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Pathophysiology of ocular manifestations in Wilson’s disease and its management 认领 引用
1
作者 Manpreet Kaur Shweta Walia +7 位作者 Arvind Kumar Morya Puja Hingorani Bang Sarita Aggarwal Parul Chawla Gupta Rutuja Nagare Hemlata Udenia Srishti Khullar Rannusha Morya 《World Journal of Clinical Cases》 2026年第14期1-13,共13页
Wilson’s disease(WD)is an inherited disorder affecting copper metabolism.Ocular manifestations,particularly Kayser-Fleischer rings and sunflower cataracts,are key diagnostic indicators.This article provides an overvi... Wilson’s disease(WD)is an inherited disorder affecting copper metabolism.Ocular manifestations,particularly Kayser-Fleischer rings and sunflower cataracts,are key diagnostic indicators.This article provides an overview of the pathophysiology of WD and describes current imaging techniques used for the detection and monitoring of the disease:Slit lamp examination,anterior segment optical coherence tomography,and in vivo confocal microscopy.It also touches on other rare ocular manifestations,which include retinal abnormalities,optic neuropathy,and oculomotor abnormalities,which are an extension of systemic symptoms.With the advent of new imaging techniques,the amount of corneal copper deposition can be quantified.Ocular manifestations are used to assess neurological symptoms and the extent of adherence to treatment.Patients suffering from WD are recommended to undergo comprehensive eye exams regularly.This article is a comprehensive literature review up to 2025 and provides an overview of WD for a multidisciplinary team of healthcare workers. 展开更多
关键词 Wilson disease Ocular manifestation Kayser-Fleischer ring Sunflower cataract Copper metabolism
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Safety and efficacy of keratorefractive surgery in diabetes mellitus:A clinical review 认领 引用
2
作者 Ranjan Kumar Behera Parul Chawla Gupta +1 位作者 Arvind Kumar Morya Srishti Khullar 《World Journal of Clinical Cases》 2026年第4期1-11,共11页
Keratorefractive surgery is typically performed to correct refractive errors,resulting in good postoperative outcomes.Certain conditions,such as autoimmune diseases,metabolic diseases like diabetes mellitus(DM),and th... Keratorefractive surgery is typically performed to correct refractive errors,resulting in good postoperative outcomes.Certain conditions,such as autoimmune diseases,metabolic diseases like diabetes mellitus(DM),and the use of some drugs,may be absolutely or relatively contraindicated for refractive surgery.DM is a multisystemic disorder affecting various organs and can result in retinopathy,nephropathy,and neuropathy.Persistent hyperglycemia leads to various pathophysiological changes that can alter the biomechanical profile and the wound healing process of the cornea.Proper patient counselling,optimizing blood glucose levels,and frequent follow-up visits to monitor and manage potential complications,such as dry eye,non-healing epithelial defects,and neurotrophic keratitis,are essential for refractive surgeons.Laser-assisted in situ keratomileusis is preferred over photorefractive keratectomy due to its faster healing process.Cataract surgery in people with diabetes warrants various preoperative,intraoperative,and postoperative considerations for the best visual outcomes.This review focuses on the current evidence pertaining to various structural and functional corneal changes occurring in diabetics and their impact on keratorefractive procedures,thus providing a unified,clinically oriented framework to guide refractive surgeons in risk stratification,procedure selection,and postoperative management in patients with DM. 展开更多
关键词 Diabetes mellitus Refractive surgery Diabetic keratopathy Photorefractive keratectomy Advanced glycation end products
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Intricacies during pregnancy with gestational diabetes mellitus 认领 引用
3
作者 Richa Rattan Rimesh Pal +2 位作者 Parul Chawla Gupta Arvind Kumar Morya Ripunjay Prasad 《World Journal of Clinical Cases》 2025年第1期62-64,共3页
The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and ab... The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass spectrometry.Their analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to controls.Although these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods used.Furthermore,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics analysis.The study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for GDM.Predicting GDM risk during the first trimester or pre-conceptional period may offer more clinical relevance.Despite its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability. 展开更多
关键词 Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction
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CICARE based communication technique:A passage to faster and smoother visual rehabilitation in post cataract surgery patients 认领 引用 被引量：6
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作者 Arvind Kumar Morya Ranjan Kumar Behera +1 位作者 Parul Chawla Gupta Arshi Singh 《World Journal of Clinical Cases》 SCIE 2024年第36期6947-6949,共3页
Visual rehabilitation following cataract surgery is often an overlooked aspect.Healthcare providers have an important role in the counselling of the patients undergoing cataract surgery in clearing all their doubts th... Visual rehabilitation following cataract surgery is often an overlooked aspect.Healthcare providers have an important role in the counselling of the patients undergoing cataract surgery in clearing all their doubts thus alleviating all their fears and anxiety related to the procedure which will eventually lead to faster and smoother visual rehabilitation.Using standardised communication techniques like CICARE combined with conventional nursing and pain scoring systems can provide an objective and effective method in patient counselling and building a rapport with the patient for a faster visual recovery. 展开更多
关键词 visual Visual faster
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Diabetes is affecting everyone everywhere 认领 引用
5
作者 Parul Chawla Gupta Mona Duggal Arvind Kumar Morya 《World Journal of Diabetes》 SCIE 2024年第2期305-307,共3页
The article titled“Accessibility and Utilization of Healthcare Services Among Diabetic Patients:Is Diabetes a Poor Man’s Ailment?”gave insights into a pandemic systemic disease known as diabetes mellitus.This moder... The article titled“Accessibility and Utilization of Healthcare Services Among Diabetic Patients:Is Diabetes a Poor Man’s Ailment?”gave insights into a pandemic systemic disease known as diabetes mellitus.This modern-era pandemic affects everyone,regardless of their financial background.As a result,diabetes is not a systemic disease which just involves people of low socioeconomic status. 展开更多
关键词 Diabetes Incidence and prevalence Diabetes mellitus
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