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Machine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury 认领 引用 被引量：1
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作者 Yigang Lv Zhen Li +10 位作者 Lusen Shi Huan Jian Fan Yang Jichuan Qiu Chao Li Peng Xiao Wendong Ruan Hao Li Xueying Li Shiqing Feng Hengxing Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2495-2505,共11页
Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study... Ferroptosis,a type of cell death that mainly involves iron metabolism imbalance and lipid peroxidation,is strongly correlated with the phagocytic response caused by bleeding after spinal cord injury.Thus,in this study,bulk RNA sequencing data(GSE47681 and GSE5296)and single-cell RNA sequencing data(GSE162610)were acquired from gene expression databases.We then conducted differential analysis and immune infiltration analysis.Atf3 and Piezo1 were identified as key ferroptosis genes through random forest and least absolute shrinkage and selection operator algorithms.Further analysis of single-cell RNA sequencing data revealed a close relationship between ferroptosis and cell types such as macrophages/microglia and their intrinsic state transition processes.Differences in transcription factor regulation and intercellular communication networks were found in ferroptosis-related cells,confirming the high expression of Atf3 and Piezo1 in these cells.Molecular docking analysis confirmed that the proteins encoded by these genes can bind cycloheximide.In a mouse model of T8 spinal cord injury,low-dose cycloheximide treatment was found to improve neurological function,decrease levels of the pro-inflammatory cytokine inducible nitric oxide synthase,and increase levels of the anti-inflammatory cytokine arginase 1.Correspondingly,the expression of the ferroptosis-related gene Gpx4 increased in macrophages/microglia,while the expression of Acsl4 decreased.Our findings reveal the important role of ferroptosis in the treatment of spinal cord injury,identify the key cell types and genes involved in ferroptosis after spinal cord injury,and validate the efficacy of potential drug therapies,pointing to new directions in the treatment of spinal cord injury. 展开更多
关键词 bioinformatic analyses bulk-RNA sequencing cellular communication analysis ferroptosis machine learning analysis neurological function RNA velocity analysis single-cell RNA sequencing therapeutic drugs transcription factor analysis
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Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury 认领 引用
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作者 Zhongze Yuan Lusen Shi +15 位作者 Xiao-Na Tao Xiangchuang Fan Han Zheng Yifan Shang Xiaoqing Zhao Fan Yang Hui Lin Peng Xiao Bo Chu Jichuan Qiu Shaohui Zong Ning Ran Xiaohong Kong Jin-Peng Sun Hengxing Zhou Shiqing Feng 《Bone Research》 SCIE CAS CSCD 2026年第1期62-81,共20页
Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial re... Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial research has reported the therapeutic potential of Omega-3 fatty acids for the central nervous system,particularly after traumatic SCI.Omega-3 fatty acids may contribute to improving SCI recovery through their anti-inflammatory,anti-oxidative,neurotrophic,and membrane integrity-preserving properties.These functions of Omega-3 fatty acids are primarily mediated via the activation of G protein-coupled receptor 120(GPR120),commonly known as the fish oil-specific receptor.Advancements in understanding of the molecular mechanisms of GPR120’s recognition of Omega-3 fatty acids and its downstream signaling mechanisms has significantly promoted research on the pharmacological potential of Omega-3 fatty acids and the development of highly selective and high-affinity alternatives.This review aims to provide in-depth analysis of the comprehensive therapeutic potential of Omega-3 fatty acids for SCI and its accompanying complications,and the prospects for developing novel drugs based on the recognition of Omega-3 fatty acids by GPR120. 展开更多
关键词 central nervous systemparticularly impairment neural circuitsleading spinal cord injury traumatic spinal cord injury omega fatty acids sensory functions traumatic spinal cord injury sci neural circuits
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Rainfall and water temperature co-drive changes in structure and assembly of prokaryotic and eukaryotic communities in a subtropical riverine reservoir 认领 引用
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作者 Qihang ZHAO Jun ZUO +7 位作者 Baiyu CUI Xinyue REN Xiang HU Tianchi SUN Zeshuang WANG Peng XIAO He ZHANG Renhui LI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第1期251-267,共17页
Microbial communities play indispensable roles in the biogeochemical cycling of river ecosystems.However,the response patterns of microbial community diversity,niche breadth,and assembly to rainfall disturbances in co... Microbial communities play indispensable roles in the biogeochemical cycling of river ecosystems.However,the response patterns of microbial community diversity,niche breadth,and assembly to rainfall disturbances in complex mountainous riverine reservoirs remain inadequately understood.We employed high-throughput sequencing of 16S and 18S ribosomal RNA genes,along with multivariate statistical methods to systematically investigate prokaryotic and eukaryotic microorganisms in the riverine Zhaoshandu Reservoir,Wenzhou,Zhejiang,East China.Results show significant temporal heterogeneity in both prokaryotic and eukaryotic microbial communities,with eukaryotic microbes showing more pronounced temporal variation.Canonical correspondence analysis revealed that rainfall and water temperature were the key drivers shaping microbial communities.Additionally,eukaryotic microorganisms exhibited a more pronounced response to rainfall and water temperature compared to prokaryotes.Modified stochasticity ratio model indicated that deterministic processes predominantly governed microbial community assembly,with stronger deterministic processes in eukaryotic compared to prokaryotic microorganisms.Rainfall has significantly altered water quality,notably increasing phosphorus concentration in the water column.Total phosphorus and total nitrogen showed significant correlations with the niche breadth of prokaryotic and eukaryotic microorganisms,and phosphorus nutrients served as keystones and playing indispensable roles in their co-occurrence networks.A structural equation model confirmed the notable impacts of rainfall and water temperature on microbial community diversity,further revealing that rainfall indirectly influenced the niche breadth and co-occurrence relationships of microbial communities by altering phosphorus concentrations.The findings underscore the influence of rainfall and water temperature on microbial distribution,highlighting the sensitivity of riverine reservoir ecosystems to climate change. 展开更多
关键词 riverine reservoir rainfall disturbance ecological process co-occurrence network phosphorus
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Emerging inorganic amorphous solid-state electrolytes in all-solid-state lithium batteries:From crystallographic order to atomic and lattice disorder 认领 引用
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作者 Yijie Yan Shuxian Zhang +6 位作者 Xiaoge Man Qingyu Li Haoyuan Xue Peng Xiao Yuanchang Shi Longwei Yin Rutao Wang 《eScience》 SCIE CSCD 2026年第4期57-74,共18页
Solid-state electrolytes(SEs)are the“blood vessels”in all-solid-state batteries(ASSBs),providing essential ion channels.In past decades,SE design has been mainly carried out within ordered crystalline frameworks,whi... Solid-state electrolytes(SEs)are the“blood vessels”in all-solid-state batteries(ASSBs),providing essential ion channels.In past decades,SE design has been mainly carried out within ordered crystalline frameworks,which is understandable for achieving well-defined ion transport pathways.However,the large impedance,poor interfaces,and dendrite penetration brought about by polycrystalline grain boundaries have always been the inherent drawbacks of crystalline SEs.Recently,tailoring disorder in crystalline SEs to achieve local atomic disorder or amorphous-state lattice disorder has emerged as an interesting strategy.In this review,we outline the working mechanism of disorder in SEs and highlight the prospects for amorphous solid electrolytes(ASEs)in advanced ASSBs,especially low-temperature ASSBs.From atomic disorder to lattice disorder,we discuss in depth the disorder-induced ion-conduction mechanism as well as properties,applications,and preparation methods.An interesting ASE closed-loop design and prediction framework is provided to meet the requirements for future ASSBs.After presenting these insights,we offer our view on the future development of ASEs. 展开更多
关键词 Solid-state electrolytes Crystallographic order Atomic disorder Lattice disorder All-solid-state lithium batteries
未成年人下颌骨成釉细胞瘤的个体化序列治疗临床研究 认领 引用
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作者 彭笑 王泽宇 +4 位作者 陈默 王栋 韩瑞 刘畅 张凯 《实用口腔医学杂志》 CAS CSCD 北大核心 2026年第1期103-108,共6页
目的:探讨个体化序列治疗未成年人下颌骨经典型成釉细胞瘤(AM)的临床疗效。方法:纳入未成年下颌骨经典型AM患者36例,根据患者年龄、影像检查及病理分型采用序列法进行治疗。其中大型囊性经典型AM先行开窗减压术,术后每3个月复诊摄片,适... 目的:探讨个体化序列治疗未成年人下颌骨经典型成釉细胞瘤(AM)的临床疗效。方法:纳入未成年下颌骨经典型AM患者36例,根据患者年龄、影像检查及病理分型采用序列法进行治疗。其中大型囊性经典型AM先行开窗减压术,术后每3个月复诊摄片,适时行内镜辅助下精准刮治;实性/多囊经典型AM直接行内镜辅助下精准刮治,术后定期(同前)复诊摄片。对于复发患者可续行内镜辅助下精准刮治以保存颌骨形态及相关重要解剖结构,此后继续定期复诊摄片观察病灶愈合情况及有无复发。针对再次刮治术后复发者,根据患者及家属意愿可行截骨修复治疗。对数据进行多因素Cox回归分析,绘制无病生存函数曲线,以确定与疾病复发相关的独立影响因素。采用SPSS21.0软件对数据进行统计学分析。结果:36例患者中32例经首次刮治术后无复发,骨质生长情况良好,未出现并发症。4例患者经首次刮治术后复发,其中滤泡型3例,丛状型1例。复发患者中3例续行内镜辅助下精准刮治,术后随访至今未见肿瘤复发,1例经二次刮治术后复发,患者成年后行截骨修复术。36例患者首次刮治术后无病生存函数曲线显示,滤泡型的复发风险高于丛状型(P<0.001);多房状+蜂窝状的复发风险高于单房状(P<0.001)。结论:序列法作为一种个体化治疗方法,能对未成年人下颌骨经典型AM起到良好的治疗效果。 展开更多
关键词 经典型AM 未成年人 序列法 下颌骨 个体化
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致密砂岩气层核磁孔隙度校正模型构建 认领 引用
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作者 谢冰 夏小勇 +4 位作者 王跃祥 韩冰 彭骁 朱绍武 何强 《核电子学与探测技术》 CAS 北大核心 2026年第2期257-262,共6页
为研究含气饱和度对致密砂岩储层核磁孔隙度的影响,本研究在四川盆地川西北地区三叠系须家河组选取4块代表性岩心,开展甲烷(CH4)驱水状态的核磁共振实验,获得7种不同饱和状态的核磁共振T2谱及核磁孔隙度数据。在系统分析含气饱和... 为研究含气饱和度对致密砂岩储层核磁孔隙度的影响,本研究在四川盆地川西北地区三叠系须家河组选取4块代表性岩心,开展甲烷(CH4)驱水状态的核磁共振实验,获得7种不同饱和状态的核磁共振T2谱及核磁孔隙度数据。在系统分析含气饱和度对核磁孔隙度影响规律的基础上,构建了不同含气饱和度下的致密砂岩储层孔隙度校正模型。计算结果表明:利用该校正模型得到的核磁孔隙度与岩心分析孔隙度的平均相对误差介于7.06%~7.45%之间,证实了本研究提出模型的可靠性。 展开更多
关键词 核磁孔隙度 含气饱和度 致密砂岩 校正 核磁孔隙度差
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黄精养肌方通过抑制肌间脂肪浸润改善肌少症的作用研究 认领 引用
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作者 郑力铭 王达 +5 位作者 孙传睿 刘治泽 彭啸 燕锡童 李玲慧 魏戌 《中国中医骨伤科杂志》 2026年第1期107-112,共6页
目的:探讨黄精养肌方通过抑制肌间脂肪浸润改善肌少症小鼠肌肉功能的作用及机制。方法:采用8月龄SAMP8小鼠作为肌少症模型,随机分为模型组、黄精养肌方低、中、高剂量组(4.94,9.88,19.76g/(kg·d)),并以同龄SAMR1小鼠作为正常对照... 目的:探讨黄精养肌方通过抑制肌间脂肪浸润改善肌少症小鼠肌肉功能的作用及机制。方法:采用8月龄SAMP8小鼠作为肌少症模型,随机分为模型组、黄精养肌方低、中、高剂量组(4.94,9.88,19.76g/(kg·d)),并以同龄SAMR1小鼠作为正常对照组。干预8周后,检测小鼠抓力与跑步耐力,称量肌肉湿重并计算肌重/体重比,通过HE染色观察肌纤维形态并测量横截面积,通过油红O染色和Perilipin-1免疫荧光染色评估肌间脂肪浸润,采用ELISA法检测血清炎症因子(TNF-α,IL-6)及血脂(总胆固醇、甘油三酯)水平。结果:与模型组相比,黄精养肌方中、高剂量能显著增加小鼠腓肠肌与股四头肌的肌重/体重比,差异有统计学意义(P0.05)。结论:黄精养肌方能有效改善肌少症小鼠的肌肉质量、力量及功能,其作用机制可能与抑制肌间脂肪浸润及降低相关炎症水平有关。 展开更多
关键词 肌少症 黄精养肌方 肌间脂肪浸润 炎症因子
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基于德尔菲法的肌少症中医四诊信息辨识体系构建 认领 引用
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作者 彭啸 刘治泽 +7 位作者 燕锡童 张志文 王达 郑力铭 金子开 朱立国 李玲慧 魏戌 《中国中医骨伤科杂志》 2026年第1期101-106,共6页
目的:构建规范、实用的肌少症中医四诊信息辨识工具,为肌少症中医辨证分型及临床诊疗提供标准化参考工具。方法:结合文献研究、半结构化访谈与头脑风暴法,系统梳理肌少症中医四诊相关信息,初步构建初始条目池;遴选中医骨伤科学、中医诊... 目的:构建规范、实用的肌少症中医四诊信息辨识工具,为肌少症中医辨证分型及临床诊疗提供标准化参考工具。方法:结合文献研究、半结构化访谈与头脑风暴法,系统梳理肌少症中医四诊相关信息,初步构建初始条目池;遴选中医骨伤科学、中医诊断学、方法学、统计学、中西医结合等领域权威专家,采用德尔菲法开展两轮专家咨询,以重要性评分、变异系数、满分率为核心筛选指标,结合专家修订意见优化条目,最终确立辨识体系框架及核心内容;通过信度分析验证体系可靠性。结果:研究构建了包含823个条目的初始条目池,经初筛后形成包含214个条目的第一轮德尔菲咨询问卷。依据专家反馈修订后,形成含136个条目的第二轮问卷;进一步剔除5个不符合筛选标准的条目,最终确立包含发病因素9项、临床症状90项(主证6项、兼证84项)、舌象21项、脉象11项,共计131个条目的辨识体系。两轮咨询各回收有效问卷25份,累计50份,25位受邀专家全程参与,专家积极系数均为100%,权威系数分别为0.892和0.900。结论:本研究构建的肌少症中医四诊信息辨识体系具有良好的科学性、权威性和实用性,可为临床规范化采集肌少症中医四诊信息、精准辨证提供可靠参考工具。 展开更多
关键词 肌少症 德尔菲法 中医四诊信息 证候辨识
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Revealing Hetero-Deformation Induced(HDI)Hardening and Dislocation Activity in a Dual-Heterostructure Magnesium Matrix Composite 认领 引用 被引量：2
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作者 Lingling Fan Ran Ni +7 位作者 Lingbao Ren Peng Xiao Ying Zeng Dongdi Yin Hajo Dieringa Yuanding Huang Gaofeng Quan Wei Feng 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2025年第2期902-921,共20页
Integrating a heterogeneous structure can significantly enhance the strength-ductility synergy of composites.However,the relationship between hetero-deformation induced(HDI)strain hardening and dislocation activity ca... Integrating a heterogeneous structure can significantly enhance the strength-ductility synergy of composites.However,the relationship between hetero-deformation induced(HDI)strain hardening and dislocation activity caused by heterogeneous structures in the magnesium matrix composite remains unclear.In this study,a dual-heterogeneous TiC/AZ61 composite exhibits significantly improved plastic elongation(PEL)by nearly one time compared to uniform FG composite,meanwhile maintaining a high strength(UTS:417 MPa).This is because more severe deformation inhomogeneity in heterogeneous structure leads to more geometrically necessary dislocations(GNDs)accumulation and stronger HDI stress,resulting in higher HDI hardening compared to FG and CG composites.During the early stage of plastic deformation,the pile-up types of GND in the FG zone and CG zone are significantly different.GNDs tend to form substructures in the FG zone instead of the CG zone.They only accumulate at grain boundaries of the CG region,thereby leading to obviously increased back stress in the CG region.In the late deformation stage,the elevated HDI stress activates the new〈c+a〉dislocations in the CG region,resulting in dislocation entanglements and even the formation of substructures,further driving the high hardening in the heterogeneous composite.However,For CG composite,〈c+a〉dislocations are not activated even under large plastic strains,and only〈a〉dislocations pile up at grain boundaries and twin boundaries.Our work provides an in-depth understanding of dislocation variation and HDI hardening in heterogeneous magnesium-based composites. 展开更多
关键词 Mg-matrix composite Heterogeneous structure HDI hardening GND density Dislocation
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Interfacial Elastic Film with Temperature Mediated-phase Transition Behavior for Tunable Suspended Sensing 认领 引用 被引量：1
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作者 Wei Zhou Yue Han +3 位作者 Peng Xiao Yi Yu Yu-Chao Wang Tao Chen 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第7期1155-1162,共8页
Controllably tuning the sensing performance of flexible mechanical sensors is important for them to realize on-demand sensing of various mechanical stimuli in different application scenarios.However,current regulating... Controllably tuning the sensing performance of flexible mechanical sensors is important for them to realize on-demand sensing of various mechanical stimuli in different application scenarios.However,current regulating strategies focus on the construction process of individual sensors,the response performance of the as-formed sensors is still hard to autonomously tune with external stimulus changes like human skin.Here,we propose a new strategy that realizes post-tuning of the sensing performance by introducing a temperature-dependent phase transition elastomer into the sensing film.Through an interfacially confined photopolymerization reaction,a graphene-based phase-transition elastomeric(GPTE)film with a robust interface and excellent conductivity is well-formed at the water/air interface.Benefiting from the crystallization-melt dynamic switching in the elastomer network,the GPTE film could experience the reversible transformation between soft(1.65 MPa)and stiff(12.27MPa)states,showing huge changes of elastic modulus up to seven times near the phase transition temperature(28.5℃).Furthermore,the GPTE film is designed into a suspended perceptual configuration realizing the dynamic detection of 3D deformation adapted to temperature changes with up to 3.5-fold difference in response sensitivity.Finally,the self-adaptive sensing behavior of temperature-mediated 3D deformation is demonstrated by the effective detection of the dynamic stimulation process of cold and hot water droplets by the GPTE suspended film.The proposed strategy of phase transition-induced post-tuning of sensing performance could greatly facilitate flexible mechanical sensors towards a more intelligent one. 展开更多
关键词 Phase transition elastomer Crystallization-melt switching Tunable modulus Suspended sensor Tunable sensing performance
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钻井液侵入致密气储层核磁共振T2响应数值模拟 认领 引用 被引量：1
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作者 万乔升 王跃祥 +5 位作者 潘柯宇 麻超 彭骁 王拓夫 彭婷婷 郭江峰 《测井技术》 CAS 2026年第1期28-41,共14页
核磁共振技术通过探测地层孔隙流体中氢核的弛豫衰减信号,反映储层孔隙流体信息,在储层勘探开发中应用广泛。但在实际测井过程中,钻井液侵入会导致地层孔隙流体类型发生变化,使核磁共振T2谱包含钻井液信号,进而降低了基于T2谱的... 核磁共振技术通过探测地层孔隙流体中氢核的弛豫衰减信号,反映储层孔隙流体信息,在储层勘探开发中应用广泛。但在实际测井过程中,钻井液侵入会导致地层孔隙流体类型发生变化,使核磁共振T2谱包含钻井液信号,进而降低了基于T2谱的流体识别及储层精细评价的可靠性。为了提高核磁共振测井解释的准确性,厘清钻井液侵入条件下岩石核磁共振T2响应具有重要意义。以致密气储层为例,构建不同钻井液类型、不同侵入程度的致密气储层三维数字岩心模型,利用随机游走法模拟了钻井液侵入条件下致密气储层核磁共振T2响应,并探究了内部磁场梯度、回波间隔、含氢指数及信噪比等因素对致密气储层核磁共振T2响应特征的影响。研究结果表明:随着水基钻井液侵入程度增加,T2谱中水峰和气峰发生耦合,峰值位置逐渐向长弛豫时间方向移动;随着油基钻井液侵入程度增加,T2谱中水峰和气峰同样会发生耦合现象,但峰值位置逐渐向短弛豫时间方向移动;随着内部磁场梯度及回波间隔的增加,T2谱中水峰、油峰、气峰的横向弛豫时间均向短弛豫时间方向移动,且气峰移动幅度大于水峰和油峰移动幅度;随着气相含氢指数的增加,T2谱中气峰信号强度逐渐增大;随着核磁共振数据信噪比的增加,反演的T2谱精度越来越高,建议采集的核磁共振数据信噪比大于40。该研究结果为钻井液侵入条件下岩石核磁共振测井解释奠定了理论基础。 展开更多
关键词 核磁共振 钻井液侵入 致密气 数字岩心 数值模拟 数学形态学 随机游走法
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Development and feasibility test of a fan-shaped hydrate simulator with a radius of 3 m 认领 引用
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作者 Ling-Ban Wang Xiao-Hui Wang +9 位作者 Yu-Hao Bu Zhen-Bin Xu Xian Sun Yi-Fei Sun Peng Xiao Qing-Ping Li Shou-Wei Zhou Praveen Linga Chang-Yu Sun Guang-Jin Chen 《Petroleum Science》 SCIE EI CAS CSCD 2025年第11期4794-4808,共15页
Large-scale physical simulation is essential for advancing our understanding of natural gas hydrates exploitation mechanism.However,cylinder-shaped simulators often face challenges in balancing large volume,controllab... Large-scale physical simulation is essential for advancing our understanding of natural gas hydrates exploitation mechanism.However,cylinder-shaped simulators often face challenges in balancing large volume,controllability,and comprehensive monitoring.In this study,we developed a fan columnshaped hydrate simulator(FCHS)with an internal angle of 6°,a radius of 3 m,and an inner height of0.3 m,resulting in an effective volume of~142 L.Moreover,the FCHS is equipped with an integrated"thermal-pressure-acoustic"sensing system,enabling in-situ monitoring of temperature,pressure,and P-wave velocity evolution during hydrate formation and dissociation process.The experimental results indicate that a pressure gradient successfully established from the reservoir center toward its boundaries during depressurization stage,and pressure propagation is relatively slow,resulting in a radial pressure difference of 3-4 MPa within a 3 m range.Once the system reaches pressure equilibrium,the pressure difference decreases to 0.3-0.4 MPa.The depressurization at the wellbore promotes hydrate dissociation in the near-well region,resulting in the radial temperature difference reaches~1.5℃ along the radial direction.The acoustic data reveals that a radial gradient in hydrate saturation gradually forms from the center to the boundary during depressurization-induced gas production.The evolutions of spatio-temporal multi-fields obtained in the FCHS are consist with that of field production.The FCHS proves to be a cutting-edge platform for experimental simulation of NGH exploitation and carbon sequestration processes. 展开更多
关键词 Methane hydrate Fan column-shaped simulator Joint detection method Production behavior Multi-field evolution
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桡骨远端骨折指南的方法学质量评价与综合分析 认领 引用
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作者 李锐 成永忠 +11 位作者 王朝鲁 王书元 刘峘 刘飞 彭晓 冯雷 苏大伟 赵叁昌 宋燕 尹晓冬 陈洋 李光耀 《世界中医药》 CAS 北大核心 2026年第3期471-477,484,共7页
目的:系统评价国内外桡骨远端骨折相关临床诊疗指南的方法学质量,分析其在制定过程中的优缺点,为临床实践提供参考,推动高质量指南的制定和应用。方法:文献来源于国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期... 目的:系统评价国内外桡骨远端骨折相关临床诊疗指南的方法学质量,分析其在制定过程中的优缺点,为临床实践提供参考,推动高质量指南的制定和应用。方法:文献来源于国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、PubMed、Web of Science、Embase等国内外数据库,国际指南协作网(GIN)、英国国家卫生与临床优化研究所(NICE)、苏格兰校际指南网络(SIGN)、美国国立指南库(NGC)等相关指南发布网站,以及医脉通、中华中医药学会、中国中西医结合学会官网等相关专业网站,采用主题词和自由词结合的方式检索,以“桡骨远端骨折”“指南”“专家共识”“骨科”等为关键词,检索时间从建库至2024年8月1日。使用临床指南研究与评估系统Ⅱ(AGREEⅡ)工具从6个领域对纳入的指南进行方法学质量评价。结果:共纳入10部指南,在范围和目的、参与人员、制定的严谨性、表达的清晰性、应用性和编辑独立性6个维度的标准化百分比分别为79.17%、64.45%、60.41%、64.17%、57.29%、71.29%。3篇指南的推荐级别为A级(推荐),5篇指南的推荐级别为B级(修改完善后推荐),2篇指南的推荐等级为C级(暂不推荐)。5项国外指南中,2项推荐等级为A级,3项为B级;国内5项指南中,2项西医指南等级分别为A级和B级,1项中西医结合指南推荐等级为B级,2项中医指南推荐指南均为C级。结论:国外桡骨远端骨折指南的方法学质量优于国内指南,而国内中西医结合指南的方法学质量优于中医指南。 展开更多
关键词 桡骨远端骨折 临床指南 专家共识 方法学 临床指南研究与评估系统Ⅱ 质量评价 方法学质量 系统评价
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面向混合整数线性规划问题的智能分支定界算法综述 认领 引用
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作者 张雪峰 彭潇 +2 位作者 陈良育 杨争峰 曾振柄 《运筹学学报（中英文）》 CSCD 北大核心 2026年第2期238-270,共33页
混合整数线性规划(mixed integer linear programming,MILP)问题遍布现实世界的各个领域。精确求解混合整数线性规划问题属于NP-hard问题,目前先进的规划问题求解器一般以分支定界法(branch and bound,B&B)作为核心框架。但分支定... 混合整数线性规划(mixed integer linear programming,MILP)问题遍布现实世界的各个领域。精确求解混合整数线性规划问题属于NP-hard问题,目前先进的规划问题求解器一般以分支定界法(branch and bound,B&B)作为核心框架。但分支定界法的固有性质导致其在执行过程中的一个错误决策可能会使分支定界树膨胀,降低搜索效率。如此复杂且数据丰富的环境使得利用机器学习技术改进分支定界算法成为可能。因此,将数据驱动的机器学习方法与分支定界算法相结合从而改进其决策过程受到越来越多的重视。本文首先介绍分支定界算法,并就其中影响性能的决策过程进行分析。之后,主要从基于行为克隆(behavioral cloning)的模仿已存在的专家策略的深度学习方法以及基于发现新策略思想的强化学习(reinforcement learning,RL)方法两方面着重综述了近年来关于将机器学习方法集成到分支定界算法中的研究工作。最后,我们讨论了未来关于结合机器学习与分支定界算法可能存在的方向以及挑战。 展开更多
关键词 混合整数线性规划 精确算法 分支定界 深度学习 强化学习
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颅脑超声与肌酸激酶同工酶联合检测在新生儿颅内出血诊断中的应用价值研究 认领 引用
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作者 彭潇 鹿皎 +2 位作者 赵进娥 王军 王兴田 《中国临床医学影像杂志》 CAS CSCD 北大核心 2026年第5期314-317,共4页
目的 :探讨颅脑超声(CUS)与肌酸激酶同工酶(CK-MB)指标联合检测在新生儿颅内出血(ICH)诊断中的应用价值。方法:回顾性纳入2020年1月—2024年12月我院新生儿科收治的经CT/MRI检查确诊为ICH的42例患儿作为观察组,另选同期41例临床排除ICH... 目的 :探讨颅脑超声(CUS)与肌酸激酶同工酶(CK-MB)指标联合检测在新生儿颅内出血(ICH)诊断中的应用价值。方法:回顾性纳入2020年1月—2024年12月我院新生儿科收治的经CT/MRI检查确诊为ICH的42例患儿作为观察组,另选同期41例临床排除ICH患儿作为对照组。两组患者均接受CUS、CK-MB检测。比较两组新生儿大脑中动脉参数、CK-MB;比较观察组CUS、CK-MB检测及联合检测对ICH患者的检出例数、检出率和诊断效能。结果:CUS诊断33例,漏诊9例,CKMB诊断31例,漏诊11例。与对照组患儿比较,观察组患儿大脑中动脉收缩期峰值流速(PSV)参数较低、阻力指数(RI)参数和CK-MB较高,差异均有统计学意义(P<0.05)。观察组CUS、CK-MB两者联合检测的检出率为85.71%,均高于CUS检出率(78.57%)、CK-MB检出率(73.81%),但无显著性差异(P<0.05)。与CUS、CK-MB单项诊断相比,联合检测对ICH的诊断价值较高,差异有统计学意义(P<0.05)。联合检测对ICH的曲线下面积最大,为0.937,灵敏度为0.857。结论:CUS与CK-MB联合检测在ICH诊断中的诊断效能显著优于单项检测,能够为早期诊断及干预提供依据。 展开更多
关键词 颅内出血 婴儿 新生 超声检查 多普勒 彩色
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高效液相色谱法测定含五味子化妆品中5种木脂素含量 认领 引用
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作者 刘丹 石文想 +1 位作者 彭潇 孙绪 《香料香精化妆品》 CAS 2026年第2期160-163,共4页
建立高效液相色谱(HPLC)法同时测定含五味子化妆品中5种木脂素(五味子醇甲、五味子醇乙、五味子酯甲、五味子酯乙和戈米辛N)的含量。样品经甲醇提取,采用Osaka Soda Capcell Pak MGⅡC18色谱柱,以0.1%(体积分数)磷酸水-乙腈为流动相... 建立高效液相色谱(HPLC)法同时测定含五味子化妆品中5种木脂素(五味子醇甲、五味子醇乙、五味子酯甲、五味子酯乙和戈米辛N)的含量。样品经甲醇提取,采用Osaka Soda Capcell Pak MGⅡC18色谱柱,以0.1%(体积分数)磷酸水-乙腈为流动相进行梯度洗脱。结果显示,5种木脂素类化合物在各自线性范围内线性关系良好,相关系数(R2)0.999。在4种不同基质样品中,5种木脂素类化合物的平均加标回收率为99.23%~109.97%,相对标准偏差均小于2.00%(n=6),检出限为0.10~0.20 mg/kg、定量限为0.33~0.67 mg/kg。经方法学验证该方法适用于含五味子化妆品中5种木脂素类化合物含量的同时测定。 展开更多
关键词 化妆品 高效液相色谱 五味子 木脂素 含量测定
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急性脑梗死患者血清CXCL11、GDF11水平与神经功能缺损程度及预后的关系 认领 引用
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作者 彭晓 田磊 +5 位作者 杨维娜 侯倩倩 郭静 武小蒙 熊文洁 王倩 《检验医学与临床》 CAS 2026年第2期265-270,共6页
目的探讨急性脑梗死(ACI)患者血清C-X-C基序趋化因子11(CXCL11)、生长分化因子11(GDF11)水平与神经功能缺损程度及预后的关系。方法选取2022年5月至2024年4月在该院接受治疗的175例ACI患者作为研究对象,根据美国国立卫生研究院卒中量表... 目的探讨急性脑梗死(ACI)患者血清C-X-C基序趋化因子11(CXCL11)、生长分化因子11(GDF11)水平与神经功能缺损程度及预后的关系。方法选取2022年5月至2024年4月在该院接受治疗的175例ACI患者作为研究对象,根据美国国立卫生研究院卒中量表评分结果,将其分为轻度缺损组(n=72)、中度缺损组(n=67)和重度缺损组(n=36)。患者出院后,随访3个月,采用改良RANKIN量表(mRS)评估患者神经功能恢复情况,并根据mRS评分结果将患者分为预后良好组和预后不良组。收集患者基线资料。采用酶联免疫吸附试验检测血清CXCL11、GDF11水平。采用Spearman相关分析ACI患者血清CXCL11、GDF11水平与神经功能缺损程度的相关性。采用多因素Logistic回归分析ACI患者预后不良的影响因素。绘制受试者工作特征(ROC)曲线分析血清CXCL11、GDF11对ACI患者预后不良的预测价值。结果与轻度缺损组相比,中度缺损组和重度缺损组血清CXCL11水平明显升高,血清GDF11水平明显降低,差异均有统计学意义(P<0.05);与中度缺损组相比,重度缺损组血清CXCL11水平明显升高,血清GDF11水平明显降低,差异均有统计学意义(P<0.05)。Spearman相关分析结果显示,ACI患者血清CXCL11水平与神经功能缺损程度呈正相关(r=0.406,P<0.05),血清GDF11水平与神经功能缺损程度呈负相关(r=—0.456,P<0.05)。mRS评分结果显示,预后良好组有124例,预后不良组有51例。预后不良组患者梗死体积、白细胞计数及血清CXCL11水平明显高于预后良好组,血清GDF11水平明显低于预后良好组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,梗死体积增大、白细胞计数及血清CXCL11水平升高均是ACI患者预后不良的危险因素(P<0.05),而血清GDF11水平升高是ACI患者预后不良的保护因素(P<0.05)。ROC曲线分析结果显示,血清CXCL11、GDF11联合预测ACI患者预后不良的曲线下面积大于各指标单独检测的AUC(P<0.05)。结论ACI患者血清CXCL11水平升高,血清GDF11水平降低,二者均与ACI患者神经功能缺损程度及预后相关,且二者联合预测ACI患者预后不良的价值更高。 展开更多
关键词 急性脑梗死 神经功能缺损程度 C-X-C基序趋化因子11 生长分化因子11 预后 相关性 预测价值
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Highly Efficient and Stable Capacitive Deionization Based on a Flower-Like Conjugated Polymer with Double Active-Sites 认领 引用 被引量：2
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作者 Zhiyun Zhuang Lei Sun +9 位作者 Yueheng Tao Jian Shao Jinggang Yang Peng Yu Huanxu Chen Jianhua Zhou Jing Xiao Kangyong Yin Minjie Shi Peng Xiao 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2025年第3期244-252,共9页
Hybrid capacitive deionization(HCDI)shows promise for desalinating brackish and saline water by utilizing the pseudocapacitive properties of faradaic electrodes.Organic materials,with their low environmental impact an... Hybrid capacitive deionization(HCDI)shows promise for desalinating brackish and saline water by utilizing the pseudocapacitive properties of faradaic electrodes.Organic materials,with their low environmental impact and adaptable structures,are attractive for this application.However,their scarcity of active sites and tendency to dissolve in water-based solutions remain significant challenges.Herein,we synthesized a polynaphthalenequinoneimine(PCON)polymer with stable long-range ordered framework and rough three-dimensional floral surface morphology,along with high-density active sites provided by C=O and C=N functional groups,enabling efficient redox reactions and achieving a high Na+capture capability.The synthesized PCON polymer showcases outstanding electroadsorption characteristics and notable structural robustness,attaining an impressive specific capacitance of 500.45 F g-1 at 1 A g-1 and maintaining 86.1%of its original capacitance following 5000 charge–discharge cycles.Benefiting from the superior pseudocapacitive properties of the PCON polymer,we have developed an HCDI system that not only exhibits exceptional salt removal capacity of 100.8 mg g-1 and a remarkable rapid average removal rate of 3.36 mg g-1 min-1 but also maintains 97%of its initial desalination capacity after 50 cycles,thereby distinguishing itself in the field of state-ofthe-art desalination technologies with its comprehensive performance that significantly surpasses reported organic capacitive deionization materials.Prospectively,the synthesis paradigm of the double active-sites PCON polymer may be extrapolated to other organic electrodes,heralding new avenues for the design of high-performance desalination systems. 展开更多
关键词 capacitive deionization electro-adsorption Na+removal organic compound pseudocapacitive electrode
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多灾耦合作用下雷达天线罩力学性能研究 认领 引用
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作者 彭晓 邹佳懿 +1 位作者 赵晨 李润鹏 《山西建筑》 2026年第11期7-12,共6页
为研究雷达天线罩在多灾耦合作用下的力学性能,文中基于有限元模拟软件,对采用柔性玻璃纤维复合材料蒙皮的某38 m直径单层球面网壳结构以及网架关键节点,在风、雪、自重、地震等荷载耦合作用下的承载力、稳定性和变形变化趋势进行分析... 为研究雷达天线罩在多灾耦合作用下的力学性能,文中基于有限元模拟软件,对采用柔性玻璃纤维复合材料蒙皮的某38 m直径单层球面网壳结构以及网架关键节点,在风、雪、自重、地震等荷载耦合作用下的承载力、稳定性和变形变化趋势进行分析。结果表明:在风、雪、自重、地震等荷载最不利组合工况作用下,柔性蒙皮-球面网壳结构容易出现局部屈曲失稳,但结构的整体刚度、强度和稳定性均满足规范要求;玻璃纤维复合材料蒙皮应力主要集中在各节点螺栓孔周围,法兰盘结构节点应力主要集中在钢杆件与节点焊接连接处,各材料应力均小于材料的许用应力,表明玻璃纤维复合材料蒙皮和法兰盘结构节点可以应用于多灾作用下的单层球面网壳结构。 展开更多
关键词 单层球面网壳 结构设计 柔性蒙皮 节点分析
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依达拉奉右莰醇联合重复经颅磁刺激治疗脑梗死后血管性痴呆临床研究 认领 引用
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作者 王倩 彭晓 宋彦丽 《中国药业》 CAS 2026年第9期113-116,共4页
目的探讨依达拉奉右莰醇联合重复经颅磁刺激(rTMS)治疗脑梗死后血管性痴呆的临床疗效。方法前瞻性选取医院2023年8月至2025年7月收治的脑梗死后血管性痴呆患者150例,按随机数字表法分为对照组和观察组,各75例。两组患者均予常规治疗及r... 目的探讨依达拉奉右莰醇联合重复经颅磁刺激(rTMS)治疗脑梗死后血管性痴呆的临床疗效。方法前瞻性选取医院2023年8月至2025年7月收治的脑梗死后血管性痴呆患者150例,按随机数字表法分为对照组和观察组,各75例。两组患者均予常规治疗及rTMS治疗,观察组患者加用依达拉奉右莰醇。两组患者均连续治疗3周。结果观察组患者总有效率为93.33%,显著高于对照组的80.00%(P0.05)。结论依达拉奉右莰醇联合rTMS治疗脑梗死后血管性痴呆的临床疗效较好,可改善患者的脑血流动力学指标,促进认知功能恢复,抑制炎性反应,且安全性良好。 展开更多
关键词 依达拉奉右莰醇 重复经颅磁刺激 脑梗死 血管性痴呆 临床疗效
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