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Robotic duodenum-preserving pancreatic head resection in a 21-month-old infant with benign disease:Redefining the“minimum feasible age”for robotic surgery(with video) 认领 引用
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作者 Guo-Dong Zhao Yu-Hang Cheng +5 位作者 Xing-Ru Wang Jun Feng Jian-Yu Han Pan Gao Jia-Tong Xu Hong Qin 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第6期695-697,共3页
Herein,we describe a case of robotic duodenum-preserving pancreatic head resection(DPPHR)performed on a 21-monthold male infant(weight:13 kg;body mass index:18.87 kg/m2)with focal nesidioblastosis,expanding the sco... Herein,we describe a case of robotic duodenum-preserving pancreatic head resection(DPPHR)performed on a 21-monthold male infant(weight:13 kg;body mass index:18.87 kg/m2)with focal nesidioblastosis,expanding the scope of minimally invasive pediatric hepatobiliary surgery(Fig.1;Video S1).Preoperative positron emission tomography-computed tomography revealed a 23×13 mm neuroendocrine lesion in the pancreatic head,which caused refractory hypoglycemia and necessitated surgical intervention. 展开更多
关键词 minimally invasive surgery pediatric hepatobiliary surgery minimally invasive pediatric hepatobiliary surgery fig video neuroendocrine lesion focal nesidioblastosisexpanding refractory hypoglycemia surgical intervention robotic surgery
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Proposed Nanoscale Spin Field-Effect Transistors with 2D Ferroelectric Rashba Semiconductors 认领 引用
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作者 Jing Chen Mengshuo Kang +5 位作者 Qiwei Hu Pan Gao Tongwei Li Liangyu Wang Weiwei Ju Wei Hu 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2026年第3期377-389,I0049-I0055,共13页
The spin field-effect transistor(SFET)based on ferroelectric Rashba semiconductor(FRS)has a shorter channel length than ordinary transistors,making it an important type of future transistor.Through high-throughput inv... The spin field-effect transistor(SFET)based on ferroelectric Rashba semiconductor(FRS)has a shorter channel length than ordinary transistors,making it an important type of future transistor.Through high-throughput inverse design,AlBi and SiPb monolayers are considered to be very promising FRSs due to their prominent Rashba effect,the thinnest atomic structure,and surmountable energy barriers.Herein,we employ first-principles calculations to systematically investigate the modulation of Rashba effect,electric field response,and ferroelectricity in AlBi and SiPb monolayers.The large Rashba coefficients of 2.717 and 2.606 eV·Åare obtained for AlBi and SiPb monolayers,while they can be efficiently modulated by the external electric field and strain engineering.The electric field response of AlBi oscillates around 0.5 e·Å2and that of SiPb can reach 0.78 e·Å2,which can fully meet the requirements of practical applications.Furthermore,as typical two-dimensional ferroelectric materials,the coupling effect between ferroelectric polarization and spin polarization is also explored.Based on these investigations,we design two types of SFET with AlBi or SiPb monolayer as the channel.The SFET designed solely based on the electric field response without considering the ferroelectricity,has a channel length ranging from 70 nm to 100 nm.The SFET designed based on the ferroelectricity can reduce the channel length to below 2 nm,which is quite below the tolerance of coherent transport in semiconductors.Thus,two-dimensional(2D)FRS can be considered as a promising candidate material for the next generation of SFETs. 展开更多
关键词 Rashba effect Ferroelectricity Spin field-effect transistor Electric field re-sponse AlBi and SiPb monolayers
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A novel thermometric performance of Dy3+ doped phosphor:Fluorescence lifetime of grain boundary-doped MgAlON:Dy3+ transparent ceramics 认领 引用
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作者 Zhengyang Jing Bowen Chen +5 位作者 Hao Wang Pan Gao Guangsheng Tu Bingtian Tu Weimin Wang Zhengyi Fu 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第1期120-128,共9页
The e nergy transfer(ET) between f-f transition is achieved by rare earth ions(RE3+) doped grain boundaries of transpare nt ceramics,which e nhances the fluorescence thermometry performance and enables multiple flu... The e nergy transfer(ET) between f-f transition is achieved by rare earth ions(RE3+) doped grain boundaries of transpare nt ceramics,which e nhances the fluorescence thermometry performance and enables multiple fluorescence thermometry modes of transparent ceramics.In this work,MgAlON:Dy3+transparent ceramics were prepared and segregation of Dy3+ in grain boundaries was realized.With excellent absolute and relative se nsitivities(2.447 μs/K and 2.09%/K),the fluorescence lifetime(FL)signals of MgAlON:Dy3+ excee ds most of RE3+ doped phosphors.The ET between closely segregated Dy3+in grain boundaries modifies the distribution of electron on 4I15/2 level,and induces temperaturedependent FL to the phosphors.This work reveals the influence of grain boundary segregation on ET between Dy3+ for improving the fluorescence thermometry performance of phosphors. 展开更多
关键词 Energy transfer Fluorescence lifetime Fluorescence thermometry Grain boundary MgAION:Dy3+ Rare earths
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Recent advances of heterogeneous manganese catalysis in organic synthesis 认领 引用
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作者 Tianyi Zhou Heng Yang +2 位作者 Guangbin Zhou Feng Chen Pan Gao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期156-183,共28页
In recent years,heterogeneous manganese catalysis has emerged as a significant area of research in catalytic chemistry,leveraging manganese-based materials to facilitate a wide range of chemical transformations.This r... In recent years,heterogeneous manganese catalysis has emerged as a significant area of research in catalytic chemistry,leveraging manganese-based materials to facilitate a wide range of chemical transformations.This review explores the fundamental principles,recent advances,applications,and prospects of heterogeneous manganese catalysis in organic synthesis.These catalysts are widely employed in C-C bond formation,C-N bond formation,C-O bond formation,oxidation.Despite this,manganese catalysts have not received as much attention as other metals,such as iron and cobalt,often resulting in their excellent catalytic activity being overlooked.This review focuses on the mechanisms and capabilities of heterogeneous manganese catalysts in various aspects of organic synthesis,highlighting the latest research advancements. 展开更多
关键词 Heterogeneous catalysis Manganese Coupling reactions Oxidation
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One-dimensional(C12H12N)3Cu3I6for high-performance direct X-ray detection 认领 引用
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作者 Pan Gao Qingzheng Kong +8 位作者 Ying Sun Qian Ma Qi Wang Zeyu Guo Ledi Li Bingbing Li Jingwei Xu Xiaomei Jiang Zhaolai Chen 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2026年第1期61-67,共7页
X-ray detectors,as crucial elements in medical imaging and industrial fields,can be categorized into direct and indirect types.Direct detectors,which directly convert X-ray photons into electrical signals,exhibit high... X-ray detectors,as crucial elements in medical imaging and industrial fields,can be categorized into direct and indirect types.Direct detectors,which directly convert X-ray photons into electrical signals,exhibit high sensitivity and low detection limits,enabling the capture of high-resolution images and reducing radiation exposure to patients.Organic copper halides,recognized as potential active materials for X-ray detection,have been widely explored in the indirect scintillation field but remain under-explored in direct X-ray detector applications.In this work,(C12H12N)3Cu3I6is demonstrated as an efficient semiconductor for direct X-ray detection with excellent stability.A lateral-structured X-ray detector was fabricated with gold electrodes,which exhibits a maximum sensitivity of 1464.14μC·Gy-1·cm-2,a lowest detection limit of 19.8 nGy·s-1,a high on-off ratio of 2140,and an excellent operational stability of retaining 96%performance after 600 s continuous X-ray radiation.Furthermore,the detector successfully imaged a 0.1 mm“F”-shaped lead sheet,validating its capacity for X-ray imaging.This study highlights the potential of(C12H12N)3Cu3I6as a promising semiconductor for high-performance direct X-ray detection,expanding the application scope of organic copper halides in this critical field. 展开更多
关键词 Organic copper halides One-dimensional structure X-ray detection X-ray imaging
Research on the Impact of Different Lymph Node Dissection Scopes on Postoperative Recurrence and Survival Rates in Patients with Early Gastric Cancer 认领 引用
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作者 Zhijun Mao Yingdi Wei +2 位作者 Ganjie Yang Pan Gao Tong Hui 《Proceedings of Anticancer Research》 2026年第1期130-137,共8页
Early-stage gastric cancer;Extent of lymph node dissection;D1 dissection;D2 dissection;Recurrence rate;Survival rateObjective:To investigate the impact of different lymph node dissection scopes on postoperative recurr... Early-stage gastric cancer;Extent of lymph node dissection;D1 dissection;D2 dissection;Recurrence rate;Survival rateObjective:To investigate the impact of different lymph node dissection scopes on postoperative recurrence and survival rates in patients with early gastric cancer,providing evidence-based support for optimizing clinical surgical plans.Methods:A retrospective analysis was conducted on the clinical data of 100 patients with early gastric cancer who underwent surgical treatment at our hospital from October 2021 to October 2023.Patients were divided into Group D1(n=50)and Group D2(n=50)based on the extent of lymph node dissection.Group D1 underwent limited lymph node dissection(dissection of the first station of lymph nodes around the stomach),while Group D2 underwent standard lymph node dissection(dissection of the first and second stations of lymph nodes around the stomach).Surgical-related indicators,the incidence of postoperative complications,the 2-year recurrence rate,and the 2-year survival rate were compared between the two groups of patients.Results:The operative time,intraoperative blood loss,postoperative hospital stay,and the number of lymph nodes dissected were significantly higher in the D2 group than in the D1 group(all P<0.001).The overall incidence of postoperative complications was higher in the D1 group than in the D2 group,but the difference was not statistically significant(χ2=0.884,P=0.766).After a 2-year follow-up,the recurrence rate was significantly higher in the D1 group than in the D2 group(χ2=4.000,P=0.046).The 2-year survival rate was significantly lower in the D1 group than in the D2 group(χ2=5.005,P=0.025).A total of 100 patients with early-stage gastric cancer were grouped according to the depth of invasion,degree of differentiation,and lymph node metastasis status,and the recurrence rates of different subgroups were compared.The results showed that the recurrence rate was higher in patients with T1b stage than in those with T1a stage(χ2=5.005,P=0.025),higher in poorly differentiated patients than in moderately and well-differentiated patients(χ2=4.155,P=0.042),and higher in patients with lymph node metastasis than in those without lymph node metastasis(χ2=4.512,P=0.034).Conclusion:Compared with D1 limited lymph node dissection,D2 standard lymph node dissection can significantly reduce the postoperative recurrence rate and improve the 2-year survival rate in patients with early-stage gastric cancer without significantly increasing the risk of postoperative complications.Although the surgical trauma is slightly greater,the overall prognosis is better,making it a preferred surgical treatment option for patients with early-stage gastric cancer. 展开更多
关键词 Early-stage gastric cancer Extent of lymph node dissection D1 dissection D2 dissection Recurrence rate Survival rate
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Mechanism of Action and Clinical Intervention Potential of Intestinal Dysbiosis in the Occurrence and Development of Gastric Cancer 认领 引用
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作者 Zhijun Mao Yingdi Wei +2 位作者 Ganjie Yang Pan Gao Tong Hui 《Proceedings of Anticancer Research》 2026年第2期17-24,共8页
Objective:To explore the mechanism of action of intestinal dysbiosis in the occurrence and development of gastric cancer and analyze its potential for clinical intervention.Methods:Eighty patients with gastric cancer ... Objective:To explore the mechanism of action of intestinal dysbiosis in the occurrence and development of gastric cancer and analyze its potential for clinical intervention.Methods:Eighty patients with gastric cancer admitted to our hospital from January 2024 to November 2025 were selected as the study group,and another 40 healthy individuals undergoing physical examinations during the same period were selected as the control group.The fecal bacterial and fungal culture method was employed to quantify the primary intestinal flora,including Bifidobacteria,Lactobacilli,Escherichia coli,Enterococci,and Bacteroides,in both groups of study subjects,and the bacilli-to-cocci ratio was calculated.Additionally,serum levels of inflammatory cytokines(IL-6,TNF-α)and immune-related factors(PD-L1,IL-10)were measured.Gastric cancer patients were randomly divided into an intervention group(40 cases)and an observation group(40 cases).The observation group received a conventional chemotherapy regimen,while the intervention group received probiotic intervention in addition to chemotherapy.The incidence of chemotherapy-related adverse reactions and changes in intestinal flora were compared between the two groups.Results:The quantities of Bifidobacteria and Lactobacilli,as well as the bacilli-to-cocci ratio,were significantly lower in the study group compared to the control group,whereas the quantities of Escherichia coli and Enterococci were significantly higher,with all differences being statistically significant(all P<0.001).Serum levels of IL-6,TNF-α,PD-L1,and IL-10 were significantly higher in the study group than in the control group(P<0.01).After intervention,the quantities of Bifidobacteria and Lactobacilli,as well as the bacilli-to-cocci ratio,were significantly lower in the observation group than before intervention,while the quantities of Escherichia coli and Enterococci were significantly higher(all P<0.01).Serum levels of IL-6,TNF-α,PD-L1,and IL-10 in the study group remained significantly higher than those in the control group(P<0.01).In the intervention group,the quantities of Bifidobacteria and Lactobacilli,as well as the bacilli-to-cocci ratio,were significantly higher after intervention than before,while the quantities of Escherichia coli and Enterococci were significantly lower(all P<0.001).Furthermore,after intervention,the quantities of Bifidobacteria and Lactobacilli,as well as the bacilli-to-cocci ratio,were significantly higher in the intervention group than in the observation group,while the quantities of Escherichia coli and Enterococci were significantly lower(all P<0.01).The incidence of adverse reactions was significantly lower in the intervention group than in the observation group(P<0.001).Conclusion:Dysbiosis of intestinal flora may promote the occurrence and development of gastric cancer through mechanisms such as inducing chronic inflammation and inhibiting anti-tumor immunity;probiotic intervention can effectively regulate the balance of intestinal flora in gastric cancer patients,reduce adverse reactions to chemotherapy,and hold significant potential for clinical intervention. 展开更多
关键词 Dysbiosis of intestinal flora Gastric cancer Mechanism of action Inflammatory response Immunosuppression Probiotics
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Practical Exploration of the Stratified Teaching Model in Multidisciplinary Team(MDT)Teaching for Gastric Cancer 认领 引用
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作者 Zhijun Mao Yingdi Wei +2 位作者 Ganjie Yang Pan Gao Yuming Zhang 《Journal of Contemporary Educational Research》 2026年第2期96-102,共7页
Objective:To explore the application effect of the stratified teaching model in multidisciplinary team(MDT)teaching for gastric cancer,providing practical evidence for improving the quality of medical talent training ... Objective:To explore the application effect of the stratified teaching model in multidisciplinary team(MDT)teaching for gastric cancer,providing practical evidence for improving the quality of medical talent training in gastric cancer MDT diagnosis and treatment capabilities.Methods:Sixty learners who participated in gastric cancer MDT teaching at our hospital from July 2024 to July 2025 were selected as the research subjects and randomly divided into an observation group(n=30)and a control group(n=30)using a random number table method.The control group adopted the traditional“one-size-fits-all”teaching model,while the observation group employed a stratified teaching model.Students in the observation group were divided into basic,intermediate,and advanced levels based on their foundational knowledge and learning abilities,with differentiated teaching objectives,content,and evaluation systems implemented accordingly.The theoretical assessment scores,clinical skill operation scores,MDT case discussion ability ratings,and teaching satisfaction of students in both groups were compared after instruction.Results:After the teaching period,students in the observation group scored significantly higher than those in the control group in theoretical assessments,clinical skill operations,and MDT case discussion ability(P<0.001).Teaching satisfaction was also significantly higher in the observation group compared to the control group(P<0.05).Within the observation group,advanced-level students scored significantly higher than intermediate-and basic-level students in theoretical assessments,clinical skill operations,and MDT case discussion ability,while intermediate-level students outperformed basic-level students in all areas(all P<0.001).Conclusion:The stratified teaching model effectively enhances the quality of MDT teaching for gastric cancer,improving students’theoretical knowledge,clinical skills,and MDT case discussion abilities,as well as increasing teaching satisfaction.It is worthy of promotion and application in medical education. 展开更多
关键词 Stratified teaching Gastric cancer Multidisciplinary team MDT teaching Clinical teaching
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知识图谱驱动的程序与算法类课程教学体系构建与实践 认领 引用
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作者 高攀 李志刚 郑瑶 《计算机教育》 2026年第7期197-203,共7页
针对程序与算法类课程教学中存在的知识碎片化、关联性弱、个性化反馈不足等问题,提出知识图谱驱动的“点-线-面-智”四层递进式教学体系构建思路,以程序设计基础和数据结构与算法课程为例,介绍知识图谱驱动的程序与算法类课程教学体系... 针对程序与算法类课程教学中存在的知识碎片化、关联性弱、个性化反馈不足等问题,提出知识图谱驱动的“点-线-面-智”四层递进式教学体系构建思路,以程序设计基础和数据结构与算法课程为例,介绍知识图谱驱动的程序与算法类课程教学体系构建与教学实践过程,最后说明教学实践效果。 展开更多
关键词 知识图谱 程序与算法类课程 AI助手 “点-线-面-智”
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Unveiling the promotion role of ZnO on Zn-Al spinel oxide for CO2hydrogenation 认领 引用 被引量:3
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作者 Tongyao Wang Xinlong Yao +3 位作者 Lixin Liang Hongyu Chen Pan Gao Guangjin Hou 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第1期18-25,共8页
The Zn-Al spinel oxide stands out as one of the most active catalysts for high-temperature methanol synthesis from CO2hydrogenation.However,the structure–activity relationship of the reaction remains poorly unders... The Zn-Al spinel oxide stands out as one of the most active catalysts for high-temperature methanol synthesis from CO2hydrogenation.However,the structure–activity relationship of the reaction remains poorly understood due to challenges in atomic-level structural characterizations and analysis of reaction intermediates.In this study,we prepared two Zn-Al spinel oxide catalysts via coprecipitation(ZnAl-C)and hydrothermal(ZnAl-H)methods,and conducted a comparative investigation in the CO2hydrogenation reaction.Surprisingly,under similar conditions,ZnAl-C exhibited significantly higher selectivity towards methanol and DME compared to ZnAl-H.Comprehensive characterizations using X-ray diffraction(XRD),Raman spectroscopy and electron paramagnetic resonance(EPR)unveiled that ZnAl-C catalyst had abundant ZnO species on its surface,and the interaction between the ZnO species and its ZnAl spinel oxide matrix led to the formation of oxygen vacancies,which are crucial for CO2adsorption and activation.Additionally,state-of-the-art solid-state nuclear magnetic resonance(NMR)techniques,including ex-situ and in-situ NMR analyses,confirmed that the surface ZnO facilitates the formation of unique highly reactive interfacial formate species,which was readily hydrogenated to methanol and DME.These insights elucidate the promotion effects of ZnO on the ZnAl spinel oxide in regulating active sites and reactive intermediates for CO2-to-methanol hydrogenation reaction,which is further evidenced by the significant enhancement in methanol and DME selectivity observed upon loading ZnO onto the ZnAl-H catalyst.These molecular-level mechanism understandings reinforce the idea of optimizing the ZnO-ZnAl interface through tailored synthesis methods to achieve activity-selectivity balance. 展开更多
关键词 CO2hydrogenation Spinel oxide Zno Solid-state NMR
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Surface gallium hydride on Ga2O3 polymorphs:A comparative solid-state NMR study 认领 引用
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作者 Honglin Gao Chunlin Yuan +3 位作者 Hongyu Chen Aiyi Dong Pan Gao Guangjin Hou 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2025年第4期56-63,共8页
As a highly reactive reaction intermediate,surface gallium hydride(Ga–H)has garnered significant attention due to its critical role in various catalytic reactions.However,the detailed experimental characterization of... As a highly reactive reaction intermediate,surface gallium hydride(Ga–H)has garnered significant attention due to its critical role in various catalytic reactions.However,the detailed experimental characterization of this unique species remains challenging.Recently,we have demonstrated that solid-state NMR can be an effective tool for studying surface Ga–H.In this work,we report a comparative solid-state NMR study on H2 activation over different Ga2O3 polymorphs,specificallyα-,β-andγ-Ga2O3.1H solid-state NMR enabled the identification of Ga–H species formed on all the three samples following high-temperature H2 treatment.The characteristic 1H NMR signals of Ga–H species are resolved using J-coupling-based double-resonance NMR methods,revealing highly similar lineshapes of Ga–H for all the Ga2O3 samples.This suggests potentially similar surface Ga–H configurations among different Ga2O3 polymorphs.In addition,the local hydrogen environments on the oxide surfaces are further explored using two-dimensional(2D)1H–1H homonuclear correlation spectra,revealing multiple spatially proximate Ga–H and Ga–H/–OH pairs on different Ga2O3 polymorphs.These findings provide insights into the potential mechanism of H2 dissociation.Overall,this work offers new perspectives on the local structure of surface Ga–H on Ga2O3,and the analytical approach presented here can be further extended to the study of other Ga-based catalysts and other metal hydride species. 展开更多
关键词 Gallium hydride Solid-state NMR J-coupling Surface configuration Dissociation mechanism
锰耐受性种子内生菌筛选及其促进锰胁迫下种子萌发与幼苗生长的研究 认领 引用
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作者 余子欣 沈为正 +2 位作者 潘高 王雯颖 刘文胜 《草业学报》 CSCD 北大核心 2026年第6期145-154,共10页
本研究以前期从湘潭锰矿植物种子获得的4种优势可培养种子内生真菌及大叶胡枝子、五节芒、青葙和藜这4种不同生活型的植物种子为材料,开展真菌锰耐受性试验以及接种内生菌对锰胁迫下种子发芽与幼苗生长影响的试验。研究结果显示,4种内... 本研究以前期从湘潭锰矿植物种子获得的4种优势可培养种子内生真菌及大叶胡枝子、五节芒、青葙和藜这4种不同生活型的植物种子为材料,开展真菌锰耐受性试验以及接种内生菌对锰胁迫下种子发芽与幼苗生长影响的试验。研究结果显示,4种内生真菌相比较,链格孢霉在高锰胁迫下的菌落直径、生物量变化最小。该菌的最小抑菌浓度为50 mmol·L-1,Mn2+吸附率达75.6%,高于其他3株真菌,这说明链格孢霉锰耐受性最强。接种链格孢霉提高了锰胁迫下大叶胡枝子、五节芒、青葙和藜的种子发芽率与发芽势,促进了幼苗生长。高Mn2+浓度(20 mmol·L-1)时,大叶胡枝子、五节芒、青葙、藜的接菌组发芽率分别较非接菌组提高4.9%、12.9%、88.9%、93.3%,总生物量则分别较非接菌组提高4.0%、117.1%、31.5%、35.7%。这说明链格孢霉对胁迫下种子发芽与幼苗生长的促进作用具有广谱性。 展开更多
关键词 锰胁迫 种子内生菌 种子萌发 幼苗生长 耐受性
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Precursor and dual-template assisted synthesis of highly acidic SAPO-17 molecular sieve:Excellent NH3-SCR activity of Cu-exchanged forms 认领 引用
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作者 Ye Wang Pan Gao +10 位作者 Dan Zhao Tongrui Liu Sitong Zhou Miao Yang Shiping Liu Bing Li Yida Zhou Wenhao Cui Guangjin Hou Peng Tian Zhongmin Liu 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第11期279-291,共13页
Silicoaluminophosphate(SAPO)molecular sieves possess diverse architectures and exceptional high-temperature hydrothermal stability,rendering them important acid catalysts.However,enhancing acid concentration of certai... Silicoaluminophosphate(SAPO)molecular sieves possess diverse architectures and exceptional high-temperature hydrothermal stability,rendering them important acid catalysts.However,enhancing acid concentration of certain SAPO materials remains challenging,which limits their catalytic applications.Here,we report the synthesis of a series of SAPO materials using a developed SAPO precursor plus dual template(SPDT)strategy.A variety of SAPO materials characterized by high silica content and enhanced acidity,such as SAPO-34/56 intergrowths,SAPO-56,and SAPO-17,have been synthesized and thoroughly characterized using various techniques including integrated differential phase-contrast scanning transmission electron microscopy,two-dimensional solid-state nuclear magnetic resonance spectroscopy,and continuous rotation electron diffraction.The use of silica-enriched SAPO precursor combined with the flexible selection of the second template enables the crystalline phase regulation and improves the Si atoms incorporation into the framework.Notably,the synthesized SAPO-17 with abundant Si(4Al)species and unprecedentedly high acid density exhibits exceptional DeNOxactivity after Cu loading,with NOxconversion exceeding 90%at 175–700℃.This outstanding performance can be attributed to the unique ERI structure and the increased acidity of SAPO-17.This work not only presents an effective method for synthesizing SAPO molecular sieves with enhanced acidity but also offers a new perspective for expanding the active temperature range of the ammonia selective catalytic reduction reaction. 展开更多
关键词 SAPO molecular sieve Ammonia selective catalytic reduction Ultra-wide temperature window Si distribution Acidity
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丙泊酚对妇科恶性肿瘤切除术后临床结局的影响及其机制 认领 引用 被引量:2
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作者 潘高 魏义勇 +1 位作者 张娟 王海英 《中国临床研究》 CAS 2025年第6期827-830,共4页
妇科恶性肿瘤发病率长期居高不下,目前的治疗手段主要以全身麻醉下的肿瘤切除为主。丙泊酚被广泛用于全身麻醉的诱导和维持。丙泊酚对妇科恶性肿瘤患者预后具有重要的影响,然而其具体机制不清楚。目前的研究表明,丙泊酚可通过调控细胞... 妇科恶性肿瘤发病率长期居高不下,目前的治疗手段主要以全身麻醉下的肿瘤切除为主。丙泊酚被广泛用于全身麻醉的诱导和维持。丙泊酚对妇科恶性肿瘤患者预后具有重要的影响,然而其具体机制不清楚。目前的研究表明,丙泊酚可通过调控细胞结构、自噬、化疗药物的敏感性,以及通过微小RNA(miRNA)、环状RNA(circRNA)、长链非编码RNA(lncRNA)和Yes相关蛋白(YAP)通路及人体自身免疫系统等途径改善妇科恶性肿瘤预后的作用。因此,本文对丙泊酚对妇科恶性肿瘤患者预后的影响及其机制,包括丙泊酚对细胞结构、自噬、化疗药物的敏感性调控,以及经miRNA、circRNA、lncRNA和YAP通路等发挥作用的机制作一综述。 展开更多
关键词 丙泊酚 妇科肿瘤 细胞自噬 化疗药物 微小RNA 环状RNA 长链非编码RNA
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Recent advances on surface metal hydrides studied by solid-state nuclear magnetic resonance spectroscopy 认领 引用 被引量:1
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作者 Pan Gao Guangjin Hou 《Magnetic Resonance Letters》 2023年第1期31-42,I0003,共12页
Metal hydrides (MeH) on solid surfaces, i.e., surface MeH, are ubiquitous but criticalspecies in heterogeneous catalysis, and their intermediate roles have been proposed innumerous reactions such as (de)hydrogenation ... Metal hydrides (MeH) on solid surfaces, i.e., surface MeH, are ubiquitous but criticalspecies in heterogeneous catalysis, and their intermediate roles have been proposed innumerous reactions such as (de)hydrogenation and alkanes activation, etc., however, thedetailed spectroscopic characterizations remain challenging. Solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become a powerful tool in surface studies, asit provides access to local structural characterizations at atomic level from multipleviews, with comprehensive information on chemical bonding and spatial structures. Inthis review, we summarized and discussed the latest research developments on thesuccessful application of ssNMR to characterize surface MeH species on solid catalystsincluding supported single-site heterogeneous catalysts, bulk metal oxides and metalmodified zeolites. We also discussed the opportunities and challenges in this field, aswell as the potential application/development of state-of-the-art ssNMR technologies toenable further exploration of metal hydrides in heterogeneous catalysis. 展开更多
关键词 Metal hydrides Surface chemistry Intermediate Solid-state NMR Heterogeneous catalysis
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A Novel Method for Mitochondrial Membrane Potential Detection in Heart Tissue Following Ischemia-reperfusion in Mice 认领 引用
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作者 Chao YIN Chen-xing HUANG +8 位作者 Le PAN Ke-jia JIN Ying WANG Meng-ying CAO Hong LIN Pan GAO Na LI Hui GONG Yun-zeng ZOU 《Current Medical Science》 SCIE CAS 2024年第6期1091-1096,共6页
Objective:Myocardial ischemia-reperfusion(I/R)injury is associated with a significant reduction in the mitochondrial membrane potential(MMP,ΔΨm).Fluorescence-based assays are effective for labelling active mitochond... Objective:Myocardial ischemia-reperfusion(I/R)injury is associated with a significant reduction in the mitochondrial membrane potential(MMP,ΔΨm).Fluorescence-based assays are effective for labelling active mitochondria in living cells;their application in heart tissue,however,represents a challenge because of a low yield of viable cardiomyocytes after cardiac perfusion.This study aimed to examine a novel method for detecting the changes in the MMP of mouse heart tissue following I/R injury.Methods:The I/R model was established,which was characterized by distinct ischemic area and apoptosis in heart tissue.The MMP was detected via a confocal microscope after the ascending aorta was clamped and the mitochondrial probe solution(containing Mito-Tracker Deep Red FM)was perfused from the apex via a peristaltic pump.Results:This method enabled the distribution of the probe solution throughout the cardiac tissue via the coronary circulation.Fluorescence detection revealed that the MMP was profoundly reduced in both ischemic area and border area following I/R when compared with that in the sham group.There was no obvious difference in the MMP of the remote area between the I/R group and the sham group.Conclusion:This study presents a novel method for detecting the MMP in heart tissue,and this method will facilitate the evaluation of changes in the MMP in different regions following I/R. 展开更多
关键词 mitochondrial membrane potential heart tissue ischaemia-reperfusion mitochondrial function
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DNP NMR reveals the hidden surface C–C bond growth mechanism over ZnAlOx during syngas conversion 认领 引用
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作者 Pan Gao Dong Xiao +5 位作者 Zhenchao Zhao Subhradip Paul Frédéric Blanc Xiuwen Han Guangjin Hou Xinhe Bao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第4期640-644,共5页
Direct catalytic transformation of syngas(CO/H2) into high value-added hydrocarbons has been one of the most attractive,yet challenging issues in C1 chemistry. In recent years, the concept of oxide-zeolite(OXZEO) b... Direct catalytic transformation of syngas(CO/H2) into high value-added hydrocarbons has been one of the most attractive,yet challenging issues in C1 chemistry. In recent years, the concept of oxide-zeolite(OXZEO) bifunctional catalysis has emerged and spurred renewed enthusiasm in this field [1,2]. This method describes the use of selected oxide-zeolite-based composite catalysts for the direct syngas-to-hydrocarbons conversion. 展开更多
关键词 zeolite hydrocarbons syngas
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Association between polymorphisms in the human serotonin transporter gene and lifelong premature ejaculation in the Han population 认领 引用
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作者 Dang-Wei Peng Jing-Jing Gao +9 位作者 Yuan-Yuan Huang Dong-Dong Tang Pan Gao Chao Li Wei-Qun Liu Xian-Ming Dou Jun Mao Yao Zhang Hao Geng Xian-Sheng Zhang 《Asian Journal of Andrology》 SCIE CAS CSCD 2018年第1期103-104,共2页
Dear Editor, Lifelong premature ejaculation (LPE) is a type of sexual dysfunction in males and has three characteristics: (1) an intravaginal ejaculatory latency time (IELT) of 〈 1 rain; (2) insufficient con... Dear Editor, Lifelong premature ejaculation (LPE) is a type of sexual dysfunction in males and has three characteristics: (1) an intravaginal ejaculatory latency time (IELT) of 〈 1 rain; (2) insufficient control over delaying ejaculation; and (3) negative personal consequences, such as distress, frustration, and/or the avoidance of sexual intimacy2 Its etiologies involve the 5-hydroxytryptamine (5-HT) system. The use of 5-HT transporter (5-HTT) blockers (e.g., selective serotonin reuptake inhibitors, SSRIs) was found to prevent the reuptake of 5-HT from the synaptic cleft into the presynaptic serotonergic neurons, which leads to increased extracellular 5-HT levels, thereby delaving ejaculation. 展开更多
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Association between serotonin transporter 5-HTTLPR and STin2 VNTR polymorphisms and anejaculation: a preliminary report 认领 引用
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作者 Yuan-Yuan Huang Xian-Sheng Zhang +2 位作者 Jing-Jing Gao Pan Gao Chao-Zhao Liang 《Asian Journal of Andrology》 SCIE CAS CSCD 2017年第6期719-720,共2页
Dear Editor, Anejaculation is a rare ejaculatory disorder in men (1%-4% of sexually active men) that can cause male factor infertility.1 Although these patients are generally healthy individuals that may have erecti... Dear Editor, Anejaculation is a rare ejaculatory disorder in men (1%-4% of sexually active men) that can cause male factor infertility.1 Although these patients are generally healthy individuals that may have erections and nocturnal emissions, they cannot ejaculate. As we all know, there is evidence that the etiology of ejaculatory dysfunction is partially genetic, especially related to serotonergic genes.2 Here, we report two polymorphic regions in serotonin transporter (5-HTT) gene for the first time in three Chinese males with anejaculation. 展开更多
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Cultivating global health professionals: evaluation of a training course to develop international consulting service competence in China 认领 引用 被引量:1
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作者 Pan Gao Li Guan +7 位作者 Yisi Liu Feifei Liu Wenyuan Yu Xiangyu Li Suyang Liu Yuanan Lu Hao Li Hao Xiang 《Global Health Journal》 2020年第2期51-56,共6页
Background:China’s accelerating development and increasingly important role in global health engagement create a great demand for global health professionals including international consulting experts.This study repo... Background:China’s accelerating development and increasingly important role in global health engagement create a great demand for global health professionals including international consulting experts.This study reported the detailed development and evaluation of an international consulting training for global health workforce.Methods:Based on Kirkpatrick’s model,a mixed-methods approach was used to evaluate the effectiveness of the training.Quantitative and qualitative data on participants’reaction,learning,and application of the learned knowledge and skills were collected by a training evaluation survey at the ending of training and a follow-up interview in three months after the training.Results:Thirty-six participants attended the training and 34 of them completed quantitative investigation.The training satisfaction evaluations were positive,for which participants rated the training program highly and over 90%of them agreed with the usefulness of the training.About knowledge and skills change,participants showed improved consulting knowledge and skills from pre-to post-training(P<0.001).A total of 23 participants accepted follow-up interview,and most participants applied knowledge and skills learned from the training in their daily work or study.However,only 30.4%of participants applied their learning in the consulting program.The largest barrier of application was the lack of consulting opportunities.In addition,almost all the participants reported that they would be glad to attend more training courses in the future.Conclusion:The international consulting training program was well-received,and was feasible to improve the consulting service competence of global health professionals.According to participants’feedback,it is essential to develop and expand consulting training in the field of global health. 展开更多
关键词 Training evaluation Satisfaction Kirkpatrick’s model Global health International consulting service
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