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A Novel Fractional Plastic Damage Model for Quasi-brittle Materials 认领 引用 被引量：2
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作者 Peng-Fei Qu Qi-Zhi Zhu 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2021年第5期706-717,共12页
In this work,a novel constitutive model is developed within the framework of fractional plasticity to delineate the coupling between inelastic deformation and damage of quasi-brittle materials.Faced with the common ch... In this work,a novel constitutive model is developed within the framework of fractional plasticity to delineate the coupling between inelastic deformation and damage of quasi-brittle materials.Faced with the common challenge of determining plastic flow direction,we resort herein to the Riemann–Liouville definition of fractional derivatives,instead of introducing an additional plastic potential.The pre-peak hardening behavior is described using an exponential function,while the post-peak softening response is viewed as the consequence of material damage.For describing damage evolution,a damage criterion is constructed in terms of plastic volume dilation related to micro-crack growth.This is conducive to supply a new insight for describing the complex influence of the non-orthogonality of plastic flow on damage evolution.For numerical applications,a semi-implicit return mapping algorithm is proposed.The predictive performance of the model is evaluated by comparing numerical simulations with experimental data under various loading paths. 展开更多
关键词 Quasi-brittle materials Fractional plasticity Damage Dilatancy Numerical algorithm
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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy 认领 引用 被引量：2
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作者 Yu-Qin Wang Di Pan +7 位作者 Zhi-Yuan Yao Yu-Qi Li Peng-Fei Qu Run-Bang Wang Qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu 《World Journal of Gastroenterology》 SCIE CAS 2024年第37期4132-4148,共17页
BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent form.Despite the current availability of multiple immune or immune combination trea... BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent form.Despite the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely important.AIM To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic Liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent categories.METHODS Retrospective data were collected from 126 HCC patients treated with lenvatinib plus camrelizumab.Patients were divided into two groups based on BMI:The non-overweight group(BMI0.05).Subgroup analysis based on BMI showed that obese and overweight patients had better progression-free survival and OS than non-overweight patients,with obese patients showing the best outcomes.Multifactorial regression analysis identified BCLC grade,alpha-fetoprotein level,portal vein tumor thrombosis,and BMI as independent prognostic factors for OS.The column-line graph model highlighted the importance of BMI as a major predictor of patient prognosis,followed by alpha-fetoprotein level,BCLC classification,and portal vein tumor thrombosis.CONCLUSION BMI is a long-term predictor of the efficacy of lenvatinib plus camrelizumab,and obese/overweight patients have a better prognosis. 展开更多
关键词 Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety
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Complementary feeding patterns among ethnic groups in rural western China 认领 引用 被引量：2
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作者 Peng-fei QU Ya ZHANG +7 位作者 Jia-mei LI Ruo ZHANG Jiao-mei YANG Fang-liang LEI Shan-shan LI Dan-meng LIU Shao-nong DANG Hong YAN 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2018年第1期71-78,共8页
Objective： This study investigated complementary feeding practices among four ethnic groups（Han, Uygur, Tibetan, and Zhuang） based on a cross-sectional survey in rural western China. Methods： In 2005, a stratified... Objective： This study investigated complementary feeding practices among four ethnic groups（Han, Uygur, Tibetan, and Zhuang） based on a cross-sectional survey in rural western China. Methods： In 2005, a stratified multistage cluster random sampling method was used to recruit 9712 children（7411 Han, 1032 Uygur, 678 Tibetan, and 591 Zhuang） between 6 and 35 months of age and their mothers from 45 counties in 10 provinces（autonomous regions, municipalities） in western China. Results： The rates of early introduction（before 6 months） of complementary foods in four ethnic groups（Han, Uygur, Tibetan, and Zhuang） were 71.30%, 95.95%, 82.40%, and 72.30%, respectively. The Infant and Child Feeding Index（ICFI） for Uygur and Tibetan children was lower than that for Han children at all age groups. Uygur children were more likely to have unqualified ICFI compared with Han children in a multivariate logistic regression（odds ratio（OR）=5.138, 95% confidence interval（CI）： 4.340–6.084）. A higher level of maternal education, greater family wealth, and the availability of complementary feeding educational materials decreased the likelihood of an unqualified ICFI. The nutritional status of children（Han, Tibetan, and Zhuang） with qualified ICFI was better than that for children with unqualified ICFI. Conclusions： Appropriate interventions are required to improve complementary feeding practices in rural western China. 展开更多
关键词 Complementary feeding Infant and Child Feeding Index （ICFI） Ethnic group Westem China
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High-power and high optical conversion efficiency diode-end-pumped laser with multi-segmented Nd:YAG/Nd:YVO-4 认领 引用
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作者 Meng-Yao Wu Peng-Fei Qu +3 位作者 Shi-Yu Wang SEl Zhen Guo De-Fang Cai Bing-Bin Li 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第9期306-310,共5页
A novel flat-flat resonator consisting of two crystals（Nd：YAG ＋ Nd：YVO4） is established for power scaling in a diode-end-pumped solid-state laser. We systematically compare laser characteristics between multi-seg... A novel flat-flat resonator consisting of two crystals（Nd：YAG ＋ Nd：YVO4） is established for power scaling in a diode-end-pumped solid-state laser. We systematically compare laser characteristics between multi-segmented（Nd：YAG ＋ Nd：YVO4） and conventional composite（Nd：YAG ＋ Nd：YAG） crystals to demonstrate the feasibility of spectral line matching for output power scale-up in end-pumped lasers. A maximum continuous-wave output power of 79.2 W is reported at 1064 nm, with Mx2= 4.82, My2= 5.48, and a pumping power of 136 W in the multi-segmented crystals（Nd：YAG ＋ Nd：YVO4）. Compared to conventional composite crystals（Nd：YAG ＋ Nd：YAG）, the optical-optical conversion efficiency of multi-segmented crystals（Nd：YAG ＋ Nd：YVO4） from 808 nm to 1064 nm is enhanced from 30% to 58.8%,while the laser output sensitivity as affected by the diode-laser temperature is reduced from 55% to 9%. 展开更多
关键词 diode-pumped solid-state laser multi-segmented crystals（Nd：YAG ＋ Nd：YVO4） spectral line matching diode-laser temperature
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Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy 认领 引用 被引量：1
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作者 Di Pan Hao-Nan Liu +6 位作者 Peng-Fei Qu Xiao Ma Lu-Yao Ma Xiao-Xiao Chen Yu-Qin Wang Xiao-Bing Qin Zheng-Xiang Han 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第2期273-286,共14页
Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human health.Owing to challenges in early diagnosis,most patients lose the opportunity for radical treatment when diagnosed.N... Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human health.Owing to challenges in early diagnosis,most patients lose the opportunity for radical treatment when diagnosed.Nonetheless,recent advancements in cancer immunotherapy provide new directions for the treatment of HCC.For instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with HCC.However,tumor cells can evade the immune system through various mechanisms.With the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer vaccines.This review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC. 展开更多
关键词 Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions
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低层错能镍基单晶高温合金压缩行为和变形组织的温度相关性 认领 引用 被引量：11
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作者 杨文超 屈鹏飞 +6 位作者 刘晨 曹凯莉 秦嘉润 苏海军 张军 任翠东 刘林 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2023年第1期157-167,共11页
在室温至1000℃的范围内,研究温度对一种低层错能镍基单晶高温合金压缩行为和变形组织的影响。研究结果表明,压缩行为和变形组织均表现出温度相关性。室温下该合金具有较高屈服强度,600℃时屈服强度有所下降;随后,随着温度的升高,屈服... 在室温至1000℃的范围内,研究温度对一种低层错能镍基单晶高温合金压缩行为和变形组织的影响。研究结果表明,压缩行为和变形组织均表现出温度相关性。室温下该合金具有较高屈服强度,600℃时屈服强度有所下降;随后,随着温度的升高,屈服强度持续增加,并在800℃时达到最大值;在800℃以上时,屈服强度迅速降低。通过透射电子显微镜观察揭示合金变形机制。位错缠结和位错对塞积是室温下屈服强度较高的主要原因。在600℃时,变形机制从反相畴界切割向堆垛层错切割转变,这导致屈服强度略有下降。在800℃时,变形机制以堆垛层错切割为主,而Lomer-Cottrell锁和不同方向堆垛层错之间的反应导致最大的屈服强度。在900℃及以上时,虽然仍存在一些层错,但主要变形机制为位错绕过机制。最后,讨论变形机制和压缩行为的温度依赖性。 展开更多
关键词 镍基单晶高温合金 位错结构 堆垛层错 压缩行为
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