/Cur and increased SOCS1 expression in lung tissue.Furthermore,RAGE pathway inhibition attenuated the inflammatory response,suggesting that RAGE signaling could be an additional therapeuticmechanism.Therefore,OD-micelles are a systemically administrable,lung-targeted oligonucleotide nanoplatform with dualmechanism anti-inflammatory activity for the treatment of ALI. 展开更多
关键词 Acute lung injury OligoDNA Curcumin RAGEs MicroRNA-155
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Serum Extracellular Vesicle-Associated GULP1 Is a Key Indicator of Hepatocellular Carcinoma 认领 引用
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作者 Hyung Seok Kim Ju A Son +8 位作者 Minji Kang Soon Sun Kim Geum Ok Baek Moon Gyeong Yoon Se Ha Jang Dokyung Jung Ji Eun Han Jae Youn Cheong Jung Woo Eun 《Oncology Research》 SCIE 2026年第2期327-345,共19页
Objectives:Early detection of hepatocellular carcinoma(HCC)is a significant challenge due to the limited sensitivity of alpha-fetoprotein(AFP).This study aimed to assess serum-derived extracellular vesicleencapsulated... Objectives:Early detection of hepatocellular carcinoma(HCC)is a significant challenge due to the limited sensitivity of alpha-fetoprotein(AFP).This study aimed to assess serum-derived extracellular vesicleencapsulated GULP PTB domain-containing engulfment adaptor 1(EV-GULP1)as a novel,noninvasive biomarker for HCC detection and prognosis,leveraging the potential of tumor-specific molecules carried by small extracellular vesicles(EVs).Methods:The study utilized both internal and external cohorts of HCC patients and controls.Small EVs were isolated from serum samples,then characterized and validated to confirm their identity.The expression levels of EV-GULP1 were quantified using quantitative reverse transcription polymerase chain reaction(qRT-PCR).Results:EVGULP1 expression was found to be significantly higher in HCC patients,including those with early-stage disease,when compared to control groups.It demonstrated superior diagnostic accuracy over AFP,achieving an area under the curve(AUC)of 0.919,and was particularly effective in detecting AFP-negative cases.Furthermore,high EV-GULP1 expression correlated with worse overall and disease-free survival outcomes.Conclusion:These findings highlight EV-GULP1 as a highly promising noninvasive biomarker for hepatocellular carcinoma.It offers improved diagnostic accuracy for early detection and better risk stratification for prognosis compared to the current standard,AFP. 展开更多
关键词 Extracellular vesicles GULP PTB domain-containing engulfment adaptor 1 hepatocellular carcinoma liquid biopsy biomarker
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Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma 认领 引用 被引量：1
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作者 Youngki Lee Subin Kang +7 位作者 Le Thi Thuy Mincheol Son Jae Young Park Sung Bin Ahn Minji Kang Jihun Oh Joon Sig Choi Minhyung Lee 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2025年第1期132-143,共12页
Herpes simplex virus thymidine kinase(HSVtk)gene therapy is a promising strategy for glioblastoma therapy.However,delivery of plasmid DNA(pDNA)encoding HSVtk into the brain by systemic administration is a challenge si... Herpes simplex virus thymidine kinase(HSVtk)gene therapy is a promising strategy for glioblastoma therapy.However,delivery of plasmid DNA(pDNA)encoding HSVtk into the brain by systemic administration is a challenge since pDNA can hardly penetrate the bloodbrain barrier.In this study,an exosome-membrane(EM)and polymer-based hybrid complex was developed for systemic delivery of pDNA into the brain.Histidine/arginine-linked polyamidoamine(PHR)was used as a carrier.PHR binds to pDNA by electrostatic interaction.The pDNA/PHR complex was mixed with EM and subjected to extrusion to produce pDNA/PHR-EM hybrid complex.For glioblastoma targeting,T7 peptide was attached to the pDNA/PHR-EM complex.Both pDNA/PHR-EM and T7-decorated pDNA/PHR-EM(pDNA/PHREM-T7)had a surface charge of–5 mV and a size of 280 nm.Transfection assays indicated that pDNA/PHR-EM-T7 enhanced the transfection to C6 cells compared with pDNA/PHREM.Intravenous administration of pHSVtk/PHR-EM-T7 showed that pHSVtk/PHR-EM and pHSVtk/PHR-EM-T7 delivered pHSVtk more efficiently than pHSVtk/lipofectamine and pHSVtk/PHR into glioblastoma in vivo.pHSVtk/PHR-EM-T7 had higher delivery efficiency than pHSVtk/PHR-EM.As a result,the HSVtk expression and apoptosis levels in the tumors of the pHSVtk/PHR-EM-T7 group were higher than those of the other control groups.Therefore,the pDNA/PHR-EM-T7 hybrid complex is a useful carrier for systemic delivery of pHSVtk to glioblastoma. 展开更多
关键词 Exosome Glioblastoma Plasmid DNA Polymeric carrier Targeted delivery
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A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO2 reduction reaction 认领 引用
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作者 Gyeong Ho Han Jung Yong Seo +4 位作者 Minji Kang Myung-gi Seo Youngheon Choi Soo Young Kim Sang Hyun Ahn 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期8-15,I0001,共8页
Cu catalysts can convert CO2 through an electrochemical reduction reaction into a variety of useful carbon-based products.However,this capability provides an obstacle to increasing the selectivity for a single prod... Cu catalysts can convert CO2 through an electrochemical reduction reaction into a variety of useful carbon-based products.However,this capability provides an obstacle to increasing the selectivity for a single product.Herein,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO2 electrolyzer for the electrochemical CO2 reduction reaction(ECRR)with high selectivity for CO production.When the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is suppressed.Introducing a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO2 electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 Vcell.We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd alloy.The phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C2H_4 at high voltage.The results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored. 展开更多
关键词 Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer
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Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease 认领 引用
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作者 Jun Sung Park Go Hun Seo +10 位作者 Yunha Choi Soojin Hwang Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong Sop Lee Jae Suk Baek Beom Hee Lee 《Congenital Heart Disease》 SCIE 2022年第6期653-673,共21页
Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvest... Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvestigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHDand the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromicCHD aged 0.05), betweenthe groups with and without a diagnostic variant. However, patients with ≥3 extracardiac phenotypes had a significantlyhigher likelihood of having a diagnostic variant than those with ≤2 (38.3% vs. 5.9%, odds ratio = 9.93,95% confidence interval = 1.21–81.44, P = 0.013). Conclusions: The number of extracardiac phenotypes is importantin predicting the possibility of genetic diagnosis. Physicians will be able to select patients with a high probabilityof genetic diagnosis and provide appropriate genetic counseling based on the results of this study. 展开更多
关键词 Heart defects congenital whole-exome sequencing genetic testing phenotype
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High Prevalence of Genetic Alterations in Infantile-Onset Cardiomyopathy 认领 引用
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作者 Junsung Park Go Hun Seo +10 位作者 Yena Lee Yunha Choi Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong Sop Lee Jae Suk Baek Beom Hee Lee 《Congenital Heart Disease》 SCIE 2021年第4期397-410,共14页
Background and Method:The genetic cause of infantile-onset cardiomyopathy is rarely investigated.Here,we conducted whole exome sequencing(WES)and mitochondrial DNA(mtDNA)sequencing in eight patients with infantile-ons... Background and Method:The genetic cause of infantile-onset cardiomyopathy is rarely investigated.Here,we conducted whole exome sequencing(WES)and mitochondrial DNA(mtDNA)sequencing in eight patients with infantile-onset cardiomyopathy to identify genetic variations.Result:Among these patients,two(25%)had dilated cardiomyopathy(DCMP),two(25%)had left ventricular non-compaction(LVNC),and four(50%)had hypertrophic cardiomyopathy(HCMP).Except four patients identified prenatally,the remaining patients presented at a median age of 85.5 days.WES identified genetic variants in a total of seven(87.5%)patients and mtDNA sequencing in the other case.TPM1 and MYH7 variants were identified in the two patients with DCMP;MYH11 and MYLK2 variants in the two patients with LVNC;HRAS,BRAF,and MYH7 variants in three patients with HCMP;and MT-ND1 variant in one patient with HCMP having high blood lactic acid levels.Among the eight variants,four were classified as pathogenic or likely-pathogenic according to the American College of Medical Genetics(ACMG)guidelines,and the remaining were identified as variants of unknown significance(VUSs).Three pathogenic mutations were de novo,whereas four(likely-pathogenic or VUSs)were inherited from a respective parent,excluding one variant where parental testing was unavailable,questioning whether these inherited variants are disease-causing.Three patients died before 3 months of age.Conclusion:Genomic studies,such as WES with additional mtDNA sequencing,can identify a genetic variant in high proportions of patients with infantile-onset cardiomyopathy.The clinical implication of the parentally inherited variant needs to be assessed in a larger patient and family cohort with a longitudinal follow-up. 展开更多
关键词 Cardiomyopathy whole exome sequencing infantile-onset
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Preparation and characterization of poly(propylene glycol)-conjugated cationic polymers for efficient gene delivery 认领 引用
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作者 Gyeonghui Yu Minji Kang Hyejung Mok 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2016年第1期170-171,共2页
Nucleic acid drugs are desirable therapeutics for the treatment of fatal diseases like cancers.For clinical translation of nucleic acid drugs,carrier systems that protect nucleic acid from degradation and help cellula... Nucleic acid drugs are desirable therapeutics for the treatment of fatal diseases like cancers.For clinical translation of nucleic acid drugs,carrier systems that protect nucleic acid from degradation and help cellular uptake are needed.Accordingly cationic polymers are used as a carrier due to their strong electrostatic interaction with nucleic acids,which produce nanosized particles[1]. 展开更多
关键词 Branched polyethylenimine Micelle Thermosensitive ε-Poly-L-Lysine(ε-PLL)
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Fiber-reinforced origami electronics with high rigidity and flexibility for display applications 认领 引用
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作者 Dohyeon Gong Minji Kang +4 位作者 Suhyeon Hwang Junggwang Jo Insic Hong Yeonwook Roh Seungyong Han 《npj Flexible Electronics》 SCIE CSCD 2025年第1期614-623,共10页
Origami structures provide functional advantages to rigid electronics through geometric transformations.However,the transformations involved in folding and deployment cause stress concentration on flexure hinges of or... Origami structures provide functional advantages to rigid electronics through geometric transformations.However,the transformations involved in folding and deployment cause stress concentration on flexure hinges of origami structure,triggering electronic malfunction.Here,we report origami electronics based on a fiber-reinforced electronic composite.A thin PEDOT:PSS-based electronic composite minimizes stress during folding without electrode damage.Nylon is embedded in this foldable composite and,despite being thin and flexible for folding,provides high tensile resistance to prevent plastic deformation and tearing under tension.This strategy enables the creation of flexure hinges for origami electronics that maintain mechanical and electrical stability under repeated transformations.Origami electronics that integrate the high-durability composite can be used in display applications supporting 25-fold compression with the Flasher origami structure and 2D-to-3D deployment with the Kresling origami structure.The ability of origami electronics to withstand bending and tensile stress enables shape-reconfigurable displays requiring repeated reconfiguration across multiple hinges. 展开更多
关键词 origami structuretriggering flexure hinges rigid electronics origami structures electronic malfunctionherewe fiber reinforced electronics high rigidity origami electronics
Pulmonary delivery of cell membrane-derived nanovesicles carrying anti-miRNA155 oligonucleotides ameliorates LPS-induced acute lung injury 认领 引用 被引量：2
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作者 Chuanyu Zhuang Minji Kang +1 位作者 Jihun Oh Minhyung Lee 《Regenerative Biomaterials》 SCIE EI CSCD 2025年第2期99-109,共11页
Acute lung injury(ALI)is a devastating inflammatory disease.MicroRNA155(miR155)in alveolar macrophages and lung epithelial cells enhances inflammatory reactions by inhibiting the suppressor of cytokine signaling 1(SOC... Acute lung injury(ALI)is a devastating inflammatory disease.MicroRNA155(miR155)in alveolar macrophages and lung epithelial cells enhances inflammatory reactions by inhibiting the suppressor of cytokine signaling 1(SOCS1)in ALI.Anti-miR155 oligonucleotide(AMO155)have been suggested as a potential therapeutic reagent for ALI.However,a safe and efficient carrier is required for delivery of AMO155 into the lungs for ALI therapy.In this study,cell membrane-derived nanovesicles(CMNVs)were produced from cell membranes of LA4 mouse lung epithelial cells and evaluated as a carrier of AMO155 into the lungs.For preparation of CMNVs,cell membranes were isolated from LA4 cells and CMNVs were produced by extrusion.Cholesterol-conjugated AMO155(AMO155c)was loaded into CMNVs and extracellular vesicles(EVs)by sonication.The physical characterization indicated that CMNVs with AMO155c(AMO155c/CMNV)were membrane-structured vesicles with a size of�120nm.The delivery efficiency and therapeutic efficacy of CMNVs were compared with those of EVs or polyethylenimine(25kDa,PEI25k).The delivery efficiency of AMO155c by CMNVs was similar to that by EVs.As a result,the miR155 levels were reduced by AMO155c/CMNV and AMO155c/EV.AMO155c/CMNV were administered intratracheally into the ALI models.The SOCS1 levels were increased more efficiently by AMO155c/CMNV than by the others,suggesting that miR155 effectively was inhibited by AMO155c/CMNV.In addition,the inflammatory cytokines were reduced more effectively by AMO155c/CMNV than they were by AMO155c/EV and AMO155c/PEI25k,reducing inflammation reactions.The results suggest that CMNVs are a useful carrier of AMO155c in the treatment of ALI. 展开更多
关键词 acute lung injury exosome-mimetic nanovesicle extracellular vesicles microRNA155 suppressor of cytokine signaling 1
Transient shuttle for a widespread neural probe with minimal perturbation 认领 引用 被引量：2
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作者 Yeonwook Roh Hyeongseok Kim +13 位作者 Eun-A Kim Kyungbin Ji Minji Kang Dohyeon Gong Sunghoon Im Insic Hong Jieun Park Soo Jung Park YiseulBae Jae-Il Park Je-Sung Koh Seungyong Han Eun Jeong Lee Daeshik Kang 《npj Flexible Electronics》 SCIE 2024年第1期498-508,共11页
Bioelectronic implants in the deep brain provide the opportunity to monitor deep brain activity with potential applications in disease diagnostics and treatment.However,mechanical mismatch between a probe and brain ti... Bioelectronic implants in the deep brain provide the opportunity to monitor deep brain activity with potential applications in disease diagnostics and treatment.However,mechanical mismatch between a probe and brain tissue can cause surgical trauma in the brain and limit chronic probe-based monitoring,leading to performance degradation.Here,we report a transient shuttle-based probe consisting of a PVA and a mesh-type probe.A rigid shuttle based on PVA implants an ultrathin mesh probe in the target deep brain without a tangle,while creating both a sharp edge for facile penetration into the brain and an anti-friction layer between the probe and brain tissue through dissolving its surface.The capability to shuttle dissolved materials can exclude the retracted process of the shuttle in the brain.Complete dissolution of the shuttle provides a dramatic decrease(~1078-fold)in the stiffness of the probe,which can therefore chronically monitor a wide area of the brain.These results indicate the ability to use a simplistic design for implantation of wide and deep brain probes while preventing unnecessary damage to the brain and probe degradation during long-term use. 展开更多
关键词 shuttle neural implantation
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