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Dioxygenase RhDAO1 regulates floral organ identity by controlling auxin homeostasis in miniature rose(Rosa hybrida) 认领 引用
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作者 Wen Chen Zheyuan Ding +3 位作者 Yuanji Shen Yingying Zhou Ping Luo Yongyi Cui 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第5期1185-1203,共19页
Miniature rose(Rosa hybrida)is one of the most extensively cultivated ornamental plants worldwide,and the double-flower traits strongly enhance its aesthetic value.However,the regulatory mechanisms underlying petal nu... Miniature rose(Rosa hybrida)is one of the most extensively cultivated ornamental plants worldwide,and the double-flower traits strongly enhance its aesthetic value.However,the regulatory mechanisms underlying petal number variation remain unclear.In this study,we conducted comparative transcriptomic analysis of floral buds in miniature rose'Eclair'and its bud sport‘Konkyusare,'which have increased petaloid stamens.We identified a crucial differentially expressed gene,RhDAO1,encoding an auxin-catabolising dioxygenase.RhDAO1 expression was significantly higher during early floral bud development in'Eclair'than in'Konkyusare'and showed an inverse correlation with indole-3-acetic acid(IAA)accumulation.Transient overexpression of RhDAO1 in rose petals resulted in a significant reduction in the levels of IAA and its catabolite IAA-Asp.RhDAO1 silencing in rose plants increased petaloid stamens while reducing normal stamen count.Furthermore,RhDAO1 significantly altered the expression patterns of key floral organ identity genes,including RhAP2,RhAG,RhSHP1,and auxin signalling components.In situ hybridisation and IAA immunolocalisation showed that RhDAO1transcripts colocalised with IAA accumulation maxima in developing floral organ primordia,and silenced buds exhibited elevated endogenous IAA.Exogenous IAA treatment partially mimicked the RhDAO1-silenced phenotype by promoting stamen-to-petal conversion in‘Eclair'.Meanwhile,the auxin transport inhibitor N-1-naphthylphthalamic acid(NPA)treatment decreased petal number in'Konkyusare'.Collectively,our results demonstrate that Rh DAO1 fine-tunes floral organ identity through spatiotemporal regulation of auxin homeostasis and transcriptional control of floral organ identity genes,providing insights for refining double-flower traits in rose breeding programmes. 展开更多
关键词 Rosa hybrida RhDAO1 Double flower Auxin Stamen petaloidy
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A feedback loop comprising RhMYB114 and RhMYB16 regulates anthocyanin accumulation and tissue acidification in Rosa hybrida 认领 引用 被引量：3
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作者 Yeni Chen Guoyuan Shao +3 位作者 Linmei Chen Huanyu Zhang Yongyi Cui Ping Luo 《Horticultural Plant Journal》 SCIE CAS CSCD 2025年第6期2194-2210,共17页
Coloration in rose(Rosa hybrida) petals is primarily determined by anthocyanin accumulation in vacuoles, and vacuolar acidification plays a central role in controlling the accumulation of this pigment. Nevertheless, t... Coloration in rose(Rosa hybrida) petals is primarily determined by anthocyanin accumulation in vacuoles, and vacuolar acidification plays a central role in controlling the accumulation of this pigment. Nevertheless, the regulatory interplay between anthocyanin accumulation and tissue acidification processes remains somewhat unclear. The present study characterized an activator Rh MYB114 and a repressor Rh MYB16,which functioned synergistically in anthocyanin accumulation and tissue acidification in rose. Transforming tobacco and roses by overexpression, the introduction of Rh MYB114 resulted in an increase in anthocyanin levels and a noticeable decrease in p H in the petal cells of both rose and tobacco, whereas Rh MYB16 introduction led to inverse effects. To further clarify the underlying the regulatory mechanisms, the yeast two-hybrid(Y2H), bimolecular fluorescence complementation(Bi FC) and dual-luciferase(LUC) were employed. The results showed that Rh MYB16 competed with Rh MYB114, bound to Rhb HLH3 or Rhb HLH33, and inhibited its ability to induce the expression of genes related to anthocyanin biosynthesis and acidification. Our findings revealed a feedback mechanism for the regulation of anthocyanin synthesis and tissue acidification involving Rh MYB114, which stimulated the transcriptional expression of Rh MYB16, whose encoded protein Rh MYB16, in turn, negatively regulated the transcriptional expression of Rh MYB114. Therefore, this study underscores the pivotal roles of the Rh MYB114-Rh MYB16 loop in regulating anthocyanin synthesis and tissue acidification, offering insights into metabolic manipulation to enhance the aesthetic appeal of roses. 展开更多
关键词 Rosa hybrida RhMYB114 RhMYB16 Anthocyanin biosynthesis Tissue acidification Feedback regulation
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第三代测序技术在神经元核内包涵体病重复序列检测实践中的应用 认领 引用
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作者 李晓文 刘庆 +10 位作者 陈鹏 罗萍 田锦 唐春燕 余艳 汤媛媛 莫南勋 李慧源 喻长顺 程凯汀 陈浩 《阿尔茨海默病及相关病杂志》 2026年第1期19-24,30,共6页
目的:评估第三代测序(TGS)技术在临床检测神经元核内包涵体病(NIID)NOTCH2NLC基因GGC重复序列中的优势。方法:收集2017年1月至2023年12月于徐州医科大学附属医院神经内科确诊的NIID患者(确诊组,n=10)、临床疑似但未确诊者(疑似组,n=10)... 目的:评估第三代测序(TGS)技术在临床检测神经元核内包涵体病(NIID)NOTCH2NLC基因GGC重复序列中的优势。方法:收集2017年1月至2023年12月于徐州医科大学附属医院神经内科确诊的NIID患者(确诊组,n=10)、临床疑似但未确诊者(疑似组,n=10)及健康对照者(对照组,n=10)的外周血样本。采用长距离PCR(LR-PCR)及重复引物PCR(RP-PCR)扩增NOTCH2NLC基因GGC重复序列,通过毛细管电泳(CE)进行初筛,阳性样本进一步采用TGS技术(PacBio Sequel IIe平台)验证,并对比两种方法的重复序列检测能力。结果:确诊组10例样本经CE复测均检出GGC重复序列,其中2例重复数>110的样本无法确定GGC重复数量;疑似组NIID的10例样本中,CE检出4例存在可疑重复序列(其中2例重复数>110无法定量)。TGS对14例CE阳性样本均给出精确重复数,包括CE未能定量的4例高重复样本。两种方法均未提示假阳性和假阴性的状况。结论:TGS能够有效克服CE在NIID高重复序列定量中的技术局限,实现精准定量并解析序列结构,为NIID的分子分型与精准诊疗提供更可靠的技术支持。 展开更多
关键词 神经元核内包涵体病 重复序列检测 毛细管电泳 第三代测序
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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial 认领 引用 被引量：12
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作者 Jie Wu Shu-wei Duan +41 位作者 Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen 《Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第2期111-119,共9页
Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety ... Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. 展开更多
关键词 Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy
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Traditional Chinese Medicine for the treatment of influenza: a systematic review and Meta-analysis of randomized controlled trials 认领 引用 被引量：5
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作者 Chunya Wang Hao Wang +3 位作者 Xinying Liu Dongping Xu Yiping Tang Ping Luo 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2014年第5期527-531,共5页
OBJECTIVE: To justify the clinical use of Traditional Chinese Medicine(TCM) in the treatment of influenza.METHODS: MEDLINE, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Datab... OBJECTIVE: To justify the clinical use of Traditional Chinese Medicine(TCM) in the treatment of influenza.METHODS: MEDLINE, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database and the Cochrane Database of Systematic Reviews were searched from thedate of inception until January 1,2013, for the literature on treatment of influenza with TCM.RESULTS: A total of 7 randomized controlled trials were identified and reviewed. Of these trials, 2 compared a(modified) prescription of TCM with oseltamivir and 5 compared a patent traditional Chinese drug with oseltamivir. Based on the Meta-analysis,compared to oseltamivir, the(modified) prescription had similar effect in defervescence [WMD=5.66, 95% CI(﹣32.02, 43.35), P=0.77] and viral shedding [WMD=﹣ 6.21, 95% CI(﹣84.19, 71.76), P=0.88], and the patent traditional Chinese drug also had similar effect in viral shedding [WMD=﹣ 0.24,95% CI(﹣4.79, 4.31), P=0.92] but more effective in defervescence [WMD=﹣4.65, 95%CI(﹣8.91, ﹣0.38),P=0.03].CONCLUSION: TCM has potential positive effects in the treatment of influenza. 展开更多
关键词 Influenza, human Medicine, ChineseTraditional Oseltamivir Systematic review Ran-domized controlled trials
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Cooperative Detection Method for DDoS Attacks Based on Blockchain 认领 引用 被引量：3
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作者 Jieren Cheng Xinzhi Yao +6 位作者 Hui Li Hao Lu Naixue Xiong Ping Luo Le Liu Hao Guo Wen Feng 《Computer Systems Science & Engineering》 SCIE EI 2022年第10期103-117,共15页
Distributed Denial of Service(DDoS)attacks is always one of the major problems for service providers.Using blockchain to detect DDoS attacks is one of the current popular methods.However,the problems of high time over... Distributed Denial of Service(DDoS)attacks is always one of the major problems for service providers.Using blockchain to detect DDoS attacks is one of the current popular methods.However,the problems of high time overhead and cost exist in the most of the blockchain methods for detecting DDoS attacks.This paper proposes a blockchain-based collaborative detection method for DDoS attacks.First,the trained DDoS attack detection model is encrypted by the Intel Software Guard Extensions(SGX),which provides high security for uploading the DDoS attack detection model to the blockchain.Secondly,the service provider uploads the encrypted model to Inter Planetary File System(IPFS)and then a corresponding Content-ID(CID)is generated by IPFS which greatly saves the cost of uploading encrypted models to the blockchain.In addition,due to the small amount of model data,the time cost of uploading the DDoS attack detection model is greatly reduced.Finally,through the blockchain and smart contracts,the CID is distributed to other service providers,who can use the CID to download the corresponding DDoS attack detection model from IPFS.Blockchain provides a decentralized,trusted and tamper-proof environment for service providers.Besides,smart contracts and IPFS greatly improve the distribution efficiency of the model,while the distribution of CID greatly improves the efficiency of the transmission on the blockchain.In this way,the purpose of collaborative detection can be achieved,and the time cost of transmission on blockchain and IPFS can be considerably saved.We designed a blockchain-based DDoS attack collaborative detection framework to improve the data transmission efficiency on the blockchain,and use IPFS to greatly reduce the cost of the distribution model.In the experiment,compared with most blockchain-based method for DDoS attack detection,the proposed model using blockchain distribution shows the advantages of low cost and latency.The remote authentication mechanism of Intel SGX provides high security and integrity,and ensures the availability of distributed models. 展开更多
关键词 Blockchain smart contract IPFS DDoS attack
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GrCol-PPFL:User-Based Group Collaborative Federated Learning Privacy Protection Framework 认领 引用 被引量：3
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作者 Jieren Cheng Zhenhao Liu +2 位作者 Yiming Shi Ping Luo Victor S.Sheng 《Computers, Materials & Continua》 SCIE EI 2023年第1期1923-1939,共17页
With the increasing number of smart devices and the development of machine learning technology,the value of users’personal data is becoming more and more important.Based on the premise of protecting users’personal p... With the increasing number of smart devices and the development of machine learning technology,the value of users’personal data is becoming more and more important.Based on the premise of protecting users’personal privacy data,federated learning(FL)uses data stored on edge devices to realize training tasks by contributing training model parameters without revealing the original data.However,since FL can still leak the user’s original data by exchanging gradient information.The existing privacy protection strategy will increase the uplink time due to encryption measures.It is a huge challenge in terms of communication.When there are a large number of devices,the privacy protection cost of the system is higher.Based on these issues,we propose a privacy-preserving scheme of user-based group collaborative federated learning(GrCol-PPFL).Our scheme primarily divides participants into several groups and each group communicates in a chained transmission mechanism.All groups work in parallel at the same time.The server distributes a random parameter with the same dimension as the model parameter for each participant as a mask for the model parameter.We use the public datasets of modified national institute of standards and technology database(MNIST)to test the model accuracy.The experimental results show that GrCol-PPFL not only ensures the accuracy of themodel,but also ensures the security of the user’s original data when users collude with each other.Finally,through numerical experiments,we show that by changing the number of groups,we can find the optimal number of groups that reduces the uplink consumption time. 展开更多
关键词 Federated learning privacy protection uplink consumption time
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Risk factors for mortality within 6 mo in patients with diabetes undergoing urgent-start peritoneal dialysis:A multicenter retrospective cohort study 认领 引用 被引量：1
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作者 Si-Yu Cheng Li-Ming Yang +7 位作者 Zhan-Shan Sun Xiao-Xuan Zhang Xue-Yan Zhu Ling-Fei Meng Shi-Zheng Guo Xiao-Hua Zhuang Ping Luo Wen-Peng Cui 《World Journal of Diabetes》 SCIE 2022年第4期376-386,共11页
BACKGROUND The risk of early mortality of patients who start dialysis urgently is high;however,in patients with diabetes undergoing urgent-start peritoneal dialysis(USPD),the risk of,and risk factors for,early mortali... BACKGROUND The risk of early mortality of patients who start dialysis urgently is high;however,in patients with diabetes undergoing urgent-start peritoneal dialysis(USPD),the risk of,and risk factors for,early mortality are unknown.AIM To identify risk factors for mortality during high-risk periods in patients with diabetes undergoing USPD.METHODS This retrospective cohort study enrolled 568 patients with diabetes,aged≥18 years,who underwent USPD at one of five Chinese centers between 2013 and 2019.We divided the follow-up period into two survival phases:The first 6 mo of USPD therapy and the months thereafter.We compared demographic and baseline clinical data of living and deceased patients during each period.Kaplan-Meier survival curves were generated for all-cause mortality according to the New York Heart Association(NYHA)classification.A multivariate Cox proportional hazard regression model was used to identify risk factors for mortality within the first 6 mo and after 6 mo of USPD.RESULTS Forty-one patients died within the first 6 mo,accounting for the highest proportion of mortalities(26.62%)during the entire follow-up period.Cardiovascular disease was the leading cause of mortality within 6 mo(26.83%)and after 6 mo(31.86%).The risk of mortality not only within the first 6 mo but also after the first 6 mo was higher for patients with obvious baseline heart failure symptoms than for those with mild or no heart failure symptoms.Independent risk factors for mortality within the first 6 mo were advanced age hazard ratio(HR:1.908;95%CI:1.400-2.600;P<0.001),lower baseline serum creatinine level(HR:0.727;95%CI:0.614-0.860;P<0.001),higher baseline serum phosphorus level(HR:3.162;95%CI:1.848-5.409;P<0.001),and baseline NYHA class III-IV(HR:2.148;95%CI:1.063-4.340;P=0.033).Independent risk factors for mortality after 6 mo were advanced age(HR:1.246;95%CI:1.033-1.504;P=0.022)and baseline NYHA class III-IV(HR:2.015;95%CI:1.298-3.130;P=0.002).CONCLUSION To reduce the risk of mortality within the first 6 mo of USPD in patients with diabetes,controlling the serum phosphorus level and improving cardiac function are recommended。 展开更多
关键词 Peritoneal dialysis Urgent start Diabetes mellitus,Mortality within the first 6 mo Risk factor End-stage renal disease
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A Learning Particle Swarm Optimization Algorithm for Odor Source Localization 认领 引用 被引量：5
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作者 Qiang Lu Ping Luo 《International Journal of Automation and computing》 2011年第3期371-380,共10页
This paper is concerned with the problem of odor source localization using multi-robot system.A learning particle swarm optimization algorithm,which can coordinate a multi-robot system to locate the odor source,is pro... This paper is concerned with the problem of odor source localization using multi-robot system.A learning particle swarm optimization algorithm,which can coordinate a multi-robot system to locate the odor source,is proposed.First,in order to develop the proposed algorithm,a source probability map for a robot is built and updated by using concentration magnitude information,wind information,and swarm information.Based on the source probability map,the new position of the robot can be generated.Second,a distributed coordination architecture,by which the proposed algorithm can run on the multi-robot system,is designed.Specifically,the proposed algorithm is used on the group level to generate a new position for the robot.A consensus algorithm is then adopted on the robot level in order to control the robot to move from the current position to the new position.Finally,the effectiveness of the proposed algorithm is illustrated for the odor source localization problem. 展开更多
关键词 Multi-robot system odor source localization particle swarm optimization source probability map distributed coordination architecture.
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MPFracNet:A Deep Learning Algorithm for Metacarpophalangeal Fracture Detection with Varied Difficulties 认领 引用
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作者 Geng Qin Ping Luo +5 位作者 Kaiyuan Li Yufeng Sun Shiwei Wang Xiaoting Li Shuang Liu Linyan Xue 《Computers, Materials & Continua》 SCIE EI 2023年第4期999-1015,共17页
Due to small size and high occult,metacarpophalangeal fracturediagnosis displays a low accuracy in terms of fracture detection and locationin X-ray images.To efficiently detect metacarpophalangeal fractures on Xrayima... Due to small size and high occult,metacarpophalangeal fracturediagnosis displays a low accuracy in terms of fracture detection and locationin X-ray images.To efficiently detect metacarpophalangeal fractures on Xrayimages as the second opinion for radiologists,we proposed a novel onestageneural network namedMPFracNet based onRetinaNet.InMPFracNet,a deformable bottleneck block(DBB)was integrated into the bottleneckto better adapt to the geometric variation of the fractures.Furthermore,an integrated feature fusion module(IFFM)was employed to obtain morein-depth semantic and shallow detail features.Specifically,Focal Loss andBalanced L1 Loss were introduced to respectively attenuate the imbalancebetween positive and negative classes and the imbalance between detectionand location tasks.We assessed the proposed model on the test set andachieved an AP of 80.4%for the metacarpophalangeal fracture detection.To estimate the detection performance for fractures with different difficulties,the proposed model was tested on the subsets of metacarpal,phalangeal andtiny fracture test sets and achieved APs of 82.7%,78.5%and 74.9%,respectively.Our proposed framework has state-of-the-art performance for detectingmetacarpophalangeal fractures,which has a strong potential application valuein practical clinical environments. 展开更多
关键词 Deep learning small object detection metacarpophalangeal fractures computer-aided diagnosis(CAD)
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Comparison of clinical features and outcomes in peritoneal dialysisassociated peritonitis patients with and without diabetes:A multicenter retrospective cohort study 认领 引用 被引量：15
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作者 Ling-Fei Meng Li-Ming Yang +7 位作者 Xue-Yan Zhu Xiao-Xuan Zhang Xin-Yang Li Jing Zhao Shi-Chen Liu Xiao-Hua Zhuang Ping Luo Wen-Peng Cui 《World Journal of Diabetes》 SCIE 2020年第10期435-446,共12页
BACKGROUND The number of end-stage renal disease patients with diabetes mellitus(DM)who are undergoing peritoneal dialysis is increasing.Peritoneal dialysis-associated peritonitis(PDAP)is a serious complication of per... BACKGROUND The number of end-stage renal disease patients with diabetes mellitus(DM)who are undergoing peritoneal dialysis is increasing.Peritoneal dialysis-associated peritonitis(PDAP)is a serious complication of peritoneal dialysis leading to technical failure and increased mortality in patients undergoing peritoneal dialysis.The profile of clinical symptoms,distribution of pathogenic organisms,and response of PDAP to medical management in the subset of end-stage renal disease patients with DM have not been reported previously.Discrepant results have been found in long-term prognostic outcomes of PDAP in patients with DM.We inferred that DM is associated with bad outcomes in PDAP patients.AIM To compare the clinical features and outcomes of PDAP between patients with DM and those without.METHODS In this multicenter retrospective cohort study,we enrolled patients who had at least one episode of PDAP during the study period.The patients were followed for a median of 31.1 mo.They were divided into a DM group and a non-DM group.Clinical features,therapeutic outcomes,and long-term prognostic outcomes were compared between the two groups.Risk factors associated with therapeutic outcomes of PDAP were analyzed using multivariable logistic regression.A Cox proportional hazards model was constructed to examine the influence of DM on patient survival and incidence of technical failure.RESULTS Overall,373 episodes occurred in the DM group(n=214)and 692 episodes occurred in the non-DM group(n=395).The rates of abdominal pain and fever were similar in the two groups(P>0.05).The DM group had more infections with coagulase-negative Staphylococcus and less infections with Escherichia coli(E.coli)as compared to the non-DM group(P0.05).Patients in the DM group were older and had a higher burden of cardiovascular disease,with lower level of serum albumin,but a higher estimated glomerular filtration rate(P0.05).CONCLUSION PDAP patients with diabetes have similar symptomology and are predisposed to coagulase-negative Staphylococcus but not E.coli infection compared those without.Diabetes is associated with higher all-cause mortality but not therapeutic outcomes of PDAP. 展开更多
关键词 Diabetes mellitus Mortality Peritoneal dialysis Peritoneal dialysis-associated peritonitis Technical failure
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Application of nanoparticle tracking analysis for characterising the fate of engineered nanoparticles in sediment-water systems 认领 引用 被引量：5
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作者 Ping Luo Alejandro Roca +6 位作者 Karen Tiede Katie Privett Jiachao Jiang John Pinkstone Guibin Ma Jonathan Veinot Alisatair Boxall 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2018年第2期62-71,共10页
Novel applications of nanotechnology may lead to the release of engineered nanoparticles（ENPs）, which result in concerns over their potential environmental hazardous impact. It is essential for the research workers ... Novel applications of nanotechnology may lead to the release of engineered nanoparticles（ENPs）, which result in concerns over their potential environmental hazardous impact. It is essential for the research workers to be able to quantitatively characterise ENPs in the environment and subsequently to assist the risk assessment of the ENPs. This study hence explored the application of nanoparticle tracking system（NTA） to quantitatively describe the behaviour of the ENPs in natural sediment-water systems. The NTA allows the measurement of both particle number concentration（PNC） and particle size distribution（PSD） of the ENPs. The developed NTA method was applied to a range of gold and magnetite ENPs with a selection of surface properties. The results showed that the positively-charged ENPs interacted more strongly with the sediment than neutral and negatively-charged ENPs. It was also found that the citrate coated Au ENPs had a higher distribution percentage（53%） than 11-mercaptoundecanoic acid coated Au ENPs（20%） and citrate coated magnetite ENPs（21%）. The principles of the electrostatic interactions between hard（and soft） acids and bases（HSAB） are used to explain such behaviours; the hard base coating（i.e. citrate ions） will interact more strongly with hard acid（i.e. magnetite） than soft acid（i.e. gold）.The results indicate that NTA is a complementary method to existing approaches to characterise the fate and behaviour of ENPs in natural sediment. 展开更多
关键词 Quantitative characterisation Hard and soft acids and bases Fate of engineered nanoparticles Nanoparticle tracking system Particle number concentration Particle size distribution
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Genomic prediction of yield performance among single-cross maize hybrids using a partial diallel cross design 认领 引用 被引量：5
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作者 Ping Luo Houwen Wang +23 位作者 Zhiyong Ni Ruisi Yang Fei Wang Hongjun Yong Lin Zhang Zhiqiang Zhou Wei Song Mingshun Li Jie Yang Jianfeng Weng Zhaodong Meng Degui Zhang Jienan Han Yong Chen Runze Zhang Liwei Wang Meng Zhao Wenwei Gao Xiaoyu Chen Wenjie Li Zhuanfang Hao Junjie Fu Xuecai Zhang Xinhai Li 《The Crop Journal》 SCIE CSCD 2023年第6期1884-1892,共9页
Genomic prediction(GP)in plant breeding has the potential to predict and identify the best-performing hybrids based on the genotypes of their parental lines.In a GP experiment,34 elite inbred lines were selected to ma... Genomic prediction(GP)in plant breeding has the potential to predict and identify the best-performing hybrids based on the genotypes of their parental lines.In a GP experiment,34 elite inbred lines were selected to make 285 single-cross hybrids in a partial-diallel cross design.These lines represented a mini-core collection of Chinese maize germplasm and comprised 18 inbred lines from the Stiff Stalk heterotic group and 16 inbred lines from the Non-Stiff Stalk heterotic group.The parents were genotyped by sequencing and the 285 hybrids were phenotyped for nine yield and yield-related traits at two locations in the summer sowing area(SUS)and three locations in the spring sowing area(SPS)in the main maizeproducing regions of China.Multiple GP models were employed to assess the accuracy of trait prediction in the hybrids.By ten-fold cross-validation,the prediction accuracies of yield performance of the hybrids estimated by the genomic best linear unbiased prediction(GBLUP)model in SUS and SPS were 0.51 and 0.46,respectively.The prediction accuracies of the remaining yield-related traits estimated with GBLUP ranged from 0.49 to 0.86 and from 0.53 to 0.89 in SUS and SPS,respectively.When additive,dominance,epistasis effects,genotype-by-environment interaction,and multi-trait effects were incorporated into the prediction model,the prediction accuracy of hybrid yield performance was improved.The ratio of training to testing population and size of training population optimal for yield prediction were determined.Multiple prediction models can improve prediction accuracy in hybrid breeding. 展开更多
关键词 Maize Genomic prediction Prediction model Genetic effects Hybrid performance
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Quantification of changes in zero valent iron morphology using X-ray computed tomography 认领 引用 被引量：2
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作者 Ping Luo Elizabeth H.Bailey Sacha J.Mooney 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2013年第11期2344-2351,共8页
Morphological changes within the porous architecture of laboratory scale zero valent iron （ZVI） permeable reactive barriers （PRBs）, after exposure to different groundwater conditions, have been quantified experime... Morphological changes within the porous architecture of laboratory scale zero valent iron （ZVI） permeable reactive barriers （PRBs）, after exposure to different groundwater conditions, have been quantified experimentally for different ZVI/sand ratios （10%, 50% and 100%, W/W） with the aim of inferring porosity changes in field barriers. Column studies were conducted to simulate interaction with different water chemistries, a synthetic groundwater, acidic drainage and deionised （DI） water as control. Morphological changes, in terms of pore size and distribution, were measured using X-ray computed tomography （CT）. CT image analysis revealed significant morphological changes in columns treated with different water chemistries. For example, 100% ZVI （W/W） columns had a higher frequency of small pores （0.6 mm） was observed in ZVI grains reacted with typical groundwater, resulting in a porosity of 27%, compared to 32% when exposed to DI water. In comparison, ZVI grains treated with the acidic drainage had higher porosity （44%） and larger average pore size （2.8 mm）. 10% ZVI PRB barrier material had the highest mean porosity （56%） after exposure to any water chemistry whilst 100% ZVI （W/W） columns always had the lowest （34%） with the 50% ZVI （W/W） in between （40%）. These results agree with previously published PRB field data and simultaneously conducted geochemical monitoring and mass balance calculation, indicating that both the geochemical and hydraulic environment of the PRB play an important role in determining barrier lifespan. This study suggests that X-ray CT image analysis is a powerful tool for studying the detailed inter pores between ZVI grains within PRBs. 展开更多
关键词 porosity change X-ray computer tomography mass balance permeable reactive barrier zero valent iron acidic drainage typical groundwater pore-clogging
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Efficient Slew-Rate Enhanced Operational Transconductance Amplifier 认领 引用
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作者 Xiao-Peng Wan Fei-Xiang Zhang +2 位作者 Shao-Wei Zhen Ya-Juan He Ping Luo 《Journal of Electronic Science and Technology》 EI CAS CSCD 2015年第1期14-19,共6页
Today, along with the prevalent use of portable equipment, wireless, and other battery powered systems, the demand for amplifiers with a high gain-bandwidth product（GBW）, slew rate（SR）, and at the same time very l... Today, along with the prevalent use of portable equipment, wireless, and other battery powered systems, the demand for amplifiers with a high gain-bandwidth product（GBW）, slew rate（SR）, and at the same time very low static power dissipation is growing. In this work, an operational transconductance amplifier（OTA） with an enhanced SR is proposed. By inserting a sensing resistor in the input port of the current mirror in the OTA, the voltage drop across the resistor is converted into an output current containing a term in proportion to the square of the voltage, and then the SR of the proposed OTA is significantly enhanced and the current dissipation can be reduced. The proposed OTA is designed and simulated with a 0.5μm complementary metal oxide semiconductor（CMOS） process. The simulation results show that the SR is 4.54V/μs, increased by 8.25 times than that of the conventional design, while the current dissipation is only 87.3%. 展开更多
关键词 Efficient gain-bandwidth product operational transconductance amplifier slew rate
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Ultra-Low Power Pipeline Structure Exploiting Noncritical Stage with Circuit-Level Timing Speculation 认领 引用
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作者 Tao Luo Ya-Juan He +2 位作者 Ping Luo Yan-Ming He Feng Hu 《Journal of Electronic Science and Technology》 CAS 2013年第3期301-305,共5页
With the increase of the clock frequency and silicon integration, power aware computing has become a critical concern in the design of the embedded processor and system-on-chip （SoC）. Dynamic voltage scaling （DVS）... With the increase of the clock frequency and silicon integration, power aware computing has become a critical concern in the design of the embedded processor and system-on-chip （SoC）. Dynamic voltage scaling （DVS） is an effective method for low-power designs. However, traditional DVS methods have two deficiencies. First, they have a conservative safety margin which is not necessary for most of the time. Second, they are exclusively concerned with the critical stage and ignore the significant potential free slack time of the noncritical stage. These factors lead to a large amount of power waste. In this paper, a novel pipeline structure with ultra-low power consumption is proposed. It cuts off the safety margin and takes use of the noncritical stages at the same time. A prototype pipeline is designed in 0.13 μm technology and analyzed. The result shows that a large amount of energy can be saved by using this structure. Compared with the fixed voltage case, 50% of the energy can be saved, and with respect to the traditional adaptive voltage scaling design, 37.8% of the energy can be saved. 展开更多
关键词 Index Terms---Adaptive circuits dynamic voltagescaling exploiting noncritical stage ultra-low power.
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Characterization of Fundamental Logics for the Sub-Threshold Digital Design 认领 引用
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作者 Yan-Ming He Ya-Juan He +2 位作者 Yang-Ming Li Shao-Wei Zhen Ping Luo 《Journal of Electronic Science and Technology》 CAS 2013年第4期382-387,共6页
Digital circuits operating in the sub-threshold regime consume the least energy. The strict energy constraints are desired in the applications which work at the lowest possible supply voltage. On the other hand, the c... Digital circuits operating in the sub-threshold regime consume the least energy. The strict energy constraints are desired in the applications which work at the lowest possible supply voltage. On the other hand, the conventional design flow utilizes the technology library provided by the foundry with a fixed voltage boundary, which causes problems when the supply scales down to the sub-threshold regime. In this paper, we present a design methodology to characterize the existing cell library with Liberty NCX to facilitate the standard design flow. It is demonstrated in 0.13 μm complementary metal-oxide-semiconductor （CMOS） technology with the supply voltage of 300 mV. 展开更多
关键词 Characterization digital circuit lowpower sub-threshold voltage technology library.
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Construction and prokaryotic expression of the fusion protein Stx2B-IntiminC300 of EHEC O157: H7 and its immunoprophylactic potential 认领 引用 被引量：2
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作者 YONG YI Xu Hu MAO +9 位作者 WEN DE TONG YING MA MING ZEN YONG HONG ZHU QUAN MING ZOU XIA AI JIAN PING CHENG WEI JUN ZHANG JIANG GU PING LUO 《Journal of Microbiology and Immunology》 2006年第2期88-95,共8页
To construct and express the fusion protein Stx2B-IntiminC300 of EHEC O157 ： H7, and to further investigate its immunoprophylactic potential, the gene of Stx2B （stx2b） from EHEC O157：H7 chromosome was cloned into ... To construct and express the fusion protein Stx2B-IntiminC300 of EHEC O157 ： H7, and to further investigate its immunoprophylactic potential, the gene of Stx2B （stx2b） from EHEC O157：H7 chromosome was cloned into pMD18-T vector. Thereafter, the amplified gene was cloned into prokary- otic expression plasmid pET-28a （ ＋ ）-eaeC300, which was constructed previously. The recombinant pasmid pET-28a（ ＋ ）-stx2b-eaeC300 was transformed into E. coli BL21 （DE3）. After inducement, the protein Stx2B-IntiminC300 was successfully expressed and analyzed with sodium dodecyl sulfate polyacrylamide gel electrophoresis （SDS-PAGE）, Western blotting and N-terminal amino acid residual sequencing. To evaluate its immunoprophylactic potential, it was primarily purified by ion-exchange chromatography and injected into 30 BALB/c mice with AI（OH）3 in the subscapular region. Ten days after the last booster vaccination, 20 mice were attacked with EHEC O157：H7 lysate and the protective efficacy was observed. In the present study, the gene of Stx2B-intiminC300 was successfully cloned into pET-28a （ ＋ ） vector. The results of SDS-PAGE and Western blotting assay showed that the fusion protein was successfully expressed in the inclusion body form, accounting for 25 % of total expression products, and its molecular weight was about 43 kDa. The result of the N-terminal amino acid residual sequencing showed that it was identical to that of the molecular designed. The purity was about 75 % after primary purification. Animal tests revealed that the fusion protein Stx2B-intiminC300 has elicited high titer of protective antibody relatively. These results demonstrate that the fusion protein Stx2B-IntiminC300 is successfully expressed in prokaryotic expression system and shows certain immunoprophylactic potential. 展开更多
关键词 EHEC O157 ： H7 Intimin IntiminC300 Stx2B Vaccine Immunoprophylactic potential Enterohemorrhagic Escherichia coli （ EHEC ）
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Application of real-time shear wave elastography to Achilles tendon hardness evaluation in older adults 认领 引用 被引量：3
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作者 Xuan He Xin Wei +2 位作者 Jia Hou Wei Tan Ping Luo 《World Journal of Clinical Cases》 SCIE 2024年第26期5922-5929,共8页
BACKGROUND Real-time shear wave elastography(SWE)is a non-invasive imaging technique used to measure tissue stiffness by generating and tracking shear waves in real time.This advanced ultrasound-based method provides ... BACKGROUND Real-time shear wave elastography(SWE)is a non-invasive imaging technique used to measure tissue stiffness by generating and tracking shear waves in real time.This advanced ultrasound-based method provides quantitative information regarding tissue elasticity,offering valuable insights into the mechanical properties of biological tissues.However,the application of real-time SWE in the musculoskeletal system and sports medicine has not been extensively studied.AIM To explore the practical value of real-time SWE for assessing Achilles tendon hardness in older adults.METHODS A total of 60 participants were enrolled in the present study,and differences in the elastic moduli of the bilateral Achilles tendons were compared among the following categories:(1)Age:55-60,60-65,and 65-70-years-old;(2)Sex:Male and female;(3)Laterality:Left and right sides;(4)Tendon state:Relaxed and tense state;and(5)Tendon segment:Proximal,middle,and distal.RESULTS There were no significant differences in the elastic moduli of the bilateral Achilles tendons when comparing by age or sex(P>0.05).There were,however,significant differences when comparing by tendon side,state,or segment(P<0.05).CONCLUSION Real-time SWE plays a significant role compared to other examination methods in the evaluation of Achilles tendon hardness in older adults. 展开更多
关键词 Aged Achilles tendon Real-time Shear wave elastography Young’s modulus Muscle stiffness
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自然保护区生物标本资源共享子平台红外相机数据库建设进展 认领 引用 被引量：14
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作者 李佳 王秀磊 +9 位作者 杨明伟 陈大祥 王晓菊 罗平 刘芳 薛亚东 李广良 张于光 张宇 李迪强 《生物多样性》 CAS CSCD 北大核心 2020年第9期1081-1089,共9页
红外相机技术在野生动物调查研究中得到广泛应用,其发展和普及为中国自然保护地生物多样性保护带来了诸多机会。为进一步推广该技术在我国自然保护地野生动物监测中的应用,中国林业科学研究院森林生态环境与保护研究所在自然保护区生物... 红外相机技术在野生动物调查研究中得到广泛应用,其发展和普及为中国自然保护地生物多样性保护带来了诸多机会。为进一步推广该技术在我国自然保护地野生动物监测中的应用,中国林业科学研究院森林生态环境与保护研究所在自然保护区生物标本资源共享子平台增设野生动物红外相机数据库专栏,并通过门户网站"中国自然保护区生物标本资源共享平台"(http://gffzz11c3e935e38f46c1hcbqpvpq5kn606nuo.ffgz.tsg.suse.edu.cn/)对外发布,向公众开放,可以随时查阅、下载信息。本文重点介绍了该平台的野生动物红外相机数据库建设进展,包括所监测的自然保护区、监测方案、数据规范存储、标准化分析、成果介绍、工作计划等内容。2010–2019年间,该平台使用红外相机调查技术在全国13个不同类型的保护地开展兽类和鸟类资源调查,累计27.25万个有效工作日,共拍摄到8.41万张独立图像,经鉴定有80种野生兽类和200种野生鸟类,并利用这些数据对野生动物行为、稀有物种探测、人为干扰,以及气候变化影响等方面进行研究,取得了重要的阶段性成果。下一步,子平台牵头单位将筹建自然保护地红外相机数据共享平台,制定红外相机调查设计、监测技术、数据格式等统一标准化方案,逐步完善我国自然保护地野生动物红外相机监测网络。 展开更多
关键词 红外相机技术 野生动物监测 物种名录 自然保护地 数据共享
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