The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to case...The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the core.However,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field recon-struction.Therefore,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex changes.Furthermore,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of reconstruction.Reconstruction experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed method.The results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed five.Further,the reconstructed ARD was within 2%,RDmaxwas maintained within 17.5%,and the number of RD≥10%was maintained within 10.Furthermore,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RDmaxwas within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.展开更多
Estimating spatial variation in crop transpiration coefficients(CTc) and aboveground biomass(AGB)rapidly and accurately by remote sensing can facilitate precision irrigation management in semiarid regions. This study ...Estimating spatial variation in crop transpiration coefficients(CTc) and aboveground biomass(AGB)rapidly and accurately by remote sensing can facilitate precision irrigation management in semiarid regions. This study developed and assessed a novel machine learning(ML) method for estimating CTc and AGB using time-series unmanned aerial vehicle(UAV)-based multispectral vegetation indices(VIs)of maize under several irrigation treatments at the field scale. Four ML regression methods: multiple linear regression(MLR), support vector regression(SVR), random forest regression(RFR), and adaptive boosting regression(ABR), were used to address the complex relationship between CTcand VIs. AGB was then estimated using exponential, logistic, sigmoid, and linear equations because of their clear mathematical formulations based on the optimal CTcestimation model. The UAV VIs-derived CTcusing the RFR estimation model yielded the highest accuracy(R2= 0.91, RMSE = 0.0526, and n RMSE = 9.07%). The normalized difference red-edge index, transformed chlorophyll absorption in reflectance index, and simple ratio contributed significantly to the RFR-based CTcmodel. The accuracy of AGB estimation using nonlinear methods was higher than that using the linear method. The exponential method yielded the highest accuracy(R2= 0.76, RMSE = 282.8 g m, and n RMSE = 39.24%) in both the 2018 and 2019 growing seasons. The study confirms that AGB estimation models based on cumulative CTcperformed well under several irrigation treatments using high-resolution time-series UAV multispectral VIs and can support irrigation management with high spatial precision at a field scale.展开更多
Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage station.Herein,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded ...Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage station.Herein,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded carbon nanotube foam(Co-doped NiO@WCNTF)as freestanding electrode is successfully prepared for high power and energy SCs.The WCNTF framework with high specific surface area provides three dimensional highly conductive network for fast charge transport and ensures high loading of active materials(9.2 mg/cm2).Moreover,porous Co-doped NiO nanosheets uniformly anchored on the WCNTF framework enable rapid charge kinetics due to the high intrinsic conductivity of Co-doped Ni O nanosheets and their good contact with conductive WCNTF substrate.As a result,the unique integrated electrode with 3D architecture exhibits an ultrahigh specific capacitance of 11.45 F/cm2 at 5 mA/cm2,outstanding rate capability(11.45 F/cm2 at 5 mA/cm2 and a capacitance retention of 86.2%at 30 mA/cm2)and good cycling stability,suggesting great potential for high performance supercapacitor.展开更多
In this study, flower-like mesoporous TiO_2 hierarchical spheres(FMTHSs) with ordered stratified structure and TiO_2 nanoparticles(TNPs) were synthesized via a facile solvothermal route and an etching reaction. Multil...In this study, flower-like mesoporous TiO_2 hierarchical spheres(FMTHSs) with ordered stratified structure and TiO_2 nanoparticles(TNPs) were synthesized via a facile solvothermal route and an etching reaction. Multilamellar vesicles(MTSVs) and unilamellar TiO_2/SiO_2 vesicles(UTSVs) were prepared using cetyltrimethylammonium bromide and didodecyldimethylammonium bromide as structure-directing agents under different solvothermal conditions. FMTHSs and TNPs were obtained from the etching reactions of MTSVs and UTSVs, respectively, in an alkaline system. FMTHSs display flower-like, ordered stratified structures on each petal. The thickness of the ordered stratified structure is approximately3–6 nm, and the number of layers is approximately 2–4. The FMTHSs2 electrode exhibits the first discharge capacity of 212.4 m A h g-1 at 0.2 C, which is higher than that of TNPs electrode(167.6 mA h g-1).The discharge specific capacity of FMTHSs2 electrode after 200 cycles at 1 C is 105.9 mA h g-1, which is higher than that of TNPs electrode(52.2 mA h g-1) after the same number of cycles. The outstanding performance of FMTHSs2 electrode is attributed to the advantages of FMTHSs. In particular, their own stratified structure can provide additional active sites for reactions. The hierarchical structure can provide short diffusion length for Li^+, large electrolyte–electrode contact area, and superior accommodation of the strain of Li+intercalation/deintercalation.展开更多
Two new myrinsol diterpenoids, euphordracunculins A(1) and B(2), together with three known analogues, euphorprolitherin B(3), proliferins A(4) and B(5),were isolated from the petroleum ether extract of the a...Two new myrinsol diterpenoids, euphordracunculins A(1) and B(2), together with three known analogues, euphorprolitherin B(3), proliferins A(4) and B(5),were isolated from the petroleum ether extract of the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated by means of extensive spectroscopic analysis(NMR and ESI-MS) and comparison with data reported in the literature.展开更多
Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic circuits.Nevertheless,the creation of biomimetic asymmetric ion channels nec...Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic circuits.Nevertheless,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic devices.In this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical stress.We have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.展开更多
The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between p...The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.展开更多
Chinese herbal medicines(CHMs)are one of the important bioresources of medicine,which works by unlocking nature’s ability to prevent diseases and recover from illnesses.Recently,it has ascended to the world stage and...Chinese herbal medicines(CHMs)are one of the important bioresources of medicine,which works by unlocking nature’s ability to prevent diseases and recover from illnesses.Recently,it has ascended to the world stage and become a global icon.Nowadays,a considerable of researches have focused on the quality evaluation of CHMs.However,it is difficult to meet the reasonable needs of human beings for safe drug use to evaluate the quality of a huge number of inferior goods for the CHMs contaminated by pesticides and heavy metals.Hence to explore an eligible medicinal plant cultivation pattern,which can provide high quality CHMs sustainably,is most promising.This review analyzed the situation and characteristics of medicinal plant resources in different periods,including wild-harvested and cultivated resources during different stages,putting forward that ecological cultivation must be the way to develop medicinal plant cultivation and to obtain high quality CHMs.展开更多
Objective: Biofertilizers are reliable alternatives to chemical fertilizers due to various advantages. However, the effect of biofertilizers on Salvia miltiorrhiza yield and quality and the possible mechanisms remain ...Objective: Biofertilizers are reliable alternatives to chemical fertilizers due to various advantages. However, the effect of biofertilizers on Salvia miltiorrhiza yield and quality and the possible mechanisms remain little known. Here, an experiment was conducted in S. miltiorrhiza field treated with two kinds of biofertilizers including Bacillus and microalgae.Methods: A field experiment was conducted on S. miltiorrhiza of one year old. The biofertilizers were applied at six treatments:(i) control check, CK;(ii) microalgae, VZ;(iii) Bacillus, TTB;(iv)microalgae + Bacillus(1:1), VTA;(v) microalgae + Bacillus(0.5:1), VTB;(vi) microalgae+Bacillus(1:0.5),VTC. Here, high-throughput sequencing, ICP-MS and UPLC were employed to systematically characterize changes of microbial diversity and structure composition, heavy metals content and bioactive compounds, respectively.Results: Compared to CK, root biomass increased by 29.31%-60.39%(P < 0.001). Meanwhile, bioactive compounds were higher than CK after the application of the biofertilizers, peculiarly in TTB and VTB.However, the content of Pb contents in roots significantly reduced by 46.03% and 37.58% respectively in VTC and TTB(P<0.05). VTA application notably increased the available nitrogen content by 53.03%(P<0.05), indicating the improvement of soil fertility. Significantly, bacterial and fungal Chao I diversity indices showed an increasing trend with biofertilizer application(P < 0.05), and biofertilizer amendment enriched the rhizosphere soil with beneficial microorganisms that have abilities on promoting plant growth(Achromobacter and Penicillium), adsorbing heavy metal(Achromobacter and Beauveria), controlling plant pathogen(Plectosphaerella, Lechevalieria, Sorangium, Phlebiopsis and Beauveria) and promoting the accumulation of metabolites(Beauveria and Phoma).Conclusion: Bacillus and microalgae biofertilizers improved the quality and biomass of S. miltiorrhiza by altering microbial communities in soil.展开更多
Objective: Flower herbs are an important category of traditional Chinese medicinal materials, some of which are used as healthcare tea in folk. However, the increasing adulteration of medicinal herbs is threatening co...Objective: Flower herbs are an important category of traditional Chinese medicinal materials, some of which are used as healthcare tea in folk. However, the increasing adulteration of medicinal herbs is threatening consumer safety. The adulteration of flower herbs and their healthcare tea products in the market were investigated.Methods: A total of 33 flower herb samples from several retail pharmacies in China were randomly collected and 27 flower healthcare tea samples were purchased online. They were identified using ITS2-based Traditional Chinese Medicine Database(TCMD). Additionally, Lonicerae Japonicae Flos and the adulterants were compared in the ITS2 secondary structures.Results: There were one adulterant(Inulae Flos) in flower herb materials and eight adulterants in healthcare tea samples. Inula linariifolia was an adulterate species of Inulae Flos, Robinia pseudoacacia was of Sophorae Flos, and Lonicera macranthoides was of Lonicerae Japonicae Flos. Sophorae Flos and Lonicerae Japonicae Flos were two healthcare tea products with high adulteration rates.Conclusion: The TCMD is powerful tool to identify flower herbs and the adulterants that frequently occurred in the flower herb market, especially online shops.展开更多
Objective:To find a suitable ecological cultivation measure to solve the problem of root-knot nematode disease of Panax quinquefolium(Panacis Quinquefolii Radix)and the heavy metals accumulating in its roots.Methods:T...Objective:To find a suitable ecological cultivation measure to solve the problem of root-knot nematode disease of Panax quinquefolium(Panacis Quinquefolii Radix)and the heavy metals accumulating in its roots.Methods:Three-year-old P.quinquefolium was treated with four different combinations of microbial inoculant(MI)and garbage fermentation liquid(GFL)[the joint application of‘TuXiu’MI and Fifty potassium MI(TF),the combination use of‘No.1'MI and Fifty potassium MI(NF),‘Gulefeng’poly-γ-glutamic acid MI(PGA),GFL],and the untreated control(CK).Here,high-throughput sequencing,ICP-MS and UPLC were employed to systematically characterize changes of microbial diversity and structure composition,heavy metals(As,Cd and Pb)content and ginsenoside content among different treatments.Results:The results revealed that different MIs and GFL could increase the root dry weight of P.quinquefolium,PGA enhanced it by 83.24%,followed by GFL(49.93%),meanwhile,PGA and GFL were able to lessen root-knot nematode disease incidence by 57.25%and 64.35%.The treatment of PGA and GFL can also effectively reduce heavy metals in roots.The As content in GFL and PGA was decreased by 52.17%and 43.48%respectively,while the Cd and Pb contents of GFL and PGA was decreased somewhat.Additionally,the content of total ginsenosides was increased by 42.14%and 42.07%,in response to TF and NF,respectively.Our metagenomic analysis showed that the relative abundance of particular soil microbial community members related to the biocontrol of root-knot nematode disease and plant pathogen(i.e.,Chaetomium in NF,Xylari in GFL,and Microascus in PGA),heavy metal bioremediation(Hyphomacrobium in PGA and Xylaria in GFL),and nitrogen fixation(Nordella and Nitrospira in TF)was significantly increased;notably,potential harmful microflora,such as Plectosaphaerella and Rhizobacter,were more abundant in the control group.Conclusion:MI and GFL could improve the quality of P.quinquefolium by modifying its rhizosphere microbial community structure and composition,both of them are beneficial to the development of ecological cultivation of P.quinquefolium.展开更多
The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography ...The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and classification.Nanotechnology has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging modes.In this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging strategies.We also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives.展开更多
Metal oxide-based nanomaterials are extensively studied as anode materials for lithium-ion batteries(LIBs)because of their high energy densities.However,the practical application of these nanomaterials is hindered by ...Metal oxide-based nanomaterials are extensively studied as anode materials for lithium-ion batteries(LIBs)because of their high energy densities.However,the practical application of these nanomaterials is hindered by their fast capacity degradation resulting from the large volume expansion upon lithiation.In this work,CeO2@resorcinol and formaldehyde resin(RF)hollow nanospheres were prepared by polymerization of resorcinol and formaldehyde on the CeO2hollow sphere surface.Mesoporous double-shelled CeO2@C hollow nanospheres were obtained by carbonizing RF in CeO2@RF.The resulting composites display a typical double-shell hollow structure with a cavity diameter of approximately 60 nm.The thickness of the CeO2layer is approximately 20 nm,and the carbon shell of the outer layer is approximately 15 nm.This double-shelled structure,in which the CeO2hollow nanospheres are uniformly dispersed inside the carbon nanoshells,can simultaneously act as a conductive framework and a protective buffer layer to restrain volume variations.The fabricated nanospheres exhibit a remarkable electrochemical performance as anodes for LIBs,displaying a high reversible capability(1309.1 mA h g-1at 100 mA g-1),stable cycling life(903.6 mA h g-1after 300 cycles at 100 mA g-1),and good rate capacity(761.6 mA h g-1at 1000 mA g-1).This effective strategy provides new insight into the design and synthesis of other composite electrodes for high-performance lithium-ion batteries.展开更多
In the era of the Internet of Things,Bluetooth low energy(BLE/BTLE)plays an important role as a wellknown wireless communication technology.While the security and privacy of BLE have been analyzed and fixed several ti...In the era of the Internet of Things,Bluetooth low energy(BLE/BTLE)plays an important role as a wellknown wireless communication technology.While the security and privacy of BLE have been analyzed and fixed several times,the threat of side-channel attacks to BLE devices is still not well understood.In this work,we highlight a side-channel threat to the re-keying protocol of BLE.This protocol uses a fixed long term key for generating session keys,and the leakage of the long term key could render the encryption of all the following(and previous)connections useless.Our attack exploits the side-channel leakage of the re-keying protocol when it is implemented on embedded devices.In particular,we present successful correlation electromagnetic analysis and deep learning based profiled analysis that recover long term keys of BLE devices.We evaluate our attack on an ARM Cortex-M4 processor(Nordic Semiconductor nRF52840)running Nimble,a popular open-source BLE stack.Our results demonstrate that the long term key can be recovered within only a small amount of electromagnetic traces.Further,we summarize the features and limitations of our attack,and suggest a range of countermeasures to prevent it.展开更多
基金supported by the National Natural Science Foundation of China(No.12305344)the 2023 Anhui university research project of China(No.2023AH052179).
摘要The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the core.However,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field recon-struction.Therefore,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex changes.Furthermore,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of reconstruction.Reconstruction experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed method.The results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed five.Further,the reconstructed ARD was within 2%,RDmaxwas maintained within 17.5%,and the number of RD≥10%was maintained within 10.Furthermore,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RDmaxwas within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.
基金funded by the National Natural Science Foundation of China (51979233)the Natural Science Basic Research Plan in Shaanxi Province of China (2022JQ-363)。
摘要Estimating spatial variation in crop transpiration coefficients(CTc) and aboveground biomass(AGB)rapidly and accurately by remote sensing can facilitate precision irrigation management in semiarid regions. This study developed and assessed a novel machine learning(ML) method for estimating CTc and AGB using time-series unmanned aerial vehicle(UAV)-based multispectral vegetation indices(VIs)of maize under several irrigation treatments at the field scale. Four ML regression methods: multiple linear regression(MLR), support vector regression(SVR), random forest regression(RFR), and adaptive boosting regression(ABR), were used to address the complex relationship between CTcand VIs. AGB was then estimated using exponential, logistic, sigmoid, and linear equations because of their clear mathematical formulations based on the optimal CTcestimation model. The UAV VIs-derived CTcusing the RFR estimation model yielded the highest accuracy(R2= 0.91, RMSE = 0.0526, and n RMSE = 9.07%). The normalized difference red-edge index, transformed chlorophyll absorption in reflectance index, and simple ratio contributed significantly to the RFR-based CTcmodel. The accuracy of AGB estimation using nonlinear methods was higher than that using the linear method. The exponential method yielded the highest accuracy(R2= 0.76, RMSE = 282.8 g m, and n RMSE = 39.24%) in both the 2018 and 2019 growing seasons. The study confirms that AGB estimation models based on cumulative CTcperformed well under several irrigation treatments using high-resolution time-series UAV multispectral VIs and can support irrigation management with high spatial precision at a field scale.
基金the National Natural Science Foundation of China(U1710122,51862035 and 21773293)the Science and Technology Project of Jiangxi Province(20181ACH80008,20181ACE50012,20192BCD40017 and 20192ACB80002)+1 种基金Jiangxi Double Thousand Talent Program(S2018LQCQ0016)Suzhou Science and Technology Plan Projects(SYG201831)。
摘要Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage station.Herein,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded carbon nanotube foam(Co-doped NiO@WCNTF)as freestanding electrode is successfully prepared for high power and energy SCs.The WCNTF framework with high specific surface area provides three dimensional highly conductive network for fast charge transport and ensures high loading of active materials(9.2 mg/cm2).Moreover,porous Co-doped NiO nanosheets uniformly anchored on the WCNTF framework enable rapid charge kinetics due to the high intrinsic conductivity of Co-doped Ni O nanosheets and their good contact with conductive WCNTF substrate.As a result,the unique integrated electrode with 3D architecture exhibits an ultrahigh specific capacitance of 11.45 F/cm2 at 5 mA/cm2,outstanding rate capability(11.45 F/cm2 at 5 mA/cm2 and a capacitance retention of 86.2%at 30 mA/cm2)and good cycling stability,suggesting great potential for high performance supercapacitor.
基金supported by the National Natural Science Foundation of China (Grant Nos.51372134 and 51572124)
摘要In this study, flower-like mesoporous TiO_2 hierarchical spheres(FMTHSs) with ordered stratified structure and TiO_2 nanoparticles(TNPs) were synthesized via a facile solvothermal route and an etching reaction. Multilamellar vesicles(MTSVs) and unilamellar TiO_2/SiO_2 vesicles(UTSVs) were prepared using cetyltrimethylammonium bromide and didodecyldimethylammonium bromide as structure-directing agents under different solvothermal conditions. FMTHSs and TNPs were obtained from the etching reactions of MTSVs and UTSVs, respectively, in an alkaline system. FMTHSs display flower-like, ordered stratified structures on each petal. The thickness of the ordered stratified structure is approximately3–6 nm, and the number of layers is approximately 2–4. The FMTHSs2 electrode exhibits the first discharge capacity of 212.4 m A h g-1 at 0.2 C, which is higher than that of TNPs electrode(167.6 mA h g-1).The discharge specific capacity of FMTHSs2 electrode after 200 cycles at 1 C is 105.9 mA h g-1, which is higher than that of TNPs electrode(52.2 mA h g-1) after the same number of cycles. The outstanding performance of FMTHSs2 electrode is attributed to the advantages of FMTHSs. In particular, their own stratified structure can provide additional active sites for reactions. The hierarchical structure can provide short diffusion length for Li^+, large electrolyte–electrode contact area, and superior accommodation of the strain of Li+intercalation/deintercalation.
基金financially supported by the National Natural Science Foundation of China(No.21162044)the Mid-aged and Young Academic and Technical Leader Raising Foundation of Yunnan Province(No.2010C1040)
摘要Two new myrinsol diterpenoids, euphordracunculins A(1) and B(2), together with three known analogues, euphorprolitherin B(3), proliferins A(4) and B(5),were isolated from the petroleum ether extract of the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated by means of extensive spectroscopic analysis(NMR and ESI-MS) and comparison with data reported in the literature.
基金supported by the National Natural Science Foundation of China(Nos.52273305,21975209,52025132,T2241022,21621091,22021001,and 22121001)the 111 Project(Nos.B17027,B16029)+4 种基金the Fundamental Research Funds for the Central Universities(No.20720230037)the National Science Foundation of Fujian Province of China(Nos.2022J02059,2023J05012)Natural Science Foundation of XiamenChina(No.3502Z20227010)the New Cornerstone Science Foundation through the XPLORER PRIZE。
摘要Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic circuits.Nevertheless,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic devices.In this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical stress.We have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.
基金the“Hundred Talents Project”of Chinese Academy of Science and“High-end Science and Technology Talents Program”’of Yunnan Province(2011HA008)。
摘要The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.
基金supported by grants from the National Key Research and Development Program of China(2019YFC1604701)。
摘要Chinese herbal medicines(CHMs)are one of the important bioresources of medicine,which works by unlocking nature’s ability to prevent diseases and recover from illnesses.Recently,it has ascended to the world stage and become a global icon.Nowadays,a considerable of researches have focused on the quality evaluation of CHMs.However,it is difficult to meet the reasonable needs of human beings for safe drug use to evaluate the quality of a huge number of inferior goods for the CHMs contaminated by pesticides and heavy metals.Hence to explore an eligible medicinal plant cultivation pattern,which can provide high quality CHMs sustainably,is most promising.This review analyzed the situation and characteristics of medicinal plant resources in different periods,including wild-harvested and cultivated resources during different stages,putting forward that ecological cultivation must be the way to develop medicinal plant cultivation and to obtain high quality CHMs.
基金supported by grants from the CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021-I2M-1-071)。
摘要Objective: Biofertilizers are reliable alternatives to chemical fertilizers due to various advantages. However, the effect of biofertilizers on Salvia miltiorrhiza yield and quality and the possible mechanisms remain little known. Here, an experiment was conducted in S. miltiorrhiza field treated with two kinds of biofertilizers including Bacillus and microalgae.Methods: A field experiment was conducted on S. miltiorrhiza of one year old. The biofertilizers were applied at six treatments:(i) control check, CK;(ii) microalgae, VZ;(iii) Bacillus, TTB;(iv)microalgae + Bacillus(1:1), VTA;(v) microalgae + Bacillus(0.5:1), VTB;(vi) microalgae+Bacillus(1:0.5),VTC. Here, high-throughput sequencing, ICP-MS and UPLC were employed to systematically characterize changes of microbial diversity and structure composition, heavy metals content and bioactive compounds, respectively.Results: Compared to CK, root biomass increased by 29.31%-60.39%(P < 0.001). Meanwhile, bioactive compounds were higher than CK after the application of the biofertilizers, peculiarly in TTB and VTB.However, the content of Pb contents in roots significantly reduced by 46.03% and 37.58% respectively in VTC and TTB(P<0.05). VTA application notably increased the available nitrogen content by 53.03%(P<0.05), indicating the improvement of soil fertility. Significantly, bacterial and fungal Chao I diversity indices showed an increasing trend with biofertilizer application(P < 0.05), and biofertilizer amendment enriched the rhizosphere soil with beneficial microorganisms that have abilities on promoting plant growth(Achromobacter and Penicillium), adsorbing heavy metal(Achromobacter and Beauveria), controlling plant pathogen(Plectosphaerella, Lechevalieria, Sorangium, Phlebiopsis and Beauveria) and promoting the accumulation of metabolites(Beauveria and Phoma).Conclusion: Bacillus and microalgae biofertilizers improved the quality and biomass of S. miltiorrhiza by altering microbial communities in soil.
基金supported by grants from the National Natural Science Foundation of China (no. 81673552)CAMS Innovation Fund for Medical Sciences(CIFMS, 2016-I2M-3-016)
摘要Objective: Flower herbs are an important category of traditional Chinese medicinal materials, some of which are used as healthcare tea in folk. However, the increasing adulteration of medicinal herbs is threatening consumer safety. The adulteration of flower herbs and their healthcare tea products in the market were investigated.Methods: A total of 33 flower herb samples from several retail pharmacies in China were randomly collected and 27 flower healthcare tea samples were purchased online. They were identified using ITS2-based Traditional Chinese Medicine Database(TCMD). Additionally, Lonicerae Japonicae Flos and the adulterants were compared in the ITS2 secondary structures.Results: There were one adulterant(Inulae Flos) in flower herb materials and eight adulterants in healthcare tea samples. Inula linariifolia was an adulterate species of Inulae Flos, Robinia pseudoacacia was of Sophorae Flos, and Lonicera macranthoides was of Lonicerae Japonicae Flos. Sophorae Flos and Lonicerae Japonicae Flos were two healthcare tea products with high adulteration rates.Conclusion: The TCMD is powerful tool to identify flower herbs and the adulterants that frequently occurred in the flower herb market, especially online shops.
基金supported by grants from the National Key Research and Development Program of China (No.2019YFC1604701)
摘要Objective:To find a suitable ecological cultivation measure to solve the problem of root-knot nematode disease of Panax quinquefolium(Panacis Quinquefolii Radix)and the heavy metals accumulating in its roots.Methods:Three-year-old P.quinquefolium was treated with four different combinations of microbial inoculant(MI)and garbage fermentation liquid(GFL)[the joint application of‘TuXiu’MI and Fifty potassium MI(TF),the combination use of‘No.1'MI and Fifty potassium MI(NF),‘Gulefeng’poly-γ-glutamic acid MI(PGA),GFL],and the untreated control(CK).Here,high-throughput sequencing,ICP-MS and UPLC were employed to systematically characterize changes of microbial diversity and structure composition,heavy metals(As,Cd and Pb)content and ginsenoside content among different treatments.Results:The results revealed that different MIs and GFL could increase the root dry weight of P.quinquefolium,PGA enhanced it by 83.24%,followed by GFL(49.93%),meanwhile,PGA and GFL were able to lessen root-knot nematode disease incidence by 57.25%and 64.35%.The treatment of PGA and GFL can also effectively reduce heavy metals in roots.The As content in GFL and PGA was decreased by 52.17%and 43.48%respectively,while the Cd and Pb contents of GFL and PGA was decreased somewhat.Additionally,the content of total ginsenosides was increased by 42.14%and 42.07%,in response to TF and NF,respectively.Our metagenomic analysis showed that the relative abundance of particular soil microbial community members related to the biocontrol of root-knot nematode disease and plant pathogen(i.e.,Chaetomium in NF,Xylari in GFL,and Microascus in PGA),heavy metal bioremediation(Hyphomacrobium in PGA and Xylaria in GFL),and nitrogen fixation(Nordella and Nitrospira in TF)was significantly increased;notably,potential harmful microflora,such as Plectosaphaerella and Rhizobacter,were more abundant in the control group.Conclusion:MI and GFL could improve the quality of P.quinquefolium by modifying its rhizosphere microbial community structure and composition,both of them are beneficial to the development of ecological cultivation of P.quinquefolium.
基金supported by the National Key R&D Program of China(2021YFA0909900)。
摘要The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and classification.Nanotechnology has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging modes.In this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging strategies.We also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives.
基金National Natural Science Foundation of China(Grant No.51572134,51372124,51503108)。
摘要Metal oxide-based nanomaterials are extensively studied as anode materials for lithium-ion batteries(LIBs)because of their high energy densities.However,the practical application of these nanomaterials is hindered by their fast capacity degradation resulting from the large volume expansion upon lithiation.In this work,CeO2@resorcinol and formaldehyde resin(RF)hollow nanospheres were prepared by polymerization of resorcinol and formaldehyde on the CeO2hollow sphere surface.Mesoporous double-shelled CeO2@C hollow nanospheres were obtained by carbonizing RF in CeO2@RF.The resulting composites display a typical double-shell hollow structure with a cavity diameter of approximately 60 nm.The thickness of the CeO2layer is approximately 20 nm,and the carbon shell of the outer layer is approximately 15 nm.This double-shelled structure,in which the CeO2hollow nanospheres are uniformly dispersed inside the carbon nanoshells,can simultaneously act as a conductive framework and a protective buffer layer to restrain volume variations.The fabricated nanospheres exhibit a remarkable electrochemical performance as anodes for LIBs,displaying a high reversible capability(1309.1 mA h g-1at 100 mA g-1),stable cycling life(903.6 mA h g-1after 300 cycles at 100 mA g-1),and good rate capacity(761.6 mA h g-1at 1000 mA g-1).This effective strategy provides new insight into the design and synthesis of other composite electrodes for high-performance lithium-ion batteries.
基金supported by the National Natural Science Foundation of China under Grant No.62072307。
摘要In the era of the Internet of Things,Bluetooth low energy(BLE/BTLE)plays an important role as a wellknown wireless communication technology.While the security and privacy of BLE have been analyzed and fixed several times,the threat of side-channel attacks to BLE devices is still not well understood.In this work,we highlight a side-channel threat to the re-keying protocol of BLE.This protocol uses a fixed long term key for generating session keys,and the leakage of the long term key could render the encryption of all the following(and previous)connections useless.Our attack exploits the side-channel leakage of the re-keying protocol when it is implemented on embedded devices.In particular,we present successful correlation electromagnetic analysis and deep learning based profiled analysis that recover long term keys of BLE devices.We evaluate our attack on an ARM Cortex-M4 processor(Nordic Semiconductor nRF52840)running Nimble,a popular open-source BLE stack.Our results demonstrate that the long term key can be recovered within only a small amount of electromagnetic traces.Further,we summarize the features and limitations of our attack,and suggest a range of countermeasures to prevent it.