Organic and inorganic pore networks in medium-to low-maturity shale:Insights from SEM analysis of Shahejie Formation in the Dongying Sag 认领 引用

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作者 Zi-Zhi Lin Qin-Hong Hu +4 位作者 Na Yin Yu-Shan Du Jing Chao Guang-Lei Zhang Song-Tao Wu 《Petroleum Science》 SCIE EI CAS CSCD 2026年第1期69-83,共15页

The spatial distribution and structural characteristics of organic and inorganic pore networks are crucial for evaluating the storage capacity of medium-to low-maturity shale reservoirs.Based on scanning electron micr... The spatial distribution and structural characteristics of organic and inorganic pore networks are crucial for evaluating the storage capacity of medium-to low-maturity shale reservoirs.Based on scanning electron microscopy images of Shahejie Formation shales in the Dongying Sag,this study established an efficient,low cost,and reliable technical method for quantitatively analyzing the structural characteristics and geological control factors of organic and inorganic pores.Shales exhibit three main pore systems:(1)nanoscale intragranular pores in clay minerals,calcite,and pyrite;(2)nano-to micronscale pores between mineral particles and organic-inorganic interface pores;and(3)micron-to millimeter-scale microfractures at the laminar interface.The number and surface porosity of organic and inorganic pores are highly correlated with the content of shale components.Organic pores in shales mostly exist in the form of organic-inorganic interface pores,with an average pore size of 600-800 nm,providing the surface porosity of 14.9%,which has an important influence on the development of submicron(200-1000 nm)scale pores.The number of inorganic pores contributes 91.45%of the total number of pores and accounts for 85.1%of the total surface porosity.The influence of clay mineralrelated pores is the most significant in inorganic pores;it not only has a significant impact on the pores in the pore size range of 0-200 nm but also affects the development of micron-scale pores together with calcite.The fractal results show that the morphological complexity of inorganic pores is higher than that of organic pores.In addition,low-resolution images will greatly underestimate the contribution of nanoscale pores to the reservoir space.Therefore,the quantitative evaluation of dense porous media should comprehensively consider the weight of resolution and field of view.The results of this study provide important microstructural data for an in-depth understanding of the organic and inorganic pore structure characteristics of medium-and low-maturity shales,and for providing more accurate reservoir quality evaluation for shale resource exploration. 展开更多

关键词 Dongying Sag Shahejie Formation Low-mature shale Field emission scanning electron Microscopy Organic-inorganic pores Two-dimensional porosity Multiscale SEM imaging

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Boosting Chemodynamic Therapy by the Synergistic Effect of Co‑Catalyze and Photothermal Effect Triggered by the Second Near‑Infrared Light 认领 引用 被引量：10

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作者 Songtao Zhang Longhai Jin +10 位作者 Jianhua Liu Yang Liu Tianqi Zhang Ying Zhao Na Yin Rui Niu Xiaoqing Li Dongzhi Xue Shuyan Song Yinghui Wang Hongjie Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第12期318-330,共13页

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the... In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction(i.e.,chemodynamic therapy,CDT)has been attracted more attentions in recent years,the limited Fenton reaction efficiency is the important obstacle to further application in clinic.Herein,we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin(FeO/MoS2-BSA)with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared(NIR II)light.In the tumor microenvironments,the MoS2 nanosheets not only can accelerate the conversion of Fe3+ions to Fe2+ions by Mo4+ions on their surface to improve Fenton reaction efficiency,but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy(PTT).Consequently,benefiting from the synergetic-enhanced CDT/PTT,the tumors are eradicated completely in vivo.This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT. 展开更多

关键词 Chemodynamic therapy Fenton reaction Co-catalysis Photothermal effect NIR II biowindows

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Neonatal rhesus monkeys as an animal model for rotavirus infection 认领 引用 被引量：2

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作者 Na Yin Feng-Mei Yang +8 位作者 Hong-Tu Qiao Yan Zhou Su-Qin Duan Xiao-Chen Lin Jin-Yuan Wu Yu-Ping Xie Zhan-Long He Mao-Sheng Sun Hong-Jun Li 《World Journal of Gastroenterology》 SCIE CAS 2018年第45期5109-5119,共11页

AIM To establish a rotavirus(RV)-induced diarrhea model using RV SA11 in neonatal rhesus monkeys for the study of the pathogenic and immune mechanisms of RV infection and evaluation of candidate vaccines.METHODS Neona... AIM To establish a rotavirus(RV)-induced diarrhea model using RV SA11 in neonatal rhesus monkeys for the study of the pathogenic and immune mechanisms of RV infection and evaluation of candidate vaccines.METHODS Neonatal rhesus monkeys with an average age of 15-20 d and an average weight of 500 g ± 150 g received intragastric administration of varying doses of SA11 RV( 107 PFUs/mL, 106 PFUs/mL, or 105 PFUs/mL, 10 mL/animal) to determine whether the SA11 strain can effectively infect these animals by observing their clinical symptoms, fecal shedding of virus antigen by ELISA, distribution of RV antigen in the organs by immunofluorescence, variations of viral RNA load in the organs by qRT-PCR, histopathological changes in the small intestine by HE staining, and apoptosis of small intestinal epithelial cells by TUNEL assay.RESULTS The RV monkey model showed typical clinical diarrhea symptoms in the 108 PFUs SA11 group, where we observed diarrhea 1-4 d post infection(dpi) and viral antigen shed in the feces from 1-7 dpi. RV was found in jejunal epithelial cells. We observed a viral load of approximately 5.85 × 103 copies per 100 mg in the jejunum at 2 dpi, which was increased to 1.09 × 105 copies per 100 mg at 3 dpi. A relatively high viral load was also seen in mesenteric lymph nodes at 2 dpi and 3 dpi. The following histopathological changes were observed in the small intestine following intragastric administration of SA11 RV: vacuolization, edema, and atrophy. Apoptosis in the jejunal villus epithelium was also detectable at 3 dpi.CONCLUSION Our results indicate that we have successfully established a RV SA11 strain diarrhea model in neonatal rhesus monkeys. Future studies will elucidate the mechanisms underlying the pathogenesis of RV infection, and we will use the model to evaluate the protective effect of candidate vaccines. 展开更多

关键词 Rotavirus Neonatal rhesus monkey Animal model Infection Diarrhea

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Isolation and characterization of a new candidate human inactivated rotavirus vaccine strain from hospitalized children in Yunnan,China:2010-2013 认领 引用 被引量：1

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作者 Jin-Yuan Wu Yan Zhou +7 位作者 Guang-Ming Zhang Guo-Fa Mu Shan Yi Na Yin Yu-Ping Xie Xiao-Chen Lin Hong-Jun Li Mao-Sheng Sun 《World Journal of Clinical Cases》 SCIE 2018年第11期426-440,共15页

AIM To determine the distribution of rotavirus VP7 gene in hospitalized children in Yunnan, China. METHODS A total of 366 stool specimens were collected from hospitalized children in hospitals in Yunnan Province from ... AIM To determine the distribution of rotavirus VP7 gene in hospitalized children in Yunnan, China. METHODS A total of 366 stool specimens were collected from hospitalized children in hospitals in Yunnan Province from September 2010 to December 2013. The genomic RNA electropherotypes and the G genotypes of the rotaviruses were determined. A phylogenetic analysis of the VP7 gene was performed. Rotavirus isolation was performed, and characterized by plaque, minimum essential medium, and all genes sequence analysis. Quantification of antibodies for inactivated vaccine prepared with ZTR-68 was examined by enzyme-linked immunosorbent assay and microneutralization assay.RESULTS Group A human rotavirus was detected in 177 of 366(48.4%) stool samples using a colloidal gold device assay. The temporal distribution of rotavirus cases showed significant correlation with the mean air temperature. Rotaviruses were isolated from 13% of the rotavirus-positive samples. The predominant genotype was G1(43.5%), followed by G3(21.7%), G9(17.4%), G2(4.3%), G4(8.7%), and mixed(4.3%) among a total of 23 rotavirus isolates. A rotavirus strain was isolated from a rotavirus-positive stool sample of a 4-month-old child in The First People's Hospital of Zhaotong(2010) for use as a candidate human inactivated rotavirus vaccine strain and for further research, and was designated ZTR-68. The genotype of 11 gene segments of strain ZTR-68(RVA/Human-wt/CHN/ZTR-68/2010/G1P[8]) was characterized. The genotype constellation of strain ZTR-68 was identified as G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. The VP7 and VP4 genotypes of strain ZTR-68 were similar to Wa-like strains.CONCLUSIONS A high prevalence of the G1, G2, and G3 genotypes was detected from 2010 to 2012. However, a dominant prevalence of the G9 genotype was identified as the cause of gastroenteritis in children in Yunnan, China, in 2013. A candidate human inactivated rotavirus vaccine strain, designated ZTR-68 was isolated, characterized, and showed immunogenicity. Our data will be useful for the future formulation and development of a vaccine in China. 展开更多

关键词 Rotavirus Genotype G G1P[8] Inactivated rotavirus vaccine Genotype characterization Rapid antigen detection kit Phylogenetic analysis

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Endocytosis of FcαR is clathrin and dynamin dependent,but its cytoplasmic domain is not required 认领 引用 被引量：1

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作者 Min Peng Na Yin Wei Zhang 《Cell Research》 SCIE CAS 2010年第2期223-237,共15页

FcαR,the Fc receptor for IgA,is essential for IgA-mediated immune responses.Previous studies have shown that IgA and IgA immune complexes can be rapidly endocytosed by FcαR.However,the underlying mechanism remains u... FcαR,the Fc receptor for IgA,is essential for IgA-mediated immune responses.Previous studies have shown that IgA and IgA immune complexes can be rapidly endocytosed by FcαR.However,the underlying mechanism remains unclear.Here,we investigated the endocytic pathway of FcαR in monocytic cell line,U937,that naturally express FcuR and in transfected Chinese hamster ovary(CHO),COS-7 and Hela cells.By using selective chemical inhibitors of different endocytic pathways,overexpression of dominant-negative mutants of Eps15 and knockdown of clathrin heavy chain(CHC)via RNA interference,we demonstrated that endocytosis of FcaR was through a clathrin-mediated pathway.The endocytosed FcαR went into Rab5-and Rabll-positive endosomes.However,endocytosis of FcaR could not be blocked by a dominant-negative mutant of Rab5.We also demonstrated that endocytosis of FcαR was dynamin-dependent by overexpressing a dominant-negative mutant of dynamin.The potential endocytic motif for FcαR was also examined.Unexpectedly,we found that the entire cytoplasmic domain of FcaR was not required for the endocytic process of FcαR.We conclude that endocytosis of FcaR is clathrin-and dynamin-dependent,but is not regulated by RabS,and the endocytic motif is not located in the cytoplasmic domain of FcαR. 展开更多

关键词 IgA Fc receptor endocytosis clathrin dynamin

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Research and Practice of Cardiopulmonary Rehabilitation Training Programs 认领 引用

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作者 Na Yan Maiding He +9 位作者 Jinyue Jiang Juan Luo Ping Zhan Xichan Wang Xia Gao Jianzhu Wang Na Yin Fang Ye Jinghua Yu Shiying Zhang 《World Journal of Cardiovascular Diseases》 CAS 2024年第9期557-566,共10页

In today’s society, the incidence of cardiopulmonary diseases is increasing annually, seriously affecting patients’ quality of life. Therefore, developing a scientific and effective rehabilitation training program i... In today’s society, the incidence of cardiopulmonary diseases is increasing annually, seriously affecting patients’ quality of life. Therefore, developing a scientific and effective rehabilitation training program is of great significance. This study first analyzes the theoretical basis of cardiopulmonary rehabilitation training, including the effects of aerobic exercise, interval training, and strength training on cardiopulmonary function. Based on this, a comprehensive rehabilitation training program is designed, which includes personalized training plans, comprehensive interventions, multidisciplinary collaboration, patient education, and regular follow-up visits. The cardiopulmonary rehabilitation training plan developed in this study has certain scientific practicability, which provides a theoretical basis for cardiopulmonary rehabilitation training, and also provides a reference for medical institutions, rehabilitation centers and communities, which is helpful for promotion and application to a wider range of patients with cardiopulmonary diseases. 展开更多

关键词 Cardiopulmonary Function Rehabilitation Training Program Aerobic Exercise Interval Training

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The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel 认领 引用 被引量：8

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作者 Zi-Zhi Lin Jun-Qian Li +8 位作者 Shuang-Fang Lu Qin-Hong Hu Peng-Fei Zhang Jun-Jie Wang Qi Zhi Hong-Sheng Huang Na Yin Yue Wang Tian-Chen Ge 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期1-13,共13页

The occurrence characteristics of shale oil are of great significance to the movability of shale oil.In this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin wer... The occurrence characteristics of shale oil are of great significance to the movability of shale oil.In this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization experiments.The Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,respectively.among which the silicon-rich shale has the best oil-bearing.The relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 nm.When the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 nm.The occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space. 展开更多

关键词 Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

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Biodegradable hollow MOFs-based nano-modulator for collaboratively blocking energy metabolism for immunotherapy of orthotopic gliomas 认领 引用 被引量：1

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作者 Shiqi Bai Hongya Zhang +13 位作者 Rong Mou Shaopeng Zhang Na Yin Yue Cao Wanying Li Ziqian Wang Bin Wang Donghao Qu Shuyan Song Yunqian Li Xinrui Liu Yanfang Jiang Yinghui Wang Hongjie Zhang 《Science China Materials》 SCIE EI CAS CSCD 2025年第10期3819-3830,共12页

The immunosuppressive tumor microenvironment(TME)of gliomas makes their treatment consistently suboptimal,and the aberrant energy metabolism of glioma cells orchestrates tumorigenesis and the immunosuppressive TME.In ... The immunosuppressive tumor microenvironment(TME)of gliomas makes their treatment consistently suboptimal,and the aberrant energy metabolism of glioma cells orchestrates tumorigenesis and the immunosuppressive TME.In this work,we construct a biodegradable nano-modulator(ZIF-90@MnO₂@GPNA,ZMG)based on ZIF-90 decorated by MnO₂and loaded with glutamine transport antagonist(L-γ-glutamyl-p-nitroanilide,GPNA)for efficiently gliomas therapy by multi-pathways inhibition of energy metabolism and reshaping TME.In order to efficiently cross the blood-brain barrier(BBB)and target the gliomas,hyaluronic acid(HA)and lactoferrin(Lf)are further functionalized on its surface(ZIF-90@MnO₂@GPNA@HA-Lf,ZMGH-Lf).ZMGHLf biodegrades in response to stimulation of TME,releasing Mn²⁺,which can catalyze H₂O₂to·OH and lead to mitochondrial dysfunction.ZMGH-Lf can inhibit glycolysis by alleviating hypoxia and reducing NAD⁺expression,while loaded GPNA inhibits the compensatory increase in glutamine uptake.This therapeutic strategy not only achieves a multipathway disruption of glioma metabolism,but also relieves the immune resistance and improves the immune TME.All these findings demonstrate that ZMGH-Lf can effectively inhibit gliomas by multi-ways manipulation of energy metabolism and immunotherapy,which provides a new strategy for the treatment of gliomas. 展开更多

关键词 glioma energy metabolism tumor microenvironment immunotherapy

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Synthesis,Electrical Conductivity and Seebeck Coefficient of La_0.9A_0.1FeO₃(A=Mg,Ca,Sr,Ba) 认领 引用

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作者 Na Yin Hongchao Wang Chunlei Wang 《Journal of Materials Science & Technology》 SCIE EI CAS 2010年第12期1103-1106,共4页

Lanthanum ferrites ceramics La0.9A0.1FeO3(A=Mg,Ca,Sr,Ba)have been prepared by solid state reaction.X-ray power diffraction analysis reveals that all samples are of pure perovskite structure with orthorhombic phase.Ele... Lanthanum ferrites ceramics La0.9A0.1FeO3(A=Mg,Ca,Sr,Ba)have been prepared by solid state reaction.X-ray power diffraction analysis reveals that all samples are of pure perovskite structure with orthorhombic phase.Electrical conductivity and Seebeck coefficient have been measured in vacuum within the temperature range between room temperature and 800℃.The electrical conductivity shows semiconducting behavior.Temperature dependence of electrical conductivity indicates that adiabatic small-polaron hopping mechanism is dominant for their electric transportations.Seebeck coefficients are positive for samples,suggesting ptype conduction in the whole temperature range.The highest Seebeck coefficient is found to be 654μV/K for La0.9A0.1FeO3.Except La0.9A0.1FeO3,the electrical conductivity of La0.9A0.1FeO3 increases with increasing atomic number of the A-site element,while Seebeck coefficient decreases. 展开更多

关键词 La0.9A0.1FeO3 ceramics Electrical conductivity Seebeck coefficient

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Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure 认领 引用 被引量：3

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作者 Na Yin Wenjun Zhang +4 位作者 Runxiu Wei Qiang Yang Fengming He Ling Guo Min Feng 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2022年第6期867-879,共13页

Acute liver failure(ALF)is a mortal and critical hepatic disease,in which oxidative stress,inflammation storm and hepatocyte death are crucial in the pathogenesis.Hence,in contrast to the control of a single link,a co... Acute liver failure(ALF)is a mortal and critical hepatic disease,in which oxidative stress,inflammation storm and hepatocyte death are crucial in the pathogenesis.Hence,in contrast to the control of a single link,a combination therapy targeting multiple pathogenic links of the disease will be a favorable means to control the progression of the disease.In this study,we constructed dimethyl itaconate-loaded liposomes modified with dodecyl gallate as a cocktail activator to investigate its functional role in acetaminophen(APAP)-induced ALF.Our results demonstrated that the cocktail activator acted on hepatocytes and triggered cocktail efficacy,thereby simultaneously attenuating APAP-induced hepatocyte damage and remodeling the damage microenvironment.The cocktail activator could effectively scavenge reactive oxygen species,inhibit excessive inflammatory responses and reduce cell death in impaired hepatocytes for detoxification.More importantly,the cocktail activator could remodel the damage microenvironment,thus further promoting hepatocyte expansion and specifically switching macrophages from the M1 to M2 phenotype for a favorable liver regeneration of ALF.Furthermore,in APAP-induced ALF mouse model,the cocktail activator improved liver function,alleviated histopathological damage and increased survival rate.In summary,these findings indicate that the cocktail activator may provide a promising therapeutic approach for ALF treatment as a nanomedicine. 展开更多

关键词 Cocktail activator Dimethyl itaconate Dodecyl gallate Hepatocyte Microenvironment modulation

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Intervention Effect of Lower Limb Rehabilitation Robot with Task-Oriented Training on Stroke Patients and Its Influence on KFAROM Score 认领 引用 被引量：2

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作者 Maiding He Li Huang +9 位作者 Dekun Tang Mei Qin Ping Zhan Xichan Wang Xia Gao Jianzhu Wang Na Yin Hui Xu Yonghua Yang Kaihua Tang 《Journal of Biosciences and Medicines》 2024年第9期62-72,共11页

Objective: To explore the effect of lower limb rehabilitation robot combined with task-oriented training on stroke patients and its influence on KFAROM score. Methods: 100 stroke patients with hemiplegia admitted to o... Objective: To explore the effect of lower limb rehabilitation robot combined with task-oriented training on stroke patients and its influence on KFAROM score. Methods: 100 stroke patients with hemiplegia admitted to our hospital from January 2023 to December 2023 were randomly divided into two groups, the control group (50 cases) was given task-oriented training assisted by nurses, and the observation group (50 cases) was given lower limb rehabilitation robot with task-oriented training. Lower limb balance, lower limb muscle strength, motor function, ankle function, knee flexion range of motion and walking ability were observed. Results: After treatment, the scores of BBS, quadriceps femoris and hamstrings in the observation group were significantly higher than those in the control group (P Conclusion: In the clinical treatment of stroke patients, the combination of task-oriented training and lower limb rehabilitation robot can effectively improve the lower limb muscle strength, facilitate the recovery of balance function, and have a significant effect on the recovery of motor function, which can improve the walking ability of stroke patients and the range of motion of knee flexion, and achieve more ideal therapeutic effectiveness. 展开更多

关键词 Lower Limb Rehabilitation Robot Task-Oriented Training Stroke KFAROM

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Improvement in Mechanical Properties and Biocompatibility ofBiosynthetic Bacterial Cellulose/Lotus Root Starch Composites 认领 引用 被引量：2

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作者 Na Yin 陈仕艳 +2 位作者 Yi-meng Cao Hua-ping Wang 吴氢凯 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2017年第3期354-364,共11页

Bacterial cellulose/lotus root starch(BC/LRS) composites were prepared by cultivating Acetobacter xylinum in nutrient media containing gelatinized lotus root starch. Low concentrations of gelatinized LRS had increased... Bacterial cellulose/lotus root starch(BC/LRS) composites were prepared by cultivating Acetobacter xylinum in nutrient media containing gelatinized lotus root starch. Low concentrations of gelatinized LRS had increased BC production with the maximum value at 6.67 g/L when 5 g/L of LRS was added in the culture media and the composites had thicker and denser fibrils compared with those of BC with low concentrations of LRS(2.5 and 5 g/L). When the concentration of LRS was increased above 7.5 g/L, the morphology of the BC/LRS composites contained more fibril layers that were linked with LRS. The results from X-ray diffraction(XRD) demonstrated that there was no significant difference in structure between BC and BC/LRS composites except a slight increase in crystallinity for BC/LRS composites as the concentration of LRS was lifted up. The tensile tests were performed to display BC/LRS composites prepared with LRS concentration at 2.5 and 5 g/L in media had the tensile strength of 54 and 60 MPa, respectively, which indicated an improvement in mechanical property compared to the unmodified BC(45 MPa). Live/dead assay with chondrocytes seeded on BC/LRS composite revealed higher cell viability ranging from 85% to 90% than BC. Furthermore, cell morphology with typical spindle shape was observed on the surfaces of BC/LRS composite by confocal microscope. Through the overall results, it shows that this study has provided a guidance to prepare BC/LRS composites with better cell biocompatibility and higher mechanical strength than those of BC for the potential use in cartilage tissue engineering. 展开更多

关键词 Bacterial cellulose Lotus root starch Composites Biosynthesis Cell biocompatibility

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A Phase Estimation Algorithm for Quantum Speed-Up Multi-Party Computing 认领 引用

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作者 Wenbin Yu Hao Feng +3 位作者 Yinsong Xu Na Yin Yadang Chen Zhi-Xin Yang 《Computers, Materials & Continua》 SCIE EI 2021年第4期241-252,共12页

Security and privacy issues have attracted the attention of researchers in the field of IoT as the information processing scale grows in sensor networks.Quantum computing,theoretically known as an absolutely secure wa... Security and privacy issues have attracted the attention of researchers in the field of IoT as the information processing scale grows in sensor networks.Quantum computing,theoretically known as an absolutely secure way to store and transmit information as well as a speed-up way to accelerate local or distributed classical algorithms that are hard to solve with polynomial complexity in computation or communication.In this paper,we focus on the phase estimation method that is crucial to the realization of a general multi-party computing model,which is able to be accelerated by quantum algorithms.A novel multi-party phase estimation algorithm and the related quantum circuit are proposed by using a distributed Oracle operator with iterations.The proved theoretical communication complexity of this algorithm shows it can give the phase estimation before applying multi-party computing efficiently without increasing any additional complexity.Moreover,a practical problem of multi-party dating investigated shows it can make a successful estimation of the number of solution in advance with zero communication complexity by utilizing its special statistic feature.Sufficient simulations present the correctness,validity and efficiency of the proposed estimation method. 展开更多

关键词 Edge computing security multi-party computing quantum algorithm phase estimation communication complexity

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Collusion detector based on G-N algorithm for trust model 认领 引用

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作者 Lin Zhang Na Yin +1 位作者 Jingwen Liu Ruchuan Wang 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2016年第4期926-935,共10页

In the open network environment, malicious attacks to the trust model have become increasingly serious. Compared with single node attacks, collusion attacks do more harm to the trust model. To solve this problem, a co... In the open network environment, malicious attacks to the trust model have become increasingly serious. Compared with single node attacks, collusion attacks do more harm to the trust model. To solve this problem, a collusion detector based on the GN algorithm for the trust evaluation model is proposed in the open Internet environment. By analyzing the behavioral characteristics of collusion groups, the concept of flatting is defined and the G-N community mining algorithm is used to divide suspicious communities. On this basis, a collusion community detector method is proposed based on the breaking strength of suspicious communities. Simulation results show that the model has high recognition accuracy in identifying collusion nodes, so as to effectively defend against malicious attacks of collusion nodes. 展开更多

关键词 trust model collusion detector G-N algorithm

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Covalent metal-organic frameworks for cocatalyst-free photo-catalytic hydrogen production 认领 引用

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作者 Xiao Luo Ying-Qiang Li +7 位作者 Jie Luo Na Yin Yang-Min Lin Fangjie Xu Xu-Hang Zhong Chao-Fu Gou Guo-Hong Ning Dan Li 《Science China Chemistry》 SCIE EI CAS CSCD 2026年第4期1794-1800,共7页

Development of novel metal-organic framework(MOF)based photocatalysts for highly efficient hydrogen production from water or even seawater in the absence of noble metal as cocatalysts or photosensitizers,is highly dem... Development of novel metal-organic framework(MOF)based photocatalysts for highly efficient hydrogen production from water or even seawater in the absence of noble metal as cocatalysts or photosensitizers,is highly demand yet remains a significant challenge.Herein,we have synthesized four MOFs,namely n-OH-JNM(n=0,1,2,and 3),composed of copper-based cyclic trinuclear units(Cu-CTUs)and organic linkers with different numbers of-OH groups.By regulating the number of-OH groups,the optical properties,including light adsorption ability,band gap and charge separation efficiency,can be modulated,resulting in the dramatic improvement of photocatalytic hydrogen production rate.Specifically,in the absence of co-catalysts,2-OH-JNM can achieve a high hydrogen production rate of 4.07 and 1.49 mmol g^-1h^-1in pure water and natural seawater,respectively,while the other three JNMs cannot produce hydrogen under the same conditions.To the best of our knowledge,2-OH-JNM is currently the most efficient MOF-based photocatalyst in pure water for hydrogen production without any cocatalyst.Our work provides a new strategy for the development of noble-metal-free and co-catalyst-free MOF photocatalysts. 展开更多

关键词 covalent metal-organic frameworks(CMOFs) cyclic trinuclear units(CTUs) cocatalyst-free photocatalysis hydrogen production

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Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold 认领 引用 被引量：18

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作者 Fengwu Tang Jiaguang Tang +21 位作者 Yannan Zhao Jiaojiao Zhang Zhifeng Xiao Bing Chen Guang Han Na Yin Xianfeng Jiang Changyu Zhao Shixiang Cheng Ziqiang Wang Yumei Chen Qiaoling Chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang Chen Huilin Yang Shuxun Hou Sai Zhang Jianwu Dai 《Science China(Life Sciences)》 SCIE CAS CSCD 2022年第5期909-926,共18页

Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal mo... Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. 展开更多

关键词 complete spinal cord injury collagen scaffold function recovery clinical study

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A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma 认领 引用 被引量：14

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作者 Zhijia Lv Longhai Jin +8 位作者 Yue Cao Hao Zhang Dongzhi Xue Na Yin Tianqi Zhang Yinghui Wang Jianhua Liu Xiaogang Liu Hongjie Zhang 《Light: Science & Applications》 SCIE EI CSCD 2022年第6期1088-1097,共10页

The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their high invasiveness and blood-brain barrier(BBB)obstruction.It is highly desirable to find a multifunctional agent with good ... The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their high invasiveness and blood-brain barrier(BBB)obstruction.It is highly desirable to find a multifunctional agent with good BBB penetration for precise theranostics.Herein,we design and construct a core-shell structured nanotheranostic agent(YVO₄:Nd³⁺-HMME@MnO₂-LF,marked as YHM)with YVO₄∶Nd³⁺ particles as the core and MnO₂ nanosheets as the shell.Sonosensitizer hematoporphyrinmonomethyl ether(HMME)and lactoferrin(LF)were further loaded and modified on the surface,giving it a good ability to cross the BBB,near-infrared fluorescence imaging in the second window(NIR-Ⅱ)/magnetic resonance imaging(MRI)bimodality,and highly efficient sonodynamic therapy(SDT)of orthotopic gliomas.The YVO₄:Nd³⁺(25%)core exhibited good NIR-Ⅱ fluorescence properties,enabling YHM to act as promising probes for NIR-Ⅱ fluorescence imaging of vessels and orthotopic gliomas.MnO₂ shell can not only provide O2 in the tumor microenvironments(TME)to significantly improve the healing efficacy of SDT,but also release Mn²⁺ ions to achieve T1-weight MRI in situ.Non-invasive SDT can effectively restrain tumor growth.This work not only demonstrates that multifunctional YHM is promising for diagnosis and treatment of orthotopic glioma,but also provides insights into exploring the theranostic agents based on rare earth-doped yttrium vanadate nanoparticles. 展开更多

关键词 diagnosis agent barrier

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Novel multifunctional theranostic nanoagents based on Ho³⁺ for CT/MRI dual-modality imaging-guided photothermal therapy 认领 引用 被引量：2

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作者 Dongzhi Xue Yang Liu +10 位作者 Longhai Jin Yinghui Wang Fengzhi Cui Jianhua Liu Xiaoqing Li Songtao Zhang Ying Zhao Na Yin Rui Niu Daguang Wang Hongjie Zhang 《Science China Chemistry》 SCIE EI CAS CSCD 2021年第4期558-564,共7页

Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly effi... Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho³⁺.Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future. 展开更多

关键词 theranostics holmium dual-modality imaging photothermal therapy

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Initial performance results of the JUNO detector 认领 引用

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作者 Angel Abusleme Thomas Adam +1137 位作者 Kai Adamowicz David Adey Shakeel Ahmad Rizwan Ahmed Timo Ahola Sebastiano Aiello Fengpeng An Guangpeng An Costas Andreopoulos Giuseppe Andronico João Pedro Athayde Marcondes de André Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop Didier Auguste Margherita Buizza Avanzini Andrej Babic Jingzhi Bai Weidong Bai Nikita Balashov Roberto Barbera Andrea Barresi Davide Basilico Eric Baussan Beatrice Bellantonio Marco Bellato JeanLuc Beney Marco Beretta Antonio Bergnoli Enrico Bernieri Nikita Bessonov David Biaré Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld David Blum Simon Blyth Sara Boarin Manuel Boehles Anastasia Bolshakova Mathieu Bongrand Aurélie Bonhomme Clément Bordereau Matteo Borghesi Augusto Brigatti Timothee Brugiere Riccardo Brugnera Riccardo Bruno Jonas Buchholz Antonio Budano Max Buesken Mario Buscemi Severino Bussino Jose Busto Ilya Butorov Marcel Büchner Anatael Cabrera Barbara Caccianiga Boshuai Cai Hao Cai Xiao Cai Yanke Cai Yi-zhou Cai Zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Dechang Cai Chuanya Cao Dewen Cao Guofu Cao Jun Cao Yaoqi Cao Rossella Caruso Aurelio Caslini Cédric Cerna Vanessa Cerrone Daniele Cesini Chi Chan Jinfan Chang Yun Chang Milo Charavet Tim Charissé Auttakit Chatrabhuti Chao Chen Guoming Chen Haitao Chen Haotian Chen Jiahui Chen Jian Chen Jing Chen Junyou Chen Lihao Chen Mali Chen Mingming Chen Pingping Chen Po-An Chen Quanyou Chen Shaomin Chen Shenjian Chen Shi Chen Shiqiang Chen Sisi Chen Xin Chen Xuan Chen Xurong Chen Yi-Wen Chen Yiming Chen Yixue Chen Yu Chen Ze Chen Zelin Chen Zhang Chen Zhangming Chen Zhiyuan Chen Zhongchang Chen Zikang Chen Brian Cheng Jie Cheng Yaping Cheng Yu Chin Cheng Zhaokan Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti Yen-Ting Chin Pin-Jung Chiu Po-Lin Chou Ziliang Chu Artem Chukanov Neetu Raj Singh Chundawat Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Claudio Coletta Marta Colomer Molla Flavio Dal Corso Daniele Corti Salvatore Costa Simon Csakli Chenyang Cui Shanshan Cui Lorenzo Vincenzo D'Auria Olivia Dalager Jaydeep Datta Luis Delgadillo Franco Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Hanna Didenko Xiaoyu Ding Xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky David Doerflinger Tadeas Dohnal Maria Dolgareva Dmitry Dolzhikov Chuanshi Dong Haojie Dong Jianmeng Dong Lan Dong Damien Dornic Evgeny Doroshkevich Wei Dou Marcos Dracos Olivier Drapier Tobias Drohmann Frédéric Druillole Ran Du Shuxian Du Yujie Duan Katherine Dugas Stefano Dusini Hongyue Duyang Martin Dvorak Jessica Eck Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz Lukas Fajt Donghua Fan Lei Fan Liangqianjin Fan Can Fang Jian Fang Wenxing Fang Marco Fargetta Elia Stanescu Farilla Anna Fatkina Laurent Favart Dmitry Fedoseev Zhengyong Fei Franz von Feilitzsch Vladko Fekete Li-Cheng Feng Qichun Feng Shaoting Feng Giovanni Ferrante Federico Ferraro Daniela Fetzer Giovanni Fiorentini Andrey Formozov Marcellin Fotzé Amélie Fournier Sabrina Franke Arran Freegard Florian Fritsch Ying Fu Haonan Gan Feng Gao Ruixuan Gao Ruohan Gao Shijiao Gao Alberto Garfagnini Gerard Gaudiot Arsenii Gavrikov Raphaël Gazzini Christoph Genster Diwash Ghimire Marco Giammarchi Agnese Giaz Gianfranco Giordano Nunzio Giudice Franco Giuliani Alexandre Goettel Maxim Gonchar Guanda Gong Guanghua Gong Hui Gong Michel Gonin Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minhao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Rosa Maria Guizzetti Cong Guo Jingyuan Guo Wanlei Guo Yuhang Guo Paul Hackspacher Caren Hagner Hechong Han Ran Han Xiao Han Yang Han Ziguo Han Chuanhui Hao Jiajun Hao Vidhya Thara Hariharan JinCheng He Jinhong He Miao He Mingtao He Wei He Xinhai He Ziou He Tobias Heinz Dominikus Hellgartner Patrick Hellmuth Shilin Heng Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Zhilong Hou Fatima Houria Yee Hsiung Bei-Zhen Hu Hang Hu Hao Hu Jianrun Hu Jun Hu Peng Hu Tao Hu Wei Hu Yuxiang Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanyu Huang Hexiang Huang Jinhao Huang Junlin Huang Junting Huang Kairui Huang Kaixuan Huang Qinhua Huang Shengheng Huang Tao Huang Wenhao Huang Xiaozhong Huang Xin Huang Xingtao Huang Yongbo Huang Lian-Chen Huang Jiaqi Hui Lei Huo Cédric Huss Safeer Hussain Leonard Imbert Antonio Insolia Ara Ioannisian Daniel Ioannisyan Ammad Ul Islam Roberto Isocrate Adrienne Jacobi Arshak Jafar Beatrice Jelmini Kuo-Lun Jen Soeren Jetter Xiangpan Ji Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Yi Jia Cailian Jiang Chengbo Jiang Guangzheng Jiang Junjie Jiang Wei Jiang Xiaoshan Jiang Xiaozhao Jiang Yijian Jiang Yixuan Jiang Yue Jiang Ruyi Jin Shuzhu Jin Xiaoping Jing Cécile Jollet Liam Jones Jari Joutsenvaara Sirichok Jungthawan Philipp Kampmann Markus Kaiser Leonidas Kalousis Bowen Kan Li Kang Michael Karagounis Rebin Karaparambil Matej Karas Narine Kazarian Ali Khan Amir Khan Amina Khatun Khanchai Khosonthongkee Florian Kiel Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Zinovy Krumshteyn Andre Kruth Tim Kuhlbusch Sergey Kuleshov Sindhujha Kumaran Chun-Hao Kuo Nikolay Kutovskiy Pasi Kuusiniemi Loïc Labit Tobias Lachenmaier Haojing Lai ToUyen LamThi Philipp Landgraf Cecilia Landini Lorenzo Lastrucci Fedor Lazarev Sébastien Leblanc Victor Lebrin Matthieu Lecocq Priscilla Lecomte Frederic Lefevre Liping Lei Ruiting Lei Xiangcui Lei Rupert Leitner Petr Lenskii Jason Leung Bo Li Chao Li Daozheng Li Demin Li Dian Li Fei Li Fule Li Gaoshuang Li Gaosong Li Haitao Li Hongjian Li Huang Li Huiling Li Jiajun Li Jiaqi Li Jin Li Kaijie Li Meiou Li Mengzhao Li Min Li Nan Li Qingjiang Li Quanlin Li Ruhui Li Rui Li Shanfeng Li Shuaijie Li Shuo Li Tao Li Teng Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xiwen Li Xinying Li Yang Li Yawen Li Yi Li Yichen Li Yifan Li Yingke Li Yuanxia Li Yufeng Li Zepeng Li Zhaohan Li Zhibing Li Zhiwei Li Zi-Ming Li Ziyuan Li Zonghai Li An-An Liang Jing Liang Jingjing Liang Jiajun Liao Minghua Liao Yilin Liao Yuzhong Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Bo-Chun Lin Guey-Lin Lin Jiming Lin Shengxin Lin Tao Lin Xianhao Lin Xingyi Lin Yen-Hsun Lin Jiacheng Ling Jiajie Ling Xin Ling Ivano Lippi Caimei Liu Fang Liu Fengcheng Liu Gang Liu Haidong Liu Haotian Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hongyang Liu Hu Liu Hui Liu Jianglai Liu Jianli Liu Jiaxi Liu Jin'gao Liu Jinchang Liu Jinyan Liu Kainan Liu Lei Liu Libing Liu Mengchao Liu Menglan Liu Min Liu Qishan Liu Qian Liu Qin Liu Runxuan Liu Shenghui Liu Shuangyu Liu Shubing Liu Shulin Liu Wanjin Liu Xiaowei Liu Ximing Liu Xinkang Liu Xiwen Liu Xuewei Liu Yan Liu Yankai Liu Yin Liu Yiqi Liu Yuanyuan Liu Yuexiang Liu Yunzhe Liu Zhen Liu Zhipeng Liu Zhuo Liu Domenico Lo Presti Salvatore Loffredo Lorenzo Loi Paolo Lombardi Claudio Lombardo Yongbing Long Andrea Longhin Fabio Longhitano Kai Loo Sebastian Lorenz Selma Conforti Di Lorenzo Chuan Lu Fan Lu Haoqi Lu Jiashu Lu Junguang Lu Meishu Lu Peizhi Lu Shuxiang Lu Xianghui Lu Xianguo Lu Xiaoxu Lu Xiaoying Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Arslan Lukanov Daibin Luo Fengjiao Luo Guang Luo Jianyi Luo Pengwei Luo Shu Luo Tao Luo Wuming Luo Xiaojie Luo Xiaolan Luo Zhipeng Lv Vladimir Lyashuk Bangzheng Ma Bing Ma Na Ma Qiumei Ma Si Ma Wing Yan Ma Xiaoyan Ma Xubo Ma Santi Maensiri Jingyu Mai Romain Maisonobe Marco Malabarba Yury Malyshkin Roberto Carlos Mandujano Fabio Mantovani Xin Mao Yajun Mao Stefano MMari Cristina Martellini Agnese Martini Jacques Martino Johann Martyn Matthias Mayer Davit Mayilyan Worawat Meevasana Artur Meinusch Qingru Meng Yue Meng Anita Meraviglia Anselmo Meregaglia Emanuela Meroni David Meyhöfer Jian Min Lino Miramonti Nikhil Mohan Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Iwan Morton-Blake Xiangyi Mu Pavithra Muralidharan Lakshmi Murgod Axel Müller Thomas Mueller Massimiliano Nastasi Dmitry VNaumov Elena naumova Diana navas-Nicolas Igor Nemchenok Elisabeth Neuerburg VanHung Nguyen Dennis Nielinger Alexey Nikolaev Feipeng Ning Zhe Ning Yujie Niu Stepan Novikov Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Samantha Cantu Olea Sebastian Olivares Alexander Olshevskiy Domizia Orestano Fausto Ortica Rainer Othegraven Yifei Pan Alessandro Paoloni Nina Parkalian George Parker Sergio Parmeggiano Achilleas Patsias Teerapat Payupol Viktor Pec Davide Pedretti Yatian Pei Luca Pelicci Nicomede Pelliccia Anguo Peng Haiping Peng Yu Peng Zhaoyuan Peng Elisa Percalli Willy Perrin Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Min Pi Oliver Pilarczyk Ruben Pompilio Artyom Popov Pascal Poussot Stefano Pozzi Wathan Pratumwan Ezio Previtali Sabrina Prummer Fazhi Qi Ming Qi Xiaohui Qi Sen Qian Xiaohui Qian Zhen Qian Liqing Qin Zhonghua Qin Shoukang Qiu Manhao Qu Zhenning Qu Muhammad Usman Rajput Shivani Ramachandran Gioacchino Ranucci Neill Raper Reem Rasheed Thomas Raymond Alessandra Re Henning Rebber Abdel Rebii Bin Ren Shanjun Ren Yuhan Ren Andrea Rendina Cristobal Morales Reveco Taras Rezinko Barbara Ricci Luis Felipe Piñeres Rico Mariam Rifai Markus Robens Mathieu Roche Narongkiat Rodphai Fernanda de Faria Rodrigues Lars Rohwer Aldo Romani Vincent Rompel Bedřich Roskovec Xiangdong Ruan Xichao Ruan Peter Rudakov Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Sahar Safari Giuseppe Salamanna Deshan Sandanayake Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Ujwal Santhosh Giuseppe Sava Utane Sawangwit Julia Sawatzki Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Ikram Shahzad Yanjun Shan Junyu Shao Zhuang Shao Anurag Sharma Vladislav Sharov Arina Shaydurova Wei Shen Gang Shi Hangyu Shi Hexi Shi Jingyan Shi Yanan Shi Yongjiu Shi Yuan Shi Dmitrii Shpotya Yike Shu Yuhan Shu She Shuai Vitaly Shutov Andrey Sidorenkov Randhir Singh Apeksha Singhal Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Michael Soiron Sergey Sokolov Julanan Songwadhana Boonrucksar Soonthornthum Felix Sorgenfrei Albert Sotnikov Mario Spinetti Warintorn Sreethawong Achim Stahl Luca Stanco Korbinian Stangler Konstantin Stankevich Hans Steiger Jochen Steinmann Malte Stender Tobias Sterr David Stipp Matthias Raphael Stock Virginia Strati Mikhail Strizh Alexander Studenikin Katharina von Sturm Aoqi Su Jun Su Yuning Su Gongxing Sun Guangbao Sun Hansheng Sun Lijun Sun Liting Sun Mingxia Sun Shifeng Sun Xilei Sun Yongzhao Sun Yunhua Sun Yuning Sun Zhanxue Sun Zhengyang Sun Narumon Suwonjandee Troy Swift Michal Szelezniak DušanŠtefánik FedorŠimkovic OndřejŠrámek Dmitriy Taichenachev Christophe De La Taille Akira Takenaka Hongnan Tan Xiaohan Tan Haozhong Tang Jian Tang Jingzhe Tang Qiang Tang Quan Tang Xiao Tang Jihua Tao Eric Theisen Minh Thuan Nguyen Thi Renju Tian Yuxin Tian Alexander Tietzsch Igor Tkachev Tomas Tmej Marco Danilo Claudio Torri Francesco Tortorici Konstantin Treskov Andrea Triossi Wladyslaw Trzaska Andrei Tsaregorodtsev Alexandros Tsagkarakis Yu-Chen Tung Cristina Tuve Nikita Ushakov Guillaume Vanroyen Nikolaos Vassilopoulos Carlo Venettacci Giuseppe Verde Maxim Vialkov Benoit Viaud Cornelius Moritz Vollbrecht Vit Vorobel Dmitriy Voronin Lucia Votano Stefan van Waasen Stefan Wagner Pablo Walker Jiawei Wan Andong Wang Caishen Wang Chung-Hsiang Wang Cui Wang Derun Wang En Wang Guoli Wang Hanwen Wang Hongxin Wang Huanling Wang Jiabin Wang Jian Wang Jun Wang Ke Wang Kunyu Wang Lan Wang Li Wang Lu Wang Meifen Wang Meng Wang Meng Wang Mingyuan Wang Qianchuan Wang Ruiguang Wang Sibo Wang Siguang Wang Tianhong Wang Tong Wang Wei Wang Wei Wang Wenshuai Wang Wenwen Wang Wenyuan Wang Xi Wang Xiangyue Wang Xuesen Wang Yangfu Wang Yaoguang Wang Yi Wang Yi Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Yuyi Wang Zhe Wang Zheng Wang Zhigang Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Junya Wei Jushang Wei Lianghong Wei Wei Wei Wei Wei Wenlu Wei Yadong Wei Yuehuan Wei Zhengbao Wei Marcel Weifels Kaile Wen Liangjian Wen Yijie Wen Jun Weng Christopher Wiebusch Rosmarie Wirth Steven Chan-Fai Wong Bjoern Wonsak Baona Wu Bi Wu Chengxin Wu Chia-Hao Wu Chin-Wei Wu Diru Wu Fangliang Wu Jianhua Wu Qun Wu Shuai Wu Wenjie Wu Yinhui Wu Yiyang Wu Zhaoxiang Wu Zhi Wu Zhongyi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Jingkai Xia Shishen Xian Ziqian Xiang Fei Xiao Pengfei Xiao Tianying Xiao Xiang Xiao Wan Xie Wei-Jun Xie Xiaochuan Xie Yijun Xie Yuguang Xie Zhangquan Xie Zhao Xin Zhizhong Xing Benda Xu Cheng Xu Chuang Xu Donglian Xu Fanrong Xu Hangkun Xu Jiayang Xu Jie Xu Jilei Xu Jinghuan Xu Lingyu Xu Meihang Xu Shiwen Xu Xunjie Xu Ya Xu Yin Xu Yu Xu Dongyang Xue Jingqin Xue Baojun Yan Liangping Yan Qiyu Yan Taylor Yan Tian Yan Wenqi Yan Xiongbo Yan Yupeng Yan Anbo Yang Caihong Yang Changgen Yang Chengfeng Yang Dikun Yang Dingyong Yang Fengfan Yang Haibo Yang Huan Yang Jie Yang Jize Yang Kaiwei Yang Lei Yang Mengting Yang Pengfei Yang Xiaoyu Yang Xuhui Yang Yi Yang Yichen Yang Yifan Yang Yixiang Yang Yujiao Yang Yuzhen Yang Zekun Yang Haifeng Yao Li Yao Jiaxuan Ye Mei Ye Xingchen Ye Ziping Ye Ugur Yegin Frédéric Yermia Peihuai Yi Rattikorn Yimnirun Jilong Yin Na Yin Weiqing Yin Xiangwei Yin Xiaohao Yin Sivaram Yogathasan Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Guangyou Yu Guojun Yu Hongzhao Yu Miao Yu Peidong Yu Simi Yu Xianghui Yu Yang Yu Zeyuan Yu Zezhong Yu Cenxi Yuan Chengzhuo Yuan Zhaoyang Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar AndréZambanini Jilberto Zamora Matteo Zanetti Vitalii Zavadskyi Fanrui Zeng Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Yujie Zeng Liang Zhan Aiqiang Zhang Bin Zhang Binting Zhang Chengcai Zhang Enze Zhang Feiyang Zhang Guoqing Zhang Haiqiong Zhang Han Zhang Hangchang Zhang Haosen Zhang Honghao Zhang Hongmei Zhang Jialiang Zhang Jiawen Zhang Jie Zhang Jin Zhang Jingbo Zhang Jinnan Zhang Junwei Zhang Kun Zhang Lei Zhang Mingxuan Zhang Mohan Zhang Peng Zhang Ping Zhang Qingmin Zhang Rongping Zhang Rui Zhang Shaoping Zhang Shiqi Zhang Shu Zhang Shuihan Zhang Siyuan Zhang Tao Zhang Xiaofeng Zhang Xiaomei Zhang Xin Zhang Xu Zhang Xuan Zhang Xuantong Zhang Xuesong Zhang Xueyao Zhang Yan Zhang Yibing Zhang Yinhong Zhang Yiyu Zhang Yizhou Zhang Yongjie Zhang Yongpeng Zhang Yu Zhang Yuanyuan Zhang Yue Zhang Yueyuan Zhang Yumei Zhang Yuning Zhang Zhenyu Zhang Zhicheng Zhang Zhijian Zhang Zhixuan Zhang Baoqi Zhao Fengyi Zhao Jie Zhao Liang Zhao Mei Zhao Rong Zhao Runze Zhao Shujun Zhao Tianchi Zhao Tianhao Zhao Yubin Zhao Dongqin Zheng Hua Zheng Xiangyu Zheng Yangheng Zheng Weili Zhong Weirong Zhong Albert Zhou Guorong Zhou Li Zhou Lishui Zhou Min Zhou Shun Zhou Tong Zhou Xiang Zhou Xing Zhou Yan Zhou Haiwen Zhu Jiang Zhu Jingsen Zhu Jingyu Zhu Kangfu Zhu Kejun Zhu Zhihang Zhu Ivan Zhutikov Bo Zhuang Honglin Zhuang Liang Zong Jiaheng Zou Sebastian Zwickel Jan Züfle JUNO Collaboration 《Chinese Physics C》 SCIE CAS CSCD 2026年第4期1-31,共31页

The Jiangmen Underground Neutrino Observatory(JUNO)started physics data taking on 26 August 2025.JUNO consists of a 20-kton liquid scintillator central detector,surrounded by a 35 kton water pool serving as a Cherenko... The Jiangmen Underground Neutrino Observatory(JUNO)started physics data taking on 26 August 2025.JUNO consists of a 20-kton liquid scintillator central detector,surrounded by a 35 kton water pool serving as a Cherenkov veto,and almost 1000 m² of plastic scintillator veto on top.The detector is located in a shallow underground laboratory with an overburden of 1800 m.w.e.This paper presents the performance results of the detector,extensively studied during the commissioning of the water phase,the subsequent liquid scintillator filling phase,and the first physics runs.The liquid scintillator achieved an attenuation length of 20.6 m at 430 nm,while the high coverage PMT system and scintillator together yielded about 1785 photoelectrons per MeV of energy deposit at the detector centre,measured using the 2.223 MeVγfrom neutron captures on hydrogen with an Am-C calibration source.The reconstructed energy resolution is 3.4%for two 0.511 MeVγat the detector centre and 2.9%for the 0.93 MeV quenched ²¹⁴Po alpha decays from natural radioactive sources.The energy non-linearity is calibrated to better than 1%.Intrinsic contaminations of ²³⁸U and ²³²Th in the liquid scintillator are below 10^-16 g/g,assuming secular equilibrium.The water Cherenkov detector achieves a muon detection efficiency better than 99.9%for muons traversing the liquid scintillator volume.During the initial science runs,the data acquisition duty cycle exceeded 97.8%,demonstrating the excellent stability and readiness of JUNO for high-precision neutrino physics. 展开更多

关键词 neutrino oscillations JUNO detector performance

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Targeted protein degradation via chimeric antigen receptor(CAR)-mediated antigen endocytosis in T cells 认领 引用

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作者 Youguang Wang Zihao He +1 位作者 Na Yin Min Peng 《hLife》 CSCD 2026年第7期423-438,共16页

Targeted protein degradation(TPD)holds significant therapeutic potential over conventional biologics.However,existing platforms are constrained by their reliance on host protein degradation machinery and limited durab... Targeted protein degradation(TPD)holds significant therapeutic potential over conventional biologics.However,existing platforms are constrained by their reliance on host protein degradation machinery and limited durability,rendering them inadequate for chronic diseases requiring sustained treatment.Here,we constructed a chimeric antigen receptor(CAR)incorporating the TNFR1 ectodomain as the antigen-binding domain(TNFR1T cells)and used CRISPR-mediated knockout of BCOR and ZC3H12A to generate persistent TNFR1T IF cells.TNF binding,endocytosis,and degradation were assessed in vitro by flow cytometry and immunofluorescence.Immunocompetent syngeneic,Tnf^-/-,and hTNF-tg rheumatoid arthritis(RA)mice(n=4-9)were used in vivo to evaluate engraftment,persistence,and disease severity(clinical scoring and grip strength),with adalimumab(Humira,1 or 10 mg/kg)as a comparator.Safety was assessed by intravenous Listeria monocytogenes challenge(1×10⁴ colony-forming units[CFU],n=6)and Thy1.1-based depletion(0.25 mg,n=3).We found that TNFR1T cells specifically bound,endocytosed,and degraded soluble TNF in vitro.Without lymphodepletion preconditioning,TNFR1T IF cells expanded and persisted for one year in immunocompetent mice.A single infusion into hTNF-tg mice reduced serum hTNF to near wild-type levels,preventing and treating all stages of RA with superior efficacy and durability than the repeated high-dose adalimumab.Antibacterial defense remained uncompromised,and anti-Thy1.1 antibody efficiently eliminated TNFR1T IF cells in vivo.This approach extends CAR-T cell targeting from cellular antigens to soluble extracellular proteins,establishing a host-machinery-independent,durable cellular-TPD platform for chronic inflammatory diseases. 展开更多

关键词 targeted protein degradation(TPD) chimeric antigen receptor(CAR)-T cells soluble antigen endocytosis BCOR ZC3H12A rheumatoid arthritis